Index Caspase CARD/DED/BIR Bcl-2  DD TNF/TNFR Kinases ILs Viral Lipid Engulf TF RING Toll Other Apop Other NFkB Alphabet

E3-related proteins
 

RING proteins and their-related proteins
Subgroup Protein Name
Apoptosis
NFkB activation
 KO Structure Locus 3D substrates (other or undefined) binding partners upstream regulators memo
BRCA1 & BRCT






 BRCA1(human, mouse, rat)
induce
L RING/?/BRCTx2
L BRCA1, H2A, H2AX, H2B, H3, H4, B23 UBC4, UbcH5a, UBCH5c, ATF1, BAP1, BRAP, BARD1, CBP, CtIP, Elk-1, KPNA1, Lyn, p53, RAD50, 53BP1, IFI16, BRIP1, ZBRK1 CREB,c-Myc, E2F6, GABPs, Id4, BRCA1, FANCD2, nicotine, irrrad, methylation bm, gene targets
BARD1(human)
induce/ inhibit

RING/ANKx3/BRCTx2 2q34-q35 w/BRCA1
BRCA1, p53 stress bm, calpain
53BP1, TP53BP1 (human, mouse, Xenopus)
mediate

?/BRCTx2 15q15-q21 w/p53
p53, BRCA1 ATM, DNA damage,
MDC1, NFBD1 (human)
mediate

FHA/BRCT 6pter-p21.31

CHK2 MeDNA bm, preB
FLJ12847 (human, Dm)


BRCTx2 8p23.1

Rho
NK, B
TOPBP1(human), MUS101(Dm)


BRCTx7 3q22.2

TopII, E2F1
bm, B, T, NK
ECT2 (human)
induce
BRCTx2/RhoGEF/PH
 3q26.1-q26.2




F37D6.1(Ce)


BRCTx5





At1g04020(At)


RING/PHD/BRCTx2





CBL

 CBL(human, mouse, chicken, Dm, Ce)
inhibit
L SH2(Y-P BD)/RING/ZF/UBA 11q23.3 w/Ubch7 PDGFRa, ErbB1, Syk, Lck,  Lyn, Fyn, RON, c-Kit, TCRzeta, PI3Kp85, Hck, c-Met, EGFR, Flk1, EphA2, Notch1, Vav, p75NTR
 Ubch7, APC, SPRY2, CIN85, CMS cisplatin, UVA, HECTs
CBL-B(human)

L CBL-N/SH2/RING 3q13.11
PI3Kp85, EGFR, Kit, PDGFR, C3G CIN85 FKHRL1 CD28
CBL-C, CBL3 (human)

1 CBL-N/RING 19q13.2
EGFR AIP4, WWP1
epithelium
IAPs see BIR proteins
MDM2
 Mdm2 (human(hdm2), mouse, Xenopus)
inhibit
L
 MDM2/ZF/RING 12q14.3-q15 L p53, p73, AR, mdm2, mdmX, Numb, Tip60 p19ARF, mdm4, p75a, TAFII250, HDAC1 p53, BRCA1, c-Myc, O stress, NO, irrad., bFGF, IGF-I, IGF-II, Lm, UV, SUMO-1, Ubc9; p38, Akt,  PLD, HIPK1, VSV, estrogen
Mdm4/mdmX(human, mouse)
promote
1
1q32
p53, mdmX
N-Myc, ARNT2
TRAF TRAFs, TRAF-related proteins (including TRIM37), see "other NF-kB regulators"
TRIP see "other NF-kB regulators"
MEKK1 see kinases
Siah-1 Siah-1(human), Sina (Dm) 
promote
L RING/ZFx2/TRAF-C-like 16q12 1 rpvaxVxPxxr, b-catenin, Kid, DCC, BAG1, Myb, N-CoR, synphilin-1, CtIP, Numb, Tramtrack BAG-1, mGluR,Ubc9, UbcH5, PHYL,  Vav, a-tublin,  SIP, polycystin-1, PEG10, Phyllopod, Ebi p53, insulin, disabled1, LPS Ras-dep.

Siah-2(human)
promote
L RING/TRAF-C-like 3q25
TRAF2 Vav,

Multi-RING parkin, Park2 (human, mouse)
supress

UBQ/RING/(IBR)/RING/(IBR) 6q25.2-q27 L CDCrel-1, a-synuclein, synphilin-1, aminoacyl-tRNA synthetase UbcH7, UbcH8,  CHIP, Hsp70, Rpn10
 FLRF casp, leprosy suscept.

ariadne, UBCH7BP, HHARI, ARIH1, UIP77 (human, Dm)

Dm ?/RING/(IBR)/RING/(IBR)/? 15q24
4EHP UbcH7, UbcH8, UbcM4


TRIAD1, ARIH2, ariadne-2, UIP48 (human, mouse)


?/RING/(IBR)/RING/(IBR)/RING/(IBR)/? 3p21.2-p21.3

UbcM4 hypoxia, Blimp1

ARA54, HFB30, RNF14 (human)


RWD/RING/(IBR)/RING/(IBR) 5q23.3-q31.1

AR


KIAA0161 (human)


RING/(IBR)/RING/(IBR)/RING 2p25.3





RNF144 (human, mouse)


RING/(IBR)/RING 2p25.2





dorfin, RNF19  (human) inhibit?

RING/(IBR)/RING/(IBR)/TMx2? 8q22
synphilin-1 Sp1 AdV, Ret

C20orf18 (human)


UBQ/ZF/RING 20p13





XAP3, UIP28, HOIL-1, RBCK1, C20orf18 (human)


UBQ/ZF/RING/(IBR)/RING/(IBR) 20p13
ox.IRP2 UbcM4, HBV-X, PKCbI


TRIAD3, UIP83, ZIN (human)


RING/(IBR)/RING/(IBR) 7p22.2
TLRs
 		RIP


ZIBRA, RNF31 (human)


RING/(IBR)/RING 14q11.2





p53RFP, IBRDC2 (human, mouse, zebrafish)


RING/(IBR)/RING 6p22.3


p53
PDZ
 LNX(human, mouse)


RING/PDZx4 4q11
Numb


LNX2, MGC46315 (human)


RING/PDZx4 13q12.13




PDZRN3 (human)


RING/PDZx2/cc 3p14.1




LNX4, PDZRN4 (human)


RING/PDZx2/cc
 12q12




TRIM Ro52, SSA1(human)


RING/ZF(B)/cc/PRY/SPRY 11p15.5
Ro52 RNA, Ro60, UnpEL TNFa, IFNa/b, IFNg, B, T

RoRet, TRIM38, RNF15 (human)
induce
RING/ZF(B)/cc/PRY/SPRY 6p21.3


hemato.

