Other Apoptosis Regulators
(See NFkB and Apoptosis Regulators, Kinases, too)
 
 

Group	NameAGFBP	KO	gene	locus	Apoptosis	Binding Partner	Structure	3D	gene regulators	memo
AIF	AIF(human, mouse, rat)	1	1	Xq25-q26	induce	Hsp70, DNA	oxidoreductase component?	1	TGFb, E2F1, HIV
	AMID, PRG3(human)				induce		oxidoreductase component?		p53
Mitochondiral	Cytochrome c(human)	L		7p15.2	mediate	Apaf-1, InsP3R		L	c-Myc, NRF1, IFNs, T3, CD3/CD28, UVB, PTEN, estrogen, irrad, Expi, AraC, Isoproterenol
	Smac, Diablo(human, mouse)	1	1	12q24.31	promote	IAPs, LTbR, NADE	TransitPep/alpha/coiled-coil	1, w/IAP		Ub
	HtrA2, Omi, PRSS25 (human)			2p12	promote	IAPs, PEA15	TransitPep/Ser protease/PDZ	1
	TSAP6, dudulin 2 (human)				enhance	Nix, Myt1			p53
Ankyrin R P	DAP-1(human), zebrafish(Dap1a, Dap1b), C.e(T28F4.5, F54B8.4)., fly		1,2	5p15.2	promote	TNFR1	NO Ank		IFNg, Stat4
	FEM-1(C.e., human, mouse)		1	15q22	induce	CED4	Ank x6
	for rel/NF-kB family see TF.
DAP-3	DAP-3/IRRCP(human), C14A4.2(C.e, AF058329)		1,2	1q21	promote	GR, FADD(-)	ATP		AgII, cisplatin, phenytoin, IFNa	mitochondrial ribosomal proteins
eIF4E	eIF4E  (human)				inhibit				UVA
	DAP-5(human)		1	11p15	protect		eIF4G			casp
Granzyme	Granzyme B(human),CCPI(mouse)		1	14q11.2	promote		Ser protease		CD30,Yp, IFNa
SMN	SMN(human,mouse,rat,dog,bovine), C41G7.1 (C.elegans),C2G11.08C(yeast)	1	1	5q12.2-q13.3	inhibit	Bcl-2, p53	splicing factors	1	CREB1
DIO-1	DIO-1(human partial, mouse)		1	20q13.3	induce		TF, ZnFx2		IL3, Myc
DAXX	human, mouse, zebrafish, Dm	1	1	18, 6p21.3	promote	ATRX, DMAP1, Fas, CENT-C, HSF1, Pax3, Pml, MSP58, Pax5, Ets			p53, IFNb, IGF-1, LPS, LTA, Lm, LLO, HHT	Sumo
FAIM	human, mouse, rat, C. elegans, fly		1		inhibit
DFF	DFF45, DFF35, DFFA (human), ICAD(mouse L, S), rat S	L	1	1p36.3-p36.2	inhibit	CAD/DFF40	CIDE-N/DFF-C, DFF-C	1, 40N/45N, DFF-C	IFNg, Nef, Mad1, RA, PPARb, HCV core, irrad	casp 3
	CAD, DFF40, CPAN, DFFB, (human, mouse, chicken, zebrafish), DREP4 , dCAD(fly, Ag)	L	1	1p36.3	promote	ICAD(DREP1)/DFF45, DNA, DFF40, TopoIIa, hsp70	CIDE-N/DNase	1, N, 40N/45N	c-Myc, Mad1, IL6, irrad.
	CIDE-A (human, mouse), zebrafish	1	1	18p11.1	induce	UCP1	CIDE-N/CIDE-C		LPS, PPARb, PPARg1, GnRH, A2aR, IL4/IL5, Expi, KCl
