| family |
group |
proposed
name |
name |
Apoptosis
|
NFkB act |
KO |
gene |
Locus |
Ligand/Receptor |
Binding partner |
Structure |
gene regulator |
upstream regulator |
tissues
|
memo |
| TNFR family |
|
TNFRSF1B |
TNFR2, CD120B, p80 (human,
mouse) |
promote/inhibit
|
induce |
L |
1,2- |
1p36.3-.2 |
TNF, LTa |
TRAF1,2, FANCD2 |
|
p53,
p73 |
PMA,
RANKL,
Fas,
IL18,
LPS,
Hp,
Ma,
Mt,
Pg, YopP,
TGFb,
irrrad,
camptothecin,
TIMP1
|
APCs, NK
|
|
|
|
LTBR (3) |
LTbR(human,
mouse) |
promote
|
induce |
1 |
1 |
12p13 |
LTa/b |
TRAF2, 3,5, cIAP1,
Smac |
|
|
LPS,
Hp,
PMA,
Raf,
TCDD |
|
|
|
|
TNFRSF5 |
CD40 (human,
mouse,
bovine) |
inhibit/promote
|
induce, B2 |
L |
1 |
20q12-q13.2 |
CD40L |
TRAF2-3,5,6, C4BP |
3D(LRcomplex) |
AKNA,
NF-kB,
STAT1,
PU.1,
Spi-B |
NF-kB,
Sp1,
IL1,
PMA,
TNFa,
RANKL,
IFNg,
GM-CSF,
LPS,
MDP,
Hp,
Ld,
Ma,
St,
VapA,
IL10,
plasmin,
p38,
TRIF,
SOCS1 |
B
|
targets |
|
|
TNFRSF7 |
CD27, S152(human,
mouse) |
inhibit/promote
|
induce |
|
1 |
12p13 |
CD70 |
SIVA,TRAF2,3,5 |
|
|
IL4,
IL2,
IL12,
TNFa,
OX40,
LPS,
b-glucan, Hp,
Nef,
MVA
|
T
|
|
|
|
TNFRSF8 |
CD30 (human,
mouse,
rat) |
promote/inhibit
|
induce |
L |
1 |
1p36 |
CD30L |
TRAF1-3,5 |
|
Sp1,
c-Myc,
Hoxd10 |
CD40,
NAC,
TCDD |
preB
|
|
|
|
TNFRSF4 |
OX40, CD134(human,mouse,rat,dog) |
inhibit
|
induce |
L |
1 |
1p36 |
OX40L(mouse) |
TRAF1-3,5, FIV |
|
|
IL1,
tax,
CD3&IL2,
LPS,
Ma,
Wnt3a,
TCDD |
T, NK
|
T cell response, targets |
|
|
TNFRSF9 |
4-1BB,
ILA,
Ly63, CD137 (human,mouse) |
induce/inhibit
|
induce |
L |
1 |
1p36 |
4-1BBL |
TRAF1-3 |
|
NF-kB,
AP1,
ARNT2 |
TCR/CD8/CD28,
CD43,
M-CSF,
TNFa,
GM-CSF,
TGFb,
T3,
LPS,
MeDNA,
Ec,
Hp,
Mb,
Sa,
St,
BCG,
irrad.,
PTEN,
Gab2,
TIMP1,
ribavirin |
|
|
|
|
TNFRSF18 |
GITR(mouse),
AITR
(human) |
inhibit
|
induce |
|
1 |
1p36.3 |
TL6 |
TRAF1-3 |
|
p53 |
TCR/CD3,
PMA, DEX |
T
|
|
|
|
TNFRSF14 |
HVEM/ATAR/TR2(human),
HveAs(monkey) |
|
induce |
|
1 |
1p36.3-.2 |
LTa,
LIGHT |
TRAF1-3,5 |
|
|
MVA,
hypoxia,
TIMP1 |
B, T, NK
|
|
|
|
TNFRSF11A |
RANK/ODFR(human,mouse) |
inhibit
|
induce |
1 |
1 |
18q22.1 |
RANKL/TRANCE |