RFP, TRIM27 (human)
induce

RING/ZF(B)/cc/PRY/SPRY 6p22

DNA


TRIM4 (human)


RING/ZF(B)/cc/PRY/SPRY 7q22-q31.1





TRIM5 (human)


RING/ZF(B)/cc/PRY/SPRY 11p15
TRIM5



TRIM15 (human)


RING/ZF(B)/cc/PRY/SPRY 6p21





TRIM11, BIA1 (human)


RING/ZF(B)/cc/PRY/SPRY 1q42.13
Humanin



TRIM17, RNF16, TERF (human)


RING/ZF(B)/cc/PRY/SPRY 1q42





TRIM41 (human)


RING/ZF(B)/cc/PRY/SPRY 5q35.3


Brn3b

TRIM23 (human)


RING/ZF(B)/cc/PRY/SPRY 6p21.3





TRIM26, ZNF173 (human)


RING/ZF(B)/cc/PRY/SPRY 6p21.3


MVA

TRIM35, MAIR (human) induce

RING/ZF(B)/cc/PRY/SPRY 8p21.1


M-CSF

Efp,  ZNF147 (human)

1 RING/ZF(B)/cc/PRY/SPRY 17q23.1
14-3-3sigma
estrogen, IFNa/b, LPS, HOX11

SS-56,  Ro/SSA SS-56, FLJ10369, RNF137 (human)


RING/ZF(B)/cc/PRY/SPRY 11pter-p15.5





TRIM22, STAF50 (human)


RING/ZF(B)/cc/PRY/SPRY 11p15


IFNa/b, HCV hemato.

TRIM14 (human)


/ZF(B)/cc/PRY/SPRY 9q22.33


HCV, Lm hemato.

FLJ10759 (human)


RING/ZF(B)/cc/PRY/SPRY 1p35.1





TRIM2 (human)


RING/ZF(B)/cc(BBC)/IG/NHLx6 4q31.23



brain

TRIM34, BERP, RNF21 (human)


RING/ZF(B)/cc(BBC)/IG/NHLx6 11p15.5


IFN

TRIM32 (human)


RING/ZF(B)/cc(BBC)/IG/NHLx6 9q32-9q34.11

tat DAC/TSA, A2aR

TRIM3, BERP, HAC1, RNF22(human)


RING/ZF(B)/cc(BBC)/IG/NHLx6 11p15.5





Midline 1, OSX, MID1, FXY, TRIM18 (human)


RING/ZF(B)x2/cc(BBC)/FN3/PRY Xp22





Rbcc728, TRIM36 (human)


RING/ZF(B)/cc(BBC)/FN3/PRY 5p14.2-q22.3





TRIM46, FLJ23229 (human)


RING/ZF(B)/cc(BBC)/FN3 1q21.2





TRIM9 (human)


RING/ZF(B)x2/cc(BBC)/FN3/PRY/SPRY 14q21.3


HNF4a brain

TIF1, TRIM24 (human), bonus, bon (Dm)


RING/ZF(B)/cc(BBC)/PHD/BROMO 7q32-q34

ER estrogen

KAP1, TIF1beta, TRIM28 (human, mouse)


RING/ZF(B)/cc(BBC)/PHD/BROMO 19q13.4

ZFPs;( KOX1, KRAZ1, MZF13, 6D, MZF22, HZF4,KRAZ2,MTZ1, HP1), GR, NF-IL6, MM1, SETDB1


TIF1gamma, TRIM33, PTC7, RFG7, TF1G, TIF1G, Ectodermin/Ecto (human)


RING/ZF(B)/cc/PHD/BROMO 1p13.1
SMAD4



RFPL1 (human)


RING/PRY/SPRY 22q12.3





RFPL2 (human)


RING/PRY/SPRY 22q12.3





RFPL3 (human)


RING/PRY/SPRY 22q12.3





HZFw1 (human)


RING/PRY/SPRY 6p21.3





RNF18 (human)


RING/ZF(B)/SPRY 11p11.12-q12





ASH2L, Ash2 (human, Dm)

dm RING(PHD)/SPRY 8p11.2


CREB

TRIM8, RNF27 (human)


RING/ZF(B)/cc 10q24.3
SOCS1

APCs, NK

TRIM31(human)


RING/ZF(B)/cc 6p21.3





LEU5, RFP2(human)
induce
RING/ZF(B)/cc 13q14.3


RA testis, oocyte

Nrdp1, FLRF, SBBI03 (human)


RING/ZF(B)/cc/ErbB3AD 12q12
ErbB3, ErbB4, BRUCE UBP8


MuRF1,  RNF28,  SMRZ (human)

1 RING/ZF(B)/cc(BBC) 1p34-p33

titin, SMT3b GMEB-1 heart, sk. muscle

MuRF-2,  RNF29 (human)


RING/ZF(B)/cc(BBC) 8q13.1





MuRF-3,  RNF30 (human)


RING/ZF(B)/cc(BBC) 2p23.2





TRIM52, RNF102, MGC16175 (human)


RING/ZF(B) 5q35.3



hemato.

TRIM48, RNF101, MGC4827 (human)


RING/ZF(B) 11q12.1




Other ZF PML, TRIM19 (human, mouse, rat)
mediate
L RING/ZFx2 15q22 1
eIF4E, DAXX, p53, Rb, HDAC p53, BCR,  TNFa, IFNa, IFNb, IFNg, Ld, SUMO,b-catenin, sentrins B, PML/RAR by t(15;17)
  ZNF313 (human)


RING/ZF x2 20q11.21-q11.23





RNF125, FLJ20456, TRAC1 (human)


RING/ZF 18q11.2
RNF125

B, T, NK

STRIN (human)


RINGx2 18q11.2



hemato.

