Index Caspase CARD/DED/BIR Bcl-2  DD TNF/TNFR Kinases ILs Viral Lipid Engulf TF RING Toll Other Apop Other NFkB Alphabet

Proteins for Immunity

TLRs, related protein and non-lectin/Ig type pathgen recognizing proteins (Nod family is here)
 
Group Protein Species apoptosis
NF-kB act.
Binding Partner Structure KO gene locus regulators 3D memo
TLR

























Toll D.m.,D.p.,D.s., S.a., A.g.
induce
Tube, MyD88 LRR/TM/TIR 1 1
LPS, IL13, PMA TIR anti-fungal
TLR1 human, mouse, sea urchin
 
(BLP) LRR/TM/TIR L
4p14 IFNg, influenza A, Sendai, Hp TIR anti-bacterial
TLR2 human, Mf, mouse, bovine, chTLR2(chick), sea urchin
mediate
 induce
MD2, SP-A, zymosan, PGN, (L TA, BLP, LPS(?), porins, glycolipid, hsp70, hsp60), TRIF, MyD88, TRIAD3
LRR/TM/TIR L 1,2,3 4q32 NF-kB, STAT5, Sp1, Sp3, TLR4, LPS (-), PGN, LTA, Lm, TNFa, Fas, IFNa, IFNg, DEX, GCSF, TCR, PMA, Ec, Sa, influenza A, Sendai TIR, TIR(P681h) anti-bacterial
TLR3 human, mouse, bovine, (induce?)
 
(dsRNA, mRNA), TRIF, TRIAD3
LRR/TM/TIR 1
4q35 TRAIL, IFNa/b, IFNg, STAT1, LPS, LTA, dsRNA, B-DNA, Ec, Lm, SaLLO, PMA, IFNAR1, TRIF
anti-viral
TLR4 human, mouse, rat, bovine, dog, cat, chimpanzee, horsebaboon induce
induce
(LPS, sHA, hsp70, hsp60, heparan sulfate proteoglycan), CD14, MD2, MyD88, TLR5, BTK, JIP3, TRIAD3, NAD(P)H oxidase
LRR/TM/TIR L, d 1, m 9q32-q33 PU.1, AP1, MIF, TNFa, IFNa, IFNg, LPS, LTA, Lmhypoxia, Oxidant stress, PMA, estrogen, influenza A, Sendai, MIF
anti-Gram negative
TLR5 human, mouse, trout

flagellin, TLR4, TRIAD3
LRR/TM/TIR
1 1q41-q42 Ec, Hp, Lm, Sa, flagellin
anti-bacterial
TLR6 human, mouse

(BLP), BTK LRR/TM/TIR 1 1 4p15.1 PMA, Fas, LPS, LTA, Hp
anti-bacterial
TLR7 human, mouse

(ssRNA, imidazoquinolines, R-848, CpG) LRR/TM/TIR

Xp22.3 IFNaIFNg, LPS, LTA, Ec, Sa, influenza A, Sendai, PMA, MeDNA
anti-viral
TLR8 human, mouse

(R-848) LRR/TM/TIR

Xp22 LPS, PMA

TLR9, CpG1 human, mouse, pig, cat, dog, bovine,

(DNA,CpG), Ras, BTK, TRIAD3
LRR/TM/TIR L
3p21.3 CSF1, IgG, MeDNA
anti-bacterial
TLR10 human


LRR/TM/TIR
1 4p14 IgG

TLR11 mouse
induce
LRR/TM/TIR




uropathogenic bacteria
TLR12 mouse


LRR/TM/TIR





TLR13 mouse


LRR/TM/TIR





SIGIRR/TIR8 human, mouse
inhibit
LRR/TM/TIR L
11p15.5


18 wheeler D.m., Bm


LRR/TM/TIR 1 1 2R 56F7-56F8

anti-bacterial
Toll5/Tehao D.m., D.s.


LRR/TM/TIR
1



Toll7/Tollo/Tak1 D.m.


LRR/TM/TIR
1



Toll4/CG18241 D.m.


LRR/TM/TIR
1 2L


Toll6/CG7250 D.m.


LRR/TM/TIR
1 3L


CG5528 D.m.


LRR/TM/TIR
1 3L


Toll7/CG8595 D.m.


LRR/TM/TIR
1 2R


Toll3/DmMstProx D.m.


