Copyright by Naohiro
Inohara, Department of Pathology, University of of Michigan
Medical School| Index | Caspase | CARD/DED/BIR | Bcl-2 | DD | TNF/TNFR | Kinases | ILs | Viral | Lipid | Engulf | TF | RING | Toll | Other Apop | Other NFkB | Alphabet |
Enzymes of Lipid &
Inohsitol
Metabolism and their Regulators
| Group | Proteins | apoptosis | NF-kB | AP-1 | binding partner | structure | KO | locus | 3D | regulator | expression |
memo |
| PLA2 | IB(human), PLA2G1B | PLA2R | 12q23-q24.1 | IL1b, PLA2R1, Ras, Jnk, Erk, PKCa, PKA, PPARg, NF-kB, C/EBP, WT1 | pancreas |
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| (Lipids>FA+Lyso) | IIA(human), PLA2G2A | inhibit/mediate | potentiate | 1 | 1p35 | NF-kB, PLA2R1, IL1b, TNF, p38, Hp, cisplatin | ovary |
platelets, synovial fluid, secretory, Helicobacter | ||||
| IID, SPLASH, PLA2G2D (human) | 1p36.12 | LT | ubiquitous |
|||||||||
| IVC, gamma(human) PLA2G4A | PLIP/Tip60 | PLA | L | 1q25 | Ca, c-Myc, IL1b, IL4, TGFb, LPS, IKKg, | ubiquitous |
cytosolic, casp1&8 | |||||
| IVC, gamma(human) PLA2G4B | 19q13.3 | ubiquitous | cytosolic, Ca-independent | |||||||||
| V, PLA2G5 (human) | 1 | 1p36-p34 | ARNT2 | heart |
||||||||
| VI, IPLA2 (human),
Ca-independent, PLA2G6 |
prevent | ANKx6/Patatin | 22q13.1 | ubiquitous | cytosolic | |||||||
| VII, PAF acetylhydrase, PAFAH, LDL-PLA2, PLA2G7(human) | 6p21.2-p12 | Brn3a | ubiquitous | |||||||||
| X, SPLA2, GXPLA2, GXSPLA2, PLA2G10 (human) | 1 | 16p13.1-p12 | ubiquitous | secretory | ||||||||
| PLA2R | PLA2R1 (human) | 1 | 2q23-q24 | LPS | ubiquitous | |||||||
| Sphingomyelinase | Acidic, SMPD1 (human, mouse) | (mediate) | L | 11p15.4-p15.1 | Tprim | ubiquitous | ||||||
| Neutral I, SMPD2 (human), mouse, D.m., C.e.., Yeaset(S,c., S.p.), bacteria(Li, Sa., Bc) | (mediate) | FAN | 1 | 6q22.1 | TGFb |
ubiquitous | PLC | |||||
| Neutral II, SMPD3 (human) | 16q22.1 | |||||||||||
| N-SMase??(human) | no homology | |||||||||||
| lipid phosphohydrolase | SPP1, SGPP1 (human, mouse) | enhance | 14q23.2 |
ubiquitous | ||||||||
| FAN | FAN, NSMAF (human,
mouse) |
|
RACK1, N-SMase | Beach/WDx7 |
|
8q12-q13 | ubiquitous (highest in hemato.) |
|||||
| PLC |
beta 1, PLCB1 (human) | PLC-X/PLC-Y/C2/coiled-coil | 20p12 | Ca | brain |
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| beta 2, PLCB2 (human) | PLC-X/PLC-Y/C2/coiled-coil | 15q15 | Ca, Ma | B, T, APCs |
PIP2>IP3+DG | |||||||
| beta 3, PLCB3 (human) | PLC-X/PLC-Y/C2/coiled-coil | 1 | 11q13 | Ca, Sp1, TNF, IL1 | ubiquitous | |||||||
| beta 4, PLCB4 (human) | PLC-X/PLC-Y/C2/coiled-coil | 1 | 20p12 | Ca | (brain) |
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| gamma 1, PLCG1 (human) |
|