NF-X1, NFX1 (human)


RING/ZFx9/R3H 9p13.3
NF-X1

repressor of MHCII

HSPC070, RNF62,  makonin 2, MKRN2 (human)


ZFx3/RING/ZF 3p25





makorin, ZFP127, MKRN1 (human)


ZFx2/RING/ZF 15q11-q13
hTERT


cc RAG1 (human)

L ?/cc/RING/? 11p13 1 S-peptide, RAG1
CD40 thy

RAG2 (human)

L ?/PHD(RING)/? 11p13


CD40, Subst.P

RBP95, Staring, RNF40 (human)


cc x6/RING 16p11.2-p11.1
Syntaxin 1 Rb, UbcH8


RNF20 (human)


cc x6/RING 9q22





RNF123, FLJ12565 (human)


?/cc/RING 3p24.3





DZIP3, hRUL138, KIAA0675 (human)


ccx2/RING 3p13-q13.2

HBV RNA


MAT1, MNAT1 (human, mouse, rat, Xl)

1 RING/cc 14q23


cyclin H, CDK7, TFIIH, Oct1, Oct2, Oct3, MTA1

FLJ35794 (human)


RING/cc 3q29




RCC1 MYCBP2, KIAA0916 (human)


RCC1/ZF(B)/RING 13q22

Myc
B, T, NK, brain
TUDOR PHF1 (human)


TUDOR/RING(PHD)x2 6p21.3



B, T, NK, oocyte
Rad18 Rad18 (human)


RING/ZnF(Rad18)/SAP 3p25-p24
PCNA Rad6

KIAA1972
 KIAA1972 (human)


?/SPRY/RING
 16q13




Subgroup Protein Name Apoptosis NF-kB KO Strucuture Locus 3D Substrate (other or undefined) binding partners upstream regulators Memo
FHA Chfr (human, mouse)

1
 FHA/cc/RING 12q24.33 1 (P-Thr); Chfr, Plk1 Aurora A
 methylation T, NK, myeloid

RNF8 (human, mouse, rat, Xl, zebrafish)


FHA/cc/RING 6p21.3

ActA, RXRa
oocyte
MIR MIR, MYLIP (human)


FERM/RING 6p23-p22.3
CD86 myosin L
B, prostate
Hakai Hakai (human)


RING/PHD 7q22.2
E-cadherin

endothelial, endocytosis
DRP DRP1, DMDL, Uterophin (human)


CHx2/SPECx>19/WW/ZF(zz)/cc 6q24




RRM CNOT4 (human, Sc)


RING/cc/RRM/ZF-CCCH 7q22-qter





BRAP (human)


RRM/RING/ZF/cc 12q24

NLS

FYVE  RBQ1, RBBP6 (human)


FYVE/RING/cc 16p12-p11.2

Rb
hemato

FRING, Sakura, CARP2 (human, mouse)


FYVE/RING 17q11.2
FRING



RIFF, RNF34, Momo, CARP1 (human, mouse, rat) inhibit

FYVE/RING 12q24.31
RIFF
casp8, casp10


IQ RNF32 (human)


RING/IQ/RING 7q35-q36




C-WD40 COP1 (human) inhibit

RING/cc/WD40x6 1q24.1
c-Jun, p53

hemato.
  RFWD1, TRAF7 (human)
induce
 activate
RING x2/cc/WD40 x7 16p13.11
RFWD1 MEKK3, RFWD1


DKFZp434F054 (human)


RING/WD40x6 16p13.3



preB
TPR RNF127, FLJ22612 (human)


TPRx2/RING/LON Xq24





TTC3 (human)


TRPx4/cc/RING 21q22.2



brain

rapsyn, RAPSN (human)

1 TRPx6/RING 11p11.2-p11.1




N-WD40R VPS11 (human)


WD40x4/CLH(LH2)/cc/RING 11q23

syntaxin 7

UBQ URF2, NIRF, ICBP90, NP97 (human)


UBQ/PHD(RING)/SRA 9p24.1-p23

PCNP

SAND AIRE (human, mouse)

1 Sp100/SAND/PHD(RING)x2 21q22.3


LT targets
Tal
 Tal, LRSAM1 (human)


LRRx4/ERM/CC/SAM/RING
 9q34.13
TSG101


Memb.  PEX10, peroxin 10 (human, mosue, rat)


?/TM/RING 1p36.11-1p36.33

PEX5, PEX10


RNF13, RZF (human)


PA/TM/RING 3q24


IL5, IFNa, insulin, IGF-II, ALA

DKFZP566H073 (human)


PA/TM/RING 17p13.3





GREUL1, GRAIL, FLJ23516  (human, mouse)


PA/TM/RING Xq22.2


Stat4

RNF133, LOC168433 (human)


PA/TM/RING 7q22.1





RNF149, LOC284996 (human)


PA/TM/RING 2q12.1





IBRDC1 (human)


IBRx2/TM 6q22.33





BAR, BFAR, RNF47 (human)
inhibit

RING/TM/SAM/TMx2 16p13.13-16p12.3

Bcl-2, Bcl-xL, Caspase-8, Caspase-9
oocyte

ZNF179 (human)


RING/GBP/TMx2 17p11.2



brain

IBRDC3, FLJ90005 (human)


IBRx2/TMx2 1p34.3



PBL

ZFP103, kf-1(human)


?/TMx3/RING 2p11.2
KF-1



RNF26 (human)


TMx3/RING 11q23





ZFP103 (human)


TMx3/RING 2p11.2





TRC8, RNF139 (human)

d TMx13/RING 8q24
TRC8, JAB1, VHL



FLJ12875 (human, At, Dm)
induce
?/TM/RING 1p36.13





FLJ20225 (human)


RING/TMx2 1p36.13





KIAA1399 (human)


RING/TMx2 2q35


RANTES

G1RP, goliath, RNF130 (human)


TM/RING/(TM) 5q35


IL3 APCs

AMFR (human)


TMx5/RING/CUE 16q21


AMF

LOC285533 (human)


TMx5/RING 4q31.3



brain

HRD1, Synoviolin (human, mouse)
inhibit
1 TMx5/RING 11q12
ER proteins
ER stress, IRE1, ATF6, c-Myb

FLJ31951 (human)


TMx12/RING 5q34




Np95 Np95, ICBP90, UHRF1, RNF106 (human)
inhibit
1 Ub/RING/SRA/RING 19p13.3
H3
E1A Thy, bm, oocyte
neuralized neuralized/ neu, NEURL, RNF67 (human, Xl, Dm)


NEUZ x2/RING 10q25.1
Delta

Notch
helicase HIP116, HLTF, SNF2L3, SMARCA3 (human)


helicase/RING/helicase C 3q25.1-q26.1

Sp1, Sp3


ATRX (human)


RING/cc/DEXD/helicase C Xq13.1-q21.1

Daxx
hemato.
KH Tino, RKHD1 (human partial, rat)


KHx2/RING 19p13.3


Bcl-2 mRNA

LOC51320 (human)


