Transcription Factors
 

• NF-kB/I-kB/NF-AT

target element: GGGRNYYYCC
 

On-line Review

Review issue of NF-kB in Oncogene (1999)
NF-kB activation by Ghosh S, May MJ, Kopp EB (Annu Rev Immunol 1998), Baeuerle & Baltimore (Cell 1996), Richmond (Nat Rev Immunol 2002), Li & Verma (Nat Rev Immunol 2002)
proteasome by DeMartino GN, Slaughter CA (J. Biol. Chem. 1999)
PPARg by Willson et al. (Annu Rev Biochem 2001)
Transcriptional regulation during B cell development by Henderson & Calame (Annu Rev Immunol 1998)
Transriptional Coactivator by Tjian et al. (Annu. Rev. Biochem. 2001)

Rel/NF-kB Transcription Factor Web Site by Gilmore T.D. (Boston Univ)

Other Transcriptional Apoptosis Regulators
(See NFkB and Apoptosis Regulators, Kinases, too)
 
 

Group	Name	Element	KO	gene	locus	Apoptosis	Binding Partners	Structure	3D	Upstream regulators	memo
Ces	ces-1(C.elegans, C.b.)		1	1		inhibit		ZnF(Snail)
	ces-2(C.elegans)		1	1		induce		bZIP(PAR)
	ces-3(C.elegans)		1
Zn	SLUG(human, mouse), SNAI2,  SNAIL(D.m.)			1	8q11	inhibit		ZnF		PAX3-FKHR, MyoD, BMP2, HHV8	epithelial, adipocyte etc
	SNAI1 (human)				20q13.1					AdV
	Requiem, REQ (human, mouse), d4			1	11q13	inhibit		ZnF		D3
	RYBP, DEDAF, YY1AF2, YAF2 (human, mouse)			1	3		Casp8, Casp10, FADD, E2Fs, YY1	RING		Ma, ribavirin
	zf3, ZNF319 (human, mouse)				16q13	induce		ZnFx15
	PAG-3 (C.e.),  Gfi1 (human, rat)	IP	L	1	1p22	inhibit		SNAG/ZnFx7		BRN3C
	Egr1, Krox24, Zif268 (human, mouse)		L	1	5q31.1	mediate/inhibit	RelA		L	CREB, AP1, WT1, Egr1, ARNT2,  FKHR, Akt, PKCb, hypoxia, irrad., BRCA1, Ct, Ec, Ld, Sa, St, Tg, RSV, TNFa, TRAIL, RANKL, LPS, IFNg, IL5, CXCL9, IL1, GM-CSF, GnRH, VEGF, HPV11, FVIIa, IgM, TCR/CD3,  Notch, endostatin, fumagillin, insulin, IGF1, UV, ER stress, NO, O stress, GH, AgII, ET-1, PGE2, PMA, CsA, ethanol, heat shock, hypoxia, ER, PDX1, BMP2, Blimp1, OX-CA, KCl	targets
	Egr2, KROX20 (human)		1	1	10q21.1-q22.1	induce		ZnF		NF-AT, IL5, Fas, TCR/CD3, GnRH, VEGF, insulin, Lm, Tg, PTEN, estrogen, Rac2, D3
	ZNF365 (human)				10q21.2					TNFa	brain
	Egr3 (human)		L	1	8p23-p21	enhance		ZnF		NF-AT, c-Myc, IL5, IL8, VEGF,  Thrombin, estrogen, HHV8	brain
	Egr4, NGFI-C (human)	GSG	1		2p13					NGF, CREB
	Sp1 ( human)	cast			12q13.1	regulate			L		casp
	Sp3 (human)									phenytoin
	FKLF2, RFLAT1, KLF13 (human)				15q12		CBP/p300, PCAF				Erthroid, NK, APCs, B, T,
	TIEG (human)				8q22.2	induce		ZnFx3		TGFb, GR, TNFa, Wnt3a, HHT
	WT1 (human)		L		11p13	inhibit/induce	Ciao1			HOX11, c-Myc, PEA3, AP1, HNF4a, LIF, HBx, Vasopressin, RA	targets
	Zac1, Zac, Lot1, PLAGL1 (human)				6q24-q25	induce		ZnFx5
	Ikaros, IK1, Lyf1, ZNFN1A1 (human)		1		7p13-p11.1	regulate		ZnFx6		Tprim, LPS, VDR, IL5	hemato.
	H-plk (human)				7q11.21			ZnFx10		HCV core
	ZNF92, TF12, HPF12 (human)				7q11.21					CSBG	hemato.
	ZNF148, ZBP89 (human)				3q21	induce				FSH	hemato.
	ZNF24, KROX17 (human)				18q12					Ct	lymphocytes
	ZNF35, HF.10 (human)				3p22-p21					GR, insulin, IGF-II, UVB
	ZNF36 (human)				7q21.3-q22.1					RANKL, IL2, estrogen, GR, CREB, IGFBP2, HHV8
	ERF1,  ZFP36L1, BRF1, cMG1, ERF-1, Berg36, TIS11B, RNF162B (human)				14q22-q24		Sim1			PMA, EGF, IL4, ARNT2
	ZNF76 (human)				6p21.3-p21.2			ZnFx7			Sumo
	ZNF165, LD65 (human)				6p21.3			ZnFx5		IL8	testis
	WIZ (human)				19p13.1			ZnFx11		LPS
	LKLF, KLF2 (human)				19p13.1					TRAF2, PDGF	B, T, NK, APCs
	ZK1, ZNF443 (human)				19p13.2	enhance					preB
	ZNF43, HTF6 (human)				19p13.1-p12					AmB
	ZNF85 (human)				19p13.1-p12
	ZNF160, F11, HZF5, KR18, HKr18 (human)				19q13.3-q13.4			KRAB/ZnFx20		MeDNA
	ZNF91, HPF7, HTF10 (human)				19p13.1-p12			KRAB/ZnFx32		Ma, RA, GM-CSF, IGFBP2	brain, hemato.