LRR/TM/TIR
1



Toll-related (under construction) grasshopper, mosquito (1, 2, 3, 6, Trex, Toll9),G.p.p.


TIR(partial)





Tol-1 C.e.


LRR/TM/TIR 1 1 I


RP105, CD180 LY64 (human), RP105(mouse)
supress

MD1 LRR/TM

5q12 AIRE, PMA, Ec, Hp, Sa

Synleurin human


LRR/TM

5q12


Adaptors








MyD88 human (S), mouse, frog, D.m.
induce
induce
IRAK,IRAK-2, IRAK-M, IL-1R, FADD, MAL DD/TIR L 1,2p21.3 3p21.3 IL-6, IRF1, STAT3, STAT5, IFNa/b, IFNg, IL6, IL15, IL21, TNFa, TRAIL, M-CSF, MDP, Ec, Hi, Mt, Sa, Ye, Yp, LPS, PMA, TCDD; TGFb

Ub
Tube D.m.
induce
Pelle, Toll, Cactus DD 1 1

Tube/Pelle DD
TIRAP, MAL human, mouse
induce
TLR4/MD2, MyD88, IRAK2, MAL /TIR L 1 11q24.2 LPS

TRIF, TICAM1, LPS2 human, mouse
induce
induce
TLR2, TLR3, IRF3, RIP, RIP3
/TIR/RHIM L
19p13.3 NF-kB, TNFa, IL1, IFNb, PAMPs, Hoxd10
for TLR3, 4, targets
TIRP, TRAM, TICAM2 human, mouse
induce
TLR4, TRIF, IL1R, IRAKs, TRAF6 TIR 1
5q23.1


SARM, TIR-1 (Ce), CG7915 (Dm)
human, mouse, rat, Ce, Dm, Ag,



ARMs/SAMx2/TIR


17q11



Tollip human, mouse, C.e.
(inhibit)
Tom1, IRAK, IL1R
C2//CUE
1 11p15.5 VLP

Ubiquitination
Pellino (Pli)
Dm, Ce

Pelle






Pellino 1(human, mouse)
mediate
IRAK, IRAK4, TRAF6


2p13.3 LPS, TRIF

Pellino 2(human, mouse)

IRAK, IRAK4, Bcl10



14q21 AP1

RNA helicase

MDA5, HELICARD
human, mouse,
( IRF3)
induce
(polyIC)
CARD/AAA/helicase
L

2p24.3-q24.3
IFNb, mezerein, B-DNA
casp, B, T, APCs
RIG-I, DDX58
human, mouse, bovine, pig, chicken, fugu,
induce (also IRF3)
induce

CARD/AAA/helicase L

9p12
IFNb



VISA, IPS1, MAVS, CARDIF
human, mouse, rat,

induce

CARD/TM L




NS3/4A
Kinase  IRAKs for IRAK family, see kinase    







ligand? SPAETZLE D.m.
 
Toll NGF 1 1
fungi inf.


HMGB1 human
induce
HMG 1




PGRP




PGRP-Ialpha, PGLYRP3
human, mouse, rat

PGN ami2x2

1q21

esophagus, fetal liver
PGRP-Ibeta, PGLYRP4
human, mouse


PGN ami2x2

1q21

esophagus
PGRP-S, tag7, PGLYRP, PGLYRP1
human, mouse, rat, bovine

PGN ami2 1
19q13.2-q13.3
TCR, Hf, Hp bone marrow
PGRP-L, PGLYRP2
human, mouse, pig

PGN ?/ami2

19p13.13

liver
PGRP D.m. (SA, SB1, SB2, SC1, SC2, SD)

PGN ami2




mediate Toll pathway
PGRP related phage lysozyme,[T7, T3, fYe03-12] bacterial[M.t., S.c., Cg, ]

PGN ami2



KAmt, w/RNApol, LB
Lysozyme
LYZ

lysozyme, LYZ (human, mouse M, P, rat)



lysozyme

12q14.3 MEF, GABP, RA, LPS, Sp, HCV, NRF2, TNF, TRAF2/TRAF5
APCs
LYZL6, LOC57151 (human)



lysozyme

17q11.2

testis
SPACA3, LYC3, LYZL3, SLLP1, ALLP17 (human)



lysozyme


17q11.2


testis
LYZL4, LYC4 (human)



lysozyme

3p22.1


testis
LYZL1, LYC2,  MGC33408 (human)



lysozyme

10p11.23

testis
LYZL2  (human)



lysozyme


10p11.23


testis
PNPK6288, LOC389852 (human)



lysozyme

Xp11.23

testis, skin
lactalbumin alpha, LALBA (human)



lysozyme

12q13

mammary gland
SLT
LYG1, LOC129530, SALW1939, Lysozyme G (human, mouse, chicken, Xl, zebrafish, Ec)