KHx2/RING 18q21.1



hemato.
Mib
 DIP1, Mib, Mib1 (human, zebrafish, Dm)
promote/inhibit

HERC2/ZnF/HERC2/Mibx2/Ank/RINGx2/cc/RING 18q11.2
Delta, DIP1, DAPK



MIB2 (human)



1p36.33
Delta


novelzin skeletrophin, novelzin, LOC142678 (human)
induce
ZnF/Ankx9/RINGx2
 1p36.32




SH3 SH3RF2, FLJ23654, RNF158 (human)


RING/SH3x3 5q31.3-q32





POSH, RNF142, SH3RF1, SH3MD2 (human)


RING/SH3x6 4q32.3
Rac


deltex DTX1 (human)


WWEx2/RING/DTXc 12q24.11

Notch, GRB2, p300 RANKL B

DTX2 (human)


WWEx2/RING/DTXc 7p12.3





DTX3 (human)


cc/RING/DTXc 12q13.2





DTX4, KIAA0937 (human)


WWEx2/RING/DTXc 11q12.3





rhysin 2, BBAP, LOC151636 (human)


RING/DTXc 3q21.1 BBAP
BAL, DTX1
hemato.

dactylidin, RNF146, DKFZp434O1427 (human)


RING/WWE 6q22.1-q22.33




RWD


 RNF25, AO7(human, mouse)
enhance
RWD/RING 2q35
AO7 p65
hemato.
RNF6 (human)


RWD/RING 13q12.2


Blimp1
NY-REN-43, R-LIM, RNF12 (human)


RWD/RING Xq13-q21 Ldb1

estrogen
FLJ12270 (human)


WD40/RWD/ZnF(BED)/RING 16q22.2



hemato
BMI




 BMI1 (human)
inhibit
1 RING/BMI-C 10p13


nicotine, Stat4 transcription repression
RNF3, DONG1(human)


RING/BMI-C 4p16.3


estrogen, b-catenin
Mel-18, ZNF144 (human)


RING/BMI-C 17q12




RNF110 (human)


RING/BMI-C 10q23.33




MBLR, RNF134 (human)


cc/RING/BMI-C 19p13.11

RING1, 

NSPC1, MGC10882  (human)


RING/BMI-C
 2p13.1



hemato.
RNF159, MGC16202 (human, mouse)


RING/BMI-C 10q23.33



erythroid
NSPc1 (human)


RING/BMI-C 2p12



hemato.
RNF110, ZNF144 (human)


RING/BMI-C 17q12




UBR1
 UBR1 (human)

L
 ZnF(UBR1)/RING
 15q13

RECQL4
N-end rule pathway, hemato.
UBR2, C6orf133 (human)

1
6p21.1




KIAA2024 (human)


cc/RING/ZnF(NFX)
 2q31.1




Other CGR19, CGRRF1 (human, At, Dm)


?/RING 14q22.1


p53

Pirh2, CHIMP, ARNIP, RCHY1 (human, mouse)


?/RING 4q21.1 p53
PLAG1, AR p53, irrad.

ZNF294, C21orf10 (human)


?/RING 21q22.11





TOPORS, LUN, TP53BPL (human)


?/RING/?
 9p21
p53 TopoI, DNA, AAV2Rep78/68


ZNRF2, LOC223082 (human)  

NIN283/ZnF/RING 7p15.1



DC (human)

NIN283, Zrfp1, ZNRF1  (human, mouse)


NIN283/ZnF/RING 16q23.1



fetal brain

RNF44, KIAA1100 (human)


KIAA1100-N/RING 5q35



hemato.

RNF38 (human)


KIAA1100-N/RING 9p13-p12





FLJ20315 (human)


FLJ20315-N/RING/? 17pter-p13.1





FLJ12747 (human)


FLJ20315-N/RING/? 22q12.1





Mahoganoid, mahogunin, GP2B, CD41B, ITGA2B, RNF156, KIAA0544, MGRN1 (human, mouse, rat, Dm)

md KIAA0544/RING 16p13.13



hair color

RNF157, KIAA1917 (human)


KIAA0544/RING 17q25.3





Praja1, PJA1, FLJ11830(human)


Praja-N/RING Xq12
Praja1, Dlxin-1 UbcH5B


PJA2, NEURODAP1, KIAA0438 (human)


Praja-N/RING 5q21.3

UbcH5B


RNF126, FLJ20552 (human)


RNF126-N/RING 19p13.3



hemato.

ZNF364 (human)


RNF126-N/RING 1q21.1



erythroid

RNF1, RING1 (human)


RING/RNF1-C 6p21.3


SCF

RNF2, DING, BAP-1(human)


RING/RNF1-C 1p36.13-q31.3

Hip-2, S6'



CCNB1IP1, HEI10 (human)


RING/? 14q11.1
cyclins B1, E2

hemato., epithelial
Subgroup Protein Name Apoptosis NF-kB KO Strucuture Locus 3D Substrate (other or undefined) binding partners upstream regulators Memo
small ZFP26, RNF141 (human, mouse)


?/RING 11pter-p15.4





RNF4 (human)


RING 4p16.3



hemato.

RNF5, Rma1 (human)


RING 6p21.3
Paxillin



ROC1 (human)
mediate
RING 22q13.2
Skp2, p27CDKI, IkBa,E2F1, cyclin D1, Sic1, Cln1/2, p53, Smad3 cullins, CAND1, Skp1, Skp2, UBC5c, NEDD8
SCF E3

ROC2, SAG, RNF7 (human) protect

RING 3q22-q24

cullin-4A


Rbx1 (human)


RING 22q13.2 w/Skp1+2/Cul1 HIF1a, Vav Skp1, Skp2, Cul1 VEGF VCB-CUL2 E3

APC11, ANAPC11 (human)


RING 17q25.3
cyclins, Pds1,
H2O2

RNF11 (human)


PY/RING 1pter-p22.1
Smurf2, RNF11, Smad2, Smad3, p73,  Smurf2, AIP4; Akt
 CIITA, Blimp1

RNF24 (human)


RING 20p13-p12.1





FLJ23360(human)


RING 16p13.3





LOC51255 (human)


RING 2p24.3-p24.1





RNF111, arkadia, ARK (human)


RING 15q21





RNF122, FLJ12526 (human)


RING 8p11.23





RNF121, FLJ11099 (human)


RING 11cen-q12.1





RNF135, MGC13061 (human)


RING 17q11.2





DKFZp761H1710(human)


RING *




Viral ICP0, Vmw110 (HSV11, HSVEB, HSV2H)


RING/?

