Index | Caspase | CARD/DED/BIR | Bcl-2 | DD | TNF/TNFR | Kinases | ILs | Viral | Lipid | Engulf | TF | RING | Toll | Other Apop | Other NFkB | Alphabet |
Proteins for Immunity
TLRs, related protein and non-lectin/Ig type
pathgen
recognizing proteins (Nod family is
here)
Group | Protein | Species | apoptosis |
|
Binding Partner | Structure | KO | gene | locus | regulators | 3D | memo |
TLR |
Toll | D.m.,D.p.,D.s., S.a., A.g. |
|
Tube, MyD88 | LRR/TM/TIR | 1 | 1 | LPS, IL13, PMA | TIR | anti-fungal | ||
TLR1 | human, mouse, sea urchin |
|
(BLP) | LRR/TM/TIR | L | 4p14 | IFNg, influenza A, Sendai, Hp | TIR | anti-bacterial | |||
TLR2 | human, Mf, mouse, bovine, chTLR2(chick), sea urchin |
|
|
MD2,
SP-A,
zymosan,
PGN,
(L
TA, BLP,
LPS(?),
porins,
glycolipid,
hsp70,
hsp60),
TRIF,
MyD88, TRIAD3 |
LRR/TM/TIR | L | 1,2,3 | 4q32 | NF-kB, STAT5, Sp1, Sp3, TLR4, LPS (-), PGN, LTA, Lm, TNFa, Fas, IFNa, IFNg, DEX, GCSF, TCR, PMA, Ec, Sa, influenza A, Sendai | TIR, TIR(P681h) | anti-bacterial |
|
TLR3 | human, mouse, bovine, | (induce?) |
|
(dsRNA,
mRNA),
TRIF,
TRIAD3 |
LRR/TM/TIR | 1 | 4q35 | TRAIL, IFNa/b, IFNg, STAT1, LPS, LTA, dsRNA, B-DNA, Ec, Lm, Sa, LLO, PMA, IFNAR1, TRIF | anti-viral | |||
TLR4 | human, mouse, rat, bovine, dog, cat, chimpanzee, horsebaboon | induce |
|
(LPS,
sHA,
hsp70,
hsp60,
heparan
sulfate proteoglycan), CD14, MD2,
MyD88, TLR5,
BTK,
JIP3, TRIAD3,
NAD(P)H
oxidase |
LRR/TM/TIR | L, d | 1, m | 9q32-q33 | PU.1, AP1, MIF, TNFa, IFNa, IFNg, LPS, LTA, Lm, hypoxia, Oxidant stress, PMA, estrogen, influenza A, Sendai, MIF | anti-Gram negative | ||
TLR5 | human, mouse, trout | flagellin,
TLR4,
TRIAD3 |
LRR/TM/TIR | 1 | 1q41-q42 | Ec, Hp, Lm, Sa, flagellin | anti-bacterial | |||||
TLR6 | human, mouse | (BLP), BTK | LRR/TM/TIR | 1 | 1 | 4p15.1 | PMA, Fas, LPS, LTA, Hp | anti-bacterial |
||||
TLR7 | human, mouse | (ssRNA, imidazoquinolines, R-848, CpG) | LRR/TM/TIR | Xp22.3 | IFNa, IFNg, LPS, LTA, Ec, Sa, influenza A, Sendai, PMA, MeDNA | anti-viral | ||||||
TLR8 | human, mouse | (R-848) | LRR/TM/TIR | Xp22 | LPS, PMA | |||||||
TLR9, CpG1 | human, mouse, pig, cat, dog, bovine, | (DNA,CpG),
Ras,
BTK,
TRIAD3 |
LRR/TM/TIR | L | 3p21.3 | CSF1, IgG, MeDNA | anti-bacterial | |||||
TLR10 | human | LRR/TM/TIR | 1 | 4p14 | IgG | |||||||
TLR11 | mouse | induce | LRR/TM/TIR | uropathogenic bacteria | ||||||||
TLR12 | mouse | LRR/TM/TIR | ||||||||||
TLR13 | mouse | LRR/TM/TIR | ||||||||||
SIGIRR/TIR8 | human, mouse | inhibit | LRR/TM/TIR | L | 11p15.5 | |||||||
18 wheeler | D.m., Bm | LRR/TM/TIR | 1 | 1 | 2R 56F7-56F8 | anti-bacterial | ||||||
Toll5/Tehao | D.m., D.s. | LRR/TM/TIR | 1 | |||||||||
Toll7/Tollo/Tak1 | D.m. | LRR/TM/TIR | 1 | |||||||||
Toll4/CG18241 | D.m. | LRR/TM/TIR | 1 | 2L | ||||||||
Toll6/CG7250 | D.m. | LRR/TM/TIR | 1 | 3L | ||||||||
CG5528 | D.m. | LRR/TM/TIR | 1 | 3L | ||||||||
Toll7/CG8595 | D.m. | LRR/TM/TIR | 1 | 2R | ||||||||
Toll3/DmMstProx | D.m. | LRR/TM/TIR | 1 | |||||||||
Toll-related (under construction) | grasshopper, mosquito (1, 2, 3, 6, Trex, Toll9),G.p.p. | TIR(partial) | ||||||||||
Tol-1 | C.e. | LRR/TM/TIR | 1 | 1 | I | |||||||
RP105, CD180 | LY64 (human), RP105(mouse) |
|
MD1 | LRR/TM | 5q12 | AIRE, PMA, Ec, Hp, Sa | ||||||
Synleurin | human | LRR/TM | 5q12 | |||||||||
Adaptors |
MyD88 | human (S), mouse, frog, D.m. |
|
|
IRAK,IRAK-2, IRAK-M, IL-1R, FADD, MAL | DD/TIR | L | 1,2p21.3 | 3p21.3 | IL-6,
IRF1, STAT3,
STAT5,
IFNa/b,
IFNg,
IL6,
IL15,
IL21,
TNFa,
TRAIL,
M-CSF,
MDP,
Ec,
Hi, Mt,
Sa,
Ye,
Yp,
LPS,
PMA,
TCDD;
TGFb |
Ub |
|
Tube | D.m. |
|
Pelle, Toll, Cactus | DD | 1 | 1 | Tube/Pelle DD | |||||
TIRAP, MAL | human, mouse |
|
TLR4/MD2, MyD88, IRAK2, MAL | /TIR | L | 1 | 11q24.2 | LPS | ||||
TRIF, TICAM1, LPS2 | human, mouse |
|
|
TLR2,
TLR3,
IRF3,
RIP,
RIP3 |
/TIR/RHIM | L | 19p13.3 | NF-kB, TNFa, IL1, IFNb, PAMPs, Hoxd10 | for TLR3, 4, targets | |||
TIRP, TRAM, TICAM2 | human, mouse |
|
TLR4, TRIF, IL1R, IRAKs, TRAF6 | TIR | 1 | 5q23.1 | ||||||
SARM,
TIR-1
(Ce), CG7915 (Dm) |
human,
mouse,
rat, Ce, Dm,
Ag, |
ARMs/SAMx2/TIR |
17q11 |
|||||||||
Tollip | human, mouse, C.e. |
|
Tom1,
IRAK, IL1R |
C2//CUE | 1 | 11p15.5 | VLP |
Ubiquitination |
||||
Pellino (Pli) |
Dm, Ce | Pelle | ||||||||||
Pellino 1(human, mouse) |
|
IRAK, IRAK4, TRAF6 | 2p13.3 | LPS, TRIF | ||||||||
Pellino 2(human, mouse) | IRAK,
IRAK4,
Bcl10 |
14q21 | AP1 | |||||||||
RNA
helicase |
MDA5, HELICARD |
human,
mouse, |
( IRF3) |
induce |
(polyIC) |
CARD/AAA/helicase |
L |
2p24.3-q24.3 |
IFNb, mezerein, B-DNA | casp,
B, T, APCs |
||
RIG-I, DDX58 |
human,
mouse,
bovine,
pig,
chicken,
fugu, |
induce
(also IRF3) |
induce |
CARD/AAA/helicase | L |
9p12 |
IFNb |
|||||
VISA, IPS1, MAVS, CARDIF |
human,
mouse,
rat, |
induce |
CARD/TM | L |
NS3/4A |
|||||||
Kinase | IRAKs | for IRAK family, see kinase | ||||||||||
ligand? | SPAETZLE | D.m. |
|
Toll | NGF | 1 | 1 | fungi inf. | ||||
HMGB1 | human | induce | HMG | 1 | ||||||||
PGRP |
PGRP-Ialpha,
PGLYRP3 |
human, mouse, rat | PGN | ami2x2 | 1q21 | esophagus, fetal liver | ||||||
PGRP-Ibeta,
PGLYRP4 |
human,
mouse |
PGN | ami2x2 | 1q21 | esophagus | |||||||
PGRP-S,
tag7, PGLYRP, PGLYRP1 |
human, mouse, rat, bovine | PGN | ami2 | 1 | 19q13.2-q13.3 | TCR, Hf, Hp | bone marrow | |||||
PGRP-L,
PGLYRP2 |
human, mouse, pig | PGN | ?/ami2 | 19p13.13 | liver | |||||||
PGRP | D.m. (SA, SB1, SB2, SC1, SC2, SD) | PGN | ami2 | mediate Toll pathway | ||||||||
PGRP related | phage lysozyme,[T7, T3, fYe03-12] bacterial[M.t., S.c., Cg, ] | PGN | ami2 | KAmt, w/RNApol, LB | ||||||||
Lysozyme |
LYZ |
lysozyme, LYZ (human,
mouse
M, P,
rat) |
lysozyme | 12q14.3 | MEF, GABP, RA, LPS, Sp, HCV, NRF2, TNF, TRAF2/TRAF5 | APCs |
||||||
LYZL6, LOC57151 (human) |
lysozyme | 17q11.2 | testis |
|||||||||
SPACA3, LYC3, LYZL3, SLLP1,
ALLP17 (human) |
lysozyme |
17q11.2 |
testis | |||||||||
LYZL4, LYC4 (human) |
lysozyme | 3p22.1 |
testis | |||||||||
LYZL1, LYC2, MGC33408 (human) |
lysozyme | 10p11.23 | testis | |||||||||
LYZL2 (human) |
lysozyme |
10p11.23 |
testis |
|||||||||
PNPK6288, LOC389852 (human) |
lysozyme | Xp11.23 | testis, skin |
|||||||||
lactalbumin alpha, LALBA (human) |
lysozyme | 12q13 | mammary gland |
|||||||||
SLT |
LYG1, LOC129530, SALW1939,
Lysozyme G (human,
mouse,
chicken,
Xl, zebrafish,
Ec) |
SLT |
2q11.2 | tongue | ||||||||
LYG2, LYGH (human,
mouse) |
SLT | 2q11.2 | ||||||||||
Other |
CD14 | CD14 (human, mouse, rat, horse, bovine, rabbit) |
|
mediate | LPS, PGN | LRR-GPI | L, d | 1 | 5q31.1 | AP-1, AIRE, Sp1, MEF2D, PPARg, IFNg, PMA, TGFb1, IL13, LPS, Pg, Hf, C/EBPs, estrogen, PGE2, PMA, cAMP, ethanol | 1 |
anti-bacterial, APCs |
ML |
MD2 (human, mouse, C. hamster, bovine) | TLR4, LPS, LTA, TLR2, MD2 | ML | 1 | 1,2 | 8q13.2 | IFNg, SOCS3, PMA | APCs |
||||
MD1, Ly86 (human, mouse) | RP105, (LPS) | ML | 1 | 1,2 | 6p24.1 | Myb, PMA, Tc | APCs, B |
|||||
Npc2, HE2 (human) | cholesterol | ML | npc | 14q24.3 | AIRE | 1 | ubiquitous, highest in APCs |
|||||
GM2A (human) | GM2 | ML | 1 | 5q31.3-q33.1 | 1 | placenta, bronchia, preB |
||||||
LBP |
LBP (human, mouse, rat) | LPS, PGN |
LBP | L | 20q11.23-q12 | NRF2, RA, A2aR, Pg, Hp | liver |
|||||
BPI (human, rabbit, bovine, Ce, At) | LBP | 20q11.23-q12 | Hp | 1 | neutrophil |
|||||||
BPIL1, RYSR, LPLUNC2 (human) | LBP | 20q11.22 | airway | |||||||||
BPIL3, LPLUNC6 (human) | 20q11.22 | alfactory epithelium |
||||||||||
BPIL2 (human) | LBP | 22q12.3 | epidermis, digits |
|||||||||
PLTP, LTP2 (human, mouse, rabbit, pig,) | LBP | 1 |
20q12-q13.1 | LXR, FXR, hypoxia, bile acid, fenofibrate, ErbB4 | epidermis |
|||||||
LPLUNC1, C20orf114 (human) | 20q11.1 | airway | ||||||||||
RYA3, LPLUNC3,
dJ726C3.4、C20orf185 (human) |
LBP | 20q11.21 |
||||||||||
RY2G5, LPLUNC4, dJ726C3.5,
C20orf186 (human) |
LBP | 20q11.21 |
||||||||||
CETP (human, rabbit) | LBP | 16q21 | lymph node, placenta, liver |
|||||||||
Mindin |
Spondin 2, M-spondin, Mindin, SPON2 (human, mouse) | FS/TSP1 | 1 | 4p16.3 | NK |
|||||||
spondin 1, F-spondin, SPON1 (human, mouse) | FS/TSP1x6 | 11p15.2 | ||||||||||
CCF | earthworms, CG6895-PA(Dm) | beta 1,3-glucanase | ||||||||||
BRICHOS |
SP-C, PSP-C, SFTP2, SP5, SFTPC (human, mouse, rat) | CD14, LPS | BRICHOS | L | 8p21 | TTF1,
GATA6,
TAZ |
lung |
|||||
LECT1, CHM1, CHM-I, BRICD3, Chondromodulin (human, mouse, rabbit, chicken, zebrafish) | BRICHOS | L | 13q14-q21 | Sp3, TGFb, FGF2, PTHRP | ||||||||
ITM2B, BRI, FBD, ABRI, BRI2, E25B, E3-16, BRICD2B (human, mouse, Ce, zebrafish) | BRICHOS | dmt | 13q14.3 | |||||||||
ITM2A, E25A, BRICD2A (human, mouse) | BRICHOS | Xq13.3-Xq21.2 | ||||||||||
tenomodulin, TNMD (human, mouse, rat, | BRICHOS | Xq21.33-q23 | ||||||||||
BRI3, E25, Itm2c (human, mouse, chicken) | BRICHOS | 2q37 | APCs |
|||||||||
GDDR (human) |
BRICHOS | 2p13.3 |
||||||||||
AMP18 (human) | BRICHOS | 2p13.2 | ||||||||||
albumin | albumin, ALB (human) | PG | albumin x3 |
4q11-q13 | C/EBPa, NF-IL6, HNF1, AP1, p53, HGF, HB-EGF, TNFa, DEX, H-Ras | Liver |
||||||
alpha-fetoprotein, AFP (human) |
albumin x3 | 4q11-q13 |
NF-kB,
C/EBPs,
FOXA,
Nkx2.8,
T3R,
p53,
ATBF1,
DEX/GR,
HNF1,
HNF3,
HNF4,
AP1,
RA/RAR/RXR,
TGFb,
HGF,
12-PGJ2,
osmotic
pressure, H-Ras,
Raf,
Rif,
Butyrolactone
I |
fetal liver |
||||||||
apha-albumin, ALB2, ALBA, AFAMIN
(human) |
albumin x3 | 4q11-q13 | liver |
|||||||||
DBP (human) |
albumin x2 | 4q11-q13 | ||||||||||
Serpin | Serpin27A (Dm) | 4q11-q13 |
mediate Toll pathway | |||||||||
C114 | C114, PRKRIP1 (human, mouse, Dm, Ce, Nc) | dsRNA, PKR | cc | 7q22.1 | IL11 |
Ig-related Proteins
Group | Protein | Species | apoptosis |
|
Binding Partner | Structure | KO | gene | locus | regulators | 3D | memo |
IgG sup. | Ig | Kappa (IGKC: ex: human) | 2p12 | NF-kB, ARNT2, TCR/CD3, PMA, TNFa, IL12, IL15, Hp, VDR | ||||||||
Lambda(IGLC1: ex: human) | 22q11.2 | TIMP1 | ||||||||||
heavy (human: const. ex: a1,a2, g1, g2, g3, g4, d, e,) | L | 14q32.33 | LPS, Hp, Sm, IL10/12, estrogen, IL5, Blimp1, Lyn, ARNT2, TIMP1 | |||||||||
TREM1 | TREM1(human, mouse) | inhibit |
DAP12 | IG/TM | 6p21.1 | LPS, fungi | APCs |
|||||
TREM2 (human) | DAP12 |
IG/TM | 1 |
6p21.1 | ||||||||
TLT1 (human) | IG/TM | 6p21.1 | ||||||||||
TREML2, FLJ13693, C6orf76 (human) | IG/TM | 6p21.32 | ||||||||||
RAGE, AGER (human, mouse, rat, bovine) | IGx2/TM | 6p21.3 | IFNa | |||||||||
DAP12 | DAP12, TYROBP (human, b, mouse, pig, cow) |
|
DAP12, CD94, KIR2DS2, TREM1, TREM2, ZAP70, Syk, NKG2D, NKp44 | TM/ITAM | L | 19q13.1 | TCR | NK, DC | ||||
DAP10 (human, mouse, pig) | NKG2D, PI3K | TM | L | 19q13.1 | B, T |
|||||||
TCR | TCRa (ex:human) | induce | activate | antigen, CD3, CD8, SH2s, Lck, TCRb | IG/TM(VJC) | L | 14q11.2 | LEF1, TCF1, CREB, HIV1, TNFa, ALK1 | 1 | T |
||
TCRb (ex:human) | antigen, superantigens, CD3, TCRa | IG/TM(VJC) | 1 | 7q35 | NF-kB,Hp, HCV, | 1 | ||||||
TCRg (ex: human) | TCRd | IG/TM(VJC) | 7p15-p14 | TCR,
IL3,
Mad1 |
||||||||
TCRd (ex:human, mouse, rat, sheep, chicken, Xl) | TCRg | IG/TM(VJC) | 1 | 14q11.2 | T3, IFNa, Notch, PPARa | |||||||
CD3g (human, mouse, rat, bovine, sheep) | induce | activate | TCR | IG/TM/ITAM(AP2) | 1 | 11q23 | SDF1,
Mad1,
Tc, HCV,
camptothecin,
TIMP1 |
T, NK |
||||
CD3e (human, bovine, sheep, dog, chicken) | TCR | 1 | 11q23 | Tc | T |
|||||||
CD3d (human) | TCR | IG/TM/ITAM | 1 | 11q23 | IFNa | T |
||||||
CD3zeta, CD3Z (human, mouse,chick) | Syk, ZAP70, NKp46 | TM/ITAMx3 | 1 | 1q22-q23 | O2 stress, PMA, PPARa | NK, T |
||||||
CD79 | CD79A, mb1, Ig-alpha (human, mouse) | Ig/CD5/CD19/CD22/CD79b | IG/TM/ITAM | 1 | 19q13.2 | Pax5,