	CIDE-B (human, mouse)		1	14p11	induce	NS2	CIDE-N/CIDE-C	CIDE-N	PPARb, PPARg1, HNF4a, NO
	Fsp27, CIDE3 (human, mouse)	1	1	3p26.3	induce		CIDE-N/CIDE-C		C/EBP, A2aR
	DREP-1 (Fly.Ag)		1	2R	inhibit	DREP-2	CIDE-N/DFF-C
	DREP-3 (Fly)		1	2R		DREP-2	?/CIDE-N/DFF-C
	DREP-2 (Fly, Ag)		1	2R		DREP-1,3	CIDE-N
DNase II	DNase II (human, mouse, Ts, FPV), C.e [NUC1, C07B5.5, K04H4.6]		1	19p13.2-q13.4			Pro/DNase
Endonuclease G	Endonuclease G(human), cps-6(C.elegans)			9q34.1			Sig/DNase		Ret
AP endonuclease	Ape1, APEX, REF1 (human)			14q12	involved		DNase			casp-3
TFIIH	ERCC2, XPD, EM9 (human)		TTD	19q13.3	mediate	p53	DEAD/helicase		HBx, cantharidin
	ERCC3, XPB, XP2 (human)			2q21	mediate	p53	DEAD/helicase		HBx
Acinus	Acinus('human L,S,S', mouse S, S'), C.elegans, A.thaliana	1	1	14p11.1-2	n.c.		SAP/RNP
DAD-1	human, mouse, chicken,X.laevis, C. elegans,  A. thaliana,yeast(S.p.,S.c.)	1,2	1	14q11-q12	inhibit	Other oligosasaccharyl treansferase , Mcl1	TM		HBx, CD3/CD28,  b-glucan, Ld, Hp, Ma, SDF1, Subst.P, HCV core, HHT, irrad
BAP31/CDM/	human, mouse, yeast(S.cYDL072c., S.p.), Aspergillus, fly, C.elegans		1	Xq28	promote?	IgD, Bcl-xL, casp8, PTPLB	(TM)x3 /coiled-coil		Hp	chaperone, casp
	BAP29(human, mouse), yeast(S.c.YMR040w)		1	7q22.2		IgD	(TM)x3
Bit1	Bit1, CGI-147 (human)			17q23.2	induce		TM
TLE	AES (human)			19p13.3	induce		TLE_N
	TLE1 (human)			9q21.32	inhibit		TLE_N/WD40x7
	TLE2 (human)			19p13.3
	TLE3 (human)			15q22
reaper	Rpr(Dm)	L	1		induce	IAPs, Scythe	rpr-homo		p53	Ub
	Hid(Dm)	L	1		induce	IAPs	rpr-homo		Hippo
	Grim(Dm)	L	1		induce	IAPs	rpr-homo/GH3
Doom	D.m., mod(mdg4)				promote	IAP	BTB
HUNTINGTIN	HUNTINGTIN(human, D.m.)	1	m	4p16.3	mt:induce	Hip1
Hip1	HIP1(human)	1		7q11.23	induce	clathrin, Huntingtin, Hippi, Caspase-8, AP-2	ENTH/Clathrin/AP2/coiled-coi/ILWEQ (no DED!)
Sir2	hSir2/sirtuin/SIR2alpha (human)			10cen-q26.11	potentiate
TR2L	mouse				promote		FE65-like
Son3	human			21q22.1-q22.2	(inhibit)		Collagen/G patch/DSRM
BRCA2	BRCA2 (human)	L		13q12.3	(-)		BRCA2Rs		LPS, MDP, LTA
PHAP	PHAP1, LANP, MAPM, PP32, PHAPI, I1PP2A (human)			15q22.3-q23	promote	HLA DR-alpha
	PHAP2 (human)					HLA DR-alpha, ataxin-1
	prothymosin alpha (human)			2q35-q36	inhibit

