Index Caspase CARD/DED/BIR Bcl-2  DD TNF/TNFR Kinases ILs Viral Lipid Engulf TF RING Toll Other Apop Other NFkB Alphabet

Transcription Factors
 

family name
apoptosis
 Binding partner locus gene KO Structure Upstream regulators 3D memo
Rel/IkB RelA/p65(human,mouse), rat, chgicken, Xl)
inhibit
 NFkBs, TFIIB, TLS, TAFII105, hsp70, PP2A, HDAC1, CBP, SIRT1, Egr1, Sp1,  PIAS3, FAF1 11q12-q13 1 L Rel/AD TNFa, IL1, GM-CSF, LPS, ER stress, IFNg, Lm, Subst.P, UV, irrad, M-CSF, TCDD, Akt, PKG, nicotine, D3 p65/p50/IkBa(1, 2) casp3

RelB/I-Rel(human, mouse, chicken)
inhibit
 NFkBs 19q13.1-13.3 1 L Rel/AD NF-kB, IL1, TNFa, RANKL, PMA, LPS, hsp65, Lm,  Ld, Mt, Tg, Ye, D3, TIMP1
B

c-Rel(human, mouse)
inhibit
 NFkBs 2p13-p12 1 L Rel/AD NF-kB, TRAIL, IL1, LPS, Bm, Ld, Lm, Mt, Tg, sBLP, S.t., PU.1, (p38), PKA


NFkB1/KBF1/EBP1/p105 (human, mouse, chicken), p50
inhibit
 NFkBs, p300, p202, JLP, Clarp, STAT3, ABIN2
 4q23-q24 1 L Rel/ANK/DD NF-kB, PMA, TNFa, RANKL, IFNa, IL1, TRAIL, IL2, CD3/CD28, Subst.P, LPS, PGN, BLP, CpG,  LTA, dsRNA, hsp65, CSBG, Hi, Ld, Lm, LLO, Ma, Mt, St, Tg, Ye, flagellin, DEX, PDX1, Rac2, AmB, PKG, phenytoin, camptothecin p65/p50/IkBa(1, 2)

NFkB2/KBF2/Lyt-10/H2TF1/p100(human, mouse, chicken, Xl), KBF3/p49(human), p52
induce
 NFkBs, S9 10q24 1 L Rel/ANK/DD NF-kB, TNFa, IL1, GM-CSF, M-CSF, RANKL, LPS, MDP, LTA, CSBG, Hi, Ma, Ld, Lm, Mt, St, Tg, Ye, HHV8, MVA, flagellin, AP1, PMA, HOX11, Lyn,  UVB, Nef, CsA.,MV, PKG, UVA, (p52)x2/DNA (preB)

Dorsal(D.m.),  Dorsal B
Relish, Dif, Tube 2L 1 1 Rel/AD NF-kB, TNFa, PMA


DIF (D.m.)
Relish, Dorsal 2L 1 1 Rel/ANK



Relish (D.m.)
Dif, Dorsal 3R 1 1 Rel/ANK



IkBa, MAD3, NFKBIA (human, mouse,rat,pig)
induce
 NFkBs, p53 14q13 1,m L P/ANK/PEST NF-kB, c-Myb, B-Myb, Egr1, CBF1, TNFa, TRAIL, Fas, CD40, RANKL, CD8/28, CD43, IL1, IFNg, LPS, PGN, KF1B, MDP, LTA, sBLP, dsRNA, Ld, Lm, LLO, Mt, Pa, Pg, St, Tg, Ye, flagellin, PMA, DEX, CpG, HHV8, CSV-B3, irrad, Cannabinoid, NIK, CsA/FK506, HHT, YopP, c-Abl, ER, estrogen p65/p50/IkBa(1, 2) casp8,
(APCs, B, T, NK)

IkBb (human,mouse)
NFkBs, MCC1 19q13.1 1 1 P/ANK LPS, Lm, St, IFNg, RANKL, IL10, IL5


IkBe, NFKBIE (human)
NFkBs,  6p11.2-21.1 1 1 P/ANK/PEST IL1, TNFa, PMA, CD3, LPS, flagellin, St, MVA, irrad


Bcl-3(human)
inhibit
 NFkBs, B3BP, Jab1, Tip60, Bard1 19q13 1 L Ank NF-kB, STAT3, c-Myc, p53, TNFa, IL1, IL6, IL10, IL12, GM-CSF, SDF1, M-CSF, LPS, Tg, HHV8, g-irrad., MV, NcoRi, camptothecin L

MAIL, INAP, IkBzeta (human, mouse)
inhibit
 p50(-) 3p12-q12
1
 Ank PPARg, LPS, IL1, BLP, PGN, KF1B, MALP, R848, CpG, Flagellin, TNFa, Lm
(APCs, B, T, NK) IL6

Cactus(D.m.)
Dorsal, Tube 2L 1 1 Ank/PEST



IKB-1(C.e.)


