Index Caspase CARD/DED/BIR Bcl-2  DD TNF/TNFR Kinases ILs Viral Lipid Engulf TF RING Toll Other Apop Other NFkB Alphabet

Proteins for Immunity

TLRs, related protein and non-lectin/Ig type pathgen recognizing proteins (Nod family is here)
 
Group Protein Species apoptosis
NF-kB act.
 Binding Partner Structure KO gene locus regulators 3D memo
TLR

























 Toll D.m.,D.p.,D.s., S.a., A.g.
induce
 Tube, MyD88 LRR/TM/TIR 1 1
LPS, IL13, PMA TIR anti-fungal
TLR1 human, mouse, sea urchin
 
 (BLP) LRR/TM/TIR L
4p14 IFNg, influenza A, Sendai, Hp TIR anti-bacterial
TLR2 human, Mf, mouse, bovine, chTLR2(chick), sea urchin
mediate
 induce
 MD2, SP-A, zymosan, PGN, (L TA, BLP, LPS(?), porins, glycolipid, hsp70, hsp60), TRIF, MyD88, TRIAD3
 		LRR/TM/TIR L 1,2,3 4q32 NF-kB, STAT5, Sp1, Sp3, TLR4, LPS (-), PGN, LTA, Lm, TNFa, Fas, IFNa, IFNg, DEX, GCSF, TCR, PMA, Ec, Sa, influenza A, Sendai TIR, TIR(P681h) anti-bacterial
TLR3 human, mouse, bovine, (induce?)
 
 (dsRNA, mRNA), TRIF, TRIAD3
 		LRR/TM/TIR 1
4q35 TRAIL, IFNa/b, IFNg, STAT1, LPS, LTA, dsRNA, B-DNA, Ec, Lm, Sa,  LLO, PMA, IFNAR1, TRIF
anti-viral
TLR4 human, mouse, rat, bovine, dog, cat, chimpanzee, horsebaboon induce
induce
 (LPS, sHA, hsp70, hsp60, heparan sulfate proteoglycan), CD14, MD2, MyD88, TLR5, BTK, JIP3, TRIAD3, NAD(P)H oxidase
 LRR/TM/TIR L, d 1, m 9q32-q33 PU.1, AP1, MIF, TNFa, IFNa, IFNg, LPS, LTA, Lm,  hypoxia, Oxidant stress, PMA, estrogen, influenza A, Sendai, MIF
anti-Gram negative
TLR5 human, mouse, trout

flagellin, TLR4, TRIAD3
 		LRR/TM/TIR
1 1q41-q42 Ec, Hp, Lm, Sa, flagellin
anti-bacterial
TLR6 human, mouse

(BLP), BTK LRR/TM/TIR 1 1 4p15.1 PMA, Fas, LPS, LTA, Hp
anti-bacterial
TLR7 human, mouse

(ssRNA, imidazoquinolines, R-848, CpG) LRR/TM/TIR

Xp22.3 IFNa,  IFNg, LPS, LTA, Ec, Sa, influenza A, Sendai, PMA, MeDNA
anti-viral
TLR8 human, mouse

(R-848) LRR/TM/TIR

Xp22 LPS, PMA

TLR9, CpG1 human, mouse, pig, cat, dog, bovine,

(DNA,CpG), Ras, BTK, TRIAD3
 		LRR/TM/TIR L
3p21.3 CSF1, IgG, MeDNA
anti-bacterial
TLR10 human


LRR/TM/TIR
1 4p14 IgG

TLR11 mouse
induce
LRR/TM/TIR




uropathogenic bacteria
TLR12 mouse


LRR/TM/TIR





TLR13 mouse


LRR/TM/TIR





SIGIRR/TIR8 human, mouse
inhibit
LRR/TM/TIR L
11p15.5


18 wheeler D.m., Bm


LRR/TM/TIR 1 1 2R 56F7-56F8

anti-bacterial
Toll5/Tehao D.m., D.s.


LRR/TM/TIR
1



Toll7/Tollo/Tak1 D.m.


LRR/TM/TIR
1



Toll4/CG18241 D.m.


LRR/TM/TIR
1 2L


Toll6/CG7250 D.m.


LRR/TM/TIR
1 3L


CG5528 D.m.


LRR/TM/TIR
1 3L


Toll7/CG8595 D.m.


LRR/TM/TIR
1 2R


Toll3/DmMstProx D.m.


LRR/TM/TIR
1



Toll-related (under construction) grasshopper, mosquito (1, 2, 3, 6, Trex, Toll9),G.p.p.


TIR(partial)





Tol-1 C.e.


LRR/TM/TIR 1 1 I


RP105, CD180 LY64 (human), RP105(mouse)
supress
MD1 LRR/TM

5q12 AIRE, PMA, Ec, Hp, Sa

Synleurin human


LRR/TM

5q12


Adaptors








 MyD88 human (S), mouse, frog, D.m.
induce
induce
 IRAK,IRAK-2, IRAK-M, IL-1R, FADD, MAL DD/TIR L 1,2p21.3 3p21.3 IL-6, IRF1, STAT3, STAT5, IFNa/b, IFNg, IL6, IL15, IL21, TNFa, TRAIL, M-CSF, MDP, Ec, Hi, Mt, Sa, Ye, Yp, LPS, PMA, TCDD; TGFb
Ub
Tube D.m.
induce
 Pelle, Toll, Cactus DD 1 1

Tube/Pelle DD
TIRAP, MAL human, mouse
induce
 TLR4/MD2, MyD88, IRAK2, MAL /TIR L 1 11q24.2 LPS

TRIF, TICAM1, LPS2 human, mouse
induce
induce
 TLR2, TLR3, IRF3, RIP, RIP3
 /TIR/RHIM L
19p13.3 NF-kB, TNFa, IL1, IFNb, PAMPs, Hoxd10
for TLR3, 4, targets
TIRP, TRAM, TICAM2 human, mouse
induce
 TLR4, TRIF, IL1R, IRAKs, TRAF6 TIR 1
5q23.1


SARM, TIR-1 (Ce), CG7915 (Dm)
 human, mouse, rat, Ce, Dm, Ag,


ARMs/SAMx2/TIR

17q11


Tollip human, mouse, C.e.
(inhibit)
 Tom1, IRAK, IL1R
 C2//CUE
1 11p15.5 VLP
Ubiquitination
Pellino (Pli)
 Dm, Ce

Pelle






Pellino 1(human, mouse)
mediate
 IRAK, IRAK4, TRAF6


2p13.3 LPS, TRIF

Pellino 2(human, mouse)

IRAK, IRAK4, Bcl10


14q21 AP1

RNA helicase

 MDA5, HELICARD
 human, mouse,
 ( IRF3)
 induce
 (polyIC)
 CARD/AAA/helicase
 L
2p24.3-q24.3
 IFNb, mezerein, B-DNA
casp, B, T, APCs
RIG-I, DDX58
 human, mouse, bovine, pig, chicken, fugu,
 induce (also IRF3)
 induce
CARD/AAA/helicase L
9p12
 IFNb


VISA, IPS1, MAVS, CARDIF
 human, mouse, rat,
induce
CARD/TM L



NS3/4A
Kinase  IRAKs for IRAK family, see kinase    







ligand? SPAETZLE D.m.
 