	ZNF93, TF34, HPF34, HTF34 (human)				19p13.1-p12					ARNT2
	ZNF146, OZF (human)				19q13.1					c-Myc, progesterone	hemato.
	EKLF, KLF1 (human)				19p13.13-p13.12					Subst.P, LPS, GATA1, IL5	erythroid, endothelial
	ZNF382 (human)				19q13.13					Cdx2
	MZF1, ZNF42 (human)				19q13.2-q13.4					RA, EV71
	ZNF124, ZK7 (human)				1q44	inhibit				VEGF	erythroid
	ZNF125, HZF3 (human)				11q23.1-q23.2					FSH, b-catenin
	ZNF128 (human)				11q23.1-q23.2		TIF1beta
	PLZF, ZNF145 (human)		L		11q23.1	inhibit					lung, targets
	ZNF131 (human)				5p12-p11			ZnFx6		TNFa, Ct	hemato.
	ZNF132 (human)				19q13.4					IGFBP2
	ZNF133 (human)				20p11.23-20p11.22					HHV8
	ZNF134 (human)				19q13.4					IGFBP2	lymphocytes
	ZNF137 (human)				19q13.4					estrogen
	ZNF350, ZFQR, ZBRK1 (human)				19q13.41		BRCA1			DNA-damaging reagents
	ZNF143, SBF (human)	SPH			11p15.4	regulate?
	ZNF177 (human)				19p13.2					endostatin, fumagillin
	ZNF207 (human)				17q11.2			ZnFx2		SCF
	ZNF208 (human)				19p12
	ZNF408 (human)				18q23						bm
	KLF5, BTEB2 (human)		1		13q21.33		RAR			FKHR	epithelial
	KLF7, UKLF (human)				2q32					RANTES
	KLF4 (human)		L		9q31					endostatin, GnRH, estrogen	APCs, skin barrier
	BTEB, BTEB1, KLF9 (human)	GC box			9q13					Stat4b, insulin, IGF-II, PDGF, endostatin
	ZNF216 (human)				9q13-q21		ZNF216, IKKg, RIP, TRAF6	ZnF(A20)/ZnF(AN1)		LPS, IL10, TRRAP, PDGF	APCs, inhibit NF-kB
	ZNF217, ZABC1 (human)				20q13.2					estrogen	hemato.
	ZNF83, HPF1 (human)				19q13.3						lymphocytes
	ZNF257 (human)				19q13
	ZNF215 (human)				11p15.4			LER/KRAB/ZnFx4		TNFa
	ZNF274, ZFP2 (human), NRIF1(mouse)		1		19qter	(induce)	NGFR(p75NTR)	KRAB/LER/KRAB/ZnFx5		TCR	lymphocytes
	ZNF33A (human)				10p11.2			KRAB/ZnFx16		estrogen
	MOK2, ZNF239 (human)				10q11.22-q11.23		DNA, RNA			IGFBP2
	CIZ, NMP4, ZNF384 (human)	cast			12p12		CAS,				Bmp/Smad
	GLI1 (human)				12q13.2-q13.3					Brn3b, ARNT2
	ZNF205, ZNF210 (human)				16p13.3					IGFBP2
	ZF5, ZFP161 (human)	GSGCGCGR			18pter-p11.2		ZF5	BTB/ZFx5		D3
	ZNF238 (human)				1q44-qter					HHV8	cerebellum
	ZIC2, HPE5 (human)		L		13q32						cerebellum
	ZIC5, Opr (human)				13q32.3
	ZIC3, HTX1 (human), odd-paired (Dm)		hlx		Xq26.2						cerebellum
	ZNF288, HOF, DPZF (human)				3q13.2			BTB/ZFx5		HOX11
	SZF1-1, SZF1 (human)				3p21					AdV
	ZIC1 (human)		L		3q24			ZFx5		Bmp2	cerebellum
	ZIC4 (human)				3q24						cerebellum
	Evi1 (human)				3q24-q28			ZFx11		HCV core	B, T
	Bcl6, LAZ3, ZNF51 (human)	cast	L		3q27		N-CoR, SMRT, p300, HDAC1	BTB/ZFx6		HHV8, TNFa, FKHR, TIMP1	myeloid
	WIG1, PAG608 (human)				3q26.3-q27	mediate		ZnF(U1)x3		p53, BRCA1, LPS
	HIVEP1, PRDII-BF1, ZNF40, HIV-EP1, MBP-1 (human)				6p24-p22.3	induce		ZFx2/ZF/ZFx2		TNFa, LPS
	ZNF318 (human)				6pter-p12.1					TNFa	hemato.
	HIVEP3 (human), schnurri (Dm)				1p34	regulate
	Fliz1, LOC84524 (human)				2q12.3	induce
	Rp8, PDCD2 (human, mouse, rat)				6q27		N-CoR, Sin3A	ZnF(MYND)		Bcl6, Irradiation, RA, Dex.	hemato.
