Toll related proteins

Index

Caspase

CARD/DED/BIR

Bcl-2

TNF/TNFR

Kinases

ILs

Viral

Lipid

Engulf

RING

Toll

Other Apop

Other NFkB

Alphabet

Proteins for Immunity

TLRs, related protein and non-lectin/Ig type pathgen recognizing proteins (Nod family is here)

Group Protein Species apoptosis NF-kB act. Binding Partner Structure KO gene locus regulators 3D memo

TLR

Toll D.m.,D.p.,D.s., S.a., A.g.
induce Tube, MyD88 LRR/TM/TIR 1 1
LPS, IL13, PMA TIR anti-fungal

TLR1 human, mouse, sea urchin
(BLP) LRR/TM/TIR L
4p14 IFNg, influenza A, Sendai, Hp TIR anti-bacterial

TLR2 human, Mf, mouse, bovine, chTLR2(chick), sea urchin mediate induce MD2, SP-A, zymosan, PGN, (L TA, BLP, LPS(?), porins, glycolipid, hsp70, hsp60), TRIF, MyD88, TRIAD3
LRR/TM/TIR L 1,2,3 4q32 NF-kB, STAT5, Sp1, Sp3, TLR4, LPS (-), PGN, LTA, Lm, TNFa, Fas, IFNa, IFNg, DEX, GCSF, TCR, PMA, Ec, Sa, influenza A, Sendai TIR, TIR(P681h) anti-bacterial

TLR3 human, mouse, bovine, (induce?) (dsRNA, mRNA), TRIF, TRIAD3
LRR/TM/TIR 1
4q35 TRAIL, IFNa/b, IFNg, STAT1, LPS, LTA, dsRNA, B-DNA, Ec, Lm, Sa, LLO, PMA, IFNAR1, TRIF
anti-viral

TLR4 human, mouse, rat, bovine, dog, cat, chimpanzee, horse baboon induce induce (LPS, sHA, hsp70, hsp60, heparan sulfate proteoglycan), CD14, MD2, MyD88, TLR5, BTK, JIP3, TRIAD3, NAD(P)H oxidase
LRR/TM/TIR L, d 1, m 9q32-q33 PU.1, AP1, MIF, TNFa, IFNa, IFNg, LPS, LTA, Lm, hypoxia, Oxidant stress, PMA, estrogen, influenza A, Sendai, MIF
anti-Gram negative

TLR5 human, mouse, trout

flagellin, TLR4, TRIAD3
LRR/TM/TIR
1 1q41-q42 Ec, Hp, Lm, Sa, flagellin
anti-bacterial

TLR6 human, mouse

(BLP), BTK LRR/TM/TIR 1 1 4p15.1 PMA, Fas, LPS, LTA, Hp
anti-bacterial

TLR7 human, mouse

(ssRNA, imidazoquinolines, R-848, CpG) LRR/TM/TIR

Xp22.3 IFNa, IFNg, LPS, LTA, Ec, Sa, influenza A, Sendai, PMA, MeDNA
anti-viral

TLR8 human, mouse

(R-848) LRR/TM/TIR

Xp22 LPS, PMA

TLR9, CpG1 human, mouse, pig, cat, dog, bovine,

(DNA,CpG), Ras, BTK, TRIAD3
LRR/TM/TIR L
3p21.3 CSF1, IgG, MeDNA
anti-bacterial

TLR10 human

LRR/TM/TIR
1 4p14 IgG

TLR11 mouse
induce
LRR/TM/TIR

uropathogenic bacteria

TLR12 mouse

LRR/TM/TIR

TLR13 mouse

LRR/TM/TIR

SIGIRR/TIR8 human, mouse
inhibit
LRR/TM/TIR L
11p15.5

18 wheeler D.m., Bm

LRR/TM/TIR 1 1 2R 56F7-56F8

anti-bacterial

Toll5/Tehao D.m., D.s.

LRR/TM/TIR
1

Toll7/Tollo/Tak1 D.m.

LRR/TM/TIR
1

Toll4/CG18241 D.m.

LRR/TM/TIR
1 2L

Toll6/CG7250 D.m.

LRR/TM/TIR
1 3L

CG5528 D.m.

LRR/TM/TIR
1 3L

Toll7/CG8595 D.m.

LRR/TM/TIR
1 2R

Toll3/DmMstProx D.m.

LRR/TM/TIR
1

Toll-related (under construction) grasshopper, mosquito (1, 2, 3, 6, Trex, Toll9),G.p.p.

TIR(partial)

Tol-1 C.e.

LRR/TM/TIR 1 1 I

RP105, CD180 LY64 (human), RP105(mouse) supress
MD1 LRR/TM

5q12 AIRE, PMA, Ec, Hp, Sa

Synleurin human

LRR/TM

5q12

Adaptors

MyD88 human (S), mouse, frog, D.m. induce induce IRAK,IRAK-2, IRAK-M, IL-1R, FADD, MAL DD/TIR L 1,2p21.3 3p21.3 IL-6, IRF1, STAT3, STAT5, IFNa/b, IFNg, IL6, IL15, IL21, TNFa, TRAIL, M-CSF, MDP, Ec, Hi, Mt, Sa, Ye, Yp, LPS, PMA, TCDD; TGFb

Ub

Tube D.m.
induce Pelle, Toll, Cactus DD 1 1

Tube/Pelle DD

TIRAP, MAL human, mouse
induce TLR4/MD2, MyD88, IRAK2, MAL /TIR L 1 11q24.2 LPS

TRIF, TICAM1, LPS2 human, mouse induce induce TLR2, TLR3, IRF3, RIP, RIP3
/TIR/RHIM L
19p13.3 NF-kB, TNFa, IL1, IFNb, PAMPs, Hoxd10
for TLR3, 4, targets

TIRP, TRAM, TICAM2 human, mouse
induce TLR4, TRIF, IL1R, IRAKs, TRAF6 TIR 1
5q23.1

SARM, TIR-1 (Ce), CG7915 (Dm)
human, mouse, rat, Ce, Dm, Ag,

ARMs/SAMx2/TIR

17q11

Tollip human, mouse, C.e.
(inhibit) Tom1, IRAK, IL1R
C2//CUE
1 11p15.5 VLP

Ubiquitination

Pellino (Pli)
Dm, Ce

Pelle

Pellino 1(human, mouse)
mediate IRAK, IRAK4, TRAF6

2p13.3 LPS, TRIF

Pellino 2(human, mouse)

IRAK, IRAK4, Bcl10

14q21 AP1

RNA helicase

MDA5, HELICARD
human, mouse,
( IRF3)
induce
(polyIC)
CARD/AAA/helicase
L

2p24.3-q24.3
IFNb, mezerein, B-DNA
casp, B, T, APCs

RIG-I, DDX58
human, mouse, bovine, pig, chicken, fugu,
induce (also IRF3)
induce

CARD/AAA/helicase L

9p12
IFNb

VISA, IPS1, MAVS, CARDIF
human, mouse, rat,

induce

CARD/TM L

NS3/4A

Kinase IRAKs for IRAK family, see kinase

ligand? SPAETZLE D.m.
Toll NGF 1 1
fungi inf.

HMGB1 human
induce
HMG 1

PGRP

PGRP-Ialpha, PGLYRP3
human, mouse, rat

PGN ami2x2

1q21

esophagus, fetal liver

PGRP-Ibeta, PGLYRP4
human, mouse

PGN ami2x2

1q21

esophagus

PGRP-S, tag7, PGLYRP, PGLYRP1
human, mouse, rat, bovine

PGN ami2 1
19q13.2-q13.3
TCR, Hf, Hp bone marrow

PGRP-L, PGLYRP2
human, mouse, pig

PGN ?/ami2

19p13.13

liver

PGRP D.m. (SA, SB1, SB2, SC1, SC2, SD)

PGN ami2

mediate Toll pathway

PGRP related phage lysozyme,[T7, T3, fYe03-12] bacterial[M.t., S.c., Cg, ]

PGN ami2

KAmt, w/RNApol, LB

Lysozyme
LYZ

lysozyme, LYZ (human, mouse M, P, rat)

lysozyme

12q14.3 MEF, GABP, RA, LPS, Sp, HCV, NRF2, TNF, TRAF2/TRAF5
APCs

LYZL6, LOC57151 (human)

lysozyme

17q11.2

testis

SPACA3, LYC3, LYZL3, SLLP1, ALLP17 (human)

lysozyme

17q11.2

testis

LYZL4, LYC4 (human)

lysozyme

3p22.1

testis

LYZL1, LYC2, MGC33408 (human)

lysozyme

10p11.23

testis

LYZL2 (human)

lysozyme

10p11.23

testis

PNPK6288, LOC389852 (human)

lysozyme

Xp11.23

testis, skin

lactalbumin alpha, LALBA (human)

lysozyme

12q13

mammary gland

SLT
LYG1, LOC129530, SALW1939, Lysozyme G (human, mouse, chicken, Xl, zebrafish, Ec)

SLT

2q11.2

tongue

LYG2, LYGH (human, mouse)

SLT

2q11.2

Other

CD14 CD14 (human, mouse, rat, horse, bovine, rabbit) mediate mediate LPS, PGN LRR-GPI L, d 1 5q31.1 AP-1, AIRE, Sp1, MEF2D, PPARg, IFNg, PMA, TGFb1, IL13, LPS, Pg, Hf, C/EBPs, estrogen, PGE2, PMA, cAMP, ethanol 1
anti-bacterial, APCs

ML

MD2 (human, mouse, C. hamster, bovine)

TLR4, LPS, LTA, TLR2, MD2 ML 1 1,2 8q13.2 IFNg, SOCS3, PMA
APCs

MD1, Ly86 (human, mouse)

RP105, (LPS) ML 1 1,2 6p24.1 Myb, PMA, Tc
APCs, B

Npc2, HE2 (human)

cholesterol ML npc
14q24.3 AIRE 1 ubiquitous, highest in APCs

GM2A (human)

GM2 ML 1
5q31.3-q33.1
1 placenta, bronchia, preB

LBP

LBP (human, mouse, rat)

LPS, PGN
LBP L
20q11.23-q12 NRF2, RA, A2aR, Pg, Hp
liver

BPI (human, rabbit, bovine, Ce, At)

LBP

20q11.23-q12 Hp 1 neutrophil

BPIL1, RYSR, LPLUNC2 (human)

LBP

20q11.22

airway

BPIL3, LPLUNC6 (human)

20q11.22

alfactory epithelium

BPIL2 (human)

LBP

22q12.3

epidermis, digits

PLTP, LTP2 (human, mouse, rabbit, pig,)

LBP 1

20q12-q13.1 LXR, FXR, hypoxia, bile acid, fenofibrate, ErbB4
epidermis

LPLUNC1, C20orf114 (human)

20q11.1

airway

RYA3, LPLUNC3, dJ726C3.4、C20orf185 (human)

LBP

20q11.21

RY2G5, LPLUNC4, dJ726C3.5, C20orf186 (human)

LBP

20q11.21

CETP (human, rabbit)

LBP

16q21

lymph node, placenta, liver

Mindin

Spondin 2, M-spondin, Mindin, SPON2 (human, mouse)

FS/TSP1 1
4p16.3

NK

spondin 1, F-spondin, SPON1 (human, mouse)

FS/TSP1x6

11p15.2

CCF earthworms, CG6895-PA(Dm)

beta 1,3-glucanase

BRICHOS
SP-C, PSP-C, SFTP2, SP5, SFTPC (human, mouse, rat)

CD14, LPS BRICHOS L
8p21 TTF1, GATA6, TAZ

lung

LECT1, CHM1, CHM-I, BRICD3, Chondromodulin (human, mouse, rabbit, chicken, zebrafish)

BRICHOS L
13q14-q21 Sp3, TGFb, FGF2, PTHRP

ITM2B, BRI, FBD, ABRI, BRI2, E25B, E3-16, BRICD2B (human, mouse, Ce, zebrafish)

BRICHOS dmt
13q14.3

ITM2A, E25A, BRICD2A (human, mouse)

BRICHOS

Xq13.3-Xq21.2

tenomodulin, TNMD (human, mouse, rat,

BRICHOS

Xq21.33-q23

BRI3, E25, Itm2c (human, mouse, chicken)

BRICHOS

2q37

APCs

GDDR (human)

BRICHOS

2p13.3

AMP18 (human)

BRICHOS

2p13.2

albumin albumin, ALB (human)

PG albumin x3

4q11-q13 C/EBPa, NF-IL6, HNF1, AP1, p53, HGF, HB-EGF, TNFa, DEX, H-Ras
Liver

alpha-fetoprotein, AFP (human)

albumin x3

4q11-q13
NF-kB, C/EBPs, FOXA, Nkx2.8, T3R, p53, ATBF1, DEX/GR, HNF1, HNF3, HNF4, AP1, RA/RAR/RXR, TGFb, HGF, 12-PGJ2, osmotic pressure, H-Ras, Raf, Rif, Butyrolactone I

fetal liver

apha-albumin, ALB2, ALBA, AFAMIN (human)

albumin x3

4q11-q13

liver

DBP (human)

albumin x2

4q11-q13

Serpin Serpin27A (Dm)

4q11-q13

mediate Toll pathway

C114 C114, PRKRIP1 (human, mouse, Dm, Ce, Nc)

dsRNA, PKR cc

7q22.1 IL11

Ig-related Proteins

Group Protein Species apoptosis NF-kB act. Binding Partner Structure KO gene locus regulators 3D memo

IgG sup. Ig Kappa (IGKC: ex: human)

2p12 NF-kB, ARNT2, TCR/CD3, PMA, TNFa, IL12, IL15, Hp, VDR

Lambda(IGLC1: ex: human)

22q11.2 TIMP1

heavy (human: const. ex: a1,a2, g1, g2, g3, g4, d, e,)

L
14q32.33 LPS, Hp, Sm, IL10/12, estrogen, IL5, Blimp1, Lyn, ARNT2, TIMP1

TREM1 TREM1(human, mouse) inhibit

DAP12 IG/TM

6p21.1 LPS, fungi
APCs

TREM2 (human)

DAP12
IG/TM 1

6p21.1

TLT1 (human)

IG/TM

6p21.1

TREML2, FLJ13693, C6orf76 (human)

IG/TM

6p21.32

RAGE, AGER (human, mouse, rat, bovine)

IGx2/TM

6p21.3 IFNa

DAP12 DAP12, TYROBP (human, b, mouse, pig, cow) inhibit
DAP12, CD94, KIR2DS2, TREM1, TREM2, ZAP70, Syk, NKG2D, NKp44 TM/ITAM L
19q13.1 TCR
NK, DC

DAP10 (human, mouse, pig)

NKG2D, PI3K TM L
19q13.1

B, T

TCR TCRa (ex:human) induce activate antigen, CD3, CD8, SH2s, Lck, TCRb IG/TM(VJC) L
14q11.2 LEF1, TCF1, CREB, HIV1, TNFa, ALK1 1 T

TCRb (ex:human)

antigen, superantigens, CD3, TCRa IG/TM(VJC) 1
7q35 NF-kB,Hp, HCV, 1

TCRg (ex: human)

TCRd IG/TM(VJC)

7p15-p14 TCR, IL3, Mad1

TCRd (ex:human, mouse, rat, sheep, chicken, Xl)

TCRg IG/TM(VJC) 1
14q11.2 T3, IFNa, Notch, PPARa

CD3g (human, mouse, rat, bovine, sheep) induce activate TCR IG/TM/ITAM(AP2) 1
11q23 SDF1, Mad1, Tc, HCV, camptothecin, TIMP1

T, NK

CD3e (human, bovine, sheep, dog, chicken)

TCR
1
11q23 Tc
T

CD3d (human)

TCR IG/TM/ITAM 1
11q23 IFNa
T

CD3zeta, CD3Z (human, mouse,chick)

Syk, ZAP70, NKp46 TM/ITAMx3 1
1q22-q23 O2 stress, PMA, PPARa
NK, T

CD79 CD79A, mb1, Ig-alpha (human, mouse)

Ig/CD5/CD19/CD22/CD79b IG/TM/ITAM 1
19q13.2 Pax5, TIMP1

B

B29, CD79B, Ig-beta (human, rat)

Ig/CD5/CD19/CD22/CD79a IG/TM/ITAM

17q23 EBF, OBF1, GR, c-Myc, UVB, Lyn, TIMP1
B

CD8 CD8alpha, Lyt23 (human, mouse, rat, chick) induce/ inhibit activate MHC-I, Lck IG/TM L
2p12 ,ITM2A, CREB, HIV1, VLP, Ikaros L T, NK, for MHC-I

CD8beta, CD8B1 (human, mouse, rat, chick)

Ig/TM 1
2p12 CsA/FK506, IL15, LiCl, MVA
T

CD4 CD4, L3T4 (human,mouse, rat, chick) induce activate MHCII, TCR, LCK IGx3/TM L
12pter-p12 c-Myb, Elf1, Ets1,Ets2, MAZ, ZEB, HES1, TCR, PMA, HHV6, HHV7, HBx
APCs, for MHC-II

IgE Fc R, FceRI IgE Fc R a, FCER1A (human, mouse, rat)

IGx2/TM

1q23 STAT6, IL4, GATA1, Elf1, USFs, GCSF, BMP2 1 APCs

IgE Fc R g, FCER1G(human, mouse, rat)

TM/ITAM 1
1q23 TCR, Tc
APCs, NK

IgG Fc gamma R IgG Fc R 1, FCGR1A, IGFR1, CD64 (human)

high affinity for Fc g, periplakin IGx3/TM L
1q21.2-q21.3 IFNa, IFNg, IL1, LPS, Tc, D3, estrogen

IgG Fc RII, FCGR2A, IGFR2, CD32 (human) inhibit induce low affinity for Fc g IGx2/TM L
1q21-q23 LPS, IL8, IL10, SCF, DEX, hypoxemia
APCs

IgG Fc RIII, FCGR3A, IGFR3, CD16 (human a, b)

low affinity for Fc g IGx2/TM L
1q23 IFNg, IL2, IL3, IL8, HCV, ARNT2, IFNa, staurosporine

NK

Fc alpha R Fc alpha R, IgA Fc R, CD89, FcaR (human)

IGx2

19q13.2-q13.4 C/EBPa, Fas, Elf-1, camptothecin
APCs, Eo

CD7 CD7 (human, mouse) mediate
CD3, CD45, PI3K, IG/TM/YEDM 1
17q25.2-q25.3 Notch, Ca2+, cAMP, IL5

NK, T

CD19 CD19 (human, mouse, pig) mediate/ inhibit mediate CD2, CD9, , CD81, CD225, Lyn, c-Abl, PI3K IGx2/TM L
16p11.2 Pax5, Lyn(P), CD81
B cell, RP105

B7 CD80, CD28LG1, B7-1 (human, mouse, rat) prevent
CD28, CTLA4 IGx2/TM L
3q21 NF-kB, Bcl6, HLX, TCR/CD3, IL1, IL4, IL10, jagged-1, GM-CSF, TNFa, Fas, IFNb, IFNg, Hp, Yp, dsDNA, HIV Vpr, MVA, S-27609, LeIF, triptolide L

CD86, CD28LG2, B7-2 (human, mouse, rat) prevent
CD28, CTLA4, MIR IG/TM L
3q21 NF-kB, ARNT2, BCR, IFNb,IFNg, TNFa/IFNg, CD40L, C4BP, LPS, MDP, S-27609, Hp, Lm, Tc, UDP-Glc, IL-3, IL10, IL18, GM-CSF, jagged-1, Jnk, p38, DEX, D3, PGE2, triptolide, estrogen, camptothecin
APCs

GL50, B7H2, B7RP1, ICOSL, LICOS(human, mouse)

ICOS IGx2/TM L
21q22.3 A2aR 1

B7H1, PD-1 ligand, PD-L1 (human, mouse)

PD-1 IGx2/TM 1

9p24 TNFa, IFNg, LPS, Hp, Sm, STAT1, TLR4,dsRNA, B-DNA

PDL2, B7-DC (human, mouse)

9p24.2 IL4, IFNg, LPS, Ag, Sm, STAT6,

B7H3(human, mouse), 4Ig-B7-H3 (human)

(IGx4+)IGx2/TM L
15q23-q24 PMA/Io, Inf.cyt.
IFNg

B7-H4, B7S1, B7x (human, mouse, rat) (-)
BTLA IGx2/GPI

1p11.1

CD28 CD28, Tp44(human, mouse, rat,chick) inhibit/ mediate activate B7 family IG/TM L
2q33-q34 TNFa, TCR, Mt, MVA, Subst.P
T, targets, IL2, CD30, AP-1 ,NF-ATp

CTLA4, CD152(human, mouse, rat) mediate/ inhibit supress
IG/TM L
2q33 Tprim., OX40, AIRE L T

ICOS/AILIM(human) prevent

IG/TM L
2q33 TNFa, LPS, IL4, IL12, IL23

PD-1, PDCD1 (human, mouse) involved?
PDL1, SHP2 IG/TM/ITIM L
2q37.3 Pax5, Egr1, Nur77

BTLA (human)

B7H4, SHP1, SHP2 IG/TM/ITIM

3q13.2

B

CD1 CD1a (human, pig, horse)

glycolipid, B2M IG/TM

1q22-q23 GM-CSF, Hp, MVA
Thy

CD1b (human, rabbit, sheep b1, b2, b3, guinea pig b1, b2, b3, b4, horse)

glycolipid, B2M IG/TM

1q22-q23 VEGF, IL13
L Thy

CD1c (human, guinea pig c1, c2, c3)

glycolipid, , B2M IG/TM

1q22-q23 IL13
Thy, APCs, B

CD1d (human, mouse d1, d2, rat d1, d2, sheep)

glycolipid, B2M, MHCII, gp180 IG/TM L
1q22-q23 Sp1, IL13, LPS, hsp65, androgen, D3

APCs

CD1e (human, monkey, rabbit, guinea pig)

glycolipid IG/TM

1q22-q23

Thy

semaphorin semaphorin B, SEMB, SEMAB, SEMA4A (human)

1q22
Ma

semaphorin D, collapsin 1, SEMA3A (human) induce

1
7p12.1 FKHR

SEMA3B, SemA, SEMA5, SEMAA, LUCA1 (human)
induce

3p21.3

SEMA3C (human)

7q21-q31 TNFa

SEMA3D (human)

7q21.11

SEMA3E (human)

7q21.11

semaphorin J, SEMA4D , CD100 (human, mouse)

CD45, CD72 Sema/PSI/IG/TM 1
9q22-q31 CD40, LPS
B, T, NK, APCs

SEMA5A,semF, SEMAF (human)

5p15.2 VEGF, ARNT2

SIMA7A, JMH, CD108 (human, zebrafish)

CD232 Sema/PSI/IG/GPI

15q22.3-q23

plexin PLXNA1, PLXN1, NOV (human, mouse, Xl, Dm, Ce)

neuropilin-1, SEMA3A Sema/PSIx3/IGx4/TM(HAMP)/RasGAPx2

3q21-qter CIITA

PLXNA2 (human, mouse)

Sema/PSIx3/IGx4/TM(HAMP)

1q32.2 b-catenin

PLXNA3, SEX (human, mouse)

Sema/PSIx3/IGx4/TM

Xq28

PLXNA4 (human, mouse)

Sema/PSIx3/IGx4/TM

7q32.3

PLXNB1, PLXN5, SEP (human, mouse)

Sema/PSIx3/IGx3/cc

3p21.31

PLXNB2 (human, mouse)

Sema/PSIx3/IGx3/cc

22q13.33 estrogen

PLXNB3 (human, mouse)

Xq28

PLXNC1, VESPR (human, mouse)

PSIx2/TIG/IG/TM

12q23.3 FSH

PLXND1 (human)

3q21.3

IGSF IGSF2, V7, CD101 (human)

IGx7/TM

1p13

NF-ATc

IGSF3 (human)

1p13

Group Protein Species apoptosis NF-kB act. Binding Partner Structure KO gene locus regulators 3D memo

LIR ILT2, LIR1, CD85J, MIR7, LILRB1 (human) inhibit?
HLA-A, B, HLA-G1, HLA-F (MHC-I), SHP1 IGx4/TM/ITIM

19q13.4
1 APCs, inhibit T act.

