Copyright by Naohiro
Inohara, Department of Pathology, University of of Michigan
Medical School| Index | Caspase | CARD/DED/BIR | Bcl-2 | DD | TNF/TNFR | Kinases | ILs | Viral | Lipid | Engulf | TF | RING | Toll | Other Apop | Other NFkB | Alphabet |
Caspases (C14) & Related Cysteine Proteases
Online references
Nunez, G., Benedict, M.A., Hu, Y., Inohara, N. "Caspases: The proteases of the apoptotic pathway." Oncogene 1998 Dec 24;17(25):3237-45 <<<direct download the PDF file from the publisher's site>>>
Review
by Thornberry & Lazebnik (Science 1998)
Review
by Cryns & Yuan (Genes Dev. 1998) containing recent
list (incovinient) of substrates
Review
by Cohen GM(Biochem J 1997) containing old list (covinient)
of
substrates
Human
ICE/CED-3 protease nomenclature
Review by Salvesen
& Dixit (Cell 1997), Wolf
& Green (JBC 1999), Wang
et al. (1999), Earnshaw
et al. (1999)
Caspase activation: The induced-proximity model by Salvesen
GS, Dixit VM (Proc.Natl.Acad.Sci USA 1999)
Review: caspases in development by Los,
Wesselborg, Schulze-Osthoff (Immunity 1999)
Links
List
of Caspases in MEROPS
peptidase database
"Caspase Gallery"
by Gáspár Jékely
"Caspases.com" :)
Calpain & associated proteins (under
construction)
| Group | CPN | Other name | apoptosis | KO | locus | domain structure | 3D | binding protein | regulators | expression |
memo |
| C2(L) | 1 | mu-Calpain, Calpain 1 (human, mosue, rat, bovine, chicken, Xl, zebrafish, Dm, Ce, At) | mediate/ inhibit | 1 | 11q13 | C2/Cal-III/EF1x5 | 30K | b-Ad., hypoxia, HIV Vpr | ubiquitous (highest in epidermis) |
||
| 2 | miliM-Calpain, Calpain 2 (human, mouse, rat) | mediate/ inhibit | 1q41-q42 | C2/Cal-III/EF1x5 | L | 30K | CD40, RANKL, Ma, PMA, b-Ad., ALK1,, PTH | ubiquitous (highest in
epithelium, NK, T, B, APCs) |
|||
| 3 | Calpain 3, p94 (human, mouse, rat, bovine) | 1, LGMD2A | 15q15.1-q21.1 | NS/C2/Cal-III/EF1x5 | 1 | titin | GH, | brain, spinal chord (not
muscle-specific) |
|||
| 5 | hTRA-3, Calpain 5 (human, mouse, rat) | 1 | 11q14 | C2/Cal-III/Tra-3 | Stat4, phenytoin, ErbB4 | ubiquitous | |||||
| 6 | Calpain 6 (human, mouse, rat) | Xq23 | C2/Cal-III/Tra-3 | A2aR, TRRAP, Hoxd10 | placenta |
||||||
| 7 | Calpain 7, PalBH (human, mouse) | 3p24 | C2/PBH/Cal-III | ubiquitous | |||||||
| 8 | nCL-2, nCL-2', Calpain 8 (human, mouse, rat) | 1q32-41 | ubiquitous | ||||||||
| 9 | nCL-4, Calpain 9 (human, mouse) | 1q42.11-q42.3 | C2/Cal-III/EF1x5 | Cdx2,
b-catenin |
stomach | ||||||
