| family |
name |
apoptosis |
NF-kB
|
AP1 |
KO |
gene |
Structure |
3D |
locus |
TFs |
regulators |
target |
memo |
IL1 superfamily
|
IL-1a (human
, mouse
, rat
, house
, dog,
sheep,
bovine,
pig,
rabbit) |
inhibit/enhance |
activate
|
activate |
L |
1 |
IL1 |
1 |
2q14 |
AIRE
|
IL1,
IL8,
IL18,
TNFa,
RANKL,
CD8/28,
CD43,
IFNg,
GCSF,
M-CSF,
IL10,
C3b/C4b,
XNA,
PMA,
serum,
EGF,
LPS,
BLP
,MDP,
b-glucan, flagellin,
CpG,
Bm,
Hp, Hf, Pg, St,
Ye,
MVA,
tax,
AmB,
Erks,
RA,
cantharidin |
list |
|
|
IL-1b (human,
mouse,
rat,
house, sheep,
bovine,
rabbit,
dog,
cat,
pig,
chicken,
frog,
r.trout
1,2,
carp
1, 2) |
inhibit/enhance/(-) |
activate
|
activate |
L |
1 |
(TM)/IL1 |
1 |
2q14 |
NF-kB,
NF-IL6,
PU.1,
Sp1,
HSF1,
IRF2,
Gfi1,
EWS/FLI-1,
PPARg,
PDX1,
twist2 |
LPS,
BLP,
MDP,
b-glucan, hsp65,
Bm,
Cp,
Ct,
Ec,
Ft,
Ld,
Lm,
Hi, Ma,
Mt,
Sa,
St,
Tg,
flagellin,
BCG,
dsRNA,
CpG,
EBV,
HHV8,
Tax,
CMV
IE2, VLP,
IL1,
IL5,
IL16,
IL18,
IFNa,
IFNb,
IFNg,
FVIIa,
CD8/28,
XNA,
PMA/Io,
CD43,
MHC,
TNFa,
Fas,
RANKL,
CD40,
Wnt3a,
C3b/C4b,
bradykinin,C5a,
SCF,
histamine,
CRH,
DEX,
D3,
PGE2,
UVB,
HSF1,
RANTES,
CXCL5,
IL2,
IL10,
AgII,
TGFb1,
PAF,
lactoferrin,
Rac2,
FADD,
JNKs,
AmB,
mechanically, |
List,
SAA, |
casp 1 |
|
IL-1Ra (human,mouse) |
inhibit,(-)
|
inhibit
|
inhibit |
L |
1 |
IL1 |
1,
R |
2q14.2 |
NF-kB,
STAT3,
STAT6,
PU.1 |
IL-4,
IL10,
IL13,
CD3/28/TCR,
XNA,
TNFa,
GM-CSF,
SCFPTH,
LPS,
PGN,
MDP,
Sp, MVA,
hypoxia,
Raf-1,
p38,
HCMV
IE1, leptin,
BMP2,
BMPs;
ATP/P2X7
|
INAP |
, TNFa, |
|
IL-18, IGIF(human,
mouse,
rat,
Ap,
chick) |
enhance
|
activate
|
activate |
L |
1 |
(TM)/IL1 |
|
11q22.2-q22.3 |
AP-1,
Elf-1,
IRF1,
ICSBP,
Bcl6 |
IFNa,
IFNg,
ACTH,
TSH,
TRH,
PMA,
LPS,
Cp, Hf, Pg, Sd,
VLP,
estrogen,
androgen,
RON/MSP,
TRIF,
M-CSF,
IL10
|
IFNg,
FasL |
casp 1 |
|
FIL1d, IL1RP3, IL1HY1, IL1F5 (human) |
|
|
|
|
1 |
IL1 |
|
2q14.2 |
|
|
|
|
|
FIL1e, IL1e, IL1F6 (human) |
|
induce
|
induce |
|
1 |
IL1 |
|
2q12-q14.1 |
|
|
|
|
|
FIL1zeta(human),
IL1H(L,S),
IL-1X, IL1F7 |
|
|
|
|
1 |
IL1 |
|
2q12-q14.1 |
|
PMA |
|
binds IL18R,
IL18BP |
|
FIL1eta, FIL1, IL1F8 (human) |
|
induce
|
induce |
|
1 |
IL1 |
|
2q12-q14.1 |
|
|
|
|
|
IL-1H1, IL1RP2, IL1F9 (human) |
|
induce
|
induce |
|
|
IL1 |
|
2q12.1 |
|
ALA
|
|
|
|
IL1F10 (human) |
|
|
|
|
|
IL1 |
|
2q14.1 |
|
|
|
|
|
FGF1/acidic FGF(human,
mouse,
pig) |
inhibit
|
activate
|
|
1 |
|
IL1 |
L |
5q31 |
IRF3 |
|
IL2,
actins,
FR17,
estrogen
|
|
|
FGF2/basic FGF(human,
mouse,
sheep,
