Index Caspase CARD/DED/BIR Bcl-2  DD TNF/TNFR Kinases ILs Viral Lipid Engulf TF RING Toll Other Apop Other NFkB Alphabet
class name
apoptosis
NFkB activation
 JNK/p38 activation
 Binding partner Structure 3D KO gene locus upstream regulators expression
 signals memo
Cell Cycle CDK1, CDC2 (human)
induce/(-)/suppress

cyclins A, B, B, GADD45, Ded1, Myt1, Bcl2, Pin1, kinase


10q21.1 p53, NF-Y, GATA1, Mad1, PLZF, TGFb1, Fas, IL10/12, insulin, LPS, Hp, Sm, PKR, RA, RXR-gamma, 5FU bone marrow, preB, endothelial
casp

CDK2 (human)
mediate

cyclins A, E, p21, Waf, C/EBPa, 
L L
12q13 RA, Sp1, IRF1, RXR-gamma, IL15, 5FU bone marrow, preB, endothelial
casp

CDK4, PSK-J3 (human)
induce

cyclin D, INK4s, p21, p27, p57, survivin, Waf, C/EBPa,

L
12q14 sIL6R, CD40, Ld, cantharidin bone marrow, preB, endothelial AP1

CDK5, PSSALRE (human)
induce/inhibit
inhibit
 cyclin E, nck5a, NF-M, dbpA,
1 L
7q36 CD40, Ld, UVB, Epo, IL5
 brain
 TPKII, c-Abl, SET calpain

CDK6, PLSTIRE (human)


cyclin D, v-cyclin, INK4s 
L

7q21-q22 Sp1, HIV Vpr ubiquitous
  

CDK7, STK1, MO15, CAK1 (human)


cyclin H,  MAT1,



5q12.1 RANKL epithelial, preB


CDK8 (human)


Cyclin C, E1A, VP16



13q12 FSH, RA bone marrow, preB, endothelial TFIIH

CDK9 (human)
inhibit/ enhance

cyclins T, K, Rb, B-Myb, TRAF2



9q34.1 cisplatin, UVA hemato.
 TFIIH Ub

PISSLRE, CDK10 (human)







16q24
hemato.


CDK11 (human)




1

6q22.1
ubiquitous


PITSLRE A, CDC2L2 (human)
mediate

cyclin D3, TFIIS, TFIIF, ELL2, FACT, PAK1



1p36.3
hemato.
casp

PITSLRE B, p58, CDC2L1 (human)







1p36.3
hemato.


PCTAIRE1, PCTK1 (human)


14-3-3s



Xp11.3-p11.23 RANKL ubiquitous


PCTAIRE2,  PCTK2 (human)







12q22 IFNa/b ubiquitous


PCTAIRE3,  PCTK3 (human)







1q31-q32
spinal cord, brain


PFTK1 (human)







7q21-q22
ubiquitous


ALS2CR7 (human)







2q33.2
ubiquitous


CDKL2 (human)







4q21.1
ubiquitous


NKIATRE, CDKL3 (human)







5q31
ubiquitous


CCRK, CDCH (human)







9q22.1
ubiquitous



CHED, CDC2L5 (human)







7p13
ubiquitous



CLK2 (human)







1p31 HCV hemato.


Wee1 (human)







11p15.3-p15.1  IGF1 bone marrow, preB, endothelial


CRK7 (human)







17q21.2
ubiquitous


CHK CHK1, CHEK1 (human)
inhibit

ATR, Ded1

1
11q24-q24 p53, LPS, Hi, estrogen
 bone marrow, preB, endothelial DNA damage

CHK2, RAD53, CHEK2 (human)
mediate




1
22q12.1 p53; ATM
 ubiquitous
 DNA damage
MAK MAK (human)







6q22
PBL


ICK (human)







6p12.3-p11.2
ubiquitous


Warts LATS1 , Warts, Kpm (human, Dm)
induce

Zyxin, CDC2,  UBA/kinase
1
6q24-q25.1
ubiquitous




LATS2, kpm (human)



UBA/kinase


13q11-q12
ubiquitous

Polo PLK, PLK1, STPK13 (human)
regulate

PLKK1



16p12.2 Rb2, estrogen, progesterone
 bone marrow, preB, endothelial


SNK, Plk2 (human, mouse)
induce



1
5q12.1-q13.2 serum, p53, p73,  IL1, estrogen, MIP3, ribavirin, Lm,Ye, AdV
 smooth muscle, cardiac, brain


Prk, Fnk, Plk3, CNK (human)
induce






1p34.1 IL3, TPO, DNA damage, irrad, UVA, ATM hemato.

DYRK MNBH, DYRK1A (human), Minibrain (Dm)





1
21q22.13 IL8 hemato.


MIRK, DYRK1B (human)







19q12-13.1
ubiquitous


DYRK2 (human)







12q14.2
hemato.


DYRK3 (human)







1q32
ubiquitous


DYRK4 (human)







12p13.32 Sp, irrad ubiquitous

PRP4K
 PRPF4B, PRP4K (human)



?/kinase


6p25.2
 FSH ubiquitous, highest in hemato.

class name
apoptosis
NFkB
 JNK/p38 Binding partner Structure 3D KO gene locus upstream regulators expression
 signals memo
MAP4K MAP4K1, HPK1(human, mouse)
enhance
activate
 activate Crks, Grb2, BLNK, SLP76, HS1, GRAP2, EGFR kinase/CNH

1 19q13.1-q13.4 IL5 APCs, B, T, NK
 TCR/BCR, Epo, Syk to MEKK1, casp3

MAP4K2, RAB8IP, GCK (human, mouse, rat, fly, C.e.)
sensitize/inhibit
activate
 activate MEKK1, TRAF2, Rab8 kinase/CNH

1 11q13 Wnt3a B


MAP4K3/GLK/RAB8IPL1(human, mouse)

activate
kinase/CNH

1 1p34.1-p32
ubiquitous IL10/LPS

MAP4K4, NIK, HGK(human, mouse)

activate NCK, MEKK1, GBP3, RasGAP, p65DOK, b1 integrin, kinase/CNH

1 2q11.2-q12 Rb2, Fas, camptothecin ubiquitous


MAP4K5, KHS, GCKR (human, mouse)
(-)
 activate Crks, TRAF2 kinase/CNH

1 14q11.2-q21 methamphetamine ubiquitous


NRK(human partial, mouse)



kinase/CNH

1,2 Xq22
ubiquitous


MINK, misshapen (human 1, 2, mouse 1,2)


Dock kinase/cc/CNH

1 17p13.2
ubiquitous


DMPK (human)


MKBP, Raf1



19q13.3
heart


MRCKbeta, DMPK-like CDC42BPB (human)


CDC42 kinase/cc/C1/PH/CNH/PHD


14q32.3
ubiquitous (highest in brain)


CDC42BPA, PK428 (human)


CDC42, GM-CSF Ra



1q42.11
brain, spinal cord


MASK, MST4 (human)


CDC25a, Raf kinase/cc

1 Xq25-26.3 estrogen NK, B, T, APCs


Citron kinase, CRIK, STK21 (human)
inhibit

Rho kinase/CNH
1
12q24.1-q24.3 Ret
 ubiquitous (highest in brain)


MIG-15(C.e.)

require
kinase/CNH

1




Ste20 PAK1(human, mouse, rat), frog, dPAK1(fly), C.e., Ste20(Sc, Sp)
protect
activate
 activate/(-) Cdc42, Rac1,  Nck, Tak1, PI3K, Hgs, PITSLRE PBD/kinase 1
1 11q13-q14 TGFb ubiquitous CXCL1, Fas, casp3, PDK1, Rac, Cdc42, CDK5 p. Bad,
casp3

PAK2 (human, rabbit, rat)
affect morph.?
activate Cdc42, Rac1, Pixb PBD/kinase

1 3q29 TGFb, FSH, Hp, Fas, camptothecin, progesterone
 ubiquitous
casp

PAK3 (human, mouse, rat)

activate Cdc42, Rac1, Pixb, Tax PBD/kinase

1 Xq21.3-q24 AP-1 ubiquitous
casp

PAK4 (human)
inhibit
weak act. Cdc42, LIMK1, KGFR PBD/kinase
1 1 19q13.13
ubiquitous


PAK6, PAK5(human)
inhibit

Cdc42, Rac PBD/kinase
1 1 15q14 RANTES brain


PAK7, PAK5(human)  
activate
PBD/kinase


20p12
brain


SOK1, YSK1, STK25 (human, mouse)

(-)
PBD/kinase

1 2q37.3 SCF ubiquitous stress

OSR1 (human)