 Toll NGF 1 1
fungi inf.


HMGB1 human
induce
HMG 1




PGRP




 PGRP-Ialpha, PGLYRP3
 human, mouse, rat

PGN ami2x2

1q21

esophagus, fetal liver
PGRP-Ibeta, PGLYRP4
 human, mouse

PGN ami2x2

1q21

esophagus
PGRP-S, tag7, PGLYRP, PGLYRP1
 human, mouse, rat, bovine

PGN ami2 1
19q13.2-q13.3
TCR, Hf, Hp bone marrow
PGRP-L, PGLYRP2
 human, mouse, pig

PGN ?/ami2

19p13.13

liver
PGRP D.m. (SA, SB1, SB2, SC1, SC2, SD)

PGN ami2




mediate Toll pathway
PGRP related phage lysozyme,[T7, T3, fYe03-12] bacterial[M.t., S.c., Cg, ]

PGN ami2



KAmt, w/RNApol, LB
Lysozyme
 LYZ

 lysozyme, LYZ (human, mouse M, P, rat)


lysozyme

12q14.3 MEF, GABP, RA, LPS, Sp, HCV, NRF2, TNF, TRAF2/TRAF5
APCs
LYZL6, LOC57151 (human)


lysozyme

17q11.2

testis
SPACA3, LYC3, LYZL3, SLLP1, ALLP17 (human)


lysozyme

17q11.2

testis
LYZL4, LYC4 (human)


lysozyme

3p22.1

testis
LYZL1, LYC2,  MGC33408 (human)


lysozyme

10p11.23

testis
LYZL2  (human)


lysozyme

10p11.23

testis
PNPK6288, LOC389852 (human)


lysozyme

Xp11.23

testis, skin
lactalbumin alpha, LALBA (human)


lysozyme

12q13

mammary gland
SLT
 LYG1, LOC129530, SALW1939, Lysozyme G (human, mouse, chicken, Xl, zebrafish, Ec)


SLT



2q11.2

tongue
LYG2,  LYGH (human, mouse)


SLT

2q11.2


Other

























 CD14 CD14 (human, mouse, rat, horse, bovine, rabbit)
mediate
 mediate LPS, PGN LRR-GPI L, d 1 5q31.1 AP-1, AIRE, Sp1, MEF2D, PPARg, IFNg, PMA, TGFb1, IL13, LPS, Pg, Hf, C/EBPs, estrogen, PGE2, PMA, cAMP, ethanol 1
 anti-bacterial, APCs
ML


 MD2 (human, mouse, C. hamster, bovine)

TLR4, LPS, LTA, TLR2, MD2 ML 1 1,2 8q13.2 IFNg, SOCS3, PMA
APCs
MD1, Ly86 (human, mouse)

RP105, (LPS) ML 1 1,2 6p24.1 Myb, PMA, Tc
APCs, B
Npc2, HE2 (human)

cholesterol ML npc
14q24.3 AIRE 1 ubiquitous, highest in APCs
GM2A (human)

GM2 ML 1
5q31.3-q33.1
1 placenta, bronchia, preB
LBP

 LBP (human, mouse, rat)

LPS, PGN
 LBP L
20q11.23-q12 NRF2, RA, A2aR, Pg, Hp
liver
BPI (human, rabbit, bovine, Ce, At)


LBP

20q11.23-q12 Hp 1 neutrophil
BPIL1, RYSR, LPLUNC2 (human)


LBP

20q11.22

airway
BPIL3, LPLUNC6 (human)





20q11.22

alfactory epithelium
BPIL2 (human)


LBP

22q12.3

epidermis, digits
PLTP, LTP2 (human, mouse, rabbit, pig,)


LBP 1
20q12-q13.1 LXR, FXR, hypoxia, bile acid, fenofibrate, ErbB4
epidermis
LPLUNC1, C20orf114 (human)





20q11.1

airway
RYA3, LPLUNC3, dJ726C3.4、C20orf185 (human)


LBP

20q11.21


RY2G5, LPLUNC4, dJ726C3.5, C20orf186 (human)


LBP

20q11.21


CETP (human, rabbit)


LBP

16q21

lymph node, placenta, liver
Mindin

 Spondin 2, M-spondin, Mindin, SPON2 (human, mouse)


FS/TSP1 1
4p16.3

NK
spondin 1, F-spondin, SPON1 (human, mouse)


FS/TSP1x6

11p15.2


CCF earthworms,  CG6895-PA(Dm)


beta 1,3-glucanase





BRICHOS
 		SP-C, PSP-C, SFTP2, SP5, SFTPC (human, mouse, rat)

CD14, LPS BRICHOS L
8p21 TTF1, GATA6, TAZ
lung
LECT1, CHM1, CHM-I, BRICD3, Chondromodulin (human, mouse, rabbit, chicken, zebrafish)


BRICHOS L
13q14-q21 Sp3, TGFb, FGF2, PTHRP

ITM2B, BRI, FBD, ABRI, BRI2, E25B, E3-16, BRICD2B (human, mouse, Ce, zebrafish)


BRICHOS dmt
13q14.3


ITM2A, E25A, BRICD2A (human, mouse)


BRICHOS

Xq13.3-Xq21.2


tenomodulin, TNMD (human, mouse, rat,


BRICHOS

Xq21.33-q23


BRI3, E25, Itm2c (human, mouse, chicken)


BRICHOS

2q37

APCs
GDDR (human)


BRICHOS

2p13.3


AMP18 (human)


BRICHOS

2p13.2


albumin albumin, ALB (human)

PG albumin x3

4q11-q13 C/EBPa, NF-IL6, HNF1, AP1, p53, HGF, HB-EGF, TNFa, DEX, H-Ras
Liver
alpha-fetoprotein, AFP (human)


albumin x3

4q11-q13
 NF-kB, C/EBPs, FOXA, Nkx2.8, T3R, p53, ATBF1, DEX/GR, HNF1, HNF3, HNF4, AP1, RA/RAR/RXR, TGFb, HGF, 12-PGJ2, osmotic pressure, H-Ras, Raf, Rif, Butyrolactone I
fetal liver
apha-albumin, ALB2, ALBA, AFAMIN (human)


albumin x3

4q11-q13

liver
DBP (human)


albumin x2

4q11-q13


Serpin Serpin27A (Dm)





4q11-q13

mediate Toll pathway
C114 C114, PRKRIP1 (human, mouse, Dm, Ce, Nc)

dsRNA, PKR cc

7q22.1 IL11

Ig-related Proteins
 
Group Protein Species apoptosis
NF-kB act.
 Binding Partner Structure KO gene locus regulators 3D memo
IgG sup. Ig Kappa (IGKC: ex: human)





2p12 NF-kB, ARNT2, TCR/CD3, PMA, TNFa, IL12, IL15, Hp, VDR



Lambda(IGLC1: ex: human)





22q11.2 TIMP1



heavy (human: const. ex: a1,a2, g1, g2, g3, g4, d, e,)



L
14q32.33 LPS, Hp, Sm, IL10/12, estrogen, IL5, Blimp1, Lyn, ARNT2, TIMP1


TREM1 TREM1(human, mouse) inhibit
DAP12 IG/TM

6p21.1 LPS, fungi
APCs


TREM2 (human)