ILT4, LIR2, LILRB2, CD85D (human)

HLA-A,B,G1,F IGx4/TM/ITIM

19q13.4 Fas, IL13

LIR3, ILT5, LILRB3, CD85A, LILRB3 (human)

MHC-I IGx4/TM/ITIM

19q13.4

LIR4, ILT6, HM43, CD85E, LILRA3 (human)

FcRgamma IGx4

19q13.4 TIMP1
APCs

LIR5, ILT3, LILRB4, CD85K (human)

MHC-I IGx2/TM/ITIM

19q13.4 St PhoP, Fas
APCs

LIR8, LILRB5, CD85C (human)

FcRgamma IGx4/TM/ITIM

19q13.4

LIR7, ILT1, CD85H, LILRA2 (human)

FcRgamma IGx4/ITAM

19q13.4 IFNa
APCs

ILT7, CD85G (human)

FcRgamma IGx4/ITAM

19q13.4

mDC

ILT8, CD85B (human)

FcRgamma IGx4/ITAM

19q13.4

APCs

LIR6, LILRA1, CD85E (human)

FcRgamma IGx4/ITAM

19q13.4

ILT11, LIR9, CD85F (human)

FcRgamma IGx2/ITAM

19q13.4

preDC

ILT10, CD85M (human)

FcRgamma IGx3

19q13.4

LAIR1 (human) inhibit?
Ep-CAM, SHP1,SHP2,

19q13.4 G-CSF
APCs, B, T, NK

KIR (for NK) KIR2DL1/NKAT1(human)

HLA-C4,2,5,6 (MHC-I), B4 (/w S1), SHP1, SHP2 IGx2/TM/ITIMx2

19q13.4

NK

KIR2DL2/NKAT6(human)

HLA-C1,3,7,8 (MHC-I) IGx2/TM/ITIMx2

19q13.4
L NK

KIR2DL3, NKAT2, CD158b(human)

HLA-C1,3,7,8 (MHC-I) IGx2/TM/ITIMx2

19q13.4
1 NK

KIR2DL4, CD158d(human)

HLA-G, SHP2, SHP1(-) IGx2/TM/ITIM

19q13.4

NK, CD30

KIR2DL5 (human)

IGx2/TM/ITIM

19q13.4

NK

KIR3DL1, NKAT3, NKB1, CD158e (human)

IGx2/TM/ITIM

19q13.4

NK

KIR3DL2, NKAT4, CD158z (human)

HLA-A IGx2/TM/ITIM

19q13.4

NK

KIR3DL7 (human)

19q13.42

NK

KIR2DS1, CD158H (human)

HLA-C2,4,5,6, Syk, ZAP70 IGx2/ITAM

19q13.4

NK

KIR2DS2, NKAT5, CD158J (human)

HLA-B, C

19q13.4

NK

KIR2DS3, NKAT7 (human)

19q13.4

NK

KIR2DS4, NFAT8, CD158G (human)

HLA-C4

19q13.4

NK

KIR2DS5, NFAT9, CD158G (human)

19q13.4

NK

KIR2DS6, KIRX, CD158C (human)

KIR3DS1, NKAT4, CD158k (human)

IGx2/ITAM

19q13.4

NK

KIR3DL2 (human)

19q13.4

NK

IRTA1 (human)

IGx4/IM/ITIM

1q21

IRTA2, BXMAS1 (human)

IGx9/TM/ITIM

1q21

B

FCRH3 (human)

IGx4/IM/ITIM

1q21.2-q22

NCR LY95, NKp44, NCR2 (human)

HA, CD3zeta, DAP12, IG/TM

6p21.1 IL2

LY94, NKp46 (human)

HA, HN IGx2/TM

19q13.42 Mt, camptothecin,
NK

LY117, NKp30, 1C7 (human)

viral proteins IG

6p21.3

NK, (T, B)

Butyrophilin
Butyrophilin A1, BTN1A1 (human, mouse)

IG/TM/SPRY(ZF) 1

6p22-p21.3

fat droplets in the milk

BTN2A1, BTF1 (human)

IGx3

6p22.1

T, NK, B

BTF1, BT2.1, BTN2A2 (human)

6p22.1

BTN2A3 (human)

6p22.1

BTF5, BT3.1, BTN3A1 (human)

6p22.1

T, NK

BTF4, BT3.2, BTN3A2 (human)

6p22.1

T, NK, (B)

Butyrophilin 3, BTN3A3 (human)

6p21.3 dsRNA
NK, T, (B)

Butyrophilin 2, BTNL2, BTL-II, HSBLMHC1 (human)

6p21.3 A2aR
sarcoidosis

BTNL3 , BTNLR (human)

IG/TM/PRY/SPRY

5q35.3

BTNL8 (human)

5q35.3

PBL

BTNL9 (human)

5q35.3

PBL

a1B a1B-glycoprotein, A1B, ABG, GAB, A1BG (human, rat)

CRISP3 IGx5

19cen-q13.2

Liver

beta-2-microglobulin B2M (human, mouse, rat)

CD1s
IG L
15q21-q22 NF-kB, GR, IRF1, TNFa, IL1, LPS, IFNg, IL1b/IFNg, MDV, HCV, IKKs

MHC-I HLA-A(human),B-L mediate mediate TCR, antigen, MIR MHCI/IG/TM L
6p21.3 AP1, NF-kB, Ets1, TNFa, TRAIL, RANKL, Fas, IL1, IFNs, CREB, PLZF, CBP, p300, PCAF, BRG1, CIITA, RA, IL1b/IFNg, LPS, hsp65, Hp, Hf, Sd, dsDNA, dsRNA, MDV, EV71, hypoxia, CSV-B3, HNF4a, IKKs, ALK1, TGFR1, calcineurin, T3, androgen, HHT L targets

FcRn, FCGRT (human)

B2M, IgG MHCI/IG/TM

19q13.3 IFNa, calcineurin 1 APCs, liver, passive immunity by milk

MHC-II HLA-DMa(human), b, DNa,DOa, DPa1, DPa2, DPb1, DPb2, DQa1, DQa2, DQb1-3, DRa, DRb1-9 mediate/inhibit mediate TCR, antigen, CD1d MHCII/IG/TM L
6p21.3 RFX5, RFX1, RFXAP, RFXANK, CIITA,NF-Y, CREB, Oct1, C/EBPa, AP1, AIRE, c-Myc, NF-IL6, STAT3, Stat4, ARNT2, TAF1, HDAC1, IFNg, IL1b/IFNg, GM-CSF, TNFa, Fas, CD40L, CD3/CD28, IL12, IL15, jagged-1, IL10, GM-CSF, insulin, IGF-II, LPS, hsp65, MDP, Hp, Hf, Sd, CpG, dsDNA, dsRNA, HCV, EBV, EV71, VLP, PTEN, Lyn, A2aR, TIMP1, triptolide, estrogen, androgen, RA, camptothecin L APCs, B,
targets

MIC MICA (human), mouse (RAEI, H60)

NKG2D MHCI/IG/TM

6p21.3 stress, IFNg, IL15
epithelial

MICB (human)

NKG2D MHCI/IG/TM

6p21.3 stress, IFNg, IL15
epithelial

CD74, HLA gamma, invariant chain (human),mouse, rat, horse, bovine,

CD74 1
5q32 androgen, HCV, Lyn, TIMP1

B, DC

CD92, CDw92, CTL1 (human)

CD74/DUF580

9q31.2

Tandem gene information:
mouse MHC; I(K), II{A(Ab, Aa),E(Eb, Ea)}, III{S(C4, Bf, C2, TNF)}, I{D(D,L), Qa(Q1, Q2...), T1a(T1, T2...)}, M(M1,..., NM7)
human HLA 6p21.3; II/D(DPB, DPA, DQB, DQB, DRB, DRA), III(C4B, C4A, Bf, C2, TNF), I (B, C, E, A, H, G, F)
19q13.42 loci of LIR/KIRs/NALPs; , LIRLRB3, LIRLRB5, LIRLRB2, LILRA3, (tweeny), LILRA2, LILRA1, LILRB1, ILT10, KIR2DS4, KIR2DL1, KIR2DL2, Fc alpha R, KIR2DL4, NK-p46, Pypaf3, Nalp2

Adhesion, Anchoring, Transcytosis, Anti-Adhesion Molecules, NKRs and Related Proteins

Group Protein apoptosis Species locus KO 3D binding partner structure TFs upstream regulators memo

CAM ALCAM, MEMD, CD166
human, mouse, rat, dog, chicken 3q13.1-q13.2

CD6 IGx5/TM
RANTES, LPS, IL3, M-CSF, GM-CSF, Blimp1

CD22, LEU14, BL-CAM, SIGLEC2
promote human, mouse 19q13.1 L
sialylated staffs, CD45, AP50, SHIP1/Grb2/Shc IGx7/TM
IL1b, Fas, BCR, Lyn, LPS, GR, IKKg B vs B

MAG, SIGLEC4A
human, mouse
19q13.1

sialosides IGx4/TM
DEX, cAMP
brain

LU, BCAM
human 19q13.2

IGx5/TM

nephrin, Nphs1
human 19q13.1 1

IGx8/FN3/TM

CD33, SIGLEC3 induce
human 19q13.3-q13.4 1
sialosides

SDF1, Lm
APCs

SIGLEC5, CD33L2, OBBP2
human 19q13.3

sialosides IGx3/TM

bm

Nr-CAM, Bravo, NRCAM

human, mouse, rat, chicken 7q31.1-q31.2

contactin/F11, neurofascin, RPTPb, axonin-1 IGx6/FN3x3/TM LEF-1 IL1a, b-catenin, Wnt brain

DDM36, NOPE

human 15q22.2

neogenin, NEO1
human 15q22.3-q23

IGx6/FN3x6/TM Pax6

PUNC
human 15q22.3-q23 1

IGx4/FN3x2/TM

MYBPC3
human 11p11.2

IGx6/FN3x2/IG/FN3/IG

heart

MYBPC2, fast
human 19q13.33

IGx5/FN3x2/IG/FN3/IG

heart, tongue

MYBPC1, slow
human 12q23.3

IGx5/FN3x2/IG/FN3/IG

skeletal muscle, tongue

contactin 1, CNTN1
human, mouse, rat, bovine, chicken,zebrafish 12q11-q12 1
tenascin, Fyn, RPTPbeta, Caspr, NF155, Na+ channel IGx6/FN3x4
St PhoP brain

contactin 2, CNTN2, TAX1, TAG1, axonin 1
human, rat, chicken, zebrafish 1q32.1 1

IGx6/FN3x4

brain

neurofascin, NFASC
human, rat, 1q32.1

contactin, Na+ channel, Nr-CAM, syntenin-1, ankyrin
IGx6/FN3x3/TM

IGSF9, Nrt1
human 1q22-q23

IGx4/FN3x2/TM

L1CAM, MIC5, MASA, SPG1, HSAS1, N-CAML1 CAML1, CD171

human, mouse, rat,
Xq28 1

IGx6/FN3x4/TM Pax6
brain

contactin 5, NB2, CNTN5
human, rat 11q21-q22.2

contactin 3, CNTN3, NIG1, PANG
human, mouse, rat 3p26

contactin 4, BIG2, CNTN4, Axcam
human, mouse, rat, 3p26-p25

IGx6/FN3x4

contactin 6, NB3, CNTN6
human, mouse, rat 3p26-p25

IGx6/FN3

CALL, L1CAM2, CHL1 mediate? human 3p26.1

IGx6/FN3x4/TM

brain

ROBO1, roundabout 1
human 3p12

IGx5/FN3x2 TNFa

ROBO4
human 11q24.2

IGx2/FN3x2

BOC
human 3q13.2

IGx4/FN3x3/TM

JAM3
human, mouse 11q25

JAM2, VEJAM
human, mouse 21q21.2

DSCAM, CHD2-42, CHD2-52

human 21q22.2

IGx9/FN3x2/IG/FN2/TM

NCAM2
human 21q21.1

IGx5/FN3x2/TM
EV71

NCAM1, CD56
human, mouse, rat, bovine, chicken, Xl, zebrafish 11q23.1 L 1 prion IGx5/FN3x2/TM NF-kB, Phox2, HOXC6, Hoxc8, Alx4, LEF-1, PLZF, OTX2, Cux-2?, Barx1, p73 TGFb, BMP2, AMPA-R, D2R NK

CDON, CDO, ORCAM
human 11q23-q24

IGx5/FN3x3/TM

DSCAML1, KIAA1132
human 11q23

IGx9/FN3x4/IG/FNx2/TM

SDK2, sidekick 2
human 17q25.2

IGx3/FN3x5/TM

DCC, CRC18, CRCR1 induce human 18q21.3 1

IGx4/FNx6/TM

VCAM1, CD106 inhibit human, mouse, rat, pig 1p32-p31 1 L integrins, CD29 IGx6/TM NF-kB, Egr1, AP-1, IRF1, IRF2, GATAs, Sp1,PPARa, IL1, TNFa, LTa,dsRNA, IFNs,AngII, IL4, IL5, IL18, PKR, LDL, thrombin, C5a, Resistin, NO, RA, estrogens, glucocorticoids, UTP, LPS, BLP, Ct, Hp, Mt, Pc, ApoE, tax, osmolarity, P2Y2, p38, BMP2, IL10, ALA

ICAM1, CD54 inhibit/(-)/mediate human, mouse, rat, pig, sheep, bovine 19p13.3-p13.2 L L LFA-1, rhinoviruses, CD11, CD43, MIR IGx5/TM NF-kB, p53, c-Myc, EGR1, DLX-7, HOXD10, PDX1
IL1, IL5, IL6, IL18, TNFa, LTa, TRAIL, Fas, IFNa, PMA, CD3/28, BCR, C4BP, histamine, C5a, ML-1, LPS, BLP, LTA, MDP, OX-CA, LeIF, hsp65, Bm, Cp, Ct, Ld, Lm, Ma, Mt, Pc, St, Tg, CMV(IE2, pp70), MV, HHV8, oxidative stress, irrrad, hypoxia, IFNg, RA, glucocorticoid, p38, PKCd, Src, Nef, IL1b/TNFa, heat shock, PGE2., IL10

ICAM3, CD50 mediate human, bovine 19p13.3-p13.2

LFA-1, CD11, CD209 IGx4/TM
IFNa B, T, APCs

ICAM4
human 19p13.2-cen

LFA-1 IGx2/TM

ICAM5, TLCN, TLN
human, mouse 19p13.2

IGx7/TM

PECAM1, CD31 inhibit human, mouse, bovine, pig, 17q23 L
CD38, Fyn, Lyn, Src, Yes, Hck, SHP1, SHP2, alphavbeta3 integrin, IGx5/TM/ITIM NF-kB, Egr1 TNFa, Fas, IFNa, IFNg, PMA, camptothecin APCs

ICAM2, CD102 inhibit human, mouse 17q23-q25 1 1 LFA1, CD11b/CD18, CD209 IGx2/TM GATA2, TNFa, IL1, VEGF, Cp, Yp, ALK1

TCAM1
mouse, rat

testis

CMRF35
human 17q22-q24

IG/TM
Fas, camptothecin monocyte

CMRF35H9, IRC1
human 17q22-q24

IG/TM

NK, APCs

TREM4, LOC146894
human 17q21.31

IG/TM

NKIR
human 17q25.2

IG/TM

TACTILE
human 3q13.2

IGx3/TM

T, NK

LAMP, LSAMP
human 3q13.2-q21

IGx3/TM

IGSF10, CMF608, FLJ25972
human 3q25.1

IGx7

MAdCAM1
human, mouse, rat 19p13.3
L CD29 IG NKX2.3 Hp, b-catenin

CEA, CEACAM5, CD66e inhibit human 19q13.2

IG x7 c-Myc, PPARg LPS,cisplatin

CD66a, BGP, CEACAM1 (-)/induce human 19q13.2
1 Src, SHP1, SHP2, galectin-3 IGx3/TM/ITIM Hoxd10 RA, VEGF

CGM1, CD66d, CEACAM3 induce human 19q13.2

IG/TM

CEAL, NCA, CD66c, CEACAM6 inhibit human 19q13.2

IG x7
estrogen, As2O3 lung, bm

CEACAM7, CGM2
human 19q13.2

IGx2
RA

CD66b, CD67, CGM6, NLA95, CEACAM8
human 19q13.2

galectin-3 IGx3
hemin, PACAP

PSG3
human 19q13.2

IGx4

placenta

PSG8
human 19q13.2

placenta

PSG10
human 19q13.2

placenta

PSG1
human 19q13.2

placenta

PSG6
human 19q13.2

placenta

PSG7
human 19q13.2

placenta

PSG11
human 19q13.2

placenta

PSG2
human 19q13.2

placenta

PSG5
human 19q13.2

Sp1

placenta

PSG4
human 19q13.2

placenta

PSG9
human 19q13.2

placenta

TSLL2
human 19q13.32

IGx3/TM/4.1m

SIGLEC7
human 19q13.3
1
sialic acid, disialogangliosides, sialosides IGx3/TM
Fas, camptothecin NK, APCs

SIGLEC8, SAF2
human 19q13.33-q13.41

sialosides IGx3/TM

SIGLEC9
human 19q13.41

sialosides

SIGLEC10
human 19q13.3

IGx4/TM

B, NK

SIGLEC11
human 19q13.33

IGx4/TM

adrenal gland

SIGLECL1
human 19q13.4

IGx4/TM

OSCAR
human 19q13.42

IGx2/TM PU.1

PVR, PVS, CD155 mediate human 19q13.2-q13.3 mt
PV, vitronectin, Tctex-1
NRF1, GLI1, GLI3 Shh, CMV

basigin, BSG, TCSF, EMMPRIN, CD147

human, mouse, rat, chicken, zebrafish
19p13.3 L
basigin, MCT1, MCT4
IGx2/TM Stat4b TSH
bm

SDFR1, gp65, gp55
human 15q22

IGx2/TM

brain

embigin, gp70IC
human, mouse, rat 5q11.2

IGx2/TM

bm

MGC71745

human
5q11.2

IGx2/TM

NK, B, T, APCs

sialoadhesin, SN, CD169, SIGLEC1

human 20p13
L
sialic acid, sialosides IGx17/TM
IL-4, IFNb, IFNg, LPS
bm

NEPH1, KIRREL

human
1q21-q25

IGx4/TM

NEPH2, Kirre, SST4
human 11q24

IGx5/TM

MCAM, MUC18, CD146
human 11q23.3

IGx5/TM AP2 TNFa, IL1, hCG, PMA, cAMP

SYNCAM, TSLC1, BL2, ST17, IGSF4
human 11q23.2

IGx3/TM/4.1m

HVEC, PVRR1, PRR, nectin 1, PVRL1
human 11q23-q24 1
afadin, HSV IGx3/TM
Ma, Fas, camptothecin

nectin 2, Pvrl2, CD112, HVEB, PVR, PVS
human, mouse 19q13.2-q13.4 1

IGx3/TM

PVRL3, PPR3, PRR3, PVRR3, nectin-3,

human
3q13

afadin

placenta

CD47, IAP mediate human, mouse, rat, bovine, viruses 3q13.1-q13.2 L
SIRPs, alpha v beta 3 vitronectin, Rh, SHPS1 IG/TMx5
Yp, MVA, EV71, TNF, IL1, GM-CSF, NIP3, SDF1

CD200R, OX2R, MOX2R
human 3q13.2

CD200 IGx2/TM

CD200, OX2, MOX2
human 3q12-q13 1
CD200R IGx2/TM

CAM(IG) SNS, CG33141
Dm, Ag

IGx9/FN3/TM

CG8964
Dm

Tandem gene information:
19q13.2- 19q13.31; CEACAM1, CEACAM8, PSG3, PSG1, PSG6, PSG7, PSG11, PSG2, PSG5, PSG4, PSG9, PSG5, PSG4

Group Protein apoptosis Species locus KO 3D binding partner structure TFs upstream regulators memo

CD2 CD48 inhibit human, mouse, rat 1q21.3-q22

heparan sulfate, CD2, 2B4, Lck, CD2BP1, Lyn, Fyn IG/TM PLZF Yp, EBV, G-CSF, IL13, TRAF2/TRAF5
B, T, NK, APCs

BY55, CD160
human 1q21.1

MHC-I IG/GDI
TCR
NK

IGSF4B, NECL1, TSLL1
human 1q21.2-q22

IGx2/TM/4.1m

brain

LFA3, CD58 inhibit human 1p13
1 CD2 IG/TM p53 IL2, LPS, RA, DEX

AD026
human 1p12

IG

CD2 induce human, hourse, 1p13.1 1
L CD48, CD2BP1, CIN85, CMS IGx2/TM
Ma, PTH, Notch T, NK

