Index Caspase CARD/DED/BIR Bcl-2  DD TNF/TNFR Kinases ILs Viral Lipid Engulf TF RING Toll Other Apop Other NFkB Alphabet

Death Domain (DD) containing proteins
 
group name apoptosis NF-kB activation interacting protein KO gene Locus Ligand 3D regulators
DD-receptor see Death Receptors of TNFR family








Mediator FADD (see DED proteins)









RAIDD (see CARD proteins)









BG4(D.m.)









TRADD (human, mouse, zebrafish) induce induce TNFRI, p75NTR, TRAF2,RIP,FADD, TRAF2, Stat1, keratin 8/18, HIPK2, Akt 1 1 16q22
N/TRAF2,N PTEN, CD3, UVC, PG-A2, heat shock, Hi, Ld, Lm, Mt, Tg, RA

unknown, 9130005N23Rik (mouse)









MYD88 & Tube  (see Innate Immunity)









PLAIDD, NRADD (rat, mouse) induce



*

PS-I

Imd, BG5(D.m.) induce induce dFADD 1




kinase RIP, DAP kiasen, IRAK family (see kinases or Toll-associated)








other Ankyrin, Unc-44

Band 4.2, NaKATPase,GP85,Fodrin etc






Unc5(C.e.), human (a,b,c), Rcm(mouse), rat(h1, h2) induce
Netrins, NRAGE 1,2 1 4q21-q23

p53, KCl

ZUD (human, rat) enhance inhibit NF-kBs

6p21.1



p84N5(human, mouse, Dm, Ce, Ag, At, Dd), Sp) induce induce Rb
1 18p11.32



LRDD/Pidd(human,mouse) induce
FADD/MADD, RAIDD

11

p53

MALT1 (see caspases & related proteins)









DD2(sponge)









for NF-kB, click here








Incorrectly Reported MADD








Review of Death Recptors by Ashkenazi & Dixit (Science 1998)

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. by Holler et al. (Nat Immunol 2000)


Copyright by Naohiro Inohara, Department of Pathology, University of of Michigan Medical School
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