Transcription Factors
 

• NF-kB/I-kB/NF-AT

target element: GGGRNYYYCC
 

On-line Review

Review issue of NF-kB in Oncogene (1999)
NF-kB activation by Ghosh S, May MJ, Kopp EB (Annu Rev Immunol 1998), Baeuerle & Baltimore (Cell 1996), Richmond (Nat Rev Immunol 2002), Li & Verma (Nat Rev Immunol 2002)
proteasome by DeMartino GN, Slaughter CA (J. Biol. Chem. 1999)
PPARg by Willson et al. (Annu Rev Biochem 2001)
Transcriptional regulation during B cell development by Henderson & Calame (Annu Rev Immunol 1998)
Transriptional Coactivator by Tjian et al. (Annu. Rev. Biochem. 2001)

Rel/NF-kB Transcription Factor Web Site by Gilmore T.D. (Boston Univ)

Other Transcriptional Apoptosis Regulators
(See NFkB and Apoptosis Regulators, Kinases, too)
 
 

Group	Name	Element	KO	gene	locus	Apoptosis	Binding Partners	Structure	3D	Upstream regulators	memo
Ces	ces-1(C.elegans, C.b.)		1	1		inhibit		ZnF(Snail)
	ces-2(C.elegans)		1	1		induce		bZIP(PAR)
	ces-3(C.elegans)		1
Zn	SLUG(human, mouse), SNAI2,  SNAIL(D.m.)			1	8q11	inhibit		ZnF		PAX3-FKHR, MyoD, BMP2, HHV8	epithelial, adipocyte etc
	SNAI1 (human)				20q13.1					AdV
	Requiem, REQ (human, mouse), d4			1	11q13	inhibit		ZnF		D3
	RYBP, DEDAF, YY1AF2, YAF2 (human, mouse)			1	3		Casp8, Casp10, FADD, E2Fs, YY1	RING		Ma, ribavirin
	zf3, ZNF319 (human, mouse)				16q13	induce		ZnFx15
	PAG-3 (C.e.),  Gfi1 (human, rat)	IP	L	1	1p22	inhibit		SNAG/ZnFx7		BRN3C
	Egr1, Krox24, Zif268 (human, mouse)		L	1	5q31.1	mediate/inhibit	RelA		L	CREB, AP1, WT1, Egr1, ARNT2,  FKHR, Akt, PKCb, hypoxia, irrad., BRCA1, Ct, Ec, Ld, Sa, St, Tg, RSV, TNFa, TRAIL, RANKL, LPS, IFNg, IL5, CXCL9, IL1, GM-CSF, GnRH, VEGF, HPV11, FVIIa, IgM, TCR/CD3,  Notch, endostatin, fumagillin, insulin, IGF1, UV, ER stress, NO, O stress, GH, AgII, ET-1, PGE2, PMA, CsA, ethanol, heat shock, hypoxia, ER, PDX1, BMP2, Blimp1, OX-CA, KCl	targets
	Egr2, KROX20 (human)		1	1	10q21.1-q22.1	induce		ZnF		NF-AT, IL5, Fas, TCR/CD3, GnRH, VEGF, insulin, Lm, Tg, PTEN, estrogen, Rac2, D3
	ZNF365 (human)				10q21.2					TNFa	brain
	Egr3 (human)		L	1	8p23-p21	enhance		ZnF		NF-AT, c-Myc, IL5, IL8, VEGF,  Thrombin, estrogen, HHV8	brain
	Egr4, NGFI-C (human)	GSG	1		2p13					NGF, CREB
	Sp1 ( human)	cast			12q13.1	regulate			L		casp
	Sp3 (human)									phenytoin
	FKLF2, RFLAT1, KLF13 (human)				15q12		CBP/p300, PCAF				Erthroid, NK, APCs, B, T,
	TIEG (human)				8q22.2	induce		ZnFx3		TGFb, GR, TNFa, Wnt3a, HHT
	WT1 (human)		L		11p13	inhibit/induce	Ciao1			HOX11, c-Myc, PEA3, AP1, HNF4a, LIF, HBx, Vasopressin, RA	targets
	Zac1, Zac, Lot1, PLAGL1 (human)				6q24-q25	induce		ZnFx5
	Ikaros, IK1, Lyf1, ZNFN1A1 (human)		1		7p13-p11.1	regulate		ZnFx6		Tprim, LPS, VDR, IL5	hemato.
	H-plk (human)				7q11.21			ZnFx10		HCV core
	ZNF92, TF12, HPF12 (human)				7q11.21					CSBG	hemato.
	ZNF148, ZBP89 (human)				3q21	induce				FSH	hemato.
	ZNF24, KROX17 (human)				18q12					Ct	lymphocytes
	ZNF35, HF.10 (human)				3p22-p21					GR, insulin, IGF-II, UVB
	ZNF36 (human)				7q21.3-q22.1					RANKL, IL2, estrogen, GR, CREB, IGFBP2, HHV8
	ERF1,  ZFP36L1, BRF1, cMG1, ERF-1, Berg36, TIS11B, RNF162B (human)				14q22-q24		Sim1			PMA, EGF, IL4, ARNT2
	ZNF76 (human)				6p21.3-p21.2			ZnFx7			Sumo
	ZNF165, LD65 (human)				6p21.3			ZnFx5		IL8	testis
	WIZ (human)				19p13.1			ZnFx11		LPS
	LKLF, KLF2 (human)				19p13.1					TRAF2, PDGF	B, T, NK, APCs
	ZK1, ZNF443 (human)				19p13.2	enhance					preB
	ZNF43, HTF6 (human)				19p13.1-p12					AmB
	ZNF85 (human)				19p13.1-p12
	ZNF160, F11, HZF5, KR18, HKr18 (human)				19q13.3-q13.4			KRAB/ZnFx20		MeDNA
	ZNF91, HPF7, HTF10 (human)				19p13.1-p12			KRAB/ZnFx32		Ma, RA, GM-CSF, IGFBP2	brain, hemato.
	ZNF93, TF34, HPF34, HTF34 (human)				19p13.1-p12					ARNT2
	ZNF146, OZF (human)				19q13.1					c-Myc, progesterone	hemato.
	EKLF, KLF1 (human)				19p13.13-p13.12					Subst.P, LPS, GATA1, IL5	erythroid, endothelial
	ZNF382 (human)				19q13.13					Cdx2
	MZF1, ZNF42 (human)				19q13.2-q13.4					RA, EV71
	ZNF124, ZK7 (human)				1q44	inhibit				VEGF	erythroid
	ZNF125, HZF3 (human)				11q23.1-q23.2					FSH, b-catenin
	ZNF128 (human)				11q23.1-q23.2		TIF1beta
	PLZF, ZNF145 (human)		L		11q23.1	inhibit					lung, targets
	ZNF131 (human)				5p12-p11			ZnFx6		TNFa, Ct	hemato.
	ZNF132 (human)				19q13.4					IGFBP2
	ZNF133 (human)				20p11.23-20p11.22					HHV8
	ZNF134 (human)				19q13.4					IGFBP2	lymphocytes
	ZNF137 (human)				19q13.4					estrogen
	ZNF350, ZFQR, ZBRK1 (human)				19q13.41		BRCA1			DNA-damaging reagents
	ZNF143, SBF (human)	SPH			11p15.4	regulate?
	ZNF177 (human)				19p13.2					endostatin, fumagillin
	ZNF207 (human)				17q11.2			ZnFx2		SCF
	ZNF208 (human)				19p12
	ZNF408 (human)				18q23						bm
	KLF5, BTEB2 (human)		1		13q21.33		RAR			FKHR	epithelial
	KLF7, UKLF (human)				2q32					RANTES
	KLF4 (human)		L		9q31					endostatin, GnRH, estrogen	APCs, skin barrier
	BTEB, BTEB1, KLF9 (human)	GC box			9q13					Stat4b, insulin, IGF-II, PDGF, endostatin
	ZNF216 (human)				9q13-q21		ZNF216, IKKg, RIP, TRAF6	ZnF(A20)/ZnF(AN1)		LPS, IL10, TRRAP, PDGF	APCs, inhibit NF-kB
	ZNF217, ZABC1 (human)				20q13.2					estrogen	hemato.
	ZNF83, HPF1 (human)				19q13.3						lymphocytes
	ZNF257 (human)				19q13
	ZNF215 (human)				11p15.4			LER/KRAB/ZnFx4		TNFa
	ZNF274, ZFP2 (human), NRIF1(mouse)		1		19qter	(induce)	NGFR(p75NTR)	KRAB/LER/KRAB/ZnFx5		TCR	lymphocytes
	ZNF33A (human)				10p11.2			KRAB/ZnFx16		estrogen
	MOK2, ZNF239 (human)				10q11.22-q11.23		DNA, RNA			IGFBP2
	CIZ, NMP4, ZNF384 (human)	cast			12p12		CAS,				Bmp/Smad
	GLI1 (human)				12q13.2-q13.3					Brn3b, ARNT2
	ZNF205, ZNF210 (human)				16p13.3					IGFBP2
	ZF5, ZFP161 (human)	GSGCGCGR			18pter-p11.2		ZF5	BTB/ZFx5		D3
	ZNF238 (human)				1q44-qter					HHV8	cerebellum
	ZIC2, HPE5 (human)		L		13q32						cerebellum
	ZIC5, Opr (human)				13q32.3
	ZIC3, HTX1 (human), odd-paired (Dm)		hlx		Xq26.2						cerebellum
	ZNF288, HOF, DPZF (human)				3q13.2			BTB/ZFx5		HOX11
	SZF1-1, SZF1 (human)				3p21					AdV
	ZIC1 (human)		L		3q24			ZFx5		Bmp2	cerebellum
	ZIC4 (human)				3q24						cerebellum
	Evi1 (human)				3q24-q28			ZFx11		HCV core	B, T
	Bcl6, LAZ3, ZNF51 (human)	cast	L		3q27		N-CoR, SMRT, p300, HDAC1	BTB/ZFx6		HHV8, TNFa, FKHR, TIMP1	myeloid
	WIG1, PAG608 (human)				3q26.3-q27	mediate		ZnF(U1)x3		p53, BRCA1, LPS
	HIVEP1, PRDII-BF1, ZNF40, HIV-EP1, MBP-1 (human)				6p24-p22.3	induce		ZFx2/ZF/ZFx2		TNFa, LPS
	ZNF318 (human)				6pter-p12.1					TNFa	hemato.
	HIVEP3 (human), schnurri (Dm)				1p34	regulate
	Fliz1, LOC84524 (human)				2q12.3	induce
	Rp8, PDCD2 (human, mouse, rat)				6q27		N-CoR, Sin3A	ZnF(MYND)		Bcl6, Irradiation, RA, Dex.	hemato.
	ZPR9 (human)				5p15.1	induce	B-Myb
	Krox1, ZNF10 (human)				12q24.33		TIF1beta
	KRAZ2, ZFP68 (mouse)						TIF1beta				repressor
	Mzf22, ZFP87 (mouse)						TIF1beta
	KLF3 (human)							ZFx3		TCR, DEX	erthroid
	Bcl11a (human)		1	1	2p15			ZFx6			B, DC
	Bcl11b (human)		1	1	14q32.31			ZFx6			ab T cells
	FLJ14299 (human)				8p11.23			ZF		AdV
	MAX, ZF87, PUR1, SAF-1 (human)				16p11.2			ZFx6
	ZNF267, HZF2 (human)				16p11.2					AP1, TNFa	preB
	ZNF483, HIT-10 (human)				9q32					Cdx2
	AIRE (human)				21q22.3
RING	For ZNF144, 147, 313, 173, 179, 364, see RING proteins
GATA(Zn)	GATA1 (human)	GATA	L	1	Xp11.23	inhibit			list	Ets1,Ets2, Fli1, Tprim, SCF, Notch	erythroid, endothelial, targets, casp
	GATA2 (human)	GATA2	L		3q21		PIASy			GATA1, GM-CSF, Egr1, ARNT2, IL3, staurosporine	haematopoietic, SUMO
	GATA3 (human)	GATA3	L		10p15	promote				BCL6, Brn3a, Tprim, IL4, IL27, TGFb, Fliz1, ribavirin	T, NK, placenta
	GATA4 (human)		L		8p23.1-p22	inhibit				PMSG, estrogen, FSH , IL18, Akt	heart (endoderm)
	GATA5 (human)		1		20q13.33						genitourinary
	GATA6 (human)		1		18q11.1-q11.2			TTF1		PMSG, estrogen	adrenal,  heart (endoderm)
	TRPS1 (human)		1		8q24.12
C5HC2	Jumonji, JMJ (human)				6p24-p23					LPS
DHHC	ZDHHC8, ZNF378 (human)				22q11.21			TM/DHHC/TM		TNFa, NF-kB
	ZDHHC14 (human)				6q25.3			TM/DHHC/TM		AIRE
AREB6	AREB6, TCF8 (human)				10p11.2					Egr1, VEGF, Thrombin

