TLRs, related protein and non-lectin/Ig type pathgen recognizing proteins (Nod family is here)
 

Group

Protein

Species

apoptosis

NF-kB act.

Binding Partner

Structure

KO

gene

locus

regulators

3D

memo

TLR

Toll

D.m.,D.p.,D.s., S.a., A.g.

induce

Tube, MyD88

LRR/TM/TIR

1

1

LPS, IL13, PMA

TIR

anti-fungal

TLR1

human, mouse, sea urchin

(BLP)

LRR/TM/TIR

L

4p14

IFNg, influenza A, Sendai, Hp

TIR

anti-bacterial

TLR2

human, Mf, mouse, bovine, chTLR2(chick), sea urchin

mediate

induce

MD2, SP-A, zymosan, PGN, (L TA, BLP, LPS(?), porins, glycolipid, hsp70, hsp60), TRIF, MyD88, TRIAD3

LRR/TM/TIR

L

1,2,3

4q32

NF-kB, STAT5, Sp1, Sp3, TLR4, LPS (-), PGN, LTA, Lm, TNFa, Fas, IFNa, IFNg, DEX, GCSF, TCR, PMA, Ec, Sa, influenza A, Sendai

TIR, TIR(P681h)

anti-bacterial

TLR3

human, mouse, bovine,

(induce?)

(dsRNA, mRNA), TRIF, TRIAD3

LRR/TM/TIR

1

4q35

TRAIL, IFNa/b, IFNg, STAT1, LPS, LTA, dsRNA, B-DNA, Ec, Lm, Sa,  LLO, PMA, IFNAR1, TRIF

anti-viral

TLR4

human, mouse, rat, bovine, dog, cat, chimpanzee, horsebaboon

induce

induce

(LPS, sHA, hsp70, hsp60, heparan sulfate proteoglycan), CD14, MD2, MyD88, TLR5, BTK, JIP3, TRIAD3, NAD(P)H oxidase

LRR/TM/TIR

L, d

1, m

9q32-q33

PU.1, AP1, MIF, TNFa, IFNa, IFNg, LPS, LTA, Lm,  hypoxia, Oxidant stress, PMA, estrogen, influenza A, Sendai, MIF

anti-Gram negative

TLR5

human, mouse, trout

flagellin, TLR4, TRIAD3

LRR/TM/TIR

1

1q41-q42

Ec, Hp, Lm, Sa, flagellin

anti-bacterial

TLR6

human, mouse

(BLP), BTK

LRR/TM/TIR

1

1

4p15.1

PMA, Fas, LPS, LTA, Hp

anti-bacterial

TLR7

human, mouse

(ssRNA, imidazoquinolines, R-848, CpG)

LRR/TM/TIR

Xp22.3

IFNa,  IFNg, LPS, LTA, Ec, Sa, influenza A, Sendai, PMA, MeDNA

anti-viral

TLR8

human, mouse

(R-848)

LRR/TM/TIR

Xp22

LPS, PMA

TLR9, CpG1

human, mouse, pig, cat, dog, bovine,

(DNA,CpG), Ras, BTK, TRIAD3

LRR/TM/TIR

L

3p21.3

CSF1, IgG, MeDNA

anti-bacterial

TLR10

human

LRR/TM/TIR

1

4p14

IgG

TLR11

mouse

induce

LRR/TM/TIR

uropathogenic bacteria

TLR12

mouse

LRR/TM/TIR

TLR13

mouse

LRR/TM/TIR

SIGIRR/TIR8

human, mouse

inhibit

LRR/TM/TIR

L

11p15.5

18 wheeler

D.m., Bm

LRR/TM/TIR

1

1

2R 56F7-56F8

anti-bacterial

Toll5/Tehao

D.m., D.s.

LRR/TM/TIR

1

Toll7/Tollo/Tak1

D.m.

LRR/TM/TIR

1

Toll4/CG18241

D.m.

LRR/TM/TIR

1

2L

Toll6/CG7250

D.m.

LRR/TM/TIR

1

3L

CG5528

D.m.

LRR/TM/TIR

1

3L

Toll7/CG8595

D.m.

LRR/TM/TIR

1

2R

Toll3/DmMstProx

D.m.

LRR/TM/TIR

1

Toll-related (under construction)

grasshopper, mosquito (1, 2, 3, 6, Trex, Toll9),G.p.p.