| 10 | Calpain 10 (human, mouse, rat) | 2q37.3 | C2/Cal-IIIx2 | ubiquitous | |||||||
| 11 | Calpain 11 (human) | 6p12 | NS/C2/Cal-III/EF1x5 | ubiquitous (not testis- specific) | |||||||
| 12 | Calpain 12 (mouse) | 19q13.2 |
B, NK, T |
||||||||
| 13 | Calpain 13 (human) | 2p22-p21 | |||||||||
| 14 | Calpain 14 (human) | 2 | |||||||||
| SOLH (human) | 16p13.3 | ZF/C2/Cal-III/SOH | NK |
||||||||
| 30K(S) | 30K, CAPNS1, calpain 4 (human, mouse, rat, pig,bovine, chicken) | L | 19q13.1 | G-rich/EF1x5 | GM-CSF | ubiquitous | |||||
| C2 inhibitor | calpastatin, CAST (human) | 5q14-q22 | CalpIx3 | CLPN1,2, 9 | ubiquitous (highest in digits) |
Metalloproteinasess (under
construction)
| Group | Other name | apoptosis | KO | locus | domain structure | 3D | binding protein | substrates | upstream regulators | memo |
| MMP | MMP1, collagenase (human, mouse a & b, rat, rabbit, bovine, horse) | 11q22.3 | PGB /ZnMc(M10/FNx3)/HX x4 | 1 | collagens | PPARg, Bcl3, Fos, HEX, MAZ, TNFa, IL1, IFNa, MIF, VEGF, OSM, PMA, TGFb, PGN, Bm, Hp, Ld, Lm, Mt, Tg, HHV8, SMRT, Erk1/2, p38, IL17, b-cat, TCF4, NO, TGFb1, 15d-PGJ(2), EB(LMP1, Zta ), CITED2, LDL-IC | ||||
| MMP2, collagenase IV, gelatinase A (human, mouse, rat, bovine, rabbit, chicken) | L | 16q13-q21 | ZnMc/HX x4 | L | MCP3, TIMP2 | collagens, MCP3 | NF-kB, AP1, HOXD3, HMG-I, GATA2, Snail, IL1, IL8, IL10, IL12, IL18, osteopontin, SPARC, Subst.P, IGFBP2, LPS, VEGF, TGFa, MIF, hypoxia, mechanical stretch, K-Ras, estrogen, androgen, NSAIDs | |||
| MMP3, collagenase 3,stromelysin (human, mouse) | 11q22.3 | ZnMc/ HX x4 | 1 | TIMP1 | wide range (OPN,) | Fos, Ets2, TEL, IL1b, TNFa, MIF, FGFs, VEGF, MDP, CSBG, irrad, Erk1/2, p38, p21, IL17, D3, ciprofloxacin | ||||
| MMP7, matrilysin, PUMP1 (human, mouse, rat) |
|
L | 11q21-q22 | ZnMc | a-defencin, OPN | IL1,
Ma,
Wnt3a,
FKHR,
EP4 |
||||
| MMP8, collagenase 1 (human, mouse, rat) | 11q22.3 | ZnMc/HXx4 | L | IL1, PMA, UV, EV71 | ||||||
| MMP9, collagenase IVb, gelatinase B (human, mouse, rat, bovine, dog) |
|
L | 20q11.2-q13.1 | ZnMc/HXx4 | L | TIMP1, TMP3 | NF-kB , IRF1, Ets, LXR, PPARb, Pax6, AP1, AP2a, CIITA, TNFa, IL1, IL8, IFNa/b, IFNg, EDA, LPS, Hp, Pg, Mt, PMA, PKCzeta, PDGF, G-CSF, GM-CSF, TGFa, MIF, TN-C, TSP-1, RA, urokinase, HBV, Erk1/2, RO, DEX, Pb, PGE2, PPARa, p38, hypoxia, cepharanthine | |||
| MMP10 (human, mouse, rat) | 11q22.3 | IL1, TNF, UVB, FKHR, Akt, endostatin | ||||||||
| MMP11, stromelysin 3 (human, mouse, rat) | 22q11.23 | ZnMc/HXx4 | Ma, insulin, IGF-II, UVA | |||||||