CD84
human 1q24

CD2 family members,
SHP2, SAP IGx2/TM
D3 T

SLAM, CD150
human, mouse 1q22-q23

SAP IGx2/TM GR, STAT3 IL1, IL10, PMA,BCR, LPS, Hp Thy

Ly9, CD229
human, mouse 1q21.3-q22

SAP, CD48, AP-2 IGx2/TM AIRE
T, DC

2B4, CD244, Nmrk
human, mouse,rat 1q23.1 1

CD48 IGx2/TM
Rac2, TCR
NK

BLAME
human 1q22

IGx2/TM

SLAMF6, NTBA, KALI
human 1q22

SHP1, SHP2, SAP IGx2/TM/(TxYxxV/I)x2/ITIM

LNIR, PRR4, PVRL4
human 1q22-q23.2

IGx3/TM

SLAMF7, 19A24, CRACC, CD1
human 1q23-q24

IG/TM

DC, NK

SLAMF9, CD84-H1
human 1q22

IG/TM

F11R, JAM1, PAM-1
human, mouse, rat, bovine 1q21.2-q21.3
1 LFA1 IGx2/TM
IL5 epithelial

FGFRL1
human, mouse
4p16

IGx3/TM

IGSF4D, NECL3
human, mouse
3p12.2

IGx3/TM/4.1m

brain

CD83 CD83
human, mouse, rat 6p23 1
sialic acid
IG/TM NF-kB TNFa, CD40L, IFNg, CD38, IL4, PA, LPS, KF1B, Hp, Ld, Lm, Mt, Sm, Tg, Ye, LMP1, PMA, D3, Blimp1, TIMP1 B, APCs

TIM HAVCR, TIM1
human, mouse 5q33.2

HAV IG/Muc/TM

TIM2, Timd2
mouse

SEMA4A IG/Muc/TM
blastcysts

HAVCR2, TIM3
human, mouse 5q33.3 1

IG/Muc/TM

NK, Th1

TIM4, LOC91937
human, mouse 5q33.3

IG/Muc/TM

other pIgR
human, mouse, rat, rabbit, bovine 1q31-q41 1
IgA, CbpA, CaM, IGx5/TM IRF1, NF-kB, STAT6 IFNg, IL4, TNFa, androgen trtachea, IgA transport

FKSG87, Fcalpha/muR
human 1q31.3

IgA, IgM IG/?
IL1

Toso inhibit human, mouse, rat 1q31.3

FADD
IG/TM
IL2, TCR, Hp B, T, NK

kilon, MGC46680
human 1p31.1

IGx3

myopalladin, MYPN

human 10q22.1

IGx5

CNAIP, NFAM1
human, mouse 22q13.2

IG/TM/ITAM

kidney

MDGA1
human 6p21

IGx6/FN3/MAM/GPI

Thy-1, CD90 induce human 11q23.3

Mac1
IG
Yp brain

neurotrimin, HNT
human 11q25

IGx3/GPI

OBCAM, OPCML
human 11q25

IGx3

(brain)

DKFZp566D234
human 4q32.3

KAZAL/EF/IGx2

palladin, CGI151
human 4q32.3

ezrin (FPPPP)/IGx5

myotilin, TTID
human 5q31

?/IGx2

skeltal muscle, tongue

FLJ20674
human 12q24.23

IGx3/TM

SIRPa1, SHPS1, MYD1, MFR, PTPNS1 (promote) human 20p13

SHP1 UGx2/TM/ITIM

IGSF1, IGDC1
human Xq25

IGx5/TMx2/IGx6

pituitary

WFIKKNRP
human 17q21.33

WAP/KAZAL/IG/KUx2/C345C

perlecan, HSPG2, PLC, SJA, SJS, SJS1

human, mouse 1p36.1-p35

SEA/LDLax4/IG/LamB/EGFx3/LamB/EGFx4/LamB/EGFx3/IGx21/LamG/EGFx2/LamG/EGFx2/LamG
TGFb, NO adipocyte, s.muscle, cardiac

hemicentin, fibulin 6, FIBL-6
human 1q25.3

WVA/IGx3/TSP1x6/G2F/EGFx8

hemicentin-2
human 9q34.2

titin
human 2q24.3

huge!

skeletal muscle

LRR/IG LRIG2, KIAA0806
human 1p13.1

LRRs/IGx3/TM

GAC1, LRRN2
human, mouse, rat, 1q32.1

LRRs/IG/TM

brain

LRRN3, NLRR3
human 7q31.1

LRRs/IG/TM
IL12, TGFb T, brain

FLJ31810
human, mouse, rat 9p21.1-p13.3

LRRs/IG/TM

brain

LERN1, UNQ201,, FLJ14594
human, mouse, rat, 15q24.1

LRRs/IG

(brain)

LRRN1
human, mouse, frog 3p26.2

LRR/IG/FN3/TM

T

LRRN3
human, mouse, rat 7q21.12

LRR/IG/FN3/TM

T, brain

LIG1, LRIG1
human 3p14

LRRs/IGx3/TM

FLJ90440
human 12q13.2

LRRs/IGx4/TM

PAL
human 10q23

LRRs/IG/FN3/TM

adlican
human Xp22.33

LRRs/IGx2/?/IGx10

adrenal

Group Protein apoptosis Species locus KO 3D binding partner structure TFs upstream regulators memo

SRCR CD6 inhibit human, mouse, rat 11q13

CD166 SR x3/TM
PMA, Yp, D3 T

CD5, Leu1, Ly1 mediate human, mouse, rat, sheep, chicken, 11q13 1
CD72 SR x3/TM/ITIM NFATs, E47, Ets1 TNFa, TCR, PMA, IgM, IFNa, Yp, PKCs, androgen T

DMBT1, gp340
human 10q25.3-q26.1

SFTPD SRx13/CUB/SR/CUB/ZP

trachea

see also CD160, M160

SRs

cadherin BR-cadherin, N-cadherin 2, CDH12
human, mouse 5p14-p13

B

K-cadherin, CDH6
human, mouse, rat, chicken, Xl 5p15.1-p14

cadherin 18, CDH18 (formerly CDH14)
human, rat 5p15.2-p15.1

brain

LI-cadherin, CDH17
human, mouse, rat 8q22.1

Cad.R x6/TM Cdx2
Sd, Sp pancreas

E-cadherin, cadherin-1, CDH1 inhibit/promote human, mouse, chicken, zebrafish 16q22.1 L L cytoskeletal proteins Cad.R. x5/Cad/TM/Cad-C Snail, WT1, E12/E47, SIP1, Rb, c-Myc, AP-2, TGFb, DNA methylase, PS1, ET-1, LMP1, PMA

OB-cadherin, CDH11
human, mouse, chicken 16q22.1

PDGF s.muscle, cardiac, adipocyte

P-cadherin, cadherin-3, CDH3
human, bovine, pig 16q22.1 L
cytoskeletal proteins Cad.R. x5/ Cad/ TM/ Cad-C
ErbB2, ARNT2

VE-cadherin, CDH5, CD144 inhibit human, mouse, pig 16q22.1 1
b-catenin, p120CAS Cad.R. x5/ Cad/ TM/ Cad-C Sp1, Sp3, Erg, Ets1, Egr1, RANKL lung, placenta

cadherin 8, CDH8
human, mouse, rat 16q21-q22.1

KSP-cadherin, CDH16
human 16q22.1

kidney

M-cadherin, cadherin-15, CDH15
human, mouse 16q24.3

MVA, Pg

T-cadherin, cadherin 13, CDH13
human, mouse, rat, chicken 16q24.2-q24.3

Cad.R x5 NF-kB TNFa, IKKs, irrad

T1-cadherin, CDH9
human 5p14

T2-cadherin, CDH10
human, chicken 5p14-p13

brain

BH-cadherin, PCDH7, BHPCDH
human, chicken 4p15

PP1a Cad.R x7/TM NF-kB TNFa, IL1, IKKs

R-cadherin, cadherin-4, CDH4
human, mouse, rat 20q13.3

brain

PB-cadherin, CDH22
human, mouse, rat 20q13.1

PTH brain

VR20, CDH26
human 20q13.2-q13.33

epithelium

N-cadherin, cadherin-2, CDH2 inhibit human, mouse, bovine, chicken, zebrafish 18q11.2 L L cytoskeletal proteins Cad.R. x5/ Cad/ TM /Cad-C MyoD Rac2 s. muscle, cardiac

cadherin 7, CDH7
human, chicken 18q22-q23

cadherin 19, CDH19 (formerly CDH7)
human 18q22-q23

DRG

cadherin 20, CDH20
human, mouse 18q22-q23

desmocollin 1, DSC1
human, mouse 18q12.1 1

Cadx5/TM NF-IL6
skin, desmosome

desmocollin 2, DSC2
human, mouse 18q12.1

tongue, epithelium

desmocollin 3, DSC3
human, mouse, bovine 18q12.1

TNFa epithelium, tongue, skin

desmoglein 1, DSG1
human, bovine 18q12.1

Cadx5/CAD-C

skin, tongue

desmoglein 2, DSG2
human, mouse 18q12.1

epithelium

desmoglein 3, PVA, DSG3
human, mouse 18q12.1-q12.2 1

epithelium, tongue, tonsil

desmoglein 4, DSG4
human 18q12.1

PCDH10
human 4q28.3

brain

PCDH15
human 10q21.1 av

PCDH18
human 4

Disabled-1

adipocyte

FAT
human 4q34-q35

Cadx34/EGF/LamininG/EGFx4/TM

epithelium

FAT2, MEGF1
human, rat 5q32-q33

cerebellum

otocadherin, CDH23
human, mouse,rat 10q21-q22 mt

group name apoptosis species locus KO 3D binding partner structure TFs upstream regulators memo

protocadherin alpha 1, PCDHA1
human 5q31

brain

PCDHA2
human 5q31

brain

PCDHA3
human 5q31

brain

PCDHA4
human 5q31

brain

PCDHA5
human 5q31

brain

PCDHA6
human 5q31

brain

PCDHA7
human 5q31

brain

PCDHA8
human 5q31

brain

PCDHA9
human 5q31

IL1
brain

PCDHA10
human 5q31

brain

PCDHA11
human 5q31

brain

PCDHA12
human 5q31

brain

PCDHA13
human 5q31

TNFa
brain

PCDHB1
human 5q31

PCDHB2
human 5q31

PCDHB3
human, mouse 5q31

PCDHB4
human, mouse 5q31

PCDHB5
human, mouse 5q31

PCDHB6
human, mouse 5q31

PCDHB7
human, mouse 5q31

PCDHB8
human 5q31

PCDHB9
human 5q31

PCDHB10
human 5q31

PCDHB11
human 5q31

PCDHB12
human 5q31

PCDHB13
human, mouse 5q31

PCDHB14
human, mouse 5q31

PCDHB15
human, mouse 5q31

PCDHB16
human, mouse 5q31

Pcdhb22
mouse

protocadherin gamma A1, PCDHGA1
human, mouse 5q31

brain

PCDHGA3
human, mouse 5q31

brain

PCDHGA4
human 5q31

brain

PCDHGA5
human 5q31

brain

PCDHGA6
human 5q31

brain

PCDHGA7
human 5q31

brain

PCDHGA8
human, mouse 5q31

brain

PCDHGA9
human, mouse 5q31

brain

PCDHGA10
human 5q31

brain

PCDHGA11
human 5q31

brain

PCDHGA12
human 5q31

brain

protocadherin gamma B1, PCDHGB1
human, mouse 5q31

brain

PCDHGB2
human, mouse 5q31

brain

PCDHGB3
human 5q31

brain

PCDHGB4
human 5q31

Cadx5/TM

brain

PCDHGB5
human 5q31

brain

PCDHGB6
human 5q31

brain

PCDHGB7
human, mouse 5q31

brain

Pcdhgb8
mouse 5q31

protocadherin gamma C3, PCDHGC3
human 5q31

brain

PCDHGC4
human, mouse 5q31

brain

PCDHGC5
human 5q31

brain

PCDH12
human 5q31

brain

PCDH1
human 5q32-q33

PCDH19
human Xq13.3

brain

PCDH11X
human Xq21.3

PCDH11Y, protocadherin-PC affect? human Yp11.2

protocadherin 15, PCHD15
human, mouse 10q21-q22 US

Cadx11/TM

protocadherin 16, PCDH16
human 11p15.4

PCDH8, PAPC
human 13q14.3-q21.1

Mesp2 brain, epithelium boundary

PCDH9
human 13q14.3-q21.1

brain

PCDH17
human 13q14.3

IL1
brain

PCDH20
human 13q21

brain

CDH24, FLJ25193
human 14q11.2

Cadx4

also see flamingo subfamily of 7TM

tandem gene information:
5p31; PCDHA1-13 (common C-terminas), PCDHB1, 2,3,4,5,....15, PCDHGA1-A12/B1-B7 (common C termimus)

group name apoptosis species locus KO 3D binding partner structure TFs upstream regulators memo

integrin alpha 1, CD49a, ITGA1
human, mouse, rat, 5q11.1 1

FG-GAP/VWA/FG-GAPx4
Sd, Ct

alpha 2, CD49b, ITGA2 inhibit human, mouse, bovine 5q23-31

FG-GAP/VWA/FG-GAPx4/TM/Int_A Sp1, Osf PMA, PDGF, SCF, IFNa, Lm, PKCzeta, Erb-B2, v-Ras, hypoxia, HHV8

alpha 2b integrin, CD41,

human, mouse 17q21.32

FG-GAPx5/TM/Int_A C/EBP
bm

alpha 3, CD49c, ITGA3 inhibit human, mouse 17q23.3

TM4SFs FG-GAPx5/TM
Ma, irrrad, RANKL epithelium

alpha 4 , CD49d, ITGA4 inhibit human, mouse 2q31-q32 1
TM4SFs

IL-2RIF, IL6, LPS, Pg, TIMP1
B, T, NK, APCs

alpha 5 , CD49e, ITGA5 inhibit human, mouse, Xl 12q11-q13 1
TM4SFs, ADAM17
Sp1, Sp3, Smad4, C/EBP, Ets LPS, OX-CA, Ct, TNFa, RANKL, IL10, TGFb1, IGFBP2, IGF1

alpha 6 , CD49f, ITGA6
human, mouse, chicken 2q31.1

TM4SFs
c-Myc CD3, insulin, IGF1, insulin, FSH, TGFb1, Tprim, RA, hypoxia, MA3Ks, IGFBP2, LPS, Sm
epithelium

alpha 7, ITGA7
human, mouse 12q13

Stat4 b-glucan, Ma, BMP2, BMPs, HIV Vpr heart, adipocyte

alpha 8, Itga8
human 10p12.32 1

cisplatin, phenytoin

alpha 9, ITGA9
human, mouse 3p21.3

estrogen

alpha 11, ITGA10
human 1q21

alpha 11, ITGA11
human 15q22.3-q23

alpha E integrin, CD103
human, mouse, rat E1, 17p13

E-cadherin, beta 7 integrin

TGFb, Ct, Pg, ALK1, ALK5, PMA, cisplatin, estrogen

alpha L, CD11a, LFA-1a, ITGAL
human, mouse 16p11.2 1

MDP, Cp, Ma, EV71, RANKL, IFNa
T, NK

alpha M, CD11b, MAC1A, MO1A, ITGAM, CR3A mediate human, mouse, rat 16p11.2 1

Sp3 SCF, TNFa, LTa, IL2, IL4, hemin, PACAP, Am80, MDP, Ma bm, NK,
induce NF-kB

alpha V integrin, CD51, ITGAV mediate/ inhibit human, mouse, chicken 2q31-q32

ADAM15, alphaV, ntin
GATA1 TNFa, PMA

alpha X integrin, CD11c, ITGAX
human, mouse, rat 16p11.2

Sp1, Sp3, AP1, Ets,Oct2, c-Myc, GABP, Pur alpha, PU.1 GM-CSF,TNFa,LTa, IL2, IL4, PMA, Hp, Ma, CSBG, SB, PKCzeta,,fibronectin, SDF1 NK, DC

alpha D, CD11d, ITGAD
human 16p13.1-p11

Sp1, Sp3

beta 1, CD29, ITGB1
inhibit human, mouse, rat, bovine, Xl 10p11.2 L
VCAM1, MAdCAM1, TM4SFs, ADAM17 PSI/VWA/TM c-Myc, N-Myc, NF-kB, HOXD10, Pax6, SCF, TNFa, GM-CSF, PMA, LPS, MDP, Ma, HCV, hypoxia, cisplatin, TIMP1

beta2 , CD18 inhibit/ mediate human, mouse, 21q22.3 L

PSI/VWA/TM PU.1, NRF2, GABPs TNFa, LTa, IL2, IL4, SCF, MDP, Hp, Ma, Mt, Tc, HCV, MVA
induce NF-kB

beta3 , CD61, GP3A, ITGB3 mediate/ inhibit human, mouse, rat 17q21.32 1
ADAM15, alphaV, osteopontin
HOXA10, Stat6, ARNT2
b-glucan, D3, IL4
calpain

beta 4 , CD104, ITGB4 inhibit human, rat 12q13.13

laminins, alpha 6 integrin
GABPs TGFb1, SCF, HIV Vpr, SDF1

beta 5, ITGB5
human, mouse, bovine 3q21.3

betaig-h3
Sp1, Sp3, PU.1 GM-CSF, PMA, TGFR1, RA, insulin, IGF-II

beta 6, ITGB6
human, mouse, bovine 2q24.2 L

CD3, hypoxia

beta 7 , ITGB7
human, mouse 12q13.13

IL-2RIF, TGFb1, UVB, cisplatin B, T, NK, DC

beta 8, ITGB8
human 7p21.3

Fas, LPS, Ma, cisplatin

Tenascin-C, TNC, cytotactin, HXB
human, mouse, pig, chicken 9q33 1

EGFx14/FN3x15/FBG
TNFa, D3, HPV16 epithelium, adipocyte

LINK CD44 inhibit human, mouse, rat, bovine 11p13 L
hyaluronan, aggrecan, collagen, IpaB LINK/TM Egr1, AP1, HMG-I, TEL, EWS/FLI-1, Hoxd10 EGF, TNFa, RANKL, IL1b, IL2, IL5, IL10, M-CSF, GM-CSF, OPN, LPS, MDP, Ct, Ma, Ld, Lm, Mt, Tg, PMA, dsRNA,irrad, PKCs, Ca, BMP2, TIMP1, ROK, VDR, A2aR, estrogen, P2Y2

LYVE-1
human, mouse 11p15

hyaluronan LINK/CUB
Prox1, VEGF-C lung, placenta

TSG6, TNFAIP6
human, mouse 2q23.3 1 1 hyaluronan

IL1, TNFa, G-CSF, LPS, MDP, LTA, Bm, Ld, Lm, Mt, Tg, AmB neutrophil migration

stabilin 1, STAB1

human, mouse 3p21.31

hyaluronan EGFx6/FAS1x2/EGFx5/FAS1x2/EGFx6/FAS1x2/EGFx5/LINK/FAS1/TM

bm, monocyte

FELL, stabilin-2
human, mouse 12q23.1

hyaluronan EGFx6/FAS1x2/EGFx5/FAS1x2/EGFx6/FAS1x2/EGFx5/LINK/FAS1/TM

aggrecan 1, AGC1
inhibit human, mouse 15q26.1 m
CD44 IG/LINKx2/(SGXXSG)xn/CLECT scleraxis, SOX9; ADAMTS5

BEHAB, brevican, BCAN
human, mouse, Xl 1q31 1

hyaluronan IG/LINKx2/EGF/CLECT/CCP
brain

chondroitin sulfate proteoglycan 2, versican, CSPG2
human, mouse 5q14.3

IG/LINKx2/EGFx2/CLECT/CCP Rb, bm, monocyte, Wnt-3A, D3, irrad

neurocan, CSPG3
human, mouse 19p12 1
CD56, tenascin-C, Ng-CAM, , IG/LINKx2/EGFx2/CLECT/CCP
brain

BRAL1
human, mouse 1q21.2

IG/LINKx2
spinal cord, brain

CRTL1
human, mouse, chick 5q14.3

cardiac

group name apoptosis species locus KO 3D binding partner structure TFs upstream regulators memo

Tetraspanin (TM4) CD9 induce human, mouse, rat, cat, bovine, pig, chicken, zebrafish, trout, salmon 12p13 L
CD63, CD81, CD82, PCG17, HLA-DR, -DM, DO, PKC Tetraspanin
St PhoP, PMA, VEGF, UVB, D3, TCR, calcineurin targets

IgE Fc R b, CD20, MS4A1 mediate/inhibit human, mouse 11q13

Tetraspanin
irrrad B

ROM1, ROSP1

human
11q13

Tetraspanin

TM4-B

human
19p13.2

Tetraspanin

CD37
human, mouse 19p13-q13.4 L
CD53, CD81, CD82, MHC-II, PKC Tetraspanin
D3, androgen, OX40, IL3, IL13
B

CD53 inhibit human, mouse, rat 1p13

VLA4, HLA-DR, PKC, CD49d/CD29, Tetraspanin
GnRH, IL3, Tg, Hp, Sp, PMA, androgen, camptothecin, cisplatin, staurosporine, paclitaxel, LiCl B, T, NK, APCs

CD63 (?) human, mouse, rat, rabbit, bovine, Xl 12q12-q13

VLA3, 6, HLA-DR, CD9, CD49d, CD29, CD81, CD82, AP3 Tetraspanin c-Myc LPS, PACAP, IL5

LOC90139

human
11p11.2

CD82, kangai 1, KAI1, SAR2, ST6 induce human, mouse 11p11.2

CD4, CD63, HLA-DR, VLA 3,6, CD49d/CD29, PKC, HIV1 gp Tetraspanin p53, NF-kB irrrad, BMP2