Group	Name	KO	gene	locus	Apoptosis	Binding Partner	Structure	3D	gene regulators	memo
GADD45(repair)	GADD45a (human, mouse)	L	1	1p34-p12	(-)	PCNA, MEKK4, CDC2, GADD45a	RAD1		p53, c-Myc, Oct-1, PPARg, NF-YA, IL5, IL6, IL10, IL24, OX40, insulin, IGF-II, AgII, g-irrad, UV, NO, hypoxia, T3, ER stress, BRCA1, CD28, LPS, MeDNA, LMP1, FVIIa, p38, TGFb, ALK1, Isoproterenol, Ye, YopP, TSH, PTH, TRRAP	inhibit JNK
	GADD45b, MyD118(human, mouse)	L	1	19p13.3	mediate/inhibit/ (-)	PCNA,MEKK4, MKK7, p21WAP1			NF-kB, p53, CLOCK, IL6, IL10, TCR, PMA, CD40, GnRH, LPS, MeDNA, hsp65, OX-CA, Ld, Lm, Mt, Tg, AdV, M-CSF, ER, RANKL, TGFb, UVB, hypoxia	inhibit NF-kB
	GADD45g, GRP17, CR6, OIG37 (human)	L		9q22.1-q22.2	(-)	PCNA, MEKK4			AP1, ATF3, IL2, IL12, IL10, OSM, Fas, Myc
GADD34	GADD34/PPP1R15A(human)	1	1	19q13.2	induce	BAG1			TNFa, LPS, IL10, UVB, FceRI, MeDNA
RAD21	RAD21 (human)			8q24	(mediate?)				Lm	casp, Esp1
	Rec8p (human)			14q11.2-q12
	RAD21L1 (human)			20p13
Rad9	Rad9A (human)			11q13.1-q13.2	induce/inhibit	HUS1, RAD1, Bcl-2, Bcl-xL				casp
	Rad9B (human)			12q24.13		HUS1, RAD1, RAD17, HUS1B
MutS	MSH6, GTBP, HNPCC5 (human)	L		2p16	modulate
	DDB1, DDBA, XAP1, XPCE, XPE-BF, UV-DDB1 (human)
FANCD2	FANCD2 (human)			3p25.3	inhibit	TNFR1, TNFR2				monoUb
ADAR1	ADAR, ADAR1 (human)	L, DSH		1q21.1-q21.2	regulate?
MBD	MBD4 (human)	1	1	3q21-q22	mediate	MLH1, FADD
WW45	WW45 (human), Salvador/sav (Dm)			14q13-q23	promote		WW/ cc		Warts
ATM	ATM (human, mouse)	L		11q22-q23	mediate		FAT/PI3K/FATC		heat shock, Subst.P, RA	p53 S376, casp
	FRP1, ATR (human)	1		3q22-q24	inhibit		FATx2/PI3K/FATC		irrad
	TRRAP, PAF400 (human, Dm)	1		7q21.2-q22.1	(-)	c-Myc, E2F1, PCAF, GCN5	FATx2/PI3K/FATC			see HAT, targets
	FRAP, FRAP1, mTOR, RAFT1 (human)			1p36.2	mediate	FKBP12, Raptor, phosphatidic acid,	armadillo/FAT/PI3K/FATC
TIP49	TIP49, NMP238,  pontin 52, ECP54, RUVBL1 (human)			3q21	mediate	c-Myc	AAA
	TIP48, ECP51, RUVBL2 (human)			19q13.3		c-Myc	AAA
NIPs	NIP2(human), c.f. NIP1,NIP3 subfamily was moved into list of Bcl-2 family		1	15q21.2-3		Bcl-2, E1B 19K, Cdc42GAP	rhoGAP-N domain		DEX
beclin	human[GT197], mouse, S.p.[C3A12.01C], S.c.[Lph7p]		1	17q21		Bcl-2	coiled-coil
Ubiquitin-like	SUMO-1 human(SUMO-1/SMT3C, SMT3A, SMT3B), list	1	1	2q32.2-q33		mdm2	Ub-like	1	p53	review
	diubiquitin/FAT10(human)			6p21.3	induce				IFNg, TNFa
	FAF1 (human, mouse, C.e)		1	1p33	inhibit/promote	Fas, p65	Ub x2	1
Ubiquitin-linked	p193(human)		1	15q13	induce	T-ag	E3 HECT/cullin(no BH3!)
Ku70	Ku70, G22P1,TLAA (human)	L	1	22q13.2-q13.31	inhibit	ds breaks, DNA-PKc, Bax		1	irrad., O stress, NF-kB; PCAF/CBP
	Ku80, XRCC5 (human)	1		2q35			VWA/Ku-N/Ku-C		O stress	DNA helicase II,
	PERP,  KCP1 THW,, PIGPC1 (human)								p53, IL5