KCC3, NKCC1, NKCC2 kinase/RD

1 3p22-p21.3 
ubiquitous


SPAK, DCHT, STK39 (human)
(-)
activate
 KCC3, NKCC1, NKCC2, PKCtheta TM?/kinase/RD

1 2q31.1 androgen ubiquitous (highest in brain)


STK36 (human), Fused, FU (Dm)



kinase/?/HEAT


2q35
ubiquitous GLI2

STK2, NRK2, NEK4 (human)



kinase/PX


3p21.1 HBV ubiquitous TTF1, TNFa, LPS, Sm

STK3, MST2, Krs1(human) inhibit
(-)
kinase


8q22.2 IL1 ubiquitous stress,

STK24, STK3, MST3(human)



kinase

1 13q31.2-q32.3 IL1, RA ubiquitous


STK4, MST1, Krs2(human), Hippo (Dm)
induce

DAP4, MST1 kinase

1 20q12-13.2 LPS hemato.
 MT-21 casp, Ub

STK6, AIP (human)







20q13.2-q13.3 LPS, ALA, NO bone marrow, preB, endothelial, testis


STK9, CDKL5 (human)







Xp22
ubiquitous


Aurora kinase A, STK15, ARK1, AURKA (human)



kinase


20q13 E2F1, Rb2, ER, estrogen



Aurora kinase B, STK12, STK5/mSTK1, ARK2, AIM1 (human,mouse)



kinase


17p13.1 FKHR, ER, estrogen preB


STK22B (human)



kinase


22q11.21 ARNT2 ubiquitous


STK22C, STK22D (human)



kinase


1p35-p34
ubiquitous


SSTK (human)



kinase
1
19p13.11
testis


STK18, SAK, PLK4 (human)



kinase/RD


4q27-q28
bone marrow, preB, endothelial


SLK, SMAK, STK2 (human, mouse)
promote
activate
kinase/RD

1 10q24.32
ubiquitous
casp

STK25, SOK1, YSK1(human)



kinase/RD

1 2q37.3
ubiquitous


ILPIPA, CALS-21, PRO1038, ALS2CR2 (human)
inhibit
enhance XIAP kinase


2q33-q34
erythroid, loocyte


LYK5 (human)



kinase


17q24.2
ubiquitous


STK10, Plkk1, LOK (human, mouse, frog)

(-) Plk1 kinase/RD


5q35.1 GR NK, B, T, APCs
polo-KK

JIK, KDS(human, mouse)

inhibit
kinase/RD


12q
NK, B, T, APCs EGF

TAO1(human, rat)

activate
kinase/RD


16
ubiquitous


TAO2, PSK (human, rat)

activate
 MEK3,6 kinase/RD


16p12.1
ubiquitous
MEKK

NEK1 (human)







4q32.3
ubiquitous


NEK2 (human)



kinase/cc


1q32.2-q41 AIRE
 bone marrow, preB, endothelial, testis


NEK3 (human)







13q14.13 CSBG ubiquitous


NEK6 (human)
inhibit?
 induce





9q33.3-q34.11
ubiquitous


NEK7 (human)







1q31.3
ubiquitous (heighest in blood cells)


NEK9, NERCC (human)







14q24.2
ubiquitous (heighest in blood cells)


NEK11 (human)







3q22.1
ubiquitous

casein kinase
 CK-I alpha, CSNK1A1 (human)
 inhibit






5q32
ubiquitous (highest in epithelial)


CSNK1A1L (human)







13q13.2




CK-I gamma1, CSNK1G1 (human)







15q22.1-q22.31
ubiquitous


CK-I gamma2, CSNK1G2 (human)







19p13.3
ubiquitous (heighest in blood cells)


CK-I gamma3, CSNK1G3  (human)







5q23
B, NK, epithelial, APCs


CK-I delta, CSNK1D (human)







17q25
B, NK, epithelial, APCs


CK-I epsilon, CSNK1E (human)







22q13.1
ubiquitous


LOC149420 (human)







1p35.3




VRK1 (human)







14q32
 estrogen bone marrow, preB


VRK2 (human)







2p16-p15
bone marrow, preB, endothelial


VRK3 (human)







19q13
testis, B, T


TTBK2 (human)







15q14
ubiquitous

class name
apoptosis
NFkB
 JNK/p38 Binding partner Structure 3D KO gene locus upstream regulators expression
 signals memo
ILK ILK (human)
inhibit

CD29 Ankx3/kinase
L
11p15.5-p15.4 PPARb, DAB2, PDX1
 ubiquitous


LOC51086 (human)



cc/Ankx6/kinase


1p31.1
ubiquitous

TLK TLK1 (human)


ASF1 cc/cc/kinase


2q31.1
ubiquitous (highest in hemato.)
 chromatin assembly

TLK2, PKUa (human, mouse)







17q23 IFNa/b ubiquitous

GSK3 GSK3alpha, GSK3A (human)
enhance






19q13.31 ILK ubiquitous Akt, insulin

GSK3beta (human)
mediate/inhibit
mediate
AKAP220, axin, MEKK1
w/axin L
3q13.3 Rb2, c-Myc ubiquitous b-catenin, CDC42, Notch, Fas
MAP3K MEKK1, MAP3K1 (<1495aahuman, <834 aamouse, 1493 rat)
induce/protect
activate
 activate Axin, RIP, GCK, TRAF2, 14-3-3s, MKK4, JNK, hUBC9, Tax, Ras, Raf1, HAN11, HGK, GSK3b, GST M1-1 p115RhoGAP, a-actinin, RING/kinase
L 1 5q11.2 HBx, CD40,VIP, cisplatin, Stat4 ubiquitous (highest in B)
 PAK3, PKC, c-Abl, NF-IL6 casp, Ub

MAP3K2, MEKK2 (human, mouse)
activate
 activate Rac, CDC42, PRK2, MEK5, Lad/RIBP, 14-3-3s, RD/kinase
L 1 2p14-q14.3 EGF, RANTES; SMURF1
 ubiquitous
IgE, c-kit, Ub

MAP3K3, MEKK3 (human, mouse)
activate
 activate Rac, CDC42, MEK5, 14-3-3s, RIP RD/kinase
L 1, 2 17pter-p13.1 M-CSF, E2F1, AgII, IL10/LPS, OX-CA, progesterone
 preAPC
casp3

MAP3K4, MEKK4, MTK1 (human), D-MEKK1 (Dm)
(-)
 activate Rac, CDC42, 



6q26 RA hemato.
 RA

MAP3K5, Ask1 (human, mouse), C.e.,D.m.(partial)2
promote/inhibit
inhibit,(-)
 activate DAXX, Ask2, PP5, SKRP1, JIP3, Hsp72, IGF-IR, D53L1, Akt2, TRAFs RD/kinase
L 1,2(p?),3,4 6q22.33 CD3, PMA, hypoxia, Dex, Myc; IFNg, NO ubiquitous
Akt, thioredoxin, Ub

MAP3K6, Ask2,(human,mouse)

week. act. Ask1 RD/kinase

1 1p31-32
lung


MAP3K7, TAK1(human a, b, c, mouse, frog), dTAK( fly)
mediate
activate
 activate TAB1, PP2Cepsiron, TAB2, TAB3, IKKs, Hgs, Ras, PAK1, JNK1, XIAP, NAIP, Nod2, Sef kinase/RD
L 1, 2 6q14-q21 E2F1, KF1B, LPS, Hi, Subst.P, p38, insulin ubiquitous
autoactivate

MAP3K8, c-COT, EST, TPL2 (human, mouse)
induce
 activate activate KSR, TRAF2, NIK, ABIN2, p105
 kinase/RD
L
10p11.2 LPS, TNFa, IL1, IL10, PMA, STAT3, AIRE, estrogen, PGJ2 derivative B, NK, APCs


MAP3K9, MLK1(human)
induce
activate
kinase/cc


14q24.3-q31 IFNs ubiquitous


MAP3K10, MLK2, MST (human)
induce
activate
SH3/kinase/cc


19q13.1-q13.2 HOX11
 ubiquitous


MLK4b, KIAA1804 (human)



SH3/kinase/cc


1q42
ubiquitous


MAP3K11, MLK3, SPRK, PTK1(human)
induce
(-)
 activate MLK-3, hsp90, cdc37 SH3/kinase/cc/CRIB/P-rich

1 11q13.1-q13.3 APC, Ma, RA ubiquitous


MAP3K12, ZIPK, DLK, DAPK3 (human,mouse)
mediate
activate ZRP(rat), AATF(rat), par-4 kinase/LZ/LZ

1 19p13.3 Hp ubiquitous (highest in brain)


DRP-1, DAPK2 (human)
induce

CaM



15q22.2 Stat4, phenytoin ubiquitous


MAP3K13, LZK(human,mouse)

activate
kinase/LZ/LZ


3q25-q29
ubiquitous


ZAK,MLTK, AZK (humanalpha, beta)

activate
kinase/SAM


2q24.2
ubiquitous


TOPK (human)



kinase


8p21.2
preB, bone marrow endothelial


FLJ34389 (human)



kinase


16q22.3
preAPC

MAP2K MEK1, MAP2K1, PRKMK1 (human)
inhibit

Raf, B-Raf, Erks, Grb10, Myc,

1
15q21 TNFa, CD3, SCF, FSH, RA, Tc ubiquitous (highest in brain, preB)
 PAK1

MEK2, MAP2K2, PRKMK2 (human)
inhibit?