SLT



2q11.2

tongue
LYG2,  LYGH (human, mouse)



SLT

2q11.2


Other

























CD14 CD14 (human, mouse, rat, horse, bovine, rabbit)
mediate
mediate LPS, PGN LRR-GPI L, d 1 5q31.1 AP-1, AIRE, Sp1, MEF2D, PPARg, IFNg, PMA, TGFb1, IL13, LPS, Pg, Hf, C/EBPs, estrogen, PGE2, PMA, cAMP, ethanol 1
anti-bacterial, APCs
ML


MD2 (human, mouse, C. hamster, bovine)

TLR4, LPS, LTA, TLR2, MD2 ML 1 1,2 8q13.2 IFNg, SOCS3, PMA
APCs
MD1, Ly86 (human, mouse)

RP105, (LPS) ML 1 1,2 6p24.1 Myb, PMA, Tc
APCs, B
Npc2, HE2 (human)

cholesterol ML npc
14q24.3 AIRE 1 ubiquitous, highest in APCs
GM2A (human)

GM2 ML 1
5q31.3-q33.1
1 placenta, bronchia, preB
LBP

LBP (human, mouse, rat)

LPS, PGN
LBP L
20q11.23-q12 NRF2, RA, A2aR, Pg, Hp
liver
BPI (human, rabbit, bovine, Ce, At)


LBP

20q11.23-q12 Hp 1 neutrophil
BPIL1, RYSR, LPLUNC2 (human)


LBP

20q11.22

airway
BPIL3, LPLUNC6 (human)





20q11.22

alfactory epithelium
BPIL2 (human)


LBP

22q12.3

epidermis, digits
PLTP, LTP2 (human, mouse, rabbit, pig,)


LBP 1

20q12-q13.1 LXR, FXR, hypoxia, bile acid, fenofibrate, ErbB4
epidermis
LPLUNC1, C20orf114 (human)





20q11.1

airway
RYA3, LPLUNC3, dJ726C3.4、C20orf185 (human)



LBP

20q11.21



RY2G5, LPLUNC4, dJ726C3.5, C20orf186 (human)



LBP

20q11.21



CETP (human, rabbit)


LBP

16q21

lymph node, placenta, liver
Mindin

Spondin 2, M-spondin, Mindin, SPON2 (human, mouse)


FS/TSP1 1
4p16.3

NK
spondin 1, F-spondin, SPON1 (human, mouse)


FS/TSP1x6

11p15.2


CCF earthworms,  CG6895-PA(Dm)


beta 1,3-glucanase





BRICHOS
SP-C, PSP-C, SFTP2, SP5, SFTPC (human, mouse, rat)

CD14, LPS BRICHOS L
8p21 TTF1, GATA6, TAZ

lung
LECT1, CHM1, CHM-I, BRICD3, Chondromodulin (human, mouse, rabbit, chicken, zebrafish)


BRICHOS L
13q14-q21 Sp3, TGFb, FGF2, PTHRP

ITM2B, BRI, FBD, ABRI, BRI2, E25B, E3-16, BRICD2B (human, mouse, Ce, zebrafish)


BRICHOS dmt
13q14.3


ITM2A, E25A, BRICD2A (human, mouse)


BRICHOS

Xq13.3-Xq21.2


tenomodulin, TNMD (human, mouse, rat,


BRICHOS

Xq21.33-q23


BRI3, E25, Itm2c (human, mouse, chicken)


BRICHOS

2q37

APCs
GDDR (human)



BRICHOS

2p13.3



AMP18 (human)


BRICHOS

2p13.2


albumin albumin, ALB (human)

PG albumin x3


4q11-q13 C/EBPa, NF-IL6, HNF1, AP1, p53, HGF, HB-EGF, TNFa, DEX, H-Ras
Liver
alpha-fetoprotein, AFP (human)



albumin x3

4q11-q13
NF-kB, C/EBPs, FOXA, Nkx2.8, T3R, p53, ATBF1, DEX/GR, HNF1, HNF3, HNF4, AP1, RA/RAR/RXR, TGFb, HGF, 12-PGJ2, osmotic pressure, H-Ras, Raf, Rif, Butyrolactone I

fetal liver
apha-albumin, ALB2, ALBA, AFAMIN (human)



albumin x3

4q11-q13

liver
DBP (human)



albumin x2

4q11-q13


Serpin Serpin27A (Dm)





