| Subgroup |
Protein Name |
Apoptosis
|
NFkB activation
|
KO |
Structure |
Locus |
3D |
substrates |
(other or undefined) binding partners |
upstream regulators |
memo |
BRCA1 & BRCT
|
BRCA1(human,
mouse,
rat) |
induce
|
|
L |
RING/?/BRCTx2 |
|
L |
BRCA1,
H2A,
H2AX,
H2B,
H3,
H4,
B23 |
UBC4,
UbcH5a,
UBCH5c,
ATF1,
BAP1,
BRAP,
BARD1,
CBP,
CtIP,
Elk-1,
KPNA1,
Lyn,
p53,
RAD50,
53BP1,
IFI16,
BRIP1,
ZBRK1 |
CREB,c-Myc,
E2F6,
GABPs,
Id4,
BRCA1,
FANCD2,
nicotine,
irrrad,
methylation |
bm, gene
targets |
| BARD1(human) |
induce/
inhibit
|
|
|
RING/ANKx3/BRCTx2 |
2q34-q35 |
w/BRCA1 |
|
BRCA1,
p53 |
stress |
bm, calpain |
| 53BP1, TP53BP1 (human,
mouse,
Xenopus) |
mediate
|
|
|
?/BRCTx2 |
15q15-q21 |
w/p53 |
|
p53,
BRCA1 |
ATM,
DNA
damage, |
|
| MDC1, NFBD1 (human) |
mediate
|
|
|
FHA/BRCT |
6pter-p21.31 |
|
|
CHK2 |
MeDNA
|
bm, preB
|
| FLJ12847 (human,
Dm) |
|
|
|
BRCTx2 |
8p23.1 |
|
|
Rho
|
|
NK, B
|
| TOPBP1(human),
MUS101(Dm) |
|
|
|
BRCTx7 |
3q22.2 |
|
|
TopII,
E2F1 |
|
bm, B, T, NK
|
ECT2
(human)
|
|
induce
|
|
BRCTx2/RhoGEF/PH
|
3q26.1-q26.2
|
|
|
|
|
|
| F37D6.1(Ce) |
|
|
|
BRCTx5 |
|
|
|
|
|
|
| At1g04020(At) |
|
|
|
RING/PHD/BRCTx2 |
|
|
|
|
|
|
CBL
|
CBL(human,
mouse,
chicken,
Dm,
Ce) |
inhibit
|
|
L |
SH2(Y-P BD)/RING/ZF/UBA |
11q23.3 |
w/Ubch7 |
PDGFRa,
ErbB1,
Syk,
Lck,
Lyn,
Fyn,
RON,
c-Kit,
TCRzeta,
PI3Kp85,
Hck,
c-Met,
EGFR,
Flk1,
EphA2,
Notch1,
Vav,
p75NTR
|
Ubch7, APC,
SPRY2,
CIN85,
CMS |
cisplatin,
UVA,
HECTs |
|
| CBL-B(human) |
|
|
L |
CBL-N/SH2/RING |
3q13.11 |
|
PI3Kp85,
EGFR, Kit, PDGFR, C3G |
CIN85 |
FKHRL1 |
CD28 |
| CBL-C, CBL3 (human) |
|
|
1 |
CBL-N/RING |
19q13.2 |
|
EGFR |
AIP4,
WWP1 |
|
epithelium
|
| IAPs |
see BIR
proteins |
MDM2
|
Mdm2 (human(hdm2),
mouse,
Xenopus) |
inhibit
|
|
L
|
MDM2/ZF/RING |
12q14.3-q15 |
L |
p53,
p73,
AR,
mdm2,
mdmX,
Numb,
Tip60 |
p19ARF,
mdm4,
p75a, TAFII250,
HDAC1 |
p53,
BRCA1,
c-Myc,
O
stress, NO,
irrad.,
bFGF,
IGF-I,
IGF-II,
Lm, UV,
SUMO-1,
Ubc9;
p38,
Akt,
PLD,
HIPK1,
VSV,
estrogen |
|
| Mdm4/mdmX(human,
mouse) |
promote
|
|
1
|
|
1q32 |
|
p53,
mdmX |
|
N-Myc,
ARNT2 |
|
| TRAF |
TRAFs, TRAF-related proteins
(including TRIM37), see "other
NF-kB regulators"
|
| TRIP |
see "other
NF-kB regulators"
|
| MEKK1 |
see kinases