Raf, B-Raf, ERKs, KSR



7q32 CD3, Ma, MVA, RA ubiquitous


MEK3,MAP2K3, MKK3, ,PRKMK3 (human)  




1
17q11.2 Rb2, MeDNA, Ma, HHV8, DIM, progesterone
 erythroid


SEK1, MKK2, MEK4, JNKK1, PRKMK4, MKK4, MAP2K4 (human)
inhibit

JIP3, YopJ, MEKK1, b-arrestin2,

L
17p11.2 HBV,  TNFa, Fas, camptothecin, cisplatin, DIM, I3C, Blimp1 ubiquitous
peripheral lymphoid homeostasis, liver development

MEK5, PRKMK5, MAP2K5 (human)
inhibit?






15q22.2-q22.31 HBV, MVA, Blimp1, STAT3
 ubiquitous


MKK6, MAP2K6, PRKMK6(human, mouse)
inhibit/mediate
activate
 activate



1 17q24.3-q25.1 hypoxia-ischemia, OX-CA ubiquitous


MKK7, JNKK2, MAP2K7,PRKMK7 (human)


SKRP1, JIP3

L
19p13.3-p13.2
ubiquitous
targets
MAPK Erk1, MAPK3, PRKM3, p44 (human)
inhibit
activate MEKs, IEX1

L
16p11.2 Tprim, Hi, irrrad, UVB, DIM, I3C, TRH
 ubiquitous (highest in brain)


Erk2, PRKM1/2, MAPK1 (human)
inhibit
activate MEKs
L

22q11.2 LPS, PGN, MDP ubiquitous (highest in NK)
casp

p38, SAPK2A, CSBP1, MXI2, MAPK14 (human,mouse)
mediate/inhibit
activate MEKs, DUSPs, HePTP, Elk1, CREB, ATF2

L
6p21.3-p21.2 LPS, hsp65, MeDNA, Hi,
Ld, CD40, GM-CSF, c-Myc, RA, 		 hemato.
 nPKC

Erk3, PRKM6, MAPK6 (human)


PKCb,



15q21 DEX, IL12, TGFb, FceRI, UVB preB, epithelial


MAPK4, PRKM4, p63MAPK, ERK3-related (human)







18q12-q21 SCF, FSH, ErbB4, estrogen
 ubiquitous


p38delta, SAPK4, MAPK13 (human)







6p21.1 estrogen, methamphetamine B, T, NK


Erk5, PRKM7, MAPK7, BMK1 (human)
inhibit

14-3-3b

1
17p11.2 MEKK2, EGF, TNFa
 NK, preAPC
cardiovascular develoment

NLK, LOC51701 (human)
inhibit






17q11.2
brain


Erk6, MAPK12, p38gamma (human)







22q13.33
ubiquitous (highest in brain)


SAPK2B, p38beta, MAPK11 (human)







22q13.33 SCF ubiquitous


Erk8 (human)







8
ubiquitous


Jnk1,SAPK1, MAPK8 (human)


MAPKKs, CRK, JIPs, c-Jun, JunB, JunD, ATF2, c-Myc, PAX2, IRS1, WOX1

L
10q21.1 BLP, EDA, Epo ubiquitous


Jnk2, MAPK9 (human)


 

L
5q35 GM-CSF, IL5 ubiquitous


JNK3, MAPK10 (human)
enhance

 

L
4q21-q22 NRF2, Ct, Hp ubiquitous (highest in brain)


RAGE (human)







14q32
testis

MAPKAPK MK2, MAPKAP kinase 2, MAPKAPK2, KCNA2 (human)
(-)
mediate


L
1q32 LPS, PMA, IL5, UVB, Ret
 DC
 IL1, SRF
DAPK DAP kinase 1, DAPK1 (human, C.e.)
promote/inhibit

CaM, actin filaments, DIP1, UNC5H2
 kinase/Ank/GTP/DD L
1 9q34.1 AP1, FKHR, UVB, IL4, TNFa, LPS, Sm
 		placenta
 ARF

DRAK1 (human, Dm), STK17A
induce


kinase

1,2 7q11.1 IL2, Fas, camptothecin NK, B, T
 hypoxia

DRAK2(human, mouse), STK17B
induce


kinase


2q24 IRF3, LPS, camptothecin myeloid
 IL2, Hp
NIK NIK, MAP3K14 (human, mouse)
inhibit
 activate (-) TRAF2,IKKs, Casp8/10 RD/kinase
1,(Aly) 1 2q11.2-q12, 17q21? E2F1, DIM, I3C, D3, TNFa, Lm
 hemato. (highest in B)
 LT, CD40
phosphorylase kinase PHKA1 (human)



PHKA/B


Xq12-q13 TNFa
 ubiquitous


PHKA2 (human)



PHKA/B


Xp22.2-p22.1
ubiquitous


PHKB (human)



PHKA/B


16q12-q13
ubiquitous


PHKG1 (human)



kinase


7p12-q21
ubiquitous


PHKG2 (human)



kinase


16p12.1-p11.2
ubiquitous

SR kinase SRPK1, SFRSK (human)



SF2


6p21.3-p21.2
ubiquitous


SRPK2, SFRSK2 (human)



SF2


5q12.1-q13.2
 CREB, estrogen
 ubiquitous

class name
apoptosis
NFkB
 JNK/p38 Binding partner Structure 3D KO gene locus regulators expression
 signal pathways memo
IKK IKKalpha, IKK1, CHUK (human, mouse)
(prevent)
 activate
NIK,IkB,  IKKs, Act1, FKBP51, CDC37/Hsp90, Vav1, Pan2, TAK1, Src, Asc kinase/Ub/LZ/HLH/GBD
L 1 10q24-q25 LPS, p53, Ets1
 ubiquitous


IKKbeta, IkBKb, IKK2 (human, mouse, rat)
prevent
 activate inhibit NIK,IkB,  IKKs, CDC37/Hsp90, TAK1, Asc, Act1, DBC1 kinase/Ub/LZ/HLH/GBD
L 1 8p12-p11
hemato.
casp 3

oIKK(oyster)
activate

kinase/Ub/LZ/HLH/GBD








DmIKKb/DLAK/DIK/cactus kinase(D.m.)
activate
IKKg kinase/Ub/LZ/HLH/GBD

1, 2 3 89A-89B



TBK IKKi, IKKepsilon (human, mouse)
(prevent)
 activate
TANK, CDC37/Hsp90, kinectin 1 kinase/Ub/LZ/HLH
L
1q32.1 C/EBPs, IL1b, TNFa, RANKL, OX40, M-CSF, LPS, hsp65, Lm
 ubiquitous
 IRF3 PKC pathway?

TBK1, NAK, T2Kh(human, mouse)
(prevent)
 activate
TANK, NAP1 kinase/Ub/LZ/HLH
L
12
ubiquitous
 IRF3 PKC pathway?