	ZPR9 (human)				5p15.1	induce	B-Myb
	Krox1, ZNF10 (human)				12q24.33		TIF1beta
	KRAZ2, ZFP68 (mouse)						TIF1beta				repressor
	Mzf22, ZFP87 (mouse)						TIF1beta
	KLF3 (human)							ZFx3		TCR, DEX	erthroid
	Bcl11a (human)		1	1	2p15			ZFx6			B, DC
	Bcl11b (human)		1	1	14q32.31			ZFx6			ab T cells
	FLJ14299 (human)				8p11.23			ZF		AdV
	MAX, ZF87, PUR1, SAF-1 (human)				16p11.2			ZFx6
	ZNF267, HZF2 (human)				16p11.2					AP1, TNFa	preB
	ZNF483, HIT-10 (human)				9q32					Cdx2
	AIRE (human)				21q22.3
RING	For ZNF144, 147, 313, 173, 179, 364, see RING proteins
GATA(Zn)	GATA1 (human)	GATA	L	1	Xp11.23	inhibit			list	Ets1,Ets2, Fli1, Tprim, SCF, Notch	erythroid, endothelial, targets, casp
	GATA2 (human)	GATA2	L		3q21		PIASy			GATA1, GM-CSF, Egr1, ARNT2, IL3, staurosporine	haematopoietic, SUMO
	GATA3 (human)	GATA3	L		10p15	promote				BCL6, Brn3a, Tprim, IL4, IL27, TGFb, Fliz1, ribavirin	T, NK, placenta
	GATA4 (human)		L		8p23.1-p22	inhibit				PMSG, estrogen, FSH , IL18, Akt	heart (endoderm)
	GATA5 (human)		1		20q13.33						genitourinary
	GATA6 (human)		1		18q11.1-q11.2			TTF1		PMSG, estrogen	adrenal,  heart (endoderm)
	TRPS1 (human)		1		8q24.12
C5HC2	Jumonji, JMJ (human)				6p24-p23					LPS
DHHC	ZDHHC8, ZNF378 (human)				22q11.21			TM/DHHC/TM		TNFa, NF-kB
	ZDHHC14 (human)				6q25.3			TM/DHHC/TM		AIRE
AREB6	AREB6, TCF8 (human)				10p11.2					Egr1, VEGF, Thrombin

Group	Name	Element	KO	gene	locus	Apoptosis	Binding Partners	Structure	3D	Upstream regulators	memo
NR (ZnF+Ligand BD)	RORalpha, ROR1 (human)				15q21-q22					Stat4a, HOX11	T, NK
	RORbeta, ROR2 (human)				9q22
	RORgamma, ROR3, RORC (human)		1	1	1q21	inhibit		NR			liver, LTi
	TR3, HMR, NGFI-B, GFRP1, Nur77, NP10, NR4a1 (human)	AAAAGGTCA		1	12q13	induce/inhibit	Bcl2	NR		Akt, PPARg1, LPS, Lm, BRCA1,  TCR, Nef, SDF1, KiSS1, GnRH, CRF, PTH, endostatin, estrogen, DEX, RARa, CREB, Cabin1, MEF2, HDAC7, hypoxia, camptothecin, AdV, MEKK1	adrenal cortex, targets
	Nurr1, NOT, RNR1, HZF-3, TINUR, NR4A2 (human)		1		2q22-q23					TCR, CRF, AgII
	PPAR alpha, PPARA (human)		L		22q13.31					AP1	targets
	PPAR gamma, PPARG (human)		L		3p25	promote	15dPGJ(2)	NR		BMPs, leptin, D3, Egr1, IL13, ALA	targets
	PPAR delta, PPARD (human)		L		6p21.2-p21.1	inhibit?	RA			TNFa, 15-LOX-1
	CSMF, Nor-1, MINOR, NR4A3 (human)				9q22	mediate		NR		PTH, Ask1, CREB , HOX11, IL1, IL8, Lm,  MDP,  LPS,  PMA	adrenal cortex
	LXRa, NR1H3 (human)		L		11p11.2		RXRa, GW3965			Mt	adipocyte, liver, 9cRA
	RXRa (human)		1		9q34.3	induce	cRA, RNF8		L	estrogen	erythroid
	RXRb (human)		1		6p21.3					RA, Subst.P, b-glucan, Hi
	RARa (human)				17q12	induce	SMRT, BAG1			IFNa,  IL5, c-Myc, WT1, palmitate, UVB	(myeloid)
	RARb (human)		1		3p24	promote				c-Myc, Epo, RA, PPARg	targets
	RARg (human)				12q13	induce				UVB, RA, insulin, Cp, TIMP1
	T3Ra, THRa, EAR7,erbAa (human)				17q11.2	induce/inhibit?	T3, N-CoR, SMRT	NR		PTH, D3, Nur77
	T3Rb, THRb, ErbA2, ErbAb (human)		L		3p24.3		SMRT	NR		AgII, Brn3b
	ERalpha, ESR1 (human)		L		6q25.1		SMAD4	NR		VEGF, Subst.P,LPS	uterus, estrogen targets
	ERbeta, ESR2 (human)		L		14q	mediate		NR
	AR (human)		L		Xq11.2-q12		Androgen, SMRT			LPS
	VDR (human)		L		12q12-q14	induce/inhibit	12q12-q14			WT1, D3, TNFa	targets