CD81, TAPA1 regulate human, mouse, rat, Ca, So, zebrafish 11p15.5

Leu13/CD19/CD21, HLA-DR, CD49d/CD29,CD4 Tetraspanin
HIV Vpr liver, lung

CD151, PETA-3
human, monkey, mouse, rat 11p15.5 1

a3b1, a4b1, a5b1, a6b1, a6b4, aIIbb3, integrins, PI4K, PKC Tetraspanin
Ret

PHEMX, TSSC6

human
11p15.5

Tetraspanin

T, NK

TSPAN-1, tetraspan 1, NET-1
human, mouse 1p34.1

Tetraspanin p73
epithelium

TSPAN-2, tetraspan 2, TM4SF
human, mouse, rat, 1p13.1

Tetraspanin
TGFb
bladder

NET-2, TM4SF12

human, mouse 7q31.31

thyroid

tetraspan 3, TM4SF8, TSPAN-3
human, mouse 15q24.1

Tetraspanin
TNFa, RA, B-DNA

TSPAN-5, tetraspan 5, NET-4, TM4SF9

human, mouse 4q23

Tetraspanin

CD71+

DC-TM4F2

human
10q23.1

Tetraspanin

CO-029, TM4SF3
human, mouse, rat 12q14.1-q21.1

Tetraspanin
HOX11

NET-5
human, mouse, rat 12p13.33

Tetraspanin

SAS
human, mouse, Xl, zebrafish 12q13.3

Tetraspanin
Ma

NET-6, TM4SF13

human, mouse, rat 7p21.3

Tetraspanin
IL12 DC

MGC50844

human
7q32.3

Tetraspanin

B, kidney

NET-7
human 10q22.1

Tetraspanin

EMP2
human, mouse, Xl 16p13.2

Tetraspanin

lung

UPK1A, uroplakin 1A, UPIA, UPKA

human
19q13.13

Tetraspanin

UPK1B, uroplakin 1B

human
3q13.3-q21

Tetraspanin

trachea

LOC116441, BC014339
human 3q24

Tetraspanin

ILTMP, TM4SF4
human, mouse 3q25

b1 Tetraspanin

liver

LOC116211, BC013113
human 3q29

Tetraspanin

L6H, TM4SF5
human, mouse, rat 17p13.3

Tetraspanin

liver

OCSP, oculospanin

human
17q25.3

Tetraspanin

CD231, TM4SF2, MXS1, A15
human, mouse Xq11.4

Tetraspanin
FSH brain

TM4SF6
human, mouse Xq22

Tetraspanin

tetraspanin 4,NAg2, TM4SF7
human, mouse 11p15.5

Tetraspanin

TM4SF1, M3S1, TAAL6
human, mouse 3q21-q25

Tetraspanin NF-IL6, EWS/FLI-1 TNFa, Ld, Lm, Mt

SB134, FBX23, MGC14859
human, mouse 5q35.3

Tetraspanin

RDS, RP7, AVMD, PRPH, AOFMD, PRPH2

human
6p21.2-p12.3

Tetraspanin

PMP22 (TM4) PERP, PIGPC1, KCP1 induce human, mouse, rat 6q24 1

p53 epithelium

BCMP1, TM4SF10
human, mouse, frog Xp11.4

brain, spinal cord, adipocyte

LIM2, MP19
human 19q13.4

podocalyxin
CD34
human, mouse, goat, pig, bovine, dog, cat 1q32

L-Selectin, CrkL podocalyxin/TM c-Myb, Ets2,NF-Y, Sp1, MZF1, NC-3A, TGFb1, TGFR1, VEGF, UVB, ALK1, TNFa
bm

podocalyxin 1, PCLP, Gp200, GCTM2, PODXL

human
7q32-q33
1

L-selectin, ezrin, NHERF2
podocalyxin/TM WT1, p53

kidney

endoglycan, PODLX2

human
15

brain

mucin mucin 1, MUC1 inhibit human, mouse 1q21 L
CD169 simple repeats/SEA/TM c-Myc IFNg, TNFa, IL7, PMA, TACE, estrogen lung

mucin 2, MUC2
human, mouse 11p15.5 L

Smad3/4, Stat4, NF-kB, Sp1, Sp3, GATA5
TGFb, TNFa, IL1, IL9, EGF, PMA, RA, Hi, adenosine, VitA

MUC3A
human 7q22

GATA5 IL4, IL6, EGF, PMA

MUC3B
human 7q22

MUC4
human 3q29

VWD Smad2/7, PEA3, GATA5
ErbB2, TACE, smoke
trachea

mucin 5AC, MUC5AC
human 11p15

H. pylori,

CREB, Sp1
TNFa, IL1, IL4/(-), IL6, IL9/(-), IL13/(-), IL17, TGFb, EGF, PAF, LPS, Pa, RSV, Rhinovirus, chymase, smoke, DEX, PGE2, azithromycin; TACE
trachea

mucin 5B, MUC5B
human, mouse 11p15

c-Myc IL6, IL17 trachea

MUC6

human
11p15.5-p15.4

VWD/ZnF/VWD//TILx2/extensin/CT

TGFb

mucin 8, MUC8
human 12q24.3

TNFa, IL1

VWF
human, mouse 12p13.3 1

lung

sialophorin sialophorin, SPN, leukosialin, CD43 inhibit human, mouse, rat 16p11.2 L
ICAM1, moesin, ezrin ?/TM
Pur alpha, estrogen, Ma, Tc targets

sialomucin CD164
human 6q21

AraC DC, placenta

MIC2 MIC2, E2, CD99
human Xpter-p22.32, Ypter-p11.2

?/TM
ribavirin

lysosomal/ plasma membrane shuttling, scavenger
CD68
human, mouse 17p13

Lamp/TM Elf1, PU.1, IRFs, AIRE GnRH, Ct, Sp, HCV, EV71, Blimp1

LAMP1
human

LAMP2
human
Xq24 1

calcineurin

LAMP, DCLAMP, TSC403, DC-LAMP, LAMP3
human
3q26.3-q27

LAMP/TM

LPS, TNFa, Fas, CD40L

Syndecan Syndecan 1, CD138 inhibit human, mouse, rat, frog, Dm 2p24.1 1

Syndecan
WT1 RANKL, thrombin, FGF2, PDGF-BB, TGFb1, IL1b, RA, D3 epithelium, placenta, liver,
shadding by Pa

Syndecan 2, SDC2, SYND2, HSPG, HSPG1, fibroglycan
human 8q22-q23

TRRAP thyroid, liver, adipocyte

Syndecan 4, amphiglycan, ryudocan, SDC4
human 20q12 1

NF-kB TNFa, IL1, PTH, VEGF, A2aR, Ye

Syndecan 6 human

RANKL

PSGL1, CD162, SELPLG
human 12q24

P-selectin, E-selectin Syndecan/TM
G-CSF

CD24 CD24 induce human, mouse, rat 6q21 L
CD24
AIRE Sp, Sm, EV71, aa stavation, estrogen, androgen, PMX2, La(NO3)3
thyroid, B, epithelium

ECM1
ECM1 (human)

1q21

activate NF-kB

LAB LAB, WBSCR5
human, mouse, rat, 7q11.23

Grb2, PLCg1, PLCg2

B, NK, monocyte, bm

group name apoptosis species locus KO 3D binding partner structure TFs upstream regulators memo

selectin L-selectin, LAM, LEU8, CD62L, SELL (inhibit) human, mouse 1q23-q25 L
carbohydrate ligands; GlyCAM-1, CD15su, CD34, PCLP, PSGL1, ELAM, nucleolin, CD162R CLECT/EGF/Sushi x2/TM STAT1, STAT3 IL2, IL3, OX40, Cp, Ct, Ma, tax, CsA/FK506, staurosporine
B, T, NK, APCs

E-selectin, ELAM, CD62E, Sele
human, mouse 1q22-q25 L L carbohydrate ligands; ESL1,CD44, CD15s, PSGL1, CD65, LAM CLECT/EGF/Sushi x6/TM NF-kB, ATF2, ATF3, c-Jun,NFAT,A20, STAT6, Smads, IL1, LPS, BLP,dsRNA, TNFa, LTa, TRAIL, radiation, IL4, IL1Ra, C5a, glucocorticoid, IFNg, TGFb, JNK, MEKK1, TMS, UVB, NO, flavonoids, cAMP, PPAR, PMA, tat

P-selectin, GRMP, CD62P, Selp
human, mouse 1q23-q25 L L PSGL-1, CD15, CD15u, CD24, CD162 CLECT/EGF/Sushi x9/TM NF-kB, Bcl-3,STAT6, TNFa, Fas, LPS, trauma,IL4, MCP1

siglec, other CD23, low aff. IgE RII, FCER2
human 19p13.3 L
IgE, CD21, CD11b, CD11c cc/CLECT CBF1 BAFF, IL4, Notch2, EBNA2, CD72, Blimp1 B

DC-SIGN, CD209
human, mouse 19p13

high Man, Mt, CMV, EbolaV, SIV, HIV gp120, ICAM2, ICAM3 CLECT
IL13 lymph. DC

LSIGN, DCSIGNR, CD209L
human 19p13
1 high Man, EbolaV TM/CLECT

lymph. DC

SCGF
human 19q13.3

CLECT TNFa bm

CD72, Lyb2 inhibit human 9p11.2 1
CD5, SHP1, CD100 ITIM/TM/cc/CLECT PU.1
B

CD69, Leu23 induce human, mouse, rat, pig, bovine, 12p13-p12 L 1 G,Ha-Ras TM/CLECT AP1 TNFa, IL2, IL7, IL12, IL15, TCR/CD5/CD28, PMA, IFNab, IFNg, GM-CSF, Thrombin, CpG, dsRNA, estrogen, PKC, IL4, LPS, Raf1,Vav2, Ha-Ras B, T, NK

MAFA, KLRG1
human, mouse, rat, 12p12-p13

SHIP, Dok, Fc e RI, Man ITIM/TM/CLECT
MHC-I, Tg mast cell, CD8+

NKG2-(A, B), KLRC1, CD159a
human A,B 12p13

CD94, HLA-E, SHP1,2 ITIM/TM/CLECT

NK

NKG2-C, KLRC2
human, mouse 12p13.2-p12.3

DAP12 ITAM/TM/CLECT

NK

KLRC4, NKG2-(D, F), KLR
human D, F, mouse, rat(NKR-P2), pig, 12p13.2-p12.3

MICs, DAP10, DAP12, UL16, ITAM/TM/CLECT L IL2, IL4, IL5 NK, T

NKG2H, KLRC3
human E, H 12p13

?/TM/CLECT

NK

Ly-49A, KLRA1, LY49L
human, mouse 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 ,13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 12p13-p12

/TM/CLECT TCF1 B-DNA

LLT1
human 12p13

TM/CLECT

T

KLRD1, CD94 induce human 12p13

HLA-E(MHC-I), CD159a, DAP12 CLECT
IL2, IL12, IL15, IL21, TCR, androgen NK

NKR-P1A, CD161, KLRB1
human 12p13-p12

CD1d, FcRgamma TM/CLECT
IL2, IL12, IL21, TCR NK, T

dectin-1, CLECSF12
human 12p13.2-p12.3

b-glucan TM/CLECT
GM-CSF, IL4, IL10, IL13 APCs, anti-Candida

OLR1
human 12p13-p12

Ox-LDL cc/CLECT
Ye

AICL, CLECSF2
human 12p13-p12

TM/CLECT
IFNa/b, PMA NK, APCs

mincle, CLECSF9
human, mouse 12p13.32

CLECT NF-IL6 LPS, TNFa, IL6, IL13, IFNg, hsp65 ganglion

CLL1
human 12p13.2

TM/CLECT

DLEC, BDCA2, CLECSF11
human 12p13.2-p12.3

CLECT

KLRF1, NKp80
human 12p12.3-13.2

ITIMx2/TM/CLECT

NK

CLEC1
human 12p13.2

TM/cc/CLECT

CLECSF1
human 16q23

CLECT

MDL1, CLECSF5
human 7q33

DAP12 ITIM/TM/CLECT

myeloid

CLEC6, CLECSF8

human, mouse 12p13.32

TM/CLECT
NRF2

DCIR, LLIR, CLECSF6
human 12p13

ITIM/TM/CLECT
IL13 APCs

CLEC6A, CLECSF10

human
12p13

LPS, Sm

CLEC2
human 12p13

CLECT FKHR Akt

langerin/CD207
human, mouse 2p13

TM/cc/CLECT
GM-CSF, TGFb1, IL4

REG1A, PSPS
human, mouse 2p12

pancreas

REGL, PSPS2, REG I beta
human 2p12

CLECT

pancreas

REG-IV
human 1q12-q21

CLECT

pancreas

tetranectin, TNA
human, mouse 3p22-p21.3 1
sulfated PS CLECT

lung

HML2, CLECSF13
human 17p13.2

Gal/GlcNAc TM/cc/CLEST/YENF

ASGR1
human, mouse 17p13.2

asialoglycoprotein TM/CLECT

liver, preDC

ASGR2
human, rat 17p13.1

asialoglycoprotein TM/CLECT

liver, preDC

BIMLEC
human 2q24.2

CLECT/TM

APCs

chondrolectin, MT75, PRED12, CHODL
human, mouse, rat 21q11.2

CLECT/TM

testis germ cell

ManR MRC1
human, mouse 10p13

RICIN/FN2/CLECTx8/TM PPARg IL13, HCV, D3

ENDO180, MRC2
human, mouse 17q22

N-GlcNAc, MMP13 RICIN/FN2/CLECTx8/TM

DEC205, Ly75
human, mouse 2q24

RICIN/FN2/CLECTx10/TM
Fas, camptothecin
, LPS, hsp65, D3 Thy

PLA2R1
human 2q23-q24

PLA2 RICIN/FN2/CLECTx8/TM

MBL2, MBP1,
human 10q11.2-q21
L mannose CLECT TNFa, KF1B

PRG2
human 11q12

CLECT

s. muscle

PRG3, MBPH
human 11q12

CLECT
IL5
bm

anchor thrombomodulin, THBD

human, mouse, rat, rabbit, bovine, 20p11.2 1
thrombin CLECT/EGFx6/TM 1 RA, estrogen,cAMP

C1QR, C1QR1

human, mouse 20p11.21

C1q CLECT/EGFx6/TM
EV71, camptothecin

TEM1, endocialin
human, mouse 11q13

CLECT/EGFx3/TM

adipocyte

collectin PSAP, SFTP1, SPA1, SFTPA1 inhibit/ * human, mouse 10q22.2-q23.1 1
TLR2 Collagen/CLECT
NF-kB, IL-1, TTF1, DEX, cAMP, CBP/p300, SRC1

SPA2, SFTPA2
human 10q22-q23

Collagen/CLECT

CL-L1, COLEC10
human 8q23-q24.1

Collagen/CLECT

MGC3279
human 2p25.3

Collagen/CLECT

SP-D, PSP-D, SFTP4, SFTPD
human 10q22.2-q23.1 1
LPS-O, LTA, PGN Collagenx2/cc/CLECT
TTF1, NF-ATs

scavenger SRCL, CL-P1, COLEC12
human 18pter-p11.3

TM/ccx3/Collagenx2/CLECT

attractin attractin, MGCA
human 20p13 zi

EGF/CUB/EGF/Kelchx4/PSIx3/CLECTPSIx2/EGF/TM
MVA

DGCR2 DGCR2
human 22q11.21

LDL/CLECT/VWC/TM

Dm CG9134, G12111, CG15358, CG7763, CG9978, CG2839, CG15818, CG9095, Lectin-galC1-P1, Gal-lectin, lectin-21Ca, lectin-24A, lectin-24Db, lectin-28C,
Dm

Ce ZK1193.2, T03F1.10, F40G9.10,B0218.8.p, W04E12.8, W04E12.6, K02F3.5, C14A6.1, B0218.6, T19E7.1, F47C12.2, F52E1.2, C54C8.7, E03H4.10,
Ce

lectin MR60, ERGIC53, LMAN1
human, mouse, rat 18q21.3-q22

lectin/cc/TM
Sp

galectin galectin 1, LGALS1 induce human, mouse, rat, bovine, sheep, chicken, Xl, zebrafish, Dm, Ce 22q13.1
L
galectin
ErbB2, Mt, estrogen, TIMP1 epithelial, activate NF-kB

galectin 2, LGALS2, MAC2
human, mouse, rat, 22q13.1

LTa
galectin AIRE IFNa/b APCs

galectin 3, LGALS3 inhibit human, mouse, rat, rabbit, 14q21-q22 1

galectin Ets1 TNFa, HCV, TRAF2/TRAF5, TIMP1 CD71+, APCs

galectin 4, LGALS4
human, mouse 19q13.13

galectin

liver

galectin 6, Lgals6
mouse

Hoxd10
intestine

galectin 7, LGALS7
human, mouse, rat 19q13.13

galectin
Brn3a
epithelium, skin, tongue

galectin 8, PCTA1, LGALS8
human, mouse, rat 1q42-q43

galectin
CREB, AP1, LPS
APCs, B, T, NK

ecalectin, galectin 9, LGALS9
human, mouse, rat, 17q11.1

galectin
IFNa/b, IL3, IL12, HCV, staurosporine
APCs, bm,
activate NF-kB

galectin 12, LGALS12
human, mouse 11q13

galectin

adipocyte

galectin-13, PP13, PLAC8
human 19q13.1

galectin STAT4
IL12 placenta

Grifin
mouse, rat

galectin

eye

fibrinogen-related ficolin 1, FCN1
human, mouse, rat 9q34

collagen/FBG

APCs

ficolin 2, p35, L-ficolin, FCN2
human, mouse, rat 9q34

GlcNAc collagen/FBG

liver

ficolin 3, H-ficolin, Hakata antigen, FCN3
human 1p35.3

GalNAc, GlcNAc FBG

liver, lung

Saccharide Transferases

group name apoptosis species locus KO 3D structure upstream regulators memo

glycosyltransferases a(1,2), FUT1, Hh
human, mouse, rat, bovine 19q13.3 1
glycosyltransferases c-Myc endothelium, CD71+

a(1,3), FUT2, Se
human 19q13.3 L
glycosyltransferases

FUT3, Les
human 19p13.3

glycosyltransferases

a(1,3), FUT4, CD15
human, mouse, rat, bovine 11q21

glycosyltransferases
granulocytes, bm

a(1,3), FUT5
human, bovine 19q13.3

glycosyltransferases
heart

a(1,3), FUT6
human 19p13.3

glycosyltransferases
kidney

a(1,3), FUT7
human, mouse, 9q34.3

glycosyltransferases
DC

a(1,6), FUT8
human 14q24.3

glycosyltransferases

a(1,3), FUT9
human, mouse, rat, bovine 6q16

glycosyltransferases

a(1,3), FUT10
human, bovine 8p12

glycosyltransferases

MGC33202
human, mouse, rat 10q22.3

galactosyltransferase B4GALT1 enhance human, mouse, Dm, Ce 9p13 L 1 galactosyltransferases TNFa, FAK, cycloheximide

B4GALT2
human, mouse, bovine 1p34-p33

B4GALT3
human, mouse 1q21-q23

DC

B4GALT4
human, mouse 3q13.3

NK

B4GALT5
human, mouse 20q13.1-q13.2

B4GALT6
human, mouse, rat 18q11

(brain)

B4GALT7
human, mouse 5q35.2-q35.3

chondroitin synthase 1, CHSY1
human, 15q26.3

placenta

chondroitin synthase 2, CHSY2
human, 5q31.1

chondroitin beta1,4 N-acetylgalactosaminyltransferase, ChGn
human 8p21.3

thyroid

GALNACT-2
human 10q11.21

FLJ25045
human 11p15.5

FLJ40362, B4GalNac-T3

human 12p13.33

Complement and Related Proteins

group name apoptosis species KO locus structure binding partners 3D gene regulators memo

C1q C1q alpha promote human, mouse 1 1p36.3-p34.1 Collagen/C1q IG,C1q, C1s, C1r, fibronectin, PTX3
NRF2, CSV-B3, Tc heart, lung

C1q beta
human, mouse, rat
1p36.3-p34.1 Collagen/C1q

Tc heart, lung

C1q gamma
human, mouse
1p36.11 Collagen/C1q

heart, lung

C1QTNF1, GIP, CTRP1, ZSIG37
human, mouse
17q25.3 Collagen/C1q

s. muscle

C1QTNF2, CTRP2, zacrp2
human
5q33.3 Collagen/C1q

C1QTNF3, CTRP3, CORS26,
human
5p13-p12

C1QTNF4
human
11q11

brain

C1QTNF5, CTRP5
human, mouse
11q23.3

lung

C1QTNF6, CTRP6, ZACRP6
human
22q13.1

C1QTNF7, CTRP7, ZACRP7
human, mouse
4p16-p15

C1ql
mouse

brain

adiponectin, APM1, ACRP30, GBP28
human, mouse, rat
3q27 Collagen/C1q

ADD1, SREBP1c, PPARg, IL6
adipocyte

C1r C1r
human, mouse
12p13 CUB/EGF/CUB/Sushix2/Trypsin
1 NRF2, IFNa, FSH, HCV, camptothecin, ribavirin liver, adipocyte

C1s
human, mouse (& B) 1 12p13 CUB/EGF /CUB/Sushix2/Trypsin
1 TNFa, IFNg, VEGF, LPS liver, adipocyte,
cleave C2, C4

MASP1, MASP, RaRF, CRARF, PRSS5, CRARF1

human, mouse, rat 1 3q27-q28 CUB/EGF /CUB/Sushix2/Trypsin MBL

liver

MASP2
human, mouse 1 1p36.3-p36.2 CUB/EGF /CUB/Sushix2/Trypsin MBL

liver, cleave C2, C4

C1RL, C1r-like, C1rlp, LOC51279
human, mouse
12p13.31 CUB/Tripsin

STAT3, STAT5B, NF-IL6, Smads, IL1, IL6, TNFb, DEX, liver, PBL

haptoglobin, HP
human
16q22.1 CUB/Tripsin hemoglobin

liver

C2 C2
human, mouse, rat, 1 6p21.3 Sushix3/VWA/Trypsin

CD3/CD28, IL1, IFNa, IFNg liver

Factor B, BF
human, mouse, frog, zebrafish
6p21.3

liver

C3 C3
human L, d 19p13.3-p13.2 A2M/ANATO/A2M/NTR factor B, (CR1, CR2) 3d NF-kB, EWS/FLI-1, TNFa, IL1, IL13, RA, LPS, hsp65, Pg, Hp, HCV, HOXD3, GCSF, IL10, Stat4, calcineurin liver

C4a
human L 6p21.3 A2M/ANATO/A2M/NTR

p53, EV71 liver

C4b
human
6p21.3 A2M/ANATO/A2M/NTR

NF-kB, PMA, Ct liver

C5 (-) human L 9q32-q34 A2M/ANATO/A2M/NTR
5a,
liver, targets

C6 C6
human, mouse, rat, Xl L 5p13 TSP1x2/LDLa/MACPF/TSP1/Sushix2/FIMACx2

liver

C9
human, mouse, rat, rabbit, fugu
5p13 TSP1/LDLa/MACPF/TSP1/Sushix2/FIMACx2 CD59
MDP liver

C7
human, pig
5p13 /LDLa/MACPF/TSP1/Sushix2/FIMACx2

adrenal, ovary, lymph.

