| gene |
proposed name
|
products
(proteins) |
species |
function |
binding partners |
other features |
3D |
Motif Structure |
KO |
tramscriptional regulators |
regulation signals |
locus |
bcl-2,(5')
|
BCL2 |
Bcl-2alpha |
human,
mouse,
rat,
LThamster,
P.p.,
P.m.,
bovine,
deer,
cat,
chicken |
inhibit
/induce |
Bcl-2,
Bax
, Bcl-xL, Bcl-xS,
Hrk,
Bad,
Bak,
BAG-1,
c-raf,
R-ras,
c-ras,
calcineurin
Abeta, Bid,
Nip1,
Nip2, Nip3, Bim,
beclin,
BI-1,
Rad9,
Btf,
Bis,
Noxa,
Bmf,
Pin1,
FKBP38,
HAX1,
HSpin,
ITM2B(s),
Nur77,
PP1a,
calcineurin,
Cdc2 |
oncogene
of folicular lymphoma, Ub |
1 |
BH4/P?/BH3/BH1/BH2/TM |
L |
Aiolos,
B-Myb,
c-Myb,
v-Myb,
Brn-3a/(-),
AP1,
CREB,
p53,
E2F1,
c-Myc,
Rb,
AP2,
Bcl-6,
NF-kB,
NF-AT,
PAX8,
RAR,
RXR, GR,
WT1,
PU.1,
Pi1,
STATs,
SRF,
GATA-1,
GLI1, SP1/ER(1,
2),
FLI-1,
E2F1,
Mitf,
HOX11
|
IL1b,
IL2,
IL3,
IL4,
IL5(N),
IL6,
IL7,
IL8,
IL10,
IL15,
IL18,
IL21,
IL24,
AH,
G-CSF(-),
GM-CSF,
EGF,
VEGF,
IFNb,
PEDF,
bFGF,
TNF,
Fas,
OX40,
BAFF,
TACI,
CD3/CD28,
PMA,
BCR,
IGFBP2,
SST,
substance
P, PTHrP,
TRH,
CD31,
CD69,
CD90,
LTD4,
LPS,
Hp, Sd,
Mt,
Ang,
bombesin,
neurotrophins,
prolactin,
FLT3L,
SHH, irrrad,
ischemic
stress adaptation, progesterone,
O
stress, antioxidant,
GSH,
UVB,
NO,
3-NP,
OA,
PTDS,
DTDS, curcumin,
As2O3,
melarsoprol,
gluc.redct.,
PTK,
PP2A,
TGFa,
TGFb(N),
COX2,
DEX,
estrogen,
RA,
D3,
MEQ,
IGF-I,
Am80,
T3,
IKKb,
PI3K,
Akt,
PTEN,
Src,
JNK(?),
avb5, E-Cad.,
p38,
MKP1,
Par4,
Bit1,
AES,
TLE1,
hemopoietins,
Ask1,
Cdk1,
Cdk6,
v-cyclin, CDC2,
AUF1,
Nef,
JAK2,
JAK3,
NGF,
PLCg2,
PKCd, GH,
Plakoglobin,
minocycline,
tat,
finasteride,
caffeine
|
18q21.3 |
|
Bcl-2beta |
human,
mouse,chicken
|
|
|
|
|
BH4/BH3/BH1/BH2 |
|
|
|
|
bcl-x
(human, mouse)
|
BCL2L1 |
Bcl-xL |
human,
mouse,
rat,
pig,
chicken,
sheep,
bovine,
rabbit,
dog,
zebrafish(bclx, blp1) |
inhibit |
Bax,
Bcl-xS,
Bcl-xL,
Hrk,
Bik,
Bid,
Bad,
Bak,
Bcl-xL,
Bcl-2,
Bim,
Apaf-1
, BI-1,
Btf,
Aven,
Aiolos,
Bpr,
Diva/Bcl-B,
Bcl-G,
Bmf,
FKBP38,
HSpin,
Noxa,
p53,
Rad9,
SphK2,
Siva1,