Group	Name	Element	KO	gene	locus	Apoptosis	Binding Partners	Structure	3D	Upstream regulators	memo
NR (ZnF+Ligand BD)	RORalpha, ROR1 (human)				15q21-q22					Stat4a, HOX11	T, NK
	RORbeta, ROR2 (human)				9q22
	RORgamma, ROR3, RORC (human)		1	1	1q21	inhibit		NR			liver, LTi
	TR3, HMR, NGFI-B, GFRP1, Nur77, NP10, NR4a1 (human)	AAAAGGTCA		1	12q13	induce/inhibit	Bcl2	NR		Akt, PPARg1, LPS, Lm, BRCA1,  TCR, Nef, SDF1, KiSS1, GnRH, CRF, PTH, endostatin, estrogen, DEX, RARa, CREB, Cabin1, MEF2, HDAC7, hypoxia, camptothecin, AdV, MEKK1	adrenal cortex, targets
	Nurr1, NOT, RNR1, HZF-3, TINUR, NR4A2 (human)		1		2q22-q23					TCR, CRF, AgII
	PPAR alpha, PPARA (human)		L		22q13.31					AP1	targets
	PPAR gamma, PPARG (human)		L		3p25	promote	15dPGJ(2)	NR		BMPs, leptin, D3, Egr1, IL13, ALA	targets
	PPAR delta, PPARD (human)		L		6p21.2-p21.1	inhibit?	RA			TNFa, 15-LOX-1
	CSMF, Nor-1, MINOR, NR4A3 (human)				9q22	mediate		NR		PTH, Ask1, CREB , HOX11, IL1, IL8, Lm,  MDP,  LPS,  PMA	adrenal cortex
	LXRa, NR1H3 (human)		L		11p11.2		RXRa, GW3965			Mt	adipocyte, liver, 9cRA
	RXRa (human)		1		9q34.3	induce	cRA, RNF8		L	estrogen	erythroid
	RXRb (human)		1		6p21.3					RA, Subst.P, b-glucan, Hi
	RARa (human)				17q12	induce	SMRT, BAG1			IFNa,  IL5, c-Myc, WT1, palmitate, UVB	(myeloid)
	RARb (human)		1		3p24	promote				c-Myc, Epo, RA, PPARg	targets
	RARg (human)				12q13	induce				UVB, RA, insulin, Cp, TIMP1
	T3Ra, THRa, EAR7,erbAa (human)				17q11.2	induce/inhibit?	T3, N-CoR, SMRT	NR		PTH, D3, Nur77
	T3Rb, THRb, ErbA2, ErbAb (human)		L		3p24.3		SMRT	NR		AgII, Brn3b
	ERalpha, ESR1 (human)		L		6q25.1		SMAD4	NR		VEGF, Subst.P,LPS	uterus, estrogen targets
	ERbeta, ESR2 (human)		L		14q	mediate		NR
	AR (human)		L		Xq11.2-q12		Androgen, SMRT			LPS
	VDR (human)		L		12q12-q14	induce/inhibit	12q12-q14			WT1, D3, TNFa	targets
	GR, GCCR, NR3C1 (human)		1		5q31	mediate	CBP, glucocorticoid, DAP3			A2aR, Notch, HHV8, UVA	targets
	COUP-TFI, EAR3, ERBAL3, NR2F1 (human)		1		5q14		N-CoR, SMRT			IL1	brain
	EAR2, ERBAL2, NR2F6 (human)	TGACCT			19p13.1					Ye
	ELP, SF1, FTZ1, SF-1, AD4BP, FTZF1, NR5A1 (human), fushi tarazu (Dm)		L		9q33					ARNT2
	HNF4a, TCF14 (human)		1		20q12-q13.1			NR		palmitate
	HNF4g (human)				8q13.3-q21.11			NR			salibary gloand
	PXR, SXR, PAR1, NR1I2 (human)				3q12-q13.3					endostatin	liver, targets