Group	Name	KO	gene	locus	Apoptosis	Binding Partner	Structure	3D	gene regulators	memo
Hsp activator	BAG1, RAP46 (human,mouse,list)	1	1	9p12	inhibit	Bcl-2, GR, RAR, AR,Siah, Hsp70, Hsc70, GADD34, HGFR, VDR, HD	Ub-like+BAGD	w/Hsc70	p53, IL3, FGF2, IFNa, IFNb, IFNg, UV, prolactin, TCR, CD4, estrogen, D3	Ub
	BAG2 (human)		1	6p12.3-p11.2		Hsc70/ATPase	BAGD		TGFb
	BAG3/Bis(human, mouse)		1	10q25	inhibit	Hsc70/ATPase, Bcl-2	WW+BAGD		SEL1L
	BAG4/SODD (human)	1L	1	8q11		Hsc70/ATPase, TNFR1	BAGD	L	RANTES
	BAG5(human)		1	14?, 1p36.3		ricin	BAGD		UVB, EV71
	Scythe/BAT3 (human)		1	6p21.3	induce	reaper	Ub-like
	UNC23(C.e.)						BAG2-like
BAT3	BAT3, D6S52E (human)			6p21.3	inhibit		Ub/Extensin		TNFa	casp3
FANCC	FANCC (human)	L		9q22.3	inhibit	Hsp70, Hsp40, PKR
BI-1/TEGT	human, mouse,  rat, AtBI-1(A.thaliana), E.coli[YCCA etc], other bacteria(H.i.,Pa, Hpetc]		1	12q12-q13	inhibit	Bcl-2, Bcl-xL	UPF0005(TMx6)	TNFa
	LFG/Lifeguard(human)		1	12q13	inhibit	Fas
	NMDARA1[rat, Dm]C.e.[F40F9.2], Cowpox Virus[S1R]
Amida	fb1/Amida (human, mouse, rat)	1	1	19q13.4	induce?	Arc
MAJN	TIAF1/MAJN(human)		1	17 or 18	inhibit	Jak3	no conserved(see memo)		camptothecin, Hi	in KIAA0216 3'
BRCC2	BRCC2 (human)			11q24.1						no other mammal homologue
CAS	CAS, CSE1, CSE1L (human)		1	20q13	inhibit		importin/CAS		Nef, Csx,	nuclear transport
methylase	Anamorsin, LOC57019 (human)	1		16q13-q21	inhibit		methylase/DUF689
Aac11	Aac11, API5, FIF(human,mouse,A.thaliana)		1	11p12-q12	inhibit				Fas, camptothecin
IGFBP-3	IGFBP-3 (human)		1	7p13-p12	promote		IGFBP/TY		AIRE, LPS, PMA, SCF, AgII, CSV-B3, RA, HOXD3, M-CSF, TGFb, cisplatin, estrogen, hypoxia, A2aR
TPT1	fortilin, HRF, TPT1 (human)			13q12-q14	inhibit		TCTP
gelsolin	gelsolin(human)		1	9q34	inhibit		Tax	L	5FU, Mt
TDAG51	TDAG51, PHLDA1 (human,mouse;partial)		1	12q15-q21.2	(promote?)		IPL related		IGF-1, insulin, Hp, PMA
RNA-BP	MCG10, PCBP4 (human, mouse)		1	3p21	induce		KHx2/PRDx3+NES/NLS		p53
	PACT, RAX, PRKRA (human)			2q31.3	enhance	dsRNA, PKR	dsRNABDx3
FAST	FAST(human)		1	7q35		TIA1	CCP2-like		cisplatin
p52	p52, PAP, PDCD9, MRP-S30 (chicken, human, mouse,  fly)		1	5q11	induce					mitochondrial ribosomal proteins
ALGs	ALG2, ALG3, STM-2, presenilin-2/E5-1/AD3LP/AD5(human, rat, mouse, D.m.), X.l.[a,b], C.e.[Spe-4, SEL-12], A. thaliana[F22O13.19]	L	1	5p15.2-pter	promote	AIP1, SETA, Bcl-xL	TMx9	1	TCR , LPS, Ld, IRF4, Subst.P	casp
	presenilin-1/PSEN1/PS1(human, mouse)	L	1, KI	14q24.3	affect	Bcl-2, Bcl-xL, PSAP			PTEN, Subst.P, LPS	targets, casp
	PSAP (human)			6pter-p24.1	induce	PS1	mito_carr x2
AIP1	AIP1, Alix, PDCD6IP (human, mouse)		1	3p22.1	(mediate?)	ALG2, SETA	BRO1/YNK1-like		E2F1, estrogen	vacuolization
ES18	ES18, PCD7 (human, mouse)		1	15q22.1	promote		cc
mda-7	mda-7(human), c49a(rat)		1	1q31	induce
CDKI	p14ARF(human),p16/INK4/INK4a/CDKN2A/MTS1(human)		1	9p21	mediate	MDM2,CDKs		L	DMP1,E1A
ANT	ANT1 (human)		1	4q35	induce	other PT pore comp, bax, IkBa	TM		c-Myc, Hp
Aven	Aven (human)		1	15q13.1	inhibit(?)	Apaf-1,Bcl-xL, vBcl-2	AD
ING	human ING1(p33, p47ING1a, p33ING1b, p24ING1c )			13q34	induce	p53, A1	PHD
	p33ING2(human, mouse)			Xq12	induce	p53			DNA damage
	ING3(human)			7q31			cc/PHD