	GR, GCCR, NR3C1 (human)		1		5q31	mediate	CBP, glucocorticoid, DAP3			A2aR, Notch, HHV8, UVA	targets
	COUP-TFI, EAR3, ERBAL3, NR2F1 (human)		1		5q14		N-CoR, SMRT			IL1	brain
	EAR2, ERBAL2, NR2F6 (human)	TGACCT			19p13.1					Ye
	ELP, SF1, FTZ1, SF-1, AD4BP, FTZF1, NR5A1 (human), fushi tarazu (Dm)		L		9q33					ARNT2
	HNF4a, TCF14 (human)		1		20q12-q13.1			NR		palmitate
	HNF4g (human)				8q13.3-q21.11			NR			salibary gloand
	PXR, SXR, PAR1, NR1I2 (human)				3q12-q13.3					endostatin	liver, targets

 

Group	Name	Element	KO	gene	locus	Apoptosis	Binding Partners	Structure	3D	Upstream regulators	memo
p53	p53(list)	P box, cast	L	1	17p13.1	induce	DNA, GR, Rb, mdm2, Pirh2, LKB1, TFIIH, ERCC2, ERCC3, p62, p36, PIASy, Sin3a, SMN, BLM, securin, nucleolin, HIFa, ICP0, IkBa, SMAD2, Bcl-xL	AD/DB/Oligo/RD	list	c-fos, c-jun, ATF3, NF-kB, Myc,Max, Stat4, Hey1, Hes1, TFAP4, Osr1, NR2F2, SFRS10, Bcl6, WIG1, HIVEP1, IFNa, IFNb, gastrin, CD3, LPS, sBLP, MeDNA, dsRNA, Brn-3a/(-), HBx, EGR1, E2F1, c-Maf, p53, IRF9, SST, NO, TCDD, Mdm2, GADD45a, Chk2, FRAP, ER stress, GSK3b, HIPK2, Pin1, SIR2, NQO1, PLD,  IGF-I, HAUSP, UDCA	targets, JNK
	p73alpha(human),KET(rat)		L	1	1p36	promote(full) inhibit(dN)	DNA, mdm2, PMS2, c-Myc	AD/DB/Oligo	1	p53, p73, E2F1, PKCd, DNA damage, CDC2, CHK1, KCl	targets, E2F-1
	p63(human [ta alpha, ta beta, ta gamma , da alpha, da beta, da gamma], mouse[da alpha, da beta, da gamma, ta* alpha, ta* beta, ta* gamma])		L	1	3q27-q29	promote	DNA, SSRP1	AD/DB/Oligo		mdm2, UVB
	p53/CG10873(D.m.), CEP-1(C.e.)		L	L		mediate	DNA	AD/DB/Oligo		Chk2
	Rb (human)		L		13q14.1-q14.2	inhibit	p53, Cdk9, CMV pp71, DNMT1		L	LPS, Mt, CD40, GATA1, E2F1, p53, CREB, CBP, MyoD, IFNg, IL1a, SST, FSH, RA, NO	casp
	p107 (human)		L		20q11.2		E2Fs, CMV pp71			RA
	p130, Rb2, RBL2 (human)		L		16q12.2	(inhibit)	E2Fs, CMV pp71			TCR, IL1, CD40, BCR, PI3K, Egr1, ARNT2	targets, Ub
p53BP2	53BP2, ASPP2 (human), CG18375(Dm), F46F3.4(Ce)				1q42.1	enhance	p53, NF-kB, Bcl2, YAP, PP1	(RA)/coiled-coil/?/Ank x2/SH3		E2F1,UV	activates NF-kB
	ASPP1, PP1R13B(human)					enhance	p53	RA/coiled-coil/?/Ank x2/SH3
	RAI, iASPP (human)					inhibit	RelA	?/Ank x2/SH3
E2F1	E2F1 (human, mouse, chicken, Ce, Dm, At)	E2F, cast	L		20q11.2	mediate	Rb, DP1, DP2, TRRAP, cyclins, MAGEs, DNMT1, BECA1, TopBP1		L	CDK2, DNA damage, c-Myc, TR3, Hoxd10, IL5, IFNa, IFNb, Rbs, GABPgamma1, flavopiridol, AgII, RARb, RA, UDCA, estrogen, EV71, TIMP1, KCl	targets
	E2F2(human, mouse)		L		1p36	mediate/(-)	Rb		1	MyoD, GR, TGFb
	E2F3(human, mouse)		L		6p22	mediate/(-)	Rb			PMA, AgII, UVA, UVB, VDR, Cdx2
	E2F4(human, mouse)	cast	L		16q22.1	(-)	DP1, p130, p107			CD3/CD28, RANKL
	E2F5 (human, mouse)		1		8p22		p130, p107			RA, UVB, LPS, Sm
	E2F6(human, mouse)				22q11		RYBP
	E2F7 (human, mouse)
	FLJ23311  (human)				11p15.1
	DP1 (human, mouse)	cast			13q34		E2Fs			LPS, S.t., c-Myc,  C/EBPb, IFNg, FSH, heat shock, RA, DIM, I3C, ribavirin, IL5, estrogen, TIMP1
	DP2(human)	cast			3q23					IL15, TCR/CD3

Group	Name	Element	KO	gene	locus	Apoptosis	Binding Partners	Structure	3D	Upstream regulators	memo
HMG	(TCF1), TCF7 (human)		1		5q31.1			HMG		Wnt-1,AIRE, IL12, AP1, PMA, estrogen	Wnt
	TCF3 (human)		1		2		b-catenin	HMG			Wnt, hemato.