 

Group	Name	Element	KO	gene	locus	Apoptosis	Binding Partners	Structure	3D	Upstream regulators	memo
p53	p53(list)	P box, cast	L	1	17p13.1	induce	DNA, GR, Rb, mdm2, Pirh2, LKB1, TFIIH, ERCC2, ERCC3, p62, p36, PIASy, Sin3a, SMN, BLM, securin, nucleolin, HIFa, ICP0, IkBa, SMAD2, Bcl-xL	AD/DB/Oligo/RD	list	c-fos, c-jun, ATF3, NF-kB, Myc,Max, Stat4, Hey1, Hes1, TFAP4, Osr1, NR2F2, SFRS10, Bcl6, WIG1, HIVEP1, IFNa, IFNb, gastrin, CD3, LPS, sBLP, MeDNA, dsRNA, Brn-3a/(-), HBx, EGR1, E2F1, c-Maf, p53, IRF9, SST, NO, TCDD, Mdm2, GADD45a, Chk2, FRAP, ER stress, GSK3b, HIPK2, Pin1, SIR2, NQO1, PLD,  IGF-I, HAUSP, UDCA	targets, JNK
	p73alpha(human),KET(rat)		L	1	1p36	promote(full) inhibit(dN)	DNA, mdm2, PMS2, c-Myc	AD/DB/Oligo	1	p53, p73, E2F1, PKCd, DNA damage, CDC2, CHK1, KCl	targets, E2F-1
	p63(human [ta alpha, ta beta, ta gamma , da alpha, da beta, da gamma], mouse[da alpha, da beta, da gamma, ta* alpha, ta* beta, ta* gamma])		L	1	3q27-q29	promote	DNA, SSRP1	AD/DB/Oligo		mdm2, UVB
	p53/CG10873(D.m.), CEP-1(C.e.)		L	L		mediate	DNA	AD/DB/Oligo		Chk2
	Rb (human)		L		13q14.1-q14.2	inhibit	p53, Cdk9, CMV pp71, DNMT1		L	LPS, Mt, CD40, GATA1, E2F1, p53, CREB, CBP, MyoD, IFNg, IL1a, SST, FSH, RA, NO	casp
	p107 (human)		L		20q11.2		E2Fs, CMV pp71			RA
	p130, Rb2, RBL2 (human)		L		16q12.2	(inhibit)	E2Fs, CMV pp71			TCR, IL1, CD40, BCR, PI3K, Egr1, ARNT2	targets, Ub
p53BP2	53BP2, ASPP2 (human), CG18375(Dm), F46F3.4(Ce)				1q42.1	enhance	p53, NF-kB, Bcl2, YAP, PP1	(RA)/coiled-coil/?/Ank x2/SH3		E2F1,UV	activates NF-kB
	ASPP1, PP1R13B(human)					enhance	p53	RA/coiled-coil/?/Ank x2/SH3
	RAI, iASPP (human)					inhibit	RelA	?/Ank x2/SH3
E2F1	E2F1 (human, mouse, chicken, Ce, Dm, At)	E2F, cast	L		20q11.2	mediate	Rb, DP1, DP2, TRRAP, cyclins, MAGEs, DNMT1, BECA1, TopBP1		L	CDK2, DNA damage, c-Myc, TR3, Hoxd10, IL5, IFNa, IFNb, Rbs, GABPgamma1, flavopiridol, AgII, RARb, RA, UDCA, estrogen, EV71, TIMP1, KCl	targets
	E2F2(human, mouse)		L		1p36	mediate/(-)	Rb		1	MyoD, GR, TGFb
	E2F3(human, mouse)		L		6p22	mediate/(-)	Rb			PMA, AgII, UVA, UVB, VDR, Cdx2
	E2F4(human, mouse)	cast	L		16q22.1	(-)	DP1, p130, p107			CD3/CD28, RANKL
	E2F5 (human, mouse)		1		8p22		p130, p107			RA, UVB, LPS, Sm
	E2F6(human, mouse)				22q11		RYBP
	E2F7 (human, mouse)
	FLJ23311  (human)				11p15.1
	DP1 (human, mouse)	cast			13q34		E2Fs			LPS, S.t., c-Myc,  C/EBPb, IFNg, FSH, heat shock, RA, DIM, I3C, ribavirin, IL5, estrogen, TIMP1
	DP2(human)	cast			3q23					IL15, TCR/CD3