TIMP1 |
B | |||||
B29, CD79B, Ig-beta (human, rat) | Ig/CD5/CD19/CD22/CD79a | IG/TM/ITAM | 17q23 | EBF, OBF1, GR, c-Myc, UVB, Lyn, TIMP1 | B |
|||||||
CD8 | CD8alpha, Lyt23 (human, mouse, rat, chick) | induce/ inhibit | activate | MHC-I, Lck | IG/TM | L | 2p12 | ,ITM2A, CREB, HIV1, VLP, Ikaros | L | T, NK, for MHC-I | ||
CD8beta, CD8B1 (human, mouse, rat, chick) | Ig/TM | 1 | 2p12 | CsA/FK506, IL15, LiCl, MVA | T |
|||||||
CD4 | CD4, L3T4 (human,mouse, rat, chick) |
|
activate | MHCII, TCR, LCK | IGx3/TM | L | 12pter-p12 | c-Myb, Elf1, Ets1,Ets2, MAZ, ZEB, HES1, TCR, PMA, HHV6, HHV7, HBx | APCs, for MHC-II | |||
IgE Fc R, FceRI | IgE Fc R a, FCER1A (human, mouse, rat) | IGx2/TM | 1q23 | STAT6, IL4, GATA1, Elf1, USFs, GCSF, BMP2 | 1 | APCs |
||||||
IgE Fc R g, FCER1G(human, mouse, rat) | TM/ITAM | 1 | 1q23 | TCR, Tc | APCs, NK |
|||||||
IgG Fc gamma R | IgG Fc R 1, FCGR1A, IGFR1, CD64 (human) | high affinity for Fc g, periplakin | IGx3/TM | L | 1q21.2-q21.3 | IFNa,
IFNg,
IL1,
LPS,
Tc, D3,
estrogen |
||||||
IgG Fc RII, FCGR2A, IGFR2, CD32 (human) |
|
induce | low affinity for Fc g | IGx2/TM | L | 1q21-q23 | LPS, IL8, IL10, SCF, DEX, hypoxemia | APCs | ||||
IgG Fc RIII, FCGR3A, IGFR3, CD16 (human a, b) | low affinity for Fc g | IGx2/TM | L | 1q23 | IFNg,
IL2,
IL3,
IL8,
HCV,
ARNT2,
IFNa,
staurosporine |
NK |
||||||
Fc alpha R | Fc alpha R, IgA Fc R, CD89, FcaR (human) | IGx2 | 19q13.2-q13.4 | C/EBPa, Fas, Elf-1, camptothecin | APCs, Eo |
|||||||
CD7 | CD7 (human, mouse) |
|
CD3, CD45, PI3K, | IG/TM/YEDM | 1 | 17q25.2-q25.3 | Notch,
Ca2+,
cAMP,
IL5 |
NK, T |
||||
CD19 | CD19 (human, mouse, pig) |
|
mediate | CD2, CD9, , CD81, CD225, Lyn, c-Abl, PI3K | IGx2/TM | L | 16p11.2 | Pax5, Lyn(P), CD81 | B cell, RP105 | |||
B7 | CD80, CD28LG1, B7-1 (human, mouse, rat) |
|
CD28, CTLA4 | IGx2/TM | L | 3q21 | NF-kB, Bcl6, HLX, TCR/CD3, IL1, IL4, IL10, jagged-1, GM-CSF, TNFa, Fas, IFNb, IFNg, Hp, Yp, dsDNA, HIV Vpr, MVA, S-27609, LeIF, triptolide | L | ||||
CD86, CD28LG2, B7-2 (human, mouse, rat) |
|
CD28, CTLA4, MIR | IG/TM | L | 3q21 | NF-kB, ARNT2, BCR, IFNb,IFNg, TNFa/IFNg, CD40L, C4BP, LPS, MDP, S-27609, Hp, Lm, Tc, UDP-Glc, IL-3, IL10, IL18, GM-CSF, jagged-1, Jnk, p38, DEX, D3, PGE2, triptolide, estrogen, camptothecin | APCs |
|||||
GL50, B7H2, B7RP1, ICOSL, LICOS(human, mouse) | ICOS | IGx2/TM | L | 21q22.3 | A2aR | 1 | ||||||
B7H1, PD-1 ligand, PD-L1 (human, mouse) | PD-1 | IGx2/TM | 1 |
9p24 | TNFa,
IFNg,
LPS,
Hp,
Sm, STAT1,
TLR4,dsRNA,
B-DNA |
|||||||
PDL2, B7-DC (human, mouse) | 9p24.2 | IL4, IFNg, LPS, Ag, Sm, STAT6, | ||||||||||
B7H3(human, mouse), 4Ig-B7-H3 (human) | (IGx4+)IGx2/TM | L | 15q23-q24 | PMA/Io, Inf.cyt. | IFNg | |||||||
B7-H4, B7S1, B7x (human, mouse, rat) |
|
BTLA | IGx2/GPI | 1p11.1 | ||||||||
CD28 | CD28, Tp44(human, mouse, rat,chick) |
|
activate | B7 family | IG/TM | L | 2q33-q34 | TNFa, TCR, Mt, MVA, Subst.P | T, targets, IL2, CD30, AP-1 ,NF-ATp | |||
CTLA4, CD152(human, mouse, rat) |
|
supress | IG/TM | L | 2q33 | Tprim., OX40, AIRE | L | T |
||||
ICOS/AILIM(human) | prevent | IG/TM | L | 2q33 | TNFa,
LPS,
IL4,
IL12,
IL23 |
|||||||
PD-1, PDCD1 (human, mouse) | involved? | PDL1, SHP2 | IG/TM/ITIM | L | 2q37.3 | Pax5, Egr1, Nur77 | ||||||
BTLA (human) | B7H4, SHP1, SHP2 | IG/TM/ITIM | 3q13.2 | B |
||||||||
CD1 | CD1a (human, pig, horse) | glycolipid, B2M | IG/TM | 1q22-q23 | GM-CSF, Hp, MVA | Thy |
||||||
CD1b (human, rabbit, sheep b1, b2, b3, guinea pig b1, b2, b3, b4, horse) | glycolipid, B2M | IG/TM | 1q22-q23 | VEGF,
IL13 |
L | Thy |
||||||
CD1c (human, guinea pig c1, c2, c3) | glycolipid, , B2M | IG/TM | 1q22-q23 | IL13 | Thy, APCs, B |
|||||||
CD1d (human, mouse d1, d2, rat d1, d2, sheep) | glycolipid, B2M, MHCII, gp180 | IG/TM | L | 1q22-q23 | Sp1,
IL13,
LPS,
hsp65,
androgen,
D3 |
APCs |
||||||
CD1e (human, monkey, rabbit, guinea pig) | glycolipid | IG/TM | 1q22-q23 | Thy |
||||||||
semaphorin | semaphorin B, SEMB, SEMAB, SEMA4A (human) | 1q22 |
Ma | |||||||||
semaphorin D, collapsin 1, SEMA3A (human) |
|
1 | 7p12.1 | FKHR | ||||||||
SEMA3B,
SemA, SEMA5, SEMAA, LUCA1 (human) |
induce |
3p21.3 |
||||||||||
SEMA3C (human) | 7q21-q31 | TNFa |
||||||||||
SEMA3D (human) | 7q21.11 | |||||||||||
SEMA3E (human) | 7q21.11 | |||||||||||
semaphorin J, SEMA4D , CD100 (human, mouse) | CD45, CD72 | Sema/PSI/IG/TM | 1 | 9q22-q31 | CD40, LPS | B, T, NK, APCs |
||||||
SEMA5A,semF, SEMAF (human) | 5p15.2 | VEGF, ARNT2 | ||||||||||
SIMA7A, JMH, CD108 (human, zebrafish) | CD232 | Sema/PSI/IG/GPI | 15q22.3-q23 | |||||||||
plexin | PLXNA1, PLXN1, NOV (human, mouse, Xl, Dm, Ce) | neuropilin-1, SEMA3A | Sema/PSIx3/IGx4/TM(HAMP)/RasGAPx2 | 3q21-qter | CIITA | |||||||
PLXNA2 (human, mouse) | Sema/PSIx3/IGx4/TM(HAMP) | 1q32.2 | b-catenin | |||||||||
PLXNA3, SEX (human, mouse) | Sema/PSIx3/IGx4/TM | Xq28 | ||||||||||
PLXNA4 (human, mouse) | Sema/PSIx3/IGx4/TM | 7q32.3 | ||||||||||
PLXNB1, PLXN5, SEP (human, mouse) | Sema/PSIx3/IGx3/cc | 3p21.31 | ||||||||||
PLXNB2 (human, mouse) | Sema/PSIx3/IGx3/cc | 22q13.33 | estrogen | |||||||||
PLXNB3 (human, mouse) | Xq28 | |||||||||||
PLXNC1, VESPR (human, mouse) | PSIx2/TIG/IG/TM | 12q23.3 | FSH | |||||||||
PLXND1 (human) | 3q21.3 | |||||||||||
IGSF | IGSF2, V7, CD101 (human) | IGx7/TM | 1p13 | NF-ATc | ||||||||
IGSF3 (human) | 1p13 |
Group | Protein | Species | apoptosis |
|
Binding Partner | Structure | KO | gene | locus | regulators | 3D | memo |
LIR | ILT2, LIR1, CD85J, MIR7, LILRB1 (human) |
|
HLA-A, B, HLA-G1, HLA-F (MHC-I), SHP1 | IGx4/TM/ITIM | 19q13.4 | 1 | APCs, inhibit T act. | |||||
ILT4, LIR2, LILRB2, CD85D (human) | HLA-A,B,G1,F | IGx4/TM/ITIM | 19q13.4 | Fas,
IL13 |
||||||||
LIR3, ILT5, LILRB3, CD85A, LILRB3 (human) | MHC-I | IGx4/TM/ITIM | 19q13.4 | |||||||||
LIR4, ILT6, HM43, CD85E, LILRA3 (human) | FcRgamma | IGx4 | 19q13.4 | TIMP1 | APCs |
|||||||
LIR5, ILT3, LILRB4, CD85K (human) | MHC-I | IGx2/TM/ITIM | 19q13.4 | St PhoP, Fas | APCs |
|||||||
LIR8, LILRB5, CD85C (human) | FcRgamma | IGx4/TM/ITIM | 19q13.4 | |||||||||
LIR7, ILT1, CD85H, LILRA2 (human) | FcRgamma | IGx4/ITAM | 19q13.4 | IFNa | APCs |
|||||||
ILT7, CD85G (human) | FcRgamma | IGx4/ITAM | 19q13.4 | mDC |
||||||||
ILT8, CD85B (human) | FcRgamma | IGx4/ITAM | 19q13.4 | APCs |
||||||||
LIR6, LILRA1, CD85E (human) | FcRgamma | IGx4/ITAM | 19q13.4 | |||||||||
ILT11, LIR9, CD85F (human) | FcRgamma | IGx2/ITAM | 19q13.4 | preDC |
||||||||
ILT10, CD85M (human) | FcRgamma | IGx3 | 19q13.4 | |||||||||
LAIR1 (human) |
|
Ep-CAM, SHP1,SHP2, | 19q13.4 | G-CSF | APCs, B, T, NK |
|||||||
KIR (for NK) | KIR2DL1/NKAT1(human) | HLA-C4,2,5,6 (MHC-I), B4 (/w S1), SHP1, SHP2 | IGx2/TM/ITIMx2 | 19q13.4 | NK |
|||||||
KIR2DL2/NKAT6(human) | HLA-C1,3,7,8 (MHC-I) | IGx2/TM/ITIMx2 | 19q13.4 | L | NK | |||||||
KIR2DL3, NKAT2, CD158b(human) | HLA-C1,3,7,8 (MHC-I) | IGx2/TM/ITIMx2 | 19q13.4 | 1 | NK |
|||||||
KIR2DL4, CD158d(human) | HLA-G, SHP2, SHP1(-) | IGx2/TM/ITIM | 19q13.4 | NK, CD30 | ||||||||
KIR2DL5 (human) | IGx2/TM/ITIM | 19q13.4 | NK |
|||||||||
KIR3DL1, NKAT3, NKB1, CD158e (human) | IGx2/TM/ITIM | 19q13.4 | NK |
|||||||||
KIR3DL2, NKAT4, CD158z (human) | HLA-A | IGx2/TM/ITIM | 19q13.4 | NK |
||||||||
KIR3DL7 (human) | 19q13.42 | NK |
||||||||||
KIR2DS1, CD158H (human) | HLA-C2,4,5,6, Syk, ZAP70 | IGx2/ITAM | 19q13.4 | NK |
||||||||
KIR2DS2, NKAT5, CD158J (human) | HLA-B, C | 19q13.4 | NK |
|||||||||
KIR2DS3, NKAT7 (human) | 19q13.4 | NK |
||||||||||
KIR2DS4, NFAT8, CD158G (human) | HLA-C4 | 19q13.4 | NK |
|||||||||
KIR2DS5, NFAT9, CD158G (human) | 19q13.4 | NK |
||||||||||
KIR2DS6, KIRX, CD158C (human) | ||||||||||||
KIR3DS1, NKAT4, CD158k (human) | IGx2/ITAM | 19q13.4 | NK |
|||||||||
KIR3DL2 (human) | 19q13.4 | NK |
||||||||||
IRTA1 (human) | IGx4/IM/ITIM | 1q21 | ||||||||||
IRTA2, BXMAS1 (human) | IGx9/TM/ITIM | 1q21 | B |
|||||||||
FCRH3 (human) | IGx4/IM/ITIM | 1q21.2-q22 | ||||||||||
NCR | LY95, NKp44, NCR2 (human) | HA, CD3zeta, DAP12, | IG/TM | 6p21.1 | IL2 | |||||||
LY94, NKp46 (human) | HA, HN | IGx2/TM | 19q13.42 | Mt, camptothecin, | NK |
|||||||
LY117, NKp30, 1C7 (human) | viral proteins | IG | 6p21.3 | NK, (T, B) |
||||||||
Butyrophilin |
Butyrophilin A1, BTN1A1 (human, mouse) | IG/TM/SPRY(ZF) | 1 |
6p22-p21.3 | fat droplets in the milk | |||||||
BTN2A1, BTF1 (human) | IGx3 |
6p22.1 | T, NK, B |
|||||||||
BTF1, BT2.1, BTN2A2 (human) |
6p22.1 | |
||||||||||
BTN2A3 (human) |
6p22.1 | |||||||||||
BTF5, BT3.1, BTN3A1 (human) |
6p22.1 | T, NK |
||||||||||
BTF4, BT3.2, BTN3A2 (human) |
6p22.1 | T, NK, (B) |
||||||||||
Butyrophilin 3, BTN3A3 (human) |
6p21.3 | dsRNA | NK, T, (B) |
|||||||||
Butyrophilin 2, BTNL2, BTL-II, HSBLMHC1 (human) | 6p21.3 | A2aR | sarcoidosis
|
|||||||||
BTNL3 , BTNLR (human) | IG/TM/PRY/SPRY | 5q35.3 | ||||||||||
BTNL8 (human) |
5q35.3 |
PBL |
||||||||||
BTNL9 (human) |
5q35.3 | PBL | ||||||||||
a1B | a1B-glycoprotein, A1B, ABG, GAB, A1BG (human, rat) | CRISP3 | IGx5 | 19cen-q13.2 | Liver |
|||||||
beta-2-microglobulin | B2M (human, mouse, rat) | CD1s |
IG | L | 15q21-q22 | NF-kB, GR, IRF1, TNFa, IL1, LPS, IFNg, IL1b/IFNg, MDV, HCV, IKKs | ||||||
MHC-I | HLA-A(human),B-L | mediate | mediate | TCR, antigen, MIR | MHCI/IG/TM | L | 6p21.3 | AP1, NF-kB, Ets1, TNFa, TRAIL, RANKL, Fas, IL1, IFNs, CREB, PLZF, CBP, p300, PCAF, BRG1, CIITA, RA, IL1b/IFNg, LPS, hsp65, Hp, Hf, Sd, dsDNA, dsRNA, MDV, EV71, hypoxia, CSV-B3, HNF4a, IKKs, ALK1, TGFR1, calcineurin, T3, androgen, HHT | L | targets |
||
FcRn, FCGRT (human) | B2M, IgG | MHCI/IG/TM | 19q13.3 | IFNa, calcineurin | 1 | APCs, liver, passive immunity by milk | ||||||
MHC-II | HLA-DMa(human), b, DNa,DOa, DPa1, DPa2, DPb1, DPb2, DQa1, DQa2, DQb1-3, DRa, DRb1-9 | mediate/inhibit | mediate | TCR, antigen, CD1d | MHCII/IG/TM | L | 6p21.3 | RFX5, RFX1, RFXAP, RFXANK, CIITA,NF-Y, CREB, Oct1, C/EBPa, AP1, AIRE, c-Myc, NF-IL6, STAT3, Stat4, ARNT2, TAF1, HDAC1, IFNg, IL1b/IFNg, GM-CSF, TNFa, Fas, CD40L, CD3/CD28, IL12, IL15, jagged-1, IL10, GM-CSF, insulin, IGF-II, LPS, hsp65, MDP, Hp, Hf, Sd, CpG, dsDNA, dsRNA, HCV, EBV, EV71, VLP, PTEN, Lyn, A2aR, TIMP1, triptolide, estrogen, androgen, RA, camptothecin | L | APCs, B, targets |
||
MIC | MICA (human), mouse (RAEI, H60) | NKG2D | MHCI/IG/TM | 6p21.3 | stress, IFNg, IL15 | epithelial |
||||||
MICB (human) | NKG2D | MHCI/IG/TM | 6p21.3 | stress, IFNg, IL15 | epithelial | |||||||
CD74, HLA gamma, invariant chain (human),mouse, rat, horse, bovine, | CD74 | 1 | 5q32 | androgen,
HCV,
Lyn,
TIMP1 |
B, DC |
|||||||
CD92, CDw92, CTL1 (human) | CD74/DUF580 | 9q31.2 |
Group | Protein | apoptosis | Species |
|
KO | 3D | binding partner | structure | TFs | upstream regulators | memo |
CAM | ALCAM, MEMD, CD166 | human, mouse, rat, dog, chicken | 3q13.1-q13.2 | CD6 | IGx5/TM | RANTES, LPS, IL3, M-CSF, GM-CSF, Blimp1 | |||||
CD22, LEU14, BL-CAM, SIGLEC2 |
|
human, mouse | 19q13.1 | L | sialylated staffs, CD45, AP50, SHIP1/Grb2/Shc | IGx7/TM | IL1b, Fas, BCR, Lyn, LPS, GR, IKKg | B vs B | |||
MAG, SIGLEC4A | human,
mouse |
19q13.1 | sialosides | IGx4/TM | DEX,
cAMP |
brain |
|||||
LU, BCAM | human | 19q13.2 | IGx5/TM | ||||||||
nephrin, Nphs1 | human | 19q13.1 | 1 | IGx8/FN3/TM | |||||||
CD33, SIGLEC3 | induce |
human | 19q13.3-q13.4 | 1 | sialosides | SDF1,
Lm |
APCs |
||||
SIGLEC5, CD33L2, OBBP2 | human | 19q13.3 | sialosides | IGx3/TM | bm |
||||||
Nr-CAM, Bravo, NRCAM |
human, mouse, rat, chicken | 7q31.1-q31.2 | contactin/F11, neurofascin, RPTPb, axonin-1 | IGx6/FN3x3/TM | LEF-1 | IL1a, b-catenin, Wnt | brain |