	human LOC51147, my036			12pter-p13.31			cc/PHD
p53AIP1	p53AIP1(human)		1	11q23-24	induce
p53DINP1	p53DINP1(human a,b), mouse(TEAP/SIP27, SIP18)			8q22	mediate				p53, stress
	dJ1181N3.1, C20orf110 (human)			20q11.22
Viaf1	Pdcl2, Viaf1(zebrafish), tPhLP(mouse), MGC35083(human), fly, A.t., S.p.			4q12	(promote)	OpIAP	phosducin-like
MAGE	NRAGE(human, rat)			Xp11.23	induce	p75NTR, XIAP
GRIM19	GRIM19(human,mouse), CG3446(fly), C34B2.8(C.e.), At2g33220(A.t.)			19p13.2	mediate	vIRF1, STAT3			TNFa	IFNb
TCTP	TCTP/HRF/fortilin(human), S.c.			13q12-q14	inhibit		TCTP
	FKSG2(human)			8p11.2	inhibit		TCTP
lipocalin	lipocalin 1(human)			9q34		hydrophobic ligands	Lipocalin		HCV
	lipocalin 2/24p3/NGAL, LCN2 (human)			9q34	induce		Lipocalin		NF-IL6, IFNa, IL3, IKKs, HCV, LMP1, A2aR
	OBP2A(human)			9q34			Lipocalin	L
	OBP2B(human)			9q34			Lipocalin
	AMBP(human)			9q32-q33			Lipocalin/Trypsin inhibitors x2
	prostaglandin D2 synthase(human)			9q34.2-q34.3			Lipocalin
	C8gamma(human)			9q34.3			Lipocalin			here, too
cFABP	glycodelin A/PP14(human)			9q34	induce		cFABP
PACAP	PACAP(human, mouse)	1		5q23-5q31		Casp2,9	secreted protein+seq. error
NADE	NADE, BEX, NGFRAP1 (human), mouse, rat, )			Xq22.2	induce	p75NTR, Smac
	BEX1 (human)			Xq21-q23
	BEX2 (human)			Xq22
	LOC340542 (human)			Xq22.1
	LOC340542 (human)			Xq22.1-q22.3
	MGC23947 (human)			Xq22.1
	MGC45400 (human)			Xq22.2
Porimin	porimin(human)			11q22.1	mediate		signal/TM
cohesion, SCC	STAG1, SA1 (human, mouse, frog,)			3q22.3	induce				p53	maintenance of sister chromatid cohesion during cell division
	STAG2, SA2 (human, mouse)			Xq25
	STAG3 (human, mouse)			7q22.1
disabled	DAB2, DOC2 (human)			5p13	induce	(P-Tyr)	PTB
Galectin	Galectin-7/PIG1(human)			19q13.2	induce		Gal-lectin	L	p53	activates JNK
	Galectin-9, LGALS9, ecalectin (human L, S)			17q11.1	induce
SPARC	SPARC, osteonectin (human)	L		5q31.3-q32	induce		Kazal		AP1, bFGF	major bone protein
TPR	FLJ21908 (human, mouse)			12q13.11	induce		cc/TPRx6		HIV
PPI/FKBP	Cyclophilin D, CYP40, PPID (human)			4q31.3		FK506	PPI/TPRx3
	FKBP38, FKBP8 (human)			19p12	inhibit	FK506, Bcl-2, Bclx-L	FKBP/TPRx2			calcineurin inhibitor
	FKBP51, FKBP54, FKBP5 (human)			6p21.3-21.2		kinases (IKKa, IKKe, MEKK1, TAK1)	FKBP/TPRx2		GR, HCV, VDR, estrogen
	FKBPL (human)			6p21.3			TPRx3
	FKBP52, FKBP4 (human)			12p13.33		PHYH	FKBPx2/TPRx2/cc		AIRE, CD3, estrogen, Ret, Myc
	FKBP65, FKBP10 (human)			17q21.2			FKBPx4/EFhx2		BMP2
	FKBP63, FKBP9 (human)			7p11.1			FKBPx4/EFhx2
	FKBP36, FKBP6 (human)			7q11.23			FKBP/TPRx3
	LOC169760 (human)			9p11.2			FKBP/TPRx2
	FKBP12, PKCI2, FKBP1A (human)	1		20p13			FKBP	L	IL13, Yp, HCV	activate NF-kB
	FKBP12.6, FKBP1B (human)	1		2p24.1			FKBP		Brn3a
	FKBP13, FKBP2 (human)			11q13.1-q13.3			FKBP
	FKBP25, FKBP3 (human)			14q21.1	(inhibit?)		FKBP		ER stress, ARNT2
	FKBP11 (human)			12q13.11			FKBP
WW	WWOX, WOX1, FOR (human)			16q23.3-q24.1	mediate		WWx2/ADH
TSC1	TSC1, hamartin  (human)	1		9q34		tuberin,	TSC1/cc
	TSC2, TSC4 (human)	L, Eker		16p13.3	inhibit		TSC1
Ced-8	XK(human), Ced-8(C.e.)	1		Xp21.2-p21.1	(promote)		TM
Ced-11	Ced-11(C.e.)	1					TRP
ced(n3194)	ced(n3194) 2(C.e.), R13A5.1(DNA)				inhibit?		K+/Ca2+-channel