chelerythrine |
highly expressed in erythroid
|
human (N,X),
rat,
xL/Bak |
BH4/P?/BH3/BH1/BH2/TM |
L |
GATA-1,GATA-4,
Ets2,
PU.1,
NF-kB,
CREB,
Bcl-6,
STAT3(-),
STAT5A&B,
STAT6,
Brn-3a,
EWS,
PAX3,
Pax5,
Smad1,
p53,
Bcl6,
AFX,
TEL,
c-Myc,
Csx |
TCR/CD3/28/PMA,
CTLA4/B7,
BCR,
EGF,
PEDF,
GM-CSF(-),
M-CSF,
TGFa/(-),
TGFb,
Bmp2,
Epo,
thrombopoietin,
IL1,
IL3,
IL4,
IL6,
IL8,
IL10,
IL10/12,
IL15,
IL18,
IL21,
TNFa,
OX40,
BAFF,
TACI,
4-1BB/4-1BBL,
HGF,
SCF,
DEX,
MUC1,
COX2,
estrogen,
progesterone,
CD40,
CD31,
hypoxia,
H2O2,
NO,
LPS,
Ec, Hp,
Ma,
Sm,
g-irrad.,
UVA,
DEX,
GADD153,
ECM, EGFR,
Taxol,
p38,
Akt/PI3K,
PKCb, estramustine,
3-NP,
MPTP,
Jnk,
c-Abl,
DDR1,
HTLVs,
tax,
HCV
core, HBx,
ALK,
NIK,
MKK4,
ERKs,
finasteride,
TCDD |
20q11.2 |
|
Bcl-xS
|
human,mouse,rat
|
promote
|
Bcl-2,
Bcl-xL,
Bcl-xS
|
|
|
BH4/BH3/TM
|
|
NF-kB
|
NGF(-),
IL18,
finasteride
|
|
|
Bcl-x
beta
|
human,
mouse,
rat,
chicken
|
inhibit/promote |
|
|
|
BH4/BH3/BH1/BH2
|
|
|
|
|
|
Bcl-x
DTM
|
mouse
|
|
|
|
|
BH4/BH3/BH1/BH2
|
|
|
|
|
|
Bcl-x
gamma
|
mouse
|
inhibit
|
|
|
|
BH4/BH3/BH1/BH2
|
1
|
|
|
|
bax (human,
mouse)
|
BAX
|
Bax
alpha |
human,
mouse,
rat,
bovine,
sheep,
cat,
dog,
deer,
frog,
zebrafish |
promote/inhibit |
Bax,
Bcl-2,
Bcl-xL,
Bid,
Bcl-B,
E1B
19K, Bif-1,
Ku70,
14-3-3sigma,
14-3-3q,
NS5A,
Asc |
function similar to Bak, Ub,
cleaved by calpain,
highest levels in hematopoietic cells
|
1 |
BH4/BH3/BH1/BH2/TM |
L |
p53(no
res.), p73,
p63,
AIRE,
Brn-3a, Gfi-1,
myc(-),
PLZF,
Sp1,
Ahr,
HMGs,
RARb,NF-kB,
Brn3a |
IL1b,
IL6(-),
IL8,
IL10,
IL24,
TNFa,
BAFF,
TACI,
TCR,
PMA,
LPS,
b-glucan, Hp,
Ma,
Mt,
Sd,
ischemia,
NO,
MEQ,
G-CSF,
SCF,
SST,
TRH,
prolactin,
ATP,
SSI-1,
DEX,
TGFb, COX2,
JAK3,PKR,
FRAP,
LATS1,
PAHs,
Expi,
H2O2,
ROS,
MG132,
DHA,
lactacystin,
g-irrad,
hypoxia,
YAP,
TCDD,
cisplatin,
KA,
calpain |
19q13.3-4 |
|
omega
|
rat |
inhibit |
Bax-alpha,
Bcl-2 |
|
|
BH4/BH3/BH1/BH2 |
|
|
|
|
|
sigma
|
human
|
induce
|
Bcl-xL,Mtd,Bax,Bak,Bfl1 |
|
|
BH4/BH3/BH1/(BH2)/TM |
|
|
|
|