|
| Siah-1 |
Siah-1(human),
Sina (Dm) |
promote
|
|
L |
RING/ZFx2/TRAF-C-like |
16q12 |
1 |
rpvaxVxPxxr,
b-catenin, Kid,
DCC,
BAG1, Myb, N-CoR, synphilin-1,
CtIP,
Numb,
Tramtrack |
BAG-1,
mGluR,Ubc9, UbcH5, PHYL, Vav, a-tublin, SIP, polycystin-1,
PEG10,
Phyllopod,
Ebi |
p53,
insulin,
disabled1,
LPS |
Ras-dep. |
|
Siah-2(human) |
promote
|
|
L |
RING/TRAF-C-like |
3q25 |
|
TRAF2 |
Vav, |
|
|
| Multi-RING |
parkin, Park2 (human,
mouse) |
supress
|
|
|
UBQ/RING/(IBR)/RING/(IBR) |
6q25.2-q27 |
L |
CDCrel-1,
a-synuclein,
synphilin-1,
aminoacyl-tRNA
synthetase |
UbcH7,
UbcH8,
CHIP, Hsp70, Rpn10
|
FLRF
|
casp,
leprosy suscept. |
|
ariadne, UBCH7BP, HHARI, ARIH1, UIP77 (human,
Dm) |
|
|
Dm |
?/RING/(IBR)/RING/(IBR)/? |
15q24 |
|
4EHP |
UbcH7,
UbcH8,
UbcM4 |
|
|
|
TRIAD1, ARIH2, ariadne-2, UIP48 (human,
mouse) |
|
|
|
?/RING/(IBR)/RING/(IBR)/RING/(IBR)/? |
3p21.2-p21.3 |
|
|
UbcM4 |
hypoxia,
Blimp1 |
|
|
ARA54, HFB30, RNF14 (human) |
|
|
|
RWD/RING/(IBR)/RING/(IBR) |
5q23.3-q31.1 |
|
|
AR |
|
|
|
KIAA0161 (human) |
|
|
|
RING/(IBR)/RING/(IBR)/RING |
2p25.3 |
|
|
|
|
|
|
RNF144 (human,
mouse) |
|
|
|
RING/(IBR)/RING |
2p25.2 |
|
|
|
|
|
|
dorfin, RNF19 (human) |
inhibit?
|
|
|
RING/(IBR)/RING/(IBR)/TMx2? |
8q22 |
|
synphilin-1 |
Sp1 |
AdV,
Ret
|
|
|
C20orf18 (human) |
|
|
|
UBQ/ZF/RING |
20p13 |
|
|
|
|
|
|
XAP3, UIP28, HOIL-1,
RBCK1, C20orf18 (human) |
|
|
|
UBQ/ZF/RING/(IBR)/RING/(IBR) |
20p13 |
|
ox.IRP2 |
UbcM4,
HBV-X,
PKCbI |
|
|
|
TRIAD3, UIP83, ZIN (human) |
|
|
|
RING/(IBR)/RING/(IBR) |
7p22.2 |
|
TLRs
|
RIP |
|
|
|
ZIBRA, RNF31 (human) |
|
|
|
RING/(IBR)/RING |
14q11.2 |
|
|
|
|
|
|
p53RFP, IBRDC2 (human,
mouse,
zebrafish) |
|
|
|
RING/(IBR)/RING |
6p22.3 |
|
|
|
p53 |
|
PDZ
|
LNX(human,
mouse) |
|
|
|
RING/PDZx4 |
4q11 |
|
Numb |
|
|
|
| LNX2, MGC46315 (human) |
|
|
|
RING/PDZx4 |
13q12.13 |
|
|
|
|
|
PDZRN3 (human)
|
|
|
|
RING/PDZx2/cc |
3p14.1
|
|
|
|
|
|
LNX4, PDZRN4 (human)
|
|
|
|
RING/PDZx2/cc
|
12q12
|
|
|
|
|
|
| TRIM |
Ro52, SSA1(human) |
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
11p15.5 |
|
Ro52 |
RNA,
Ro60, UnpEL |
TNFa,
IFNa/b,
IFNg, |
B, T |
|
RoRet, TRIM38, RNF15 (human) |
|
induce
|
|
RING/ZF(B)/cc/PRY/SPRY |
6p21.3 |
|
|
|
hemato.
