| class |
name |
apoptosis
|
NFkB
|
JNK/p38 |
Binding partner |
Structure |
3D |
KO |
gene |
locus |
upstream regulators |
expression
|
signals |
memo |
| MAP4K |
MAP4K1, HPK1(human,
mouse) |
enhance
|
activate
|
activate |
Crks,
Grb2,
BLNK,
SLP76,
HS1,
GRAP2,
EGFR |
kinase/CNH |
|
|
1 |
19q13.1-q13.4 |
IL5 |
APCs, B, T, NK
|
TCR/BCR,
Epo,
Syk |
to MEKK1, casp3 |
|
MAP4K2, RAB8IP, GCK (human,
mouse, rat,
fly,
C.e.) |
sensitize/inhibit
|
activate
|
activate |
MEKK1,
TRAF2,
Rab8 |
kinase/CNH |
|
|
1 |
11q13 |
Wnt3a |
B
|
|
|
|
MAP4K3/GLK/RAB8IPL1(human,
mouse) |
|
|
activate |
|
kinase/CNH |
|
|
1 |
1p34.1-p32 |
|
ubiquitous |
IL10/LPS |
|
|
MAP4K4, NIK, HGK(human,
mouse) |
|
|
activate |
NCK,
MEKK1,
GBP3,
RasGAP,
p65DOK,
b1
integrin, |
kinase/CNH |
|
|
1 |
2q11.2-q12 |
Rb2,
Fas,
camptothecin |
ubiquitous |
|
|
|
MAP4K5, KHS,
GCKR
(human,
mouse) |
|
(-)
|
activate |
Crks,
TRAF2 |
kinase/CNH |
|
|
1 |
14q11.2-q21 |
methamphetamine |
ubiquitous |
|
|
|
NRK(human
partial, mouse) |
|
|
|
|
kinase/CNH |
|
|
1,2 |
Xq22 |
|
ubiquitous |
|
|
|
MINK, misshapen (human
1, 2,
mouse 1,2) |
|
|
|
Dock |
kinase/cc/CNH |
|
|
1 |
17p13.2 |
|
ubiquitous |
|
|
|
DMPK (human) |
|
|
|
MKBP,
Raf1 |
|
|
|
|
19q13.3 |
|
heart
|
|
|
|
MRCKbeta, DMPK-like CDC42BPB (human) |
|
|
|
CDC42 |
kinase/cc/C1/PH/CNH/PHD |
|
|
|
14q32.3 |
|
ubiquitous (highest in brain)
|
|
|
|
CDC42BPA, PK428 (human) |
|
|
|
CDC42,
GM-CSF
Ra |
|
|
|
|
1q42.11 |
|
brain, spinal cord
|
|
|
|
MASK, MST4 (human) |
|
|
|
CDC25a,
Raf |
kinase/cc |
|
|
1 |
Xq25-26.3 |
estrogen
|
NK, B, T, APCs
|
|
|
|
Citron kinase, CRIK, STK21 (human) |
inhibit
|
|
|
Rho |
kinase/CNH |
|
1 |
|
12q24.1-q24.3 |
Ret
|
ubiquitous (highest in brain) |
|
|
|
MIG-15(C.e.) |
|
|
require |
|
kinase/CNH |
|
|
1 |
|
|
|
|
|
| Ste20 |
PAK1(human,
mouse,
rat),
frog,
dPAK1(fly),
C.e.,
Ste20(Sc,
Sp) |
protect
|
activate
|
activate/(-) |
Cdc42, Rac1, Nck,
Tak1,
PI3K,
Hgs,
PITSLRE |
PBD/kinase |
1 |
|
1 |
11q13-q14 |
TGFb |
ubiquitous |
CXCL1,
Fas,
casp3,
PDK1,
Rac,
Cdc42,
CDK5 |
p. Bad,
casp3 |
|
PAK2 (human,
rabbit,
rat) |
affect
morph.?
