Index Caspase CARD/DED/BIR Bcl-2  DD TNF/TNFR Kinases ILs Viral Lipid Engulf TF RING Toll Other Apop Other NFkB Alphabet

Other Apoptosis Regulators
(See NFkB and Apoptosis Regulators, Kinases, too)
 
 
Group NameAGFBP KO gene locus Apoptosis Binding Partner Structure 3D gene regulators memo
AIF AIF(human, mouse, rat) 1 1 Xq25-q26
induce
 Hsp70, DNA oxidoreductase component? 1 TGFb, E2F1, HIV

AMID, PRG3(human)


induce
oxidoreductase component?
p53
Mitochondiral Cytochrome c(human) L
7p15.2
mediate
 Apaf-1, InsP3R
L c-Myc, NRF1, IFNs, T3, CD3/CD28, UVB, PTEN, estrogen, irrad, Expi, AraC, Isoproterenol

Smac, Diablo(human, mouse) 1 1 12q24.31
promote
 IAPs, LTbR, NADE
 TransitPep/alpha/coiled-coil 1, w/IAP
Ub

HtrA2, Omi, PRSS25 (human)

2p12
promote
 IAPs, PEA15
 TransitPep/Ser protease/PDZ 1


TSAP6, dudulin 2 (human)


enhance
 Nix, Myt1

p53
Ankyrin R P DAP-1(human), zebrafish(Dap1a, Dap1b), C.e(T28F4.5, F54B8.4)., fly
1,2 5p15.2
promote
 TNFR1 NO Ank
IFNg, Stat4

FEM-1(C.e., human, mouse)
1 15q22
induce
 CED4 Ank x6



for rel/NF-kB family see TF.








DAP-3 DAP-3/IRRCP(human), C14A4.2(C.e, AF058329)
1,2 1q21
promote
 GR, FADD(-)
 ATP
AgII, cisplatin, phenytoin, IFNa mitochondrial ribosomal proteins
eIF4E eIF4E  (human)


inhibit


UVA

DAP-5(human)
1 11p15
protect
eIF4G

casp
Granzyme Granzyme B(human),CCPI(mouse)
1 14q11.2
promote
Ser protease
CD30,Yp, IFNa
SMN SMN(human,mouse,rat,dog,bovine), C41G7.1 (C.elegans),C2G11.08C(yeast)
1
 1 5q12.2-q13.3
inhibit
 Bcl-2, p53 splicing factors 1 CREB1
DIO-1 DIO-1(human partial, mouse)
1 20q13.3
induce
TF, ZnFx2
IL3, Myc
DAXX human, mouse, zebrafish, Dm
1
 1 18, 6p21.3
promote
 ATRX, DMAP1, Fas, CENT-C, HSF1, Pax3, Pml, MSP58, Pax5, Ets

p53, IFNb, IGF-1, LPS, LTA, Lm, LLO, HHT Sumo
FAIM human, mouse, rat, C. elegans, fly
1
inhibit




DFF DFF45, DFF35, DFFA (human), ICAD(mouse L, S), rat S
L
 1 1p36.3-p36.2
inhibit 
 CAD/DFF40
 CIDE-N/DFF-C, DFF-C 1, 40N/45N, DFF-C IFNg, Nef, Mad1, RA, PPARb, HCV core, irrad casp 3

CAD, DFF40, CPAN, DFFB, (human, mouse, chicken, zebrafish), DREP4 , dCAD(fly, Ag)
L
 1 1p36.3
promote
 ICAD(DREP1)/DFF45, DNA, DFF40, TopoIIa, hsp70 CIDE-N/DNase 1, N, 40N/45N c-Myc, Mad1, IL6, irrad.

CIDE-A (human, mouse), zebrafish
1
 1 18p11.1
induce
 UCP1 CIDE-N/CIDE-C
LPS, PPARb, PPARg1, GnRH, A2aR, IL4/IL5, Expi, KCl

CIDE-B (human, mouse)
1 14p11
induce
 NS2 CIDE-N/CIDE-C CIDE-N PPARb, PPARg1, HNF4a, NO

Fsp27, CIDE3 (human, mouse)
1
 1 3p26.3
induce
CIDE-N/CIDE-C
C/EBP, A2aR

DREP-1 (Fly.Ag)
1 2R
inhibit
 DREP-2 CIDE-N/DFF-C



DREP-3 (Fly)
1 2R
DREP-2 ?/CIDE-N/DFF-C



DREP-2 (Fly, Ag)
1 2R
DREP-1,3 CIDE-N


DNase II DNase II (human, mouse, Ts, FPV), C.e [NUC1, C07B5.5, K04H4.6]   1 19p13.2-q13.4

Pro/DNase


Endonuclease G Endonuclease G(human), cps-6(C.elegans)

9q34.1

Sig/DNase
Ret
AP endonuclease Ape1, APEX, REF1 (human)