	TCF4, TCF7L2 (human)		L		10q25.3		b-catenin, PIASy	HMG		AP1, TIMP1	Wnt
	LEF1 (human)		L		4q23-q25	(inhibit)	b-catenin, PIASy	HMG		TCR, Notch	Wnt, T, SUMO
	TCF1/HNF1/LFB1/MODY3(human)				12q24.2			HMG			Wnt
	HBP1 (human)				7q22-q31			HMG		p38
	SOX2 (human)		L		3q26.3-q27					IGF1, AIRE	brain
	SOX3 (human)		1		Xq26-q27
	SOX4 (human)				6p22.3		syntenin			TNFa,, estrogen, FceRI	DC, bm
	SOX9, CMD1, CMPD1 (human)		1		17q24.3-q25.1	inhibit				TNFa,
	SOX10,DOM, WS4 (human)		1		22q13.1					Cdx2, ARNT2	brain
	SOX11 (human)				2p25					Subst.P, LPS	fetal brain
	SOX15 (human)		1		17p13						bladder
	HMG-I (human)									IFNg, TNFa, IGF1, LMP1, ALK1, irrad, DEX, HIV Vpr, estrogen
HIF	HIF1alpha (human)		L		14q21-q24	mediate	ARNT(HIFb), VHL, p53,	HLH/PASx2/PAC	L	AP1, Egl9, FOXO4, c-Myc, TNFa, IFNa, LPS, Ma	epithelium
	HIF1beta, ARNT  (human)				1q21
PAS	SRC1, NCoA1 (human)	inhibit	L		2p23		PR, ErbA2, JAB1, CIITA	HLH/PAS			NK
	TIF2, GRIP1, NCoA2 (human)	inhibit	L		8q13.2		p300, GR, TR, D3R, RARa, RXRa	HLH/PAS/PAC
	TRAM1, NCoA3, RAC3, ACTR, SRC3, AIB1, pCIP, CTG26, CAGH16, TNRC14, TNRC16 (human)				20q12			HLH/PAS		STAT6	hemato.
	NPAS2 (human)		L		2q11.2			HLH/PAS
TCF	TCF3, ITF1, E12, E47, E2A (human)				19p13.3			HLH		ARNT2	B, erhthroid
	TCF4, ITF2(human)				18q21.1	enhance		HLH			DC
	TCF12/HTF4(human)				15q21			HLH		c-Myc	hemato.
	bHLH-EC2, Meso1, TCF15 (human)				20p13					estrogen	hemato.
	TCF21 (human)		L		6pter-qter						lung
HES5	HES5 (human, mouse)				1			HLH		CREB	brain
IPT	EBF, OLF1, COE1 (human)		1		5q34			IPT/HLH		E12, CD40, Brn3b
	EBF2 (human)				8p21.2			IPT/HLH
	EBF3 (human)				10q26.3			IPT/HLH			brain
	EBF4  (human)				20p13			IPT/HLH
bHLHZip	c-Myc(human)	E box		1	8q24.12-q24.13	induce	Max, p73, p107, TRRAP, Tiam1, MM-1	AD/bHLHZip	1	IL1, IFNg, TNFa, RANKL, CD40, BAFF, TACI, TCR, CD3/28, PMA, LPS, Hp, Ma, Tg, MVA, HBx, TGFb, M-CSF, CD30, Wnt-3A, FSH, glucose, ET-1, ER stress, UVA, UVB, C/EBPa, GATA1, Pitx2, c-Myc, WT1, NF-kB, AP1, Smad3, E2F4, LEF1, ER, ARF, FVIIa, CARP1, g-irrad,Epo, TSH, MKK7, MEKK1, CsA/FK506, sIL6R, NO, ER, estrogen, RA, BRCA1, IL15, CD9, ALK1, Bcl6, AmB, cantharidin, HHT, PAK2	targets, Ub, calpain
	N-Myc (human)	E box	1	1	2p24.1	inhibit	Max, NMI	bHLHZip		IL1b, TRAIL, LPS, IKKg, S.t., LPS, Mad1, Pax5, WT1, E2F, RA,	targets, Ub
	L-Myc, MYCL1 (human)			1	1p34.3	inhibit	Max	bHLHZip		NF-kB, c-Myc, LPS, IL10, RA, IKKs
	L-Myc2, MYCL2 (human)				Xq22-q23					ALK1
	Max (human)		1	1	14q23	promote	Myc, Mxi, MNT, Mad, MLX	bHLHZip	L	CGRP, D3, adrenomedullin	hemato.
	MLX, TCFL4 (human)			1	17q21		Max	bHLHZip
	MNT, ROX(human)		1	1	17p13.3		Max	bHLHZip
	Mad (human)		1	1	2p13	promote	Max, Sin3a	bHLHZip		LPS, (p38), GATA1, estrogen, Egr1, IL12	myeloid, targets
	Mad3, MXD3 (human, mouse)		1		5q35.3	(inhibit)	Max	bHLHZip			erythroid, targets
	Mad4, MXD4 (human)				4p16.3					GR, OX40
	Mxi1 (human)		1	1	10q25		Max	bHLHZip		hypoxia, LPS	erythroid
	WBSCR14 (human)				7q11.23
	USF1 (human)				1q22-q23
	USF2 (human)		L		19q13					SCF, ErbB2, IL5
	TFE3 (human)		1		Xp11.22					IFNa
	TFEC (human)				7q21.2-q21.3						myeloid, APCs
	MGC2383 (human)				5q35.3						erythroid
	Dermo1 (human)				2q37.3
	MyoD, Myf3 (human)		L		11p15.4					EV71	NK, (muscle)
	myogenin, MYF4, MYOG (human)				1q31-q41					IGF1/Akt
	Myf5 (human)		L		12q21					estrogen, BMP2	(muscle)
	MondoA, MIR (human)				12q21.31						hemato.