|
|
|
RFP, TRIM27 (human) |
induce
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
6p22 |
|
|
DNA |
|
|
|
TRIM4 (human) |
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
7q22-q31.1 |
|
|
|
|
|
|
TRIM5 (human) |
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
11p15 |
|
TRIM5 |
|
|
|
|
TRIM15 (human) |
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
6p21 |
|
|
|
|
|
|
TRIM11, BIA1 (human) |
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
1q42.13 |
|
Humanin |
|
|
|
|
TRIM17, RNF16, TERF (human) |
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
1q42 |
|
|
|
|
|
|
TRIM41 (human) |
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
5q35.3 |
|
|
|
Brn3b |
|
|
TRIM23 (human) |
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
6p21.3 |
|
|
|
|
|
|
TRIM26, ZNF173 (human) |
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
6p21.3 |
|
|
|
MVA
|
|
|
TRIM35, MAIR
(human) |
induce |
|
|
RING/ZF(B)/cc/PRY/SPRY |
8p21.1 |
|
|
|
M-CSF |
|
|
Efp, ZNF147 (human) |
|
|
1 |
RING/ZF(B)/cc/PRY/SPRY |
17q23.1 |
|
14-3-3sigma |
|
estrogen, IFNa/b,
LPS,
HOX11
|
|
|
SS-56, Ro/SSA SS-56, FLJ10369, RNF137 (human) |
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
11pter-p15.5 |
|
|
|
|
|
|
TRIM22, STAF50 (human) |
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
11p15 |
|
|
|
IFNa/b,
HCV |
hemato.
|
|
TRIM14 (human) |
|
|
|
/ZF(B)/cc/PRY/SPRY |
9q22.33 |
|
|
|
HCV,
Lm |
hemato.
|
|
FLJ10759 (human) |
|
|
|
RING/ZF(B)/cc/PRY/SPRY |
1p35.1 |
|
|
|
|
|
|
TRIM2 (human) |
|
|
|
RING/ZF(B)/cc(BBC)/IG/NHLx6 |
4q31.23 |
|
|
|
|
brain
|
|
TRIM34, BERP, RNF21 (human) |
|
|
|
RING/ZF(B)/cc(BBC)/IG/NHLx6 |
11p15.5 |
|
|
|
IFN |
|
|
TRIM32 (human) |
|
|
|
RING/ZF(B)/cc(BBC)/IG/NHLx6 |
9q32-9q34.11 |
|
|
tat |
DAC/TSA,
A2aR |
|
|
TRIM3, BERP, HAC1, RNF22(human) |
|
|
|
RING/ZF(B)/cc(BBC)/IG/NHLx6 |
11p15.5 |
|
|
|
|
|
|
Midline 1, OSX, MID1, FXY, TRIM18 (human) |
|
|
|
RING/ZF(B)x2/cc(BBC)/FN3/PRY |
Xp22 |
|
|
|
|
|
|
Rbcc728, TRIM36 (human) |
|
|
|
RING/ZF(B)/cc(BBC)/FN3/PRY |
5p14.2-q22.3 |
|
|
|
|
|
|
TRIM46, FLJ23229 (human) |
|
|
|
RING/ZF(B)/cc(BBC)/FN3 |
1q21.2 |
|
|
|
|
|
|
TRIM9 (human) |
|
|
|
RING/ZF(B)x2/cc(BBC)/FN3/PRY/SPRY |
14q21.3 |
|
|
|
HNF4a
|
brain
|
|
TIF1, TRIM24 (human),
bonus, bon (Dm) |
|
|
|
RING/ZF(B)/cc(BBC)/PHD/BROMO |
7q32-q34 |
|
|
ER |
estrogen
|
|
|
KAP1, TIF1beta, TRIM28 (human,
mouse) |
|
|
|
RING/ZF(B)/cc(BBC)/PHD/BROMO |
19q13.4 |
|
|
ZFPs;( KOX1,
KRAZ1,
MZF13,
6D,
MZF22,
HZF4,KRAZ2,MTZ1,
HP1),
GR,
NF-IL6,
MM1,
SETDB1 |
|
|
|
TIF1gamma, TRIM33, PTC7, RFG7, TF1G, TIF1G, Ectodermin/Ecto (human) |
|
|
|
RING/ZF(B)/cc/PHD/BROMO |
1p13.1 |
|
SMAD4
|
|
|
|
|
RFPL1 (human) |
|
|
|
RING/PRY/SPRY |
22q12.3 |
|
|
|
|
|
|
RFPL2 (human) |
|
|
|
RING/PRY/SPRY |
22q12.3 |
|
|
|
|
|
|
RFPL3 (human) |
|
|
|
RING/PRY/SPRY |
22q12.3 |
|
|
|
|
|
|
HZFw1 (human) |
|
|
|
RING/PRY/SPRY |
6p21.3 |
|
|
|
|
|
|
RNF18 (human) |
|
|
|
RING/ZF(B)/SPRY |
11p11.12-q12 |
|
|
|
|
|
|
ASH2L, Ash2 (human,
Dm) |
|
|
dm |
RING(PHD)/SPRY |
8p11.2 |
|
|
|
CREB |
|
|
TRIM8, RNF27 (human) |
|
|
|
RING/ZF(B)/cc |
10q24.3 |
|
SOCS1 |
|
|
APCs, NK
|
|
TRIM31(human) |
|
|
|
RING/ZF(B)/cc |
6p21.3 |
|
|
|
|
|
|
LEU5, RFP2(human) |
|
induce
|
|
RING/ZF(B)/cc |
13q14.3 |
|
|
|
RA |
testis, oocyte
|
|
Nrdp1, FLRF, SBBI03 (human) |
|
|
|
RING/ZF(B)/cc/ErbB3AD |
12q12 |
|
ErbB3,
ErbB4, BRUCE |
UBP8
|
|
|
|
MuRF1, RNF28, SMRZ (human) |
|
|
1 |
RING/ZF(B)/cc(BBC) |
1p34-p33 |
|
|
titin,
SMT3b |
GMEB-1 |
heart, sk. muscle
|
|
MuRF-2, RNF29 (human) |
|
|
|
RING/ZF(B)/cc(BBC) |
8q13.1 |
|
|
|
|
|
|
MuRF-3, RNF30 (human) |
|
|
|
RING/ZF(B)/cc(BBC) |
2p23.2 |
|
|
|
|
|
|
TRIM52, RNF102, MGC16175 (human) |
|
|
|
RING/ZF(B) |
5q35.3 |
|
|
|
|
hemato.