||||
DDM36, NOPE |
human | 15q22.2 | |||||||||
neogenin, NEO1 | human | 15q22.3-q23 | IGx6/FN3x6/TM | Pax6 | |||||||
PUNC | human | 15q22.3-q23 | 1 | IGx4/FN3x2/TM | |||||||
MYBPC3 | human | 11p11.2 | IGx6/FN3x2/IG/FN3/IG | heart |
|||||||
MYBPC2, fast | human | 19q13.33 | IGx5/FN3x2/IG/FN3/IG | heart, tongue |
|||||||
MYBPC1, slow | human | 12q23.3 | IGx5/FN3x2/IG/FN3/IG | skeletal muscle, tongue |
|||||||
contactin 1, CNTN1 | human, mouse, rat, bovine, chicken,zebrafish | 12q11-q12 | 1 | tenascin, Fyn, RPTPbeta, Caspr, NF155, Na+ channel | IGx6/FN3x4 | St PhoP | brain |
||||
contactin 2, CNTN2, TAX1, TAG1, axonin 1 | human, rat, chicken, zebrafish | 1q32.1 | 1 | IGx6/FN3x4 | brain |
||||||
neurofascin, NFASC | human, rat, | 1q32.1 | contactin, Na+
channel, Nr-CAM,
syntenin-1,
ankyrin |
IGx6/FN3x3/TM | |||||||
IGSF9, Nrt1 | human | 1q22-q23 | IGx4/FN3x2/TM | ||||||||
L1CAM, MIC5, MASA, SPG1, HSAS1, N-CAML1 CAML1, CD171 |
human,
mouse,
rat, |
Xq28 | 1 | IGx6/FN3x4/TM | Pax6 | brain |
|||||
contactin 5, NB2, CNTN5 | human, rat | 11q21-q22.2 | |||||||||
contactin 3, CNTN3, NIG1, PANG | human, mouse, rat | 3p26 | |||||||||
contactin 4, BIG2, CNTN4, Axcam | human, mouse, rat, | 3p26-p25 | IGx6/FN3x4 | ||||||||
contactin 6, NB3, CNTN6 | human, mouse, rat | 3p26-p25 | IGx6/FN3 | ||||||||
CALL, L1CAM2, CHL1 |
|
human | 3p26.1 | IGx6/FN3x4/TM | brain |
||||||
ROBO1, roundabout 1 | human | 3p12 | IGx5/FN3x2 | TNFa | |||||||
ROBO4 | human | 11q24.2 | IGx2/FN3x2 | ||||||||
BOC | human | 3q13.2 | IGx4/FN3x3/TM | ||||||||
JAM3 | human, mouse | 11q25 | |||||||||
JAM2, VEJAM | human, mouse | 21q21.2 | |||||||||
DSCAM, CHD2-42, CHD2-52 |
human | 21q22.2 | IGx9/FN3x2/IG/FN2/TM | ||||||||
NCAM2 | human | 21q21.1 | IGx5/FN3x2/TM | EV71 | |||||||
NCAM1, CD56 | human, mouse, rat, bovine, chicken, Xl, zebrafish | 11q23.1 | L | 1 | prion | IGx5/FN3x2/TM | NF-kB, Phox2, HOXC6, Hoxc8, Alx4, LEF-1, PLZF, OTX2, Cux-2?, Barx1, p73 | TGFb, BMP2, AMPA-R, D2R | NK |
||
CDON, CDO, ORCAM | human | 11q23-q24 | IGx5/FN3x3/TM | ||||||||
DSCAML1, KIAA1132 | human | 11q23 | IGx9/FN3x4/IG/FNx2/TM | ||||||||
SDK2, sidekick 2 | human | 17q25.2 | IGx3/FN3x5/TM | ||||||||
DCC, CRC18, CRCR1 |
|
human | 18q21.3 | 1 | IGx4/FNx6/TM | ||||||
VCAM1, CD106 |
|
human, mouse, rat, pig | 1p32-p31 | 1 | L | integrins, CD29 | IGx6/TM | NF-kB, Egr1, AP-1, IRF1, IRF2, GATAs, Sp1,PPARa, | IL1,
TNFa,
LTa,dsRNA,
IFNs,AngII,
IL4,
IL5,
IL18,
PKR,
LDL,
thrombin,
C5a,
Resistin,
NO,
RA,
estrogens,
glucocorticoids,
UTP,
LPS,
BLP,
Ct,
Hp,
Mt,
Pc,
ApoE,
tax,
osmolarity,
P2Y2,
p38,
BMP2,
IL10,
ALA |
||
ICAM1, CD54 | inhibit/(-)/mediate | human, mouse, rat, pig, sheep, bovine | 19p13.3-p13.2 | L | L | LFA-1, rhinoviruses, CD11, CD43, MIR | IGx5/TM | NF-kB,
p53,
c-Myc,
EGR1,
DLX-7,
HOXD10,
PDX1 |
IL1, IL5, IL6, IL18, TNFa, LTa, TRAIL, Fas, IFNa, PMA, CD3/28, BCR, C4BP, histamine, C5a, ML-1, LPS, BLP, LTA, MDP, OX-CA, LeIF, hsp65, Bm, Cp, Ct, Ld, Lm, Ma, Mt, Pc, St, Tg, CMV(IE2, pp70), MV, HHV8, oxidative stress, irrrad, hypoxia, IFNg, RA, glucocorticoid, p38, PKCd, Src, Nef, IL1b/TNFa, heat shock, PGE2., IL10 | ||
ICAM3, CD50 |
|
human, bovine | 19p13.3-p13.2 | LFA-1, CD11, CD209 | IGx4/TM | IFNa | B, T, APCs |
||||
ICAM4 | human | 19p13.2-cen | LFA-1 | IGx2/TM | |||||||
ICAM5, TLCN, TLN | human, mouse | 19p13.2 | IGx7/TM | ||||||||
PECAM1, CD31 |
|
human, mouse, bovine, pig, | 17q23 | L | CD38, Fyn, Lyn, Src, Yes, Hck, SHP1, SHP2, alphavbeta3 integrin, | IGx5/TM/ITIM | NF-kB, Egr1 | TNFa, Fas, IFNa, IFNg, PMA, camptothecin | APCs |
||
ICAM2, CD102 |
|
human, mouse | 17q23-q25 | 1 | 1 | LFA1, CD11b/CD18, CD209 | IGx2/TM | GATA2, | TNFa, IL1, VEGF, Cp, Yp, ALK1 | ||
TCAM1 | mouse, rat | testis |
|||||||||
CMRF35 | human | 17q22-q24 | IG/TM | Fas, camptothecin | monocyte |
||||||
CMRF35H9, IRC1 | human | 17q22-q24 | IG/TM | NK, APCs |
|||||||
TREM4, LOC146894 | human | 17q21.31 | IG/TM | ||||||||
NKIR | human | 17q25.2 | IG/TM | ||||||||
TACTILE | human | 3q13.2 | IGx3/TM | T, NK |
|||||||
LAMP, LSAMP | human | 3q13.2-q21 | IGx3/TM | ||||||||
IGSF10, CMF608, FLJ25972 | human | 3q25.1 | IGx7 | ||||||||
MAdCAM1 | human, mouse, rat | 19p13.3 | L | CD29 | IG | NKX2.3 | Hp,
b-catenin |
||||
CEA, CEACAM5, CD66e |
|
human | 19q13.2 | IG x7 | c-Myc, PPARg | LPS,cisplatin | |||||
CD66a, BGP, CEACAM1 |
|
human | 19q13.2 | 1 | Src, SHP1, SHP2, galectin-3 | IGx3/TM/ITIM | Hoxd10 | RA, VEGF | |||
CGM1, CD66d, CEACAM3 |
|
human | 19q13.2 | IG/TM | |||||||
CEAL, NCA, CD66c, CEACAM6 |
|
human | 19q13.2 | IG x7 | estrogen, As2O3 | lung, bm |
|||||
CEACAM7, CGM2 | human | 19q13.2 | IGx2 | RA | |||||||
CD66b, CD67, CGM6, NLA95, CEACAM8 | human | 19q13.2 | galectin-3 | IGx3 | hemin, PACAP | ||||||
PSG3 | human | 19q13.2 | IGx4 | placenta |
|||||||
PSG8 | human | 19q13.2 | placenta |
||||||||
PSG10 | human | 19q13.2 | placenta |
||||||||
PSG1 | human | 19q13.2 | placenta | ||||||||
PSG6 | human | 19q13.2 | placenta | ||||||||
PSG7 | human | 19q13.2 | placenta | ||||||||
PSG11 | human | 19q13.2 | placenta | ||||||||
PSG2 | human | 19q13.2 | placenta | ||||||||
PSG5 | human | 19q13.2 | Sp1 |
placenta | |||||||
PSG4 | human | 19q13.2 | placenta | ||||||||
PSG9 | human | 19q13.2 | placenta | ||||||||
TSLL2 | human | 19q13.32 | IGx3/TM/4.1m | ||||||||
SIGLEC7 | human | 19q13.3 | 1 |
sialic acid, disialogangliosides, sialosides | IGx3/TM | Fas, camptothecin | NK, APCs |
||||
SIGLEC8, SAF2 | human | 19q13.33-q13.41 | sialosides | IGx3/TM | |||||||
SIGLEC9 | human | 19q13.41 | sialosides | ||||||||
SIGLEC10 | human | 19q13.3 | IGx4/TM | B, NK |
|||||||
SIGLEC11 | human | 19q13.33 | IGx4/TM | adrenal gland |
|||||||
SIGLECL1 | human | 19q13.4 | IGx4/TM | ||||||||
OSCAR | human | 19q13.42 | IGx2/TM | PU.1 | |||||||
PVR, PVS, CD155 |
|
human | 19q13.2-q13.3 | mt | PV, vitronectin, Tctex-1 | NRF1, GLI1, GLI3 | Shh,
CMV |
||||
basigin, BSG, TCSF, EMMPRIN, CD147 |
human,
mouse,
rat,
chicken,
zebrafish |
19p13.3 | L | basigin,
MCT1,
MCT4 |
IGx2/TM | Stat4b | TSH |
bm |
|||
SDFR1, gp65, gp55 | human | 15q22 | IGx2/TM | brain |
|||||||
embigin, gp70IC | human, mouse, rat | 5q11.2 | IGx2/TM | bm |
|||||||
MGC71745 |
human |
5q11.2 |
IGx2/TM | NK, B, T, APCs |
|||||||
sialoadhesin, SN, CD169, SIGLEC1 |
human | 20p13 | L |
sialic acid, sialosides | IGx17/TM | IL-4,
IFNb, IFNg, LPS |
bm |
||||
NEPH1, KIRREL |
human |
1q21-q25 |
IGx4/TM | ||||||||
NEPH2, Kirre, SST4 | human | 11q24 | IGx5/TM | ||||||||
MCAM, MUC18, CD146 | human | 11q23.3 | IGx5/TM | AP2 | TNFa, IL1, hCG, PMA, cAMP | ||||||
SYNCAM, TSLC1, BL2, ST17, IGSF4 | human | 11q23.2 | IGx3/TM/4.1m | ||||||||
HVEC, PVRR1, PRR, nectin 1, PVRL1 | human | 11q23-q24 | 1 | afadin, HSV | IGx3/TM | Ma, Fas, camptothecin | |||||
nectin 2, Pvrl2, CD112, HVEB, PVR, PVS | human, mouse | 19q13.2-q13.4 | 1 | IGx3/TM | |||||||
PVRL3, PPR3, PRR3, PVRR3,
nectin-3, |
human |
3q13 |
afadin |
placenta |
|||||||
CD47, IAP |
|
human, mouse, rat, bovine, viruses | 3q13.1-q13.2 | L | SIRPs, alpha v beta 3 vitronectin, Rh, SHPS1 | IG/TMx5 | Yp,
MVA,
EV71,
TNF,
IL1,
GM-CSF,
NIP3,
SDF1 |
||||
CD200R, OX2R, MOX2R | human | 3q13.2 | CD200 | IGx2/TM | |||||||
CD200, OX2, MOX2 | human | 3q12-q13 | 1 | CD200R | IGx2/TM | ||||||
CAM(IG) | SNS, CG33141 | Dm, Ag | IGx9/FN3/TM | ||||||||
CG8964 | Dm |
Group | Protein | apoptosis | Species |
|
KO | 3D | binding partner | structure | TFs | upstream regulators | memo |
CD2 | CD48 |
|
human, mouse, rat | 1q21.3-q22 | heparan sulfate, CD2, 2B4, Lck, CD2BP1, Lyn, Fyn | IG/TM | PLZF | Yp,
EBV,
G-CSF,
IL13,
TRAF2/TRAF5 |
B, T, NK, APCs |
||
BY55, CD160 | human | 1q21.1 | MHC-I | IG/GDI | TCR |
NK | |||||
IGSF4B, NECL1, TSLL1 | human | 1q21.2-q22 | IGx2/TM/4.1m | brain |
|||||||
LFA3, CD58 |
|
human | 1p13 | 1 | CD2 | IG/TM | p53 | IL2, LPS, RA, DEX | |||
AD026 | human | 1p12 | IG | ||||||||
CD2 |
|
human, hourse, | 1p13.1 | 1 |
L | CD48, CD2BP1, CIN85, CMS | IGx2/TM | Ma, PTH, Notch | T, NK |
||
CD84 | human | 1q24 | CD2
family members, SHP2, SAP |
IGx2/TM | D3 | T |
|||||
SLAM, CD150 | human, mouse | 1q22-q23 | SAP | IGx2/TM | GR, STAT3 | IL1, IL10, PMA,BCR, LPS, Hp | Thy |
||||
Ly9, CD229 | human, mouse | 1q21.3-q22 | SAP, CD48, AP-2 | IGx2/TM | AIRE | T, DC |
|||||
2B4, CD244, Nmrk | human, mouse,rat | 1q23.1 | 1 |
CD48 | IGx2/TM | Rac2,
TCR |
NK | ||||
BLAME | human | 1q22 | IGx2/TM | ||||||||
SLAMF6, NTBA, KALI | human | 1q22 | SHP1, SHP2, SAP | IGx2/TM/(TxYxxV/I)x2/ITIM | |||||||
LNIR, PRR4, PVRL4 | human | 1q22-q23.2 | IGx3/TM | ||||||||
SLAMF7, 19A24, CRACC, CD1 | human | 1q23-q24 | IG/TM | DC, NK |
|||||||
SLAMF9, CD84-H1 | human | 1q22 | IG/TM | ||||||||
F11R, JAM1, PAM-1 | human, mouse, rat, bovine | 1q21.2-q21.3 | 1 | LFA1 | IGx2/TM | IL5 | epithelial |
||||
FGFRL1 | human,
mouse |
4p16 | IGx3/TM | ||||||||
IGSF4D, NECL3 | human,
mouse |
3p12.2 | IGx3/TM/4.1m | brain |
|||||||
CD83 | CD83 | human, mouse, rat | 6p23 | 1 | sialic
acid |
IG/TM | NF-kB | TNFa, CD40L, IFNg, CD38, IL4, PA, LPS, KF1B, Hp, Ld, Lm, Mt, Sm, Tg, Ye, LMP1, PMA, D3, Blimp1, TIMP1 | B, APCs |
||
TIM | HAVCR, TIM1 | human, mouse | 5q33.2 | HAV | IG/Muc/TM | ||||||
TIM2, Timd2 | mouse | SEMA4A | IG/Muc/TM | blastcysts |
|||||||
HAVCR2, TIM3 | human, mouse | 5q33.3 | 1 | IG/Muc/TM | NK, Th1 | ||||||
TIM4, LOC91937 | human, mouse | 5q33.3 | IG/Muc/TM | ||||||||
other | pIgR | human, mouse, rat, rabbit, bovine | 1q31-q41 | 1 | IgA, CbpA, CaM, | IGx5/TM | IRF1, NF-kB, STAT6 | IFNg, IL4, TNFa, androgen | trtachea, IgA transport | ||
FKSG87, Fcalpha/muR | human | 1q31.3 | IgA, IgM | IG/? | IL1 | ||||||
Toso |
|
human, mouse, rat | 1q31.3 | FADD |
IG/TM | IL2, TCR, Hp | B, T, NK |
||||
kilon, MGC46680 | human | 1p31.1 | IGx3 | ||||||||
myopalladin, MYPN |
human | 10q22.1 | IGx5 | ||||||||
CNAIP, NFAM1 | human, mouse | 22q13.2 | IG/TM/ITAM | kidney |
|||||||
MDGA1 | human | 6p21 | IGx6/FN3/MAM/GPI | ||||||||
Thy-1, CD90 |
|
human | 11q23.3 | Mac1 |
IG | Yp | brain |
||||
neurotrimin, HNT | human | 11q25 | IGx3/GPI | ||||||||
OBCAM, OPCML | human | 11q25 | IGx3 | (brain) |
|||||||
DKFZp566D234 | human | 4q32.3 | KAZAL/EF/IGx2 | ||||||||
palladin, CGI151 | human | 4q32.3 | ezrin | (FPPPP)/IGx5 | |||||||
myotilin, TTID | human | 5q31 | ?/IGx2 | skeltal muscle, tongue |
|||||||
FLJ20674 | human | 12q24.23 | IGx3/TM | ||||||||
SIRPa1, SHPS1, MYD1, MFR, PTPNS1 |
|
human | 20p13 | SHP1 | UGx2/TM/ITIM | ||||||
IGSF1, IGDC1 | human | Xq25 | IGx5/TMx2/IGx6 | pituitary |
|||||||
WFIKKNRP | human | 17q21.33 | WAP/KAZAL/IG/KUx2/C345C | ||||||||
perlecan, HSPG2, PLC, SJA, SJS, SJS1 |
human, mouse | 1p36.1-p35 | SEA/LDLax4/IG/LamB/EGFx3/LamB/EGFx4/LamB/EGFx3/IGx21/LamG/EGFx2/LamG/EGFx2/LamG | TGFb, NO | adipocyte, s.muscle, cardiac |
||||||
hemicentin, fibulin 6, FIBL-6 | human | 1q25.3 | WVA/IGx3/TSP1x6/G2F/EGFx8 | ||||||||
hemicentin-2 | human | 9q34.2 | |||||||||
titin | human | 2q24.3 | huge! | skeletal muscle |
|||||||
LRR/IG | LRIG2, KIAA0806 | human | 1p13.1 | LRRs/IGx3/TM | |||||||
GAC1, LRRN2 | human, mouse, rat, | 1q32.1 | LRRs/IG/TM | brain |
|||||||
LRRN3, NLRR3 | human | 7q31.1 | LRRs/IG/TM | IL12, TGFb | T, brain |
||||||
FLJ31810 | human, mouse, rat | 9p21.1-p13.3 |
LRRs/IG/TM | brain |
|||||||
LERN1, UNQ201,, FLJ14594 | human, mouse, rat, | 15q24.1 |
LRRs/IG | (brain) |
|||||||
LRRN1 | human, mouse, frog | 3p26.2 | LRR/IG/FN3/TM | T |
|||||||
LRRN3 | human, mouse, rat | 7q21.12 | LRR/IG/FN3/TM | T, brain | |||||||
LIG1, LRIG1 | human | 3p14 | LRRs/IGx3/TM | ||||||||