14q12
involved
DNase

casp-3
TFIIH ERCC2, XPD, EM9 (human)
TTD 19q13.3 mediate p53 DEAD/helicase
HBx, cantharidin

ERCC3, XPB, XP2 (human)

2q21 mediate p53 DEAD/helicase
HBx
Acinus Acinus('human L,S,S', mouse S, S'), C.elegans, A.thaliana 1 1 14p11.1-2
n.c.
SAP/RNP


DAD-1 human, mouse, chicken,X.laevis, C. elegans,  A. thaliana,yeast(S.p.,S.c.)  1,2 1 14q11-q12
inhibit
 Other oligosasaccharyl treansferase , Mcl1 TM
HBx, CD3/CD28,  b-glucan, Ld, Hp, Ma, SDF1, Subst.P, HCV core, HHT, irrad
BAP31/CDM/ human, mouse, yeast(S.cYDL072c., S.p.), Aspergillus, fly, C.elegans
1 Xq28
promote?
 IgD, Bcl-xL, casp8, PTPLB
 (TM)x3 /coiled-coil
Hp chaperone, casp

BAP29(human, mouse), yeast(S.c.YMR040w)
1 7q22.2
IgD (TM)x3


Bit1 Bit1, CGI-147 (human)

17q23.2
induce
TM


TLE AES (human)

19p13.3
induce
TLE_N



TLE1 (human)

9q21.32
inhibit
TLE_N/WD40x7



TLE2 (human)

19p13.3






TLE3 (human)

15q22





reaper  Rpr(Dm) L 1
induce
 IAPs, Scythe rpr-homo
p53 Ub

Hid(Dm) L 1
induce
 IAPs rpr-homo
Hippo

Grim(Dm) L 1
induce
 IAPs rpr-homo/GH3


Doom D.m., mod(mdg4)


promote
 IAP BTB


HUNTINGTIN HUNTINGTIN(human, D.m.) 1 m 4p16.3
mt:induce
 Hip1



Hip1 HIP1(human) 1
7q11.23
induce
 clathrin, Huntingtin, Hippi, Caspase-8, AP-2 ENTH/Clathrin/AP2/coiled-coi/ILWEQ
(no DED!)


Sir2 hSir2/sirtuin/SIR2alpha (human)

10cen-q26.11 potentiate




TR2L mouse


promote
FE65-like


Son3 human

21q22.1-q22.2
(inhibit)
Collagen/G patch/DSRM


BRCA2 BRCA2 (human) L
13q12.3
(-)
BRCA2Rs
LPS, MDP, LTA
PHAP PHAP1, LANP, MAPM, PP32, PHAPI, I1PP2A (human)

15q22.3-q23
promote
 HLA DR-alpha




PHAP2 (human)



HLA DR-alpha, ataxin-1




prothymosin alpha (human)

2q35-q36
inhibit




Group Name KO gene locus Apoptosis Binding Partner Structure 3D gene regulators memo
GADD45(repair) GADD45a (human, mouse) L 1 1p34-p12
 (-)
 PCNA, MEKK4, CDC2, GADD45a RAD1
p53, c-Myc, Oct-1, PPARg, NF-YA, IL5, IL6, IL10, IL24, OX40, insulin, IGF-II, AgII, g-irrad, UV, NO, hypoxia, T3, ER stress, BRCA1, CD28, LPS, MeDNA, LMP1, FVIIa, p38, TGFb, ALK1, Isoproterenol, Ye, YopP, TSH, PTH, TRRAP inhibit JNK

GADD45b, MyD118(human, mouse) L 1  19p13.3
mediate/inhibit/ (-)
 PCNA,MEKK4, MKK7, p21WAP1

NF-kB, p53, CLOCK, IL6, IL10, TCR, PMA, CD40, GnRH, LPS, MeDNA, hsp65, OX-CA, Ld, Lm, Mt, Tg, AdV, M-CSF, ER, RANKL, TGFb, UVB, hypoxia inhibit NF-kB

GADD45g, GRP17, CR6, OIG37 (human) L
9q22.1-q22.2
(-)
 PCNA, MEKK4

AP1, ATF3, IL2, IL12, IL10, OSM, Fas, Myc
GADD34 GADD34/PPP1R15A(human) 1 1 19q13.2
induce
 BAG1

TNFa, LPS, IL10, UVB, FceRI, MeDNA
RAD21 RAD21 (human)

8q24 (mediate?)