DIK2 (D.m.)



kinase/Ub/LZ/HLH

1, 2 2L 38E1-5



IRAK IRAK (human, mouse )
enhance
 activate activate TRAF6, MyD88, Pellino DD/kinase
L
Xq28 IL1, LPS, IFNg, GM-CSF, CpG, hsp65, Lm, Tc, PMA, PI3K, hypoxia-ischemia ubiquitous (highest in epithelial, hemato.)
 IL1, IL18, TLR ligands

Pelle(Drosophila), PIK-1(C.e.)
activate
Tube, DTRAF1, DTRAF2(D.m.), Pellino DD/kinase L 1, Ce L 97F4
lleukocytes, NK
 anti-Fungal

IRAK2(human)
activate
TRAF6, MyD88 DD/kinase

L 3q25-26 LTA, Lm, LLO
 DC, NK
 IL1, IL18, LPS

IRAK-M, IRAK3 (human)
activate/inhibit
TRAF6, MyD88 DD/kinase(inactive)
1 L 12q14.3 IL13 preAPC
 IL1, IL18, LPS

IRAK4, NY-REN-64 (human, mouse)
activate
Pellino DD/kinase
L L 12q12
ubiquitous
 IL1, IL18, LPS
AKT AKT family(list)
inhibit
activate
SH2s, SH3s, Ask1, Smad3, Ft1
 PH/kinase
 1 1

Pax6CREB, PMA, AP1, NF-kB, EV71, T3, Ceramide, H2O2, ILK, estrogen AKT1,2 = ubiquitous, 3= brain
 PI3K, CD19 target genes, p75, casp

SGK (human)
inhibit

BMK1 kinase


6q23 NF-kB, AP-1, TNFa, IFNa, IL8, endostatin, estrogen, D3, CRF, glucocorticoid, aldosterone, serum, insulin, NO, cAMP, ERKs, IKKs, TRRAP, AdV APCs
 ENaC

SGK2 (human)







20q13.2
ubiquitous


CISK, SGKL(human)
inhibit


PX/kinase


8q12.3-8q13.1
APCs, brain
IL3
DD RIP, RIPK1 (human, mouse, rat partial, chicken)
promote/ inhibit
activate
activate
 RAIDD,TRADD,(Fas), FADD, TRAF2, Casp8/10, FIP3, p62, RIP3, CLARP, TRIF, NKAP, EGFR, MEKK1, MEKK3, A20, FAK
 kinase/IM/RIP3BD/DD
L 1 6p24-p25 IL1, Ld, CREB, Csx, M-CSF, TCDD ubiquitous

 TNF family, DNA damage Ub
CARD RICK, RIP2, CARDIAK, RIPK2 (human, mouse, zebrafish)
promote
activate
 activate(?) Nod1,Nod2, CLARP, c-IAP1, TRAF-1,-5,-6, TRAF-2, casp-1, IKKg, COP, p75NTR, TLRs kinase/IM/CARD   L L 8q21 LPS hemato.
 Nod1, Nod2
RIP-B RIP3, RIPK3 (1,2,3)
(human, mouse, rat partial)
promote
 activate/inhibit
RIP, TRAF2, TNFR1 TRIF kinase/RIPBD
1 1 14q11.2
hemato.

RIP3 b (human), g (human) inhibit











ARD PKK, DIK, ANKRD3, RIP4 (human, mouse, X.l., zebrafish)
activate
activate
 PKCbI, PKCd, TRAFs kinase/IM/Ank
1
21q22.3
liver, lung, epithelial, prostate, tong, thyroid
 PKC, PMA casp

CARK (human), mouse, rat, Ce)



Ank/kinase


1p31.1
ubiquitous (highest in liver, brain)

RIP5
 RIP5, DustyPK (human, mouse, rat, chicken, zebrafish, fugu, )
 induce
 (-)

RIP5-N/kinase


1q32.1
ubiquitous

eIF2a kinase PKR, PRKR, p68 kinase, P1/eIF-2a kinase (human, mouse,rat, D.m.)
induce/(-)/ protect
activate
dsRNA, PKR, PACT/RAX, NF90, IKK, NF90, NFARs, nucleophosmin, C114, TRAF2, TRAF5, FANCC
 DSRM/DSRM/kinase DSRM L
2p21 IFNa, IFNb, IFNg, LPS, dsDNA, dsRNA, TRAIL,Ct,UV, (p38) ubiquitous dsRNA casp

GCN2, EIF2AK4 (human, mouse)



RWD/kinase x2

1
 15q14




HRI (human)







7p22



KIS KIS (human, mouse, rat)


p27Kip1, stathmin RPM/kinase


1q23.2
hemato. (highest in NK)

ER-kinase IRE1(human, mouse, C.e. , yeast)
required
required
 TRAF2, JIK YFGL/TM/kinase


16
ubiquitous ER stress

ERN1(human)



YFGL/TM/kinase


16p12
ubiquitous


eIF-2aK, PEK, PERK, EIF2AK3 (human, mouse, rat, C.e.)



YFGL/TM/kinase
L 1 2p12 UV hemato. (highest in B) ER stress
Ulk Ulk1, Unc51 (human)



kinase/?


12q24.3 HCV, Ye ubiquitous


Ulk2 (human)



kinase/?


7p11.2 insulin, IGF-II, methamphetamine brain, spinal cord


CKLiK, CAMK1D (human)



kinase


10p14
hemato., brain

MARK MARK1 (human)



kinase/UbA/KA


1q42.13
brain


MARK2, EMK1 (human)



kinase/UbA/KA


11q12-q13 Rb2 T, NK, B, APCs


MARK3 (human)



kinase/UbA/KA


14q32.3 CD28
 		erythroid


MELK (human)



kinase/LZ/KA


9p13.1
bone marrow


MARK4 (human)



kinase/UBA


19q13.3
ubiquitous


SNF1LK, MSKm Hek2 (human)



kinase/UBA


21q22.3
DC, myeloid, B, NK, epithelial


HUNK (human)



kinase


21q22.1
ubiquitous


ARK5 (human)







12q24.11
 TNFa brain

Pim Pim1 (human, mouse, rat, bovine, cat, zebrafish, Ce)
inhibit

CDC25a,

L
6p21.2 IFNa, IL2, IL5, IL7, VEGF, prolactin, Rb2, PMA, HHV8 erythroid
 Ub

Pim2 (human)
inhibit




1
Xp11.23 IL1, LPS, IL5
 hemato.


Pim3 (human, mouse, rat, quail, Xl,)





1
22
 CRF prostate, salivery gland, heart, epidermis

STK38 NDR, STK38 (human)







6p21 LMP1, D3 T, NK


STK38L (human)







12p12.1
ubiquitous

TESK TESK1 (human)


14-3-3beta, sprouty4 kinase/?


9p13
ubiquitous
testis

TESK2 (human)



kinase/?


1p32
ubiquitous

MAST205 MAST205, MAST2 (human)
mediate/ inhibit
TRAF6
 kinase/PDZ


1p34.1 CIITA ubiquitous
Ub
LIMK LIMK1 (human)


LIMK1, neuregulins, 14-3-3zeta LIM(ZnF)x2/PDZ/kinase


7q11.23 Subst.P, LPS ubiquitous ROCK, MRCKalpha

LIMK2 (human)
(inhibit)


LIMx2/PDZ/kinase
1
22q12.2
PBL, placenta, epithelial
 MRCKalpha
RAF Raf-1, C-Raf (human, mouse, chick, Xenopus)
prevent
activate
activate
 Ras, MEK1, MEK2 kinase

1 3p25 IL5, FSH, Rb2, Hi, cisplatin, 5FU ubiquitous


A-Raf, PKS2, ARAF1 (human)


CK2beta RBD/DAG(ZnF)/kinase
1
Xp11.4-p11.2 IGF1, Ld, SDF1, PXR, GR,  ubiquitous (highest in hemato.)


B-Raf (human, mouse, quail)
inhibit
activate
 Ras, Rap1, Rheb,14-3-3, MEK1, MEK2, PA28a, RBD/DAG(ZnF)/kinase
1 1 7q34 LPS, Ld, EV71, Epo ubiquitous NGF, cAMP, b2AR, a2AR, SGK, Akt,
RSK RSK1, RPS6KA1 (human)





L
3 IFNa hemato.


Rsk3, RPS6KA2 (human)







6q27 Lm lung, brain, spinal cord


RSK2, RPS6KA3 (human)



kinase x2


Xp22.2-p22.1
oocyte


MSK2, RPS6KA4 (human)



kinase x2
L
11q11-q13
ubiquitous H3, HMG14

MSK1, RPS6KA5 (human)
inhibit/mediate?


kinase x2
L
14q31-q32.1
ubiquitous


RSK4, RPS6KA6 (human)







Xq21
ubiquitous


RPS6KB1, S6K1, STK14A (human)





L
17q23.2
ubiquitous


MNK1, MKNK1 (human)


eIF4E,  Erks, p38,  Pak2
 kinase
1
1p34.1
ubiquitous


MNK2, GPRK7, MKNK2 (human)


Erk2, ERbeta

1
19p13.3
hemato.