Proteins induced during apoptosis
 

Group	Name	locus	Inducer	Structure
MA-3, TIS	MA-3, PDCD4, TIS (mouse), H731-like(human)	10q24	apoptosis/IL-12(NK)/TIs, GR	eIF-4G
NIPK	NIPK(rat)		NGF-withdrawl	kinase
RP-8	human, mouse, rat		Irradiation/Dex.	ZnF(C2H2)
DIO-1	see the upper table		IL-7-withdrawal, IFNg, Dex., anti-IgM, Myc	TF, ZnFx2
	C.e.[R07E5.10], A.thaliana[T10M13.22], S.p. [SPAC13G6.09]
SCLP	tabbaco hornworm			LRRs

Microarray analysis of

cancer drugs (camptothecin, cisplatin, methorexate, paclitaxel) by Brachat et al. (Oncogene 2002)
irradiation
growth factor deprivation by Brachat et al. (Oncogene 2000, direct link)
neuronal cell death by Chiang et al. (PNAS 2001)
p53-sensitive/resistant cells by Maxwell & Davis (PNAS 2001)

On-line review

BAG proteins by Townsend et al., (Biochim Biophys Acta 2003), Takayama & Reed (Nat. Cell Biol.  2001)
p53  by Agawal et al. (J. Biol. Chem. 1998)
p73 by Oren (Cell 1997),  by Dickman (Science 1997)
p53 family by Kaelin Jr. (Science 1998)

CIDE/DFF family
Induction of apoptosis and DNA fragmentation by CIDEs

Caenorhabditis elegans WWW Server

Copyright by Naohiro Inohara, Department of Pathology, University of of Michigan Medical School