	SREBP1, SREBF1 (human)			1	17p11.2		Max, DNA	AD/bHLHZip/TMx2			casp, targets
	SREBP2, SREBF2 (human)				22q13						targets
	DEC1, BHLHB2, CR8 (human)				3p26	inhibit		bHLH		IL2, IL4, VEGF, TGFb, Thrombin, Sa
	neurogenin 3, NEUROG3 (human)				10q21.3
	ASCL3 (human)				11p15.3
	ARNTL (human)				11p15
	Math1(human), atonal (Dm)				4q22	(inhibit)		bHLH			large intestine, hair cells in the mouse inner ear
	Atoh2, NEX1M, Math2, NEUROD6 (human)				7p15.3					CREB	brain
	MITF (human)		WS2, L		3p14.1-p12.3	inhibit/promote	UBC9, PIASy	bHLHZip			uterus, targets
	MyoR, ABF1, musculin , MSC (human)		1		8q21					Brn3a	preB
	HAND1 (human)		L		5q33						embryonic
	HAND2, dHAND, Thing2 (human)		1		4q33						subthalamic nucleus
	neuroD1, BETA2, BHF-1, NIDDM (human)		1		2q32						cerebellum
	neuroD2 (human)				17p13.1						brain
	neuroD6 (human)				7p15.1						brain
	neurogenin 1, NEUROG1, AKA, ngn1, Math4C (human)		L		5q23-q31
	neurogenin 2, Atoh4, ngn-2, Math4A, NEUROG2 (human)				4q25						preB
	neurogenin 3, ngn3, Atoh5, Math4B, NEUROG3 (human)				10q21.3
	Math1, ATH1, HATH1,  ATOH1 (human)		L		4q22
	PTF1A, PTF1-p48 (human)				10p12.31						pancreas
	ATOH7 (human)				10q22.1
	ATOH8, HATH6 (human)				2p11.2						liver, lung, thyroid
	OLIG1 (human)		L		21q22.11						brain, spinal cord
	OLIG2 (human)		1		21q22.11						brain, spinal cord
	OLIG3, Bhlhb7 (human)				6q23.2
	TAL1, SCL, TCL5 (human)		1		9q32	inhibit					bone marrow, casp
	LYL1 (human)				19p13.2-p13.1						APC, B, bone marrow
	NHLH1, HEN1, NSCL, NSCL1 (human)		1		1q22						brain, spinal cord
	NHLH2,NSCL2, HEN2 (human)		1		1p12-p11
	Beta3, CAGL85, TNRC20, BHLHB5 (human)				8q13
	FERD3L, NATO3, N-Twist (human)				7p21.1
	MIST1 (human)		1		7q22.1						prostate, salivary gland, thyroid
	twist-1 (human, mouse, zebrafish)		1		7p21.2						placenta, uterus
	twist-2, DERMO1 (human)		1		2q37.3					NF-kB, TNF	uterus
	Id, Id1 (human)		1		20q11					Brn3a, EWS/FLI-1, IL1, fumagillin, LPS, BMP2, estrogen, PDX1
	Id2 (human)		L		2p25	promote				FKHR, doxorubicin, AP-1, Egr1, IL4, TGFb, BMPs, Notch, estrogen, TCR, PDX1, UV	NK, regulate IgE
	Id3 (human)		L		1p36.13-p36.12	mediate				TGFb, BMPs, AdV, PDX1	Thy
	Id4 (human)				6p22-p21	promote					Thy
	HES1, HRY (human, Dm)		1		3q28-q29			bHLH/ORANGE		FKHR, endostatin
	HES6 (human)				2q37.3
	HES7 (human)				17p13.1						spleen
	Hey1, CHF2, CHF-2, HERP2, HESR1, HRT-1 (human)				8q21			bHLH/ORANGE		HNF4a, Notch, Ret, endostatin, Pg	lung, brain
	Hey2, GRL, HERP1 (human)		L		6q22.2-q22.33					Notch	(brain)
	HeyL (human)				1p34.3					Notch
	DEC1, Stra14, BHLHB2 (human)				3p26
	DEC2, SHARP, BHLHB3 (human)				12p11.23-p12.1						brain, spinal chord
	ASCL4 (human)				12q24.11
	AP-4, TFAP4 (human)				16p13
	MESP1 (human)				15q26.1						prostate
PAH	Sin3a (human, mouse, Dm, Sp)				15q23		Mad, MeCP2, HDACs, p53, Rp8, TEL, AdV E1B55K	PAHx3		serum	oocyte
	Sin3b (human, mouse)				19p13.12

Group	Name	Element	KO	gene	locus	Apoptosis	Binding Partners	Structure	3D	Upstream regulators	memo
bZip	c-Jun (human, mouse, rat, chicken, quail, canary, frog, fugu), dJRA(fly)	AP-1	L	1,2	1p32-p31	induce/protect	c-Fos, GILZ, PU.1, Jab1, COP1	bZip CD3	L	AP1, ATF1, Smad3/4, EGF, IGF-I, TNF, IL1, IL1b/IFNg, NGF, IGF1, TGFb, TSH, RA, E1A, mos, erbA, vRel,IL15, CD3/28, PMA, Tprim, EDA, GM-CSF, GnRH, IGF1, AgII, ET-1, CRF, LPS, KF1B, b-glucan, Ct, Hp, Pa, Sa, MVA, Wnt3a, c-Myc, C/EBPa, estrogen, D3,  PDX1, P2Y2, JAKs, Erk1/2, MPTP, AmB, UV, O stress,  hypoxia, NO, heat shock, KCl	targets, JNK substrate