PKC PKCalpha, PRKCA (human, mouse,rat)
inhibit/promote/(-)
activate
induce
 RACK C1x2/kinase

1 7q22-q23.2 NRF2, IRF4 brain, spinal cord
casp

PKCbeta, PRKCB1 (human b1,b2), rat (b1), mouse
inhibit/mediate
activate
mediate
 RACK, ERK3, PKK C1x2/kinase
L 1 16p11.2 LPS, Hp, Sd, PMA, brain, B, T, NK, APCs


PKCgamma, PRKCG (human, mouse)

induce
C1x2/kinase
1
19q13.4
brain (highest in amidala)


PKCdelta, PRKCD (human, mouse, rat)
mediate/inhibit
 activate
mediate
 PKK, Stat3, Rad9 C1x2/kinase
1
3p21.31 LPS, Ma, Sm, HHV8, c-Myc, ER, SDF1, phencyclidine, estrogen, progesterone,  RA, cisplatin APCs, preB, NK
casp/(-)

PKCepsilon (human, mouse, rat)
inhibit/mediate
activate
activate
 RACK

L 1 2p21 TNFa, Nef, brain IFNg/JAK/STAT casp

PKCeta, PKC-L, PRKCH (human, mouse, rat)
promote/inhibit
mediate




14q22-q23 Pa, CREB NK, (T)


PKCiota, PRKCI (human, zebrafish), PKClambda (mouse)
suppress
mediate



1
Xq21.3 IL1, Pa, VEGF ubiquitous


PKCmu, PKD, PRKCM (human)
inhibit/promote
activate
Kidins220 C1x2/PH/kinase


14q11
ubiquitous


PKCtheta, PKCq, PRKCQ (human, mouse)
inhibit/mediate
activate
activate
 IKK, BTK, SPAK, Akt1 C1x2/kinase
1 1 10p15 NRF2, T3, Yp NK, T, bone marrow
 TCR/CD3/CD28, IFNs

PKCzeta, PRKCZ (human, mouse, rat)
meditate?
induce
mediate


L
1p36.33-p36.2 HNF4a brain, placenta, lung
casp

TPA-1 (Ce), PKC1B (Ce), kin-11 (Ce), F09E5.1 (Ce), PKC 98E (Dm), Pkc53E-P1(Dm), PCK2 (Sp), PKC1C(Sc)
PDK1
 PDK1, PDPK1 (human)


CARD11
 kinase
L
16p13.3

Insulin, grwoth factors, TCR
KSR KSR, KSR1 (human, mouse, zebrafish, Dm, Ce)
inhibit
activate/(-)
 14-3-3, Raf(-), MEK1, MEK2, Cot C1/kinase C1

17q11.2
ubiquitous


KSR2 (human)







12q24.23
KSR2 (highest in brain)

PKN PKN, PRK1, PAK1, PRKCL1 (human)


Rho, PLD1, neurofilament L, HPV E6, HR1x3/C2/kinase


19p12 b-glucan B, T, NK, APCs
 PI2, PI3, uFAs, PDK1, casp

PRK2, PAK2, PRKCL2 (human)


Rho, Rac, MEKK2, HR1 x3/C2/kinase


1pter-p13.2
ubiquitous cardiolipin
ROCK ROCK1 (human)



kinase/HR1/PH


18q11.2
B, T, NK, APCs


ROCK2 (human)



kinase/HR1/cc/PH
1
2p24
brain, umbilical cord

PKA, GK PKA alpha, PRKACA (human)
activate/inhibit
PKA subunits

1
19p13.1 GM-CSF ubiquitous


PKA beta, PRKACB (human)


PKA subunits



1p36.1 UVB
 brain, spinal cord, B, T, NK


PKA gamma, PRKACG (human)


PKA subunits



9q13
ubiquitous


PRKX (human)







Xp22.3 hypoxia-ischemia hemato.


PRKY (human)







Yp11.2
ubiquitous (highest in T)


cGK I, PRKG1 (human)







10q11.2
ubiquitous


cGKII, PRKG2 (human)







4q13.1-q21.1
ubiquitous

BIKE
 BIKE (human)



kinase/?


4q21.23
 Bmp2, IFNa ubiquitous (highest in BM)

CAMKK CaMKKalpha, CAMKK1 (human)







17p13.3
ubiquitous (highest in brain)


CaMKKbeta, CAMKK2 (human)







12q24.2 HNF4a, Rb2 ubiquitous (highest in brain)

Ca/CaM PK CAMK1 (human)



kinase


3p25.3
ubiquitous


CaMK1G (human)



kinase/?


1q32-q41
brain


MGC8407 (human)



kinase/?


3p21.31
brain


PSKH1 (human)







16q22.1
ubiquitous


PSKH2 (human)







8q21.13
ubiquitous


Ca/CaMPK IIA, CAMK2A (human)
induce
mediate



1
5q33.1
brain


CAMK2B (human)







7p14.3-p14.1
brain


CAMK2G (human)







10q22
brain


CAMK2D (human)







4q25-q26
brain


Ca/CaMPK IV, CAMK4 (human)
inhibit
induce





5q21.3
ubiquitous
casp3, calpain

STK33 (human)







11p15.3
testis


DCAMKL1 (human)



DCXx2/kinase


13q13-q14.1
brain, spinal cord


MGC45428 (human)



DCXx2/kinase


4q31.22
brain, spinal cord

LIN2 LIN2, CASK (human)



kinase/L27x2/MAGUK(PDZ/SH3/GuK)


Xp11.4
ubiquitous

STK29 STK29 (human)



kinase/(STK29-C)


11p15.5
brain


KIAA1811 (human)



kinase/(STK29-C)


19q13.4
brain

class name
apoptosis
NFkB
 JNK Binding partner Structure 3D KO gene locus upstream regulators expression
 signals memo
HIPK Hipk1, Nbak2 (human)
inhibit

p53 kinase/HIPK-C
1
1p12 TNFa
 bone marrow, T, NK


HIPK2 (human)
promote

Fas, p53, p73, Ski
 kinase/HIPK-C


7q32-q34 HCV, JNK
 ubiquitous (highest in brain)


HIPK3/MYAK/NBAK3/PKY/FIST(human, mouse)
inhibit/(-)
induce
 Fas, Nkx-1.2 kinase/HIPK-C (ID/PEST/YH)

1 11p13 KF1B ubiquitous


HIPK4 (human)







19q13.2



LKB1 LKB1, STK11 (human)
mediate

p53 kinase
L
19p13.3 UVB; STRAD erythroid
 targets Peutz-Jegher syndrome
Src BTK (human)
mediate
mediate
induce
 caveolin-1, Btk IL6ST, TLR4, 6, 9, DDR2 PH/Btk/SH3/SH2/kinase

xid Xq21.33-q22
APCs, B, NK


BMX (human)
inhibit

caveolin-1 PH/Btk/SH3/SH2/kinase


Xp22.2
ubiquitous (highest in PBL)
 PKCd, IL3, GCSF

Tec (human)


Lyn, c-kit, IL6ST,
Vav, SOCS1
 PH/Btk/SH3/SH2/kinase


4p12 PU.1, Sp1
 B
 IL3, IL6, SCF, G-CSF, TPO, GPRs

c-Src (human)
mediate/inhibit
mediate
induce
 SH2s , SH3s, TNFR1, CIN85, IKK SH3/SH2/kinase


20q12-q13 TRH ubiquitous CD3

FYN, SYN, SLK (human)
induce
activate
PI3K, PTPalpha,SKAP55, SLAP-130, Csk SH3/SH2/kinase
L
6q21 SDF1, TCR/CD3, CRF, TRAIL, IL15, UVB, irrad,  HOX11, EBV NK, T
casp3

FRK, GTK, RAK (human)



SH3/SH2/kinase


6q21-q22.3 SCF ubiquitous


Lck (human)
mediate
mediate
mediate
 TCRs, SLP76, Csk SH3/SH2/kinase 1 L
1p35-p34.3 PMA, HCV T, NK


Hck (human)
inhibit

C3G SH3/SH2/kinase L

20q11-q12 GR, NRF2, AIRE
 APCs
 EBV

Srms, SRM (human)



SH3/SH2/kinase


20q13.33
ubiquitous


BRK, PTK6 (human)



SH3/SH2/kinase


20q13.3
ubiquitous (highest in epithelial)


ABL1 (human)
inhibit

p53, CD19 SH3/SH2/kinase L L
9q34.1 Subst.P, UVB preB
casp

ABL2, ABLL, ARG (human)
enhance


SH3/SH2/kinase


1q24-q25
ubiquitous


Fgr (human)
inhibit

HS1 SH3/SH2/kinase
L
1p36.2-p36.1 RANKL, Ma NK, APCs
 Csk Ub

YES1, c-yes (human)



SH3/SH2/kinase


18p11.31-p11.21 IL2, PMA, EV71 epithelial, sm. muscle, cardiac


Csk (human)


Fyn, TCR, Lck SH3/SH2/kinase
L
15q23-q25
hemato.