DAP12
 IG/TM 1
6p21.1




TLT1 (human)


IG/TM

6p21.1




TREML2, FLJ13693, C6orf76 (human)


IG/TM

6p21.32




RAGE, AGER  (human, mouse, rat, bovine)


IGx2/TM

6p21.3 IFNa


DAP12 DAP12, TYROBP (human, b, mouse, pig, cow)
inhibit
DAP12, CD94, KIR2DS2, TREM1, TREM2, ZAP70, Syk, NKG2D, NKp44 TM/ITAM L
19q13.1 TCR
NK, DC


DAP10 (human, mouse, pig)

NKG2D, PI3K TM L
19q13.1

B, T

TCR TCRa (ex:human) induce activate antigen, CD3, CD8, SH2s, Lck, TCRb IG/TM(VJC) L
14q11.2 LEF1, TCF1, CREB, HIV1,  TNFa, ALK1 1 T


TCRb (ex:human)

antigen, superantigens, CD3, TCRa IG/TM(VJC) 1
7q35 NF-kB,Hp, HCV, 1


TCRg (ex: human)

TCRd IG/TM(VJC)

7p15-p14 TCR, IL3, Mad1



TCRd (ex:human, mouse, rat, sheep, chicken, Xl)

TCRg IG/TM(VJC) 1
14q11.2 T3, IFNa,  Notch, PPARa



CD3g (human, mouse, rat, bovine, sheep) induce activate TCR IG/TM/ITAM(AP2) 1
11q23 SDF1, Mad1, Tc, HCV, camptothecin, TIMP1
T, NK


CD3e (human, bovine, sheep, dog, chicken)

TCR
1
11q23 Tc
T


CD3d  (human)

TCR IG/TM/ITAM 1
11q23 IFNa
T


CD3zeta, CD3Z (human, mouse,chick)

Syk, ZAP70, NKp46 TM/ITAMx3 1
1q22-q23 O2 stress, PMA, PPARa
NK, T

CD79 CD79A, mb1, Ig-alpha (human, mouse)

Ig/CD5/CD19/CD22/CD79b IG/TM/ITAM 1
19q13.2 Pax5, TIMP1
B


B29, CD79B, Ig-beta (human, rat)

Ig/CD5/CD19/CD22/CD79a IG/TM/ITAM

17q23 EBF, OBF1, GR, c-Myc, UVB, Lyn, TIMP1
B

CD8 CD8alpha, Lyt23 (human, mouse, rat, chick) induce/ inhibit activate MHC-I, Lck IG/TM L
2p12 ,ITM2A, CREB, HIV1, VLP, Ikaros L T, NK, for MHC-I


CD8beta, CD8B1 (human, mouse, rat, chick)


Ig/TM 1
2p12 CsA/FK506, IL15, LiCl, MVA
T

CD4 CD4, L3T4 (human,mouse, rat, chick)
induce
 activate MHCII, TCR, LCK IGx3/TM L
12pter-p12 c-Myb, Elf1, Ets1,Ets2, MAZ, ZEB, HES1, TCR, PMA, HHV6, HHV7, HBx
APCs, for MHC-II

IgE Fc R, FceRI  IgE Fc R a,  FCER1A (human, mouse, rat)


IGx2/TM

1q23 STAT6, IL4, GATA1, Elf1, USFs, GCSF, BMP2 1 APCs


IgE Fc R g, FCER1G(human, mouse, rat)


TM/ITAM 1
1q23 TCR, Tc
APCs, NK

IgG Fc gamma R IgG Fc R 1, FCGR1A, IGFR1, CD64 (human)

high affinity for Fc g, periplakin IGx3/TM L
1q21.2-q21.3 IFNa, IFNg, IL1, LPS, Tc, D3, estrogen



IgG Fc RII, FCGR2A, IGFR2, CD32 (human)
inhibit
 induce low affinity for Fc g IGx2/TM L
1q21-q23 LPS, IL8, IL10, SCF, DEX, hypoxemia
APCs


IgG Fc RIII, FCGR3A, IGFR3, CD16 (human a, b)

low affinity for Fc g IGx2/TM L
1q23 IFNg, IL2, IL3, IL8, HCV, ARNT2, IFNa, staurosporine
NK

Fc alpha R Fc alpha R, IgA Fc R, CD89, FcaR (human)


IGx2

19q13.2-q13.4 C/EBPa, Fas, Elf-1, camptothecin
APCs, Eo

CD7 CD7 (human, mouse)
mediate
CD3, CD45, PI3K, IG/TM/YEDM 1
17q25.2-q25.3 Notch, Ca2+, cAMP, IL5
NK, T

CD19 CD19 (human, mouse, pig)
mediate/ inhibit
 mediate CD2, CD9, , CD81, CD225, Lyn, c-Abl, PI3K IGx2/TM L
16p11.2 Pax5, Lyn(P), CD81
B cell, RP105

B7 CD80, CD28LG1, B7-1 (human, mouse, rat)
prevent
CD28, CTLA4 IGx2/TM L
3q21 NF-kB, Bcl6, HLX, TCR/CD3, IL1, IL4, IL10, jagged-1, GM-CSF, TNFa, Fas, IFNb, IFNg, Hp, Yp, dsDNA, HIV Vpr, MVA, S-27609, LeIF, triptolide L


CD86, CD28LG2, B7-2 (human, mouse, rat)
prevent
CD28, CTLA4, MIR IG/TM L
3q21 NF-kB, ARNT2, BCR, IFNb,IFNg, TNFa/IFNg, CD40L, C4BP, LPS, MDP, S-27609, Hp, Lm, Tc, UDP-Glc, IL-3, IL10, IL18, GM-CSF, jagged-1, Jnk, p38, DEX, D3, PGE2, triptolide, estrogen, camptothecin
APCs


GL50, B7H2, B7RP1, ICOSL, LICOS(human, mouse)

ICOS IGx2/TM L
21q22.3 A2aR 1


B7H1, PD-1 ligand, PD-L1 (human, mouse)

PD-1 IGx2/TM 1
9p24 TNFa, IFNg, LPS, Hp, Sm, STAT1, TLR4,dsRNA, B-DNA



PDL2, B7-DC (human, mouse)





9p24.2 IL4, IFNg, LPS, Ag, Sm, STAT6,



B7H3(human, mouse), 4Ig-B7-H3 (human)


(IGx4+)IGx2/TM L
15q23-q24 PMA/Io, Inf.cyt.
IFNg


B7-H4, B7S1, B7x (human, mouse, rat)
(-)
BTLA IGx2/GPI

1p11.1



CD28 CD28, Tp44(human, mouse, rat,chick)
inhibit/ mediate
 activate B7 family IG/TM L
2q33-q34 TNFa, TCR, Mt, MVA, Subst.P
T,  targets, IL2, CD30, AP-1 ,NF-ATp


CTLA4, CD152(human, mouse, rat)
mediate/ inhibit
 supress
IG/TM L
2q33 Tprim., OX40, AIRE L T


ICOS/AILIM(human) prevent

IG/TM L
2q33 TNFa, LPS, IL4, IL12, IL23



PD-1, PDCD1 (human, mouse) involved?
PDL1, SHP2 IG/TM/ITIM L
2q37.3 Pax5, Egr1, Nur77