TIR(partial)

Tol-1

C.e.

LRR/TM/TIR

1

1

I

RP105, CD180

LY64 (human), RP105(mouse)

supress

MD1

LRR/TM

5q12

AIRE, PMA, Ec, Hp, Sa

Synleurin

human

LRR/TM

5q12

Adaptors

MyD88

human (S), mouse, frog, D.m.

induce

induce

IRAK,IRAK-2, IRAK-M, IL-1R, FADD, MAL

DD/TIR

L

1,2p21.3

3p21.3

IL-6, IRF1, STAT3, STAT5, IFNa/b, IFNg, IL6, IL15, IL21, TNFa, TRAIL, M-CSF, MDP, Ec, Hi, Mt, Sa, Ye, Yp, LPS, PMA, TCDD; TGFb

Ub

Tube

D.m.

induce

Pelle, Toll, Cactus

DD

1

1

Tube/Pelle DD

TIRAP, MAL

human, mouse

induce

TLR4/MD2, MyD88, IRAK2, MAL

/TIR

L

1

11q24.2

LPS

TRIF, TICAM1, LPS2

human, mouse

induce

induce

TLR2, TLR3, IRF3, RIP, RIP3

/TIR/RHIM

L

19p13.3

NF-kB, TNFa, IL1, IFNb, PAMPs, Hoxd10

for TLR3, 4, targets

TIRP, TRAM, TICAM2

human, mouse

induce

TLR4, TRIF, IL1R, IRAKs, TRAF6

TIR

1

5q23.1

SARM, TIR-1 (Ce), CG7915 (Dm)

human, mouse, rat, Ce, Dm, Ag,

ARMs/SAMx2/TIR

17q11

Tollip

human, mouse, C.e.

(inhibit)

Tom1, IRAK, IL1R

C2//CUE

1

11p15.5

VLP

Ubiquitination

Pellino (Pli)

Dm, Ce

Pelle

Pellino 1(human, mouse)

mediate

IRAK, IRAK4, TRAF6

2p13.3

LPS, TRIF

Pellino 2(human, mouse)

IRAK, IRAK4, Bcl10

14q21

AP1

RNA helicase

MDA5, HELICARD

human, mouse,

( IRF3)

induce

(polyIC)

CARD/AAA/helicase

L

2p24.3-q24.3

IFNb, mezerein, B-DNA

casp, B, T, APCs

RIG-I, DDX58

human, mouse, bovine, pig, chicken, fugu,

induce (also IRF3)

induce

CARD/AAA/helicase

L

9p12

IFNb

VISA, IPS1, MAVS, CARDIF

human, mouse, rat,

induce

CARD/TM

L

NS3/4A

Kinase

IRAKs

for IRAK family, see kinase

ligand?

SPAETZLE

D.m.

Toll

NGF

1

1

fungi inf.

HMGB1

human

induce

HMG

1

PGRP

PGRP-Ialpha, PGLYRP3

human, mouse, rat

PGN

ami2x2

1q21

esophagus, fetal liver

PGRP-Ibeta, PGLYRP4

human, mouse

PGN

ami2x2

1q21

esophagus

PGRP-S, tag7, PGLYRP, PGLYRP1

human, mouse, rat, bovine

PGN

ami2

1

19q13.2-q13.3

TCR, Hf, Hp

bone marrow

PGRP-L, PGLYRP2

human, mouse, pig

PGN

?/ami2

19p13.13

liver

PGRP

D.m. (SA, SB1, SB2, SC1, SC2, SD)

PGN

ami2

mediate Toll pathway

PGRP related

phage lysozyme,[T7, T3, fYe03-12] bacterial[M.t., S.c., Cg, ]

PGN

ami2

KAmt, w/RNApol, LB

Lysozyme

LYZ

lysozyme, LYZ (human, mouse M, P, rat)

lysozyme

12q14.3

MEF, GABP, RA, LPS, Sp, HCV, NRF2, TNF, TRAF2/TRAF5

APCs

LYZL6, LOC57151 (human)

lysozyme

17q11.2

testis

SPACA3, LYC3, LYZL3, SLLP1, ALLP17 (human)

lysozyme

17q11.2

testis

LYZL4, LYC4 (human)

lysozyme

3p22.1

testis

LYZL1, LYC2,  MGC33408 (human)

lysozyme

10p11.23

testis

LYZL2  (human)

lysozyme

10p11.23

testis

PNPK6288, LOC389852 (human)

lysozyme

Xp11.23

testis, skin

lactalbumin alpha, LALBA (human)

lysozyme

12q13

mammary gland

SLT

LYG1, LOC129530, SALW1939, Lysozyme G (human, mouse, chicken, Xl, zebrafish, Ec)