CTK, HYL, CHK, LSK, MATK (human)


ErbB2, Kit SH3/SH2/kinase


19p13.3 IL4, IL13 NK, T


Txk, RLK (human)



SH3/SH2/kinase
1
4p12
NK, T TCR

Blk (human) inhibit


SH3/SH2/kinase
1
8p23-p22 BSAP, AIRE, TCR, Hi, progesterone B
 BCR

Syk (human)
inhibit
mediate
activate
 Vav SH2x2/kinase
L
9q22 AP1, LPS, APC, TNFa, IL1, IL5, SCF, androgen APCs, B
Akt pthwy

ZAP70, SRK (human)
mediate
mediate
Vav, SH2x2/kinase
L
2q12 LPS, Sm
 NK, T
 VHR

Lyn (human)
inhibit

BCR, GADD34, GAP, GM-CSF Rb, IgER, PI3K, Tec, HS1

L
8q13 TNFa, TRAIL, HCV B, NK, APCs
 TCR, BCR targets

Itk (human)


Cbl, Fyn,PKC, CD28 PH/BTK/SH3/SH2/kinase
L
5q32 CD28, IL2, Src, PI3K, Fyn, Lck, CypA T, NK
 TCR
Fes Fes (human)
inhibit

PI3K, STAT3 FCH/ccx2SH2/kinase
1
15q26.1 Spi1, Sp1, PU.1, APCs
 IL4, IL10/12, Sm

Fer (human)


pp120, IRS1, PI3K, plectin FCH/ccx2SH2/kinase
L
5q21 high aff. IgER, GnRH ubiquitous p38
Tyk2 Tyk2 (human)


Vav, B41/SH2/kinasex2
L
19p13.2 ARNT2, IFNa hemato.

Tnk1 Tnk1 (human)


PLCg1 kinase/SH3


17p13.1 b-glucan ubiquitous

ACK1 ACK1 (human)



kinase/SH3/UbA


3q29
ubiquitous


MLK4b, KIAA1804 (human)



SH3/kinase/cc


1q42
ubiquitous

JAK JAKs, see list
class name
apoptosis
NFkB
 JNK Binding partner Structure 3D KO gene locus upstream regulators expression
 signals memo
InsR IGF1R (human)
inhibit
 activate activate IGF1, IGF2, EHD1, SNAP29
 L/Furin/L/FNx3/TM/kinase
L
15q25-q26 SCF, IGF1, CNTF, IL3, OX40, TNFa, IFNg, bFGF, AgII, Vit.A, RA, c-Myc, Sp1, WT1, KLF6, p53, BRCA1, MeDNA,
 ubiquitous
Akt-mediated

Insulin R, InsR (human)
inhibit

Insulin, IGF2, IRSs, Shc, Cap, Grb10, PTP1B, GRB14, TCPTP, SOCS1, SOCS6 L/Furinx2/L/FNx2/TM/kinase
L
6q22 Vit.A, NO, Subst.P, HOX11
 pancreas, adrenal cortex


IRR, InsRR (human)



L/Furin/L/FNx3/TM/kinase


1q21-q23
ubiquitous

EGFR EGFR, ErbB1 (human)
inhibit

EGF L/Furinx2/L/FNx3/TM/kinase
1
7p12 WT1, ARNT2, UVA, estrogen, b-catenin
 placenta, epithelial,


ErbB2, NGL,TKR1, Neu, HER2 (human)
inhibit

NDF, Chk, ERBIN L/Furinx2/L/Furinx2/TM/kinase
L
17q21.1 CSBG, Sp, RA, HIV Vpr ubiquitous
targets

ErbB3, HER3 (human)





1
12q13 HNF4a, STRA13, Ma, UVB ubiquitous


ErbB4, HER4 (human)





L
2q33.3-q34 Epo ubiquitous
targets
Trk TrkA, NTRK1 (human)
induce/ inhibit

BDNF, caveolin, p75NTR LRR/IG/TM/kinase
1
1q21-q22 PTH, IL4, TGFb, Brn3A/(-) dorsal root ganglia


TrkB, NTRK2 (human)
inhibit

BDNF, LRR/IG/TM/kinase
L
9q22.1
brain


TrkC, NTRK3 (human)
inhibit/induce


LRR/IG/TM/kinase


15q25
brain

IG/FN ROR1, NTRKR1 (human)



IG/Fz/KR/TM/kinase
1
1p32-p31
ubiquitous


ROR2, NTRKR2 (human)



IG/Fz/KR/TM/kinase
1
9q22
ubiquitous


Axl, Ark(human 1, 2)
inhibit

Gas6, C1-TEN IGx2/FNx2/kinase
L
19q13.1 SCF, FSH, LMP1, UVB, HPV16, ribavirin umbilical cord


Tie1(human)
inhibit

angiopoietins IG/EGFx3/IG/FN3x3/TM/kinase
1
1p34-p33 cisplatin, VEGF, HEX, b-catenin
 lung, bm, placenta, umbilical crd


TEK, Tie2 (human)


angiopoietins IG/EGFx2/IG/FN3x3/TM/kinase


9p21 HEX lung, placenta, umbilical crd


c-Mer, Mertk (human)
inhibit (clearace)
induce

IG/FN/kinase
L
2q14.1
ubiquitous PI3K clearance of apoptotic cells

Tyro3, Sky, Rse, Etk3, Brt, Dtk, Tif (human)
inhibit


IG/FNx2/kinase
L
15q15.1-q21.1 A2aR,  CSBG brain


MYLK, telokin (human)
accelerate
  

IGx2/FN/kinase/IG


3cen-q21
uterus, prostate, bladder, ovary
Myosin L

MSP-R, RON, MST1R, CD136 (human)
inhibit
MSP, Cbl

1
3p21.3
ubiquitous
Ub

c-Fms, CSF1R, CD115 (human)


CSF-1



5q33-q35 GM-CSF APCs, placenta


FLT, FLT1 (human)



IGx7/TM/kinase
1
13q12 FKHR, HCV, HHV8 ubiquitous


STK1, FLK2, FLT3, CD135 (human)
inhibit


IGx2/TM/kinase


13q12
DC, CD34+ bm


FGFR1, FLT2, FLG (human)
 inhibit
   induce


Pfeiffer
8p11.2-p11.1 SCF, CNTF, AP1, Ct, RA, D3, HCV ubiquitous


FGFR2, KGFR, TK14, BEK (human)
regulate?

Pyk2

L
10q26 CRF, GR, 5FU spinal cord, brain


FGFR3, (human)
inhibit

Pyk2
 IGx3/TM/kinase
L
4p16.3 Ct, Sp1 spinal cord, brain


FGFR4, TKF (human)



IGx3/TM/kinase


5q35.1-qter AP2, c-Myc lung, liver


VEGFR3, Flt4, (human)


VEGF IGx6/TM/kinase
1
5q35.3 Prox1, b-glucan ubiquitous


CCK4, PTK7 (human)



IGx6/TM/kinase


6p21.1-p12.2
ubiquitous


MuSK (human)
inhibit

dishevelled IGx3/Fz/TM/kinase
1
9q31.3-q32
ubiquitous


KDR, VEGFR, VEGFR2, FLK1 (human)


VEGF IGx7/TM/kinase
L
4q12 Mt, Myc, VEGF, TNFa, IL1, HEX, Cbl ubiquitous
Ub

PDGFR alpha, PDGFRA, CD140a (human)
inhibit

PDGF, PLC, Src, Fyn, c-Yes, p85, APS IGx3/TM/kinase
1
4q12 AgII, A2aR, TGFb, estrogen ubiquitous


c-KIT, SCFR, CD117 (human)
inhibit

SCF, Chk, MUPP-1, Stat1, GRB2, BRB7, Tec, SHP1, JAK2, c-Cbl

mi, W, 1
4q12 Brn3a, PTH, GATA1, TAL1, TCR, GR, FK506, CsA, FceRI CD34+ BM, thyroid
SCF targets

PDGFR beta, PDGFRB, CD140b (human)


PDGF BB,

1
5q31-q32 CLOCK ubiquitous


STYK1, DKFZp761P1010 (human)



TM/kinase


12p13.2
brain

ephrin receptor (see ligand list)
 EphA1 (human)







7q32-q36 B-Myb, FKHR, TNFa, Mt, St, Ye, flagellin ubiquitous (highest in epithelial)