| MMP12, metalloelastase, MME (human, mouse, rat) | 11q22.3 | ZnMc/HXx4 | 1 | NRF2, IL1, GM-CSF, CSBG | ||||||
| MMP13, collagenase 3 (human, mouse, horse, bovine, Xl) | 11q22.3 | ZnMc/HXx4 | L | IL1,
IL17,
FGFs,
IGF1,
OP-1,
PTH,
MIP3, MDP,
LTA,
Lm, Pg, LLO,
TIAR,
MIF,
Ets2,
AP1,
Cbfa1,
fibronectin,
PGE2,
CITED2,
c-Maf,
androgen |
||||||
| MMP14, MT1-MMP (human, mouse, rat, bovine) | 1 | 14q11-q12 | ZnMc/HXx4/TM | TIMP2, TIMP3 | ALK1, Subst.P, GM-CSF, FGF1, IL10, LPS, Ma, Mt, HOXD10 | |||||
| MMP15, MT2-MMP (human, mouse) | 16q13-q21 | ZnMc/HXx4/TM | TIMP2 | CD8/28,
CD43 |
||||||
| MMP16, MT3-MMP (human, mouse, rat) | 8q21 | ZnMc/HXx4/TM | TIMP2 | E2F1, PTH, LMP1 | ||||||
| MMP17, MT4-MMP (human) | 12q24.3 | ZnMc/HXx4/(GPI) | TIMP2 | TNFa | UVB | |||||
| MMP19, RASI-1 (human, mouse) | 1 |
12q14 | ZnMc/HXx4 | RANTES | ||||||
| MMP20, enamelysin (human, mouse, bovine, pig) | 1 | 11q22.3 | ZnMc/HXx4 | |||||||
| MMP21 (human, mouse) | 10q26.2 | ZnMc;Vn/HXx4 | ||||||||
| MMP23A (human, mouse, rat) | 1p36.3 | ZnMc/ShKT/IG | ||||||||
| MMP23B (human) | 1p36.3 | ZnMc/ShKT/IG | ||||||||
| MMP24, MT5-MMP (human, mouse, rat) | 1 | 20q11.2 | ZnMc/HXx4/TM | |||||||
| MMP25, MT6-MMP (human, rat) | 16p13.3 | ZnMc/HXx4/(GPI) | ||||||||
| MMP26, endometase (human) | 11p15 | ZnMc | Mt, CD9 | |||||||
| MMP27 (human, rat) | 11q24 | ZnMc/HXx4 | ||||||||
| MMP28, epilysin (human, mouse) | 17q11-q21.1 | ZnMc/HXx4 | ||||||||
| viral MMP | ||||||||||
| ADAM | ADAM7 (human) | 8p21.1 | integrin a5b1 | BMPs | ||||||
| ADAM8, CD156a (human) | 1 | 10q26.3 | CD23 | TNFa,
LPS,
Sm |
B, T, NK, APCs |
|||||
| ADAM2, fertilin (human) | 8p11.2 | testis |
||||||||
| ADAM9, MDC9 (human, mouse, rat) | L | 8p11.21 | Reprolysin/disintegrin/ACR/EGF/TM | endophilin-1, SH3PX1 | muscle, epithelial |
|||||
| ADAM18 (human) | 8p11.21 | testis (mouse) |
||||||||
| ADAM10 (human) | L | 15q21.3-q23 | TNFa,
ephrin-A2,
CXCL16 |
Hp, IL5 | B, T, NK, APCs | |||||
| ADAM11 (human) | 17q21.3 | brain |
||||||||
| ADAM12, Meltrin alpha (human) | L | 10q26.3 | Src, Grb2 | IL10/12, Hp, Pg, Sm | placenta (human) |
|||||
| ADAM15, MDC15 (human, mouse, rat) | 1 | 1q21.3 | integrin a5/b3, endophilin-1, SH3PX1, CD23 | IL13,
TGFR1,
ALK1 |
epithelial, blastcysts |
|||||
| TACE, ADAM17, CD156b (human, mouse, rat, zebrafish, Dm, mosquito) | L | 2p25 | Reprolysin/disintegrin/(EGF)/TM | 1 | TNFa, CD30, CD40, IL1RII, TNFR1, IL15R, TNFR2, p75NTR, CX3CL1, Notch, M-CSFR, c-Kit, Fractalkine, VCAM1, MUC1 | PTPH1, PMA, irrrad, p73 | oocyte |