TRAF1-3,5 |
|
|
TGFb,
TNF,
RANKL |
|
|
|
|
TNFRSF19 |
TNFRSF19/TAJ/TROY/TRADE(human
a,mouse
aL, as, b1) |
induce
|
induce |
|
1 |
13q12.11-12.3 |
|
TRAF1-3,5,6 |
|
|
|
|
|
|
|
XEDAR |
XEDAR(human) |
induce
|
induce |
1 |
1 |
Xq12 |
EDA-A2 |
TRAF3,
TRAF6 |
|
|
Blimp1
|
|
|
|
|
TNFRSF13B |
TACI (human,
mouse) |
inhibit
|
induce |
L |
1 |
17p11.2 |
TALL1/BLysS,
APRIL |
TRAF2,5,6 |
|
|
|
|
humoral immunity |
|
|
TNFRSF17 |
BCMA, BCM (human,
mouse) |
inhibit
|
induce |
1 |
1 |
16p13.1 |
APRIL, BAFF |
TRAF1-3 |
|
|
MVA
|
DC, B
|
|
|
|
TNFRSF13C |
BAFF-R,
BR3(human,
mouse) |
(inhibit)
|
induce |
1,
A/WySnJ |
1 |
22q13 |
BAFF |
TRAF3 |
w
BAFF |
|
|
B
|
|
|
|
TNFRSF19L |
RELT(human,
macaque) |
|
induce |
|
1 |
11q14 |
|
TRAF1 |
|
|
|
APCs
|
|
|
|
TNFRSF12A |
Fn14, TweakR
(human,
mouse) |
induce
|
|
|
|
16p13.3
|
TWEAK |
TRAF1,2,3,
5 |
|
Lm
|
FGF1 |
epithelial
|
|
|
decoy |
TNFRSF11B |
osteoprotegerin (OPG), OCIF (human,
mouse,
rat) |
promote
|
|
1 |
1,2 |
8q23-24 |
ODF/RANKL/TRANCE,
TRAIL |
|
|
Smads,Cbfa1,
NF-kB |
BLP,
IL6,
OSM,
TGFb,
IGF-I,
TNF,
Lm, a(v)b(3)
integrin, SPARC,
osteopontin,
Fas,
Raf,
PTEN,
camptothecin |
|
|
|
|
TNFRSF10C |
decoy
receptor 1(DcR1)/ TRID/
TRAIL-R3 (human) |
inhibit
|
|
|
|
8p22-p21 |
TRAIL |
|
TRAIL-R like |
p53 |
camptothecin,
irrad. |
PBL
|
|
|
|
TNFRSF10D |
decoy
receptor 2(DcR2), TRAIL-R4/TRUNDD
(human,
mouse) |
inhibit
|
|
|
|
8p21 |
TRAIL |
|
TRAIL-R like |
NF-kB |
PTEN,
Fas |
|
|
|
|
TNFRSF6B |
decoy
receptor 3, DcR3, TR6 (human) |
inhibit/ enhance
|
|
|
1 |
20q13 |
FasL, LIGHT, TL1A |
|
|
|
MeDNA
|
|
T |
|
|
|
TDcR(brook
trout) |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
vTNFR, see viral
regulators |
|
|
|
|
Death Receptor |
TNFRSF6 |
Fas, APO-1, CD95, APT1(human,
mouse,
rat,
pig,
bovine,
chick) |
induce
|
(-) induce/
repress |
L,
lpr,
SLE |
1,2 |
10q24.1 |
Fas-L |
FADD,
CaM,
SHP1,
SHP2,
FAP,
ezrin,
Met |
NMR |
p53,
NF-kB,
AP1,
CREB,
STAT1,
STAT3,
Egr1,
Egr2,
Egr3 |
CD30,
RANKL,
TNFa,
Fas,
OX40,
IL1,
IL10,
IL18,
IFNa,
IFNb/(-),
IFNg/(-),
IL12,
PMA,
CD3,
CD4,
LPS,
Tc, somatostatin,