4q11-q13


mediate Toll pathway
C114 C114, PRKRIP1 (human, mouse, Dm, Ce, Nc)

dsRNA, PKR cc

7q22.1 IL11

Ig-related Proteins
 
Group Protein Species apoptosis
NF-kB act.
Binding Partner Structure KO gene locus regulators 3D memo
IgG sup. Ig Kappa (IGKC: ex: human)





2p12 NF-kB, ARNT2, TCR/CD3, PMA, TNFa, IL12, IL15, Hp, VDR



Lambda(IGLC1: ex: human)





22q11.2 TIMP1



heavy (human: const. ex: a1,a2, g1, g2, g3, g4, d, e,)



L
14q32.33 LPS, Hp, Sm, IL10/12, estrogen, IL5, Blimp1, Lyn, ARNT2, TIMP1


TREM1 TREM1(human, mouse) inhibit

DAP12 IG/TM

6p21.1 LPS, fungi
APCs


TREM2 (human)

DAP12
IG/TM 1

6p21.1




TLT1 (human)


IG/TM

6p21.1




TREML2, FLJ13693, C6orf76 (human)


IG/TM

6p21.32




RAGE, AGER  (human, mouse, rat, bovine)


IGx2/TM

6p21.3 IFNa


DAP12 DAP12, TYROBP (human, b, mouse, pig, cow)
inhibit

DAP12, CD94, KIR2DS2, TREM1, TREM2, ZAP70, Syk, NKG2D, NKp44 TM/ITAM L
19q13.1 TCR
NK, DC


DAP10 (human, mouse, pig)

NKG2D, PI3K TM L
19q13.1

B, T

TCR TCRa (ex:human) induce activate antigen, CD3, CD8, SH2s, Lck, TCRb IG/TM(VJC) L
14q11.2 LEF1, TCF1, CREB, HIV1TNFa, ALK1 1 T


TCRb (ex:human)

antigen, superantigens, CD3, TCRa IG/TM(VJC) 1
7q35 NF-kB,Hp, HCV, 1


TCRg (ex: human)

TCRd IG/TM(VJC)

7p15-p14 TCR, IL3, Mad1




TCRd (ex:human, mouse, rat, sheep, chicken, Xl)

TCRg IG/TM(VJC) 1
14q11.2 T3, IFNaNotch, PPARa



CD3g (human, mouse, rat, bovine, sheep) induce activate TCR IG/TM/ITAM(AP2) 1
11q23 SDF1, Mad1, Tc, HCV, camptothecin, TIMP1

T, NK


CD3e (human, bovine, sheep, dog, chicken)

TCR
1
11q23 Tc
T


CD3(human)

TCR IG/TM/ITAM 1
11q23 IFNa
T


CD3zeta, CD3Z (human, mouse,chick)

Syk, ZAP70, NKp46 TM/ITAMx3 1
1q22-q23 O2 stress, PMA, PPARa
NK, T

CD79 CD79A, mb1, Ig-alpha (human, mouse)

Ig/CD5/CD19/CD22/CD79b IG/TM/ITAM 1
19q13.2 Pax5, TIMP1

B


B29, CD79B, Ig-beta (human, rat)

Ig/CD5/CD19/CD22/CD79a IG/TM/ITAM

17q23 EBF, OBF1, GR, c-Myc, UVB, Lyn, TIMP1
B

CD8 CD8alpha, Lyt23 (human, mouse, rat, chick) induce/ inhibit activate MHC-I, Lck IG/TM L
2p12 ,ITM2A, CREB, HIV1, VLP, Ikaros L T, NK, for MHC-I


CD8beta, CD8B1 (human, mouse, rat, chick)


Ig/TM 1
2p12 CsA/FK506, IL15, LiCl, MVA
T

CD4 CD4, L3T4 (human,mouse, rat, chick)
induce
activate MHCII, TCR, LCK IGx3/TM L
12pter-p12 c-Myb, Elf1, Ets1,Ets2, MAZ, ZEB, HES1, TCR, PMA, HHV6, HHV7, HBx
APCs, for MHC-II