Lm casp, Esp1

Rec8p (human)

14q11.2-q12






RAD21L1 (human)

20p13





Rad9 Rad9A (human)

11q13.1-q13.2
induce/inhibit
 HUS1, RAD1, Bcl-2, Bcl-xL


casp

Rad9B (human)

12q24.13
HUS1, RAD1, RAD17, HUS1B



MutS MSH6, GTBP, HNPCC5 (human) L
2p16
modulate





DDB1, DDBA, XAP1, XPCE, XPE-BF, UV-DDB1 (human)








FANCD2 FANCD2 (human)

3p25.3
inhibit
 TNFR1, TNFR2


monoUb
ADAR1 ADAR, ADAR1 (human) L, DSH
1q21.1-q21.2
regulate?




MBD MBD4 (human) 1 1 3q21-q22
mediate
 MLH1, FADD



WW45 WW45 (human), Salvador/sav (Dm)

14q13-q23
promote
WW/ cc
Warts
ATM ATM (human, mouse) L
11q22-q23
mediate
FAT/PI3K/FATC
heat shock, Subst.P, RA p53 S376, casp

FRP1, ATR (human) 1
3q22-q24
inhibit
FATx2/PI3K/FATC
irrad

TRRAP, PAF400 (human, Dm) 1
7q21.2-q22.1
(-)
 c-Myc, E2F1, PCAF, GCN5 FATx2/PI3K/FATC

see HAT, targets

FRAP, FRAP1, mTOR, RAFT1 (human)

1p36.2
mediate
 FKBP12, Raptor, phosphatidic acid, armadillo/FAT/PI3K/FATC


TIP49 TIP49, NMP238,  pontin 52, ECP54, RUVBL1 (human)

3q21
mediate
 c-Myc AAA



TIP48, ECP51, RUVBL2 (human)

19q13.3
c-Myc AAA


NIPs NIP2(human), c.f. NIP1,NIP3 subfamily was moved into list of Bcl-2 family
1 15q21.2-3
Bcl-2, E1B 19K, Cdc42GAP rhoGAP-N domain
DEX
beclin human[GT197], mouse, S.p.[C3A12.01C], S.c.[Lph7p]
1 17q21
Bcl-2 coiled-coil


Ubiquitin-like SUMO-1 human(SUMO-1/SMT3C, SMT3A, SMT3B), list 1 1 2q32.2-q33 
mdm2 Ub-like 1 p53 review

diubiquitin/FAT10(human)

6p21.3
induce


IFNg, TNFa

FAF1 (human, mouse, C.e)
1 1p33
inhibit/promote
 Fas, p65 Ub x2 1

Ubiquitin-linked p193(human)
1 15q13
induce
 T-ag E3 HECT/cullin(no BH3!)


Ku70 Ku70, G22P1,TLAA (human) L 1 22q13.2-q13.31
inhibit
 ds breaks, DNA-PKc, Bax
1 irrad., O stress, NF-kB; PCAF/CBP

Ku80, XRCC5 (human) 1
2q35

VWA/Ku-N/Ku-C
O stress DNA helicase II,

PERP,  KCP1 THW,, PIGPC1 (human)






p53, IL5
Group Name KO gene locus Apoptosis Binding Partner Structure 3D gene regulators memo
Hsp activator BAG1, RAP46 (human,mouse,list) 1 1 9p12
inhibit
 Bcl-2, GR, RAR, AR,Siah, Hsp70, Hsc70, GADD34, HGFR, VDR, HD
 Ub-like+BAGD w/Hsc70 p53, IL3, FGF2, IFNa, IFNb, IFNg, UV, prolactin, TCR, CD4, estrogen, D3 Ub

BAG2 (human)
1 6p12.3-p11.2
Hsc70/ATPase BAGD
TGFb

BAG3/Bis(human, mouse)
1 10q25
inhibit
 Hsc70/ATPase, Bcl-2 WW+BAGD
SEL1L

BAG4/SODD (human) 1L 1 8q11
Hsc70/ATPase, TNFR1 BAGD L RANTES

BAG5(human)
1 14?, 1p36.3
ricin BAGD
UVB, EV71

Scythe/BAT3 (human)
1 6p21.3
induce
 reaper Ub-like



UNC23(C.e.)




BAG2-like


BAT3 BAT3, D6S52E (human)

6p21.3
inhibit
Ub/Extensin
TNFa
 casp3
FANCC FANCC (human) L
9q22.3
inhibit
 Hsp70, Hsp40, PKR



BI-1/TEGT human, mouse,  rat, AtBI-1(A.thaliana), E.coli[YCCA etc], other bacteria(H.i.,Pa, Hpetc]
1 12q12-q13
inhibit
 Bcl-2, Bcl-xL UPF0005(TMx6) TNFa


LFG/Lifeguard(human)
1 12q13
inhibit
 Fas




NMDARA1[rat, Dm]C.e.[F40F9.2], Cowpox Virus[S1R]








Amida fb1/Amida (human, mouse, rat) 1 1 19q13.4
induce?
 Arc



MAJN TIAF1/MAJN(human)
1 17 or 18
inhibit
 Jak3 no conserved(see memo)
camptothecin,