BTLA (human)

B7H4, SHP1, SHP2 IG/TM/ITIM

3q13.2

B

CD1 CD1a (human, pig, horse)

glycolipid, B2M IG/TM

1q22-q23 GM-CSF, Hp, MVA
Thy


CD1b (human, rabbit, sheep b1, b2, b3, guinea pig b1, b2, b3, b4, horse)

glycolipid, B2M IG/TM

1q22-q23 VEGF, IL13
 L Thy


CD1c (human, guinea pig c1, c2, c3)

glycolipid, , B2M IG/TM

1q22-q23 IL13
Thy, APCs, B


CD1d (human, mouse d1, d2, rat d1, d2, sheep)

glycolipid, B2M, MHCII, gp180 IG/TM L
1q22-q23 Sp1, IL13, LPS, hsp65, androgen, D3
APCs


CD1e (human, monkey, rabbit, guinea pig)

glycolipid IG/TM

1q22-q23

Thy

semaphorin semaphorin B, SEMB, SEMAB, SEMA4A (human)





1q22
 Ma



semaphorin D, collapsin 1, SEMA3A (human)
induce


1
7p12.1 FKHR



SEMA3B, SemA, SEMA5, SEMAA, LUCA1 (human)
 induce




3p21.3




SEMA3C (human)





7q21-q31 TNFa



SEMA3D (human)





7q21.11




SEMA3E (human)





7q21.11




semaphorin J, SEMA4D , CD100 (human, mouse)

CD45, CD72 Sema/PSI/IG/TM 1
9q22-q31 CD40, LPS
B, T, NK, APCs


SEMA5A,semF, SEMAF (human)





5p15.2 VEGF, ARNT2



SIMA7A, JMH, CD108 (human, zebrafish)

CD232 Sema/PSI/IG/GPI

15q22.3-q23



plexin PLXNA1, PLXN1, NOV (human, mouse, Xl, Dm, Ce)

neuropilin-1, SEMA3A Sema/PSIx3/IGx4/TM(HAMP)/RasGAPx2

3q21-qter CIITA



PLXNA2 (human, mouse)


Sema/PSIx3/IGx4/TM(HAMP)

1q32.2 b-catenin



PLXNA3, SEX (human, mouse)


Sema/PSIx3/IGx4/TM

Xq28




PLXNA4 (human, mouse)


Sema/PSIx3/IGx4/TM

7q32.3




PLXNB1, PLXN5, SEP (human, mouse)


Sema/PSIx3/IGx3/cc

3p21.31




PLXNB2 (human, mouse)


Sema/PSIx3/IGx3/cc

22q13.33 estrogen



PLXNB3 (human, mouse)





Xq28




PLXNC1, VESPR (human, mouse)


PSIx2/TIG/IG/TM

12q23.3 FSH



PLXND1 (human)





3q21.3



IGSF IGSF2, V7, CD101 (human)


IGx7/TM

1p13

NF-ATc


IGSF3 (human)





1p13


Group Protein Species apoptosis
NF-kB act.
 Binding Partner Structure KO gene locus regulators 3D memo

LIR ILT2, LIR1, CD85J, MIR7, LILRB1 (human)
inhibit?
HLA-A, B, HLA-G1, HLA-F (MHC-I), SHP1 IGx4/TM/ITIM

19q13.4
1 APCs, inhibit T act.


ILT4, LIR2, LILRB2, CD85D (human)

HLA-A,B,G1,F IGx4/TM/ITIM

19q13.4 Fas, IL13



LIR3, ILT5, LILRB3, CD85A, LILRB3 (human)

MHC-I IGx4/TM/ITIM

19q13.4




LIR4, ILT6, HM43, CD85E, LILRA3 (human)

FcRgamma IGx4

19q13.4 TIMP1
APCs


LIR5, ILT3, LILRB4, CD85K  (human)

MHC-I IGx2/TM/ITIM

19q13.4 St PhoP, Fas
APCs


LIR8, LILRB5, CD85C (human)

FcRgamma IGx4/TM/ITIM

19q13.4




LIR7, ILT1, CD85H, LILRA2 (human)

FcRgamma IGx4/ITAM

19q13.4 IFNa
APCs


ILT7, CD85G (human)

FcRgamma IGx4/ITAM

19q13.4

mDC


ILT8, CD85B (human)

FcRgamma IGx4/ITAM

19q13.4

APCs


LIR6, LILRA1, CD85E (human)

FcRgamma IGx4/ITAM

19q13.4




ILT11, LIR9, CD85F (human)

FcRgamma IGx2/ITAM

19q13.4

preDC


ILT10, CD85M (human)

FcRgamma IGx3

19q13.4




LAIR1 (human)
inhibit?
Ep-CAM, SHP1,SHP2,


19q13.4 G-CSF
APCs, B, T, NK

KIR (for NK) KIR2DL1/NKAT1(human)

HLA-C4,2,5,6 (MHC-I), B4 (/w S1), SHP1, SHP2 IGx2/TM/ITIMx2

19q13.4

NK


KIR2DL2/NKAT6(human)

HLA-C1,3,7,8 (MHC-I) IGx2/TM/ITIMx2

19q13.4
L NK


KIR2DL3, NKAT2, CD158b(human)

HLA-C1,3,7,8 (MHC-I) IGx2/TM/ITIMx2

19q13.4
1 NK


KIR2DL4, CD158d(human)

HLA-G, SHP2, SHP1(-) IGx2/TM/ITIM

19q13.4

NK, CD30


KIR2DL5 (human)


IGx2/TM/ITIM

19q13.4

NK


KIR3DL1, NKAT3, NKB1, CD158e (human)


IGx2/TM/ITIM

19q13.4

NK


KIR3DL2, NKAT4, CD158z (human)

HLA-A IGx2/TM/ITIM

19q13.4

NK


KIR3DL7 (human)





19q13.42

NK


KIR2DS1, CD158H (human)

HLA-C2,4,5,6, Syk, ZAP70 IGx2/ITAM

19q13.4

NK


KIR2DS2, NKAT5, CD158J (human)

HLA-B, C


19q13.4

NK


KIR2DS3, NKAT7  (human)





19q13.4

NK


KIR2DS4, NFAT8, CD158G (human)

HLA-C4


19q13.4

NK


KIR2DS5, NFAT9, CD158G (human)





19q13.4

NK


KIR2DS6, KIRX, CD158C (human)











KIR3DS1, NKAT4, CD158k (human)


IGx2/ITAM

19q13.4

NK


KIR3DL2 (human)





19q13.4

NK


IRTA1 (human)


IGx4/IM/ITIM

1q21




IRTA2, BXMAS1 (human)


IGx9/TM/ITIM

1q21

B


FCRH3 (human)


IGx4/IM/ITIM

1q21.2-q22



NCR LY95, NKp44, NCR2 (human)

HA, CD3zeta, DAP12, IG/TM

6p21.1 IL2



LY94, NKp46 (human)

HA, HN IGx2/TM

19q13.42 Mt, camptothecin,
NK


LY117, NKp30, 1C7 (human)

viral proteins IG

6p21.3

NK, (T, B)

Butyrophilin
 Butyrophilin A1, BTN1A1 (human, mouse)