activate | inhibit | Tnk1 | PH/PLC-X/PH(SH2/SH2)/PH(SH3)/PLC-Y/C2 | 20q12-q13.1 | Ca, IFNg, D3, a1b1., Vav1, Subst.P, LPS, SLP76 | T |
casp | |||
| gamma 2, PLCG2 (human) |
|
mediate | PH/PLC-X/PH(SH2/SH2)/PH(SH3)/PLC-Y/C2 | L | 16q24.1 | Ca, IRF3, BTK, BCR, SLP76, Nef, | B, NK |
|||||
| delta 1, PLCD1 (human) | PH/EFh/EFh/PLC-X/PLC-Y/C2 | 1 | 3p22-p21.3 | Ca, Nef, LPS, b-glucan, cisplatin | epidermis |
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| delta 3, PLCD3 (human) | 17q21 | NF-kB, TNF, IKKs | ubiquitous | |||||||||
| delta 4, PLCD4 (human) | PH/EFhx3/PLCX/PLC-Y/C2 | 2q35 | bradykinin | ubiquitous | ||||||||
| epsilon 1, PLCE1 (human), alpha | PH/EFh/PLC-X/PLC-Y/C2 | 2q33 | Ca | |||||||||
| epsilon 2, PLCE2, PLCL2 (human) | PH/EFh/PLC-X/PLC-Y/C2 | 3p24.3 | hemato. | |||||||||
| PLD |
PLD1 (human) | inhibit |
PEA15 | PX/PH/PLD/PLD | 3q26 | IL1b/IFNg, RANKL, Ras, PKN | preB |
PC hydrolysis | ||||
| PLD2 (human) |
|
PEA15 | PX/PH/PLD/PLD | 17p13.1 | MSH | ubiquitous | ||||||
| PLD3, HU-K4 (human) | 19q13.2 | pituitary, brain |
||||||||||
| lysophospholipase |
lysophospholipase I, LYPLA1 (human) | abhydrolase lipase-specific/abhydrolase | 8q11.23 | ubiquitous | ||||||||
| lysophospholipase II, LYPLA2 (human) | 1p36.12-p35.1 | ubiquitous | ||||||||||
| lipase |
Lipase A, lysosomal cholesterol esterase, LAL, CESD, LIPA (human) | 1 | 10q23.2-q23.3 | RA, IL13 | ubiquitous | Wolman disease | ||||||
| gastric, LIPF (human) | 10pter-q23.33 | ubiquitous | ||||||||||
| pancreatic, PNLIP (human) | 10q26.1 | pancreas |
||||||||||
| PLRP2, PNLIPRP2 (human) | 1 | 10cen-q26.11 | pancreas |
T cell cytotoxicity | ||||||||
| endothelial, LIPG, EDL (human) | 18q12.1-q12.3 | thyroid, placenta |
||||||||||
| hepatic, HL,LIPC (human) | L | 15q21-q23 | liver |
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| hormone-sensitive, HSL, LIPE (human) | L | 19q13.1-q13.2 | cAMP | adipocyte |
FA | |||||||
| PS-PLA1, PLA1A (human) | 3q13.13-q13.2 | FSH | preB |
PS specific | ||||||||
| PI3K |
p110alpha, PIK3CA (human) | RasBD/C2/PIK/PIkinase | 1 | 3q26.3 | cantharidin, hypoxia | ubiquitous | ||||||
| p110beta, PIK3CB (human) | RasBD/C2/PIK/PIkinase | 3p13-q26.1 | ubiquitous | |||||||||
| p110gamma, PIK3CG (human) | RasBD/C2/PIK/PIkinase | L | 7q22 | estrogen, irrad | ubiquitous (highest in NK) |
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| p110delta, PIK3CD (human) | RasBD/C2/PIK/PIkinase | L | 1p36.2 | hemato. |
||||||||
| 2 alpha, PIK3C2A (human) | RasBD/C2/PIK/PIkinase/PX/C2 | 11pter-p15.5 | ubiquitous | |||||||||
| 2 beta, PIK3C2B (human) | RasBD/C2/PIK/PIkinase/PX/C2 | 1q32 | ubiquitous (highest in placenta,
B, thymus) |
|||||||||
| 2 gamma,, PIK3C2G (human) | RasBD/C2/PIK/PIkinase/PX/C2 | 7q22 | ubiquitous | |||||||||