frog) |
inhibit
|
|
|
L |
|
IL1, FGF family |
L |
4q26-q27 |
E2F1,
p53,
AP1,
Egr1,
HOXB7 |
OSM,
IL1,
TNFa,
PMA,
serum,
hypoxia,
AgII,
Ye,
heat,
density,
PTH,
FSH,
cAMP,
NAcR,
I3C,
ribavirin, |
list,
actins,
NGFR,
a1, osteocalcin,
elastin,
LDL-R,
D-cyclin,
PGHS-2,
FGFR1,
integrin,
IGF-IR,
b-amyloid,
i.collagenase, |
anti-BMP4 function |
|
FGF3/INT2/(human,
mouse,
frog,
zebrafish) |
|
|
|
L |
|
FGF family |
|
11q13 |
|
RA,
cAMP |
|
inner ear, skeletal |
|
FGF4/HSTF1/HST/KFGF(human,
mouse,
bovine,
chicken,
frog II) |
inhibit
|
|
|
L |
|
FGF family |
|
11q13 |
NF-Y,
Sp1
|
progesterone,
b-catenin |
FGFRs,
prolactin |
inner cell mass, anti-BMP4 function |
|
FGF5 (human,
mouse) |
|
|
|
L |
|
FGF family |
|
4q21 |
|
SCF,
FSH |
|
hair growth |
|
FGF6/HST2(human) |
|
|
|
1 |
|
FGF family |
|
12p13 |
|
MDP,
cisplatin |
|
|
|
FGF7/KGF(human,
mouse,
sheep,
dog) |
inhibit
|
|
|
L |
|
FGF family |
1 |
15q15-q21.1 |
|
estrogen,
SCF,
Subst.P,
LPS,
Pg
|
|
|
|
FGF8/AIGF(human) |
regulate
|
|
|
L |
|
FGF family |
|
10q24 |
|
androgen |
|
limb formation, gastrulation |
|
FGF9(human,
mouse,
rat,
frog) |
inhibit
|
|
|
L |
|
FGF family |
|
13q11-q12 |
HOX11
|
MDP,
Subst.P,
LPS,
MVA |
|
lung branch, sex |
|
FGF10 (human,
mouse,
rat) |
inhibit
|
|
induce
|
L |
|
FGF family |
|
5p13-p12 |
Tbx4
|
TGFb
|
|
multiorgan |
|
FGF11, FHF3(human,
mouse) |
|
|
|
|
|
FGF family |
|
17p13.1 |
|
|
|
|
|
FGF12, FHF1(human) |
|
|
|
|
|
FGF family |
|
3q28 |
CREB |
|
|
|
|
FGF12B(human,
mouse,
rat) |
|
|
|
|
|
FGF family |
|
3 |
|
|
|
|
|
FGF13 (human,
mouse) |
|
|
|
|
|
FGF family |
|
Xq26.3 |
Brn3a
|
|
|
|
|
FGF14/FHF4(human,
mouse) |
|
|
|
1 |
|
FGF family |
|
13q34 |
|
LPS |
|
|
|
FGF15 (mouse,
rat) |
|
|
|
|
|
FGF family |
|
|
|
Subst.P |
|
|
|
FGF16(human,
mouse) |
|
|
|
|
|
FGF family |
|
8p21.3 |
|
|
|
|
|
FGF17(human,
mouse) |
|
|
|
1 |
|
FGF family |
|
8p21 |
|
ARNT2
|
|
cerebella |
|
FGF18(human,
mouse,
rat) |
|
|
|
L |
|
FGF family |
|
5q34 |
|
|
|
|
|
FGF19(human,
mouse) |
|
|
|
|
|
FGF family |
|
11q13.1 |
|
ALA
|
|
|
|
FGF20(human,
mouse,
rat) |
|
|
|
|
|
FGF family |
|
8p22-p21.3 |
|
|
|
|
|
FGF21(human,
mouse,
rat) |
|
|
|
|
|
FGF family |
|
19q13.1-qter |
|
|
|
|
|
FGF22(human,
mouse) |
|
|
|
|
|
FGF family |
|
19p13.3 |
|
|
|
|
|
FGF23(human,
mouse,
rat) |
|
|
|
1 |
|
FGF family |
|
12p13.3 |
|
|
|
|
IL3
|
IL-3 (human,
mouse,
rat,
bovine,
sheep) |
inhibit/(-)
|
initiate
|
|
L |
1 |
|
|
5q31.1 |
NF-kB,
Oct1,