IG/TM/SPRY(ZF) 1
6p22-p21.3

 fat droplets in the milk

BTN2A1, BTF1 (human)


IGx3

6p22.1

T, NK, B

BTF1, BT2.1, BTN2A2 (human)





6p22.1

 

BTN2A3 (human)





6p22.1



BTF5, BT3.1, BTN3A1 (human)





6p22.1

T, NK

BTF4, BT3.2, BTN3A2 (human)





6p22.1

T, NK, (B)

Butyrophilin 3, BTN3A3 (human)





6p21.3 dsRNA
NK, T, (B)

Butyrophilin 2, BTNL2, BTL-II, HSBLMHC1 (human)





6p21.3 A2aR
sarcoidosis

BTNL3 , BTNLR (human)


IG/TM/PRY/SPRY

5q35.3



BTNL8 (human)





5q35.3

PBL

BTNL9 (human)





5q35.3

PBL

a1B a1B-glycoprotein, A1B, ABG, GAB, A1BG (human, rat)

CRISP3 IGx5

19cen-q13.2

Liver

beta-2-microglobulin B2M (human, mouse, rat)

CD1s
 IG L
15q21-q22 NF-kB, GR, IRF1, TNFa, IL1, LPS, IFNg, IL1b/IFNg, MDV, HCV, IKKs


MHC-I HLA-A(human),B-L mediate mediate TCR, antigen, MIR MHCI/IG/TM L
6p21.3 AP1, NF-kB, Ets1, TNFa, TRAIL, RANKL, Fas, IL1, IFNs, CREB, PLZF, CBP, p300, PCAF, BRG1, CIITA, RA, IL1b/IFNg, LPS, hsp65, Hp, Hf, Sd, dsDNA, dsRNA, MDV, EV71, hypoxia, CSV-B3, HNF4a, IKKs, ALK1, TGFR1, calcineurin, T3, androgen, HHT L targets


FcRn, FCGRT (human)

B2M, IgG MHCI/IG/TM

19q13.3 IFNa, calcineurin 1 APCs, liver, passive immunity by milk

MHC-II HLA-DMa(human), b, DNa,DOa, DPa1, DPa2, DPb1, DPb2, DQa1, DQa2, DQb1-3, DRa, DRb1-9  mediate/inhibit mediate TCR, antigen, CD1d MHCII/IG/TM L
6p21.3 RFX5, RFX1, RFXAP, RFXANK, CIITA,NF-Y, CREB, Oct1, C/EBPa, AP1, AIRE, c-Myc, NF-IL6, STAT3, Stat4, ARNT2, TAF1, HDAC1, IFNg, IL1b/IFNg, GM-CSF, TNFa, Fas, CD40L, CD3/CD28, IL12, IL15, jagged-1, IL10, GM-CSF, insulin, IGF-II, LPS, hsp65, MDP, Hp, Hf, Sd, CpG, dsDNA, dsRNA, HCV, EBV, EV71, VLP, PTEN, Lyn, A2aR, TIMP1, triptolide, estrogen, androgen, RA, camptothecin L APCs, B,
targets

MIC MICA (human), mouse (RAEI, H60)

NKG2D MHCI/IG/TM

6p21.3 stress, IFNg, IL15
epithelial


MICB (human)

NKG2D MHCI/IG/TM

6p21.3 stress, IFNg, IL15
epithelial


CD74, HLA gamma, invariant chain (human),mouse, rat, horse, bovine,


CD74 1
5q32 androgen, HCV, Lyn, TIMP1
B, DC


CD92, CDw92, CTL1 (human)


CD74/DUF580

9q31.2


Tandem gene information:
mouse MHC; I(K), II{A(Ab, Aa),E(Eb, Ea)}, III{S(C4, Bf, C2, TNF)}, I{D(D,L), Qa(Q1, Q2...), T1a(T1, T2...)}, M(M1,..., NM7)
human HLA 6p21.3; II/D(DPB, DPA, DQB, DQB, DRB, DRA), III(C4B, C4A, Bf, C2, TNF), I (B, C, E, A, H, G, F)
19q13.42 loci of LIR/KIRs/NALPs; , LIRLRB3, LIRLRB5, LIRLRB2, LILRA3, (tweeny), LILRA2, LILRA1, LILRB1, ILT10, KIR2DS4, KIR2DL1, KIR2DL2, Fc alpha R, KIR2DL4, NK-p46, Pypaf3, Nalp2

Adhesion, Anchoring, Transcytosis, Anti-Adhesion Molecules, NKRs and Related Proteins
Group Protein apoptosis Species
locus
 KO 3D binding partner structure TFs upstream regulators memo
CAM ALCAM, MEMD, CD166
human, mouse, rat, dog, chicken 3q13.1-q13.2

CD6 IGx5/TM
RANTES, LPS, IL3, M-CSF, GM-CSF, Blimp1

CD22, LEU14, BL-CAM, SIGLEC2
promote
 human, mouse 19q13.1 L
sialylated staffs, CD45, AP50, SHIP1/Grb2/Shc IGx7/TM
IL1b, Fas, BCR,  Lyn, LPS, GR, IKKg B vs B

MAG, SIGLEC4A
human, mouse
 19q13.1

sialosides IGx4/TM
DEX, cAMP
 brain

LU, BCAM
human 19q13.2


IGx5/TM



nephrin, Nphs1
human 19q13.1 1

IGx8/FN3/TM



CD33, SIGLEC3 induce
 human 19q13.3-q13.4 1
sialosides

SDF1, Lm
 APCs

SIGLEC5, CD33L2, OBBP2
human 19q13.3

sialosides IGx3/TM

bm

Nr-CAM, Bravo, NRCAM
human, mouse, rat, chicken 7q31.1-q31.2

contactin/F11, neurofascin,  RPTPb, axonin-1 IGx6/FN3x3/TM LEF-1 IL1a, b-catenin, Wnt brain

DDM36, NOPE
human 15q22.2







neogenin, NEO1
human 15q22.3-q23


IGx6/FN3x6/TM Pax6


PUNC
human 15q22.3-q23 1

IGx4/FN3x2/TM



MYBPC3
human 11p11.2


IGx6/FN3x2/IG/FN3/IG

heart

MYBPC2, fast
human 19q13.33


IGx5/FN3x2/IG/FN3/IG

heart, tongue

MYBPC1, slow
human 12q23.3


IGx5/FN3x2/IG/FN3/IG

skeletal muscle, tongue

contactin 1, CNTN1
human, mouse, rat, bovine, chicken,zebrafish 12q11-q12 1
tenascin, Fyn, RPTPbeta, Caspr,  NF155, Na+ channel IGx6/FN3x4
St PhoP brain