|
|
TRIM48, RNF101, MGC4827 (human) |
|
|
|
RING/ZF(B) |
11q12.1 |
|
|
|
|
|
| Other ZF |
PML, TRIM19 (human,
mouse,
rat) |
mediate
|
|
L |
RING/ZFx2 |
15q22 |
1 |
|
eIF4E,
DAXX,
p53,
Rb,
HDAC |
p53,
BCR,
TNFa,
IFNa,
IFNb,
IFNg,
Ld,
SUMO,b-catenin, sentrins |
B, PML/RAR by t(15;17) |
| |
ZNF313 (human) |
|
|
|
RING/ZF x2 |
20q11.21-q11.23 |
|
|
|
|
|
|
RNF125, FLJ20456, TRAC1 (human) |
|
|
|
RING/ZF |
18q11.2 |
|
RNF125
|
|
|
B, T, NK
|
|
STRIN (human) |
|
|
|
RINGx2 |
18q11.2 |
|
|
|
|
hemato.
|
|
NF-X1, NFX1 (human) |
|
|
|
RING/ZFx9/R3H |
9p13.3 |
|
NF-X1 |
|
|
repressor of MHCII |
|
HSPC070, RNF62, makonin 2, MKRN2 (human) |
|
|
|
ZFx3/RING/ZF |
3p25 |
|
|
|
|
|
|
makorin, ZFP127, MKRN1 (human) |
|
|
|
ZFx2/RING/ZF |
15q11-q13 |
|
hTERT
|
|
|
|
| cc |
RAG1 (human) |
|
|
L |
?/cc/RING/? |
11p13 |
1 |
S-peptide,
RAG1 |
|
CD40 |
thy
|
|
RAG2 (human) |
|
|
L |
?/PHD(RING)/? |
11p13 |
|
|
|
CD40,
Subst.P |
|
|
RBP95, Staring, RNF40 (human) |
|
|
|
cc x6/RING |
16p11.2-p11.1 |
|
Syntaxin
1 |
Rb,
UbcH8 |
|
|
|
RNF20 (human) |
|
|
|
cc x6/RING |
9q22 |
|
|
|
|
|
|
RNF123, FLJ12565 (human) |
|
|
|
?/cc/RING |
3p24.3 |
|
|
|
|
|
|
DZIP3, hRUL138, KIAA0675 (human) |
|
|
|
ccx2/RING |
3p13-q13.2 |
|
|
HBV
RNA |
|
|
|
MAT1, MNAT1 (human,
mouse,
rat,
Xl) |
|
|
1 |
RING/cc |
14q23 |
|
|
|
cyclin
H, CDK7,
TFIIH,
Oct1,
Oct2,
Oct3,
MTA1 |
|
|
FLJ35794 (human) |
|
|
|
RING/cc |
3q29 |
|
|
|
|
|
| RCC1 |
MYCBP2, KIAA0916 (human) |
|
|
|
RCC1/ZF(B)/RING |
13q22 |
|
|
Myc
|
|
B, T, NK, brain
|
| TUDOR |
PHF1 (human) |
|
|
|
TUDOR/RING(PHD)x2 |
6p21.3 |
|
|
|
|
B, T, NK, oocyte
|
| Rad18 |
Rad18 (human) |
|
|
|
RING/ZnF(Rad18)/SAP |
3p25-p24 |
|
PCNA |
Rad6 |
|
|
KIAA1972
|
KIAA1972 (human)
|
|
|
|
?/SPRY/RING
|
16q13
|
|
|
|
|
|