DNA-PK, ICP0, Pml, Sp100, Cdc34

MIZ (RING-like domain) PIAS1 (human)


SAP/MIZ 15q22
STAT1(-), p53, Sp3, FAK, Axin SUMO1, UBC9, CSRP2, Gu, AR, DNA Sp1, Sp2, Sp3 hemato., SUMO ligase

PIAS3 (human)
inhibit

1q21
TCF4, C/EBPa, Axin, c-Myb MITF, Smad3, Smad4, Smad7, p65


MIZ1, PIASx (human)
(protect)
1 SAP/MIZ 18q21.1
STAT1, Axin IRF8 UVB

PIASy (human)



19p13.3





RAI17, hZimp10 (human)


MIZ 10q23.1

RA

F box/SOCS box - SCF related
Box family name species locus apoptosis KO structure 3D targets binding partners regulators expression
 memo
F LRR_CC Skp2, p45 human 5p13
L F/LRRCC 1 (P-Ser): p27Kip1, cyclin E, Myc
RA, estrogen ubiquitous


FBL2, FBXL2 human 3p22.2






brain


FBL3A human 13q22






ubiquitous


FBL4, FBXL4 human 6q16.1-q16.3






ubiquitous


FBL5, FBXL5 human 4p15.33






APCs


FBL6, FBXL6 human 8q24.3






ubiquitous


FBL7, FBXL7 human 5p15.1






ubiquitous


FBL8, FBXL9 human 16q22.1






ubiquitous


FBL11, FBXL11 human 11q12.2






ubiquitous


FBXL12, FLJ20188 human 19p13.2






thymus


FBXO37, MGC11279 human 10q24.32






ubiquitous


MGC15482, FBL2
human 17q12

F/LRRCC



ubiquitous


PRAME, OIP4 human 22q11.22

F/LRRCC

Opa IFNa ubiquitous

SPRY
 FSN1, LOC200933
 human, mouse, rat, Xl, zebrafish, fugu, Dm, Ce


F/SPRY
Alk?
 Rpm1, Skp1, Cullin
ubiquitous
 presynaptic differentiation

ARC FBX4, FBXO4 human 5p12

F/ARF

Skp1
ubiquitous

Nucleoplasmin FBX3 human 11p12

F/Nucleoplasmin



ubiquitous


Cyclin cyclin F, CCNF, FBX1, FBXO1
 human 16p13.3

F/Cyclin x2



erhyloid, preB, bone marrow

DSL LOC51725 human 3q21.1

ZF/DSL/F



sk. muscle, heart

RRC FBX7, FBXO7 human 22q12-q13

UBQ/F



erhyloid


FBX24, FBXO24 human 7q22

F/RRC



testis

TRP FBXO9 human 6p12.3-p11.2

TRP/F


Ct, irrad erhyloid

WD40 dactylin, SHSF3 human 10q24
1 F/WD40



ubiquitous



beta-TrCP, E3RSIkB, FWD1, BTRC, BTRCP, FBW1A, Slimb human, mouse, X.laevis, Dm 10q24-q25
1 F/WD40(x7)
P-Ser: IkBa,b,g, b-catenin, CD4(/w Vpu), Period, Timeless
Wnt-3A ubiquitous



betaTrCP2, BTRC2, FBW1B, FBXW1B human 5q35.1

F/WD40
P-Ser: IkBa

ubiquitous



C17ORF1 human 17p12

F/WD40



ubiquitous



FBXW2 human 9q34

F/WD40



ubiquitous



FBXW3 human 22q11

F/WD40



ubiquitous



CDC4, AGO, SCFFbw7, FBW7, FBXW7 human 4q31.23
inhibit
 1 F/WD40
Cycline E, p-c-Jun
estrogen brain, B, T, NK

unknown FBG2, Fbx6, FBXO6
 human 1p36.23-p36.11

F/?
cytosolic glycoprotein





FBX2, NFB42, FBXO2 human 1p36.21

F/FBA
cytosolic glycoprotein, UL9
 Skp1, Cullin1, Roc1
brain, spinal cord


FBX30, FBG3 human 1p36.21

F/?



ubiquitous (highest in brain)


FBG4, FBXO26
 human 19q13.2

F/?



ubiquitous


FBX21, FBXO21 human 12q24.21

F/?



ubiquitous


Fbx22 human 15q24.1

F/?



ubiquitous


Fbx25 human 8p23.3






ubiquitous


MoKA, FLJ13962 human 5q33.1

F/?


KLF7
 ubiquitous


FBXO32, atrogin-1
 human 8q24.13

F/?


AdV, FOXOs ubiquitous


FBXO30 human 6q24

?/F







FBXO34, FLJ20725 human 14q22.1

?/F



erythroid


FBH1, FBXO18 human 10p15.1

F/helicase

Skp1
ubiquitous


Tome-1, GRCC8 human, mouse,rat, 12p13




Skp1
preB, bone marrow


morgue Dm
mediate
F/UBCc
DIAP1



SOCS Socs Socs1, CIS1, JAB, SSI1 human, mouse 16p13.13 inhibit/promote L SH2/SOCS
JAKs, IRS1,2, IR EloginB/C, IRAK,TRIM8, Tec
 EWS/FLI-1, Egr1, Pim, TNFa, RANKL, IL2, IL4, IL6, IL7, IL9, IL10, IL13, IL15, LIF, EPO, IFNa, IFNb, IFNg, CT1, CNTF, G-CSF, GH,  PRL, TSH, insulin, SCF, LPS, CD8/28, PMA, STAT6, PPARg1, JunD, TRIF ubiquitous suppressor of cytokine signalling-1

(P-Tyr) Socs2, CIS2, SSI-2 human, mouse, chick 12q
L SH2/SOCS
JAKs, IRS1,2
AIRE, IL2, IL6, IFNa, CD3, GH, PRL, insulin, CNTF, GR, ribavirin ubiquitous STAT induced STAT inhibitor-2


Socs3, CIS3, SSI-3 human, mouse 17q25.3
L SH2/SOCS
JAKs
NF-kB, STAT1, STAT3 (-), TNFa, RANKL, IL1, IL2, IL3, IL6, IL9, IL10, IL11, IL22, LIF, IFNg, OSM, EPO, TPO, G-CSF, CT1, CNTF, leptin, GH, PRL, TSH, EGP, insulin, IGF-II, PDGF, BFGF,TGFb, endostatin, TIMP1,  fumagillin, PS, LTA, Bm, Ld, Lm, LLO, Mt, Tg, HHV8, EV71, Tprim, YopP, PGF2a, IKKs, TRIF ubiquitous cytokine-inducible SH2-containing protein 3