contactin 2, CNTN2, TAX1, TAG1, axonin 1
human, rat, chicken, zebrafish 1q32.1 1

IGx6/FN3x4

brain

neurofascin, NFASC
human, rat, 1q32.1

contactin, Na+ channel,  Nr-CAM, syntenin-1, ankyrin
 IGx6/FN3x3/TM



IGSF9, Nrt1
human 1q22-q23


IGx4/FN3x2/TM



L1CAM, MIC5, MASA, SPG1, HSAS1, N-CAML1 CAML1, CD171
human, mouse, rat,
 Xq28 1

IGx6/FN3x4/TM Pax6
brain

contactin 5, NB2, CNTN5
human, rat 11q21-q22.2







contactin 3, CNTN3, NIG1, PANG
human, mouse, rat 3p26







contactin 4, BIG2, CNTN4, Axcam
human, mouse, rat, 3p26-p25


IGx6/FN3x4



contactin 6, NB3, CNTN6
human, mouse, rat 3p26-p25


IGx6/FN3



CALL, L1CAM2, CHL1
mediate?
 human 3p26.1


IGx6/FN3x4/TM

brain

ROBO1, roundabout 1
human 3p12


IGx5/FN3x2 TNFa


ROBO4
human 11q24.2


IGx2/FN3x2



BOC
human 3q13.2


IGx4/FN3x3/TM



JAM3
human, mouse 11q25







JAM2, VEJAM
human, mouse 21q21.2







DSCAM, CHD2-42, CHD2-52
human 21q22.2


IGx9/FN3x2/IG/FN2/TM



NCAM2
human 21q21.1


IGx5/FN3x2/TM
EV71

NCAM1, CD56
human, mouse, rat, bovine, chicken, Xl, zebrafish 11q23.1 L 1 prion IGx5/FN3x2/TM NF-kB, Phox2, HOXC6, Hoxc8, Alx4, LEF-1, PLZF, OTX2, Cux-2?, Barx1, p73 TGFb, BMP2, AMPA-R, D2R NK

CDON, CDO, ORCAM
human 11q23-q24


IGx5/FN3x3/TM



DSCAML1, KIAA1132
human 11q23


IGx9/FN3x4/IG/FNx2/TM



SDK2, sidekick 2
human 17q25.2


IGx3/FN3x5/TM



DCC, CRC18, CRCR1
induce
 human 18q21.3 1

IGx4/FNx6/TM



VCAM1, CD106
inhibit
 human, mouse, rat, pig 1p32-p31 1 L integrins, CD29 IGx6/TM NF-kB, Egr1, AP-1, IRF1, IRF2, GATAs, Sp1,PPARa, IL1, TNFa, LTa,dsRNA, IFNs,AngII, IL4, IL5, IL18, PKR, LDL, thrombin, C5a, Resistin, NO, RA, estrogens, glucocorticoids, UTP, LPS, BLP, Ct, Hp, Mt, Pc, ApoE, tax, osmolarity, P2Y2, p38, BMP2, IL10, ALA

ICAM1, CD54 inhibit/(-)/mediate human, mouse, rat, pig, sheep, bovine 19p13.3-p13.2 L L LFA-1, rhinoviruses, CD11, CD43, MIR IGx5/TM NF-kB, p53, c-Myc, EGR1, DLX-7, HOXD10, PDX1
 IL1, IL5, IL6, IL18, TNFa, LTa, TRAIL, Fas, IFNa, PMA, CD3/28, BCR, C4BP, histamine, C5a, ML-1, LPS, BLP, LTA, MDP, OX-CA, LeIF, hsp65, Bm, Cp, Ct, Ld, Lm, Ma, Mt, Pc, St, Tg, CMV(IE2, pp70), MV, HHV8, oxidative stress, irrrad, hypoxia, IFNg, RA, glucocorticoid, p38, PKCd, Src, Nef, IL1b/TNFa, heat shock, PGE2., IL10

ICAM3, CD50
mediate
 human, bovine 19p13.3-p13.2

LFA-1, CD11, CD209 IGx4/TM
IFNa B, T, APCs

ICAM4
human 19p13.2-cen

LFA-1 IGx2/TM



ICAM5, TLCN, TLN
human, mouse 19p13.2


IGx7/TM



PECAM1, CD31
inhibit
 human, mouse, bovine, pig, 17q23 L
CD38, Fyn, Lyn, Src, Yes, Hck, SHP1, SHP2, alphavbeta3 integrin, IGx5/TM/ITIM NF-kB, Egr1 TNFa, Fas, IFNa, IFNg, PMA, camptothecin APCs

ICAM2, CD102
inhibit
 human, mouse 17q23-q25 1 1 LFA1, CD11b/CD18, CD209 IGx2/TM GATA2, TNFa, IL1, VEGF, Cp, Yp, ALK1

TCAM1
mouse, rat






testis

CMRF35
human 17q22-q24


IG/TM
Fas, camptothecin monocyte

CMRF35H9, IRC1
human 17q22-q24


IG/TM

NK, APCs

TREM4, LOC146894
human 17q21.31


IG/TM



NKIR
human 17q25.2


IG/TM



TACTILE
human 3q13.2


IGx3/TM

T, NK

LAMP, LSAMP
human 3q13.2-q21


IGx3/TM



IGSF10,  CMF608, FLJ25972
human 3q25.1


IGx7



MAdCAM1
human, mouse, rat 19p13.3
L CD29 IG NKX2.3 Hp, b-catenin

CEA, CEACAM5, CD66e
inhibit
 human 19q13.2


IG x7 c-Myc, PPARg LPS,cisplatin

CD66a, BGP, CEACAM1
(-)/induce
 human 19q13.2
1 Src, SHP1, SHP2, galectin-3 IGx3/TM/ITIM Hoxd10 RA, VEGF

CGM1, CD66d, CEACAM3
induce
 human 19q13.2


IG/TM



CEAL, NCA, CD66c, CEACAM6
inhibit
 human 19q13.2


IG x7
estrogen, As2O3 lung, bm

CEACAM7, CGM2
human 19q13.2


IGx2
RA

CD66b, CD67, CGM6, NLA95, CEACAM8
human 19q13.2

galectin-3 IGx3
hemin, PACAP

PSG3
human 19q13.2


IGx4

placenta

PSG8
human 19q13.2





placenta

PSG10
human 19q13.2





placenta

PSG1
human 19q13.2





placenta

PSG6
human 19q13.2





placenta

PSG7
human 19q13.2





placenta

PSG11
human 19q13.2





placenta

PSG2
human 19q13.2





placenta

PSG5
human 19q13.2



Sp1
placenta

PSG4
human 19q13.2





placenta

PSG9
human 19q13.2





placenta

TSLL2
human 19q13.32


IGx3/TM/4.1m



SIGLEC7
human 19q13.3
1
 sialic acid,  disialogangliosides, sialosides IGx3/TM
Fas, camptothecin NK, APCs

SIGLEC8, SAF2
human 19q13.33-q13.41

sialosides IGx3/TM



SIGLEC9
human 19q13.41

sialosides




SIGLEC10
human 19q13.3


IGx4/TM

B, NK

SIGLEC11
human 19q13.33


IGx4/TM

adrenal gland

SIGLECL1
human 19q13.4


IGx4/TM



OSCAR
human 19q13.42


IGx2/TM PU.1


PVR, PVS, CD155
mediate
 human 19q13.2-q13.3 mt
PV, vitronectin, Tctex-1
NRF1, GLI1, GLI3 Shh, CMV

basigin, BSG, TCSF, EMMPRIN, CD147
human, mouse, rat, chicken, zebrafish
 19p13.3 L
basigin, MCT1, MCT4
 IGx2/TM Stat4b TSH
 bm