| beta, gamma, delta,epsilon,
psi,
zeta |
human |
|
|
|
|
|
|
p53 |
|
|
|
epsilon(2)
|
|
induce
|
Bcl-2, Bcl-xL, Baxalpha |
|
|
BH4/BH3
|
|
|
|
|
|
kappa
|
rat,
mouse
|
|
|
|
|
BH3/BH1/BH2/TM
|
|
|
|
|
| bak/bak2/bak3(mouse) |
BAK1 |
Bak |
human,
mouse,
rat,
pig,
sheep |
promote/inhibit |
Bcl-xL,
Bcl-2,
Mcl1,
E1B
19K, E6AP |
function similar to Bax, Ub,
highest levels in epithelium, preB
|
xL/Bak |
BH4/BH3/BH1/BH2/TM |
L |
p53,
E2F1,
RARb,
NF-kB |
estrogen,
progesterone,
IFNg,
IL1a,
RANTES,
PMA,
LPS,
EV71,
g-irrad.,
Raf,
IL6(-),
DEX,
UV,
camptothecin,
butyric
acid |
6p21.3-.2 |
|
|
N-Bak
|
mouse
|
promote/inhibit |
|
|
|
|
|
|
|
|
mcl-1
|
MCL1 |
Mcl-1 |
human,
mouse,
rat,
sheep,
pig,
dog,
chicken,
zebrafish
(a, b),
carp |
inhitit |
Bax,
Bad,
Bmf,
Mtd,
DAD1,fortilin,
tankyrase
1 |
highest level in myeloid, lymphocytes, APCs, Macrophage-inducible
gene, casp3
|
|
BH4/BH3/BH1/BH2/TM |
L |
SRF,
AP1,
Elk-1,
E2F1,
E1A,
PU.1,
Stat3,
CREB,
c-Myc |
IL3,
IL6,
IL7,
TNFa,
IFNg,
GM-CSF,
SCF,
PDGF,
Subst.P,
HGF,
VEGF,
Thrombin,
LMP1,
E1A, PI3K,
DNA
damage, UVB, PMA,
LPS, CSBG,
Ct,
Lm,
Ma,
Mt,
Ng,
Ye,
HHV8,
UV,
Epo,
gonadotropins,
estrogen,
myocardial
infarction, cAMP,
Akt,
p38,
Jak,
PI3K,
IEX1S,
Jnk,
Nef,
flavopiridol,
DIM,
ER,
AdV,
TCDD |
1q21 |
|
Mcl-1sDTM,Mcl-1s
|
human
|
induce
|
|
|
|
BH4/BH3
|
|
|
|
|
| bfl-1/A1 |
BCL2A1 |
A1/Bfl-1/GRS |
human(a,b,c),mouse(a,b,c,d),
rat,
chicken |
inhibit |
Bax,
Mtd,
ING1 |
highest level in myeloid, preB, APCs, lymphocytes
|
|
BH4/BH3/BH1/BH2/TM |
L |
NF-kB,
AP1,
STATs,
C/EBPa,
C/EBPb,
HMG-IC |
GM-CSF,
G-CSF,
LPS,
b-glucan, Ld,
Lm,
Ma,
Mt,
Ng,
Tg,
HHV8,
CD40,
CD31,
TNFa,
IL1b/TNFa,
IFNa,
TCR/CD3,
4-1BB,
PMA,
BCR,
TGFb,
PLCg2,
D3,
DEX,
IL10,
irrad,
Am80,
T3,
butyric
acid, DIM |
15q24.3 |
| bcl-w |
BCL2L2 |
Bcl-w |
human,
mouse,
rat |
inhibit |
Bim,
Bmf,
PP1aa |
important for spermatogenesis (1,
2),
highest level in brain
|
L |
BH4/BH3/BH1/BH2/TM |
L |
|
ischemia,
HGFR,
Subst.P,
TCDD |
14q11.2-q12 |
|
mtd*
|
BOK
|
Bok-L/MTD
|
human,