Group	Name	Element	KO	gene	locus	Apoptosis	Binding Partners	Structure	3D	Upstream regulators	memo
HMG	(TCF1), TCF7 (human)		1		5q31.1			HMG		Wnt-1,AIRE, IL12, AP1, PMA, estrogen	Wnt
	TCF3 (human)		1		2		b-catenin	HMG			Wnt, hemato.
	TCF4, TCF7L2 (human)		L		10q25.3		b-catenin, PIASy	HMG		AP1, TIMP1	Wnt
	LEF1 (human)		L		4q23-q25	(inhibit)	b-catenin, PIASy	HMG		TCR, Notch	Wnt, T, SUMO
	TCF1/HNF1/LFB1/MODY3(human)				12q24.2			HMG			Wnt
	HBP1 (human)				7q22-q31			HMG		p38
	SOX2 (human)		L		3q26.3-q27					IGF1, AIRE	brain
	SOX3 (human)		1		Xq26-q27
	SOX4 (human)				6p22.3		syntenin			TNFa,, estrogen, FceRI	DC, bm
	SOX9, CMD1, CMPD1 (human)		1		17q24.3-q25.1	inhibit				TNFa,
	SOX10,DOM, WS4 (human)		1		22q13.1					Cdx2, ARNT2	brain
	SOX11 (human)				2p25					Subst.P, LPS	fetal brain
	SOX15 (human)		1		17p13						bladder
	HMG-I (human)									IFNg, TNFa, IGF1, LMP1, ALK1, irrad, DEX, HIV Vpr, estrogen
HIF	HIF1alpha (human)		L		14q21-q24	mediate	ARNT(HIFb), VHL, p53,	HLH/PASx2/PAC	L	AP1, Egl9, FOXO4, c-Myc, TNFa, IFNa, LPS, Ma	epithelium
	HIF1beta, ARNT  (human)				1q21
PAS	SRC1, NCoA1 (human)	inhibit	L		2p23		PR, ErbA2, JAB1, CIITA	HLH/PAS			NK
	TIF2, GRIP1, NCoA2 (human)	inhibit	L		8q13.2		p300, GR, TR, D3R, RARa, RXRa	HLH/PAS/PAC
	TRAM1, NCoA3, RAC3, ACTR, SRC3, AIB1, pCIP, CTG26, CAGH16, TNRC14, TNRC16 (human)				20q12			HLH/PAS		STAT6	hemato.
	NPAS2 (human)		L		2q11.2			HLH/PAS
TCF	TCF3, ITF1, E12, E47, E2A (human)				19p13.3			HLH		ARNT2	B, erhthroid
	TCF4, ITF2(human)				18q21.1	enhance		HLH			DC
	TCF12/HTF4(human)				15q21			HLH		c-Myc	hemato.
	bHLH-EC2, Meso1, TCF15 (human)				20p13					estrogen	hemato.
	TCF21 (human)		L		6pter-qter						lung
HES5	HES5 (human, mouse)				1			HLH		CREB	brain
IPT	EBF, OLF1, COE1 (human)		1		5q34			IPT/HLH		E12, CD40, Brn3b
	EBF2 (human)				8p21.2			IPT/HLH
	EBF3 (human)				10q26.3			IPT/HLH			brain
	EBF4  (human)				20p13			IPT/HLH
bHLHZip	c-Myc(human)	E box		1	8q24.12-q24.13	induce	Max, p73, p107, TRRAP, Tiam1, MM-1	AD/bHLHZip	1	IL1, IFNg, TNFa, RANKL, CD40, BAFF, TACI, TCR, CD3/28, PMA, LPS, Hp, Ma, Tg, MVA, HBx, TGFb, M-CSF, CD30, Wnt-3A, FSH, glucose, ET-1, ER stress, UVA, UVB, C/EBPa, GATA1, Pitx2, c-Myc, WT1, NF-kB, AP1, Smad3, E2F4, LEF1, ER, ARF, FVIIa, CARP1, g-irrad,Epo, TSH, MKK7, MEKK1, CsA/FK506, sIL6R, NO, ER, estrogen, RA, BRCA1, IL15, CD9, ALK1, Bcl6, AmB, cantharidin, HHT, PAK2	targets, Ub, calpain
	N-Myc (human)	E box	1	1	2p24.1	inhibit	Max, NMI	bHLHZip		IL1b, TRAIL, LPS, IKKg, S.t., LPS, Mad1, Pax5, WT1, E2F, RA,	targets, Ub
	L-Myc, MYCL1 (human)			1	1p34.3	inhibit	Max	bHLHZip		NF-kB, c-Myc, LPS, IL10, RA, IKKs
	L-Myc2, MYCL2 (human)				Xq22-q23					ALK1
	Max (human)		1	1	14q23	promote	Myc, Mxi, MNT, Mad, MLX	bHLHZip	L	CGRP, D3, adrenomedullin	hemato.
	MLX, TCFL4 (human)			1	17q21		Max	bHLHZip
	MNT, ROX(human)		1	1	17p13.3		Max	bHLHZip
	Mad (human)		1	1	2p13	promote	Max, Sin3a	bHLHZip		LPS, (p38), GATA1, estrogen, Egr1, IL12	myeloid, targets
	Mad3, MXD3 (human, mouse)		1		5q35.3	(inhibit)	Max	bHLHZip			erythroid, targets
	Mad4, MXD4 (human)				4p16.3					GR, OX40
	Mxi1 (human)		1	1	10q25		Max	bHLHZip		hypoxia, LPS	erythroid
	WBSCR14 (human)				7q11.23
	USF1 (human)				1q22-q23
	USF2 (human)		L		19q13					SCF, ErbB2, IL5
	TFE3 (human)		1		Xp11.22					IFNa
	TFEC (human)				7q21.2-q21.3						myeloid, APCs
	MGC2383 (human)				5q35.3						erythroid
	Dermo1 (human)				2q37.3
	MyoD, Myf3 (human)		L		11p15.4					EV71	NK, (muscle)
	myogenin, MYF4, MYOG (human)				1q31-q41					IGF1/Akt
	Myf5 (human)		L		12q21					estrogen, BMP2	(muscle)
	MondoA, MIR (human)				12q21.31						hemato.
	SREBP1, SREBF1 (human)			1	17p11.2		Max, DNA	AD/bHLHZip/TMx2			casp, targets
	SREBP2, SREBF2 (human)				22q13						targets
	DEC1, BHLHB2, CR8 (human)				3p26	inhibit		bHLH		IL2, IL4, VEGF, TGFb, Thrombin, Sa
	neurogenin 3, NEUROG3 (human)				10q21.3
	ASCL3 (human)				11p15.3
	ARNTL (human)				11p15
	Math1(human), atonal (Dm)				4q22	(inhibit)		bHLH			large intestine, hair cells in the mouse inner ear
	Atoh2, NEX1M, Math2, NEUROD6 (human)				7p15.3					CREB	brain
	MITF (human)		WS2, L		3p14.1-p12.3	inhibit/promote	UBC9, PIASy	bHLHZip			uterus, targets
	MyoR, ABF1, musculin , MSC (human)		1		8q21					Brn3a	preB
	HAND1 (human)		L		5q33						embryonic
	HAND2, dHAND, Thing2 (human)		1		4q33						subthalamic nucleus
	neuroD1, BETA2, BHF-1, NIDDM (human)		1		2q32						cerebellum
	neuroD2 (human)				17p13.1						brain
	neuroD6 (human)				7p15.1						brain
	neurogenin 1, NEUROG1, AKA, ngn1, Math4C (human)		L		5q23-q31
	neurogenin 2, Atoh4, ngn-2, Math4A, NEUROG2 (human)				4q25						preB
	neurogenin 3, ngn3, Atoh5, Math4B, NEUROG3 (human)				10q21.3
	Math1, ATH1, HATH1,  ATOH1 (human)		L		4q22
	PTF1A, PTF1-p48 (human)				10p12.31						pancreas
	ATOH7 (human)				10q22.1
	ATOH8, HATH6 (human)				2p11.2						liver, lung, thyroid
	OLIG1 (human)		L		21q22.11						brain, spinal cord
	OLIG2 (human)		1		21q22.11						brain, spinal cord
	OLIG3, Bhlhb7 (human)				6q23.2
	TAL1, SCL, TCL5 (human)		1		9q32	inhibit					bone marrow, casp
	LYL1 (human)				19p13.2-p13.1						APC, B, bone marrow
	NHLH1, HEN1, NSCL, NSCL1 (human)		1		1q22						brain, spinal cord
	NHLH2,NSCL2, HEN2 (human)		1		1p12-p11
	Beta3, CAGL85, TNRC20, BHLHB5 (human)				8q13
	FERD3L, NATO3, N-Twist (human)				7p21.1
	MIST1 (human)		1		7q22.1						prostate, salivary gland, thyroid
	twist-1 (human, mouse, zebrafish)		1		7p21.2						placenta, uterus
	twist-2, DERMO1 (human)		1		2q37.3					NF-kB, TNF	uterus
	Id, Id1 (human)		1		20q11					Brn3a, EWS/FLI-1, IL1, fumagillin, LPS, BMP2, estrogen, PDX1
	Id2 (human)		L		2p25	promote				FKHR, doxorubicin, AP-1, Egr1, IL4, TGFb, BMPs, Notch, estrogen, TCR, PDX1, UV	NK, regulate IgE
	Id3 (human)		L		1p36.13-p36.12	mediate				TGFb, BMPs, AdV, PDX1	Thy
	Id4 (human)				6p22-p21	promote					Thy
	HES1, HRY (human, Dm)		1		3q28-q29			bHLH/ORANGE		FKHR, endostatin
	HES6 (human)				2q37.3
	HES7 (human)				17p13.1						spleen
	Hey1, CHF2, CHF-2, HERP2, HESR1, HRT-1 (human)				8q21			bHLH/ORANGE		HNF4a, Notch, Ret, endostatin, Pg	lung, brain
	Hey2, GRL, HERP1 (human)		L		6q22.2-q22.33					Notch	(brain)
	HeyL (human)				1p34.3					Notch
	DEC1, Stra14, BHLHB2 (human)				3p26
	DEC2, SHARP, BHLHB3 (human)				12p11.23-p12.1						brain, spinal chord
	ASCL4 (human)				12q24.11
	AP-4, TFAP4 (human)				16p13
	MESP1 (human)				15q26.1						prostate
PAH	Sin3a (human, mouse, Dm, Sp)				15q23		Mad, MeCP2, HDACs, p53, Rp8, TEL, AdV E1B55K	PAHx3		serum	oocyte
	Sin3b (human, mouse)				19p13.12