FLJ90440 | human | 12q13.2 | LRRs/IGx4/TM | ||||||||
PAL | human | 10q23 | LRRs/IG/FN3/TM | ||||||||
adlican | human | Xp22.33 | LRRs/IGx2/?/IGx10 | adrenal |
Group | Protein | apoptosis | Species |
|
KO | 3D | binding partner | structure | TFs | upstream regulators | memo |
SRCR | CD6 |
|
human, mouse, rat | 11q13 | CD166 | SR x3/TM | PMA, Yp, D3 | T |
|||
CD5, Leu1, Ly1 |
|
human, mouse, rat, sheep, chicken, | 11q13 | 1 | CD72 | SR x3/TM/ITIM | NFATs, E47, Ets1 | TNFa, TCR, PMA, IgM, IFNa, Yp, PKCs, androgen | T |
||
DMBT1, gp340 | human | 10q25.3-q26.1 | SFTPD | SRx13/CUB/SR/CUB/ZP | trachea |
||||||
see also CD160, M160 | SRs | ||||||||||
cadherin | BR-cadherin, N-cadherin 2, CDH12 | human, mouse | 5p14-p13 | B |
|||||||
K-cadherin, CDH6 | human, mouse, rat, chicken, Xl | 5p15.1-p14 | |||||||||
cadherin 18, CDH18 (formerly CDH14) | human, rat | 5p15.2-p15.1 | brain |
||||||||
LI-cadherin, CDH17 | human, mouse, rat | 8q22.1 | Cad.R x6/TM | Cdx2 |
Sd, Sp | pancreas |
|||||
E-cadherin, cadherin-1, CDH1 | inhibit/promote | human, mouse, chicken, zebrafish | 16q22.1 | L | L | cytoskeletal proteins | Cad.R. x5/Cad/TM/Cad-C | Snail, WT1, E12/E47, SIP1, Rb, c-Myc, AP-2, | TGFb, DNA methylase, PS1, ET-1, LMP1, PMA | ||
OB-cadherin, CDH11 | human, mouse, chicken | 16q22.1 | PDGF | s.muscle, cardiac, adipocyte |
|||||||
P-cadherin, cadherin-3, CDH3 | human, bovine, pig | 16q22.1 | L | cytoskeletal proteins | Cad.R. x5/ Cad/ TM/ Cad-C | ErbB2,
ARNT2 |
|||||
VE-cadherin, CDH5, CD144 |
|
human, mouse, pig | 16q22.1 | 1 | b-catenin, p120CAS | Cad.R. x5/ Cad/ TM/ Cad-C | Sp1, Sp3, Erg, Ets1, Egr1, | RANKL | lung, placenta |
||
cadherin 8, CDH8 | human, mouse, rat | 16q21-q22.1 | |||||||||
KSP-cadherin, CDH16 | human | 16q22.1 | kidney |
||||||||
M-cadherin, cadherin-15, CDH15 | human, mouse | 16q24.3 | MVA,
Pg |
||||||||
T-cadherin, cadherin 13, CDH13 | human, mouse, rat, chicken | 16q24.2-q24.3 | Cad.R x5 | NF-kB | TNFa, IKKs, irrad | ||||||
T1-cadherin, CDH9 | human | 5p14 | |||||||||
T2-cadherin, CDH10 | human, chicken | 5p14-p13 | brain |
||||||||
BH-cadherin, PCDH7, BHPCDH | human, chicken | 4p15 | PP1a | Cad.R x7/TM | NF-kB | TNFa, IL1, IKKs | |||||
R-cadherin, cadherin-4, CDH4 | human, mouse, rat | 20q13.3 | brain |
||||||||
PB-cadherin, CDH22 | human, mouse, rat | 20q13.1 | PTH | brain |
|||||||
VR20, CDH26 | human | 20q13.2-q13.33 | epithelium |
||||||||
N-cadherin, cadherin-2, CDH2 |
|
human, mouse, bovine, chicken, zebrafish | 18q11.2 | L | L | cytoskeletal proteins | Cad.R. x5/ Cad/ TM /Cad-C | MyoD | Rac2 | s. muscle, cardiac |
|
cadherin 7, CDH7 | human, chicken | 18q22-q23 | |
||||||||
cadherin 19, CDH19 (formerly CDH7) | human | 18q22-q23 | DRG |
||||||||
cadherin 20, CDH20 | human, mouse | 18q22-q23 | |||||||||
desmocollin 1, DSC1 | human, mouse | 18q12.1 | 1 |
Cadx5/TM | NF-IL6 | skin, desmosome | |||||
desmocollin 2, DSC2 | human, mouse | 18q12.1 | tongue, epithelium |
||||||||
desmocollin 3, DSC3 | human, mouse, bovine | 18q12.1 | TNFa | epithelium, tongue, skin |
|||||||
desmoglein 1, DSG1 | human, bovine | 18q12.1 | Cadx5/CAD-C | skin, tongue |
|||||||
desmoglein 2, DSG2 | human, mouse | 18q12.1 | epithelium |
||||||||
desmoglein 3, PVA, DSG3 | human, mouse | 18q12.1-q12.2 | 1 | epithelium, tongue, tonsil |
|||||||
desmoglein 4, DSG4 | human | 18q12.1 | |||||||||
PCDH10 | human | 4q28.3 | brain |
||||||||
PCDH15 | human | 10q21.1 | av | ||||||||
PCDH18 | human | 4 | Disabled-1 | adipocyte |
|||||||
FAT | human | 4q34-q35 | Cadx34/EGF/LamininG/EGFx4/TM | epithelium |
|||||||
FAT2, MEGF1 | human, rat | 5q32-q33 | cerebellum |
||||||||
otocadherin, CDH23 | human, mouse,rat | 10q21-q22 | mt |
group | name | apoptosis | species | locus | KO | 3D | binding partner | structure | TFs | upstream regulators | memo |
protocadherin | alpha 1, PCDHA1 | human | 5q31 | brain |
|||||||
PCDHA2 | human | 5q31 | brain |
||||||||
PCDHA3 | human | 5q31 | brain |
||||||||
PCDHA4 | human | 5q31 | brain |
||||||||
PCDHA5 | human | 5q31 | brain |
||||||||
PCDHA6 | human | 5q31 | brain | ||||||||
PCDHA7 | human | 5q31 | brain | ||||||||
PCDHA8 | human | 5q31 | brain | ||||||||
PCDHA9 | human | 5q31 | IL1 |
brain | |||||||
PCDHA10 | human | 5q31 | brain | ||||||||
PCDHA11 | human | 5q31 | brain | ||||||||
PCDHA12 | human | 5q31 | brain | ||||||||
PCDHA13 | human | 5q31 | TNFa |
brain | |||||||
PCDHB1 | human | 5q31 | |||||||||
PCDHB2 | human | 5q31 | |||||||||
PCDHB3 | human, mouse | 5q31 | |||||||||
PCDHB4 | human, mouse | 5q31 | |||||||||
PCDHB5 | human, mouse | 5q31 | |||||||||
PCDHB6 | human, mouse | 5q31 | |||||||||
PCDHB7 | human, mouse | 5q31 | |||||||||
PCDHB8 | human | 5q31 | |||||||||
PCDHB9 | human | 5q31 | |||||||||
PCDHB10 | human | 5q31 | |||||||||
PCDHB11 | human | 5q31 | |||||||||
PCDHB12 | human | 5q31 | |||||||||
PCDHB13 | human, mouse | 5q31 | |||||||||
PCDHB14 | human, mouse | 5q31 | |||||||||
PCDHB15 | human, mouse | 5q31 | |||||||||
PCDHB16 | human, mouse | 5q31 | |||||||||
Pcdhb22 | mouse | ||||||||||
protocadherin gamma A1, PCDHGA1 | human, mouse | 5q31 | brain |
||||||||
PCDHGA3 | human, mouse | 5q31 | brain |
||||||||
PCDHGA4 | human | 5q31 | brain |
||||||||
PCDHGA5 | human | 5q31 | brain | ||||||||
PCDHGA6 | human | 5q31 | brain | ||||||||
PCDHGA7 | human | 5q31 | brain | ||||||||
PCDHGA8 | human, mouse | 5q31 | brain | ||||||||
PCDHGA9 | human, mouse | 5q31 | brain | ||||||||
PCDHGA10 | human | 5q31 | brain | ||||||||
PCDHGA11 | human | 5q31 | brain | ||||||||
PCDHGA12 | human | 5q31 | brain | ||||||||
protocadherin gamma B1, PCDHGB1 | human, mouse | 5q31 | brain |
||||||||
PCDHGB2 | human, mouse | 5q31 | brain |
||||||||
PCDHGB3 | human | 5q31 | brain | ||||||||
PCDHGB4 | human | 5q31 | Cadx5/TM | brain | |||||||
PCDHGB5 | human | 5q31 | brain | ||||||||
PCDHGB6 | human | 5q31 | brain | ||||||||
PCDHGB7 | human, mouse | 5q31 | brain | ||||||||
Pcdhgb8 | mouse | 5q31 | |||||||||
protocadherin gamma C3, PCDHGC3 | human | 5q31 | brain | ||||||||
PCDHGC4 | human, mouse | 5q31 | brain |
||||||||
PCDHGC5 | human | 5q31 | brain |
||||||||
PCDH12 | human | 5q31 | brain |
||||||||
PCDH1 | human | 5q32-q33 | |||||||||
PCDH19 | human | Xq13.3 | brain |
||||||||
PCDH11X | human | Xq21.3 | |||||||||
PCDH11Y, protocadherin-PC |
|
human | Yp11.2 | ||||||||
protocadherin 15, PCHD15 | human, mouse | 10q21-q22 | US | Cadx11/TM | |||||||
protocadherin 16, PCDH16 | human | 11p15.4 | |||||||||
PCDH8, PAPC | human | 13q14.3-q21.1 | Mesp2 | brain, epithelium boundary | |||||||
PCDH9 | human | 13q14.3-q21.1 | brain |
||||||||
PCDH17 | human | 13q14.3 | IL1 |
brain |
|||||||
PCDH20 | human | 13q21 | brain |
||||||||
CDH24, FLJ25193 | human | 14q11.2 | Cadx4 | ||||||||
also see flamingo subfamily of 7TM |
group | name | apoptosis | species | locus | KO | 3D | binding partner | structure | TFs | upstream regulators | memo |
integrin | alpha 1, CD49a, ITGA1 | human, mouse, rat, | 5q11.1 | 1 | FG-GAP/VWA/FG-GAPx4 | Sd, Ct | |||||
alpha 2, CD49b, ITGA2 |
|
human, mouse, bovine | 5q23-31 | FG-GAP/VWA/FG-GAPx4/TM/Int_A | Sp1, Osf | PMA, PDGF, SCF, IFNa, Lm, PKCzeta, Erb-B2, v-Ras, hypoxia, HHV8 | |||||
alpha 2b integrin, CD41, |
human, mouse | 17q21.32 | FG-GAPx5/TM/Int_A | C/EBP | bm |
||||||
alpha 3, CD49c, ITGA3 |
|
human, mouse | 17q23.3 | TM4SFs | FG-GAPx5/TM | Ma, irrrad, RANKL | epithelium |
||||
alpha 4 , CD49d, ITGA4 |
|
human, mouse | 2q31-q32 | 1 | TM4SFs | IL-2RIF,
IL6,
LPS,
Pg, TIMP1 |
B, T, NK, APCs |
||||
alpha 5 , CD49e, ITGA5 |
|
human, mouse, Xl | 12q11-q13 | 1 | TM4SFs, ADAM17 | Sp1, Sp3, Smad4, C/EBP, Ets | LPS,
OX-CA,
Ct, TNFa,
RANKL,
IL10,
TGFb1,
IGFBP2,
IGF1 |
||||
alpha 6 , CD49f, ITGA6 | human, mouse, chicken | 2q31.1 | TM4SFs | c-Myc | CD3,
insulin,
IGF1,
insulin,
FSH,
TGFb1,
Tprim,
RA, hypoxia,
MA3Ks,
IGFBP2,
LPS,
Sm |
epithelium |
|||||
alpha 7, ITGA7 | human, mouse | 12q13 | Stat4 | b-glucan, Ma, BMP2, BMPs, HIV Vpr | heart, adipocyte |
||||||
alpha 8, Itga8 | human | 10p12.32 | 1 | cisplatin, phenytoin | |||||||
alpha 9, ITGA9 | human, mouse | 3p21.3 | estrogen | ||||||||
alpha 11, ITGA10 | human | 1q21 | |||||||||
alpha 11, ITGA11 | human | 15q22.3-q23 | |||||||||
alpha E integrin, CD103 | human, mouse, rat E1, | 17p13 | E-cadherin, beta 7 integrin | TGFb, Ct, Pg, ALK1, ALK5, PMA, cisplatin, estrogen | |||||||
alpha L, CD11a, LFA-1a, ITGAL | human, mouse | 16p11.2 | 1 | MDP,
Cp,
Ma,
EV71,
RANKL,
IFNa |
T, NK |
||||||
alpha M, CD11b, MAC1A, MO1A, ITGAM, CR3A |
|
human, mouse, rat | 16p11.2 | 1 | Sp3 | SCF, TNFa, LTa, IL2, IL4, hemin, PACAP, Am80, MDP, Ma | bm, NK, induce NF-kB |
||||
alpha V integrin, CD51, ITGAV |
|
human, mouse, chicken | 2q31-q32 | ADAM15, alphaV, ntin | GATA1 | TNFa, PMA | |||||
alpha X integrin, CD11c, ITGAX | human, mouse, rat | 16p11.2 | Sp1, Sp3, AP1, Ets,Oct2, c-Myc, GABP, Pur alpha, PU.1 | GM-CSF,TNFa,LTa, IL2, IL4, PMA, Hp, Ma, CSBG, SB, PKCzeta,,fibronectin, SDF1 | NK, DC |
||||||
alpha D, CD11d, ITGAD | human | 16p13.1-p11 | Sp1, Sp3 | ||||||||
beta 1, CD29, ITGB1 |
|
human, mouse, rat, bovine, Xl | 10p11.2 | L | VCAM1, MAdCAM1, TM4SFs, ADAM17 | PSI/VWA/TM | c-Myc, N-Myc, NF-kB, HOXD10, Pax6, | SCF,
TNFa,
GM-CSF,
PMA,
LPS,
MDP,
Ma,
HCV,
hypoxia,
cisplatin,
TIMP1 |
|||
beta2 , CD18 |
|
human, mouse, | 21q22.3 | L | PSI/VWA/TM | PU.1, NRF2, GABPs | TNFa,
LTa,
IL2,
IL4,
SCF,
MDP,
Hp,
Ma,
Mt,
Tc, HCV,
MVA |
induce NF-kB | |||
beta3 , CD61, GP3A, ITGB3 |
|
human, mouse, rat | 17q21.32 | 1 | ADAM15, alphaV, osteopontin | HOXA10,
Stat6,
ARNT2 |
b-glucan, D3,
IL4 |
calpain | |||
beta 4 , CD104, ITGB4 |
|
human, rat | 12q13.13 | laminins, alpha 6 integrin | GABPs | TGFb1,
SCF,
HIV
Vpr, SDF1 |
|||||
beta 5, ITGB5 | human, mouse, bovine | 3q21.3 | betaig-h3 | Sp1, Sp3, PU.1 | GM-CSF,
PMA,
TGFR1,
RA,
insulin,
IGF-II |
||||||
beta 6, ITGB6 | human, mouse, bovine | 2q24.2 | L | CD3, hypoxia | |||||||
beta 7 , ITGB7 | human, mouse | 12q13.13 | IL-2RIF, TGFb1, UVB, cisplatin | B, T, NK, DC |
|||||||
beta 8, ITGB8 | human | 7p21.3 | Fas, LPS, Ma, cisplatin | ||||||||
Tenascin-C, TNC, cytotactin, HXB | human, mouse, pig, chicken | 9q33 | 1 | EGFx14/FN3x15/FBG | TNFa, D3, HPV16 | epithelium, adipocyte |
|||||
LINK | CD44 |
|
human, mouse, rat, bovine | 11p13 | L | hyaluronan, aggrecan, collagen, IpaB | LINK/TM | Egr1, AP1, HMG-I, TEL, EWS/FLI-1, Hoxd10 | EGF, TNFa, RANKL, IL1b, IL2, IL5, IL10, M-CSF, GM-CSF, OPN, LPS, MDP, Ct, Ma, Ld, Lm, Mt, Tg, PMA, dsRNA,irrad, PKCs, Ca, BMP2, TIMP1, ROK, VDR, A2aR, estrogen, P2Y2 | ||
LYVE-1 | human, mouse | 11p15 | hyaluronan | LINK/CUB | Prox1, VEGF-C | lung, placenta |
|||||
TSG6, TNFAIP6 | human, mouse | 2q23.3 | 1 | 1 | hyaluronan | IL1, TNFa, G-CSF, LPS, MDP, LTA, Bm, Ld, Lm, Mt, Tg, AmB | neutrophil migration | ||||
stabilin 1, STAB1 |
human, mouse | 3p21.31 | hyaluronan | EGFx6/FAS1x2/EGFx5/FAS1x2/EGFx6/FAS1x2/EGFx5/LINK/FAS1/TM | bm, monocyte |
||||||
FELL, stabilin-2 | human, mouse | 12q23.1 | hyaluronan | EGFx6/FAS1x2/EGFx5/FAS1x2/EGFx6/FAS1x2/EGFx5/LINK/FAS1/TM | |||||||
aggrecan 1, AGC1 |
|
human, mouse | 15q26.1 | m | CD44 | IG/LINKx2/(SGXXSG)xn/CLECT | scleraxis,
SOX9;
ADAMTS5
|
||||
BEHAB, brevican, BCAN | human, mouse, Xl | 1q31 | 1 |
hyaluronan | IG/LINKx2/EGF/CLECT/CCP | brain |
|||||
chondroitin sulfate proteoglycan 2, versican, CSPG2 | human, mouse | 5q14.3 | IG/LINKx2/EGFx2/CLECT/CCP | Rb, | bm, monocyte, Wnt-3A, D3, irrad | ||||||
neurocan, CSPG3 | human, mouse | 19p12 | 1 | CD56, tenascin-C, Ng-CAM, , | IG/LINKx2/EGFx2/CLECT/CCP | brain |