SDF1a,
VIP,
CRH,
IGFBP2,
oxLDL,
LPS,
dsRNA,
MeDNA,
irrad.,
NO,
cisplatin,
doxorubicin,
TCDD,
5FU,
mitomycin
C, Raf,
ischaemia,
hypoxia,
EphB2,
MKK7,
MEKK1,BRCA1,
p38,FAP1,
TIA1,
Palgin,
estradiol,
RA |
preB |
Ub |
|
|
TNFRSF1A |
TNFR-I/
p55/
CD120a (human,
rat,
mouse,
cat,
pig,
dog,
cow) |
induce
|
induce |
L(874) |
1,2 |
12p13.2 |
TNFa,
LTa |
TRADD,
TRAFs, DAP1,
Stat1,
SODD,
ARTS-1,
FANCD2,
E6,
TRUSS |
Crystal,
DD |
|
IL2,
IL5,
IL10,
IL18,
LPS,
Lm,
Ma,
Pg, Tc, BCR,
UV,
TGFb,
IFNg,
HCV,
PMA,D3,
androgen,
NcoRi,
TCDD,
TGFb |
|
casp7,
Ub |
|
|
TNFRSF12 |
WSL-1,DR3,TRAMP,Apo-3(ref),AIR,LARD(human),
mouse) |
induce
|
induce |
1 |
1 |
1p36.3 |
TL1A |
TRADD |
|
|
CD30,
GM-CSF,
irrrad, |
T, brain
|
|
|
|
NGFR |
p75NTR, Low Aff. NGRF (human,
rat[ref],
chicken,
Xenopus) |
induce/inhibit
|
induce |
L |
1,m |
17q21-q22 |
NGF |
TRAFs, caveolin,
TRADD,
IRAK,
RICK,
NRIF,
NADE,
NRAGE,
MAGE-G1,
FAP-1,
NgR, TrkA,
c-Cbl
|
|
NF-kB,
Ets1,
MITF,
Brn3a/(-)
|
TNFa,
LPS,
NO,
osmotic
swelling, IKKs |
|
neuron innervation, PS,
Ub
|
|
|
TNFRSF10A |
DR4,
TRAIL-R1, Apo-2, CAR1(human,
mouse,
chicken,turkey),
OvTNFR(zebrafish) |
induce
|
induce |
|
1 |
8p21 |
Apo-2L/TRAIL |
TRADD |
|
|
IFNa,
S.t.,
LPS,
adriamycin |
B, T
|
|
|
|
TNFRSF10B |
DR5,
Killer,TRAIL-R2,TRICK2
(human,
mouse) |
induce
|
induce |
|
1 |
8p22-p21 |
TRAIL |
TRADD,
Clarp
|
LBD/TRAIL |
p53,
NF-kB,
Sp1 |
IL1,
TNFa,
IFNg,
Hp,
Dex,
estrogen,
irrad.,
adriamycin |
preB
|
|
|
|
TNFRSF21 |
DR6
(human,
mouse,
chick) |
induce
|
induce |
L |
1 |
6p21.1-12.2 |
|
TRADD |
|
NF-kB
|
TNFa
|
mDC
|
|
|
|
EDAR |
EDAR
(human),
Downless( mouse) |
induce
|
induce |
1 |
ED3,2 |
2q11-q13,15? |
EDA-A1 |
TRAFs,
EDARADD |
|
|
EDA,
Hp |
|
|
|
|
|
ZH-DR
(zebrafish) |
|
|
|
|
|
|
|
|
|
|
|
erythropoiesis |
|
|
|
Wengen
(Dm) |
induce
|
|
|
|
|
Eiger |
dTRAF2 |
|
|
|
|
|
| TNF family |
|
TNF |
TNFa (human,
mouse,
Macaca,
baboon,
An,
Me,
Av,
Pl,
Pm,
rat,
rabbit,
guinea
pig, male,
hamster,
wooodchuck,
Te,
Tv,
horse,
sheep,
goat,
pig,
bovine,
r.deer,
dog,
cat,
Bt,
armadillo,
pika,
kangaroo,
opossum, R.