IgE Fc R, FceRI  IgE Fc R a,  FCER1A (human, mouse, rat)


IGx2/TM

1q23 STAT6, IL4, GATA1, Elf1, USFs, GCSF, BMP2 1 APCs


IgE Fc R g, FCER1G(human, mouse, rat)


TM/ITAM 1
1q23 TCR, Tc
APCs, NK

IgG Fc gamma R IgG Fc R 1, FCGR1A, IGFR1, CD64 (human)

high affinity for Fc g, periplakin IGx3/TM L
1q21.2-q21.3 IFNa, IFNg, IL1, LPS, Tc, D3, estrogen




IgG Fc RII, FCGR2A, IGFR2, CD32 (human)
inhibit
induce low affinity for Fc g IGx2/TM L
1q21-q23 LPS, IL8, IL10, SCF, DEX, hypoxemia
APCs


IgG Fc RIII, FCGR3A, IGFR3, CD16 (human a, b)

low affinity for Fc g IGx2/TM L
1q23 IFNg, IL2, IL3, IL8, HCV, ARNT2, IFNa, staurosporine

NK

Fc alpha R Fc alpha R, IgA Fc R, CD89, FcaR (human)


IGx2

19q13.2-q13.4 C/EBPa, Fas, Elf-1, camptothecin
APCs, Eo

CD7 CD7 (human, mouse)
mediate

CD3, CD45, PI3K, IG/TM/YEDM 1
17q25.2-q25.3 Notch, Ca2+, cAMP, IL5

NK, T

CD19 CD19 (human, mouse, pig)
mediate/ inhibit
mediate CD2, CD9, , CD81, CD225, Lyn, c-Abl, PI3K IGx2/TM L
16p11.2 Pax5, Lyn(P), CD81
B cell, RP105

B7 CD80, CD28LG1, B7-1 (human, mouse, rat)
prevent

CD28, CTLA4 IGx2/TM L
3q21 NF-kB, Bcl6, HLX, TCR/CD3, IL1, IL4, IL10, jagged-1, GM-CSF, TNFa, Fas, IFNb, IFNg, Hp, Yp, dsDNA, HIV Vpr, MVA, S-27609, LeIF, triptolide L


CD86, CD28LG2, B7-2 (human, mouse, rat)
prevent

CD28, CTLA4, MIR IG/TM L
3q21 NF-kB, ARNT2, BCR, IFNb,IFNg, TNFa/IFNg, CD40L, C4BP, LPS, MDP, S-27609, Hp, Lm, Tc, UDP-Glc, IL-3, IL10, IL18, GM-CSF, jagged-1, Jnk, p38, DEX, D3, PGE2, triptolide, estrogen, camptothecin
APCs


GL50, B7H2, B7RP1, ICOSL, LICOS(human, mouse)

ICOS IGx2/TM L
21q22.3 A2aR 1


B7H1, PD-1 ligand, PD-L1 (human, mouse)

PD-1 IGx2/TM 1

9p24 TNFa, IFNg, LPS, Hp, Sm, STAT1, TLR4,dsRNA, B-DNA




PDL2, B7-DC (human, mouse)





9p24.2 IL4, IFNg, LPS, Ag, Sm, STAT6,



B7H3(human, mouse), 4Ig-B7-H3 (human)


(IGx4+)IGx2/TM L
15q23-q24 PMA/Io, Inf.cyt.
IFNg


B7-H4, B7S1, B7x (human, mouse, rat)
(-)

BTLA IGx2/GPI

1p11.1



CD28 CD28, Tp44(human, mouse, rat,chick)
inhibit/ mediate
activate B7 family IG/TM L
2q33-q34 TNFa, TCR, Mt, MVA, Subst.P
T,  targets, IL2, CD30, AP-1 ,NF-ATp


CTLA4, CD152(human, mouse, rat)
mediate/ inhibit
supress
IG/TM L
2q33 Tprim., OX40, AIRE L T


ICOS/AILIM(human) prevent

IG/TM L
2q33 TNFa, LPS, IL4, IL12, IL23




PD-1, PDCD1 (human, mouse) involved?
PDL1, SHP2 IG/TM/ITIM L
2q37.3 Pax5, Egr1, Nur77



BTLA (human)