|||||
BRAL1 | human, mouse | 1q21.2 | IG/LINKx2 | spinal cord, brain |
|||||||
CRTL1 | human, mouse, chick | 5q14.3 | cardiac |
group | name | apoptosis | species | locus | KO | 3D | binding partner | structure | TFs | upstream regulators | memo |
Tetraspanin (TM4) | CD9 |
|
human, mouse, rat, cat, bovine, pig, chicken, zebrafish, trout, salmon | 12p13 | L | CD63, CD81, CD82, PCG17, HLA-DR, -DM, DO, PKC | Tetraspanin | St PhoP, PMA, VEGF, UVB, D3, TCR, calcineurin | targets |
||
IgE Fc R b, CD20, MS4A1 | mediate/inhibit | human, mouse | 11q13 | Tetraspanin | irrrad | B |
|||||
ROM1, ROSP1 |
human |
11q13 | Tetraspanin | ||||||||
TM4-B |
human |
19p13.2 |
Tetraspanin | ||||||||
CD37 | human, mouse | 19p13-q13.4 | L | CD53, CD81, CD82, MHC-II, PKC | Tetraspanin | D3,
androgen,
OX40,
IL3,
IL13 |
B |
||||
CD53 |
|
human, mouse, rat | 1p13 | VLA4, HLA-DR, PKC, CD49d/CD29, | Tetraspanin | GnRH, IL3, Tg, Hp, Sp, PMA, androgen, camptothecin, cisplatin, staurosporine, paclitaxel, LiCl | B, T, NK, APCs |
||||
CD63 |
|
human, mouse, rat, rabbit, bovine, Xl | 12q12-q13 | VLA3, 6, HLA-DR, CD9, CD49d, CD29, CD81, CD82, AP3 | Tetraspanin | c-Myc | LPS, PACAP, IL5 | ||||
LOC90139 |
human |
11p11.2 |
|||||||||
CD82, kangai 1, KAI1, SAR2, ST6 |
|
human, mouse | 11p11.2 | CD4, CD63, HLA-DR, VLA 3,6, CD49d/CD29, PKC, HIV1 gp | Tetraspanin | p53, NF-kB | irrrad, BMP2 | ||||
CD81, TAPA1 |
|
human, mouse, rat, Ca, So, zebrafish | 11p15.5 | Leu13/CD19/CD21, HLA-DR, CD49d/CD29,CD4 | Tetraspanin | HIV Vpr | liver, lung |
||||
CD151, PETA-3 | human, monkey, mouse, rat | 11p15.5 | 1 |
a3b1, a4b1, a5b1, a6b1, a6b4, aIIbb3, integrins, PI4K, PKC | Tetraspanin | Ret |
|||||
PHEMX, TSSC6 |
human |
11p15.5 |
Tetraspanin | T, NK |
|||||||
TSPAN-1, tetraspan 1, NET-1 | human, mouse | 1p34.1 | Tetraspanin | p73 | epithelium |
||||||
TSPAN-2, tetraspan 2, TM4SF | human, mouse, rat, | 1p13.1 | Tetraspanin | TGFb |
bladder |
||||||
NET-2, TM4SF12 |
human, mouse | 7q31.31 | thyroid |
||||||||
tetraspan 3, TM4SF8, TSPAN-3 | human, mouse | 15q24.1 | Tetraspanin | TNFa,
RA,
B-DNA |
|||||||
TSPAN-5, tetraspan 5, NET-4, TM4SF9 |
human, mouse | 4q23 | Tetraspanin | CD71+ |
|||||||
DC-TM4F2 |
human |
10q23.1 |
Tetraspanin | ||||||||
CO-029, TM4SF3 | human, mouse, rat | 12q14.1-q21.1 | Tetraspanin | HOX11 | |||||||
NET-5 | human, mouse, rat | 12p13.33 | Tetraspanin | ||||||||
SAS | human, mouse, Xl, zebrafish | 12q13.3 | Tetraspanin | Ma | |||||||
NET-6, TM4SF13 |
human, mouse, rat | 7p21.3 | Tetraspanin | IL12 | DC |
||||||
MGC50844 |
human |
7q32.3 |
Tetraspanin | B, kidney |
|||||||
NET-7 | human | 10q22.1 | Tetraspanin | ||||||||
EMP2 | human, mouse, Xl | 16p13.2 | Tetraspanin | lung |
|||||||
UPK1A, uroplakin 1A, UPIA, UPKA |
human |
19q13.13 |
Tetraspanin | ||||||||
UPK1B, uroplakin 1B |
human |
3q13.3-q21 |
Tetraspanin | trachea |
|||||||
LOC116441, BC014339 | human | 3q24 | Tetraspanin | ||||||||
ILTMP, TM4SF4 | human, mouse | 3q25 | b1 | Tetraspanin | liver |
||||||
LOC116211, BC013113 | human | 3q29 | Tetraspanin | ||||||||
L6H, TM4SF5 | human, mouse, rat | 17p13.3 | Tetraspanin | liver |
|||||||
OCSP, oculospanin |
human |
17q25.3 |
Tetraspanin | ||||||||
CD231, TM4SF2, MXS1, A15 | human, mouse | Xq11.4 | Tetraspanin | FSH | brain |
||||||
TM4SF6 | human, mouse | Xq22 | Tetraspanin | ||||||||
tetraspanin 4,NAg2, TM4SF7 | human, mouse | 11p15.5 | Tetraspanin | ||||||||
TM4SF1, M3S1, TAAL6 | human, mouse | 3q21-q25 | Tetraspanin | NF-IL6, EWS/FLI-1 | TNFa, Ld, Lm, Mt | ||||||
SB134, FBX23, MGC14859 | human, mouse | 5q35.3 | Tetraspanin | ||||||||
RDS, RP7, AVMD, PRPH, AOFMD,
PRPH2 |
human |
6p21.2-p12.3 |
Tetraspanin | ||||||||
PMP22 (TM4) | PERP, PIGPC1, KCP1 | induce | human, mouse, rat | 6q24 | 1 | p53 | epithelium |
||||
BCMP1, TM4SF10 | human, mouse, frog | Xp11.4 | brain, spinal cord, adipocyte |
||||||||
LIM2, MP19 | human | 19q13.4 | |||||||||
podocalyxin |
CD34 | human, mouse, goat, pig, bovine, dog, cat | 1q32 | L-Selectin, CrkL | podocalyxin/TM | c-Myb, Ets2,NF-Y, Sp1, MZF1, NC-3A, | TGFb1,
TGFR1,
VEGF,
UVB,
ALK1,
TNFa |
bm |
|||
podocalyxin 1, PCLP, Gp200,
GCTM2, PODXL |
human |
7q32-q33 |
1 |
L-selectin,
ezrin,
NHERF2 |
podocalyxin/TM | WT1,
p53 |
kidney |
||||
endoglycan, PODLX2 |
human |
15 |
brain |
||||||||
mucin | mucin 1, MUC1 |
|
human, mouse | 1q21 | L | CD169 | simple repeats/SEA/TM | c-Myc | IFNg, TNFa, IL7, PMA, TACE, estrogen | lung |
|
mucin 2, MUC2 | human, mouse | 11p15.5 | L | Smad3/4,
Stat4,
NF-kB,
Sp1,
Sp3,
GATA5 |
TGFb, TNFa, IL1, IL9, EGF, PMA, RA, Hi, adenosine, VitA | ||||||
MUC3A | human | 7q22 | GATA5 | IL4,
IL6,
EGF,
PMA |
|||||||
MUC3B | human | 7q22 | |||||||||
MUC4 | human | 3q29 | VWD | Smad2/7,
PEA3,
GATA5 |
ErbB2,
TACE,
smoke |
trachea |
|||||
mucin 5AC, MUC5AC | human | 11p15 | H. pylori, |
CREB,
Sp1 |
TNFa,
IL1,
IL4/(-),
IL6,
IL9/(-),
IL13/(-),
IL17,
TGFb,
EGF,
PAF,
LPS,
Pa, RSV,
Rhinovirus,
chymase,
smoke,
DEX,
PGE2,
azithromycin;
TACE |
trachea |
|||||
mucin 5B, MUC5B | human, mouse | 11p15 | c-Myc | IL6, IL17 | trachea | ||||||
MUC6 |
human |
11p15.5-p15.4 |
VWD/ZnF/VWD//TILx2/extensin/CT |
TGFb |
|||||||
mucin 8, MUC8 | human | 12q24.3 | TNFa, IL1 | ||||||||
VWF | human, mouse | 12p13.3 | 1 | lung |
|||||||
sialophorin | sialophorin, SPN, leukosialin, CD43 |
|
human, mouse, rat | 16p11.2 | L | ICAM1, moesin, ezrin | ?/TM | Pur alpha, estrogen, Ma, Tc | targets |
||
sialomucin | CD164 | human | 6q21 | AraC | DC, placenta |
||||||
MIC2 | MIC2, E2, CD99 | human | Xpter-p22.32, Ypter-p11.2 | ?/TM | ribavirin | ||||||
lysosomal/ plasma membrane shuttling, scavenger |
CD68 | human, mouse | 17p13 | Lamp/TM | Elf1, PU.1, IRFs, AIRE | GnRH, Ct, Sp, HCV, EV71, Blimp1 | |||||
LAMP1 |
human |
||||||||||
LAMP2 |
human |
Xq24 | 1 | calcineurin | |||||||
LAMP, DCLAMP, TSC403, DC-LAMP,
LAMP3 |
human |
3q26.3-q27 |
LAMP/TM | LPS,
TNFa,
Fas,
CD40L |
|||||||
Syndecan | Syndecan 1, CD138 |
|
human, mouse, rat, frog, Dm | 2p24.1 | 1 |
Syndecan | WT1 | RANKL, thrombin, FGF2, PDGF-BB, TGFb1, IL1b, RA, D3 | epithelium, placenta, liver, shadding by Pa |
||
Syndecan 2, SDC2, SYND2, HSPG, HSPG1, fibroglycan | human | 8q22-q23 | TRRAP | thyroid, liver, adipocyte |
|||||||
Syndecan 4, amphiglycan, ryudocan, SDC4 | human | 20q12 | 1 | NF-kB | TNFa, IL1, PTH, VEGF, A2aR, Ye | ||||||
Syndecan 6 | human | RANKL | |||||||||
PSGL1, CD162, SELPLG | human | 12q24 | P-selectin, E-selectin | Syndecan/TM | G-CSF | ||||||
CD24 | CD24 |
|
human, mouse, rat | 6q21 | L | CD24 | AIRE | Sp,
Sm,
EV71,
aa
stavation, estrogen,
androgen,
PMX2,
La(NO3)3 |
thyroid, B, epithelium |
||
ECM1 |
ECM1 (human) |
1q21 |
activate
NF-kB |
||||||||
LAB | LAB, WBSCR5 | human, mouse, rat, | 7q11.23 | Grb2, PLCg1, PLCg2 | B, NK, monocyte, bm |
group | name | apoptosis | species | locus | KO | 3D | binding partner | structure | TFs | upstream regulators | memo |
selectin | L-selectin, LAM, LEU8, CD62L, SELL | (inhibit) | human, mouse | 1q23-q25 | L | carbohydrate ligands; GlyCAM-1, CD15su, CD34, PCLP, PSGL1, ELAM, nucleolin, CD162R | CLECT/EGF/Sushi x2/TM | STAT1, STAT3 | IL2,
IL3,
OX40,
Cp,
Ct,
Ma,
tax,
CsA/FK506,
staurosporine |
B, T, NK, APCs |
|
E-selectin, ELAM, CD62E, Sele | human, mouse | 1q22-q25 | L | L | carbohydrate ligands; ESL1,CD44, CD15s, PSGL1, CD65, LAM | CLECT/EGF/Sushi x6/TM | NF-kB, ATF2, ATF3, c-Jun,NFAT,A20, STAT6, Smads, | IL1, LPS, BLP,dsRNA, TNFa, LTa, TRAIL, radiation, IL4, IL1Ra, C5a, glucocorticoid, IFNg, TGFb, JNK, MEKK1, TMS, UVB, NO, flavonoids, cAMP, PPAR, PMA, tat | |||
P-selectin, GRMP, CD62P, Selp | human, mouse | 1q23-q25 | L | L | PSGL-1, CD15, CD15u, CD24, CD162 | CLECT/EGF/Sushi x9/TM | NF-kB, Bcl-3,STAT6, | TNFa, Fas, LPS, trauma,IL4, | MCP1 | ||
siglec, other | CD23, low aff. IgE RII, FCER2 | human | 19p13.3 | L | IgE, CD21, CD11b, CD11c | cc/CLECT | CBF1 | BAFF, IL4, Notch2, EBNA2, CD72, Blimp1 | B |
||
DC-SIGN, CD209 | human, mouse | 19p13 | high Man, Mt, CMV, EbolaV, SIV, HIV gp120, ICAM2, ICAM3 | CLECT | IL13 | lymph. DC |
|||||
LSIGN, DCSIGNR, CD209L | human | 19p13 | 1 | high Man, EbolaV | TM/CLECT | lymph. DC | |||||
SCGF | human | 19q13.3 | CLECT | TNFa | bm |
||||||
CD72, Lyb2 |
|
human | 9p11.2 | 1 | CD5, SHP1, CD100 | ITIM/TM/cc/CLECT | PU.1 | B |
|||
CD69, Leu23 |
|
human, mouse, rat, pig, bovine, | 12p13-p12 | L | 1 | G,Ha-Ras | TM/CLECT | AP1 | TNFa, IL2, IL7, IL12, IL15, TCR/CD5/CD28, PMA, IFNab, IFNg, GM-CSF, Thrombin, CpG, dsRNA, estrogen, PKC, IL4, LPS, Raf1,Vav2, Ha-Ras | B, T, NK |
|
MAFA, KLRG1 | human, mouse, rat, | 12p12-p13 | SHIP, Dok, Fc e RI, Man | ITIM/TM/CLECT | MHC-I, Tg | mast cell, CD8+ |
|||||
NKG2-(A, B), KLRC1, CD159a | human A,B | 12p13 | CD94, HLA-E, SHP1,2 | ITIM/TM/CLECT | NK |
||||||
NKG2-C, KLRC2 | human, mouse | 12p13.2-p12.3 | DAP12 | ITAM/TM/CLECT | NK |
||||||
KLRC4, NKG2-(D, F), KLR | human D, F, mouse, rat(NKR-P2), pig, | 12p13.2-p12.3 | MICs, DAP10, DAP12, UL16, | ITAM/TM/CLECT | L | IL2, IL4, IL5 | NK, T |
||||
NKG2H, KLRC3 | human E, H | 12p13 | ?/TM/CLECT | NK |
|||||||
Ly-49A, KLRA1, LY49L | human, mouse 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 ,13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 | 12p13-p12 | /TM/CLECT | TCF1 | B-DNA | ||||||
LLT1 | human | 12p13 | TM/CLECT | T |
|||||||
KLRD1, CD94 |
|
human | 12p13 | HLA-E(MHC-I), CD159a, DAP12 | CLECT | IL2, IL12, IL15, IL21, TCR, androgen | NK | ||||
NKR-P1A, CD161, KLRB1 | human | 12p13-p12 | CD1d, FcRgamma | TM/CLECT | IL2, IL12, IL21, TCR | NK, T |
|||||
dectin-1, CLECSF12 | human | 12p13.2-p12.3 | b-glucan | TM/CLECT | GM-CSF, IL4, IL10, IL13 | APCs, anti-Candida |
|||||
OLR1 | human | 12p13-p12 | Ox-LDL | cc/CLECT | Ye | ||||||
AICL, CLECSF2 | human | 12p13-p12 | TM/CLECT | IFNa/b, PMA | NK, APCs |
||||||
mincle, CLECSF9 | human, mouse | 12p13.32 | CLECT | NF-IL6 | LPS, TNFa, IL6, IL13, IFNg, hsp65 | ganglion |
|||||
CLL1 | human | 12p13.2 | TM/CLECT | ||||||||
DLEC, BDCA2, CLECSF11 | human | 12p13.2-p12.3 | CLECT | ||||||||
KLRF1, NKp80 | human | 12p12.3-13.2 | ITIMx2/TM/CLECT | NK |
|||||||
CLEC1 | human | 12p13.2 | TM/cc/CLECT | ||||||||
CLECSF1 | human | 16q23 | CLECT | ||||||||
MDL1, CLECSF5 | human | 7q33 | DAP12 | ITIM/TM/CLECT | myeloid | ||||||
CLEC6, CLECSF8 |
human, mouse | 12p13.32 | TM/CLECT | NRF2 | |||||||
DCIR, LLIR, CLECSF6 | human | 12p13 | ITIM/TM/CLECT | IL13 | APCs |
||||||
CLEC6A, CLECSF10 |
human |
12p13 |
LPS, Sm | ||||||||
CLEC2 | human | 12p13 | CLECT | FKHR | Akt | ||||||
langerin/CD207 | human, mouse | 2p13 | TM/cc/CLECT | GM-CSF, TGFb1, IL4 | |||||||
REG1A, PSPS | human, mouse | 2p12 | pancreas |
||||||||
REGL, PSPS2, REG I beta | human | 2p12 | CLECT | pancreas |
|||||||
REG-IV | human | 1q12-q21 | CLECT | pancreas | |||||||
tetranectin, TNA | human, mouse | 3p22-p21.3 | 1 | sulfated PS | CLECT | lung |
|||||
HML2, CLECSF13 | human | 17p13.2 | Gal/GlcNAc | TM/cc/CLEST/YENF | |||||||
ASGR1 | human, mouse | 17p13.2 | asialoglycoprotein | TM/CLECT | liver, preDC |
||||||
ASGR2 | human, rat | 17p13.1 | asialoglycoprotein | TM/CLECT | liver, preDC | ||||||
BIMLEC | human | 2q24.2 | CLECT/TM | APCs |
|||||||
chondrolectin, MT75, PRED12, CHODL | human, mouse, rat | 21q11.2 | CLECT/TM | testis germ cell |
|||||||
ManR | MRC1 | human, mouse | 10p13 | RICIN/FN2/CLECTx8/TM | PPARg | IL13, HCV, D3 | |||||
ENDO180, MRC2 | human, mouse | 17q22 | N-GlcNAc, MMP13 | RICIN/FN2/CLECTx8/TM | |||||||
DEC205, Ly75 | human, mouse | 2q24 | RICIN/FN2/CLECTx10/TM | Fas,