|
|
activate |
Cdc42, Rac1, Pixb |
PBD/kinase |
|
|
1 |
3q29 |
TGFb,
FSH,
Hp,
Fas,
camptothecin,
progesterone
|
ubiquitous |
|
casp |
|
PAK3 (human,
mouse,
rat) |
|
|
activate |
Cdc42, Rac1, Pixb,
Tax |
PBD/kinase |
|
|
1 |
Xq21.3-q24 |
AP-1 |
ubiquitous |
|
casp |
|
PAK4 (human) |
inhibit
|
|
weak act. |
Cdc42, LIMK1,
KGFR |
PBD/kinase |
|
1 |
1 |
19q13.13 |
|
ubiquitous |
|
|
|
PAK6, PAK5(human) |
inhibit
|
|
|
Cdc42,
Rac |
PBD/kinase |
|
1 |
1 |
15q14 |
RANTES
|
brain
|
|
|
|
PAK7, PAK5(human) |
|
|
activate |
|
PBD/kinase |
|
|
|
20p12 |
|
brain
|
|
|
|
SOK1,
YSK1,
STK25 (human,
mouse) |
|
|
(-) |
|
PBD/kinase |
|
|
1 |
2q37.3 |
SCF |
ubiquitous |
stress |
|
|
OSR1 (human) |
|
|
|
KCC3,
NKCC1,
NKCC2 |
kinase/RD |
|
|
1 |
3p22-p21.3 |
|
ubiquitous
|
|
|
|
SPAK, DCHT, STK39 (human) |
|
(-)
|
activate
|
KCC3,
NKCC1,
NKCC2,
PKCtheta |
TM?/kinase/RD |
|
|
1 |
2q31.1 |
androgen |
ubiquitous (highest in brain)
|
|
|
|
STK36 (human),
Fused, FU (Dm) |
|
|
|
|
kinase/?/HEAT |
|
|
|
2q35 |
|
ubiquitous |
GLI2 |
|
|
STK2, NRK2, NEK4 (human) |
|
|
|
|
kinase/PX |
|
|
|
3p21.1 |
HBV |
ubiquitous |
TTF1,
TNFa,
LPS,
Sm
|
|
|
STK3, MST2, Krs1(human) |
inhibit
|
|
(-) |
|
kinase |
|
|
|
8q22.2 |
IL1 |
ubiquitous |
stress, |
|
|
STK24, STK3, MST3(human) |
|
|
|
|
kinase |
|
|
1 |
13q31.2-q32.3 |
IL1,
RA |
ubiquitous |
|
|
|
STK4, MST1, Krs2(human),
Hippo (Dm) |
induce
|
|
|
DAP4,
MST1 |
kinase |
|
|
1 |
20q12-13.2 |
LPS |
hemato.
|
MT-21 |
casp,
Ub |
|
STK6, AIP (human) |
|
|
|
|
|
|
|
|
20q13.2-q13.3 |
LPS,
ALA,
NO
|
bone marrow, preB, endothelial,
testis
|
|
|
|
STK9, CDKL5 (human) |
|
|
|
|
|
|
|
|
Xp22 |
|
ubiquitous |
|
|
|
Aurora kinase A, STK15, ARK1, AURKA (human) |
|
|
|
|
kinase |
|
|
|
20q13 |
E2F1,
Rb2,
ER,
estrogen |
|
|
|
|
Aurora kinase B, STK12, STK5/mSTK1, ARK2, AIM1 (human,mouse) |
|
|
|
|
kinase |
|
|
|
17p13.1 |
FKHR,
ER,
estrogen |
preB
|
|
|
|
STK22B (human) |
|
|
|
|
kinase |
|
|
|
22q11.21 |
ARNT2
|
ubiquitous |
|
|
|
STK22C, STK22D (human) |
|
|
|
|
kinase |
|
|
|
1p35-p34 |
|
ubiquitous |
|
|
|
SSTK (human) |
|
|
|
|
kinase |
|
1
|
|
19p13.11 |
|
testis
|
|
|
|
STK18, SAK, PLK4 (human) |
|
|
|
|
kinase/RD |
|
|
|
4q27-q28 |
|
bone marrow, preB, endothelial |
|
|
|
SLK,
SMAK, STK2 (human,
mouse) |
promote
|
|