B7H4, SHP1, SHP2 IG/TM/ITIM

3q13.2

B

CD1 CD1a (human, pig, horse)

glycolipid, B2M IG/TM

1q22-q23 GM-CSF, Hp, MVA
Thy


CD1b (human, rabbit, sheep b1, b2, b3, guinea pig b1, b2, b3, b4, horse)

glycolipid, B2M IG/TM

1q22-q23 VEGF, IL13
L Thy



CD1c (human, guinea pig c1, c2, c3)

glycolipid, , B2M IG/TM

1q22-q23 IL13
Thy, APCs, B


CD1d (human, mouse d1, d2, rat d1, d2, sheep)

glycolipid, B2M, MHCII, gp180 IG/TM L
1q22-q23 Sp1, IL13, LPS, hsp65, androgen, D3

APCs


CD1e (human, monkey, rabbit, guinea pig)

glycolipid IG/TM

1q22-q23

Thy

semaphorin semaphorin B, SEMB, SEMAB, SEMA4A (human)





1q22
Ma



semaphorin D, collapsin 1, SEMA3A (human)
induce



1
7p12.1 FKHR



SEMA3B, SemA, SEMA5, SEMAA, LUCA1 (human)
induce





3p21.3





SEMA3C (human)





7q21-q31 TNFa




SEMA3D (human)





7q21.11




SEMA3E (human)





7q21.11




semaphorin J, SEMA4D , CD100 (human, mouse)

CD45, CD72 Sema/PSI/IG/TM 1
9q22-q31 CD40, LPS
B, T, NK, APCs


SEMA5A,semF, SEMAF (human)





5p15.2 VEGF, ARNT2



SIMA7A, JMH, CD108 (human, zebrafish)

CD232 Sema/PSI/IG/GPI

15q22.3-q23



plexin PLXNA1, PLXN1, NOV (human, mouse, Xl, Dm, Ce)

neuropilin-1, SEMA3A Sema/PSIx3/IGx4/TM(HAMP)/RasGAPx2

3q21-qter CIITA



PLXNA2 (human, mouse)


Sema/PSIx3/IGx4/TM(HAMP)

1q32.2 b-catenin



PLXNA3, SEX (human, mouse)


Sema/PSIx3/IGx4/TM

Xq28




PLXNA4 (human, mouse)


Sema/PSIx3/IGx4/TM

7q32.3




PLXNB1, PLXN5, SEP (human, mouse)


Sema/PSIx3/IGx3/cc

3p21.31




PLXNB2 (human, mouse)


Sema/PSIx3/IGx3/cc

22q13.33 estrogen



PLXNB3 (human, mouse)





Xq28




PLXNC1, VESPR (human, mouse)


PSIx2/TIG/IG/TM

12q23.3 FSH



PLXND1 (human)





3q21.3



IGSF IGSF2, V7, CD101 (human)


IGx7/TM

1p13

NF-ATc


IGSF3 (human)





1p13


Group Protein Species apoptosis
NF-kB act.
Binding Partner Structure KO gene locus regulators 3D memo

LIR ILT2, LIR1, CD85J, MIR7, LILRB1 (human)
inhibit?

HLA-A, B, HLA-G1, HLA-F (MHC-I), SHP1 IGx4/TM/ITIM

19q13.4
1 APCs, inhibit T act.


ILT4, LIR2, LILRB2, CD85D (human)

HLA-A,B,G1,F IGx4/TM/ITIM

19q13.4 Fas, IL13




LIR3, ILT5, LILRB3, CD85A, LILRB3 (human)

MHC-I IGx4/TM/ITIM

19q13.4




LIR4, ILT6, HM43, CD85E, LILRA3 (human)

FcRgamma IGx4

19q13.4 TIMP1
APCs


LIR5, ILT3, LILRB4, CD85K  (human)

MHC-I IGx2/TM/ITIM

19q13.4 St PhoP, Fas
APCs


LIR8, LILRB5, CD85C (human)

FcRgamma IGx4/TM/ITIM

19q13.4




LIR7, ILT1, CD85H, LILRA2 (human)

FcRgamma IGx4/ITAM

19q13.4 IFNa
APCs


ILT7, CD85G (human)

FcRgamma IGx4/ITAM

19q13.4

mDC


ILT8, CD85B (human)

FcRgamma IGx4/ITAM

19q13.4

APCs


LIR6, LILRA1, CD85E (human)

FcRgamma IGx4/ITAM

19q13.4




ILT11, LIR9, CD85F (human)

FcRgamma IGx2/ITAM

19q13.4

preDC


ILT10, CD85M (human)

FcRgamma IGx3

19q13.4




LAIR1 (human)
inhibit?