	JunB (human, mouse, rat, fugu, carp)	CRE, (AP1)	L	1	19p13.2	inhibit?	Fra1	bZip		NF-kB, Smads, Mitf, c-Myc, CLOCK, Tprim, BCR, TCR/CD3/CD8/28, PMA, TNFa, RANKL, IL1, IL-6, IL8, IL10, IL13, IL15, v-Src, TGFb, activin, GnRH, FSH, activin, BMPs, LIF, irrad., UVA, UVB, M-CSF, G-CSF, PDGF, FGF2, GH, insulin, ET-1, Subst.P, LPS, Ct, Hi, Hp, Lm, Sa, IFNg, HCV, RSV, AdV, HHV8, MVA, Erk1/2, RA, PPARa, PDX1, Cannabinoid, YopP, ER, IKKs, TRAF2/TRAF5, hypoxia,ethanol	targets
	JunD(human, rat, chicken,)		L	1	19p13.2	inhibit				AP1, LPS, TRAIL, CD3, Nef, IFNg, UV, PTEN	targets
	c-Fos (human, mosue, rat, G.hamster, C. hamster, bovine, pig, sheep, cat, chicken, quail, frog, fugu, goldfish, carps, salmons, Tf)	AP-1	L	1	14q24.3	induce/(-)	Jun, ATF2,NF-ATp, GILZ	bZip	L	STAT3, STAT5, Mitf, Elk, CREB, AP1, TNFa, RANKL, CD40, EDA, Fas, PMA,Tprim, CD3, D3, serum, Erk1/2, M-CSF, LPS, Sa, St, Pa, Hp, UV, g-irrad, NO, O stress, IL1, IL3, IL8, GM-CSF, FSH, GH, fumagillin, PTH, PTHrP, AgII, Subst.P, ET-1, TGFb, IGF1, MIP3, CREB, SRF, FVIIa, Hgs, JAKs, TAK1, PAK1, Tec, Rsk, Akt, HPV11, RSV, Nef, MPTP, Rac2, irrad, hypoxia, NO, estrogen, LiCl, KCl
	FosB, GosB (human, mouse, rat, dog, fugu)		L		19q13.32					AP1, Tprim, GnRH, VEGF, Thrombin, fumagillin, ethanol, LiCl, camptothecin	dFasB targets
	CREB (human, mouse, rat)	CRE, cast	L	1	2q32.3-q34	inhibit	ACT	bZip	1	AP1, TNFa, sIL6R, CD40, b-glucan, O stress, nicotine, MSK1, MSK2, ATM	SUMO, targets
	ACT, ICER (human)				6q16.1-q16.3		CREB	LIMx4		IFNg, CK2, PTH, CREB
	CREM (human, mouse, rat, dog)		1		10p12.1-p11.1	inhibit		bZip		PMA,CD3&IL2, FSH, GnRH, PTH, CRF, estrogen, NcoRi, RA, Wnt3a, FceRI
	LZIP, CREB3 (human)				9pter-p22.1		HCFC1
	CRE-BPa (human)				7p15					PMA
	CREB-H (human)				19p13.3			bZip
	DBP (human)				19q13.3					CLOCK
	ATF1(human, mouse)				12q13	inhibit		bZip		Pax6, MSK1, MSK2, DIM, I3C, RSV, estrogen
	ATF3 (human)				1q32.2	accelerate/inhibit		bZip		p53, GnRH, endostatin, fumagillin , CRF, stress, NGF, VEGF, Thrombin, Ca2+, DNA damage, PDX1, UV, KF1B, Hp, Lm, Ye, dsRNA, AdV, JNK, E2F1, Egr1, GR, D3, estrogen	JNK substrate, T. repressor of CREB etc
	SNFT (human)				1q32.2
	JDP2 (human)				14q24.2	inhibit		bZip
	B-ATF, BATF, SFA2 (human)				14q24.3		c-Jun, JunB, JunD, IFP35			NF-kB,  LPS, G-CSF, IKKg, TIMP1	lymphocytes
	ATF2, CREBP1, CREB2 (human, bovine)	CRE	L		2q32	(inhibit)	c-fos, GABAbR, TIP49b			MITF, Sm, progesterone
	ATF4, CREB2, TAXREB67 (human)		L	1	22q13.1	(inhibit)	Tax, NRF2, GABAb1	bZip		IRF4, Mitf, NRF2, c-Myc, Stat4a, TNFa, IL1, sIL6R, MV, Ct, Ma, PMA,estrogen, UVB, NO, Epo, TSH, RSK2
	ATF5, ATFx (human)				19q13.3	inhibit	GAGA(B)-R	bZip		LPS, CREB, estrogen
	ATF6 (human)				1q22-q23			TM?/bZip		RANTES, TIMP1	ER stress
	ATF7, ATFa (human, mouse, rat)				12q13			bZip		c-Myc
	C/EBPalpha, CEBPA (human)		L		19q13.1		CDK2, CDK4, PIASy, UBC9			leptin, c-Myc,  MTF1, Lyn	liver, SUMO
	NF-IL6, TCF5, IL6DBP, LAP, C/EBPbeta (human)	C/EBP	L		20q13.1	induce/inhibit	T(T/G)NNGNAA(T/G), HSP1, HDAC1	bZip		NF-kB, WT1, c-jun,ATF2, c-Myb, NRF2, CREB, Tprim, IL1b/IFNg,M-CSF, IL6, RA,LPS, Hi, Pg, FSH, PTH, IL10, IKKs, IKKi, HGF, BMP2, ER stress, leptin	APCs, NK, placenta, targets
	C/EBP gamma (human)				19q13.12
	C/EBP delta, CRP3, CEBPD (human)	C/EBP	1		8p11.2-p11.1	(inhibit)/(-)		bZip		NF-kB, PPARa, TNFa, IL17, LPS, Lm, PTH, RA, IKKs, IKKi, BMP2, leptin, Ye, HHV8
	C/EBP epsilon, CRP1, CEBPE  (human)		L		14q11.2	(inhibit)		cc/bZip