SLT

2q11.2

tongue

LYG2,  LYGH (human, mouse)

SLT

2q11.2

Other

CD14

CD14 (human, mouse, rat, horse, bovine, rabbit)

mediate

mediate

LPS, PGN

LRR-GPI

L, d

1

5q31.1

AP-1, AIRE, Sp1, MEF2D, PPARg, IFNg, PMA, TGFb1, IL13, LPS, Pg, Hf, C/EBPs, estrogen, PGE2, PMA, cAMP, ethanol

1

anti-bacterial, APCs

ML

MD2 (human, mouse, C. hamster, bovine)

TLR4, LPS, LTA, TLR2, MD2

ML

1

1,2

8q13.2

IFNg, SOCS3, PMA

APCs

MD1, Ly86 (human, mouse)

RP105, (LPS)

ML

1

1,2

6p24.1

Myb, PMA, Tc

APCs, B

Npc2, HE2 (human)

cholesterol

ML

npc

14q24.3

AIRE

1

ubiquitous, highest in APCs

GM2A (human)

GM2

ML

1

5q31.3-q33.1

1

placenta, bronchia, preB

LBP

LBP (human, mouse, rat)

LPS, PGN

LBP

L

20q11.23-q12

NRF2, RA, A2aR, Pg, Hp

liver

BPI (human, rabbit, bovine, Ce, At)

LBP

20q11.23-q12

Hp

1

neutrophil

BPIL1, RYSR, LPLUNC2 (human)

LBP

20q11.22

airway

BPIL3, LPLUNC6 (human)

20q11.22

alfactory epithelium

BPIL2 (human)

LBP

22q12.3

epidermis, digits

PLTP, LTP2 (human, mouse, rabbit, pig,)

LBP

1

20q12-q13.1

LXR, FXR, hypoxia, bile acid, fenofibrate, ErbB4

epidermis

LPLUNC1, C20orf114 (human)

20q11.1

airway

RYA3, LPLUNC3, dJ726C3.4、C20orf185 (human)

LBP

20q11.21

RY2G5, LPLUNC4, dJ726C3.5, C20orf186 (human)

LBP

20q11.21

CETP (human, rabbit)

LBP

16q21

lymph node, placenta, liver

Mindin

Spondin 2, M-spondin, Mindin, SPON2 (human, mouse)

FS/TSP1

1

4p16.3

NK

spondin 1, F-spondin, SPON1 (human, mouse)

FS/TSP1x6

11p15.2

CCF

earthworms,  CG6895-PA(Dm)

beta 1,3-glucanase

BRICHOS

SP-C, PSP-C, SFTP2, SP5, SFTPC (human, mouse, rat)

CD14, LPS

BRICHOS

L

8p21

TTF1, GATA6, TAZ

lung

LECT1, CHM1, CHM-I, BRICD3, Chondromodulin (human, mouse, rabbit, chicken, zebrafish)

BRICHOS

L

13q14-q21

Sp3, TGFb, FGF2, PTHRP

ITM2B, BRI, FBD, ABRI, BRI2, E25B, E3-16, BRICD2B (human, mouse, Ce, zebrafish)

BRICHOS

dmt

13q14.3

ITM2A, E25A, BRICD2A (human, mouse)

BRICHOS

Xq13.3-Xq21.2

tenomodulin, TNMD (human, mouse, rat,

BRICHOS

Xq21.33-q23

BRI3, E25, Itm2c (human, mouse, chicken)

BRICHOS

2q37

APCs

GDDR (human)

BRICHOS

2p13.3

AMP18 (human)

BRICHOS

2p13.2

albumin

albumin, ALB (human)

PG

albumin x3

4q11-q13

C/EBPa, NF-IL6, HNF1, AP1, p53, HGF, HB-EGF, TNFa, DEX, H-Ras

Liver

alpha-fetoprotein, AFP (human)