Group

Name

Element

KO

gene

locus

Apoptosis

Binding Partners

Structure

3D

Upstream regulators

memo

bZip

c-Jun (human, mouse, rat, chicken, quail, canary, frog, fugu), dJRA(fly)

AP-1

L

1,2

1p32-p31

induce/protect

c-Fos, GILZ, PU.1, Jab1, COP1

bZip CD3

L

AP1, ATF1, Smad3/4, EGF, IGF-I, TNF, IL1, IL1b/IFNg, NGF, IGF1, TGFb, TSH, RA, E1A, mos, erbA, vRel,IL15, CD3/28, PMA, Tprim, EDA, GM-CSF, GnRH, IGF1, AgII, ET-1, CRF, LPS, KF1B, b-glucan, Ct, Hp, Pa, Sa, MVA, Wnt3a, c-Myc, C/EBPa, estrogen, D3,  PDX1, P2Y2, JAKs, Erk1/2, MPTP, AmB, UV, O stress,  hypoxia, NO, heat shock, KCl

targets, JNK substrate

JunB (human, mouse, rat, fugu, carp)

CRE, (AP1)

L

1

19p13.2

inhibit?

Fra1

bZip

NF-kB, Smads, Mitf, c-Myc, CLOCK, Tprim, BCR, TCR/CD3/CD8/28, PMA, TNFa, RANKL, IL1, IL-6, IL8, IL10, IL13, IL15, v-Src, TGFb, activin, GnRH, FSH, activin, BMPs, LIF, irrad., UVA, UVB, M-CSF, G-CSF, PDGF, FGF2, GH, insulin, ET-1, Subst.P, LPS, Ct, Hi, Hp, Lm, Sa, IFNg, HCV, RSV, AdV, HHV8, MVA, Erk1/2, RA, PPARa, PDX1, Cannabinoid, YopP, ER, IKKs, TRAF2/TRAF5, hypoxia,ethanol

targets

JunD(human, rat, chicken,)

L

1

19p13.2

inhibit

AP1, LPS, TRAIL, CD3, Nef, IFNg, UV, PTEN

targets

c-Fos (human, mosue, rat, G.hamster, C. hamster, bovine, pig, sheep, cat, chicken, quail, frog, fugu, goldfish, carps, salmons, Tf)

AP-1

L

1

14q24.3

induce/(-)

Jun, ATF2,NF-ATp, GILZ

bZip

L

STAT3, STAT5, Mitf, Elk, CREB, AP1, TNFa, RANKL, CD40, EDA, Fas, PMA,Tprim, CD3, D3, serum, Erk1/2, M-CSF, LPS, Sa, St, Pa, Hp, UV, g-irrad, NO, O stress, IL1, IL3, IL8, GM-CSF, FSH, GH, fumagillin, PTH, PTHrP, AgII, Subst.P, ET-1, TGFb, IGF1, MIP3, CREB, SRF, FVIIa, Hgs, JAKs, TAK1, PAK1, Tec, Rsk, Akt, HPV11, RSV, Nef, MPTP, Rac2, irrad, hypoxia, NO, estrogen, LiCl, KCl

FosB, GosB (human, mouse, rat, dog, fugu)

L

19q13.32

AP1, Tprim, GnRH, VEGF, Thrombin, fumagillin, ethanol, LiCl, camptothecin

dFasB targets

CREB (human, mouse, rat)

CRE, cast

L

1

2q32.3-q34

inhibit

ACT

bZip

1

AP1, TNFa, sIL6R, CD40, b-glucan, O stress, nicotine, MSK1, MSK2, ATM

SUMO, targets

ACT, ICER (human)

6q16.1-q16.3

CREB

LIMx4

IFNg, CK2, PTH, CREB

CREM (human, mouse, rat, dog)

1

10p12.1-p11.1

inhibit

bZip

PMA,CD3&IL2, FSH, GnRH, PTH, CRF, estrogen, NcoRi, RA, Wnt3a, FceRI

LZIP, CREB3 (human)

9pter-p22.1

HCFC1

CRE-BPa (human)

7p15

PMA

CREB-H (human)

19p13.3

bZip

DBP (human)

19q13.3

CLOCK

ATF1(human, mouse)

12q13

inhibit

bZip

Pax6, MSK1, MSK2, DIM, I3C, RSV, estrogen

ATF3 (human)

1q32.2

accelerate/inhibit

bZip

p53, GnRH, endostatin, fumagillin , CRF, stress, NGF, VEGF, Thrombin, Ca2+, DNA damage, PDX1, UV, KF1B, Hp, Lm, Ye, dsRNA, AdV, JNK, E2F1, Egr1, GR, D3, estrogen

JNK substrate, T. repressor of CREB etc

SNFT (human)

1q32.2

JDP2 (human)

14q24.2

inhibit

bZip

B-ATF, BATF, SFA2 (human)

14q24.3

c-Jun, JunB, JunD, IFP35

NF-kB,  LPS, G-CSF, IKKg, TIMP1

lymphocytes

ATF2, CREBP1, CREB2 (human, bovine)