| 3, PIK3C3 (human) | C2/PIK/PIkinase | 18p11.1-q12.3 | ubiquitous | |||||||||
| PI3K p84alpha, GRB1, PIK3R1 (human) | p110s | SH3/RhoGAP/SH2/SH2 | L | 5q13 | L | IL1b,
LPS,
IKKg,
PMA,
Mad1,
DEX,
KCl |
ubiquitous | |||||
| PI3K p84beta, GRB1, PIK3R2 (human) | p110s | SH3/RhoGAP/SH2/SH2 | 19q13.2-q13.4 | TNFa | ubiquitous | |||||||
| p55gamma, PIK3R3 (human) | SH2/SH2 | L | 1pter-p32.1 | 1 | Hp | ubiquitous |
||||||
| p150, PIK3R4 (human) | kinase/?/?/WD40s | 3q22.1 | ubiquitous |
|||||||||
| IP6K2, IHPK2 (human) |
|
3p24.2-p23 | IFNg | ubiquitous |
||||||||
| PTEN | PTEN/MMAC1(human) |
|
|
PTP | L | 10q23.3 | p53,
Egr1, c-Myc,
NF-kB,
TNFa,
IGF2,
KCl |
ubiquitous | targets, casp | |||
| IPP |
SHIP, INPP5D (human) |
|
|
p85 | SH2/IPPc | L | 2q36-q37 | Smads, Activin, TGFb | B, T, NK, APCs |
|||
| SHIP2, INPPL1 (human) | SH2/IPPc/SAM | 11q23 | ubiquitous (hiest in hemato.) | |||||||||
| OCRL (human) | IPPc/RhoGAP | Lowe | Xq25-q26.1 | ubiquitous | ||||||||
| synaptojanin 1, SYNJ1 (human) | Syja_N/IPPc | 1 | 21q22.2 | brain |
||||||||
| synaptojanin 2, SYNJ2 (human) | 6q25.3 | spinal cord, brain |
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| INPP4A (human) | 1 | 2q11.2 | estrogen | T, NK, preB, brain |
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| INPP5E, 72k (human) | IPPc | 9q34.3 | ubiquitous | |||||||||
| INPP5A (human) | IPPc | 10q26.3 | ubiquitous |
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| INPP5B, 75k (human) | IPPc | 1p34 | LPS, IL10, AIRE | T, preB |
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| SKIP (human) | IPPc | 17p13.3 | ubiquitous |
|||||||||
| PIP5K | PIP5K1A (human) | 1q22-q24 | ubiquitous | |||||||||
| PIP5K1B (human) | FRDA | 9q13 | CIITA | ubiquitous | ||||||||
| PIP5K2A (human) | phenytoin | ubiquitous |
||||||||||
| MAPEG |
leukotriene C4 synthase, LTC4S (human) | MK-886 | MAPEG | 5q35 | NF-kB,
LPS,
TGFb,
IL13 |
ubiquitous |
||||||
| Prostaglandin E synthase, PGES, PIG12, MGST1L1, PTGES (human) | MAPEG | 1 | 9q34.3 | Sp, p53 | ubiquitous | |||||||
| Peroxidase |
COX1, PTGS1, PGHS1 (human, mouse, rat) | COX1 | EGF/perioxidase | L | 9q32-q33.3 | BMPs, cAMP, mechanically | PG | |||||
| COX2, PTGS2, PGHS2 (human, mouse, rat, house) |
|
COX2 | EGF/perioxidase | L | 1q25.2-q25.3 | NF-kB(-), AP-1, CREB, C/EBPs, IRFs, NF-AT, Sp1, p53, c-Myb, PU.1, PPARg, STAT3, p300, Ku70, Ku80, CUGBP2, PMA, IL1, IL8, IL10, IL13, IL18, IL24, IFNg, PDGF, leukotriene, LPS, PGN, MDP, LTA, CpG, Bm, Hp, Ld, Lm, Mt, Ng, Sa, Tg, Ye, dsRNA, RSV, HHV8, PMA, TNFa, hsp60, PP,DEX, UV, O, TGFa,TGFb, AngII, ET-1, bombesin, PDGF, VEGF, Thrombin, M-CSF, cAMP, estrogen, PEA3, PKCa, PKCe, PKA, COT, APC, Wnt, PLCg2, Ras, Rac, p38, HERs, PP1, PP2A, RON, PGE2, microcrystals, AmB | PG, casp | |||||