Socs4, CIS4, SSI4, (SOCS7)
 human, mouse 14q22.2

SH2/SOCS



ubiquitous


Socs5, CIS6 human, mouse 2p21
1
 SH2/SOCS


IL4R ubiquitous


Socs6 human, mouse 18q22.2
1 SH2/SOCS
IR
IRS4 ubiquitous


Socs7, NAP4, Nck
 human, mouse 17q21.1

SH2/SOCS



testis

ASB ASB1 human 2q37

Ank/SOCS



ubiquitous


ASB2 human 14q31-q32

Ank/SOCS



sk. muscle, heart


ASB3 human 2p16-p14

Ank/SOCS


CREB ubiquitous


ASB4 human 7q21-q22

Ank/SOCS



ubiquitous


ASB5 human 4q34.1

Ank/SOCS



ubiquitous


ASB6 human, mouse 9q34.13

Ank/SOCS



ubiquitous


ASB7 human, mouse 15q26.3

Ank/SOCS



ubiquitous


ASB8 human, mouse 12q13.12

Ank/SOCS



ubiquitous


ASB9 human, mouse Xp21.3

Ank/SOCS



ubiquitous


ASB10 human 7q35

Ank/SOCS



ubiquitous


ASB11 human Xp22.31

Ank/SOCS



ubiquitous


ASB12 human Xq11.1

Ank/SOCS



ubiquitous


ASB13 human 10p15.1

Ank/SOCS



ubiquitous


ASB14 human 3p21.1

Ank/SOCS



ubiquitous


ASB15 human 7q31.31

Ank/SOCS



ubiquitous


ASB16 human 17q21.31

Ank/SOCS



ubiquitous


ASB17 human 1p22.3

Ank/SOCS



ubiquitous


ASB18 human 17q21.31

Ank/SOCS



ubiquitous

NEUZ Ozz, NEURL2
 human, mouse, rat, Dm 20q13.12

NEUZ/SOCS
b-catenin

thymus

Elongin A Elongin A, TCEB3 human 1p36.1

TFS2N/SOCS



ubiquitous


Elongin A2, TCEB3L human 18q21.1

TFS2N/SOCS



ubiquitous


Elongin A3, TCEB3L2 human 18q12.3

TFS2N/SOCS



ubiquitous

MUF-1 MUF1 human 1p34.1

SOCS/LRR



ubiquitous

RAR Rar, SEC4L, RAB40B human 17q25.3

Rab/SOCS



brain, spinal cord


RAR2A, RAB40A human Xq22.1

Rab/SOCS



ubiquitous


RARL human 16p13.3

Rab/SOCS



ubiquitous

SSB SSB1, FLJ22393 human 1p36.22

Rab/SOCS



ubiquitous


SSB2, Grcc9 human 12p13.32

Rab/SOCS



ubiquitous


SSB3 human 16p13.11

Rab/SOCS



ubiquitous


SSB4 human 3q24

Rab/SOCS



ubiquitous

Tubby-like TULP1 human 6p21.3
1 Tubby



ubiquitous


TULP2 human 19q13.1






testis


TULP3 human 12p13
1




ubiquitous

VHL (Pro-OH)
human, mouse 3p26-p25
1 VHL
 1 HIF1a Cul2, EloginB/C, TRC8, Jade-1, TRC8 c-Myc, AP1 ubiquitous Von Hippel-Lindau syndrome

WSB WSB1 human 17q11.1

WD40/SOCS


KF1B ubiquitous


WSB2 human 12q24.23

WD40/SOCS



brain, spinal cord

E2, ROCK<CUL1<Skp1<Skp2(F)<Kip(P-Ser)
 
 
 

HECT proteins under construction
family name species locus apoptosis KO structure 3D targets binding partner regulators expression
 memo
WW (binds to PPXY motifi) NEDD4 human 15q

C2/WWx4/HECT 1 ENaC, N4BP1, N4BP2, N4BP3, N4WBP5, IGF1R, Cbl Plic2, annexin XIII, Grb10, UBC4, UbcH5B, UbcH5C, UbcH6, UbcH7, NDFIP1
 Sgk ubiquitous

RSP5, NEDD4L,  Nedd4-2 human 18q21

C2/WWx4/HECT
ENaC, RNA polII, Lyn, Syk LMP2A, UbcH6, UbcH7 Sgk ubiquitous

WWP1 human 8q21
Ce C2/WWx4/HECT 1 EGFR atrophin-1,CBLC
ubiquitous

WWP2 human 16q22.3

C2/WWx4/HECT
ENaC atrophin-1
hemato.

NEDL1, KIAA0322 human 7p13

C2/WWx2/HECT
dishevelled1

ubiquitous

SMURF1 human 7q21.1-q31.1

C2/WWx2/HECT
Smad7, Smad1,5,8, Smad4, MEKK2

ubiquitous

SMURF2 human 17q22-q23

C2/WWx3/HECT
SnoN, Smad2, TGFbR, RNF11
 Smad7
ubiquitous

Itch, itchy, AIP4, NAPP1 human 20q11.22-q11.23
a18H C2/WWx4/HECT
Lyn, Syk, Notch, EGFR, endophilin, occludin atrophin-1, CBLC, p45/NFE2, Numb, LMP2A
ubiquitous

UBE3A, E6AP human 15q11-q13

?/HECT 1
VCY2, UbcH6, UbcH7 TRRAP ubiquitous

TRIP12 human 2q36.1

WWE/HECT



ubiquitous

HECTD1 human 14q12

?/HECT



ubiquitous

FLJ20637 human 4q21.3

HECT



ubiquitous

KIAA0317 human 14q24.2

TM?/Filamin/HECT



ubiquitous

EDD, DD5, Hyd human 8q22

UBA/ZnF(UBR)/(polyA)/HECT
TopBP1 PR, CIB(KIP) progestin hemato.
 DNA damage

FLJ21156 human 1p34.1

HECT



ubiquitous

FLJ20333 human 14q12

RING(PHD)x2/HECT



testis

HUWE1, Ib772, LASU1, UREB1, HSPC272
 human
 Xp11.22

FH2/DUF913/UBA/WWE/HECT
histones




C20orf6, bA526K24 human 20p12.1






hemato.
RCC1 Ceb1 , HERC5
 human 4q22.1-q23

RCC1/HECT

cycE TNFa, IL1b, LPS
 ubiquitous

HERC2 human 15q13

RCC1x4/heme/ZnF/RCC1x12/HECT



ubiquitous

HERC3 human 4q21

RCC1x4/HECT

Ub
ubiquitous

HERC4, KIAA1593, DKFZP564G092 human 10q22.2

RCC1x2/HECT



ubiquitous

HERC1, p532, p619 human 15q22

RCC1x2/SPRY/WD40x4/RCC1x4/HECT

ARF1, Rab1, Hsp70
ubiquitous
IQ UBE3C, KIAA0010 human 7q36.3

IQ/HECT

Brn3b
ubiquitous
Ank
 HACE1
 human
 6q21

ANKx6/HECT
HACE1




 
 