	CHOP, GADD153, DDIT3 (human)		L		12q13.1-q13.2	mediate		bZip		AP-1, C/EBPs, Ets1, FLI1, IRF4, PPARg, NF1, c-Myc, NF-kB, ATF2, ATF3, Epo, irrrad, DNA damage, 15-d-PGJ(2), O2 stress, ER stress, hypoxia, NO, UVB, CK2, TRAF7
	NFIL3, E4BP4(human)			1	9q22.1-q22.3	(inhibit)		bZip		NF-AT, STAT3, IL4, IL12, IL10, insulin, PTH, CRF, TGFb, LPS, HHV8, hypoxia, Ca2+, PMA, PTEN, cantharidin, HHT
	Fra1, FosL1 (human, mouse, rat)		L		11q13		USF, JunB	bZip		NF-kB, c-Myc, TNFa, IL1, RANKL, ET-1, LPS, b-glucan, Ct, HHV8, M-CSF, GnRH, AgII, gastrin, insulin, IKKs, LY294002, Epo., UVA
	Fra2, FosL2 (human, mouse, chicken, fugu)				2p23-p22			bZip		FSH, IL15, TCR/CD3, PMA, IL5, bact., sIL6R, HHV8, estrogen
	OASIS, BBF-2 (human)				11q11.2
	NRF1, alpha-Pal  (human, mouse)		1		7q32	mediate				LPS, cantharidin
	NF-E2 p45 (human, zebrafish)	E2	L		12q13		MafG, MafK			NF-kB, GATA1, IGF1, ARNT2	erythroid
	Nrf1, TCF11, NFE2L1 (human, mouse)		L		17q21.3		MafG,			estrogen
	Nrf2, NFE2L2 (human, mouse, rat,)		L		2q31	protect	MafG,	ATF4		TNF,IL1, progesterone	casp, O stress, targets
	Nrf3, NFE2L3 (human, mouse)		1		7p15-p14		MafK			MVA
	c-Maf (human, mouse, rat, zebrafish, fly, moskito)		L		16q22-q23	induce				NO, IL13	NK, T, kidney, lens
	MafA (human, mouse, rat)
	MafB, Kreisler, KRML (human, mouse, rat, chicken, frog), valentino (zebrafish)		1, kr		20q11.2-q13.1						APCs, NK
	MafF (human, mouse, rat, chicken)		1		22q13.1					TNFa,  VEGF, Thrombin, hypoxia, HHV8, Ye	placenta
	MafG (human, mouse, chicken)	MARE	L		17q25		NF-E2, NRF1, NRF2,		1	NRF2, MVA
	MafK, NF-E2 p18  (human, mouse, rat, chicken)		L		7p22					Tprim
	HLF (human)				17q22			bZip			brain
	TEF (human)				22q13.2			THAD/PAR/bZIP
	XBP1 (human, mosue, rat, frog, zebrafish)	X	L		22q12.1					IRE1, TIMP1
	Bach1 (human, mouse)		1		21q22.11		NF-E2	BTB/bZip		Sp1	B
	Bach2 (human, mouse)		1		6q15	promote	NF-E2	BTB/bZip		estrogen	B, T, fetal brain, class switching
	NRL (human, mouse)		1		14q11.1-q11.2						retina
	AIbZIP (human, mouse, rat)				1q21.2					androgen
HOX	Msx1 (human, mouse, rat, bovine,)		L	1	4p16.1			HOX	1	BMP4, IL13
	Msx2, HOX8.2 (human, mouse, rat, dog, chicken, quail)		1,h	1	5q34-q35	induce		HOX		BMP4, NRF2, Foxc1, Pax3, Pg
	PAX2 (human)		L		10q22.1-q24.3	inhibit				Egr1	kidney, targets
	PAX3 (human)	cast	L	1	2q35	inhibit		PAX/HOX	1	Akt, FGF10
	Pax5, BSAP (human)		L		9p13		Daxx			CD40	targets
	Pax6 (human)				11p13					GR, Ct
	PAX8, Aniridia (human)		L		2q12-q14	inhibit		TTF1
	Pbx1, PRL (human)		1		1q23						erythroid
	Pbx2, HOX12 (human)				6p21.3						hemato.
	Pbx3 (human)				9q33-q34
	PDX1, UF1, PDX1, IDX-1, MODY4, STF-1, IPF1 (human)				13q12.1	inhibit?/(-)?				HSV1	targets
	TTF1, TITF1, BCH, BHC, T/EBP, NKX2A, TTF-1, NKX2.1 (human)		1		14q13	inhibit?		GATA6, PAX8, RARs, BR22, TAZ, NFATs, DREAM		Oct1, HNF3a, TSH, PKA, MST2	thyroid, lung
	Csx, NKX2-5 (human)		L		5q34	regulate?		CAL,			heart
	PMX1, PRX1, PRRX1 (human)				1q24
	PMX2, PRX2, PRRX2 (human)		1		9q34.1					LPS	thyroid, lung, targets
	PROX1 (human)		L		1q32.2-q32.3					RANTES	lymphatic endothelial cell
	HOX3, HOXC8 (human)				12q13.3						targets
	HOXD1, Hex4, Hox4G (human)				2q31.1					Brn3a	dorsal  ganglia, trigeminal
	HoxD9 (human)				2q31.1					estrogen
	HoxD10 (human)				2q31.1						targets
	HoxD11, HOX4F (human)				2q31.1					ErbB4
	Hoxa5 (human)				7p15-p14	induce				estrogen	adrenal, lung
	Hoxa13 (human)		1		7p15-p14	(inhibit)
	NOBOX, OG2 (human)		1		7q35						folliculogenesis
	LHX1 (human)				17q12			LIMx2/HOX		RANKL
	HLX, HB24, HLX1 (human)