SDFR1, gp65, gp55
human 15q22


IGx2/TM

brain

embigin, gp70IC
human, mouse, rat 5q11.2


IGx2/TM

bm

MGC71745
human
 5q11.2


IGx2/TM

NK, B, T,  APCs

sialoadhesin, SN, CD169, SIGLEC1
human 20p13
L
 sialic acid, sialosides IGx17/TM
IL-4, IFNb, IFNg, LPS
 bm

NEPH1, KIRREL
human
 1q21-q25


IGx4/TM



NEPH2, Kirre, SST4
human 11q24


IGx5/TM



MCAM, MUC18, CD146
human 11q23.3


IGx5/TM AP2 TNFa, IL1, hCG, PMA, cAMP

SYNCAM, TSLC1, BL2, ST17, IGSF4
human 11q23.2


IGx3/TM/4.1m



HVEC, PVRR1, PRR, nectin 1, PVRL1
human 11q23-q24 1
afadin, HSV IGx3/TM
Ma, Fas, camptothecin

nectin 2, Pvrl2, CD112, HVEB, PVR, PVS
human, mouse 19q13.2-q13.4 1

IGx3/TM



PVRL3, PPR3, PRR3, PVRR3, nectin-3,
human
 3q13

afadin

placenta

CD47, IAP
mediate
 human, mouse, rat, bovine, viruses 3q13.1-q13.2 L
SIRPs, alpha v beta 3 vitronectin, Rh, SHPS1 IG/TMx5
Yp, MVA, EV71, TNF, IL1, GM-CSF, NIP3, SDF1

CD200R, OX2R, MOX2R
human 3q13.2

CD200 IGx2/TM



CD200, OX2, MOX2
human 3q12-q13 1
CD200R IGx2/TM


CAM(IG) SNS, CG33141
Dm, Ag



IGx9/FN3/TM



CG8964
Dm







Tandem gene information:
19q13.2- 19q13.31; CEACAM1, CEACAM8, PSG3, PSG1, PSG6, PSG7, PSG11, PSG2, PSG5, PSG4, PSG9, PSG5, PSG4
 
Group Protein apoptosis Species
locus
 KO 3D binding partner structure TFs upstream regulators memo
CD2 CD48
inhibit
 human, mouse, rat 1q21.3-q22

heparan sulfate, CD2, 2B4, Lck, CD2BP1, Lyn, Fyn IG/TM PLZF Yp, EBV, G-CSF, IL13, TRAF2/TRAF5
 B, T, NK, APCs

BY55, CD160
human 1q21.1

MHC-I IG/GDI
TCR
 NK

IGSF4B, NECL1, TSLL1
human 1q21.2-q22


IGx2/TM/4.1m

brain

LFA3, CD58
inhibit
 human 1p13
1 CD2 IG/TM p53 IL2, LPS, RA, DEX

AD026
human 1p12


IG



CD2
induce
 human, hourse, 1p13.1 1
 L CD48, CD2BP1, CIN85, CMS IGx2/TM
Ma, PTH, Notch T, NK

CD84
human 1q24

CD2 family members,
SHP2, SAP		 IGx2/TM
D3 T

SLAM, CD150
human, mouse 1q22-q23

SAP IGx2/TM GR, STAT3 IL1, IL10, PMA,BCR, LPS, Hp Thy

Ly9, CD229
human, mouse 1q21.3-q22

SAP, CD48, AP-2 IGx2/TM AIRE
T, DC

2B4, CD244, Nmrk
human, mouse,rat 1q23.1 1
CD48 IGx2/TM
Rac2, TCR
 NK

BLAME
human 1q22


IGx2/TM



SLAMF6, NTBA, KALI
human 1q22

SHP1, SHP2, SAP IGx2/TM/(TxYxxV/I)x2/ITIM



LNIR, PRR4, PVRL4
human 1q22-q23.2


IGx3/TM



SLAMF7, 19A24, CRACC, CD1
human 1q23-q24


IG/TM

DC, NK

SLAMF9, CD84-H1
human 1q22


IG/TM



F11R, JAM1, PAM-1
human, mouse, rat, bovine 1q21.2-q21.3
1 LFA1 IGx2/TM
IL5 epithelial

FGFRL1
human, mouse
 4p16


IGx3/TM



IGSF4D, NECL3
human, mouse
 3p12.2


IGx3/TM/4.1m

brain
CD83 CD83
human, mouse, rat 6p23 1
sialic acid
 IG/TM NF-kB TNFa, CD40L, IFNg, CD38, IL4, PA, LPS, KF1B, Hp, Ld, Lm, Mt, Sm, Tg, Ye, LMP1, PMA, D3, Blimp1, TIMP1 B, APCs
TIM HAVCR, TIM1
human, mouse 5q33.2

HAV IG/Muc/TM



TIM2, Timd2
mouse


SEMA4A IG/Muc/TM
blastcysts

HAVCR2, TIM3
human, mouse 5q33.3 1

IG/Muc/TM

NK, Th1

TIM4, LOC91937
human, mouse 5q33.3


IG/Muc/TM


other pIgR
human, mouse, rat, rabbit, bovine 1q31-q41 1
IgA, CbpA, CaM, IGx5/TM IRF1, NF-kB, STAT6 IFNg, IL4, TNFa, androgen trtachea, IgA transport

FKSG87, Fcalpha/muR
human 1q31.3

IgA, IgM IG/?
IL1

Toso
inhibit
 human, mouse, rat 1q31.3

FADD
 IG/TM
IL2, TCR, Hp B, T, NK

kilon, MGC46680
human 1p31.1


IGx3



myopalladin, MYPN
human 10q22.1


IGx5



CNAIP, NFAM1
human, mouse 22q13.2


IG/TM/ITAM

kidney

MDGA1
human 6p21


IGx6/FN3/MAM/GPI



Thy-1, CD90
induce
 human 11q23.3

Mac1
 IG
Yp brain

neurotrimin, HNT
human 11q25


IGx3/GPI



OBCAM, OPCML
human 11q25


IGx3

(brain)

DKFZp566D234
human 4q32.3


KAZAL/EF/IGx2



palladin, CGI151
human 4q32.3

ezrin (FPPPP)/IGx5



myotilin, TTID
human 5q31


?/IGx2

skeltal muscle, tongue

FLJ20674
human 12q24.23


IGx3/TM



SIRPa1, SHPS1, MYD1, MFR, PTPNS1
(promote)
 human 20p13

SHP1 UGx2/TM/ITIM



IGSF1, IGDC1
human Xq25


IGx5/TMx2/IGx6

pituitary

WFIKKNRP
human 17q21.33


WAP/KAZAL/IG/KUx2/C345C



perlecan,  HSPG2, PLC, SJA, SJS, SJS1
human, mouse 1p36.1-p35


SEA/LDLax4/IG/LamB/EGFx3/LamB/EGFx4/LamB/EGFx3/IGx21/LamG/EGFx2/LamG/EGFx2/LamG
TGFb, NO adipocyte, s.muscle, cardiac

hemicentin, fibulin 6, FIBL-6
human 1q25.3


WVA/IGx3/TSP1x6/G2F/EGFx8



hemicentin-2
human 9q34.2







titin
human 2q24.3


huge!