 
Cullin
family name species apoptosis locus KO structure
regulators memo
Cullin Cul1, CDC53 human, Sc
7q34-q35 1 Cul CDC34, Skp1, ROC1, CAND1


Cul2 human
10q11.21
Cul



Cul3 human
2q37.1
Cul BTBs


Cul4A human
13q34 1 Cul CAND1


Cul4B human
Xq23
Cul



Cul5, VACM1 human
11q22-q23
Cul Muf1 Ets1

APC2 human, Sc
9
Cul APC1(BimE), 3(CDC27), 6(CDC16), 7, 8(CDC23)


CDC5, CDC5L human
6p21





CUL7, KIAA0076 human
6p21.1
APC10/Cul



PARC, KIAA0708 human sensitize 6p12.3
APC10/Cul/SPRY/RING(IBR)x2 p53


 
 
Skp1
family name species locus KO structure regulators memo
Skp1 Skp1, p19A human 5q22-q35.2
Skp1


Elongin B, TCEB1 human 15q13.3
Skp1


OCP2, TCEB1L human 5q31
Skp1


 
USPs
family name species apoptosis NF-kB locus KO structure (Ub)-substrate other binding partners regulators memo
USP





























 USP1 human

1p32.1-p31.3
UCH




USP2, UBP41 human

11q23.3
?/UCH

ARNT2, PTH, PGE2,cAMP

USP3 human

15q22.3
ZnF(UBP)/UCH




USP4, UNP human

3p21.3
DUSP/UCH
Rb, p107, p130


USP5, ISOT human

12p13
UCH/UBAx2




USP6, TRE2 human

17p13
TBC/UCH




USP7, HAUSP (human) human
involved
16p13.3
MATH/UCH p53 EBNA1, HSV1 Vmw110, ataxin-1 UVB casp
USP8 human

15q15.3
UCH/UBAx2




USP50
 human

15q21.1
UCH




USP9X human

Xp11.4
Evr1_Alr/?//UCH/?




USP9Y human

Yq11.2 1 ?/UCH/?




USP51
 human

Xp11.22






USP11, UHX1 human

Xp11.23
DUSP/UBQ/UCH
RanBPM


USP12 human

13q12.2
UCH

EV71

USP13 human

3q26.2-q26.3
ZnF(UBP)/UCH/UBAx2




USP14, TGT human

18p11.32 ax UBQ/UCH

Hoxd10

USP52, PAN2
 human

12q13.2-q13.3
UCH/Exonucelase III




USP15 human

12q14
DUSP/UCH

Hoxd10, AIRE

USP44
 human

12q23.1






USP16, UBPM human

21q22.11
cc/??/UCH




USP18, UBP43, ISG43 human

22q11.21
?/UCH ISG-prot.
IFNb, Lm, Pg

USP41
 human

22q11.21






VDU1, USP33
 human

1p31.1
ZnF(UBP)/UCH/DUSPx2 VHL



USP20, VDU2 human

9q34.2
ZnF(UBP)/UCH/DUSPx2 VHL
HCV

USP21 human

1q22
?/UCH
NEDD8 estrogen

USP22 human

17p11.2
ZnF(UBP)/UCH/DUSPx2




USP25 human

21q11.2
UBA/UIM/UCH/?




USP26 human

Xq26.2
?/UCH




USP29 human

19q13.43
?/UCH




USP31 human

1p36.12
UCH/DUSP/UBQ




USP48
 human

1p36.12
UCH//?




USP32, USP10 human

17q23.3
TBC/UCH
G3BP


USP34
 human

2p15
UCH




USP35
 human

11q13.4






CYLD human
mediate
 mediate 16q12.1 cyld1 CapGlyx3/UCH TRAF2 IKKg, TRIP
 NF-kB, TNFa, Hi,

USP45
 human

6q16.3
ZnF(UBP)/UCH




USP49, TRFP
 human

6p21.1






DKFZp451O034 human (partial), mouse

6q16.2
ZnF(UBP)/UCH




LOC255608 human

4p16.1
UCH/�H




USP46, FLJ12552 human

4q12
UCH




USP53
 human

4q27






USP36, FLJ12851 human

7p22.2
UCH/?




USP42
 human

7p22.2






USP37
 human

2q35






USP38, HP43
 human

4






USP39, SAD1
 human

2p11.2






USP40
 human

2q37.1






USP47
 human

11p15.3
UCH/?




USP54
 human

10q22.3






Other proteins
 
 
Group Protein apoptosis Locus KO 3D regulators memo
E1
 UBE1, A1S9, A1ST, GXP1, A1S9T, UBE1X (human)
Xp11.23

ARNT2, RANTES
UBE1L (human)
3p21



UBE1C (human)
3p24.3-p13
1
for NEDD8
FLJ10808 (human)
4q13.3



APPBP1 (human)
16q22


for NEDD8, binds to UBA3
SAE1, AOS1, SUA1, HSPC140 (human)
19q13.33


for SUMO
UBA2,SAE2 (human)
19q12


for SUMO
UBE1DC1 (human)
3q22.1

RANTES
APG7L, autophagy 7, GSA7 (human)
3p25.3-p25.2


for APG12L
E2
 UbcH2, UBE2H, UBC8, UBCH, E2-20K (human)
7q32

TNFa
UbcH5A, E2D1, UBE2D1 (human)
10q11.2-q21

FKHR
UbcH8, RIG-B, UBE2L6 (human)
11q12

PMA, IFNa/b, HCV IGSylation
UbcH9, UBE2E3 (human)
2q32.1



NCE2 (human)
2q37.3



UbcH10, E2C, UBE2C (human)
20q13.12



Kua-UEV (human)
20q13.2



MGC35130 (human)
1p31.3



HSPC150 (human)
1q32.1



UBE2Q, NICE-5 (human)
1q22



UBE2G, Ubc7 (human)
17p13.3

Blimp1
UBE2G2 (human)
21q22.3

Pax6
E2I, Ubc9, UBE2I (human)
16p13.3



FTS, Ft1 (human)
16q12.2


binds to Akt
Ubc3B, CDC34b (human)
9p13.2



Cdc34, UBE2R1 (human)
19p13.3



UBE2S, E2-EPF (human)
19q13.43

estrogen
Ubc12, UBE2M (human)
19q13.43

KF1B
MGC42638 (human)
Xq21.1



UbcM2 (human)
Xp22.31



E2A, Rad6, HR6A,UBE2A (human)
Xq24-q25 1
Ma, GM-CSF
UbcH5B, Ubc4, UBE2D2 (human)
5q31.3