C8 alpha
human, rabbit
1p32 TSP1/LDLa/MACPF/TSP1 CD59

liver

C8 beta
human, mouse
1p32 TSP1/LDLa/MACPF

liver

C8g C8 gamma
human
9q34.3 Lipocalin

liver

perforin perforin, cytolysin
human, mouse, rat L 10q22 MACPF/C2 C5a,
IL2, IL4, 4-1BBL, CD30, Notch, Sd, RA, Progesterone, PKC, STATs, Ets, Sp1, CsA/FK506

C1qBP C1qBP, HABP1
human
17p13.3 MAM33 C1q,SF2

preB

7TM C3aR
human, mouse, rat 1 12pter-p13.31 7TMx2 C3a
GCSF, LPS, EV71, IL13
NK, preDC

C5R1, C5a ligand, CD88 enhance human, mouse, rat 1 19q13.3-q13.4 7TM
1 RANTES, LPS, IL6, IFNg preDC, targets

Sushi MCP, CD46
human, mouse 1 1q32 Sushix4/TM C3b, C4b, measles virus, HHV-6 gH 1
Tr1

CD35, CR1
human L 1q32 Sushix30/TM CD3b, C4b, IgG, IgD, IL2, malaria 1 IL2, IL4, IL8, TNFa, LTa, BAFF, AML1, hypoxemia, D3 induce NF-kB

DAF, CR, CD55
human 1
1q32 Sushix4 CD97, echovirus 7, EV70, CB3, LPS
FKHRL1, PMA, EV71 B, myeloid

CR2, CD21 inhibit human L 1q32 Sushix15 C3d, CD23, CD19/CD81
NF-kB, c-Myc, BAFF, Hp, Mt, Sp, Sp1, USF1 tonsil, lymphnode, B

C4BPalpha
human
1q32 Sushix8 Protein S, CD40
HNF1, androgen, NF-kB, TNFa, IL1, IL6,Galectin-7 liver, lung

C4BPbeta, C4BPB

human
1q32 Sushix3

HNF-3, NF-I, ErbB2 liver

Factor H, HF1
human
1q32 Sushix20 C3 convertases L IL10/LPS liver

FHR1, CFHL, HFL1

human
1q31-q32.1 Sushix5

liver

FHR2, HFL3
human
1q31-q32.1 Sushix4

liver

FHR3
human
1q31-q32.1 Sushix5

liver

FHR4
human
1q31-q32.1 Sushix5

liver

FHR5
human
1q22-q23 Sushix8

liver

Factor I Factor I, IF

human
4q25 KAZAL/SR/LDLax2/Trypsin

liver

LU CD59, protectin, MIC11
human, mouse, rat, rabbit, viruses L 11p13 LU CD2, C8alpha, C9, Hp L p53, TNFa, CREB, STRA13, androgen, PMA, Tprim., IFNa,PDGF,

ARS, component B

8q24.3 LU

tongue

E48, LY6D

human
8q24-qter LU

Hoxc8, Hp
, D3
tongue

PSCA
human
8q24.2 LU

PMA prostate

G6C
human
6 LU

G6E
human
6p21.3 LU

SLURP-2, LYNX1
human
8q24.3 LU

Antibacterial peptides (partial list)

group name species locus KO gene 3D gene regulators memo

a defensin a1/HNP-1, DEFA1
human 8p23.2-p23.1

C/EBP, c-Myb,Nef, TCR/CD3/CD28, IL15, RA, Nod2
neutrophil, processed by matrilysin

a3/HNP-3, DEFA3 human, 8pter-p23.3

IFNa neutrophil

a4/Def.4,,DEFA4 human 8p23

IFNa
neutrophil

a5/Def.5, HD-5, DEFA5
human 8pter-p21

neutrophil

a6/Def. 6, DEFA6 human 8pter-p21

neutrophil

b defensin b1, DEFB1
human 8p23.2-p23.1

kidney, liver, prostate, salivary gland, constitutive

b2, hBD-2, DEFB4, SAP1, DEFB102 human 8p23.1-p22
1 L bacteria, Hp, LPS, FliC,NF-kB,IL-1, IL17, TNFa salibarygland, kidney, tongue

DEFB103A, HBD3, HBP3, DEFB3, HBD-3, HBP-3, human 8p23

corticosteroids

DEFB104, DEFB4, DEFB-4
human
8p23

DEFB105, BD-5, DEFB-5
human
8

DEFB106, BD-6, DEFB-6
human
8p23-p22

DEFB107, DefB-7
human 8p23-p22

DEFB108, DefB-8
human 8p23-p22

SPAG11, EP2, HE2, EP2C, EP2D human 8p23-p22

DEFQ1, Def-theta1
human
8p23.1

bone marrow, lymph node, thyroid

DEFB118, ESC42, DEFB-18
human
20q11.1-q11.22

testis

DEFB119, DEFB-19, DEFB-20, DEFB120
human
20q11.1

testis

DEFB123, DefB-23
human
20q11.1

DEFB124
human
20q11.1

testis

DEFB125
human
20p13

DEFB126
human
20p13

testis

DEFB127
human
20p13

DEFB129
human
20p13

UNQ827, KFLL827, DEFB32
human
20p13

cathelicidin cathelicidin, FALL39, CAP18, CAMP
human,mouse 3p21.3

1 St, LPS, IFNa, IL5, IL-6, RA bone marrow, PMN, processed by proteinase-3

hepcidin hepcidin, HAMP, LEAP1 human, mouse 19q13 1
1 iron, C/EBPa, USF2, hypoxia liver

Tandem gene information; 6p21[b110-114] 20p13[b125>b26(ESP13)>b127>b129] [], 8p23 [b1<a6<a4<a1<T1<SPAG11<b104<b106<BD5], 20p13[b125>b26(ESP13)>b127>b129], 20q11.1[b118><b119<b122, b123><b124]

One-line review of

Antimicrobial peptides of vertebrates by Yang et al. (Annu Rev Immunol 2004), by Ganz & Lehrer (Curr Opin Immunol 1998)

IL8 Family Chemokines and Their Receptors

group proposed name ligand/receptor apoptosis species gene locus KO 3D gene regulators memo

CC SCYA1 I309, CCL1
CCR8
human, mouse
17p13.2
1 TCR, IL12, IFNa, IL31

CCL2 MCP1, MCAF, SCYA2 CCR2 inhibit human, mouse, rat, bovine, rabbit,pig,dog, 1 17q11.2-q21.1 L 1 NF-kB, Sp1, C/EBPs, AP1, EGR1, Bcl6, PDX1, Hoxc8, NRF2, EWS/FLI-1, TNFa, LTa, TRAIL, Fas, RANKL, IL1, IL4, IL13, IL17, IFNa, IFNg, GM-CSF, IL1b/IFNg,IFNk, PDGF-BB, RA, PMA, AgII, C5a, EP4, VIP, PACAP, insulin, Resistin, estrogens, Wnt1, Akt/PKB, IKKs, p38, PLC, LPS, BLP, LTA, PGN, KF1B, MDP, OX-CA, Bm, Ec, St, Sa, Lm, Mt, Pg, Tc, TBhsp70, BCGhsp65, flagellin, BCG, Cp,Hp, Pa, Tg, dsRNA, HCV, RSV, AdV, HHV8, UVB, shear stress, RANTES, SCF, VEGF, plasmin, p38, Cannabinoid, doxorubicin, Alprazolam, Bmp6, Bmp7, estrogen, PGE2, Gab2, EP4, BMP2, IL10, AgII, IKKs, SOCS1

CCL3 MIP1a, LD78, SCYA3 CCR1, 5 inhibit/promote human, mosue, rat, chicken
17q11-q21 L 1 NF-kB, C/EBPs, Ets2, p53, PPARg, IL3, IL2, IL6, IL15, GM-CSF, Ets, serum, TNF, FasL, Fas, RANKL, CD40, IFNk, XNA,VIP, PACAP, LPS, PGN, MDP, TBhsp70, LTA, b-glucan, BCGhsp65, BCG, Ec, Ld, Lm, Ma, Mt, Sa, Sm, St, g-irrad, NO., PMA, FceRI, CD3/28, BCR, CD43,Nef, CD3&IL2, Bcl6, RANTES, RA, D3, PGE2, Rac2, AmB, camptothecin, ribavirin

CCL3L1 LD78-beta

human
17q11.2

PMA

CCL4 MIP1b, ACT2, LAG1, SCYA4 CCR5 promote human, mouse, rat, rabbit
17q21
L CREB, LPS, CD40, TNF, RANKL, FasL, IL1, IL3, IL10, IL2, IL12, IL15, IL31, GM-CSF TCR/CD3/CD8/CD28, BCR, XNA, PMA, CD43, MIP3, Subst.P, CD3&IL2, MDP, flagellin, b-glucan, BLP, Bm,,Hi, Ld, Lm, Ma, Mt, Sa, Sp, g-irrad., HCV, Nef, dsRNA, CpG, OX-CA, Cannabinoid, CsA, estrogen, RANTES, SCF, D3, PGE2, AmB, ribavirin

CCL4L1
LAG1, LAG-1, SCYA4L, AT744.2

human

17q12

CCL5 RANTES, SCYA5 CCR1,3,5 inhibit/promote human, mouse,rat, bovine 1 17q11.2-q12 1 L NF-kB, IRF1, IRF3, IRF7, AP1, AIRE, RFLAT1, HSF1, IL1, IL2, IL17, TNF, CD40, CD8/28, LTa, RANKL, IFNs, IL12, TCR, M-CSF, GM-CSF, VIP, PACAP, LPS, PGN, MDP, LTA, Bm, Hp, Ld, Lm, Mt, Tg, Ct, Ma, Mt, Pg, Yp, dsRNA, EV71, VLP, CD28, BCR, IFNg, IL17, SCF, EP4, BRCA1, PMA, RSV, IKKs, IKKi, TBK1, TAK1, JNK, CFTR, DEX, estrogen, androgen, D3, EP4, IKKs targets

CCL6 c10, MRP-1, SCYA6

mouse

Hf ,Sm

CCL7 MCP3, SCYA7 CCR1,2,3
human, mouse,rat
17q11.2-q12
L NF-kB, Hoxc8, b1-integrin, b-catenin, TRAIL, IL1, IL17, TNFa, RANKL, VEGF, PMA, Bcl6, insulin, NO, BLP, Bm, Ld,, Lm, Mt, Pg, Sp, Tg, VLP, DEX, BMP2, IL10, IKKs, camptothecin, cantharidin, ALA, SOCS1

CCL8 MCP2, SCYA8 CCR3
human,mouse, pig,bovine
17q11.2
1 IFNg, IL1, RANKL, LPS, PGN, Lm, Mt, Tg, VLP

CCL9 MIP-1 gamma, SCYA9

mouse

NF-kB, NRF2, PPARg, AIRE, TNF, RANKL, IL1, LPS, D3

CCL11 eotaxin 1, AI1, SCYA11 CCR3
human, mouse, rat, pig, house,bovine
17q21.1-q21.2 L L NF-kB, STAT6, IL13, TNFa, IL1b, IFNg, IL4, IL9, IL25, LPS, PGN, LTA, Lm, Mt, VLP, glucocorticoid, TGFb1, estrogen, HuR, A2aR

CCL12 MCP5, eae7, TCA-3, SCYA12

mouse

LPS, CpG, Lm, IFNabR1, TRIF

CCL13 MCP4, NCC1, SCYA13 CCR2,3
human
17q11.2

TNFa,TRAIL, IFNg, IL4, PGN, glucocorticoid, RA

CCL14 NCC2, SCYA14 CCR1
human
17q11.2
1 IFNa, TNFa, c-Myc, IL1,ALK1, TGFR1

CCL15 MIP1d, NCC3, leukotactin, MIP5, SCYA15 CCR1,3
human
17q11.2

ALA

CCL16 NCC4, SCYA16 CCR1
human
17q11.2

SCF

CCL17 TARC, SCYA17 CCR4
human, mouse
16q13

TNFa, IFNg, IL10, IL25, IL31, SCF,LPS, Lm, Mt, Tg, BMP2

CCL18 PARC, AMAC1, DC-CK1, SCYA18

human
17q11.2

IL10, D3, TCR/CD3, LPS, Ca,Mt, Sa, influenza v, TNFa, CD40L,IFNg,

CCL19 MIP3b, exodus-3, CCL19, ELC, SCYA19 CCR7
human, mouse
9p13

IL31, Ma, LPS

CCL20 MIP3a, exodus-1, CCL20, Larc, SCYA20 CCR8
human, mouse, rat
2q33-q37

NF-kB, Sp1, ESE1, EWS/FLI-1, IL1, TNFa, LTb, PMA, LPS, PGN, Bm, Ld, Lm, Mt, Tg, Ye, flagellin, UVB, hypoxia, D3, MEK1, camptothecin, ALA

CCL21 SLC, exodus-2, SCYA21 CCR7 inhibit human, mouse(a,b,c)
9p13

SCF, Prox1, PMA

CCL22 MDC, STCP-1, SCYA22 CCR4
human, mouse
16q13

IL1b, SCF, IL12, IL13, IL31

CCL23 MPIF1, Ckb-8, SCYA23 CCR1
human
17p13.2
1 IL31, Mt, LPS

CCL24 eotaxin 2, MPIF2, SCYA24 CCR3
human, mouse
7q11.23
L LPS, IL-4

CCL25 Teck, SCYA25 CCR9 inhibit human, mouse
19p13.2

VDR, Egr1, AIRE

CCL26 eotaxin 3, SCYA26 CCR3
human
7q11.2

STAT6,IL4, IL13, TGFb

CCL27 CTACK, ILC, ALP, Eskine CCR10
human, mouse
9p13

TNFa, NRF2, PMA

CCL28 CCL28 CCR3, CCR10
human, mouse
5

CXC CXCL1 Groa, Gro1, MGSA, SCYB1, KC
CXCR2
human, mouse
4q12-q13
1 NF-kB, NF-IL6, Sp1, HMG-I, C/EBP, PPARg, EWS/FLI-1, TRAIL, TNFa, IL1, IL17, IL31, XNA, VEGF, insulin, LPS, PGN, KF1B, MDP, BLP, LTA, Ec, Ld, Lm, LLO, Mt, Pg, St, Sa, Tg, Ye, hsp70, hsp65, flagellin, BCG, AdV, UVB, HHV8, VLP, BMP2, IL10, Wnt3a,

CXCL2 MIP2, MIP2a, Grob, Gro2, SCYB2 CXCR2
human, mouse
4q12-q13
1 NF-kB, c-Myc, PPARg, EWS/FLI-1, IL1, IL17, TNFa, FasL, RANKL, XNA, PMA, C5a, GM-CSF, LPS, BLP, PGN, KF1B, MDP, LTA, R848, Bm, Cd, Ct, Ec, Hp, Ma, Mt, Ld, Lm, Pg, Sa, Sd, St, Tg, Ye, flagellin, HCV, RSV, dsRNA, VLP, FVIIa, DEX, NO, hypoxia, Subst.P, VIP, PACAP, UVB, estrogen

CXCL3 MIP2b, Grog, SCYB3 CXCR2
human
4q21

IL1, TNFa, LPS, PGN, MDP, LTA, Bm, Hp, Ld, Lm, Mt, St, Tg, Ye, flagellin, HHV8, UVB, DEX, D3

CXCL4 PF4, SCYB4
inhibit human, mouse

4q12-q13

Ets1, GATA1, PDX1, IL6

PF4V1
PF4A, CXCL4V1, PF4-ALT, SCYB4V1

human

4q12-q21

CXCL5 ENA78, SCYB5, LIX
CXCR2
human, mouse

4q12-q13

AIRE, GCSF, IL1, IL17, TNF, BMP2, LPS, hsp65, Hp, Hf, Mt, Pg, VLP
induces NF-kB

CXCL6 GCP2, SCYB6 CXCR1,2
human
4q12-q13

EWS/FLI-1, IL1, TNFa, BAFF, IFNg, PGN, DEX

CXCL7 proPBP, CXCL7, (CTAP3, TGb, NAP2, TC1, TC2), SCYB7, PPBP CXCR2
human, mouse

4q12-q13

PU.1, IL1b/TNFa, Pg

CXCL8 IL8, see ILs CXCR1, 2

PGN, IL1

CXCL9 MIG, SCYB9 CXCR3
human, mouse

4q21

STAT1, NF-kB, CBP, IFNg, B-DNA, PPARg, TNF, EP4, IL12, IL10, Hf, Hp, Lm, Mt, Pg, Tc, Tg

CXCL10, SCYB10 IP10, INP10, Mob1 CXCR3 (-) human, mouse
4q21 L
NF-kB, Hoxc8, IL1, TNF, LTa, Fas, IFNa, IFNb, IFNg, IL4, VEGF, Subst.P, EP4, cholecystokinin, CpG, LPS, BLP, Ec, Pg, St, Sa, Lm, Mt, Tg, TBhsp70, BCGhsp65, BCG, dsRNA, HCV, MV, AdV, HHV8, VLP, PGE2, estrogen, STAT1, PPARg1, IFNabR1, TRIF, MyD88

CXCL11 IP9, ITAC, CXCL11, SCYB11 CXCR3
human
4q21.2

TNFa, IFNa/b, IFNg, PPARg, LPS, B-DNA, Mt, Tg, TRIF

CXCL12 SDF1, pre-B, CXCL12, SCYB12 CXCR4 induce/inhibit human
10q11.1 L L NF-kB, TNFa, CD8/28, Wnt1, Hf, Hi, VLP, IL3, ER, PTEN, IKKs, estrogen targets

CXCL13 BLC, BCA1, CXCL13, SCYB13 CXCR5
human
4q21 L
A2aR, LPS, Hp, IL10

CXCL14 BRAK, SCYB14

human, mouse
5q31

AIRE, HCV, estrogen

CXCL15 Lungkine

mouse

1

CXCL16 SRPSOX CXCR6
human, mouse
17p13

PGN, IFNg, TNFa, Pg
induce NFkB

XCL1, SCYC1 XCL1, SCM1, SCM1a, lymphotactin XCR1 promote human, mouse
1q21-q25

CsA/FK506, CD3&IL2, PMA, VLP, Pg, androgen

XCL2, SCYC2 XCL2, SCM1b XCR1
human
1q23

CX3CL
CX3CL1, SCYD1 Fractalkine, Neurotactin (NTN) CX3CR1
human, mouse, rat
16q13

NF-kB, NRF2, PDX1, IL1, IFNg, TNFa, SCF, FSH, St, flagellin, EP4, IKKs, androgen

CCR (7TM) CCR1 CKR1, HM145, CMKBR1 CCL3, 5, 7, 14, 15 ,16 ,23
human, mouse
3p21 L
NF-kB, ARNT2, TNFa, RANKL, IFNa/b, IFNg, IL-2, IL5, IL6, IL8, PMA, IL15, LPS, b-glucan, Lm, CD3/28, RANTES, IL10, D3, ErbB4 APCs

(G-coupled) CCR2 CKR2, CMKBR2 CCL2(MCP1), 12,13, (inhibit) human, mouse
3p21 L
IL2, IL15, IFNa, RANKL, Lm, Tc, NF-kB, PMA,GCSF, SCF, estrogen, D3
APCs

CCR3 CKR3, CMKBR3 CCL5(RANTES), 6, 8, 11, 13, 15, 24, 26
human, mouse
3p21.3 1
IFNg, IL2, IL3, IL4, IL25, estrogen eosinophil

CCR4 CKR4, CMKBR4 CCL17, 22(Tarc, MDC)
human, mouse
3p24 L
BCR, IL18, G-CSF

CCR5 CCCKR5, CKR5, CD195 CCL3, 4, 5 (MCP2, MIP1a, MIP1b)
mediate human,mouse
3p21 L
NRF2, TNFa, IL6, IL12, TCR, PMA, BCR, Lyn, IFNg, M-CSF, Tc, EV71, IL10, D3, Rac2, rapamycin
APCs/T, HIV-1 coreceptor

CCR6 CKRL3/GPR29/GPRCY4/STRL22/CMKBR6 CCL20(MIP3a,)
human, mouse
6q27 1
AIRE, IL10, IL4, IFNg, LPS, MDP, hypoxia/CD3 B, Sd

CCR7 EBI1, CMKBR7, CD197 CCL21 inhibit
human, mouse
17q12-q21.2 L
NF-kB, IL18, Notch, LPS, Bm, Ld, Lm, Mt, Tg, VLP, PMA, DAP12, TREM2, estrogen, D3
B/T

CCR8 CKRL1/CMKBR8/CMKBRL2 CCL22 (Tarc, MIP1b)

human, mouse
3p22 L

CCR9 GPR-9-6, CCBP2
CCL25 inhibit human, mouse
3p21.3 L
TNFa
TECK

CCRL1 CCRL1, PPR1

human, mouse

3q22

CCRL2 CCRL2, HCR, CKRX, CRAM-A

human, mouse

3p21

G-CSF, D3 CD71+

CXCR (7TM) CXCR1 IL8R1, IL8Ra CXCL6, 8
human
2q35

NF-AT, NF-kB, PU.1, IL2, IL15, Subst.P, D3, IFNa neutrophil

CXCR2 IL8R2, IL8Rb CXCL1,2,3,5,6,7,8
human, mouse
2q35 L
Fas, camptothecin neutrophil

CXCR3 GPR9, CD183 CXCL9, 10, 11,
human, mouse

8p12-p11.2 L
SCF, ribavirin, TCR
mDC

CXCR4 Fusin,NPY3R, D2S201E, LESTR, HM89, LAP3, CD184 CXCL12 (SDF1)
inhibit human, mouse
2q21 L
NF-kB, USFs, c-Myc, YY1, CD40, , TCR/CD3, Tprim, BCR, PMA, LPS, Bm, Ld, Lm, Mt, Tg, Ma, IL2, IL4, IL7, IL13, IL15, VEGF, ALK1, BMP2, L-selectin, cAMP B/T/NK/mDC

CXCR5 BLR1 CXCL13
human, mouse
11 L
SCF, TNFa, IFNg B, HIV coreceptor

CXCR6 Bonzo, STRL33 CXCL16
human, mouse
3p21 1
HCV

CX3CR
CX3CR1
V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1
CX3CL1

human, mouse

3p21

TNFa
NK

XCR XCR1 GPR5/lymphotaxin receptor XCL1, 2
human, mouse

3p21.3

Tandem gene information:

17q12; CCL2>CCL7>CCL11>CCL8>CCL13>CCL1>>>>CCL5>CCL16>CCL14>CCL23>CCL18>CCL3>CCL4>>CCL3L1>CCL4L>>CCL3L1>CCL4L
4q13.3; IL8>CXCL6>PF4V1>CXCL1>PF4>CXCL5>CXCL3>>CXCL2

One-line review of

Chemokines by Cysterby(Science 1999), Melchers et al. (Cell 1999), Rossi & Zlotnik (Annu. Rev. Immunol. 2000)

Inducible Proteins for Immunity

response
name species locus KO apoptosis domain structure 3D binding partners gene regulators memo

viral TPR

IFI56, IFIT1, G10P1, RNM561, GARG-39
human 10q23.3

TPRs

IFNa, IFNb, IFNg(-), BRCA1,IRF3, PLZF, BLP, HCV, TNFa, TRAIL, Fas, FSH, LPS, LTA, B-DNA, Bm, Hp, Ld, Lm, Mt, Tg, dsRNA, VLP, (p38), ER, ribavirin, SOCS1

IFI54, IFIT2, G10P2, GARG-16
human 10q23.3

TPRs

AIRE, IFNa, EP4, LPS, LTA, B-DNA, Ct, Bm, Ld, Lm,Mt, Tg, VLP, IRF3, (p38), SOCS1

IFIT3, IRG2, IFI60, IFIT4, ISG60, RIG-G, CIG-49, GARG-49 human 10q24

TPRs

Hp, VLP, B-DNA, SOCS1

RIG-G, IFI60, IFIT4 human 10q24

TPRs

LPS, Lm, Mt, Tc, Tg, IFNa, IFNb, TNFa, IRF3, (p38), glucose, HCV

IFIT5, RI58
human
10q23.3

IFNa, LPS

OIAS 2',5'-oligoadenylate synthetase, OIAS, OAS1 human, mouse 12q24.2
induce OAS 1
PLZF, TNFa, IFNa, IFNb, IFNg(-), LPS, Sm, HCV, tributyltin 2-5As actiavates RNase L

OAS2 human 12q24.2

IFNa/b, TNFa, LPS, Mt, Tg, HHV8, IL12, TGFb, SOCS1

OAS3, p100 human 12q24.2

IFN, TNFa

TRIP14, OASL human 12q24.2

OAS/Ub x2

IFNa, TNFa, Bm,Ld, Lm, Mt, Tg, DV

Exonuc. ISG20, HEM45 human 15q26

Exonuclease

IFNa, IFNb, IL13, LPS, LTA, Bm, Ld, Lm, Mt, Tg, estrogen, TRIF, SOCS1

ABC RING4, TAP1 human 6p21.3 L
ABC transporter

CIITA, IFNa, b, g, dsDNA,HCV, dsRNA, Hp, Hf, UVB

TM IFI17, IFI9-27, IFITM1 human, bovine 11p15.5

TMs

IFNa, b ,g, BRCA1, TNFa, TRAIL, LPS, Ct, Bm,Lm, Mt, Tg, Bcl6, DAC/TSA, PMA, IL15, EBV, ribavirin, anti-viral

IFITM2, IFI1-8D human 11p15.5

TMs

IFNs, Ets1

IFITM3, IFI1-8U human, mouse(fragilis), rat, bovine, 11p15.5

IFNa, LPS, Lm, Mt, Tg, TRIF

FAM14 IFI6-16 human 1p35

singal/TM

IFNa, IFNb, IFNg(-), HCV, TNFa,TRAIL, Fas, N-Myc,ribavirin, Ets1

IFI27, ISG12 human 14q32

EWS/FLI-1, IFNa/b, VEGF, MVA

FAM14A human 14q32.2

FAM14B human 14q32.2

INDO INDO, indole 2,3-dioxygenase human 8p12-p11
enhance /inhibit

IL1, IL12, IL18, TNFa, IFNa,b, IFNg, LPS, MDP, ssRNA, Bm, Ld,Mt, Tg, VLP; NO
Trp to L-kynurenine

Mx
MxA, IFI78, MX1 human, mouse, rat, pig, sheep, bovine, dog, chicken, duck, trout, zebrafish, fugu 21q22.3
enhance Dynamin/GED m
IFNa, IFNb, IFNk, IFNg(-), IL2, BRCA1, LPS, LTA, Mt, Lm, dsRNA, B-DNA, HCV, DV, HHV8, (p38), ribavirin, TRIF

MxB human, mouse, bovine, salmon 21q22.3

Dynamin/GED

IFNa, IFNb, IFNg(-), HCV, TRAIL, LPS, LTA, hsp65, Ld, Lm, Mt, Tg, TRIF

IFI20x

IFI16, p202, p204 (mouse) human 1q22 SLE enhance /inhibit Pyrin/HINx2
Rb, BRCA1, 53BP1, CBFA1, NF-kB, p202 IFNa,b,g, HCV, TRAIL, Fas, IL5, IL6, IL12, LPS, B-DNA, hsp65, Tc, VLP, BMPs, HOXD3, DEX, p53, BMP2, TRIF, SOCS1
systemic lupus

MNDA human 1q22

Pyrin/HINx2

AIM2 human 1q22
enhance Pyrin/HINx2

IFNa/b

secret IFI30, IP-30, GILT human 19p13.1

signal

IFNa,b,g, TNFa, EBV, AmB, Wnt3a

PPM IFI35, IFP35 human 17q21

PPM

PLZF, IFNa,b,g, FSH, LPS, IL15, DEX

SP110, IFI41, IFI75 human 2q37.1

SAND

IFNa, b, IFNg

GBP GBP1 human

GBP

IFNa, TNFa, dsRNA, B-DNA, LPS,MDP

GBP2 human 1pter-p13.2

GBP

IFNa,b,IFNg, SOCS1

TLCd IFI44, p44, MTAP44 human 1p31.1

TLCd

IFNa, b, IRF3, LPS, B-DNA, HCV

C1orf29, GS3686 human 1p31.1

IFNa/b, CIITA

TTF TTF2 human 1p22

DEXD/helicase

IFNa transcriptional termination

crystallin AIM1 human 6q21

crystallinx6/ricin

ALK1, MITF, PLZF, E2F, GR, FSH, HHV8

Elp3 CIG5 human 2p25.2

Elp3

IFNa, IFNb

HD SAMHD1, DCIP human 20pter-q12

SAM/HD

IFNa/b, IFNg

hORC2L human 2q33

Pa,

Tristetraproline(TTP)/ZFP36 human 19q13.1 1
EZF

Pa, St, mitogens, Sp1, CD3/28,FVIIa destabilize TNFa mRNA

BRF1, ERF1, cMG1, ERF-1, Berg36, TIS11B, RNF162B, ZFP36L1
human
14q22-q24
1
inhibit?
Tis11b_C/CCCHx2

IL-4, Ca2+

PBEF human, mouse, rat, 7q22.1-7q31.33

TNFa, PMA, BAFF, LPS, Bm, Ld, Lm, Mt, Tg, MDP, NO,

NOS

iNOS/NOS2/NOS2A human, mouse, rat, guinea pig, dog, horse, carp 17q11.2-q12 L enhance/inhibit
L
NF-kB, NRF, IRF1, C/EBPbeta, ATF2,Oct-1, Brn-3, RXR, PPARg, Elk3, STAT1, KLF6, p300, IL1b, IL13, IL15, IFNg, IFNb, somatostatin, Subst.P, LPS, MDP, sBLP, flagellin, St, Sd,HBx, O stress, shear stress, heat shock, hypoxia, PMA, progesterone, estradiol, DEX, D3, melatonin, NO,IL-4, Galpha13,PKCe, RON, Jak2, PI3K, p38, TGFb, IL10

NOS II/NOS2B human 17p13.1-q25

eNOS/NOS3 human, mouse, guinea pig, bovine, pig, 7q36 L

Sp1, GATA-2, IL10, TNFa, PI3Kg, Jak2, MEK1, ERK1,2

nNOS, NOS1 human, mouse, rat, rabbit, dog, fugu, zebrafish 12q24.2-q24.31 L

1
CREB, Oct-2, AgII

ROS
SOD2
human

TNFa

HB-EGF HB-EGF/diphtheria toxin receptor(DTR)/DTS human,mouse, rat 5q23 L inhibit/induce signal/EGF-TM 1
AP1, v-Jun, p53,RARalpha, Cp, Hp, TNFa, IL1, PMA,GM-CSF, VEGF, gastrin, PAF, AGII, Thrombin, H2O2, stretch, shear stress, UVB, lysophospholipid, estradiol, progesterone, B-Raf, Raf-1, Ras, mitogen binding to EGFR, inhibit NF-kB

HGF HGF, hepatopoietin A , scatter factor human 7q21.1 L inhibit/induce PAN/kringlex4/trypsin
c-Met(HGFR) LPS, MDP, Ma, St, IL1, TNFa, IFNg, AP2, C/EBPs, Sp1, Sp3, USF, Stat3, DEX, ER, TGFb1,c-Src, liver

D2S448 D2S448 human

LRRs/IGx4/perioxidase/VWC

Ct

G0s2 G0s2 human 1q32.2-q41

secreted

LPS, MDP, LTA

MIF
MIF human, mouse 22q11.2 L induce, inhibit MIF 1
LPS, polyIgA, CD3/28/TCR, VLP, thrombin, FXa, hypoxia, glucocorticoid, insulin, hypoxia, glucose, UV-B, VitE, estrogen

D-dopachrome tautomerase, DDT human, mouse, rat 22q11.2

MIF

MARCKS
MacMARCKS
human

MARCKS

Ca, CaM, PKCs
LPS,

GCH1 GCH1, GTP cyclohydrolase 1 human 14q22.1-q22.2

LPS,MDP

LITAF PIG7, LITAF human 16p13.3-p12

LITAF

A-Myb,B-Myb, p53, LPS, APC, cantharidin, calcineurin activate NF-kB

pentraxin

PTX3 human 3q25 1 (clearance) PTX
bacteria NF-kB, E2F, EWS/FLI-1, IL1b, TNFa, CD43, IFNg, LPS, MDP, LTA anti-bacterial/fungal

SAP, APCS human 1q21-q23 1

CRP human 1q21-q23

PTX

neuronal pentraxin I, NPTX1 human 17q25.1-q25.2

PTX
taipoxin KCl

neuronal pentraxin receptor, NPTXR human 22q13.1

PTX

neuronal pentraxin I, NPTX1 human 9q31-q32

Sushix3/HYRx2/Sushi/TNFR/EGFx6

ADPrc
CD38
human
4p15
1

LPS, hsp65, TIMP1

GTPase IGTP
mouse

IFNa/b, IFNg, B-DNA, Lm, LTA, SOCS1

GTPI
mouse

IFNa/b, IFNg, Lm, LTA, SOCS1

cAMP/cGMP cleavage GCH1, GCH, DYT5, GTPCH1
human
14q22.1-q22.2
hph1

LPS
cGMP

PDE4B
human

LPS, Lm, IL10
cAMP

CD87
CD87, UPAR, URKR
human
19q13

IFNa

IFRD
IFRD1, PC4, TIS7
human, rat, chicken, frog, zebrafish, fugu, fly, Ce, At, Nc, An
7q22-q31

IFRD/IFRD-C

IFNa

SM15, IFNRP, SKMc15
human, mouse, rat,
3p21.3

IFRD/IFRD-C

LSP1
LSP1
human
11p15.5

caldesmon-C

IFNa

LENG4
LENG4, BB1
human
19q13.4

TMx2/MBOAT /TM

IFNa

CRISP
CRISP1
human
6p21.1-p21.2

LPS
thyroid

FIZZ
FIZZ3, resistin (RETN)
human
19p13.2

RETN

neutrophils

TGTP

human

B-DNA

TNF SA Serum amyloid A3 human

TNFa, IKKs

PAI2, PLANH2, Serpin B2, SERPINB2 human 18q21.3

Serpin

TNFa,IKKs

epiregulin human 4q13.3

NF-kB, TNFa, IKKs

DUF758
TNFAIP8, GG2-1, SCC-S2, MDC-3.13
human

inhibit
DUF758 (without DED)

TNFa, ALA

SEC6 TNFAIP2, B94 human, mouse, 14q32

SEC6

NF-kB, TNFa, IL1, MDP, Ma, Bm, Ld, Lm, Mt, Tc, Tg

XTP7 human 19q13.32

SEC6

HBx

SEC6 human, mouse, rat,zebrafish, fly, Ce, Sc 5p15.33

SEC6

LOC283849 human 16q22.1

SEC6

AngII
Osteopontin human, mouse, rat, chick, bovine, rabbit,J.quail, 4q21-q25 L inhibit Osteopontin/TM
alphavbeta(3) integrin Oct1, Oct4, Sox2, Ets1, Hoxa-9, c-Myc, USF, AP-1, Egr1, p53, CBFA, TGFb, PTHrP, PDGF, HGF,AgII, LIF, IL6, M-CSF, IL1, PMA, FGF1, D3, ER, estrogen, progesterone,glucocorticoid, RA, ischemia,alendronate, glucose

ErbB4
ZCWPW1, FLJ10057 human 7q22.1

cc/PWWP

ErbB4

Prostaglandin
NOV
NOV
human
8q24.1

IB/VWC/TSP1/CT

EP4

IL13
SPRR
SPRR1a
human
1q21-q22

Cornifin

STAT6, IL4, IL13
tangue, tonsil, bradder

SPRR2A
human
1q21-q22

STAT6, IL4, IL13
bradder, guts

SPRR2B
human
1q21-q22

STAT6, IL4, IL13

For ISG15, & RAP36, see Ub family

Microarray/proteomics analysis of

infection by bacterium Chlamydia pneumoniae(intracellular, Gram negative)

Chlamydia trachomatis

Enteropathogenic Escherichia coli (intracellular, Gram negative)

Helicobacter pylori(intracellular, Gram negative)

nontypeable Haemophilus influenzae

Listeria monocytogenes (intracellular, Gram positive)

Mycobacterium avium (intracellular)

Mycobacterium tuberculosis(intracellular)

Neisseria meningitidis

Neisseria gonorrhoeae

Pseudomonas aeruginosa(intracellular, Gram negative)

Salmonella typhimurium(intracellular, Gram negative)

Salmonella dublin (intracellular, Gram negative)

Streptococcus pneumoniae (Gram positive)

Yersinia enterocolitica

Yersinia pseudotuberculosis

protozoa Leishmania donovani (intracellular)

Leishmania major

Schistosoma mansoni

Trypanosoma cruzi

Toxoplasma gondii(intracellular)

helminth Brugia malayi

virus Adenovirus

Avian Pneumovirus

Coxsackievirus B3(ssRNA, enterovirus)

dengue virus

Hepatitis C Virus(ssRNA, hepacivirus), HCV vs HBV

HIV-1(retrovirus)

Herpes simplex virus(dsDNA, HV)

human herpes virus 8

Marej's disease virus(dsDNA, HV)

Modified vaccinia virus Ankara (ds DNA, MVA)

Epstein-barr virus

Papillomavirus 11(dsDNA, PV)

Papillomavirus type 16 E6

Respiratory syncytial virus

simian immunodeficiency virus

by pathogen components Hepatitis B virus x protein

KF1B (Nod1 ligand)

LPS (TLR4 ligand), sBLP (TLR2 ligand), MDP(Nod2 ligand), CpG (TLR9 ligand), flagellin (TLR5 ligand)

ds RNA (TLR3/CIAS1 ligand), ds B-DNA

with general staffs gram neg. & pos. bacteria, virus, PAMPs in macrophages

Review
Signatures of the Immune Response (Shaffer et al., Cell 2001)

Review of

Inohara N, Nunez G. " ML- a conserved domain involved in innate immunity and lipid metabolism " Trends Biochem Sci 2002 27, 219-221
Alloresponses by Lechler et al. (Nat Rev Immunol 2003), Parham & McQueen (Nat Rev Immunol 2003)
B7/CD28 by Salomon & Bluestone (Annu Rev Immunol 2001), Sharpe & Freeman (Nat Rev Immunol 2002)
B cell development by Hardy & Hayakawa (Annu Rev Immunol 2001)
B cell development & transcription by Busslinger (Annu Rev Immunol 2004)
B cell activation by Niiro & Clark (Nat Rev Immunol 2002)
Bare lymphocyte syndrome and the regulation of MHC expression. by Reith & Mach (Annu Rev Immunol 2001)
C-type lectin by Geijtenbeek et al. (Annu Rev Immunol 2004)
CD1 signaling by Brigl & Brenner (Annu Rev Immunol 2004), by Moody & Porcelli (Nat Rev Immunol 2003)
CD45 by Hermiston et al. (Annu Rev Immunol 2003)
Chemokines by Rot & Andrian (Annu Rev Immunol 2004), by Yoshie & Zlotnik (Immunity 2000)
Cytotoxic T lymphocytes by Barry & Bleackley (Nat Rev Immunol 2002)
Dendritic Cells by Banchereau et al. (Annu. Rev. Immunol. 2000), Shortman & Liu (Nat Rev Immunol 2002)
FcRs by Ravetch & Bolland (Annu Rev Immunol 2001), Kawakami & Galli (Nat Rev Immunol 2002), Takai (Nat Rev Immunol 2002)
Glucocorticoids in T Cell Development and Function by Ashwell (Annu Rev Immunol 2000)
IgA by Fagarasan & Honjo (Nat Rev Immunol 2003)
IgE switching by Geha et al. (Nat Rev Immunol 2003)
Innate Immunity by Hoffmann et al. (Science 1999)
Integrin by Pribila et al. (Annu Rev Immunol 2004)
KIR by Vilches & Parham. (Annu Rev Immunol 2002), Natarajan et al. (Annu Rev Immunol 2002)
L-selectin ligands by Rosen (Annu Rev Immunol 2004)
MHC Class Ib Molecule, Qa-1 by Jiang & Chess (Annu. Rev. Immunol. 2000)
MHC I function by Shastri et al. (Annu Rev Immunol)
MIF by Bell (Nat Rev Immunol 2002)
Macrophage activation by Gordon (Nat Rev Immunol 2003)
Mucosal T cells by Cheroutre (Annu Rev Immunol 2004)
NKs & DCs by Moretta (Nat Rev Immunol 2002)
Pattern recognition receptors (except Nods) bty Gordon (Cell 2002)
Positive and negative selection by Starr et al. (Annu Rev Immunol 2003)
T cell development by Spits (Nat Rev Immunol 2002), Germain (Nat Rev Immunol 2002)
T cell activation by von Boehmer & Fehling (Annu Rev Immunol 1997), Alberola-Ila et al. (Annu Rev Immunol 1997), Davis et al., (Annu Rev Immunol 1998), by Garcia et al., (Annu Rev Immunol 1999), Lanzavecchia & Sallusto (Nat Rev Immunol 2002)
TLRs by Takeda et al. (Annu Rev Immunol 2003) Kaisho & Akira (Biochim Biophys Acta 2002), Medzhitov (Nat Rev Immunol 2001)
Semaphorins by Kikutani & Kumanogoh (Nat Rev Immunol 2003)
Superantigen by Li et al. (Annu Rev Immunol 1999)
V(D)J recombination by Gellert (Annu Rev Biochem 2002)

Other On-line papers
C.elegans and pathogens
Toll-related receptors and the control of antimicrobial peptide expression in Drosophila (Tauszig et al. PNAS 2000)
Genome-wide analysis of the Drosophila immune response by using oligonucleotide microarrays (Gregorio et al. 2001)
Internalin B (InlB) activates NF-B via Ras, PI-3 kinase and Akt (Mansell et al. J. Biol. Chem.)
In CSF-1 mutation (Op, 5 % macrophages), clearance, bacterial translocation and endotoxin shock, T-cell response.