Ep-CAM, SHP1,SHP2,


19q13.4 G-CSF
APCs, B, T, NK

KIR (for NK) KIR2DL1/NKAT1(human)

HLA-C4,2,5,6 (MHC-I), B4 (/w S1), SHP1, SHP2 IGx2/TM/ITIMx2

19q13.4

NK


KIR2DL2/NKAT6(human)

HLA-C1,3,7,8 (MHC-I) IGx2/TM/ITIMx2

19q13.4
L NK


KIR2DL3, NKAT2, CD158b(human)

HLA-C1,3,7,8 (MHC-I) IGx2/TM/ITIMx2

19q13.4
1 NK


KIR2DL4, CD158d(human)

HLA-G, SHP2, SHP1(-) IGx2/TM/ITIM

19q13.4

NK, CD30


KIR2DL5 (human)


IGx2/TM/ITIM

19q13.4

NK


KIR3DL1, NKAT3, NKB1, CD158e (human)


IGx2/TM/ITIM

19q13.4

NK


KIR3DL2, NKAT4, CD158z (human)

HLA-A IGx2/TM/ITIM

19q13.4

NK


KIR3DL7 (human)





19q13.42

NK


KIR2DS1, CD158H (human)

HLA-C2,4,5,6, Syk, ZAP70 IGx2/ITAM

19q13.4

NK


KIR2DS2, NKAT5, CD158J (human)

HLA-B, C


19q13.4

NK


KIR2DS3, NKAT7  (human)





19q13.4

NK


KIR2DS4, NFAT8, CD158G (human)

HLA-C4


19q13.4

NK


KIR2DS5, NFAT9, CD158G (human)





19q13.4

NK


KIR2DS6, KIRX, CD158C (human)











KIR3DS1, NKAT4, CD158k (human)


IGx2/ITAM

19q13.4

NK



KIR3DL2 (human)





19q13.4

NK


IRTA1 (human)


IGx4/IM/ITIM

1q21




IRTA2, BXMAS1 (human)


IGx9/TM/ITIM

1q21

B


FCRH3 (human)


IGx4/IM/ITIM

1q21.2-q22



NCR LY95, NKp44, NCR2 (human)

HA, CD3zeta, DAP12, IG/TM

6p21.1 IL2



LY94, NKp46 (human)

HA, HN IGx2/TM

19q13.42 Mt, camptothecin,
NK


LY117, NKp30, 1C7 (human)

viral proteins IG

6p21.3

NK, (T, B)

Butyrophilin
Butyrophilin A1, BTN1A1 (human, mouse)


IG/TM/SPRY(ZF) 1

6p22-p21.3

 fat droplets in the milk

BTN2A1, BTF1 (human)


IGx3


6p22.1

T, NK, B

BTF1, BT2.1, BTN2A2 (human)






6p22.1

 

BTN2A3 (human)






6p22.1



BTF5, BT3.1, BTN3A1 (human)






6p22.1

T, NK

BTF4, BT3.2, BTN3A2 (human)






6p22.1

T, NK, (B)

Butyrophilin 3, BTN3A3 (human)






6p21.3 dsRNA
NK, T, (B)

Butyrophilin 2, BTNL2, BTL-II, HSBLMHC1 (human)





6p21.3 A2aR
sarcoidosis

BTNL3 , BTNLR (human)


IG/TM/PRY/SPRY

5q35.3



BTNL8 (human)






5q35.3


PBL

BTNL9 (human)






5q35.3

PBL

a1B a1B-glycoprotein, A1B, ABG, GAB, A1BG (human, rat)

CRISP3 IGx5

19cen-q13.2

Liver

beta-2-microglobulin B2M (human, mouse, rat)

CD1s
IG L
15q21-q22 NF-kB, GR, IRF1, TNFa, IL1, LPS, IFNg, IL1b/IFNg, MDV, HCV, IKKs


MHC-I HLA-A(human),B-L mediate mediate TCR, antigen, MIR MHCI/IG/TM L
6p21.3 AP1, NF-kB, Ets1, TNFa, TRAIL, RANKL, Fas, IL1, IFNs, CREB, PLZF, CBP, p300, PCAF, BRG1, CIITA, RA, IL1b/IFNg, LPS, hsp65, Hp, Hf, Sd, dsDNA, dsRNA, MDV, EV71, hypoxia, CSV-B3, HNF4a, IKKs, ALK1, TGFR1, calcineurin, T3, androgen, HHT L targets