skeletal muscle
LRR/IG LRIG2, KIAA0806
human 1p13.1


LRRs/IGx3/TM



GAC1, LRRN2
human, mouse, rat, 1q32.1


LRRs/IG/TM

brain

LRRN3, NLRR3
human 7q31.1


LRRs/IG/TM
IL12, TGFb T, brain

FLJ31810
human, mouse, rat 9p21.1-p13.3


LRRs/IG/TM

brain

LERN1, UNQ201,, FLJ14594
human, mouse, rat, 15q24.1


LRRs/IG

(brain)

LRRN1
human, mouse, frog 3p26.2


LRR/IG/FN3/TM

T

LRRN3
human, mouse, rat 7q21.12


LRR/IG/FN3/TM

T, brain

LIG1, LRIG1
human 3p14


LRRs/IGx3/TM



FLJ90440
human 12q13.2


LRRs/IGx4/TM



PAL
human 10q23


LRRs/IG/FN3/TM



adlican
human Xp22.33


LRRs/IGx2/?/IGx10

adrenal
Group Protein apoptosis Species
locus
 KO 3D binding partner structure TFs upstream regulators memo
SRCR CD6
inhibit
 human, mouse, rat 11q13

CD166 SR x3/TM
PMA, Yp, D3 T

CD5, Leu1, Ly1
mediate
 human, mouse, rat, sheep, chicken, 11q13 1
CD72 SR x3/TM/ITIM NFATs, E47, Ets1 TNFa, TCR, PMA, IgM, IFNa, Yp, PKCs, androgen T

DMBT1, gp340
human 10q25.3-q26.1

SFTPD SRx13/CUB/SR/CUB/ZP

trachea

see also CD160, M160





SRs


cadherin BR-cadherin, N-cadherin 2, CDH12
human, mouse 5p14-p13





B

K-cadherin, CDH6
human, mouse, rat, chicken, Xl 5p15.1-p14







cadherin 18, CDH18 (formerly CDH14)
human, rat 5p15.2-p15.1





brain

LI-cadherin, CDH17
human, mouse, rat 8q22.1


Cad.R x6/TM Cdx2
 Sd, Sp pancreas

E-cadherin, cadherin-1, CDH1 inhibit/promote human, mouse, chicken, zebrafish 16q22.1 L L cytoskeletal proteins Cad.R. x5/Cad/TM/Cad-C  Snail, WT1, E12/E47, SIP1, Rb, c-Myc, AP-2, TGFb, DNA methylase, PS1, ET-1, LMP1, PMA

OB-cadherin, CDH11
human, mouse, chicken 16q22.1




PDGF s.muscle, cardiac, adipocyte

P-cadherin, cadherin-3, CDH3
human, bovine, pig 16q22.1 L
cytoskeletal proteins Cad.R. x5/ Cad/ TM/ Cad-C
ErbB2, ARNT2

VE-cadherin, CDH5, CD144
inhibit
 human, mouse, pig 16q22.1 1
b-catenin, p120CAS Cad.R. x5/ Cad/ TM/ Cad-C Sp1, Sp3, Erg, Ets1, Egr1, RANKL lung, placenta

cadherin 8, CDH8
human, mouse, rat 16q21-q22.1







KSP-cadherin, CDH16
human 16q22.1





kidney

M-cadherin, cadherin-15, CDH15
human, mouse 16q24.3




MVA, Pg

T-cadherin, cadherin 13, CDH13
human, mouse, rat, chicken 16q24.2-q24.3


Cad.R x5 NF-kB TNFa, IKKs, irrad

T1-cadherin, CDH9
human 5p14







T2-cadherin, CDH10
human, chicken 5p14-p13





brain

BH-cadherin, PCDH7, BHPCDH
human, chicken 4p15

PP1a Cad.R x7/TM NF-kB TNFa, IL1, IKKs

R-cadherin, cadherin-4, CDH4
human, mouse, rat 20q13.3





brain

PB-cadherin, CDH22
human, mouse, rat 20q13.1




PTH brain

VR20, CDH26
human 20q13.2-q13.33





epithelium

N-cadherin, cadherin-2, CDH2
inhibit
 human, mouse, bovine, chicken, zebrafish 18q11.2 L L cytoskeletal proteins Cad.R. x5/ Cad/ TM /Cad-C MyoD Rac2 s. muscle, cardiac

cadherin 7, CDH7
human, chicken 18q22-q23







cadherin 19, CDH19 (formerly CDH7)
human 18q22-q23





DRG

cadherin 20, CDH20
human, mouse 18q22-q23







desmocollin 1, DSC1
human, mouse 18q12.1 1

Cadx5/TM NF-IL6
skin, desmosome

desmocollin 2, DSC2
human, mouse 18q12.1





tongue, epithelium

desmocollin 3, DSC3
human, mouse, bovine 18q12.1




TNFa epithelium, tongue, skin

desmoglein 1, DSG1
human, bovine 18q12.1


Cadx5/CAD-C

skin, tongue

desmoglein 2, DSG2
human, mouse 18q12.1





epithelium

desmoglein 3, PVA, DSG3
human, mouse 18q12.1-q12.2 1




epithelium, tongue, tonsil

desmoglein 4, DSG4
human 18q12.1







PCDH10
human 4q28.3





brain

PCDH15
human 10q21.1 av






PCDH18
human 4

Disabled-1


adipocyte

FAT
human 4q34-q35


Cadx34/EGF/LamininG/EGFx4/TM

epithelium

FAT2, MEGF1
human, rat 5q32-q33





cerebellum

otocadherin, CDH23
human, mouse,rat 10q21-q22 mt






 
group name apoptosis species locus KO 3D binding partner structure TFs upstream regulators memo
protocadherin alpha 1, PCDHA1
human 5q31





brain

PCDHA2
human 5q31





brain

PCDHA3
human 5q31





brain

PCDHA4
human 5q31





brain

PCDHA5
human 5q31





brain

PCDHA6
human 5q31





brain

PCDHA7
human 5q31





brain

PCDHA8
human 5q31





brain

PCDHA9
human 5q31




IL1
 brain

PCDHA10
human 5q31





brain

PCDHA11
human 5q31





brain

PCDHA12
human 5q31





brain

PCDHA13
human 5q31




TNFa
 brain

PCDHB1
human 5q31







PCDHB2
human 5q31







PCDHB3
human, mouse 5q31







PCDHB4
human, mouse 5q31







PCDHB5
human, mouse 5q31







PCDHB6
human, mouse 5q31







PCDHB7
human, mouse 5q31







PCDHB8
human 5q31







PCDHB9
human 5q31







PCDHB10
human 5q31







PCDHB11
human 5q31







PCDHB12
human 5q31







PCDHB13
human, mouse 5q31







PCDHB14
human, mouse 5q31







PCDHB15
human, mouse 5q31







PCDHB16
human, mouse 5q31







Pcdhb22
mouse








protocadherin gamma A1, PCDHGA1
human, mouse 5q31





brain

PCDHGA3
human, mouse 5q31





brain

PCDHGA4
human 5q31





brain

PCDHGA5
human 5q31





brain

PCDHGA6
human 5q31





brain

PCDHGA7
human 5q31





brain

PCDHGA8
human, mouse 5q31





brain

PCDHGA9
human, mouse 5q31





brain

PCDHGA10