CRE

L

2q32

(inhibit)

c-fos, GABAbR, TIP49b

MITF, Sm, progesterone

ATF4, CREB2, TAXREB67 (human)

L

1

22q13.1

(inhibit)

Tax, NRF2, GABAb1

bZip

IRF4, Mitf, NRF2, c-Myc, Stat4a, TNFa, IL1, sIL6R, MV, Ct, Ma, PMA,estrogen, UVB, NO, Epo, TSH, RSK2

ATF5, ATFx (human)

19q13.3

inhibit

GAGA(B)-R

bZip

LPS, CREB, estrogen

ATF6 (human)

1q22-q23

TM?/bZip

RANTES, TIMP1

ER stress

ATF7, ATFa (human, mouse, rat)

12q13

bZip

c-Myc

C/EBPalpha, CEBPA (human)

L

19q13.1

CDK2, CDK4, PIASy, UBC9

leptin, c-Myc,  MTF1, Lyn

liver, SUMO

NF-IL6, TCF5, IL6DBP, LAP, C/EBPbeta (human)

C/EBP

L

20q13.1

induce/inhibit

T(T/G)NNGNAA(T/G), HSP1, HDAC1

bZip

NF-kB, WT1, c-jun,ATF2, c-Myb, NRF2, CREB, Tprim, IL1b/IFNg,M-CSF, IL6, RA,LPS, Hi, Pg, FSH, PTH, IL10, IKKs, IKKi, HGF, BMP2, ER stress, leptin

APCs, NK, placenta, targets

C/EBP gamma (human)

19q13.12

C/EBP delta, CRP3, CEBPD (human)

C/EBP

1

8p11.2-p11.1

(inhibit)/(-)

bZip

NF-kB, PPARa, TNFa, IL17, LPS, Lm, PTH, RA, IKKs, IKKi, BMP2, leptin, Ye, HHV8

C/EBP epsilon, CRP1, CEBPE  (human)

L

14q11.2

(inhibit)

cc/bZip

CHOP, GADD153, DDIT3 (human)

L

12q13.1-q13.2

mediate

bZip

AP-1, C/EBPs, Ets1, FLI1, IRF4, PPARg, NF1, c-Myc, NF-kB, ATF2, ATF3, Epo, irrrad, DNA damage, 15-d-PGJ(2), O2 stress, ER stress, hypoxia, NO, UVB, CK2, TRAF7

NFIL3, E4BP4(human)

1

9q22.1-q22.3

(inhibit)

bZip

NF-AT, STAT3, IL4, IL12, IL10, insulin, PTH, CRF, TGFb, LPS, HHV8, hypoxia, Ca2+, PMA, PTEN, cantharidin, HHT

Fra1, FosL1 (human, mouse, rat)

L

11q13

USF, JunB

bZip

NF-kB, c-Myc, TNFa, IL1, RANKL, ET-1, LPS, b-glucan, Ct, HHV8, M-CSF, GnRH, AgII, gastrin, insulin, IKKs, LY294002, Epo., UVA

Fra2, FosL2 (human, mouse, chicken, fugu)

2p23-p22

bZip

FSH, IL15, TCR/CD3, PMA, IL5, bact., sIL6R, HHV8, estrogen

OASIS, BBF-2 (human)

11q11.2

NRF1, alpha-Pal  (human, mouse)

1

7q32

mediate

LPS, cantharidin

NF-E2 p45 (human, zebrafish)

E2

L

12q13

MafG, MafK

NF-kB, GATA1, IGF1, ARNT2

erythroid

Nrf1, TCF11, NFE2L1 (human, mouse)

L

17q21.3

MafG,

estrogen

Nrf2, NFE2L2 (human, mouse, rat,)

L

2q31

protect

MafG,

ATF4

TNF,IL1, progesterone

casp, O stress, targets

Nrf3, NFE2L3 (human, mouse)

1

7p15-p14

MafK

MVA

c-Maf (human, mouse, rat, zebrafish, fly, moskito)

L

16q22-q23

induce

NO, IL13

NK, T, kidney, lens

MafA (human, mouse, rat)

MafB, Kreisler, KRML (human, mouse, rat, chicken, frog), valentino (zebrafish)

1, kr

20q11.2-q13.1

APCs, NK

MafF (human, mouse, rat, chicken)

1

22q13.1

TNFa,  VEGF, Thrombin, hypoxia, HHV8, Ye

placenta

MafG (human, mouse, chicken)

MARE

L

17q25

NF-E2, NRF1, NRF2,

1

NRF2, MVA

MafK, NF-E2 p18  (human, mouse, rat, chicken)

L

7p22

Tprim

HLF (human)

17q22

bZip

brain

TEF (human)

22q13.2

THAD/PAR/bZIP

XBP1 (human, mosue, rat, frog, zebrafish)

X

L

22q12.1

IRE1, TIMP1

Bach1 (human, mouse)

1

21q22.11

NF-E2

BTB/bZip

Sp1

B

Bach2 (human, mouse)

1

6q15

promote

NF-E2

BTB/bZip

estrogen

B, T, fetal brain, class switching

NRL (human, mouse)

1

14q11.1-q11.2

retina

AIbZIP (human, mouse, rat)

1q21.2

androgen

HOX

Msx1 (human, mouse, rat, bovine,)

L

1

4p16.1

HOX

1

BMP4, IL13

Msx2, HOX8.2 (human, mouse, rat, dog, chicken, quail)

1,h

1

5q34-q35

induce

HOX

BMP4, NRF2, Foxc1, Pax3, Pg

PAX2 (human)

L

10q22.1-q24.3

inhibit

Egr1

kidney, targets

PAX3 (human)

cast

L

1

2q35

inhibit

PAX/HOX

1

Akt, FGF10

Pax5, BSAP (human)

L

9p13

Daxx

CD40

targets

Pax6 (human)

11p13

GR, Ct

PAX8, Aniridia (human)

L

2q12-q14

inhibit

TTF1

Pbx1, PRL (human)

1

1q23

erythroid

Pbx2, HOX12 (human)

6p21.3

hemato.

Pbx3 (human)

9q33-q34

PDX1, UF1, PDX1, IDX-1, MODY4, STF-1, IPF1 (human)

13q12.1

inhibit?/(-)?

HSV1

targets

TTF1, TITF1, BCH, BHC, T/EBP, NKX2A, TTF-1, NKX2.1 (human)

1

14q13

inhibit?

GATA6, PAX8, RARs, BR22, TAZ, NFATs, DREAM

Oct1, HNF3a, TSH, PKA, MST2

thyroid, lung

Csx, NKX2-5 (human)

L

5q34

regulate?