Links

Link table in Nature Immunology
C. elegans extracellular matrix proteins
BD CD poster

(Recognition of pathogens during mammalian and plant host responses. TLR and Nod proteins mediate host recognition of pathogen components in animals. The products from plant pathogen resistant genes also mediate pathogen-specific responses. Inohara et al. 2001; Inohara et al., 2002; Inohara & Nunez 2003)

Copyright by Naohiro Inohara, Department of Pathology, University of of Michigan Medical School

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All-in-One Seq Analyzer

Group	Protein	apoptosis	Species	locus	KO	3D	binding partner	structure	TFs	upstream regulators	memo
CAM	ALCAM, MEMD, CD166		human, mouse, rat, dog, chicken	3q13.1-q13.2			CD6	IGx5/TM		RANTES, LPS, IL3, M-CSF, GM-CSF, Blimp1
	CD22, LEU14, BL-CAM, SIGLEC2	promote	human, mouse	19q13.1	L		sialylated staffs, CD45, AP50, SHIP1/Grb2/Shc	IGx7/TM		IL1b, Fas, BCR, Lyn, LPS, GR, IKKg	B vs B
	MAG, SIGLEC4A		human, mouse	19q13.1			sialosides	IGx4/TM		DEX, cAMP	brain
	LU, BCAM		human	19q13.2				IGx5/TM
	nephrin, Nphs1		human	19q13.1	1			IGx8/FN3/TM
	CD33, SIGLEC3	induce	human	19q13.3-q13.4	1		sialosides			SDF1, Lm	APCs
	SIGLEC5, CD33L2, OBBP2		human	19q13.3			sialosides	IGx3/TM			bm
	Nr-CAM, Bravo, NRCAM		human, mouse, rat, chicken	7q31.1-q31.2			contactin/F11, neurofascin, RPTPb, axonin-1	IGx6/FN3x3/TM	LEF-1	IL1a, b-catenin, Wnt	brain
	DDM36, NOPE		human	15q22.2
	neogenin, NEO1		human	15q22.3-q23				IGx6/FN3x6/TM	Pax6
	PUNC		human	15q22.3-q23	1			IGx4/FN3x2/TM
	MYBPC3		human	11p11.2				IGx6/FN3x2/IG/FN3/IG			heart
	MYBPC2, fast		human	19q13.33				IGx5/FN3x2/IG/FN3/IG			heart, tongue
	MYBPC1, slow		human	12q23.3				IGx5/FN3x2/IG/FN3/IG			skeletal muscle, tongue
	contactin 1, CNTN1		human, mouse, rat, bovine, chicken,zebrafish	12q11-q12	1		tenascin, Fyn, RPTPbeta, Caspr, NF155, Na+ channel	IGx6/FN3x4		St PhoP	brain
	contactin 2, CNTN2, TAX1, TAG1, axonin 1		human, rat, chicken, zebrafish	1q32.1	1			IGx6/FN3x4			brain
	neurofascin, NFASC		human, rat,	1q32.1			contactin, Na+ channel, Nr-CAM, syntenin-1, ankyrin	IGx6/FN3x3/TM
	IGSF9, Nrt1		human	1q22-q23				IGx4/FN3x2/TM
	L1CAM, MIC5, MASA, SPG1, HSAS1, N-CAML1 CAML1, CD171		human, mouse, rat,	Xq28	1			IGx6/FN3x4/TM	Pax6		brain
	contactin 5, NB2, CNTN5		human, rat	11q21-q22.2
	contactin 3, CNTN3, NIG1, PANG		human, mouse, rat	3p26
	contactin 4, BIG2, CNTN4, Axcam		human, mouse, rat,	3p26-p25				IGx6/FN3x4
	contactin 6, NB3, CNTN6		human, mouse, rat	3p26-p25				IGx6/FN3
	CALL, L1CAM2, CHL1	mediate?	human	3p26.1				IGx6/FN3x4/TM			brain
	ROBO1, roundabout 1		human	3p12				IGx5/FN3x2	TNFa
	ROBO4		human	11q24.2				IGx2/FN3x2
	BOC		human	3q13.2				IGx4/FN3x3/TM
	JAM3		human, mouse	11q25
	JAM2, VEJAM		human, mouse	21q21.2
	DSCAM, CHD2-42, CHD2-52		human	21q22.2				IGx9/FN3x2/IG/FN2/TM
	NCAM2		human	21q21.1				IGx5/FN3x2/TM		EV71
	NCAM1, CD56		human, mouse, rat, bovine, chicken, Xl, zebrafish	11q23.1	L	1	prion	IGx5/FN3x2/TM	NF-kB, Phox2, HOXC6, Hoxc8, Alx4, LEF-1, PLZF, OTX2, Cux-2?, Barx1, p73	TGFb, BMP2, AMPA-R, D2R	NK
	CDON, CDO, ORCAM		human	11q23-q24				IGx5/FN3x3/TM
	DSCAML1, KIAA1132		human	11q23				IGx9/FN3x4/IG/FNx2/TM
	SDK2, sidekick 2		human	17q25.2				IGx3/FN3x5/TM
	DCC, CRC18, CRCR1	induce	human	18q21.3	1			IGx4/FNx6/TM
	VCAM1, CD106	inhibit	human, mouse, rat, pig	1p32-p31	1	L	integrins, CD29	IGx6/TM	NF-kB, Egr1, AP-1, IRF1, IRF2, GATAs, Sp1,PPARa,	IL1, TNFa, LTa,dsRNA, IFNs,AngII, IL4, IL5, IL18, PKR, LDL, thrombin, C5a, Resistin, NO, RA, estrogens, glucocorticoids, UTP, LPS, BLP, Ct, Hp, Mt, Pc, ApoE, tax, osmolarity, P2Y2, p38, BMP2, IL10, ALA
	ICAM1, CD54	inhibit/(-)/mediate	human, mouse, rat, pig, sheep, bovine	19p13.3-p13.2	L	L	LFA-1, rhinoviruses, CD11, CD43, MIR	IGx5/TM	NF-kB, p53, c-Myc, EGR1, DLX-7, HOXD10, PDX1	IL1, IL5, IL6, IL18, TNFa, LTa, TRAIL, Fas, IFNa, PMA, CD3/28, BCR, C4BP, histamine, C5a, ML-1, LPS, BLP, LTA, MDP, OX-CA, LeIF, hsp65, Bm, Cp, Ct, Ld, Lm, Ma, Mt, Pc, St, Tg, CMV(IE2, pp70), MV, HHV8, oxidative stress, irrrad, hypoxia, IFNg, RA, glucocorticoid, p38, PKCd, Src, Nef, IL1b/TNFa, heat shock, PGE2., IL10
	ICAM3, CD50	mediate	human, bovine	19p13.3-p13.2			LFA-1, CD11, CD209	IGx4/TM		IFNa	B, T, APCs
	ICAM4		human	19p13.2-cen			LFA-1	IGx2/TM
	ICAM5, TLCN, TLN		human, mouse	19p13.2				IGx7/TM
	PECAM1, CD31	inhibit	human, mouse, bovine, pig,	17q23	L		CD38, Fyn, Lyn, Src, Yes, Hck, SHP1, SHP2, alphavbeta3 integrin,	IGx5/TM/ITIM	NF-kB, Egr1	TNFa, Fas, IFNa, IFNg, PMA, camptothecin	APCs
	ICAM2, CD102	inhibit	human, mouse	17q23-q25	1	1	LFA1, CD11b/CD18, CD209	IGx2/TM	GATA2,	TNFa, IL1, VEGF, Cp, Yp, ALK1
	TCAM1		mouse, rat								testis
	CMRF35		human	17q22-q24				IG/TM		Fas, camptothecin	monocyte
	CMRF35H9, IRC1		human	17q22-q24				IG/TM			NK, APCs
	TREM4, LOC146894		human	17q21.31				IG/TM
	NKIR		human	17q25.2				IG/TM
	TACTILE		human	3q13.2				IGx3/TM			T, NK
	LAMP, LSAMP		human	3q13.2-q21				IGx3/TM
	IGSF10, CMF608, FLJ25972		human	3q25.1				IGx7
	MAdCAM1		human, mouse, rat	19p13.3		L	CD29	IG	NKX2.3	Hp, b-catenin
	CEA, CEACAM5, CD66e	inhibit	human	19q13.2				IG x7	c-Myc, PPARg	LPS,cisplatin
	CD66a, BGP, CEACAM1	(-)/induce	human	19q13.2		1	Src, SHP1, SHP2, galectin-3	IGx3/TM/ITIM	Hoxd10	RA, VEGF
	CGM1, CD66d, CEACAM3	induce	human	19q13.2				IG/TM
	CEAL, NCA, CD66c, CEACAM6	inhibit	human	19q13.2				IG x7		estrogen, As2O3	lung, bm
	CEACAM7, CGM2		human	19q13.2				IGx2		RA
	CD66b, CD67, CGM6, NLA95, CEACAM8		human	19q13.2			galectin-3	IGx3		hemin, PACAP
	PSG3		human	19q13.2				IGx4			placenta
	PSG8		human	19q13.2							placenta
	PSG10		human	19q13.2							placenta
	PSG1		human	19q13.2							placenta
	PSG6		human	19q13.2							placenta
	PSG7		human	19q13.2							placenta
	PSG11		human	19q13.2							placenta
	PSG2		human	19q13.2							placenta
	PSG5		human	19q13.2					Sp1		placenta
	PSG4		human	19q13.2							placenta
	PSG9		human	19q13.2							placenta
	TSLL2		human	19q13.32				IGx3/TM/4.1m
	SIGLEC7		human	19q13.3		1	sialic acid, disialogangliosides, sialosides	IGx3/TM		Fas, camptothecin	NK, APCs
	SIGLEC8, SAF2		human	19q13.33-q13.41			sialosides	IGx3/TM
	SIGLEC9		human	19q13.41			sialosides
	SIGLEC10		human	19q13.3				IGx4/TM			B, NK
	SIGLEC11		human	19q13.33				IGx4/TM			adrenal gland
	SIGLECL1		human	19q13.4				IGx4/TM
	OSCAR		human	19q13.42				IGx2/TM	PU.1
	PVR, PVS, CD155	mediate	human	19q13.2-q13.3	mt		PV, vitronectin, Tctex-1		NRF1, GLI1, GLI3	Shh, CMV
	basigin, BSG, TCSF, EMMPRIN, CD147		human, mouse, rat, chicken, zebrafish	19p13.3	L		basigin, MCT1, MCT4	IGx2/TM	Stat4b	TSH	bm
	SDFR1, gp65, gp55		human	15q22				IGx2/TM			brain
	embigin, gp70IC		human, mouse, rat	5q11.2				IGx2/TM			bm
	MGC71745		human	5q11.2				IGx2/TM			NK, B, T, APCs
	sialoadhesin, SN, CD169, SIGLEC1		human	20p13		L	sialic acid, sialosides	IGx17/TM		IL-4, IFNb, IFNg, LPS	bm
	NEPH1, KIRREL		human	1q21-q25				IGx4/TM
	NEPH2, Kirre, SST4		human	11q24				IGx5/TM
	MCAM, MUC18, CD146		human	11q23.3				IGx5/TM	AP2	TNFa, IL1, hCG, PMA, cAMP
	SYNCAM, TSLC1, BL2, ST17, IGSF4		human	11q23.2				IGx3/TM/4.1m
	HVEC, PVRR1, PRR, nectin 1, PVRL1		human	11q23-q24	1		afadin, HSV	IGx3/TM		Ma, Fas, camptothecin
	nectin 2, Pvrl2, CD112, HVEB, PVR, PVS		human, mouse	19q13.2-q13.4	1			IGx3/TM
	PVRL3, PPR3, PRR3, PVRR3, nectin-3,		human	3q13			afadin			placenta
	CD47, IAP	mediate	human, mouse, rat, bovine, viruses	3q13.1-q13.2	L		SIRPs, alpha v beta 3 vitronectin, Rh, SHPS1	IG/TMx5		Yp, MVA, EV71, TNF, IL1, GM-CSF, NIP3, SDF1
	CD200R, OX2R, MOX2R		human	3q13.2			CD200	IGx2/TM
	CD200, OX2, MOX2		human	3q12-q13	1		CD200R	IGx2/TM
CAM(IG)	SNS, CG33141		Dm, Ag					IGx9/FN3/TM
	CG8964		Dm

group	name	apoptosis	species	locus	KO	3D	binding partner	structure	TFs	upstream regulators	memo
protocadherin	alpha 1, PCDHA1		human	5q31							brain
	PCDHA2		human	5q31							brain
	PCDHA3		human	5q31							brain
	PCDHA4		human	5q31							brain
	PCDHA5		human	5q31							brain
	PCDHA6		human	5q31							brain
	PCDHA7		human	5q31							brain
	PCDHA8		human	5q31							brain
	PCDHA9		human	5q31						IL1	brain
	PCDHA10		human	5q31							brain
	PCDHA11		human	5q31							brain
	PCDHA12		human	5q31							brain
	PCDHA13		human	5q31						TNFa	brain
	PCDHB1		human	5q31
	PCDHB2		human	5q31
	PCDHB3		human, mouse	5q31
	PCDHB4		human, mouse	5q31
	PCDHB5		human, mouse	5q31
	PCDHB6		human, mouse	5q31
	PCDHB7		human, mouse	5q31
	PCDHB8		human	5q31
	PCDHB9		human	5q31
	PCDHB10		human	5q31
	PCDHB11		human	5q31
	PCDHB12		human	5q31
	PCDHB13		human, mouse	5q31
	PCDHB14		human, mouse	5q31
	PCDHB15		human, mouse	5q31
	PCDHB16		human, mouse	5q31
	Pcdhb22		mouse
	protocadherin gamma A1, PCDHGA1		human, mouse	5q31							brain
	PCDHGA3		human, mouse	5q31							brain
	PCDHGA4		human	5q31							brain
	PCDHGA5		human	5q31							brain
	PCDHGA6		human	5q31							brain
	PCDHGA7		human	5q31							brain
	PCDHGA8		human, mouse	5q31							brain
	PCDHGA9		human, mouse	5q31							brain
	PCDHGA10		human	5q31							brain
	PCDHGA11		human	5q31							brain
	PCDHGA12		human	5q31							brain
	protocadherin gamma B1, PCDHGB1		human, mouse	5q31							brain
	PCDHGB2		human, mouse	5q31							brain
	PCDHGB3		human	5q31							brain
	PCDHGB4		human	5q31				Cadx5/TM			brain
	PCDHGB5		human	5q31							brain
	PCDHGB6		human	5q31							brain
	PCDHGB7		human, mouse	5q31							brain
	Pcdhgb8		mouse	5q31
	protocadherin gamma C3, PCDHGC3		human	5q31							brain
	PCDHGC4		human, mouse	5q31							brain
	PCDHGC5		human	5q31							brain
	PCDH12		human	5q31							brain
	PCDH1		human	5q32-q33
	PCDH19		human	Xq13.3							brain
	PCDH11X		human	Xq21.3
	PCDH11Y, protocadherin-PC	affect?	human	Yp11.2
	protocadherin 15, PCHD15		human, mouse	10q21-q22	US			Cadx11/TM
	protocadherin 16, PCDH16		human	11p15.4
	PCDH8, PAPC		human	13q14.3-q21.1						Mesp2	brain, epithelium boundary
	PCDH9		human	13q14.3-q21.1							brain
	PCDH17		human	13q14.3						IL1	brain
	PCDH20		human	13q21							brain
	CDH24, FLJ25193		human	14q11.2				Cadx4
	also see flamingo subfamily of 7TM

group	proposed	name	ligand/receptor	apoptosis	species	gene	locus	KO	3D	gene regulators	memo
CC	SCYA1	I309, CCL1	CCR8		human, mouse		17p13.2		1	TCR, IL12, IFNa, IL31
	CCL2	MCP1, MCAF, SCYA2	CCR2	inhibit	human, mouse, rat, bovine, rabbit,pig,dog,	1	17q11.2-q21.1	L	1	NF-kB, Sp1, C/EBPs, AP1, EGR1, Bcl6, PDX1, Hoxc8, NRF2, EWS/FLI-1, TNFa, LTa, TRAIL, Fas, RANKL, IL1, IL4, IL13, IL17, IFNa, IFNg, GM-CSF, IL1b/IFNg,IFNk, PDGF-BB, RA, PMA, AgII, C5a, EP4, VIP, PACAP, insulin, Resistin, estrogens, Wnt1, Akt/PKB, IKKs, p38, PLC, LPS, BLP, LTA, PGN, KF1B, MDP, OX-CA, Bm, Ec, St, Sa, Lm, Mt, Pg, Tc, TBhsp70, BCGhsp65, flagellin, BCG, Cp,Hp, Pa, Tg, dsRNA, HCV, RSV, AdV, HHV8, UVB, shear stress, RANTES, SCF, VEGF, plasmin, p38, Cannabinoid, doxorubicin, Alprazolam, Bmp6, Bmp7, estrogen, PGE2, Gab2, EP4, BMP2, IL10, AgII, IKKs, SOCS1
	CCL3	MIP1a, LD78, SCYA3	CCR1, 5	inhibit/promote	human, mosue, rat, chicken		17q11-q21	L	1	NF-kB, C/EBPs, Ets2, p53, PPARg, IL3, IL2, IL6, IL15, GM-CSF, Ets, serum, TNF, FasL, Fas, RANKL, CD40, IFNk, XNA,VIP, PACAP, LPS, PGN, MDP, TBhsp70, LTA, b-glucan, BCGhsp65, BCG, Ec, Ld, Lm, Ma, Mt, Sa, Sm, St, g-irrad, NO., PMA, FceRI, CD3/28, BCR, CD43,Nef, CD3&IL2, Bcl6, RANTES, RA, D3, PGE2, Rac2, AmB, camptothecin, ribavirin
	CCL3L1	LD78-beta			human		17q11.2			PMA
	CCL4	MIP1b, ACT2, LAG1, SCYA4	CCR5	promote	human, mouse, rat, rabbit		17q21		L	CREB, LPS, CD40, TNF, RANKL, FasL, IL1, IL3, IL10, IL2, IL12, IL15, IL31, GM-CSF TCR/CD3/CD8/CD28, BCR, XNA, PMA, CD43, MIP3, Subst.P, CD3&IL2, MDP, flagellin, b-glucan, BLP, Bm,,Hi, Ld, Lm, Ma, Mt, Sa, Sp, g-irrad., HCV, Nef, dsRNA, CpG, OX-CA, Cannabinoid, CsA, estrogen, RANTES, SCF, D3, PGE2, AmB, ribavirin
	CCL4L1	LAG1, LAG-1, SCYA4L, AT744.2			human		17q12
	CCL5	RANTES, SCYA5	CCR1,3,5	inhibit/promote	human, mouse,rat, bovine	1	17q11.2-q12	1	L	NF-kB, IRF1, IRF3, IRF7, AP1, AIRE, RFLAT1, HSF1, IL1, IL2, IL17, TNF, CD40, CD8/28, LTa, RANKL, IFNs, IL12, TCR, M-CSF, GM-CSF, VIP, PACAP, LPS, PGN, MDP, LTA, Bm, Hp, Ld, Lm, Mt, Tg, Ct, Ma, Mt, Pg, Yp, dsRNA, EV71, VLP, CD28, BCR, IFNg, IL17, SCF, EP4, BRCA1, PMA, RSV, IKKs, IKKi, TBK1, TAK1, JNK, CFTR, DEX, estrogen, androgen, D3, EP4, IKKs	targets
	CCL6	c10, MRP-1, SCYA6			mouse					Hf ,Sm
	CCL7	MCP3, SCYA7	CCR1,2,3		human, mouse,rat		17q11.2-q12		L	NF-kB, Hoxc8, b1-integrin, b-catenin, TRAIL, IL1, IL17, TNFa, RANKL, VEGF, PMA, Bcl6, insulin, NO, BLP, Bm, Ld,, Lm, Mt, Pg, Sp, Tg, VLP, DEX, BMP2, IL10, IKKs, camptothecin, cantharidin, ALA, SOCS1
	CCL8	MCP2, SCYA8	CCR3		human,mouse, pig,bovine		17q11.2		1	IFNg, IL1, RANKL, LPS, PGN, Lm, Mt, Tg, VLP
	CCL9	MIP-1 gamma, SCYA9			mouse					NF-kB, NRF2, PPARg, AIRE, TNF, RANKL, IL1, LPS, D3
	CCL11	eotaxin 1, AI1, SCYA11	CCR3		human, mouse, rat, pig, house,bovine		17q21.1-q21.2	L	L	NF-kB, STAT6, IL13, TNFa, IL1b, IFNg, IL4, IL9, IL25, LPS, PGN, LTA, Lm, Mt, VLP, glucocorticoid, TGFb1, estrogen, HuR, A2aR
	CCL12	MCP5, eae7, TCA-3, SCYA12			mouse					LPS, CpG, Lm, IFNabR1, TRIF
	CCL13	MCP4, NCC1, SCYA13	CCR2,3		human		17q11.2			TNFa,TRAIL, IFNg, IL4, PGN, glucocorticoid, RA
	CCL14	NCC2, SCYA14	CCR1		human		17q11.2		1	IFNa, TNFa, c-Myc, IL1,ALK1, TGFR1
	CCL15	MIP1d, NCC3, leukotactin, MIP5, SCYA15	CCR1,3		human		17q11.2			ALA
	CCL16	NCC4, SCYA16	CCR1		human		17q11.2			SCF
	CCL17	TARC, SCYA17	CCR4		human, mouse		16q13			TNFa, IFNg, IL10, IL25, IL31, SCF,LPS, Lm, Mt, Tg, BMP2
	CCL18	PARC, AMAC1, DC-CK1, SCYA18			human		17q11.2			IL10, D3, TCR/CD3, LPS, Ca,Mt, Sa, influenza v, TNFa, CD40L,IFNg,
	CCL19	MIP3b, exodus-3, CCL19, ELC, SCYA19	CCR7		human, mouse		9p13			IL31, Ma, LPS
	CCL20	MIP3a, exodus-1, CCL20, Larc, SCYA20	CCR8		human, mouse, rat		2q33-q37			NF-kB, Sp1, ESE1, EWS/FLI-1, IL1, TNFa, LTb, PMA, LPS, PGN, Bm, Ld, Lm, Mt, Tg, Ye, flagellin, UVB, hypoxia, D3, MEK1, camptothecin, ALA
	CCL21	SLC, exodus-2, SCYA21	CCR7	inhibit	human, mouse(a,b,c)		9p13			SCF, Prox1, PMA
	CCL22	MDC, STCP-1, SCYA22	CCR4		human, mouse		16q13			IL1b, SCF, IL12, IL13, IL31
	CCL23	MPIF1, Ckb-8, SCYA23	CCR1		human		17p13.2		1	IL31, Mt, LPS
	CCL24	eotaxin 2, MPIF2, SCYA24	CCR3		human, mouse		7q11.23		L	LPS, IL-4
	CCL25	Teck, SCYA25	CCR9	inhibit	human, mouse		19p13.2			VDR, Egr1, AIRE
	CCL26	eotaxin 3, SCYA26	CCR3		human		7q11.2			STAT6,IL4, IL13, TGFb
	CCL27	CTACK, ILC, ALP, Eskine	CCR10		human, mouse		9p13			TNFa, NRF2, PMA
	CCL28	CCL28	CCR3, CCR10		human, mouse		5
CXC	CXCL1	Groa, Gro1, MGSA, SCYB1, KC	CXCR2		human, mouse		4q12-q13		1	NF-kB, NF-IL6, Sp1, HMG-I, C/EBP, PPARg, EWS/FLI-1, TRAIL, TNFa, IL1, IL17, IL31, XNA, VEGF, insulin, LPS, PGN, KF1B, MDP, BLP, LTA, Ec, Ld, Lm, LLO, Mt, Pg, St, Sa, Tg, Ye, hsp70, hsp65, flagellin, BCG, AdV, UVB, HHV8, VLP, BMP2, IL10, Wnt3a,
	CXCL2	MIP2, MIP2a, Grob, Gro2, SCYB2	CXCR2		human, mouse		4q12-q13		1	NF-kB, c-Myc, PPARg, EWS/FLI-1, IL1, IL17, TNFa, FasL, RANKL, XNA, PMA, C5a, GM-CSF, LPS, BLP, PGN, KF1B, MDP, LTA, R848, Bm, Cd, Ct, Ec, Hp, Ma, Mt, Ld, Lm, Pg, Sa, Sd, St, Tg, Ye, flagellin, HCV, RSV, dsRNA, VLP, FVIIa, DEX, NO, hypoxia, Subst.P, VIP, PACAP, UVB, estrogen
	CXCL3	MIP2b, Grog, SCYB3	CXCR2		human		4q21			IL1, TNFa, LPS, PGN, MDP, LTA, Bm, Hp, Ld, Lm, Mt, St, Tg, Ye, flagellin, HHV8, UVB, DEX, D3
	CXCL4	PF4, SCYB4		inhibit	human, mouse		4q12-q13			Ets1, GATA1, PDX1, IL6
	PF4V1	PF4A, CXCL4V1, PF4-ALT, SCYB4V1			human		4q12-q21
	CXCL5	ENA78, SCYB5, LIX	CXCR2		human, mouse		4q12-q13			AIRE, GCSF, IL1, IL17, TNF, BMP2, LPS, hsp65, Hp, Hf, Mt, Pg, VLP	induces NF-kB
	CXCL6	GCP2, SCYB6	CXCR1,2		human		4q12-q13			EWS/FLI-1, IL1, TNFa, BAFF, IFNg, PGN, DEX
	CXCL7	proPBP, CXCL7, (CTAP3, TGb, NAP2, TC1, TC2), SCYB7, PPBP	CXCR2		human, mouse		4q12-q13			PU.1, IL1b/TNFa, Pg
	CXCL8	IL8, see ILs	CXCR1, 2							PGN, IL1
	CXCL9	MIG, SCYB9	CXCR3		human, mouse		4q21			STAT1, NF-kB, CBP, IFNg, B-DNA, PPARg, TNF, EP4, IL12, IL10, Hf, Hp, Lm, Mt, Pg, Tc, Tg
	CXCL10, SCYB10	IP10, INP10, Mob1	CXCR3	(-)	human, mouse		4q21	L		NF-kB, Hoxc8, IL1, TNF, LTa, Fas, IFNa, IFNb, IFNg, IL4, VEGF, Subst.P, EP4, cholecystokinin, CpG, LPS, BLP, Ec, Pg, St, Sa, Lm, Mt, Tg, TBhsp70, BCGhsp65, BCG, dsRNA, HCV, MV, AdV, HHV8, VLP, PGE2, estrogen, STAT1, PPARg1, IFNabR1, TRIF, MyD88
	CXCL11	IP9, ITAC, CXCL11, SCYB11	CXCR3		human		4q21.2			TNFa, IFNa/b, IFNg, PPARg, LPS, B-DNA, Mt, Tg, TRIF
	CXCL12	SDF1, pre-B, CXCL12, SCYB12	CXCR4	induce/inhibit	human		10q11.1	L	L	NF-kB, TNFa, CD8/28, Wnt1, Hf, Hi, VLP, IL3, ER, PTEN, IKKs, estrogen	targets
	CXCL13	BLC, BCA1, CXCL13, SCYB13	CXCR5		human		4q21	L		A2aR, LPS, Hp, IL10
	CXCL14	BRAK, SCYB14			human, mouse		5q31			AIRE, HCV, estrogen
	CXCL15	Lungkine			mouse			1
	CXCL16	SRPSOX	CXCR6		human, mouse		17p13			PGN, IFNg, TNFa, Pg	induce NFkB
	XCL1, SCYC1	XCL1, SCM1, SCM1a, lymphotactin	XCR1	promote	human, mouse		1q21-q25			CsA/FK506, CD3&IL2, PMA, VLP, Pg, androgen
	XCL2, SCYC2	XCL2, SCM1b	XCR1		human		1q23
CX3CL	CX3CL1, SCYD1	Fractalkine, Neurotactin (NTN)	CX3CR1		human, mouse, rat		16q13			NF-kB, NRF2, PDX1, IL1, IFNg, TNFa, SCF, FSH, St, flagellin, EP4, IKKs, androgen
CCR (7TM)	CCR1	CKR1, HM145, CMKBR1	CCL3, 5, 7, 14, 15 ,16 ,23		human, mouse		3p21	L		NF-kB, ARNT2, TNFa, RANKL, IFNa/b, IFNg, IL-2, IL5, IL6, IL8, PMA, IL15, LPS, b-glucan, Lm, CD3/28, RANTES, IL10, D3, ErbB4	APCs
(G-coupled)	CCR2	CKR2, CMKBR2	CCL2(MCP1), 12,13,	(inhibit)	human, mouse		3p21	L		IL2, IL15, IFNa, RANKL, Lm, Tc, NF-kB, PMA,GCSF, SCF, estrogen, D3	APCs
	CCR3	CKR3, CMKBR3	CCL5(RANTES), 6, 8, 11, 13, 15, 24, 26		human, mouse		3p21.3	1		IFNg, IL2, IL3, IL4, IL25, estrogen	eosinophil
	CCR4	CKR4, CMKBR4	CCL17, 22(Tarc, MDC)		human, mouse		3p24	L		BCR, IL18, G-CSF
	CCR5	CCCKR5, CKR5, CD195	CCL3, 4, 5 (MCP2, MIP1a, MIP1b)	mediate	human,mouse		3p21	L		NRF2, TNFa, IL6, IL12, TCR, PMA, BCR, Lyn, IFNg, M-CSF, Tc, EV71, IL10, D3, Rac2, rapamycin	APCs/T, HIV-1 coreceptor
	CCR6	CKRL3/GPR29/GPRCY4/STRL22/CMKBR6	CCL20(MIP3a,)		human, mouse		6q27	1		AIRE, IL10, IL4, IFNg, LPS, MDP, hypoxia/CD3	B, Sd
	CCR7	EBI1, CMKBR7, CD197	CCL21	inhibit	human, mouse		17q12-q21.2	L		NF-kB, IL18, Notch, LPS, Bm, Ld, Lm, Mt, Tg, VLP, PMA, DAP12, TREM2, estrogen, D3	B/T
	CCR8	CKRL1/CMKBR8/CMKBRL2	CCL22 (Tarc, MIP1b)		human, mouse		3p22	L
	CCR9	GPR-9-6, CCBP2	CCL25	inhibit	human, mouse		3p21.3	L		TNFa	TECK
	CCRL1	CCRL1, PPR1			human, mouse		3q22
	CCRL2	CCRL2, HCR, CKRX, CRAM-A			human, mouse		3p21			G-CSF, D3	CD71+
CXCR (7TM)	CXCR1	IL8R1, IL8Ra	CXCL6, 8		human		2q35			NF-AT, NF-kB, PU.1, IL2, IL15, Subst.P, D3, IFNa	neutrophil
	CXCR2	IL8R2, IL8Rb	CXCL1,2,3,5,6,7,8		human, mouse		2q35	L		Fas, camptothecin	neutrophil
	CXCR3	GPR9, CD183	CXCL9, 10, 11,		human, mouse		8p12-p11.2	L		SCF, ribavirin, TCR	mDC
	CXCR4	Fusin,NPY3R, D2S201E, LESTR, HM89, LAP3, CD184	CXCL12 (SDF1)	inhibit	human, mouse		2q21	L		NF-kB, USFs, c-Myc, YY1, CD40, , TCR/CD3, Tprim, BCR, PMA, LPS, Bm, Ld, Lm, Mt, Tg, Ma, IL2, IL4, IL7, IL13, IL15, VEGF, ALK1, BMP2, L-selectin, cAMP	B/T/NK/mDC
	CXCR5	BLR1	CXCL13		human, mouse		11	L		SCF, TNFa, IFNg	B, HIV coreceptor
	CXCR6	Bonzo, STRL33	CXCL16		human, mouse		3p21	1		HCV
CX3CR	CX3CR1	V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1	CX3CL1		human, mouse		3p21			TNFa	NK
XCR	XCR1	GPR5/lymphotaxin receptor	XCL1, 2		human, mouse		3p21.3