E2B, Rad6B, UBE2B (human)
5q23-q31
1 Subst.P, LPS
UbcH5C, UBE2D3 (human)
4q24

ribavirin
UBE2E1, UbcH6 (human)
3p24.2-p24.1



UBE2E2 (human)
3p24.2



UbcH7, UBE2L3 (human)
22q11.21
1

Ubc13, UBE2N (human)
12q22



E2M (human)
19q13.2



HIP2, LIG, HYPG (human)
4p14



Ubc6p, CGI-76, NCUBE1, HSPC153, UBE2J1 (human)
6q16.1



UBE2J2, NCUBE2 (human)
1p36.33



DDVIT1, UBE2V2, MMS2 (human)
8q11.21



FLJ13855, HOYS7 (human)
17q21.32



FLJ12878, E2-230k (human)
17q25.1



FLJ11011 (human)
8q13.3



HBUCE1 (human)
7p13



LOC92912 (human)
15q23



for Bruce, see BIRs





Ub & related
 UBC (human)
12q24.3

A-Myb, B-Myb, Mt, hypoxia
UBB (human)
17p12-p11.2



RPS27A, CEP80, UBA80, UBCEP1, HUBCEP80 (human)
2p16



UBA52, CEP52, RPL40, HUBCEP52
19p13.1-p12



NEDD8 (human)
14q11.2



diubiquitin, FAT10, UBQ (human)
6p21.3



ubiquilin 1,UBQLN1, DA41, DSK2, XDRP1, PLIC-1 (human)
9q22



ubiquilin 2, Dsk2, CHAP1, LIC-2, N4BP4, PLIC2, UBQLN2 (human)
Xp11.23-p11

TNFa
ubiquilin 3,UBQLN3 (human)
11p15



UBL4, GDX, DXS254E (human)
Xq28



ANUBL1, AN1 (human)
10q11.22



RAD23A (human)
19p13.2



RAD23B (human)
9q31.2
 1


FAU, FAU1, RPS30 (human)
11q13



BAT3 (human)
6p21.3



A1U, UBIN, C1orf6 (human)
1q21



PRP21, SAP114, SF3A120, SF3A1 (human)
22q12.2



BMSC-UbP, SB132 (human)
15q23



DC-UbP (human)
5q35.2



MGC10067 (human)
5q33.3



elongin B (human)
16p12.3



HERPUD1, SUP, HERP, Mif1 (human)
16q12.2-q13



UBPH (human)
16p12



FLJ11807 (human)
10q24.2



LOC164153 (human)
1p13.2



MGC20470 (human)
11p15.4



FLJ22313 (human)
7p14.2



C7orf21, SB144 (human)
7q36.1



DDI1 (human)
11



C20orf86 (human)
20q13.32



DKFZP434N1923 (human)
8q24.3



MGC3123 (human)
17q21.31



ISG15, UCRP, IFI15, G1P2 (human)
1p36.33

PU.1, Ets1, IRF4, IRF8, TNFa, IFNa, IFNb, LPS, B-DNA, hsp65, Ld, Lm, Mt, Tg, MVA, VLP
RAP36 (human)
X

IFNa
OASL , see proteins for immunity,. For parkin, UHRF2, C20orf18, ICBP90 & USP14, see above
SUMO, BAGs & FAF, see other apotosis factors
APG12L APG12L (human, mouse, fugu, Dm, Ce, Sc, Sp)
5q21-q22



GABARAP, MM46 (human)
17p13.2


binds to GABA-A R
GABARAPL2, GEF2, GEF-2 (human)
16q22.3-q24.1



MAP1LC3B (human)
16q24.2



MAP1LC3A (human)
20cen-q13



TPRx2/cc/U CHIP, HSPABP2, NY-CO-7, SDCCAG7 (human)
16p13.12


TGFb
IAP associated DKFZP586F1524 (human)
17q11.1



RBAF600 RBAF600 (human)
1p36.13

ErbB4
Mov34
 Jab1, Mov34, SGN5, COPS5 (human)
8q13.1


COP9 signalosome subunit 5
p40, S12, PSMD7 (human)
16q23-q24


26S subunit  7
Pad1, PSMD14 (human)
2q24.3



STAMBP, AMSH (human)
2p13.1
 1

binds to Smurf2/RNF11
AMSH-LP (human)
10q23.32



eIF3-p40, eIF3g, EIF3S3 (human)
8q24.11



C6.1A (human)
Xq28



FLJ14981 (human)
19p13.3



KIAA1915 (human)
1p32.1




 
 
 

On-line review

Apoptosis and Ubiquitination by Lee & Peter (Immunol Rev 2003), Zhang et al. (Oncogene. 2004)
IkappaB degradation by Karin & Ben-Neriah (Annu Rev Immunol 2000)
PIAS family by Jackson PK (Genes Dev 2001)
Pml & COP1 by Reyes (Trends Biochem Sci 2001)
RING by Joazeiro & Weissman (Cell 2000), Borden (J Mol Biol 2000)
SOCS by Alexander & Hilton (Annu Rev Immunol 2004), by Alexander (Nat Rev Immunol 2002)
Ubiquitin/proteasome by Muratani & Tansey (Nat Rev Mol Cell Biol 2003)
Ubiquitin ligases and the immune response by Liu YV (Annu Rev Immunol. 2004)
Ubiquitination by Pickart (Annu Rev Biochem 2001), Hershko & Ciechanover (Annu Rev Biochem 1998)
Other Articles
The NEDD8 pathway is essential for SCF-beta-TrCP - mediated ubiquitination and processing of the NF-kB precursor p105 (Amir et al., 2002)


Links

Brief introduction for RING domain by T. Pawson Lab
Brief introduction for ubiquitin-proteosome pathway by M Pagano Lab



Copyright by Naohiro Inohara, Department of Pathology, University of of Michigan Medical School
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