E4BP4,
NF-AT,
YY1,
ASRF, Egr2,
Egr3, DB1 |
CCR3,
JNK,
Ma, b-glucan |
|
T |
| GM-CSF, CSF2 (human,
mouse,
rat,
sheep,
pig,
bovine,
horse,
dog,
cat,
) |
inhibit
|
|
|
L |
|
|
1 |
5q31.1 |
NF-kB,
AP1,
Elf1,
AML1,
Ets1,
Ets2,
EWS/FLI-1,
NF-ATp,
PEBP2,
PU.1,
C/EBPa,
HMG-I,
D3R, |
IL1,
IL2,
IL7,
TNFa,
TWEAK,
GMF,
TCR/CD3/28,
PMA,
FceRI,
CD43,
TREM1,
LPS,
MDP,
CpG,
CSD,
UVB,
hypoxia,
tax,
FK506,
rapamycin,
lactoferrin,
IFNa,
IFNg,
CsA,
glucocorticoids, |
targets |
|
IL2
|
IL-2, TCGF (human,
mouse,
rat,
cat,
dog,
sheep,
bovine,
chicken) |
inhibit/(induce)/(-)
|
activate,*
|
(-) |
L |
1 |
IL2 |
1 |
4q26-q27 |
NF-kB,
AP1,
CREM,
AP3,
ILF1,
c-Myc,
OCT1, NF-AT,
NF-IL6,
IRF4,
PPARg,
Elf1,
PU.1,
YY1,
(review) |
TNFa, IL1,
IL4,
IL7,
IL12,
IL15,
IL17,
IL18,
LFA-1,
TCR/CD3/28/PMA,
CD80,
CD86,
PD-1,
B7H4,
Notch,
TRH,
4-1BB,
TGFb1,
FGF1,
MCP1,
HRF,
Sd,
Sm, Mt,
DEX,
PGE2,
cAMP,
oxLDLs,
FK506,/CsA,
NAC,
Monochloramine,
cannabinoid,
Tax,
CD2,
CD69,
CD101,
EphB6,
ATP,
CB1,
PKCtheta,
Tat,
Tpl-2,
Akt,
Itk,
TRAF5,
IRAK,
JNK,
MEKK2,
Ras,
GILZ,
HuR,
Pim-1,
SSA,
Shc |
targets,
Bcl2,NF-kB,
M-CSF,
c-fos |
|
| IL-15 (human,
mouse,
rat,
dog,
sheep,
bovine,
pig,
chicken) |
inhibit,
(-,
NK) |
|
|
L |
1 |
IL2 |
|
4q31 |
NF-kB,
AIRE |
tax,
IL1,
IL16,
IFNs,
GM-CSF,
PD1,
dsRNA,
B-DNA,
LPS,
sBLP,
MVA,
RON/MSP,
ribavirin,
TRIF,
estrogen,
androgen
|
targets,
IL8, Bcl-xL |
|
| IL-21 (human,
mouse) |
inhibit/
induce
|
|
|
|
|
IL2 |
|
4q26-q27 |
|
|
|
|
IL4 (Th2)
|
IL-4/BSF1 (human,
mouse,
rat, cat, dog,
sheep,
bovine) |
inhibit/enhance
|
inhibit
|
|
L |
1 |
IL4 |
1 |
5q31.1 |
NF-AT,
NFATx,
c-Maf,
NIP45,
NF-Y,
HMG-I,
STAT6,
GATA3,
IRF1,
IRF2,
IRF4,
CIITA,
AP1, JunB,
AIRE,
NF-kB,
C/EBPgamma |
IL25,
IL16,
CD40,
TCR,
PMA,
CD28,
CD86,
B7H2,
IFNg,
Jak1,
Vav,
PKCtheta,
cAMP,
Nef,
EBV, MDP,
Sm, VLP,
CsA,
D3,
androgen |
targets,
Bcl2,
IL6,
,(STAT6) |
B act. |
IL-13 (human,
mouse,
rat,
bovine) |
inhibit
|
inhibit
|
inhibit |
L |
1 |
IL4 |
1 |
5q31 |
GATA3,
IRF4,
c-Myc,
NF-ATs
|
IL25,
IL12,
CD3/28,
PMA,
Hi, Sm, nicotine,
UVB,
CNAIP,
TSH,
TGFb,
HRF,
TIMP1 |
targets
|
|
| IL-5, EDF (human,
mouse,
rat,
cat,
bovine) |
inhibit/enhance
|
|
|
L |
1 |
IL4 |
1 |
5q31.1 |
GATA3,
AP1,
NF-AT,
NFATx,
Bcl6,
ARNT2
|
IL25,
RANKL,
SCF,
CD3/28/TCR,
CD86,
IL10,
cAMP,
PKA,
PMA,
flu
v, CsA,
OX-CA |
targets |
eosinophil trafficking |
IL6
|
IL-6 (human,
mouse,
rat,
bovine,
house,
sheep,
chicken,
fugu)
|
inhibit/induce
|
|
(-) |
L |
1 |
IL6 |
1 |
7p21 |
|