CAL,

heart

PMX1, PRX1, PRRX1 (human)

1q24

PMX2, PRX2, PRRX2 (human)

1

9q34.1

LPS

thyroid, lung, targets

PROX1 (human)

L

1q32.2-q32.3

RANTES

lymphatic endothelial cell

HOX3, HOXC8 (human)

12q13.3

targets

HOXD1, Hex4, Hox4G (human)

2q31.1

Brn3a

dorsal  ganglia, trigeminal

HoxD9 (human)

2q31.1

estrogen

HoxD10 (human)

2q31.1

targets

HoxD11, HOX4F (human)

2q31.1

ErbB4

Hoxa5 (human)

7p15-p14

induce

estrogen

adrenal, lung

Hoxa13 (human)

1

7p15-p14

(inhibit)

NOBOX, OG2 (human)

1

7q35

folliculogenesis

LHX1 (human)

17q12

LIMx2/HOX

RANKL

HLX, HB24, HLX1 (human)

1q41-q42.1

t-Bet

myeloid

IRX2, Iroquois 2 (human)

1

5p15.33

Brn3b

mammary grand

DLX1 (human)

2q32

Brn3b

brain

DLX2 (human)

2q32

Brn3b

brain

Pitx2 (human)

L

5q31

Pitx3 (human)

1, ak

10q25

SATB1 (human)

3p23

CUTx2/HOX

MIP3

T, NK, Thy, bm

CDX2 (human)

1

13q12.3

intestine, blastcyst, targets

TGIF (human)

18p11.3

TGFb, MIP3

CRX (human)

1

19q13.3

eye, targets

Hmx1, H6 (human)

4p16.1

Brn3a

Group	Name	Element	KO	gene	locus	Apoptosis	Binding Partners	Structure	3D	Upstream regulators	memo
Ets	Ets-1(human,mouse, rat, chicken, frog, zebrafish, Hr, moskito)	Ets1	L	1	11q23.3	inhibit/induce	proteins, Ubc9, DAXX	SAM/Ets	L	IL2, IL15, PEA3, Oct1, Oct2, Tprim, TNFa, RANKL, RA, Nef	T, NK, targets
	FLI-1, FLI1 (human), mouse,  rat, zebrafish, Xl, Ce, Dm)		1	1	11q24	inhibit		SAM/Ets	1	Ets1, AP1, Tprim,	NK, T, APCs
	PU.1, Spi1 (human), mouse, chicken)		L	1	11p11.2	induce	c-Jun, RNA, HDAC1	Ets/	1	PU.1, DMSO, IFNa, IFNb, IFNg, Notch1	preDC
	Spi-B (human, mouse, Xl, Re)	1	L		19q13.3-q13.4		CBP	no Ets homology			DC, B
	Spi-C (human, mouse, Re)				12q23.3
	Ets-2(human), mouse,  sheep, chicken, frog, sea urchin, fly)		1	1	21q22.3	inhibit/sensitize		SAM/Ets		LPS, IFNb, IFNg(-), AgII,O2 stress, Akt, Jnk, Wnt-1, CIITA, c-Myc, HHV8
	GABPa (human, mouse, rat, sheep)		1		21q21.3		GABPb, RYBP	SAM/Ets		RANKL, GM-CSF	hemato.
	GABPb, GABPB2, E4TF1, BABPB2, E4TF1B, GABPB1, NRF2B1, NRF2B2, E4TF1-47, E4TF1-53 (human)				15q21.2					GM-CSF
	ERG (human, mouse, rat, chicken, Dm)				21q22.3	inhibit		SAM/Ets		IL1a, GR
	ELK1 (human)		1		Xp11.2	induce		Ets/	1	MITF, GR, Rb2, AgII, GH, c-Myc,
	SAP1, ELK4 (human)				1q32			Ets/	L	ARNT2, MAPKs, irrad., AdV
	SAP2, ELK3 (human)				12q23			Ets/
	ER81, ETV1(human)		1		7p22			PEA3-N(MAPK-site)/Ets
	ETV3 (human)				1q21-q23
	ETV4 (human)				17q21
	ERM, ETV5(human)				3q28		TAFII60	PEA3-N/Ets		IL12, STAT4, PKA
	TEL1, ETV6 (human)		1		12p13	induce/ (inhibit)	H-L(3)MBT, N-CoR, Sin3A, SMRT, p38, IRF8	SAM/Ets		Sm, IGF1, CREB, STAT3, IFNa	CD34+, hematopoiesis, SUMO, ALL
	TEL2, TELb (human)				6p21			SAM/Ets
	ERF (human)				19q13			Ets/		D3
	PDEF, SPDEF (human)				6p21.3		AR	SAM/Ets
	FEV (human, mouse, rat)				2q36			Ets
	ELF1 (human)				13q13						hemato.
	ELF2 (human)				4q28			/Ets/
	ESX, ESE1, ELF3 (human)		1		1q32.2			SAM/Ets		NF-kB, IL1, TNFa
	ELFR, ELF4, MEF (human)				Xq26			Ets			hemato.
	ESE2, ELF5 (human)				11p13-p15			SAM/Ets
	EHF (human)				11p12			SAM/Ets		A2aR	epithelial
SANT	c-Myb (human)	Myb	L		6q22	(inhibit?)/(mediate?)	Mybs, PIASy, nucleolin	SANTx3	L	AP-1, p53, STATs, MZF1, GATA1, WT1, BCR, CD28, Tprim, IL2, CD3&IL2, IL-7, IL-15, IL1,C/EBPa, LPS,Nef, nicotine, Epo, cantharidin, OX-CA, estrogen, TIMP1	targets, SUMO, bm
	A-Myb, MYBL1 (human)		L		8q22	inhibit	Mybs, nucleolin	SANTx3		ER, RA	targets, T, NK
	B-Myb, MYBL2 (human)		1		20q13.1	inhibitt	CDK9, ZPR9, N-CoR, SMRT	SANTx3	1	Subst.P, LPS, St, YopM, c-Myc, N-Myc, B-Myb, AP1, ZPR9, ER, Rb2, ALK1, PTEN, CD3&IL2	targets, preB, bm
	hDMP1/DMP1/ DMTF(human)				7q21	(-)		SANTx3
	SNAP190, PTFa, SNAPC4 (human)				9q34.3		SNAPc subunits, Oct-1	SANTx5			PSE
	N-CoR, Ncor1(human)				17p11.2		Bcl6, COUP-TF1, HDAC3, HDAC4	cc/SANT/cc/SANT
	SMRT (human)				12q24		PLZF, Bcl6, T3Rs, RARalpha, COUP-TF1, STAT5, B-Myb, HDAC3, HDAC4,CBF1, TBL1, TEL	cc/SANT/cc/SANT		MEK1,CKII

Group	Name	Element	KO	gene	locus	Apoptosis	Binding Partners	Structure	3D	Upstream regulators	memo
RFX	RFX1 (human)				19p13.1				1	PMA
	RFX2 (human)				19p13.3-p13.2					GnRH
	RFX3 (human)		1		9pter-9q22.33
	RFX4 (human)				12q24
	RFX5 (human)		BLS, 1		1q21		RFXANK,RFXAP, CIITA	RFX/AT hook		TNFa, IFNg, dsRNA	hemato.
	RFXANK (human)		BLS		19p12		RFX, CIITA	ANKx4
	ANKRA (human)				5q12-q13		Megalin
	RFXAP (human)		BLS		13q14		RFX, CIITA
SAP	MKL1, MAL, BSAC (human, mouse)				22q13	inhibit		RPELs/SAP/cc
	CARP1, DIS, FLJ10839 (human)				10q22.1	inhibit	14-3-3, IKKg	SAP/cc		CD437, adereamycin
	DBC1 (human)				8p22		IKKb	SAP/cc			brain
TBX	TBX1 (human)	T box	DGS, 1		22q11.21					PS1, Shh, CREB, Foxa2, Foxc1, Foxc2
	TBX2 (human)				17q23					MITF, c-Myb, B-Myb, BMP2
	TBX4 (human)		1		17q21-q22
	t-Bet, TBX21 (human)		L		17q21.2		Hlx			JunD,IFNg, IL15, IL21, IL30, PPARa, CpG/TLR9,  Ec, Hp,	NK
	TBX3 (human)		1		12q24.1	inhibit			1		adrenal
	TBX5 (human)		1		12q24.1	induced
	TBX6 (human)				16p11.2
	TBX10 (human)				11q13.1-q13.2
	TBX18 (human)		1		6q14-q15
	T, Brachyury, TFT (human)				6q27					Wnt3a	preB
	TBX19, TPIT (human)		ACTHd		1q23-q24						pituitary
	TBX20 (human)				7p15-p14
	TBX22 (human)				Xq21.1
	T-brain-1, TBR1 (human)				2q24						brain
	Eomesodermin, T-brain-2, TBR2, EOMES (human)		1		3p21.3-p21.2						blastcysts
CP2	CP2, UBP1, LBP1a (human)		1		3p23						hemato, maternal, extraembryonic angiogenesis