| TPO (human) | signal/perioxidase/sushi/EGF/TM+Heme | d | 2p25 | thyroid | T3 & T4 | |||||||
| FLJ25471 (human) |
8q11.21-q11.22 | |||||||||||
| D2S448, PXN, MG50, PRG2, peroxidasin (human) | signal/LRRx6/IGx4/perioxidase/VWC | 2p25 | p53 |
sm. muscle | ||||||||
| LPO (human) | signal/perioxidase+heme | 17q23.1 | trachea, salivery gland |
|||||||||
| MPO (human) | signal/perioxidase+heme | d | 17q23.1 | 1 | AML1,
NF-Y,
HBP1,
TNF,
IL3,
staurosporine |
myeloid, CD34+ bm | ||||||
| EPX, EPO (human) | signal/perioxidase+heme | d | 17q23.1 | PU.1,
C/EBPe, |
eosinophil |
|||||||
| dual oxidase 1, DUOX1, LNOX1, THOX1, NOXEF1 (human) | signal/perioxidase/TM/EFhx2/reductase | 15q15.3-q21 | thyroid |
|||||||||
| THOX2, DUOX2 | signal/perioxidase/TM/EFhx2/reductase | 15q15.3 | thyroid | |||||||||
| Uteroglobin |
uteroglobin, UGB, CCSP, blastokinin , CC10, CC16, SCGB1A1 (human) | uteroglobin (dimer), steroids | uteroglobin | 1 | 11q12.3-q13.1 | TTF1 |
lung, trachea |
|||||
| lipophilin A, SCGB1D1 (human) | 11q13 | ubiquitous |
||||||||||
| lipophilin B, SCGB1D2 (human) | 11q13 | skin |
||||||||||
| mammaglobin 2, SCGB2A1 (human) | 11q13 | ubiquitous (highest in
uterus) |
||||||||||
| mammaglobin 1, SCGB2A2 (human) | 11q13 | skin |
||||||||||
| secretoglobin, RYD5 (human) | uteroglobin | 11p15.5 | ubiquitous | |||||||||
| HIN1, LU105, UGRP2, PnSP-2, SCGB3A1 (human) | 5q35-qter | TTF1 |
trachea, lung |
|||||||||
| LU103, PNSP1, UGRP1, SCGB3A2 (human) | 5q32 | TTF1,
Ag,
DEX |
trachea, lung | |||||||||
| IRS |
IRS1 (human, Ca, mouse, rat, chicken, Xl, Dm) |
|
14-3-3s, p85, IR, SOCS1,2, Grb2, IRAS | PH/PTBI/? | L | 2q36 | 1 | IKK, PMA, TNFa, MEKK1 | ubiquitous |
casp |
||
| IRS2 (human, mouse, rat | IR, SOCS1,2, IRAS | PH/PTBI/? | L | 13q34 | TNFa, PTEN, CREB, cAMP, palmitate | myeloid, monocyte |
casp |
|||||
| IRS3 (human, mosue, rat) |
|
IR, IRAS | PH/PTBI/? | 7q22 | placenta |
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| IRS4 (human, mosue) | IRAS | PH/PTBI/? | Xq22.3 | cisplatin | ubiquitous |
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| SDR | SDR (human, mouse, rat) | phosphatidylserine | cc | 2q32-q33 | serum, AdV |
Online References
Review of
Ceramide action by Hannun (Science 1996), Kolesnick & Kroenke ( Annu. Rev. Physiol. 1998)"Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis." Cell 1996 Jul 26;86(2):189-199
COX by Smith et al., (Annu Rev Biochem 2000)
PI3K by Deane & Fruman (Annu Rev Immunol 2004)
PTEN by Dixon et al. (Annu Rev Biochem 2001)
Copyright by Naohiro
Inohara, Department of Pathology, University of of Michigan
Medical School| HOME | All-in-One Seq Analyzer |