camptothecin , LPS, hsp65, D3 |
Thy |
||||||
PLA2R1 | human | 2q23-q24 | PLA2 | RICIN/FN2/CLECTx8/TM | |||||||
MBL2, MBP1, | human | 10q11.2-q21 | L | mannose | CLECT | TNFa, KF1B | |||||
PRG2 | human | 11q12 | CLECT | s. muscle |
|||||||
PRG3, MBPH | human | 11q12 | CLECT | IL5 |
bm |
||||||
anchor | thrombomodulin, THBD |
human, mouse, rat, rabbit, bovine, | 20p11.2 | 1 | thrombin | CLECT/EGFx6/TM | 1 | RA, estrogen,cAMP | |||
C1QR, C1QR1 |
human, mouse | 20p11.21 | C1q | CLECT/EGFx6/TM | EV71, camptothecin | ||||||
TEM1, endocialin | human, mouse | 11q13 | CLECT/EGFx3/TM | adipocyte |
|||||||
collectin | PSAP, SFTP1, SPA1, SFTPA1 |
|
human, mouse | 10q22.2-q23.1 | 1 | TLR2 | Collagen/CLECT | NF-kB, IL-1, TTF1, DEX, cAMP, CBP/p300, SRC1 | |||
SPA2, SFTPA2 | human | 10q22-q23 | Collagen/CLECT | ||||||||
CL-L1, COLEC10 | human | 8q23-q24.1 | Collagen/CLECT | ||||||||
MGC3279 | human | 2p25.3 | Collagen/CLECT | ||||||||
SP-D, PSP-D, SFTP4, SFTPD | human | 10q22.2-q23.1 | 1 | LPS-O, LTA, PGN | Collagenx2/cc/CLECT | TTF1,
NF-ATs |
|||||
scavenger | SRCL, CL-P1, COLEC12 | human | 18pter-p11.3 | TM/ccx3/Collagenx2/CLECT | |||||||
attractin | attractin, MGCA | human | 20p13 | zi | EGF/CUB/EGF/Kelchx4/PSIx3/CLECTPSIx2/EGF/TM | MVA | |||||
DGCR2 | DGCR2 | human | 22q11.21 | LDL/CLECT/VWC/TM | |||||||
Dm | CG9134, G12111, CG15358, CG7763, CG9978, CG2839, CG15818, CG9095, Lectin-galC1-P1, Gal-lectin, lectin-21Ca, lectin-24A, lectin-24Db, lectin-28C, | Dm | |||||||||
Ce | ZK1193.2, T03F1.10, F40G9.10,B0218.8.p, W04E12.8, W04E12.6, K02F3.5, C14A6.1, B0218.6, T19E7.1, F47C12.2, F52E1.2, C54C8.7, E03H4.10, | Ce | |||||||||
lectin | MR60, ERGIC53, LMAN1 | human, mouse, rat | 18q21.3-q22 | lectin/cc/TM | Sp | ||||||
galectin | galectin 1, LGALS1 |
|
human, mouse, rat, bovine, sheep, chicken, Xl, zebrafish, Dm, Ce | 22q13.1 | L | galectin | ErbB2, Mt, estrogen, TIMP1 | epithelial, activate
NF-kB |
|||
galectin 2, LGALS2, MAC2 | human, mouse, rat, | 22q13.1 | LTa |
galectin | AIRE | IFNa/b | APCs |
||||
galectin 3, LGALS3 |
|
human, mouse, rat, rabbit, | 14q21-q22 | 1 | galectin | Ets1 | TNFa, HCV, TRAF2/TRAF5, TIMP1 | CD71+, APCs |
|||
galectin 4, LGALS4 | human, mouse | 19q13.13 | galectin | liver |
|||||||
galectin 6, Lgals6 | mouse | Hoxd10 | intestine |
||||||||
galectin 7, LGALS7 | human, mouse, rat | 19q13.13 | galectin | Brn3a |
epithelium, skin, tongue |
||||||
galectin 8, PCTA1, LGALS8 | human, mouse, rat | 1q42-q43 | galectin | CREB,
AP1,
LPS |
APCs, B, T, NK |
||||||
ecalectin, galectin 9, LGALS9 | human, mouse, rat, | 17q11.1 | galectin | IFNa/b,
IL3,
IL12,
HCV,
staurosporine |
APCs, bm, activate NF-kB |
||||||
galectin 12, LGALS12 | human, mouse | 11q13 | galectin | adipocyte |
|||||||
galectin-13, PP13, PLAC8 | human | 19q13.1 | galectin | STAT4 |
IL12 | placenta |
|||||
Grifin | mouse, rat | galectin | eye |
||||||||
fibrinogen-related | ficolin 1, FCN1 | human, mouse, rat | 9q34 | collagen/FBG | APCs |
||||||
ficolin 2, p35, L-ficolin, FCN2 | human, mouse, rat | 9q34 | GlcNAc | collagen/FBG | liver |
||||||
ficolin 3, H-ficolin, Hakata antigen, FCN3 | human | 1p35.3 | GalNAc, GlcNAc | FBG | liver, lung |
Saccharide Transferases
group | name | apoptosis | species | locus | KO | 3D | structure | upstream regulators | memo |
glycosyltransferases | a(1,2), FUT1, Hh | human, mouse, rat, bovine | 19q13.3 | 1 | glycosyltransferases | c-Myc | endothelium, CD71+ |
||
a(1,3), FUT2, Se | human | 19q13.3 | L | glycosyltransferases | |||||
FUT3, Les | human | 19p13.3 | glycosyltransferases | ||||||
a(1,3), FUT4, CD15 | human, mouse, rat, bovine | 11q21 | glycosyltransferases | granulocytes, bm |
|||||
a(1,3), FUT5 | human, bovine | 19q13.3 | glycosyltransferases | heart |
|||||
a(1,3), FUT6 | human | 19p13.3 | glycosyltransferases | kidney |
|||||
a(1,3), FUT7 | human, mouse, | 9q34.3 | glycosyltransferases | DC |
|||||
a(1,6), FUT8 | human | 14q24.3 | glycosyltransferases | ||||||
a(1,3), FUT9 | human, mouse, rat, bovine | 6q16 | glycosyltransferases | ||||||
a(1,3), FUT10 | human, bovine | 8p12 | glycosyltransferases | ||||||
MGC33202 | human, mouse, rat | 10q22.3 | |||||||
galactosyltransferase | B4GALT1 | enhance | human, mouse, Dm, Ce | 9p13 | L | 1 | galactosyltransferases | TNFa, FAK, cycloheximide | |
B4GALT2 | human, mouse, bovine | 1p34-p33 | |||||||
B4GALT3 | human, mouse | 1q21-q23 | DC |
||||||
B4GALT4 | human, mouse | 3q13.3 | NK |
||||||
B4GALT5 | human, mouse | 20q13.1-q13.2 | |||||||
B4GALT6 | human, mouse, rat | 18q11 | (brain) |
||||||
B4GALT7 | human, mouse | 5q35.2-q35.3 | |||||||
chondroitin synthase 1, CHSY1 | human, | 15q26.3 | placenta |
||||||
chondroitin synthase 2, CHSY2 | human, | 5q31.1 | |||||||
chondroitin beta1,4 N-acetylgalactosaminyltransferase, ChGn | human | 8p21.3 | thyroid |
||||||
GALNACT-2 | human | 10q11.21 | |||||||
FLJ25045 | human | 11p15.5 | |||||||
FLJ40362, B4GalNac-T3 |
human | 12p13.33 |
Complement and Related Proteins
group | name | apoptosis | species | KO | locus | structure | binding partners | 3D | gene regulators | memo |
C1q | C1q alpha |
|
human, mouse | 1 | 1p36.3-p34.1 | Collagen/C1q | IG,C1q, C1s, C1r, fibronectin, PTX3 | NRF2, CSV-B3, Tc | heart, lung |
|
C1q beta | human, mouse, rat | 1p36.3-p34.1 | Collagen/C1q | Tc | heart, lung | |||||
C1q gamma | human, mouse | 1p36.11 | Collagen/C1q | heart, lung | ||||||
C1QTNF1, GIP, CTRP1, ZSIG37 | human, mouse | 17q25.3 | Collagen/C1q | s. muscle |
||||||
C1QTNF2, CTRP2, zacrp2 | human | 5q33.3 | Collagen/C1q | |||||||
C1QTNF3, CTRP3, CORS26, | human | 5p13-p12 | ||||||||
C1QTNF4 | human | 11q11 | brain |
|||||||
C1QTNF5, CTRP5 | human, mouse | 11q23.3 | lung |
|||||||
C1QTNF6, CTRP6, ZACRP6 | human | 22q13.1 | ||||||||
C1QTNF7, CTRP7, ZACRP7 | human, mouse | 4p16-p15 | ||||||||
C1ql | mouse | brain |
||||||||
adiponectin, APM1, ACRP30, GBP28 | human, mouse, rat | 3q27 | Collagen/C1q | ADD1,
SREBP1c,
PPARg,
IL6 |
adipocyte |
|||||
C1r | C1r | human, mouse | 12p13 | CUB/EGF/CUB/Sushix2/Trypsin | 1 | NRF2, IFNa, FSH, HCV, camptothecin, ribavirin | liver, adipocyte |
|||
C1s | human, mouse (& B) | 1 | 12p13 | CUB/EGF /CUB/Sushix2/Trypsin | 1 | TNFa, IFNg, VEGF, LPS | liver, adipocyte, cleave C2, C4 |
|||
MASP1, MASP, RaRF, CRARF, PRSS5, CRARF1 |
human, mouse, rat | 1 | 3q27-q28 | CUB/EGF /CUB/Sushix2/Trypsin | MBL | liver |
||||
MASP2 | human, mouse | 1 | 1p36.3-p36.2 | CUB/EGF /CUB/Sushix2/Trypsin | MBL | liver, cleave C2, C4 | ||||
C1RL, C1r-like, C1rlp, LOC51279 | human, mouse | 12p13.31 | CUB/Tripsin | STAT3, STAT5B, NF-IL6, Smads, IL1, IL6, TNFb, DEX, | liver, PBL |
|||||
haptoglobin, HP | human | 16q22.1 | CUB/Tripsin | hemoglobin | liver |
|||||
C2 | C2 | human, mouse, rat, | 1 | 6p21.3 | Sushix3/VWA/Trypsin | CD3/CD28, IL1, IFNa, IFNg | liver |
|||
Factor B, BF | human, mouse, frog, zebrafish | 6p21.3 | liver |
|||||||
C3 | C3 | human | L, d | 19p13.3-p13.2 | A2M/ANATO/A2M/NTR | factor B, (CR1, CR2) | 3d | NF-kB, EWS/FLI-1, TNFa, IL1, IL13, RA, LPS, hsp65, Pg, Hp, HCV, HOXD3, GCSF, IL10, Stat4, calcineurin | liver |
|
C4a | human | L | 6p21.3 | A2M/ANATO/A2M/NTR | p53, EV71 | liver |
||||
C4b | human | 6p21.3 | A2M/ANATO/A2M/NTR | NF-kB, PMA, Ct | liver |
|||||
C5 |
|
human | L | 9q32-q34 | A2M/ANATO/A2M/NTR | 5a, | liver, targets | |||
C6 | C6 | human, mouse, rat, Xl | L | 5p13 | TSP1x2/LDLa/MACPF/TSP1/Sushix2/FIMACx2 | liver |
||||
C9 | human, mouse, rat, rabbit, fugu | 5p13 | TSP1/LDLa/MACPF/TSP1/Sushix2/FIMACx2 | CD59 | MDP | liver |
||||
C7 | human, pig | 5p13 | /LDLa/MACPF/TSP1/Sushix2/FIMACx2 | adrenal, ovary, lymph. |
||||||
C8 alpha | human, rabbit | 1p32 | TSP1/LDLa/MACPF/TSP1 | CD59 | liver |
|||||
C8 beta | human, mouse | 1p32 | TSP1/LDLa/MACPF | liver |
||||||
C8g | C8 gamma | human | 9q34.3 | Lipocalin | liver |
|||||
perforin | perforin, cytolysin | human, mouse, rat | L | 10q22 | MACPF/C2 | C5a, | IL2, IL4, 4-1BBL, CD30, Notch, Sd, RA, Progesterone, PKC, STATs, Ets, Sp1, CsA/FK506 | |||
C1qBP | C1qBP, HABP1 | human | 17p13.3 | MAM33 | C1q,SF2 | preB |
||||
7TM | C3aR | human, mouse, rat | 1 | 12pter-p13.31 | 7TMx2 | C3a | GCSF,
LPS,
EV71,
IL13 |
NK, preDC |
||
C5R1, C5a ligand, CD88 | enhance | human, mouse, rat | 1 | 19q13.3-q13.4 | 7TM | 1 | RANTES, LPS, IL6, IFNg | preDC, targets | ||
Sushi | MCP, CD46 | human, mouse | 1 | 1q32 | Sushix4/TM | C3b, C4b, measles virus, HHV-6 gH | 1 | Tr1 | ||
CD35, CR1 | human | L | 1q32 | Sushix30/TM | CD3b, C4b, IgG, IgD, IL2, malaria | 1 | IL2, IL4, IL8, TNFa, LTa, BAFF, AML1, hypoxemia, D3 | induce NF-kB | ||
DAF, CR, CD55 | human | 1 |
1q32 | Sushix4 | CD97, echovirus 7, EV70, CB3, LPS | FKHRL1, PMA, EV71 | B, myeloid |
|||
CR2, CD21 | inhibit | human | L | 1q32 | Sushix15 | C3d, CD23, CD19/CD81 | NF-kB, c-Myc, BAFF, Hp, Mt, Sp, Sp1, USF1 | tonsil, lymphnode, B |
||
C4BPalpha | human | 1q32 | Sushix8 | Protein S, CD40 | HNF1, androgen, NF-kB, TNFa, IL1, IL6,Galectin-7 | liver, lung |
||||
C4BPbeta, C4BPB |
human | 1q32 | Sushix3 | HNF-3, NF-I, ErbB2 | liver |
|||||
Factor H, HF1 | human | 1q32 | Sushix20 | C3 convertases | L | IL10/LPS | liver |
|||
FHR1, CFHL, HFL1 |
human | 1q31-q32.1 | Sushix5 | liver |
||||||
FHR2, HFL3 | human | 1q31-q32.1 | Sushix4 | liver |
||||||
FHR3 | human | 1q31-q32.1 | Sushix5 | liver |
||||||
FHR4 | human | 1q31-q32.1 | Sushix5 | liver |
||||||
FHR5 | human | 1q22-q23 | Sushix8 | liver |
||||||
Factor I | Factor I, IF |
human | 4q25 | KAZAL/SR/LDLax2/Trypsin | liver |
|||||
LU | CD59, protectin, MIC11 | human, mouse, rat, rabbit, viruses | L | 11p13 | LU | CD2, C8alpha, C9, Hp | L | p53, TNFa, CREB, STRA13, androgen, PMA, Tprim., IFNa,PDGF, | ||
ARS, component B | 8q24.3 | LU | tongue |
|||||||
E48, LY6D |
human | 8q24-qter | LU | Hoxc8,
Hp , D3 |
tongue |
|||||
PSCA | human | 8q24.2 | LU | PMA | prostate |
|||||
G6C | human | 6 | LU | |||||||
G6E | human | 6p21.3 | LU | |||||||
SLURP-2, LYNX1 | human | 8q24.3 | LU |
Antibacterial peptides (partial list)
group | name | species | locus | KO | gene | 3D | gene regulators | memo |
a defensin | a1/HNP-1, DEFA1 |
human | 8p23.2-p23.1 | C/EBP,
c-Myb,Nef,
TCR/CD3/CD28,
IL15,
RA,
Nod2 |
neutrophil, processed by matrilysin | |||
a3/HNP-3, DEFA3 | human, | 8pter-p23.3 | IFNa | neutrophil | ||||
a4/Def.4,,DEFA4 | human | 8p23 | IFNa |
neutrophil | ||||
a5/Def.5, HD-5, DEFA5 |
human | 8pter-p21 | neutrophil | |||||
a6/Def. 6, DEFA6 | human | 8pter-p21 | neutrophil | |||||
b defensin | b1, DEFB1 |
human | 8p23.2-p23.1 | kidney, liver, prostate, salivary gland, constitutive | ||||
b2, hBD-2, DEFB4, SAP1, DEFB102 | human | 8p23.1-p22 | 1 | L | bacteria, Hp, LPS, FliC,NF-kB,IL-1, IL17, TNFa | salibarygland, kidney, tongue |
||
DEFB103A, HBD3, HBP3, DEFB3, HBD-3, HBP-3, | human | 8p23 | corticosteroids | |||||
DEFB104, DEFB4, DEFB-4 |
human |
8p23 |
||||||
DEFB105, BD-5, DEFB-5 |
human |
8 |
||||||
DEFB106, BD-6, DEFB-6 |
human |
8p23-p22 |
||||||
DEFB107, DefB-7 |
human | 8p23-p22 |
||||||
DEFB108, DefB-8 |
human | 8p23-p22 |
||||||
SPAG11, EP2, HE2, EP2C, EP2D | human | 8p23-p22 | ||||||
DEFQ1, Def-theta1 |
human |
8p23.1 |
bone marrow, lymph node, thyroid |
|||||
DEFB118, ESC42, DEFB-18 |
human |
20q11.1-q11.22 |
testis |
|||||
DEFB119, DEFB-19, DEFB-20,
DEFB120 |
human |
20q11.1 |
testis |
|||||
DEFB123, DefB-23 |
human |
20q11.1 | ||||||
DEFB124 |
human |
20q11.1 |
testis |
|||||
DEFB125 |
human |
20p13 |
||||||
DEFB126 |
human |
20p13 |
testis |
|||||
DEFB127 |