Group	Name	Element	KO	gene	locus	Apoptosis	Binding Partners	Structure	3D	Upstream regulators	memo
IRF	IRF1 (human, mouse, sheep, bovine, chicken, fugu)	IRE	L	1	5q31.1	induce/inhibit	p300	IRF	1	IFNa,b, IFNg, IL1b/IFNg, IL1, IL1b, IL12, TNFa, IL2, TRAIL, AgII, virus, dsRNA, Subst.P, LPS, MDP, LTA, Cp, Hi, Ma, St, Sd, Pa,  Tc, Tg, flagellin, hsp65, dsDNA, dsRNA, MCMV, HHV8, Nef, TRIF, TRAF2/TRAF5, FANCC,PMA, M-CSF, RA, androgen, IL10, HIVEP1	hemato.
	IRF2 (human, mouse, sheep, chicken)	IRE2	L		4q35.1			IRF	L	IFNa, IFNb, IFNg(-), TRAIL, SCF, c-Myc, LPS, MDP, Ct, Tc, EV71, Nef, CsA, PI3K, PMA,	PBL
	IRF3 (human, mouse, chicken, frog)		L	1	19q13.3-q13.4	mediate	TRIF	IRF		viruses, c-Myc, Ld, Mt, Tg, Nef, Notch, SDF1, DNA-PK	hemato., targets, NS3/4A
	IRF4 (human, mouse)		L		6p25-p23	mediate		IRF		IL2, IL12, LPS, PMA, BCR,  Blimp1, CsA/FK506	preB, B, targets
	IRF5 (human, mouse)				7q32		IRF7	IRF		TNFa, , AgII, ribavirin, HIV Vpr	preB, B, myeloid
	IRF6 (human, mouse, sheep, frog)		VWS		1q32.3-q41			IRF		SDF1,
	IRF7 (human A, B, C, C.2, H, mouse)		1	1	11p15.5		ORF45, IRF5, p300	IRF		NF-kB, ISGF3, CREB, IFNa/b, IFNg, LPS, LTA,  CpG, Bm, Hp, Lm, Mt, Tg, IFNb, BRCA1, IL1b/IFNg, TNFa, PMA, M-CSF, dsRNA, viruses: HCV., MV, HHV8, HIV Vpr, ribavirin, TRIF, SOCS1	DC
	IRF8, ICSBP1 (human, mouse, rat)		L		16q24.1		TEL			Miz1, AIRE, IL12,  LPS, hsp65, Tc, HHV8, Lyn	DC
	IRF9, ISG3gamma, ISGF3G, p48, ISGF3 (human, mouse,rat,chicken)		1		14q11.2	mediate?		IRF		IFNa,b,g, LPS, Hp, hsp65, HHV8	hemato.
MADS	SRF (human)	SRE	1		6p12.3	inhibit			L	Tec, IL8	casp
	MEF2A (human)		1		15q26	inhibit	Dermo1,HDAC5		L	Ca, HDAC4, EV71, TIMP1	casp
	MEF2C (human)		1		5q14		CARM1, GRIP1			SCF, camptothecin, CREB, KCl	brain, preB, sumo
	MEF2D (human)				1q12-q23						casp, sumo
POU	Oct1, POU2F1 (human)	Oct	L		1q22-q23		MAT1	POU	L	PPARa, UVA
	Pit1, GHF1, CPHD, POU1F1(human)		1, dw		3p11						pituitary
	Oct2, OTF2, POU2F2 (human)		L		19q13.31		MAT1	POU	1	LPS, CD86, b2AR
	Oct6, POU3F1 (human)				1p34.1
	POU3F2, BRN2, OCT7, OTF7, POUF3 (human)				6q16					P2Y2
	BRN1, POU3F3 (human)		1		2q12.1					Pax2
	BRN3a, Brn-3.0, POU4F1 (human)		1		13q21.1-q22	inhibit				CREB, Brn3b	targets
	BRN3b, BRN3.2, POU4F2(human)		L		4q31.2	inhibit					targets
	BRN3c, POU4F3 (human)		L		5q31	inhibit
	FLJ25680 (human)				5q22.1
	OTF3, OTF4, POU5F1, Oct3, Oct4 (human)		1		6p21.31		MAT1	POU	1	hypoxia, Sp1, Sp3, ARNT2
	Oct11, PLA1, Epoc1, Skn-1a, POU2F3 (human)				11q23.3
	BRN5, MPAU, TCFB1, POU6F1 (human)				12					P2Y2	(brain)
HSF	HSF1(human)	HSEx3	L		8q24.3	(inhibit)	DAXX	HSF	l	Tprim, Fas, LPS,
	HSF2 (human)		L		6q22.33	(inhibit)		HSF		AgII, Subst.P, LPS
	HSF4 (human)				16q21			HSF
	LW-1 (human)				Xq28			HSF
	HSFY, HSF2L (human)				Yq11.222			HSF
	LOC162297 (human)				17q23.3			HSF
STAT	see STATs
Other	Che-1, RNA pol II sub 11, traube, AATF, DED (human, mouse,rat)				17q11.2-q12	inhibit	DLK, Rb, TSG101, Par4	acidic		camptothecin	HDAC1 competitor
	NMI (human)				2p24.3-q21.3		N-Myc, STAT5b	CC/RRM		IFNa/b, IL2, Ets1	hemato.
Runt	AML1, Runx1, Cbfa2, , PEBP2AB (human, mouse, rat), zebfrafish), Dm, RNT1(Ce)	1	L		21q22.3				1	Brn3a
	Cbfa1, Runx2, AML3, PEBP2a, OSF2 (human, mouse, rat, zebrafish,		L		6p21	inhibit?	STAT1, PEBP2B			BMP2, BMP7, Dlx5, Nur77
	Runx3, AML2, Cbfa3, PEBP2aC (human, mouse, rat,		L		1p36
NF-Y	NF-Y alpha, NFYA (human)	CCAAT			6p21.3					Ma, GM-CSF
	NF-Y beta, NFYB (human)				12q22-q23		CIITA			MTF1
	NF-Y gamma, NFYC (human)				1p32		CIITA			DIM, I3C
AP-2	AP-2 alpha, TFAP2A (human, mouse, sheep, zebrafish)		L		6p24	induce				AIRE	placenta
	AP-2 beta, TFAP2B (human, mouse)		1		6p21-p12					Brn3a, EV71
	AP-2 gamma, ERF1, TFAP2C (human, mouse, rat)		1		20q13.2					UVB	placenta
	AP-2 delta (mouse)
	AP-2 epsiron, AP2E (human, mouse)				1p34.3