rat,
mouse,
chicken
|
promote
|
Mcl-1,
Bfl-1
|
highest level in bone marrow (but not in ovary/testis)
|
|
BH4/BH3/BH1/BH2/TM |
|
E2F1,
p53
|
FSH,
SCF,
serum,
TCDD
|
|
|
|
Bok-S
|
rat
|
promote
|
|
|
|
BH4/BH31/BH2/TM |
|
|
|
|
| diva |
BCL2L10 |
Diva/Boo,
Bcl-b/Nrh |
mouse,
rat,
human |
promote/(-)/inhibit |
Apaf-1,
vBcl-2,
Bcl-xL,
Bcl-xS,
Bcl-2,
Bik,
Bak,
Diva, Bax |
ovary/testis-specific in mouse adults |
|
BH4/BH3/BH1/BH2/TM |
1 |
|
|
15q21 |
bcl-g
|
BCLG
|
Bcl-GL
|
human (S,
M,
L),mouse,
rat
|
promote
|
Bcl-xL,
Bcl-2
|
testis-specific
|
|
?/BH3/(BH1)/BH2
|
|
|
|
12p12
|
|
Bcl-Gs
|
human,
mouse
|
promote
|
Bcl-xL
|
|
BH2
|
|
|
|
|
|
MIL1
|
BCL2L13 |
Bcl-Rambo/MIL1
|
human,
mouse,
rat
|
induce
|
|
|
|
BH4/BH3/BH1/BH2/Ex/TM |
|
|
|
22q11
|
|
bpr
|
BCL2L12
|
BPR
|
human,
mouse,
rat
|
|
Bcl-xL
|
highest level in preB, bone marrow, lymphocytes
|
|
BH2
|
|
c-Myc
|
|
19q13.3
|
|
BPR variant 1
|
human
|
|
|
|
|
|
|
|
|
|
bfk
|
LOC148280
|
Bfk
|
human,
mouse,
rat
|
promote
|
|
|
|
BH4/BH3/BH1/BH2 |
|
|
|
1p13.1
|
|
NR-13
|
|
NR13
|
quail,
chick,
zebrafish
|
inhibit
|
|
|
|
BH4/BH3/BH1/BH2/TM |
|
NF-kB
|
v-src
|
|
|
xRII
|
|
xRII
|
X.laevis
|
inhibit
|
|
|
|
BH4/BH3/BH1/BH2/TM |
|
|
|
|
|
xR1
|
|
xRI
|
X.laevis
|
|
|
|
|
BH4/BH3/BH1/BH2/TM |
|
|
|
|
|
Ced-9
|
|
Ced-9
|
C.elegans,
briggsae,
|
inhibit
|
Ced-4(1,2,3,4,5),
Egl-1
|
|
1,
w/Ced9 |
BH4/BH3/BH1/BH2/TM |
1 |
|
|
3 |
|
drob1
|
|
Drob1/DEBCL/BOK/BG1/Dborg1
|
fly,
Ag
|
promote
|
|
|
|
BH4/BH3/BH1/BH2/TM |
|
|
UV
|
42E-43A
|
|
buffy
|
|
Buffy
|
fly,
Ag
|
inhibit
|
|
|
|
BH4/BH3/BH1/BH2/TM |
|
|
|
2 48A-E
|
|
bhp1
|
|
BHP1
|
sponges(G.c.,
S.d.)
|
inhibit
|
|
|
|
BH4?/3?/BH1/BH2/TM |
|
|
|
|
| harakiri |
HRK |
Hrk/DP5,
Bid3
|
human,
mouse/rat |
promote |
Bcl-xL,
Bcl-2,
E1B
19K, p32 |
BH3-only
subfamily, RGCs,
4-cell
embryo |
|
BH3/TM |
1
|
DREAM,
E2F1 |
NGF,
b-amyloid,
IL3, Fas,
T3,
progesterone,
methylation,
KA
, JNK,
calcineurin,
TCDD,
KCl
|
12p13.1. |
| bik/nbk/blk |
BIK |
Bik/Nbk/Blk |
human(b |