1




v-Rel v-Rel(REV)








vIkB A238L(ASFV)
calcineurin, RelA
1 1 Ank


NF-AT NF-ATC1 (human, mouse, pig)
(mediate)
 RACK1 18q23 1 L Rel TCR/CD3/28, RANKL, Ma, GM-CSF, MHC, Calcineurin, Pim-1, Bcl-2, Nef, CsA, IL1b/TNFa, DEX, NFATp, IGF1 1 IL2,IL4

NFATp/NF-ATC2(human) (inhibit)/(induce) AP-1 20q13.2-q13.3 1 L Rel Calcineurin, RANKL, ARNT2
IL2,FasL

NF-ATC3, NFATx  (human, mouse) inhibit
16q13-q24 1 1
 Rel Yp, GR, MVA


NF-ATC4 (human, mouse) (inhibit)/(induce)
14
1 Rel L-CaCh, GSK-3, PMA, LPS
FasL

NF-AT5/TONEBP(human, mouse)

16q22.1 1 1 Rel


target element: GGGRNYYYCC
 

On-line Review

Review issue of NF-kB in Oncogene (1999)
NF-kB activation by Ghosh S, May MJ, Kopp EB (Annu Rev Immunol 1998), Baeuerle & Baltimore (Cell 1996), Richmond (Nat Rev Immunol 2002), Li & Verma (Nat Rev Immunol 2002)
proteasome by DeMartino GN, Slaughter CA (J. Biol. Chem. 1999)
PPARg by Willson et al. (Annu Rev Biochem 2001)
Transcriptional regulation during B cell development by Henderson & Calame (Annu Rev Immunol 1998)
Transriptional Coactivator by Tjian et al. (Annu. Rev. Biochem. 2001)
Links
Rel/NF-kB Transcription Factor Web Site by Gilmore T.D. (Boston Univ)


Other Transcriptional Apoptosis Regulators
(See NFkB and Apoptosis Regulators, Kinases, too)
 
 
Group Name Element KO gene locus Apoptosis Binding Partners Structure 3D Upstream regulators memo
Ces ces-1(C.elegans, C.b.)
1 1
inhibit
ZnF(Snail)



ces-2(C.elegans)
1 1
induce
bZIP(PAR)



ces-3(C.elegans)
1







Zn SLUG(human, mouse), SNAI2,  SNAIL(D.m.)

1 8q11
inhibit
ZnF
PAX3-FKHR, MyoD, BMP2, HHV8 epithelial, adipocyte etc

SNAI1 (human)


20q13.1



AdV

Requiem, REQ (human, mouse), d4

1 11q13
inhibit
ZnF
D3

RYBP, DEDAF, YY1AF2, YAF2 (human, mouse)

1 3
Casp8, Casp10, FADD, E2Fs, YY1 RING
Ma, ribavirin

zf3, ZNF319 (human, mouse)


16q13
induce
ZnFx15



PAG-3 (C.e.),  Gfi1 (human, rat) IP L 1 1p22
inhibit
SNAG/ZnFx7
BRN3C

Egr1, Krox24, Zif268 (human, mouse)
L 1 5q31.1
mediate/inhibit
 RelA
L CREB, AP1, WT1, Egr1, ARNT2,  FKHR, Akt, PKCb, hypoxia, irrad., BRCA1, Ct, Ec, Ld, Sa, St, Tg, RSV, TNFa, TRAIL, RANKL, LPS, IFNg, IL5, CXCL9, IL1, GM-CSF, GnRH, VEGF, HPV11, FVIIa, IgM, TCR/CD3,  Notch, endostatin, fumagillin, insulin, IGF1, UV, ER stress, NO, O stress, GH, AgII, ET-1, PGE2, PMA, CsA, ethanol, heat shock, hypoxia, ER, PDX1, BMP2, Blimp1, OX-CA, KCl
 targets