activate |
|
kinase/RD |
|
|
1 |
10q24.32 |
|
ubiquitous |
|
casp |
|
STK25, SOK1, YSK1(human) |
|
|
|
|
kinase/RD |
|
|
1 |
2q37.3 |
|
ubiquitous |
|
|
|
ILPIPA, CALS-21, PRO1038, ALS2CR2 (human) |
inhibit
|
|
enhance |
XIAP |
kinase |
|
|
|
2q33-q34 |
|
erythroid, loocyte
|
|
|
|
LYK5 (human) |
|
|
|
|
kinase |
|
|
|
17q24.2 |
|
ubiquitous |
|
|
|
STK10,
Plkk1,
LOK
(human,
mouse, frog) |
|
|
(-) |
Plk1 |
kinase/RD |
|
|
|
5q35.1 |
GR |
NK, B, T, APCs
|
|
polo-KK |
|
JIK,
KDS(human,
mouse) |
|
|
inhibit
|
|
kinase/RD |
|
|
|
12q |
|
NK, B, T, APCs |
EGF |
|
|
TAO1(human,
rat) |
|
|
activate
|
|
kinase/RD |
|
|
|
16 |
|
ubiquitous |
|
|
|
TAO2,
PSK (human,
rat) |
|
|
activate
|
MEK3,6 |
kinase/RD |
|
|
|
16p12.1 |
|
ubiquitous |
|
MEKK |
|
NEK1 (human) |
|
|
|
|
|
|
|
|
4q32.3 |
|
ubiquitous |
|
|
|
NEK2 (human) |
|
|
|
|
kinase/cc |
|
|
|
1q32.2-q41 |
AIRE
|
bone marrow, preB, endothelial,
testis
|
|
|
|
NEK3 (human) |
|
|
|
|
|
|
|
|
13q14.13 |
CSBG
|
ubiquitous |
|
|
|
NEK6 (human) |
inhibit?
|
induce
|
|
|
|
|
|
|
9q33.3-q34.11 |
|
ubiquitous |
|
|
|
NEK7 (human) |
|
|
|
|
|
|
|
|
1q31.3 |
|
ubiquitous (heighest in blood
cells)
|
|
|
|
NEK9, NERCC (human) |
|
|
|
|
|
|
|
|
14q24.2 |
|
ubiquitous (heighest in blood
cells) |
|
|
|
NEK11 (human) |
|
|
|
|
|
|
|
|
3q22.1 |
|
ubiquitous |
|
|
casein kinase
|
CK-I alpha, CSNK1A1 (human)
|
inhibit
|
|
|
|
|
|
|
|
5q32
|
|
ubiquitous (highest in
epithelial)
|
|
|
|
CSNK1A1L (human)
|
|
|
|
|
|
|
|
|
13q13.2
|
|
|
|
|
|
CK-I gamma1, CSNK1G1 (human)
|
|
|
|
|
|
|
|
|
15q22.1-q22.31
|
|
ubiquitous |
|
|
|
CK-I gamma2, CSNK1G2 (human)
|
|
|
|
|
|
|
|
|
19p13.3
|
|
ubiquitous (heighest in blood
cells) |
|
|
|
CK-I gamma3, CSNK1G3 (human)
|
|
|
|
|
|
|
|
|
5q23
|
|
B, NK, epithelial, APCs
|
|
|
|
CK-I delta, CSNK1D (human)
|
|
|
|
|
|
|
|
|
17q25
|
|
B, NK, epithelial, APCs |
|
|
|
CK-I epsilon, CSNK1E (human)
|
|
|
|
|
|
|
|
|
22q13.1
|
|
ubiquitous |
|
|
|
LOC149420 (human)
|
|
|
|
|
|
|
|
|
1p35.3
|
|
|
|
|
|
VRK1 (human)
|
|
|
|
|
|
|
|
|
14q32
|
estrogen |
bone marrow, preB
|
|
|
|
VRK2 (human)
|
|
|
|
|
|
|
|
|
2p16-p15
|
|
bone marrow, preB, endothelial |
|
|
|
VRK3 (human)
|
|
|
|
|
|
|
|
|
19q13
|
|
testis, B, T
|
|
|
|
TTBK2 (human)
|
|
|
|
|
|
|
|
|
15q14
|
|
ubiquitous |
|
|