trout, flounder,
Cd) |
induce/inhibit
|
induce |
L |
1,2,3,4,
5,6,7 |
6p21.3 |
TNFR1, 2 |
LT, TNF
|
3D |
NF-kB,
Bcl3,
AP1,
ATF2,
ARNT2,
Elk1,
Egr1,
STATs,
Ets2,
C/EBPbeta,
HSF-1,
Nrf1,
NFATx,
Gfi1,
(LITAF),
twist2,
CBP/p300 |
LPS,
PGN,
LTA,
MDP,
Ba,
Bm,
Cp,
Ec,
Ft,
Hp, Ld,
Lm,
Ma,
Mt,
Nc, Pg, Py,
Re, Sa,
St,
Tg,
CpG,
BCG,
BLP,
R848,
b-glucan,
TBhsp70,
BCG,
hsp65,
fragellin,
VapA,
S-27609,
dsRNA,
CMV,
HCV
NS3, DV,
EV71,
LeIF,
IL1b,
IL2,
IL4,
IL9,
IL10,
IL12,
IL15,
IL18,
IL19,
CXCL5,
Fas,
CRH,
CD27/CD70, AgII,
G-CSF,
GM-CSF,
M-CSF,
SCF,
ANP,
leptin,
TCR/CD3/28,
PMA,
BCR,
FceRI,
CD43,
TREM1,
CNAIP,
TNFa,
RANKL,
CD40,
4-1BB,
IFNg,
IFNb,
IFNk,
FLT3L,
galanin,
TGFb,
apoptotic
cells, lactoferrin,
p38,
COT,
Brain
injury, tat,
HSV,
Nef,
D3,
IKKg,
TIA1,
MK2,
SP-A,
VHL,
SOCS1,
Cannabinoid,
PGE2,
CsA/FK506,
cisplatin,
doxorubicin,
Epo,
TCDD,
hypoxia,
estrogen,
histamine,
ethanol,
METH,
g-irrad, UV,
YopP,
tax,
HIVp17,
ALA
|
|
targets |
|
|
TNFSF6 |
FasL(human,
Macaca,
Ctt,
mosue,
rat,
pig,
woodchuck,
bovine) |
induce, inhibit
|
induce |
1,gld,
SLE |
1 |
1q23 |
Fas |
Grb2,
actin, b-tubulin, FBP17, PACSIN2 |
|
NF-AT,
NF-kB,
AP1,
Sp1,
Egr1,
Egr2,
Egr3,
C/EBPb,FKHRL1,
CIITA,
GILZ,
c-Myc,p53,
IRF1,
IRF2, ER,
Nur77,
Ets1,
STAT1 |
TNFa,
IL2,
IL6,
IL18,
TCR/CD3/28,
CD30,
IFNa,
IFNg,
prolactin,
PMA,
4-1BBL,
LPS,
MDP,
MeDNA,
Sd,
influenza
virus, IL12,
calcineurin,
JNK,
MEKK1, p38,
PKCtheta,
RA,
D3,
estrogen,
tat,
ALG-4,
Bcl-2,
RANTES,
SDF1a,
VIP,
CRH,
PACAP,
H2O2,
irrad.,
ischaemia,
Bcl-xL,
Itk,
survivin,
Palgin |
NK
|
targets |
|
|
TNFSF10 |
TRAIL (human,
mouse,
chicken,
zebrafish) |
induce/(-)
|
induce |
L |
1 |
3q26 |
TRAIL-R, TRAIL-R2, DcR1,2 |
|
3D,LBD/TRAIL |
NF-kB,
FKHRL1,
FKHR,
Egr1,
IRF1,
Nur77 |
TNFa,
TRAIL,
IFNg,
LPS,
Bm,
Ld,
Lm,
Mt,
Tc, Tg,
St,
influenza
virus, VLP,
IFNa/b,
IFNg,
IL2, IL15,
IL7,
RANKL,
RA,
CD30,
VEGF,
PMA,
TCR/CD3/28,
CD59,
ConA,
Subst.P,
UV,
hypoxia,IL5,
PTEN,
TRIF,
tax,
estradiol,
LiCl |
preDC
|
targets |
|
|
LTB (3) |
lymphotoxin b, TNF-C (human,
mouse,
woodchuck,
pig) |
promote
|
induce |
L |
1 |
6p21.3 |
LTbR |
LT, TNF
|
|
NF-kB,
Egr-1, Ets, Mad1,
c-Myc |
IL4,
TSST-1,
SEB, IFNb,
TNFa,
PMA,
Subst.P,
LPS,
D3
|
B, T, DC
|
p65/S526 |
|
|
LTA (1) |
lymphotoxin a, TNFb (human,
mouse,rat,
rabbit,
woodchuck,
) |
promote
|
induce |
L |
1,2 |
6p21.3 |
HVEM, LTR, TNFR |
LT, LGALS2
|
3D(LRcomplex) |
|
IL2,
IL4,
IL7,
RANKL,
TCR/CD3,ConA,
LPS,
IL15,
VLP
|
preB
|
|
|
|
TNFSF5 |