Egr2, KROX20 (human)
1 1 10q21.1-q22.1
induce
ZnF
NF-AT, IL5, Fas, TCR/CD3, GnRH, VEGF, insulin, Lm, Tg, PTEN, estrogen, Rac2, D3

ZNF365 (human)


10q21.2



TNFa brain

Egr3 (human)
L 1 8p23-p21
enhance
ZnF
NF-AT, c-Myc, IL5, IL8, VEGF,  Thrombin, estrogen, HHV8 brain

Egr4, NGFI-C (human) GSG 1
2p13



NGF, CREB

Sp1 ( human) cast

12q13.1
regulate

L
casp

Sp3 (human)







phenytoin

FKLF2, RFLAT1, KLF13 (human)


15q12
CBP/p300, PCAF


Erthroid, NK, APCs, B, T,

TIEG (human)


8q22.2
induce
ZnFx3
TGFb, GR, TNFa, Wnt3a, HHT

WT1 (human)
L
11p13
inhibit/induce
 Ciao1

HOX11, c-Myc, PEA3, AP1, HNF4a, LIF, HBx, Vasopressin, RA targets

Zac1, Zac, Lot1, PLAGL1 (human)


6q24-q25
induce
ZnFx5



Ikaros, IK1, Lyf1, ZNFN1A1 (human)
1
7p13-p11.1
regulate
ZnFx6
Tprim, LPS, VDR, IL5
 hemato.

H-plk (human)


7q11.21

ZnFx10
HCV core

ZNF92, TF12, HPF12 (human)


7q11.21



CSBG hemato.

ZNF148, ZBP89 (human)


3q21
induce


FSH
 hemato.

ZNF24, KROX17 (human)


18q12



Ct lymphocytes

ZNF35, HF.10 (human)


3p22-p21



GR, insulin, IGF-II, UVB

ZNF36 (human)


7q21.3-q22.1



RANKL, IL2, estrogen, GR, CREB, IGFBP2, HHV8

ERF1,  ZFP36L1, BRF1, cMG1, ERF-1, Berg36, TIS11B, RNF162B (human)


14q22-q24
Sim1

PMA, EGF, IL4, ARNT2

ZNF76 (human)


6p21.3-p21.2

ZnFx7

Sumo

ZNF165, LD65 (human)


6p21.3

ZnFx5
IL8 testis

WIZ (human)


19p13.1

ZnFx11
LPS

LKLF, KLF2 (human)


19p13.1



TRAF2, PDGF B, T, NK, APCs

ZK1, ZNF443 (human)


19p13.2
enhance



preB

ZNF43, HTF6 (human)


19p13.1-p12



AmB

ZNF85 (human)


19p13.1-p12






ZNF160, F11, HZF5, KR18, HKr18 (human)


19q13.3-q13.4

KRAB/ZnFx20
MeDNA

ZNF91, HPF7, HTF10 (human)


19p13.1-p12

KRAB/ZnFx32
Ma, RA, GM-CSF, IGFBP2 brain, hemato.

ZNF93, TF34, HPF34, HTF34 (human)


19p13.1-p12



ARNT2

ZNF146, OZF (human)


19q13.1



c-Myc, progesterone hemato.

EKLF, KLF1 (human)


19p13.13-p13.12



Subst.P, LPS, GATA1, IL5
 erythroid, endothelial

ZNF382 (human)


19q13.13



Cdx2

MZF1, ZNF42 (human)


19q13.2-q13.4



RA, EV71

ZNF124, ZK7 (human)


1q44
inhibit


VEGF erythroid

ZNF125, HZF3 (human)


11q23.1-q23.2



FSH, b-catenin

ZNF128 (human)


11q23.1-q23.2
TIF1beta




PLZF, ZNF145 (human)
L
11q23.1
inhibit



lung, targets

ZNF131 (human)


5p12-p11

ZnFx6
TNFa, Ct hemato.

ZNF132 (human)


19q13.4



IGFBP2

ZNF133 (human)


20p11.23-20p11.22



HHV8

ZNF134 (human)


19q13.4



IGFBP2 lymphocytes

ZNF137 (human)


19q13.4



estrogen

ZNF350, ZFQR, ZBRK1 (human)


19q13.41
BRCA1

DNA-damaging reagents

ZNF143, SBF (human) SPH

11p15.4
regulate?





ZNF177 (human)


19p13.2



endostatin, fumagillin

ZNF207 (human)


17q11.2

ZnFx2
SCF

ZNF208 (human)


19p12






ZNF408 (human)


18q23




bm