EphA2, Eck (human)
induce
activate ADAM10 Epharin_LBD/EGF/FN3x2/TM/kinase/SAM
1
1p36 p53, p63, p73, Myc, estrogen, androgen, E-cadherin, PDGF, P2Y2 epithelial
Ub(Cbl)

EphA3 (human)


ephrin-A5

1
3p11.2 IL1, IGF1, CD28
, DNA methylcase
 ubiquitous


EphA4 (human)


ephrin-B3

1
2q36.1 Egr2 brain


EphA5, HEK7, EHK1, BSK (human)


ephrin A2, A5
 Epharin_LBD/EGF/FN3x2/TM/kinase/SAM
L
4q13.1
brain


EphA7, HEK11 (human)


Ryk



6q16.1 b-catenin ubiquitous (highest in brain)


EphA8, EEK, HEK3 (human)





1
1p36.1
ubiquitous


EphB1, HEK6, Net, EPHT2 (human)

regulate
Epharin_LBD/FN3x2/TM/kinase/SAM
1
3q21-q23
ubiquitous


EphB2 (human)


ephrin-A5, B2, Ryk

1
1p36.1-p35 GR, HEX, PDX1, HOX11 ubiquitous


EphB3, ETK2, HEK2, Tyro6 (human)



Epharin_LBD/FN3x2/TM/kinase/SAM
L
3q21-qter
ubiquitous


EphB4 (human)


Ryk



7q22 IL12, irrad ubiquitous


EphB6 (human)

inhibit




7q33-q35
brain

Fak FAK, FAK1, PTK2 (human)
inhibit
 mediate
talin, MEKK1, RIP
 kinase/Paralemmin
L
8q24-qter CIITA, LPS brain
 GH, ECM, EphA2, Akt casp
FA 5 8 C DDR1, NEP, EDDR1,NTRK4, TrkE, DDR, MCK10, PTK3, CAK (human) inhibit/(-)
 mediate activate/ inhibit
 collagen
 FA58C/TM/kinase
L
6p21.3 p53
 brain, spinal cord
 DNA damage
,  38/TRAF6

TKT, DDR2, Tyro10, NTRKR3 (human)


collagen, Src, Shc
 FA58C/TM/kinase


1q12-qter Zta adrenal, adipocyte

Ryk Ryk (human)


EphB2, EphB4, EphA7

1 1 3q22 IL13 ubiquitous

Alk Alk, Ki-1 (human) inhibit

pleiotrophin, Midkine, PI3K, PLCg, NIPA
 LDLa/MAM/ZnF/Alk-N/TM/kinase


2p23
ubiquitous


Ltk (human) inhibit

PI3K, calnexin
 Alk-N/TM/kinase


3q21-q23
DC

ROS c-Ros, ROS1, MCF3 (human)



DUF139/FN3x2/LY/FN3/LYx2/FN3x6/TM/kinase/ROS-C
L
6q22 ErbB4 ubiquitous


AATYK, AATK (human, mouse)
facilitate


kinase/ROS-C


17q25.3  IL3, GCSF brain, spinal cord


KPI2, KIAA1079, LMTK2 (human)


PP1C, Inh2 TM/kinase/ROS-C


7q21.3
ubiquitous


LMTK3, KIAA1883 (human)



TM/kinase


19q13.33
ubiquitous

Met c-Met, Met, HGFR, RCCP2 (human)
inhibit/(induce)

HGF, PI3K, Fas Sema/PSI/IPTx4/kinase


7q31 LPS, c-Myc, UVA epithelial

Ret RET (human)
induce

GDNF Cadherin/kinase
1
10q11.2 estrogen, PTH ubiquitous
targets
NIPK TRIB3, NIPK, SINK, TRB3, SKIP3, C20orf97(human, rat)







20p12.2-p13 NGF epithelial

ANP R NPRA, GC-A, GUC2A, NPR1 (human)



ANFR/TM/kinase/G cyclase
L
1q21-q22 Cdx2
 ubiquitous  (highest in lung, adipocyte)


ANPRB, NPR2 (human)



ANFR/TM/kinase/G cyclase


9p21-p12
ubiquitous 


ANPRC, NPR3 (human)



ANFR/TM/kinase/G cyclase


5p14-p13
ubiquitous 


RetGC2, GUCY2F (human)



ANFR/TM/kinase/G cyclase


Xq22
fetal liver

GRK RHOK, GRK1 (human)



RGS/kinase


13q34
ubiquitous 


BARK1, GRK2, ADRBK1 (human)


tubulin RGS/kinase/PH
L
11q13 HCV ubiquitous 


BARK2, GRK3, ADRBK2 (human)



RGS/kinase/PH


22q12.1
ubiquitous 


GRK4, GPRK2L (human)



RGS/kinase


4p16.3
testis


GRK5, GPRK5 (human)


actin RGS/kinase


10q24-qter
lung


GRK6, GPRK6 (human)



RGS/kinase
L
5q35 Rb2 hemato.


GRK7, GPRK7 (human)



RGS/kinase


3q23
ubiquitous 


MKNK2, MNK2, GPRK7 (human)


Erk2, ERbeta



19p13.3
hemato.

AMPK AMPK, PRKAA1 (human)


beta, gama



5p12
testis, hemato.
 adiponectin, LKB1

PRKAA2 (human)
enhance




1
1p31
ubiquitous 

TGFR see TGFR family

Review of

CaM kinases by Hook & Means (Annu Rev Pharmacol Toxicol 2001)
G protein-coupled receptor kinase by Pitcher et al., (Annu Rev Biochem  1998)
IKK by Karin (J. Biol. Chem. 1999), by Verma and Jennifer Stevenson (PNAS 1997), by Maniatis (Science 1997), by Stancovski & Baltimore (Cell 1997)
IRAKs by Jassens et al. (Mol Cell 2003)
JNK & NFkB pathway by Karin & Delhase (PNAS 1998)
MAPKs in immune responses Dong et al. (Annu. Rev. Immunol 2002)
Other On-line papers
Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway. Science 1997 Jan 10;275(5297):200-203
Positive and negative regulation of IKK (Delhase et al. 1999)
Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. (Zhang et al. 2000, direct link)
Selective Inhibition of NF-kappaB Activation by a Peptide That Blocks the Interaction of NEMO with the IkappaB Kinase Complex.  (May et al. 2000)
Structure of PAK1 (Lei et al. 2000, direct link)
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway (Senftleben et al., 2001)


Protein Phosphatases
 
group
protein apoptosis NF-kB JNK structure 3D binding partner KO gene locus upstream regulators expression
 signal substrate memo
PTPN








 PTPN13 FAP-1, PTPL1(human) inhibit/mediate/(-) regulate
coiled-coil/FERM/PDZx5/PTP
Fas, p75NTR
1 4q21.3 UV, IL15 ubiquitous


PTPN6 PTP1C, SHP1, HCP, PTPN6 (human)
inhibit/enhance
inhibit? SH2/SH2/PTP  1 P-ITIM (I/VxpYxxL) containing proteins, FcgRIIB1, Vav, Grb2, Sos1, KIRs(Ly-49A),CD45, DOK, BLNK, SLP76, Kit, Fas m,L 1 12p13 NF-kB, Hp, PMA, BCR, IFNa B, T, NK, APCs
DOK,
PTPN11 PTP2C, SHP2, SHPTP2 (human)
inhibit
 (activate?) mediate SH2/SH2/PTP
P-ITIM (I/VxpYxxL) containing proteins, PDHFbR, SHPS-1, CD72, FRS2, Grb2, f-actin, CagA, Fas L 1 12q24.1
ubiquitous insulin

PTPN7 HePTP, PTPN7, PTPNI(human)

inhibit PTP


1 1q32.1 CD30, Hi, GR NK, T, preB, CD34+ bm
 stress

PTPN5 PTPN5, STEP(human)







11p15.2-p15.1
brain, spinal cord


PTPN12 PTP-PEST(human)


PTP
Shc, paxillin, Csk, PSTPIP1, PSTPIP2, Hic-5

7q11.23 TNFa NK



PSTPIP2 (human)


PTP-PEST, 



18q12
ubiquitous (highest in bone marrow)



PTP4A1 (human)


PTP



6q12 FSH ubiquitous


PTPN23
 HDPTP, PTP-TD14 (human)


Bro1/PTP



3p21.3
ubiquitous


PTPN2 PTPT, TCPTP (human)







18p11.3-p11.2 STAT3, IL10, Ld, Lm, Mt, A2aR hemato.