|||
| ADAM19, meltrin-b (human) | 1 | 5q32-q33 | Hoxc8, Notch, Hp | |||||||
| ADAM20 (human) | 14q24.1 | Reprolysin/disintegrin/ACR/TM | ||||||||
| ADAM21 (human) | 14q24.1 | testis (mouse) |
||||||||
| ADAM22, MDC2 (human) | 7q21 | brain |
||||||||
| ADAM23, MDC3 (human) | 2q33 | brain |
||||||||
| ADAM28 (human) | 8p21.1 | CD23 | IL13, ARNT2 | B (human) |
||||||
| ADAM29 (human) | 4q34 | Reprolysin/disintegrin/ACR/EGF/TM | |
testis |
||||||
| ADAM30 (human) | 1p13-p11 | |||||||||
| ADAM32(human) | 20p13 | Reprolysin/disintegrin/ACR(EGF) | testis |
|||||||
| ADAM33 (human) | 20p13 | (TIMP3, TIMP4) | Kit-L, APP | asthama | ||||||
| ADAMTS1 (human, mouse, rat) | L | 21q21.2 | FKHR,
VEGF,
Thrombin,Akt |
|||||||
| ADAMTS5 (human) | 1 |
21q21.3 | ||||||||
| ADAMTS2 (human) | 5qter | uterus, unbilical cord, ovary (mouse) |
||||||||
| ADAMTS3 (human) | 4q13.3 | |||||||||
| ADAMTS4 (human) | 1q21-q23 | aggrecan, ADAMTS4 | b-amyloid, IL1b | |||||||
| ADAMTS7 (human) | 15pter-qter | |||||||||
| ADAMTS8, METH2 (human) | 11q25 | |||||||||
| ADAMTS15 (human) | 11q25 | |||||||||
| ADAMTS9 (human) | 3p14.3-p14.2 | |||||||||
| ADAMTS10 (human) | 19p13.2 | |||||||||
| ADAMTS12 (human) | 5q35 | |||||||||
| ADAMTS13 (human) | 9q34 | |||||||||
| ADAMTS14 (human) | 10q2 | |||||||||
| decysin (human) | 8p12 | disintegrin | ||||||||
| ADAMTSL1, ADAMTSR1, punctin,
thrombospondin |
9p22.2-p22.1 |
RANTES |
||||||||
| TIMP | TIMP1(human, mouse, rat, bovine, pig, sheep, horse, dog, rabbit,), oyster, Dm | inhibit | Xp11.3-p11.23 | TIMP | MMP3, 9 | LPS, Hp, Ma, Ld, Lm, Pg, Sm, Mt, Tg, HHV8, Egr1, STAT3, LMP1, IL1, IL10, IL12, IL13, M-CSF, AgII, PTH, TGFb1, IGFBP2, HOXD10, UVB, UVC, PG-A2, heat shock, PGE2, c-Myc, RUNX1, RUNX2, staurosporine | targets |
|||
| TIMP2 (human, mouse, rat, G.pig, rabbit, dog, bovine, pig, chick,) | 1 | 17q25 | MMP14-17,33 | B-Myb, HEX, IL4, CNTF, LPS, HOXD10, p38, DAC/TSA, c-Myc | ||||||
| TIMP3(human, mouse, rat, rabbit, horse, bovine, chick, Xl, catshark) | induce | L | 22q12.3 | TIMP | MMP9, 14, (TACE), 33 | A-Myb,
B-Myb,
FKHR,
AP1,
HEX,
TNFa,
LPS,
IRF3,
DAC/TSA,
irrad,
heat
shock, TGFb1,
methylation,
IL1 |
||||
| TIMP4(human, mouse, rat, rabbit, bovine,) | 3p25 | MDP | ||||||||
| ACE | see ACE |
On-line reviews
MMPs by Sternlicht & Werb (Annu Rev Cell Dev Biol 2001)
Copyright by Naohiro
Inohara, Department of Pathology, University of of Michigan
Medical School| HOME | All-in-One Seq Analyzer |