CD40L, TCA-gp39, XHM, IMD3, CD154 (human,
mouse,
At,marmoset,
Macaca,
rat,cat,
bovine,
pig,
chick) |
inhibit
|
induce |
L |
1,2 |
Xq26 |
CD40 |
|
3D |
NF-kB,
NF-AT,
NFATx,
AP1,
AKNA |
CD28/B7,
IFNg,
IL1,
IL2,
IL13,
Subst.P,
LPS,
Ld,
Lm,
Mt,
Tg,
St,
PTB,
cAMP |
T
|
B, CD30,
IgCgamma1,
NF-AT |
|
|
TNFSF8 |
CD30L, CD153(human,
mouse) |
|
induce |
1
|
1 |
9q33 |
CD30 |
|
|
|
PMA,
Subst.P,
LPS,
Mt,
estrogen |
T
|
T |
|
|
TNFSF7 |
CD70, CD27L (human,
mouse) |
|
induce |
|
1 |
19p13 |
CD27 |
|
|
|
APC,
IL1a, IL12, IL4,
TNFa, RANKL,
BAFF,
CD3/28,
LPS,
Lm,
Sm, Nef,
VLP |
preB
|
txT |
|
|
TNFSF4 |
OX40L, gp34(human,mouse,rat,
rabbit) |
|
induce |
L |
1 |
1q25 |
OX40 |
|
|
GR |
g-irrad.,
TCR/CD3,
SCF,
LPS,
CSBG,
Isoproterenol,TCDD |
T, NK
|
|
|
|
TNFSF9 |
4-1BBL(human,
mouse) |
inhibit/induce
|
induce |
L |
1 |
19p13.3 |
4-1BB |
|
|
E2F1,
ARNT2,
AIRE |
TCR,
RANKL,
ConA,IL1b,
LPS,
MDP,
Lm,
VLP,
PMA/Io,
Wnt-1,
RA |
preB
|
periT |
|
|
TNFSF11 |
RANKL,
TRANCE,
ODF, OPGL (human,
mouse,
rat) |
induce
|
induce |
1 |
1 |
13q14 |
RANK, OPG |
|
L |
D3R,
CREB,
Cbfa1,
STATs |
IL1a,
IL6,
IL7,
OSM,
TCR,
CD40,
IFNb,
TGFb,
M-CSF,
PTH,
prolactin,
IGF-I,
CpG,
GGT,
PKA,
SOCSs,
Jak2 |
lymphonode
|
targets |
|
|
TNFSF15 |
TL1,
VEGI
(human),
TL1A (mouse) |
induce
|
induce
|
|
1 |
9q33 |
DR3, DcR3 |
|
|
|
IL1
|
|
|
|
|
TNFSF12 |
TWEAK,
Apo3L(human,
mouse) |
(induce)
|
induce |
|
1 |
17p13.3 |
DR3, TweakR |
|
|
PPARa |
IFNg,
LPS,
HIV
Vpr, estrogen
|
B, preDC
|
|
|
|
TNFSF14 |
LIGHT,
HVEM-L(human,
mouse) |
induce/inhibit
|
induce |
|
L |
16p11.2 |
HVEM,
LTR,
DcR3 |
|
|
NF-AT,
Sp1,
Ets1 |
MeDNA,
Bm,
Ca2+, calcineurin,
CsA,
TCDD |
preB
|
|
|
|
TNFSF13 |
APRIL,
TRDL-1
(human
a, b,
g,
mouse) |
induce/
inhibit
|
induce |
L |
1 |
17p13.3 |
Fas,
HVEM,TACI, APRIL |
|
|
|
TNFa,
PMA
|
APCs
|
Class
switching |
|
|
TNFSF13B, 20 |
BAFF,
BLyS,
THANK,
TALL-1
(human,
mouse) |
|
induce |
L |
1 |
13q32-q34 |
TACI,
BCMA, BAFF-R,
APRIL
|
|
1,
/w
BAFF-R |
|
PMA,
Expi,
estrogen,
GR
|
|
B, targets |
|
|
TNFSF18 |
TL6,
AITRL, GITRL (human) |
|
induce |
1
|
1 |
1q23 |
AITR |
|
|
|
CD3/CD28,
PMA |
|
|
|
|
ED1 |
EDA(human),
Tabby (mouse) |
(-)
|
(induce) |
Tabby |
(1),
2
|
Xq12-q13.1 |
EDAR |
|
|
Sp1 |
|
|
tarrgets |
|
|
|
Tag7(mouse,truncated),
see PGRP-S |
induce
|
|
Sp |
|
|
|
|
no homology |
|
|
|
|
|
|
Eiger |
Eiger
(Dm) |
induce
|
|
|
|
|
Wengen |
|
|
|
|
|
|
Copyright by Naohiro
Inohara, Department of Pathology, University of of Michigan
Medical School