DCP, DUSP DUSP1 MKP1, 3CH134, PTPN16 (human, mouse, chicken)
inhibit/activate
inhibit RHOD/PTP(or DSP)
IKK, p38, MAPK 1 1 5q34 AP-1, Tprim, IL1, TNFa, IL10, p53, CREB, insulin, glucose,ANP, LPS, sBLP, CpG, dsRNA, PGN, Bm, Ld, Lm, Mt, Tg, HHV8, RANTES, TRH, PTH, CRF, EGF, NGF, VEGF, M-CSF, PDGF, FSH, Thrombin, TGFb, mIg, LDL, AA, LPA, RA, RARa,g, NcoRi, calcineurin, Ca, USF, PKA, cAMP, ERK1, MAPK, SAPK, glucagon, AngII, glucose, DEX, YopP, hypoxia,  O stress, NO, p38, Myc, GR APCs
 O2, heat shock  stress, Angiotensin Tyr/Ser/Thr-P

DUSP2 PAC1 (human, mouse)
(-)
inhibit RHOD/PTP 1

1 2q11 c-Myc, p53, NF-kB, IL1b, LPS, MDP, LTA,Yp, Lm, PMA, serum, O stress, ischemia, IKKg, EBV, RA T, NK



DUSP3 VHR (human)
(-)
 inhibit RHOD/PTP


1 17q21 IL2, IL4, IL15 ubiquitous TCR, ZAP70


DUSP4 MKP2, HVH2(human, chicken)

inhibit RHOD/PTP


1 8p12-p11 IL2, FKHR, CD28,  PMA, GnRH, MIP3, MAPK, Ld, Lm, Mt, Tg, D3 placenta, adipocyte, epithelial



DUSP5 HVH3 (human)


RHOD/PTP



10q25 IL2, IL5, IL7, TNFa, BAFF, VEGF, Thrombin, GR, p53, LPS, MDP, Ld, Lm, Mt, Tg, Ye, HHV8, PMA DC



DUSP6 MKP3, PYST1(human, rat)

inhibit RHOD/PTP 1 ERK2
1 12q22-q23 NF-kB,  Brn3a, PLZF, TNFa, IL4, IL8, TGFb, Wnt3a, NGF, NO, RANTES, HHV8, flagellin, MeDNA, estrogen, progesterone, IKKs, LY294002, HHT,  preAPC, epithelial



DUSP7 PYST2(human, rat)







3p21 hypoxia ubiquitous



DUSP8 HVH5 (human)







11p15.5
brain



DUSP9 MKP4 (human,mouse)

inhibit RHOD/PTP



Xq28 HBV liver, kidney, placenta



DUSP10 MKP5 (human, mouse)

inhibit RHOD/PTP

1
 1 1q32 TNFa, Lm, camptothecin, ribavirin preB



DUSP11 PIR1 (human)




RNP

2 p73 epithelial



DUSP12 YVH1 (human, mouse)







1q21-q22
ubiquitous



DUSP13 DSP13 (mouse)









sk. muscle, testis



DUSP14 MKP-L, MKP6, DUSP14 (human, mouse)







17q12 IL15 ubiquitous  (highest in epithelial)



DUSP15 DUSP15 (human)







20q11.1
brain, spinal cord



DUSP16 MKP7, MKP-M (human)


RHOD/PTP



12p13 LPS, CREB, Blimp1, AIRE ubiquitous 



DUSP17/19 SKRP1(human)

inhibit

MKK7, Ask1

2q32.1 c-Myc ubiquitous 




puckered(D.m.)

inhibit PTP(orDSP)


1







123R (CIV)













CDC25
CDC25A (human)
involved

RHOD
Ask1, Pim1
1 3p21 E2F ubiquitous  g-irrad, IL2, RA, AdV



CDC25B (human)







20p13 LPS, Hp, Sp T, NK, B
 sIL6R, IL2



CDC25C (human)







5q31
preB




PPP1CA, PP1A (human, mouse,rabbit) inhibit

IGx3/FN3x8/TM/PTPx2


1 11q13 ribavirin hemato.
 Ras, LPS, PMA

membrane-bound including Receptor-type (PTPR) PTPRJ CD148, SCC1 (human)







11p11.2
ubiquitous 



PTPRH PTPrho (human)







20q12-q13
ubiquitous 



PTPN1 PTP1B (human)


PTP/TM L Band 3, Cas L
20q13.1-q13.2
ubiquitous  PMA, Ld, Lm, Mt, Tg


PTPRF LAR (human) activate

IGx3/FN3x8/TM/PTPx2 1 b-glucan
1 1p32 PDX1
 ubiquitous   (highest in placenta, prostate, epithelial)

3D

PTPRU PTP-J, PCP2, PTPpsi  (human)







1p35.3-p35.1 estrogen ubiquitous  



PTPRS PTPsigma/PTPRS(human)


IGx3/FN3x8/TM/PTPx2
PTPdelta, 1 1 19p13.3 HCV brain, DC?



PTPRH SAP-1 (human)







19q13.4
ubiquitous  



PTPRA PTPalpha, LRP(human)


/TM/PTPx2
GRB2, Fyn,
1 20p13
ubiquitous (highest in brain)



PTPRG PTPgamma(human)


CH/FN/PTPx2


1 3p14.2
ubiquitous  



PTPRD PTPdelta(human)


IGx3/FN3x8/TM/PTPx2
PTPsigma, PTPdelta, 1 1 9p23-p24.3
brain



PTPRE PTPepsilon, PTPRE (human)


/TM/PTPx2

1
10q26 RANKL APCs



PTPRZ1 PTPzeta1/PTPbeta(human)


CH/FN/PTPx2

1 1 7q31.3
brain, spinal cord



PTPRN2 IAR, Phogrin, TC-PTP (human)



1


7q36
brain



PTPRK PTPkappa(human)


MAM/IG/FN3x3/TM/PTPx2


1 6q22.2-q22.3 TRRAP ubiquitous  



PTPRM PTPmu(human)


MAM/IG/FN3x4/TM/PTPx2
PTPmu, RACK1, cadherins,

18p11.2 CREB, BMPs ubiquitous  



PTPRN IA2 (human)



1


2q35-q36.1
brain



PTPRR PCPTP1 (human)







12q13.2-q13.3 CIITA, SCF brain



PTPRO PTP-U2 (human)







12p13-p12 estrogen brain



PTPRB
 PTPRB (human)







12q15-q21
 estrogen ubiquitous  



PTPRC CD45 (human)
regulate

FN3x2/TM/PTPx2
SHP1, CD100 L 1 13 C/EBPa, PU.1, IFNa,  LPS, hsp65, Hp, HCV, PPARa, estrogen NK, T, B, APCs




polycystin 1, PKD1 (human)
inhibit

LRRs/WSC/PKD/CLECT/PKDx16/PTP/GPS/PLAT(LH2)/TMs
PKD2 1, ADPKD
16p13.3-p13.12
ubiquitous  




KIAA0931 (human)


PH/LRRs/PTP



16q22.2
 La(NO3)3 ubiquitous 


PPEF
PPEF1, PP7 (human)


IQ/PTP/EFx3
calmodulins 1
Xp22.2-p22.1
ubiquitous




PPEF2 (human)





1
4q21.1
ubiquitous


PP
calcineurin A alpha, PPP3CA (human) activate/inhibit activate activate

PP2A, Cyclin G2, A283L L 1 4q21-q24 ribavirin brain, B, NK
 TCR/CD3/PMA, Ca, FK506, MEF2, p38, Lyn
regulate NF-AT, casp


calcineurin A beta, PP2A, PP2Ca, PPP2CA (human) inhibit? inhibit? inhibit PP2C
RelA, IGF1
1 5q23-q31 AP-1, c-Myc, Nef, PMA preB
 Yp, D3, Ser/Thr-P casp 3


TAB1, MAP3K7IP1 (human, mouse, frog), TAP1(C.e.)
activate activate PP2C
TAK1, XIAP L 1 22q13.1
ubiquitous




CaMKP, PPM1F, FEM-2 (human, rat, C.e.) induce

PP2C



22q11.22
hemato.




PP4, PPX, PPP4C (human)







16p12-p11
hemato.




PP5, PPP5C (human) inhibit

Tprx3/PP2Ac
Ask1

19q13.3
ubiquitous




PPP6C (human)







Xq22.3
hemato.


Links

Protein Kinase Resource (PKR)
Kinase Pathway Database
Kinase.com
Home page for Calcium Dependent Protein Kinase
Phosphoprotein Database
Copyright by Naohiro Inohara, Department of Pathology, University of of Michigan Medical School
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