human |
20p13 |
||||||
DEFB129 |
human |
20p13 |
||||||
UNQ827, KFLL827, DEFB32 |
human |
20p13 |
||||||
cathelicidin | cathelicidin, FALL39, CAP18, CAMP |
human,mouse | 3p21.3 | 1 | St, LPS, IFNa, IL5, IL-6, RA | bone marrow, PMN, processed by proteinase-3 | ||
hepcidin | hepcidin, HAMP, LEAP1 | human, mouse | 19q13 | 1 | 1 | iron, C/EBPa, USF2, hypoxia | liver |
One-line review of
Antimicrobial peptides of vertebrates by Yang et al. (Annu Rev Immunol 2004), by Ganz & Lehrer (Curr Opin Immunol 1998)
IL8 Family Chemokines and
Their Receptors
group | proposed | name | ligand/receptor | apoptosis | species | gene | locus | KO | 3D | gene regulators | memo |
CC | SCYA1 | I309, CCL1 |
CCR8 | human, mouse | 17p13.2 | 1 | TCR,
IL12, IFNa, IL31 |
||||
CCL2 | MCP1, MCAF, SCYA2 | CCR2 |
|
human, mouse, rat, bovine, rabbit,pig,dog, | 1 | 17q11.2-q21.1 | L | 1 | NF-kB,
Sp1,
C/EBPs,
AP1,
EGR1,
Bcl6,
PDX1,
Hoxc8,
NRF2,
EWS/FLI-1,
TNFa,
LTa,
TRAIL,
Fas,
RANKL,
IL1,
IL4,
IL13,
IL17,
IFNa,
IFNg,
GM-CSF,
IL1b/IFNg,IFNk,
PDGF-BB,
RA,
PMA,
AgII,
C5a,
EP4,
VIP,
PACAP,
insulin,
Resistin,
estrogens,
Wnt1,
Akt/PKB,
IKKs,
p38,
PLC,
LPS,
BLP,
LTA,
PGN,
KF1B,
MDP,
OX-CA,
Bm,
Ec,
St,
Sa,
Lm,
Mt, Pg, Tc, TBhsp70,
BCGhsp65,
flagellin,
BCG,
Cp,Hp,
Pa,
Tg,
dsRNA,
HCV,
RSV,
AdV,
HHV8,
UVB,
shear
stress, RANTES,
SCF,
VEGF,
plasmin,
p38, Cannabinoid,
doxorubicin,
Alprazolam,
Bmp6,
Bmp7,
estrogen,
PGE2,
Gab2,
EP4,
BMP2,
IL10,
AgII,
IKKs,
SOCS1 |
||
CCL3 | MIP1a, LD78, SCYA3 | CCR1, 5 | inhibit/promote | human, mosue, rat, chicken | 17q11-q21 | L | 1 | NF-kB, C/EBPs, Ets2, p53, PPARg, IL3, IL2, IL6, IL15, GM-CSF, Ets, serum, TNF, FasL, Fas, RANKL, CD40, IFNk, XNA,VIP, PACAP, LPS, PGN, MDP, TBhsp70, LTA, b-glucan, BCGhsp65, BCG, Ec, Ld, Lm, Ma, Mt, Sa, Sm, St, g-irrad, NO., PMA, FceRI, CD3/28, BCR, CD43,Nef, CD3&IL2, Bcl6, RANTES, RA, D3, PGE2, Rac2, AmB, camptothecin, ribavirin | |||
CCL3L1 | LD78-beta | human | 17q11.2 | PMA | |||||||
CCL4 | MIP1b, ACT2, LAG1, SCYA4 | CCR5 |
|
human, mouse, rat, rabbit | 17q21 | L | CREB, LPS, CD40, TNF, RANKL, FasL, IL1, IL3, IL10, IL2, IL12, IL15, IL31, GM-CSF TCR/CD3/CD8/CD28, BCR, XNA, PMA, CD43, MIP3, Subst.P, CD3&IL2, MDP, flagellin, b-glucan, BLP, Bm,,Hi, Ld, Lm, Ma, Mt, Sa, Sp, g-irrad., HCV, Nef, dsRNA, CpG, OX-CA, Cannabinoid, CsA, estrogen, RANTES, SCF, D3, PGE2, AmB, ribavirin | ||||
CCL4L1 |
LAG1, LAG-1, SCYA4L, AT744.2 |
human |
17q12 |
||||||||
CCL5 | RANTES, SCYA5 | CCR1,3,5 | inhibit/promote | human, mouse,rat, bovine | 1 | 17q11.2-q12 | 1 | L | NF-kB, IRF1, IRF3, IRF7, AP1, AIRE, RFLAT1, HSF1, IL1, IL2, IL17, TNF, CD40, CD8/28, LTa, RANKL, IFNs, IL12, TCR, M-CSF, GM-CSF, VIP, PACAP, LPS, PGN, MDP, LTA, Bm, Hp, Ld, Lm, Mt, Tg, Ct, Ma, Mt, Pg, Yp, dsRNA, EV71, VLP, CD28, BCR, IFNg, IL17, SCF, EP4, BRCA1, PMA, RSV, IKKs, IKKi, TBK1, TAK1, JNK, CFTR, DEX, estrogen, androgen, D3, EP4, IKKs | targets | |
CCL6 | c10, MRP-1, SCYA6 | mouse | Hf ,Sm | ||||||||
CCL7 | MCP3, SCYA7 | CCR1,2,3 | human, mouse,rat | 17q11.2-q12 | L | NF-kB,
Hoxc8,
b1-integrin, b-catenin, TRAIL,
IL1,
IL17,
TNFa,
RANKL,
VEGF,
PMA,
Bcl6,
insulin,
NO,
BLP,
Bm,
Ld,,
Lm,
Mt,
Pg, Sp,
Tg,
VLP,
DEX,
BMP2,
IL10,
IKKs,
camptothecin,
cantharidin,
ALA,
SOCS1 |
|||||
CCL8 | MCP2, SCYA8 | CCR3 | human,mouse, pig,bovine | 17q11.2 | 1 | IFNg,
IL1,
RANKL,
LPS,
PGN,
Lm,
Mt,
Tg,
VLP |
|||||
CCL9 | MIP-1 gamma, SCYA9 | mouse | NF-kB,
NRF2,
PPARg,
AIRE,
TNF,
RANKL,
IL1,
LPS,
D3 |
||||||||
CCL11 | eotaxin 1, AI1, SCYA11 | CCR3 | human, mouse, rat, pig, house,bovine | 17q21.1-q21.2 | L | L | NF-kB, STAT6, IL13, TNFa, IL1b, IFNg, IL4, IL9, IL25, LPS, PGN, LTA, Lm, Mt, VLP, glucocorticoid, TGFb1, estrogen, HuR, A2aR | ||||
CCL12 | MCP5, eae7, TCA-3, SCYA12 | mouse | LPS, CpG, Lm, IFNabR1, TRIF | ||||||||
CCL13 | MCP4, NCC1, SCYA13 | CCR2,3 | human | 17q11.2 | TNFa,TRAIL, IFNg, IL4, PGN, glucocorticoid, RA | ||||||
CCL14 | NCC2, SCYA14 | CCR1 | human | 17q11.2 | 1 | IFNa, TNFa, c-Myc, IL1,ALK1, TGFR1 | |||||
CCL15 | MIP1d, NCC3, leukotactin, MIP5, SCYA15 | CCR1,3 | human | 17q11.2 | ALA | ||||||
CCL16 | NCC4, SCYA16 | CCR1 | human | 17q11.2 | SCF | ||||||
CCL17 | TARC, SCYA17 | CCR4 | human, mouse | 16q13 | TNFa, IFNg, IL10, IL25, IL31, SCF,LPS, Lm, Mt, Tg, BMP2 | ||||||
CCL18 | PARC, AMAC1, DC-CK1, SCYA18 | human | 17q11.2 | IL10, D3, TCR/CD3, LPS, Ca,Mt, Sa, influenza v, TNFa, CD40L,IFNg, | |||||||
CCL19 | MIP3b, exodus-3, CCL19, ELC, SCYA19 | CCR7 | human, mouse | 9p13 | IL31, Ma,
LPS |
||||||
CCL20 | MIP3a, exodus-1, CCL20, Larc, SCYA20 | CCR8 | human, mouse, rat | 2q33-q37 | NF-kB,
Sp1,
ESE1,
EWS/FLI-1,
IL1,
TNFa,
LTb, PMA,
LPS,
PGN,
Bm,
Ld,
Lm,
Mt,
Tg,
Ye,
flagellin,
UVB,
hypoxia,
D3,
MEK1,
camptothecin,
ALA |
||||||
CCL21 | SLC, exodus-2, SCYA21 | CCR7 |
|
human, mouse(a,b,c) | 9p13 | SCF, Prox1, PMA | |||||
CCL22 | MDC, STCP-1, SCYA22 | CCR4 | human, mouse | 16q13 | IL1b, SCF, IL12, IL13, IL31 | ||||||
CCL23 | MPIF1, Ckb-8, SCYA23 | CCR1 | human | 17p13.2 | 1 | IL31, Mt, LPS | |||||
CCL24 | eotaxin 2, MPIF2, SCYA24 | CCR3 | human, mouse | 7q11.23 | L | LPS, IL-4 | |||||
CCL25 | Teck, SCYA25 | CCR9 |
|
human, mouse | 19p13.2 | VDR, Egr1, AIRE | |||||
CCL26 | eotaxin 3, SCYA26 | CCR3 | human | 7q11.2 | STAT6,IL4,
IL13,
TGFb |
||||||
CCL27 | CTACK, ILC, ALP, Eskine | CCR10 | human, mouse | 9p13 | TNFa, NRF2, PMA | ||||||
CCL28 | CCL28 | CCR3, CCR10 | human, mouse | 5 | |||||||
CXC | CXCL1 | Groa, Gro1, MGSA, SCYB1, KC |
CXCR2 | human, mouse | 4q12-q13 | 1 | NF-kB, NF-IL6, Sp1, HMG-I, C/EBP, PPARg, EWS/FLI-1, TRAIL, TNFa, IL1, IL17, IL31, XNA, VEGF, insulin, LPS, PGN, KF1B, MDP, BLP, LTA, Ec, Ld, Lm, LLO, Mt, Pg, St, Sa, Tg, Ye, hsp70, hsp65, flagellin, BCG, AdV, UVB, HHV8, VLP, BMP2, IL10, Wnt3a, | ||||
CXCL2 | MIP2, MIP2a, Grob, Gro2, SCYB2 | CXCR2 | human, mouse | 4q12-q13 | 1 | NF-kB, c-Myc, PPARg, EWS/FLI-1, IL1, IL17, TNFa, FasL, RANKL, XNA, PMA, C5a, GM-CSF, LPS, BLP, PGN, KF1B, MDP, LTA, R848, Bm, Cd, Ct, Ec, Hp, Ma, Mt, Ld, Lm, Pg, Sa, Sd, St, Tg, Ye, flagellin, HCV, RSV, dsRNA, VLP, FVIIa, DEX, NO, hypoxia, Subst.P, VIP, PACAP, UVB, estrogen | |||||
CXCL3 | MIP2b, Grog, SCYB3 | CXCR2 | human | 4q21 | IL1, TNFa, LPS, PGN, MDP, LTA, Bm, Hp, Ld, Lm, Mt, St, Tg, Ye, flagellin, HHV8, UVB, DEX, D3 | ||||||
CXCL4 | PF4, SCYB4 | inhibit | human,
mouse |
4q12-q13 | Ets1, GATA1, PDX1, IL6 | ||||||
PF4V1 |
PF4A, CXCL4V1, PF4-ALT, SCYB4V1 |
human |
4q12-q21 |
||||||||
CXCL5 | ENA78, SCYB5, LIX |
CXCR2 | human,
mouse |
4q12-q13 | AIRE,
GCSF,
IL1,
IL17,
TNF,
BMP2,
LPS,
hsp65,
Hp,
Hf, Mt, Pg, VLP |
induces NF-kB | |||||
CXCL6 | GCP2, SCYB6 | CXCR1,2 | human | 4q12-q13 | EWS/FLI-1, IL1, TNFa, BAFF, IFNg, PGN, DEX | ||||||
CXCL7 | proPBP, CXCL7, (CTAP3, TGb, NAP2, TC1, TC2), SCYB7, PPBP | CXCR2 | human,
mouse |
4q12-q13 | PU.1,
IL1b/TNFa,
Pg |
||||||
CXCL8 | IL8, see ILs | CXCR1, 2 | PGN,
IL1 |
||||||||
CXCL9 | MIG, SCYB9 | CXCR3 | human,
mouse |
4q21 | STAT1, NF-kB, CBP, IFNg, B-DNA, PPARg, TNF, EP4, IL12, IL10, Hf, Hp, Lm, Mt, Pg, Tc, Tg | ||||||
CXCL10, SCYB10 | IP10, INP10, Mob1 | CXCR3 |
|
human, mouse | 4q21 | L | NF-kB, Hoxc8, IL1, TNF, LTa, Fas, IFNa, IFNb, IFNg, IL4, VEGF, Subst.P, EP4, cholecystokinin, CpG, LPS, BLP, Ec, Pg, St, Sa, Lm, Mt, Tg, TBhsp70, BCGhsp65, BCG, dsRNA, HCV, MV, AdV, HHV8, VLP, PGE2, estrogen, STAT1, PPARg1, IFNabR1, TRIF, MyD88 | ||||
CXCL11 | IP9, ITAC, CXCL11, SCYB11 | CXCR3 | human | 4q21.2 | TNFa, IFNa/b, IFNg, PPARg, LPS, B-DNA, Mt, Tg, TRIF | ||||||
CXCL12 | SDF1, pre-B, CXCL12, SCYB12 | CXCR4 | induce/inhibit | human | 10q11.1 | L | L | NF-kB, TNFa, CD8/28, Wnt1, Hf, Hi, VLP, IL3, ER, PTEN, IKKs, estrogen | targets | ||
CXCL13 | BLC, BCA1, CXCL13, SCYB13 | CXCR5 | human | 4q21 | L | A2aR,
LPS,
Hp,
IL10 |
|||||
CXCL14 | BRAK, SCYB14 | human, mouse | 5q31 | AIRE,
HCV,
estrogen |
|||||||
CXCL15 | Lungkine | mouse | 1 |
||||||||
CXCL16 | SRPSOX | CXCR6 | human, mouse | 17p13 | PGN,
IFNg,
TNFa,
Pg |
induce NFkB | |||||
XCL1, SCYC1 | XCL1, SCM1, SCM1a, lymphotactin | XCR1 | promote | human, mouse | 1q21-q25 | CsA/FK506, CD3&IL2, PMA, VLP, Pg, androgen | |||||
XCL2, SCYC2 | XCL2, SCM1b | XCR1 | human | 1q23 | |||||||
CX3CL |
CX3CL1, SCYD1 | Fractalkine, Neurotactin (NTN) | CX3CR1 | human, mouse, rat | 16q13 | NF-kB, NRF2, PDX1, IL1, IFNg, TNFa, SCF, FSH, St, flagellin, EP4, IKKs, androgen | |||||
CCR (7TM) | CCR1 | CKR1, HM145, CMKBR1 | CCL3, 5, 7, 14, 15 ,16 ,23 | human, mouse | 3p21 | L | NF-kB, ARNT2, TNFa, RANKL, IFNa/b, IFNg, IL-2, IL5, IL6, IL8, PMA, IL15, LPS, b-glucan, Lm, CD3/28, RANTES, IL10, D3, ErbB4 | APCs |
|||
(G-coupled) | CCR2 | CKR2, CMKBR2 | CCL2(MCP1), 12,13, |
|
human, mouse | 3p21 | L | IL2,
IL15,
IFNa,
RANKL,
Lm,
Tc, NF-kB,
PMA,GCSF,
SCF,
estrogen,
D3 |
APCs |
||
CCR3 | CKR3, CMKBR3 | CCL5(RANTES), 6, 8, 11, 13, 15, 24, 26 | human, mouse | 3p21.3 | 1 | IFNg, IL2, IL3, IL4, IL25, estrogen | eosinophil |
||||
CCR4 | CKR4, CMKBR4 | CCL17, 22(Tarc, MDC) | human, mouse | 3p24 | L | BCR,
IL18,
G-CSF |
|||||
CCR5 | CCCKR5, CKR5, CD195 | CCL3, 4, 5 (MCP2, MIP1a, MIP1b) |
|
human,mouse | 3p21 | L | NRF2,
TNFa,
IL6,
IL12,
TCR,
PMA,
BCR,
Lyn,
IFNg,
M-CSF,
Tc, EV71,
IL10,
D3,
Rac2,
rapamycin |
APCs/T, HIV-1 coreceptor | |||
CCR6 | CKRL3/GPR29/GPRCY4/STRL22/CMKBR6 | CCL20(MIP3a,) | human, mouse | 6q27 | 1 | AIRE, IL10, IL4, IFNg, LPS, MDP, hypoxia/CD3 | B, Sd |
||||
CCR7 | EBI1, CMKBR7, CD197 | CCL21 | inhibit |
human, mouse | 17q12-q21.2 | L | NF-kB,
IL18,
Notch,
LPS,
Bm,
Ld,
Lm,
Mt,
Tg,
VLP,
PMA,
DAP12,
TREM2, estrogen,
D3 |
B/T |
|||
CCR8 | CKRL1/CMKBR8/CMKBRL2 | CCL22 (Tarc, MIP1b) |
human, mouse | 3p22 | L | ||||||
CCR9 | GPR-9-6, CCBP2 |
CCL25 |
|
human, mouse | 3p21.3 | L | TNFa |
TECK | |||
CCRL1 | CCRL1, PPR1 | human,
mouse |
3q22 | ||||||||
CCRL2 | CCRL2, HCR, CKRX, CRAM-A | human,
mouse |
3p21 | G-CSF, D3 | CD71+ |
||||||
CXCR (7TM) | CXCR1 | IL8R1, IL8Ra | CXCL6, 8 | human | 2q35 | NF-AT, NF-kB, PU.1, IL2, IL15, Subst.P, D3, IFNa | neutrophil |
||||
CXCR2 | IL8R2, IL8Rb | CXCL1,2,3,5,6,7,8 | human, mouse | 2q35 | L | Fas, camptothecin | neutrophil |
||||
CXCR3 | GPR9, CD183 | CXCL9, 10, 11, | human,
mouse |
8p12-p11.2 | L | SCF,
ribavirin,
TCR |
mDC |
||||
CXCR4 | Fusin,NPY3R, D2S201E, LESTR, HM89, LAP3, CD184 | CXCL12 (SDF1) |
|
human, mouse | 2q21 | L | NF-kB, USFs, c-Myc, YY1, CD40, , TCR/CD3, Tprim, BCR, PMA, LPS, Bm, Ld, Lm, Mt, Tg, Ma, IL2, IL4, IL7, IL13, IL15, VEGF, ALK1, BMP2, L-selectin, cAMP | B/T/NK/mDC |
|||
CXCR5 | BLR1 | CXCL13 | human, mouse | 11 | L | SCF, TNFa, IFNg | B, HIV coreceptor | ||||
CXCR6 | Bonzo, STRL33 | CXCL16 | human, mouse | 3p21 | 1 | HCV | |||||
CX3CR |
CX3CR1 |
V28, CCRL1, GPR13, CMKDR1,
GPRV28, CMKBRL1 |
CX3CL1 |
human,
mouse |
3p21 |
TNFa |
NK |
||||
XCR | XCR1 | GPR5/lymphotaxin receptor | XCL1, 2 | human,
mouse |
3p21.3 |
Tandem gene information:
17q12;
CCL2>CCL7>CCL11>CCL8>CCL13>CCL1>>>>CCL5>CCL16>CCL14>CCL23>CCL18>CCL3>CCL4>>CCL3L1>CCL4L>>CCL3L1>CCL4L
4q13.3;
IL8>CXCL6>PF4V1>CXCL1>PF4>CXCL5>CXCL3>>CXCL2
One-line review of
Chemokines by Cysterby(Science 1999), Melchers et al. (Cell 1999), Rossi & Zlotnik (Annu. Rev. Immunol. 2000)
Inducible Proteins for
Immunity
response | name | species | locus | KO | apoptosis | domain structure | 3D | binding partners | gene regulators | memo | |
viral | TPR |
IFI56, IFIT1, G10P1, RNM561, GARG-39 |
human | 10q23.3 | TPRs | IFNa,
IFNb,
IFNg(-),
BRCA1,IRF3,
PLZF,
BLP,
HCV,
TNFa,
TRAIL,
Fas,
FSH,
LPS,
LTA,
B-DNA,
Bm,
Hp, Ld,
Lm,
Mt,
Tg,
dsRNA,
VLP,
(p38),
ER,
ribavirin,
SOCS1 |
|||||
IFI54, IFIT2, G10P2, GARG-16 |