response		name	species	locus	KO	apoptosis	domain structure	3D	binding partners	gene regulators	memo
viral	TPR	IFI56, IFIT1, G10P1, RNM561, GARG-39	human	10q23.3			TPRs			IFNa, IFNb, IFNg(-), BRCA1,IRF3, PLZF, BLP, HCV, TNFa, TRAIL, Fas, FSH, LPS, LTA, B-DNA, Bm, Hp, Ld, Lm, Mt, Tg, dsRNA, VLP, (p38), ER, ribavirin, SOCS1
		IFI54, IFIT2, G10P2, GARG-16	human	10q23.3			TPRs			AIRE, IFNa, EP4, LPS, LTA, B-DNA, Ct, Bm, Ld, Lm,Mt, Tg, VLP, IRF3, (p38), SOCS1
		IFIT3, IRG2, IFI60, IFIT4, ISG60, RIG-G, CIG-49, GARG-49	human	10q24			TPRs			Hp, VLP, B-DNA, SOCS1
		RIG-G, IFI60, IFIT4	human	10q24			TPRs			LPS, Lm, Mt, Tc, Tg, IFNa, IFNb, TNFa, IRF3, (p38), glucose, HCV
		IFIT5, RI58	human	10q23.3						IFNa, LPS
	OIAS	2',5'-oligoadenylate synthetase, OIAS, OAS1	human, mouse	12q24.2		induce	OAS	1		PLZF, TNFa, IFNa, IFNb, IFNg(-), LPS, Sm, HCV, tributyltin	2-5As actiavates RNase L
		OAS2	human	12q24.2						IFNa/b, TNFa, LPS, Mt, Tg, HHV8, IL12, TGFb, SOCS1
		OAS3, p100	human	12q24.2						IFN, TNFa
		TRIP14, OASL	human	12q24.2			OAS/Ub x2			IFNa, TNFa, Bm,Ld, Lm, Mt, Tg, DV
	Exonuc.	ISG20, HEM45	human	15q26			Exonuclease			IFNa, IFNb, IL13, LPS, LTA, Bm, Ld, Lm, Mt, Tg, estrogen, TRIF, SOCS1
	ABC	RING4, TAP1	human	6p21.3	L		ABC transporter			CIITA, IFNa, b, g, dsDNA,HCV, dsRNA, Hp, Hf, UVB
	TM	IFI17, IFI9-27, IFITM1	human, bovine	11p15.5			TMs			IFNa, b ,g, BRCA1, TNFa, TRAIL, LPS, Ct, Bm,Lm, Mt, Tg, Bcl6, DAC/TSA, PMA, IL15, EBV, ribavirin,	anti-viral
		IFITM2, IFI1-8D	human	11p15.5			TMs			IFNs, Ets1
		IFITM3, IFI1-8U	human, mouse(fragilis), rat, bovine,	11p15.5						IFNa, LPS, Lm, Mt, Tg, TRIF
	FAM14	IFI6-16	human	1p35			singal/TM			IFNa, IFNb, IFNg(-), HCV, TNFa,TRAIL, Fas, N-Myc,ribavirin, Ets1
		IFI27, ISG12	human	14q32						EWS/FLI-1, IFNa/b, VEGF, MVA
		FAM14A	human	14q32.2
		FAM14B	human	14q32.2
	INDO	INDO, indole 2,3-dioxygenase	human	8p12-p11		enhance /inhibit				IL1, IL12, IL18, TNFa, IFNa,b, IFNg, LPS, MDP, ssRNA, Bm, Ld,Mt, Tg, VLP; NO	Trp to L-kynurenine
	Mx	MxA, IFI78, MX1	human, mouse, rat, pig, sheep, bovine, dog, chicken, duck, trout, zebrafish, fugu	21q22.3		enhance	Dynamin/GED	m		IFNa, IFNb, IFNk, IFNg(-), IL2, BRCA1, LPS, LTA, Mt, Lm, dsRNA, B-DNA, HCV, DV, HHV8, (p38), ribavirin, TRIF
	Mx	MxB	human, mouse, bovine, salmon	21q22.3			Dynamin/GED			IFNa, IFNb, IFNg(-), HCV, TRAIL, LPS, LTA, hsp65, Ld, Lm, Mt, Tg, TRIF
	IFI20x	IFI16, p202, p204 (mouse)	human	1q22	SLE	enhance /inhibit	Pyrin/HINx2		Rb, BRCA1, 53BP1, CBFA1, NF-kB, p202	IFNa,b,g, HCV, TRAIL, Fas, IL5, IL6, IL12, LPS, B-DNA, hsp65, Tc, VLP, BMPs, HOXD3, DEX, p53, BMP2, TRIF, SOCS1	systemic lupus
		MNDA	human	1q22			Pyrin/HINx2
		AIM2	human	1q22		enhance	Pyrin/HINx2			IFNa/b
	secret	IFI30, IP-30, GILT	human	19p13.1			signal			IFNa,b,g, TNFa, EBV, AmB, Wnt3a
	PPM	IFI35, IFP35	human	17q21			PPM			PLZF, IFNa,b,g, FSH, LPS, IL15, DEX
		SP110, IFI41, IFI75	human	2q37.1			SAND			IFNa, b, IFNg
	GBP	GBP1	human				GBP			IFNa, TNFa, dsRNA, B-DNA, LPS,MDP
		GBP2	human	1pter-p13.2			GBP			IFNa,b,IFNg, SOCS1
	TLCd	IFI44, p44, MTAP44	human	1p31.1			TLCd			IFNa, b, IRF3, LPS, B-DNA, HCV
		C1orf29, GS3686	human	1p31.1						IFNa/b, CIITA
	TTF	TTF2	human	1p22			DEXD/helicase			IFNa	transcriptional termination
	crystallin	AIM1	human	6q21			crystallinx6/ricin			ALK1, MITF, PLZF, E2F, GR, FSH, HHV8
	Elp3	CIG5	human	2p25.2			Elp3			IFNa, IFNb
	HD	SAMHD1, DCIP	human	20pter-q12			SAM/HD			IFNa/b, IFNg
		hORC2L	human	2q33						Pa,
		Tristetraproline(TTP)/ZFP36	human	19q13.1	1		EZF			Pa, St, mitogens, Sp1, CD3/28,FVIIa	destabilize TNFa mRNA
		BRF1, ERF1, cMG1, ERF-1, Berg36, TIS11B, RNF162B, ZFP36L1	human	14q22-q24	1	inhibit?	Tis11b_C/CCCHx2			IL-4, Ca2+
		PBEF	human, mouse, rat,	7q22.1-7q31.33						TNFa, PMA, BAFF, LPS, Bm, Ld, Lm, Mt, Tg, MDP, NO,
	NOS	iNOS/NOS2/NOS2A	human, mouse, rat, guinea pig, dog, horse, carp	17q11.2-q12	L	enhance/inhibit		L		NF-kB, NRF, IRF1, C/EBPbeta, ATF2,Oct-1, Brn-3, RXR, PPARg, Elk3, STAT1, KLF6, p300, IL1b, IL13, IL15, IFNg, IFNb, somatostatin, Subst.P, LPS, MDP, sBLP, flagellin, St, Sd,HBx, O stress, shear stress, heat shock, hypoxia, PMA, progesterone, estradiol, DEX, D3, melatonin, NO,IL-4, Galpha13,PKCe, RON, Jak2, PI3K, p38, TGFb, IL10
		NOS II/NOS2B	human	17p13.1-q25
		eNOS/NOS3	human, mouse, guinea pig, bovine, pig,	7q36	L					Sp1, GATA-2, IL10, TNFa, PI3Kg, Jak2, MEK1, ERK1,2
		nNOS, NOS1	human, mouse, rat, rabbit, dog, fugu, zebrafish	12q24.2-q24.31	L			1		CREB, Oct-2, AgII
	ROS	SOD2	human							TNFa

	HB-EGF	HB-EGF/diphtheria toxin receptor(DTR)/DTS	human,mouse, rat	5q23	L	inhibit/induce	signal/EGF-TM	1		AP1, v-Jun, p53,RARalpha, Cp, Hp, TNFa, IL1, PMA,GM-CSF, VEGF, gastrin, PAF, AGII, Thrombin, H2O2, stretch, shear stress, UVB, lysophospholipid, estradiol, progesterone, B-Raf, Raf-1, Ras,	mitogen binding to EGFR, inhibit NF-kB
	HGF	HGF, hepatopoietin A , scatter factor	human	7q21.1	L	inhibit/induce	PAN/kringlex4/trypsin		c-Met(HGFR)	LPS, MDP, Ma, St, IL1, TNFa, IFNg, AP2, C/EBPs, Sp1, Sp3, USF, Stat3, DEX, ER, TGFb1,c-Src,	liver
	D2S448	D2S448	human				LRRs/IGx4/perioxidase/VWC			Ct
	G0s2	G0s2	human	1q32.2-q41			secreted			LPS, MDP, LTA
	MIF	MIF	human, mouse	22q11.2	L	induce, inhibit	MIF	1		LPS, polyIgA, CD3/28/TCR, VLP, thrombin, FXa, hypoxia, glucocorticoid, insulin, hypoxia, glucose, UV-B, VitE, estrogen
	MIF	D-dopachrome tautomerase, DDT	human, mouse, rat	22q11.2			MIF
	MARCKS	MacMARCKS	human				MARCKS		Ca, CaM, PKCs	LPS,
	GCH1	GCH1, GTP cyclohydrolase 1	human	14q22.1-q22.2						LPS,MDP
	LITAF	PIG7, LITAF	human	16p13.3-p12			LITAF			A-Myb,B-Myb, p53, LPS, APC, cantharidin, calcineurin	activate NF-kB
	pentraxin	PTX3	human	3q25	1	(clearance)	PTX		bacteria	NF-kB, E2F, EWS/FLI-1, IL1b, TNFa, CD43, IFNg, LPS, MDP, LTA	anti-bacterial/fungal
		SAP, APCS	human	1q21-q23	1
		CRP	human	1q21-q23			PTX
		neuronal pentraxin I, NPTX1	human	17q25.1-q25.2			PTX		taipoxin	KCl
		neuronal pentraxin receptor, NPTXR	human	22q13.1			PTX
		neuronal pentraxin I, NPTX1	human	9q31-q32			Sushix3/HYRx2/Sushi/TNFR/EGFx6
	ADPrc	CD38	human	4p15	1					LPS, hsp65, TIMP1
	GTPase	IGTP	mouse							IFNa/b, IFNg, B-DNA, Lm, LTA, SOCS1
		GTPI	mouse							IFNa/b, IFNg, Lm, LTA, SOCS1
	cAMP/cGMP cleavage	GCH1, GCH, DYT5, GTPCH1	human	14q22.1-q22.2	hph1					LPS	cGMP
		PDE4B	human							LPS, Lm, IL10	cAMP
	CD87	CD87, UPAR, URKR	human	19q13						IFNa
	IFRD	IFRD1, PC4, TIS7	human, rat, chicken, frog, zebrafish, fugu, fly, Ce, At, Nc, An	7q22-q31			IFRD/IFRD-C			IFNa
		SM15, IFNRP, SKMc15	human, mouse, rat,	3p21.3			IFRD/IFRD-C
	LSP1	LSP1	human	11p15.5			caldesmon-C			IFNa
	LENG4	LENG4, BB1	human	19q13.4			TMx2/MBOAT /TM			IFNa
	CRISP	CRISP1	human	6p21.1-p21.2						LPS	thyroid
	FIZZ	FIZZ3, resistin (RETN)	human	19p13.2			RETN				neutrophils
	TGTP		human							B-DNA
TNF	SA	Serum amyloid A3	human							TNFa, IKKs
		PAI2, PLANH2, Serpin B2, SERPINB2	human	18q21.3			Serpin			TNFa,IKKs
		epiregulin	human	4q13.3						NF-kB, TNFa, IKKs
	DUF758	TNFAIP8, GG2-1, SCC-S2, MDC-3.13	human			inhibit	DUF758 (without DED)			TNFa, ALA
	SEC6	TNFAIP2, B94	human, mouse,	14q32			SEC6			NF-kB, TNFa, IL1, MDP, Ma, Bm, Ld, Lm, Mt, Tc, Tg
		XTP7	human	19q13.32			SEC6			HBx
		SEC6	human, mouse, rat,zebrafish, fly, Ce, Sc	5p15.33			SEC6
		LOC283849	human	16q22.1			SEC6
AngII		Osteopontin	human, mouse, rat, chick, bovine, rabbit,J.quail,	4q21-q25	L	inhibit	Osteopontin/TM		alphavbeta(3) integrin	Oct1, Oct4, Sox2, Ets1, Hoxa-9, c-Myc, USF, AP-1, Egr1, p53, CBFA, TGFb, PTHrP, PDGF, HGF,AgII, LIF, IL6, M-CSF, IL1, PMA, FGF1, D3, ER, estrogen, progesterone,glucocorticoid, RA, ischemia,alendronate, glucose
ErbB4		ZCWPW1, FLJ10057	human	7q22.1			cc/PWWP			ErbB4
Prostaglandin	NOV	NOV	human	8q24.1			IB/VWC/TSP1/CT			EP4
IL13	SPRR	SPRR1a	human	1q21-q22			Cornifin			STAT6, IL4, IL13	tangue, tonsil, bradder
		SPRR2A	human	1q21-q22						STAT6, IL4, IL13	bradder, guts
		SPRR2B	human	1q21-q22						STAT6, IL4, IL13

Microarray/proteomics analysis of
infection by	bacterium	*Chlamydia pneumoniae*(intracellular, Gram negative)
		Chlamydia trachomatis
		Enteropathogenic Escherichia coli (intracellular, Gram negative)
		*Helicobacter pylori*(intracellular, Gram negative)
		nontypeable Haemophilus influenzae
		*Listeria monocytogenes* (intracellular, Gram positive)
		*Mycobacterium avium* (intracellular)
		*Mycobacterium tuberculosis*(intracellular)
		Neisseria meningitidis
		Neisseria gonorrhoeae
		*Pseudomonas aeruginosa*(intracellular, Gram negative)
		*Salmonella typhimurium*(intracellular, Gram negative)
		*Salmonella dublin* (intracellular, Gram negative)
		*Streptococcus pneumoniae* (Gram positive)
		*Yersinia enterocolitica*
		*Yersinia pseudotuberculosis*
	protozoa	*Leishmania donovani* (intracellular)
		Leishmania major
		Schistosoma mansoni
		Trypanosoma cruzi
		*Toxoplasma gondii*(intracellular)
	helminth	*Brugia malayi*
	virus	Adenovirus
		Avian Pneumovirus
		Coxsackievirus B3(ssRNA, enterovirus)
		dengue virus
		Hepatitis C Virus(ssRNA, hepacivirus), HCV vs HBV
		HIV-1(retrovirus)
		Herpes simplex virus(dsDNA, HV)
		human herpes virus 8
		Marej's disease virus(dsDNA, HV)
		Modified vaccinia virus Ankara (ds DNA, MVA)
		Epstein-barr virus
		Papillomavirus 11(dsDNA, PV)
		Papillomavirus type 16 E6
		Respiratory syncytial virus
		simian immunodeficiency virus
by	pathogen components	Hepatitis B virus x protein
		KF1B (Nod1 ligand)
		LPS (TLR4 ligand), sBLP (TLR2 ligand), MDP(Nod2 ligand), CpG (TLR9 ligand), flagellin (TLR5 ligand)
		ds RNA (TLR3/CIAS1 ligand), ds B-DNA
with	general staffs	gram neg. & pos. bacteria, virus, PAMPs in macrophages
Review		Signatures of the Immune Response (Shaffer et al., Cell 2001)