human | 10q23.3 | TPRs | AIRE,
IFNa,
EP4,
LPS,
LTA,
B-DNA,
Ct,
Bm,
Ld,
Lm,Mt,
Tg,
VLP,
IRF3,
(p38),
SOCS1 |
|||||||
IFIT3, IRG2, IFI60, IFIT4, ISG60, RIG-G, CIG-49, GARG-49 | human | 10q24 |
TPRs | Hp, VLP,
B-DNA,
SOCS1 |
|||||||
RIG-G, IFI60, IFIT4 | human | 10q24 | TPRs | LPS, Lm, Mt, Tc, Tg, IFNa, IFNb, TNFa, IRF3, (p38), glucose, HCV | |||||||
IFIT5, RI58 |
human |
10q23.3 |
IFNa,
LPS |
||||||||
OIAS | 2',5'-oligoadenylate synthetase, OIAS, OAS1 | human, mouse | 12q24.2 |
|
OAS | 1 | PLZF, TNFa, IFNa, IFNb, IFNg(-), LPS, Sm, HCV, tributyltin | 2-5As actiavates RNase L | |||
OAS2 | human | 12q24.2 | IFNa/b,
TNFa,
LPS,
Mt,
Tg,
HHV8,
IL12,
TGFb,
SOCS1 |
||||||||
OAS3, p100 | human | 12q24.2 | IFN, TNFa | ||||||||
TRIP14, OASL | human | 12q24.2 | OAS/Ub x2 | IFNa, TNFa, Bm,Ld, Lm, Mt, Tg, DV | |||||||
Exonuc. | ISG20, HEM45 | human | 15q26 | Exonuclease | IFNa,
IFNb,
IL13,
LPS,
LTA,
Bm,
Ld,
Lm,
Mt,
Tg,
estrogen,
TRIF,
SOCS1 |
||||||
ABC | RING4, TAP1 | human | 6p21.3 | L | ABC transporter | CIITA, IFNa, b, g, dsDNA,HCV, dsRNA, Hp, Hf, UVB | |||||
TM | IFI17, IFI9-27, IFITM1 | human, bovine | 11p15.5 | TMs | IFNa, b,g, BRCA1, TNFa, TRAIL, LPS, Ct, Bm,Lm, Mt, Tg, Bcl6, DAC/TSA, PMA, IL15, EBV, ribavirin, | anti-viral | |||||
IFITM2, IFI1-8D | human | 11p15.5 | TMs | IFNs,
Ets1 |
|||||||
IFITM3, IFI1-8U | human, mouse(fragilis), rat, bovine, | 11p15.5 | IFNa, LPS, Lm, Mt, Tg, TRIF | ||||||||
FAM14 | IFI6-16 | human | 1p35 | singal/TM | IFNa,
IFNb,
IFNg(-), HCV,
TNFa,TRAIL,
Fas,
N-Myc,ribavirin,
Ets1 |
||||||
IFI27, ISG12 | human | 14q32 | EWS/FLI-1, IFNa/b, VEGF, MVA | ||||||||
FAM14A | human | 14q32.2 | |||||||||
FAM14B | human | 14q32.2 | |||||||||
INDO | INDO, indole 2,3-dioxygenase | human | 8p12-p11 | enhance /inhibit | IL1,
IL12,
IL18,
TNFa,
IFNa,b,
IFNg,
LPS,
MDP,
ssRNA,
Bm,
Ld,Mt,
Tg,
VLP;
NO |
Trp to L-kynurenine |
|||||
Mx |
MxA, IFI78, MX1 | human, mouse, rat, pig, sheep, bovine, dog, chicken, duck, trout, zebrafish, fugu | 21q22.3 |
|
Dynamin/GED | m | IFNa, IFNb, IFNk, IFNg(-), IL2, BRCA1, LPS, LTA, Mt, Lm, dsRNA, B-DNA, HCV, DV, HHV8, (p38), ribavirin, TRIF | ||||
MxB | human, mouse, bovine, salmon | 21q22.3 | Dynamin/GED | IFNa, IFNb, IFNg(-), HCV, TRAIL, LPS, LTA, hsp65, Ld, Lm, Mt, Tg, TRIF | |||||||
IFI20x |
IFI16, p202, p204 (mouse) | human | 1q22 | SLE |
|
Pyrin/HINx2 | Rb, BRCA1, 53BP1, CBFA1, NF-kB, p202 | IFNa,b,g,
HCV,
TRAIL,
Fas,
IL5,
IL6,
IL12,
LPS,
B-DNA,
hsp65,
Tc, VLP,
BMPs,
HOXD3,
DEX,
p53,
BMP2,
TRIF,
SOCS1 |
systemic lupus | ||
MNDA | human | 1q22 | Pyrin/HINx2 | ||||||||
AIM2 | human | 1q22 |
|
Pyrin/HINx2 | IFNa/b | ||||||
secret | IFI30, IP-30, GILT | human | 19p13.1 | signal | IFNa,b,g, TNFa, EBV, AmB, Wnt3a | ||||||
PPM | IFI35, IFP35 | human | 17q21 | PPM | PLZF, IFNa,b,g, FSH, LPS, IL15, DEX | ||||||
SP110, IFI41, IFI75 | human | 2q37.1 | SAND | IFNa, b, IFNg | |||||||
GBP | GBP1 | human | GBP | IFNa, TNFa, dsRNA, B-DNA, LPS,MDP | |||||||
GBP2 | human | 1pter-p13.2 | GBP | IFNa,b,IFNg,
SOCS1 |
|||||||
TLCd | IFI44, p44, MTAP44 | human | 1p31.1 | TLCd | IFNa, b, IRF3, LPS, B-DNA, HCV | ||||||
C1orf29, GS3686 | human | 1p31.1 | IFNa/b, CIITA | ||||||||
TTF | TTF2 | human | 1p22 | DEXD/helicase | IFNa | transcriptional termination | |||||
crystallin | AIM1 | human | 6q21 | crystallinx6/ricin | ALK1, MITF, PLZF, E2F, GR, FSH, HHV8 | ||||||
Elp3 | CIG5 | human | 2p25.2 | Elp3 | IFNa, IFNb | ||||||
HD | SAMHD1, DCIP | human | 20pter-q12 | SAM/HD | IFNa/b, IFNg | ||||||
hORC2L | human | 2q33 | Pa, | ||||||||
Tristetraproline(TTP)/ZFP36 | human | 19q13.1 | 1 | EZF | Pa, St, mitogens, Sp1, CD3/28,FVIIa | destabilize TNFa mRNA | |||||
BRF1, ERF1, cMG1, ERF-1, Berg36,
TIS11B, RNF162B, ZFP36L1 |
human |
14q22-q24 |
1 |
inhibit? |
Tis11b_C/CCCHx2 |
IL-4,
Ca2+ |
|||||
PBEF | human, mouse, rat, | 7q22.1-7q31.33 | TNFa, PMA, BAFF, LPS, Bm, Ld, Lm, Mt, Tg, MDP, NO, | |
|||||||
NOS |
iNOS/NOS2/NOS2A | human, mouse, rat, guinea pig, dog, horse, carp | 17q11.2-q12 | L | enhance/inhibit | L | NF-kB, NRF, IRF1, C/EBPbeta, ATF2,Oct-1, Brn-3, RXR, PPARg, Elk3, STAT1, KLF6, p300, IL1b, IL13, IL15, IFNg, IFNb, somatostatin, Subst.P, LPS, MDP, sBLP, flagellin, St, Sd,HBx, O stress, shear stress, heat shock, hypoxia, PMA, progesterone, estradiol, DEX, D3, melatonin, NO,IL-4, Galpha13,PKCe, RON, Jak2, PI3K, p38, TGFb, IL10 | ||||
NOS II/NOS2B | human | 17p13.1-q25 | |||||||||
eNOS/NOS3 | human, mouse, guinea pig, bovine, pig, | 7q36 | L | Sp1, GATA-2, IL10, TNFa, PI3Kg, Jak2, MEK1, ERK1,2 | |||||||
nNOS, NOS1 | human, mouse, rat, rabbit, dog, fugu, zebrafish | 12q24.2-q24.31 | L | 1 | CREB, Oct-2, AgII | ||||||
ROS |
SOD2 |
human |
TNFa | ||||||||
HB-EGF | HB-EGF/diphtheria toxin receptor(DTR)/DTS | human,mouse, rat | 5q23 | L | inhibit/induce | signal/EGF-TM | 1 | AP1, v-Jun, p53,RARalpha, Cp, Hp, TNFa, IL1, PMA,GM-CSF, VEGF, gastrin, PAF, AGII, Thrombin, H2O2, stretch, shear stress, UVB, lysophospholipid, estradiol, progesterone, B-Raf, Raf-1, Ras, | mitogen binding to EGFR, inhibit NF-kB | ||
HGF | HGF, hepatopoietin A , scatter factor | human | 7q21.1 | L |
|
PAN/kringlex4/trypsin | c-Met(HGFR) | LPS, MDP, Ma, St, IL1, TNFa, IFNg, AP2, C/EBPs, Sp1, Sp3, USF, Stat3, DEX, ER, TGFb1,c-Src, | liver | ||
D2S448 | D2S448 | human | LRRs/IGx4/perioxidase/VWC | Ct | |||||||
G0s2 | G0s2 | human | 1q32.2-q41 | secreted | LPS, MDP, LTA | ||||||
MIF |
MIF | human, mouse | 22q11.2 | L |
|
MIF | 1 | LPS, polyIgA, CD3/28/TCR, VLP, thrombin, FXa, hypoxia, glucocorticoid, insulin, hypoxia, glucose, UV-B, VitE, estrogen | |||
D-dopachrome tautomerase, DDT | human, mouse, rat | 22q11.2 | MIF | ||||||||
MARCKS |
MacMARCKS |
human |
MARCKS |
Ca, CaM, PKCs |
LPS, |
||||||
GCH1 | GCH1, GTP cyclohydrolase 1 | human | 14q22.1-q22.2 | LPS,MDP | |||||||
LITAF | PIG7, LITAF | human | 16p13.3-p12 | LITAF | A-Myb,B-Myb, p53, LPS, APC, cantharidin, calcineurin | activate
NF-kB |
|||||
pentraxin |
PTX3 | human | 3q25 | 1 |
|
PTX | bacteria | NF-kB, E2F, EWS/FLI-1, IL1b, TNFa, CD43, IFNg, LPS, MDP, LTA | anti-bacterial/fungal | ||
SAP, APCS | human | 1q21-q23 | 1 | ||||||||
CRP | human | 1q21-q23 | PTX | ||||||||
neuronal pentraxin I, NPTX1 | human | 17q25.1-q25.2 | PTX | taipoxin | KCl | ||||||
neuronal pentraxin receptor, NPTXR | human | 22q13.1 | PTX | ||||||||
neuronal pentraxin I, NPTX1 | human | 9q31-q32 | Sushix3/HYRx2/Sushi/TNFR/EGFx6 | ||||||||
ADPrc |
CD38 |
human |
4p15 |
1 |
LPS,
hsp65,
TIMP1 |
||||||
GTPase | IGTP |
mouse | IFNa/b, IFNg, B-DNA,
Lm, LTA,
SOCS1 |
||||||||
GTPI |
mouse |
IFNa/b, IFNg, Lm, LTA,
SOCS1 |
|||||||||
cAMP/cGMP cleavage | GCH1, GCH, DYT5, GTPCH1 |
human |
14q22.1-q22.2 |
hph1 |
LPS |
cGMP |
|||||
PDE4B |
human |
LPS,
Lm, IL10 |
cAMP |
||||||||
CD87 |
CD87, UPAR, URKR |
human |
19q13 |
IFNa | |||||||
IFRD |
IFRD1, PC4, TIS7 |
human,
rat,
chicken,
frog,
zebrafish,
fugu,
fly,
Ce, At, Nc, An |
7q22-q31 | IFRD/IFRD-C |
IFNa | ||||||
SM15, IFNRP, SKMc15 |
human,
mouse,
rat, |
3p21.3 |
IFRD/IFRD-C | ||||||||
LSP1 |
LSP1 |
human |
11p15.5 |
caldesmon-C |
IFNa | ||||||
LENG4 |
LENG4, BB1 |
human |
19q13.4 |
TMx2/MBOAT /TM |
IFNa | ||||||
CRISP |
CRISP1 |
human |
6p21.1-p21.2 |
LPS |
thyroid |
||||||
FIZZ |
FIZZ3, resistin (RETN) |
human |
19p13.2 |
RETN |
neutrophils |
||||||
TGTP |
human |
B-DNA | |||||||||
TNF | SA | Serum amyloid A3 | human | TNFa, IKKs | |||||||
PAI2, PLANH2, Serpin B2, SERPINB2 | human | 18q21.3 | Serpin | TNFa,IKKs | |||||||
epiregulin | human | 4q13.3 | NF-kB, TNFa, IKKs | ||||||||
DUF758 |
TNFAIP8, GG2-1, SCC-S2, MDC-3.13 |
human |
inhibit |
DUF758 (without DED) |
TNFa,
ALA |
||||||
SEC6 | TNFAIP2, B94 | human, mouse, | 14q32 | SEC6 | NF-kB, TNFa, IL1, MDP, Ma, Bm, Ld, Lm, Mt, Tc, Tg | ||||||
XTP7 | human | 19q13.32 | SEC6 | HBx | |||||||
SEC6 | human, mouse, rat,zebrafish, fly, Ce, Sc | 5p15.33 | SEC6 | ||||||||
LOC283849 | human | 16q22.1 | SEC6 | ||||||||
AngII | Osteopontin | human, mouse, rat, chick, bovine, rabbit,J.quail, | 4q21-q25 | L |
|
Osteopontin/TM | alphavbeta(3) integrin | Oct1, Oct4, Sox2, Ets1, Hoxa-9, c-Myc, USF, AP-1, Egr1, p53, CBFA, TGFb, PTHrP, PDGF, HGF,AgII, LIF, IL6, M-CSF, IL1, PMA, FGF1, D3, ER, estrogen, progesterone,glucocorticoid, RA, ischemia,alendronate, glucose | |||
ErbB4 | ZCWPW1, FLJ10057 | human | 7q22.1 | cc/PWWP | ErbB4 | ||||||
Prostaglandin |
NOV |
NOV |
human |
8q24.1 |
IB/VWC/TSP1/CT |
EP4 |
|||||
IL13 |
SPRR |
SPRR1a |
human |
1q21-q22 |
Cornifin |
STAT6,
IL4,
IL13 |
tangue, tonsil, bradder |
||||
SPRR2A |
human |
1q21-q22 |
STAT6,
IL4,
IL13 |
bradder, guts |
|||||||
SPRR2B |
human |
1q21-q22 |
STAT6, IL4, IL13 |
Review of
Inohara N, Nunez G. " ML- a conserved domain involved in innate immunity and lipid metabolism " Trends Biochem Sci 2002 27, 219-221Other On-line papersAlloresponses by Lechler et al. (Nat Rev Immunol 2003), Parham & McQueen (Nat Rev Immunol 2003)
B7/CD28 by Salomon & Bluestone (Annu Rev Immunol 2001), Sharpe & Freeman (Nat Rev Immunol 2002)
B cell development by Hardy & Hayakawa (Annu Rev Immunol 2001)
B cell development & transcription by Busslinger (Annu Rev Immunol 2004)
B cell activation by Niiro & Clark (Nat Rev Immunol 2002)
Bare lymphocyte syndrome and the regulation of MHC expression. by Reith & Mach (Annu Rev Immunol 2001)
C-type lectin by Geijtenbeek et al. (Annu Rev Immunol 2004)
CD1 signaling by Brigl & Brenner (Annu Rev Immunol 2004), by Moody & Porcelli (Nat Rev Immunol 2003)
CD45 by Hermiston et al. (Annu Rev Immunol 2003)
Chemokines by Rot & Andrian (Annu Rev Immunol 2004), by Yoshie & Zlotnik (Immunity 2000)
Cytotoxic T lymphocytes by Barry & Bleackley (Nat Rev Immunol 2002)
Dendritic Cells by Banchereau et al. (Annu. Rev. Immunol. 2000), Shortman & Liu (Nat Rev Immunol 2002)
FcRs by Ravetch & Bolland (Annu Rev Immunol 2001), Kawakami & Galli (Nat Rev Immunol 2002), Takai (Nat Rev Immunol 2002)
Glucocorticoids in T Cell Development and Function by Ashwell (Annu Rev Immunol 2000)
IgA by Fagarasan & Honjo (Nat Rev Immunol 2003)
IgE switching by Geha et al. (Nat Rev Immunol 2003)
Innate Immunity by Hoffmann et al. (Science 1999)
Integrin by Pribila et al. (Annu Rev Immunol 2004)
KIR by Vilches & Parham. (Annu Rev Immunol 2002), Natarajan et al. (Annu Rev Immunol 2002)
L-selectin ligands by Rosen (Annu Rev Immunol 2004)
MHC Class Ib Molecule, Qa-1 by Jiang & Chess (Annu. Rev. Immunol. 2000)
MHC I function by Shastri et al. (Annu Rev Immunol)
MIF by Bell (Nat Rev Immunol 2002)
Macrophage activation by Gordon (Nat Rev Immunol 2003)
Mucosal T cells by Cheroutre (Annu Rev Immunol 2004)
NKs & DCs by Moretta (Nat Rev Immunol 2002)
Pattern recognition receptors (except Nods) bty Gordon (Cell 2002)
Positive and negative selection by Starr et al. (Annu Rev Immunol 2003)
T cell development by Spits (Nat Rev Immunol 2002), Germain (Nat Rev Immunol 2002)
T cell activation by von Boehmer & Fehling (Annu Rev Immunol 1997), Alberola-Ila et al. (Annu Rev Immunol 1997), Davis et al., (Annu Rev Immunol 1998), by Garcia et al., (Annu Rev Immunol 1999), Lanzavecchia & Sallusto (Nat Rev Immunol 2002)
TLRs by Takeda et al. (Annu Rev Immunol 2003) Kaisho & Akira (Biochim Biophys Acta 2002), Medzhitov (Nat Rev Immunol 2001)
Semaphorins by Kikutani & Kumanogoh (Nat Rev Immunol 2003)
Superantigen by Li et al. (Annu Rev Immunol 1999)
V(D)J recombination by Gellert (Annu Rev Biochem 2002)
Links
Link table in Nature Immunology
C. elegans extracellular matrix proteins
BD CD poster
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