FcRn, FCGRT (human)

B2M, IgG MHCI/IG/TM

19q13.3 IFNa, calcineurin 1 APCs, liver, passive immunity by milk

MHC-II HLA-DMa(human), b, DNa,DOa, DPa1, DPa2, DPb1, DPb2, DQa1, DQa2, DQb1-3, DRa, DRb1-9  mediate/inhibit mediate TCR, antigen, CD1d MHCII/IG/TM L
6p21.3 RFX5, RFX1, RFXAP, RFXANK, CIITA,NF-Y, CREB, Oct1, C/EBPa, AP1, AIRE, c-Myc, NF-IL6, STAT3, Stat4, ARNT2, TAF1, HDAC1, IFNg, IL1b/IFNg, GM-CSF, TNFa, Fas, CD40L, CD3/CD28, IL12, IL15, jagged-1, IL10, GM-CSF, insulin, IGF-II, LPS, hsp65, MDP, Hp, Hf, Sd, CpG, dsDNA, dsRNA, HCV, EBV, EV71, VLP, PTEN, Lyn, A2aR, TIMP1, triptolide, estrogen, androgen, RA, camptothecin L APCs, B,
targets

MIC MICA (human), mouse (RAEI, H60)

NKG2D MHCI/IG/TM

6p21.3 stress, IFNg, IL15
epithelial


MICB (human)

NKG2D MHCI/IG/TM

6p21.3 stress, IFNg, IL15
epithelial


CD74, HLA gamma, invariant chain (human),mouse, rat, horse, bovine,


CD74 1
5q32 androgen, HCV, Lyn, TIMP1

B, DC


CD92, CDw92, CTL1 (human)


CD74/DUF580

9q31.2


Tandem gene information:
mouse MHC; I(K), II{A(Ab, Aa),E(Eb, Ea)}, III{S(C4, Bf, C2, TNF)}, I{D(D,L), Qa(Q1, Q2...), T1a(T1, T2...)}, M(M1,..., NM7)
human HLA 6p21.3; II/D(DPB, DPA, DQB, DQB, DRB, DRA), III(C4B, C4A, Bf, C2, TNF), I (B, C, E, A, H, G, F)
19q13.42 loci of LIR/KIRs/NALPs; , LIRLRB3, LIRLRB5, LIRLRB2, LILRA3, (tweeny), LILRA2, LILRA1, LILRB1, ILT10, KIR2DS4, KIR2DL1, KIR2DL2, Fc alpha R, KIR2DL4, NK-p46, Pypaf3, Nalp2

Adhesion, Anchoring, Transcytosis, Anti-Adhesion Molecules, NKRs and Related Proteins
Group Protein apoptosis Species
locus
KO 3D binding partner structure TFs upstream regulators memo
CAM ALCAM, MEMD, CD166
human, mouse, rat, dog, chicken 3q13.1-q13.2

CD6 IGx5/TM
RANTES, LPS, IL3, M-CSF, GM-CSF, Blimp1

CD22, LEU14, BL-CAM, SIGLEC2
promote
human, mouse 19q13.1 L
sialylated staffs, CD45, AP50, SHIP1/Grb2/Shc IGx7/TM
IL1b, Fas, BCRLyn, LPS, GR, IKKg B vs B

MAG, SIGLEC4A
human, mouse
19q13.1

sialosides IGx4/TM
DEX, cAMP
brain

LU, BCAM
human 19q13.2


IGx5/TM



nephrin, Nphs1
human 19q13.1 1

IGx8/FN3/TM



CD33, SIGLEC3 induce
human 19q13.3-q13.4 1
sialosides

SDF1, Lm
APCs

SIGLEC5, CD33L2, OBBP2
human 19q13.3

sialosides IGx3/TM

bm

Nr-CAM, Bravo, NRCAM

human, mouse, rat, chicken 7q31.1-q31.2

contactin/F11, neurofascin,  RPTPb, axonin-1 IGx6/FN3x3/TM LEF-1 IL1a, b-catenin, Wnt brain

DDM36, NOPE

human 15q22.2







neogenin, NEO1
human 15q22.3-q23


IGx6/FN3x6/TM Pax6


PUNC
human 15q22.3-q23 1

IGx4/FN3x2/TM



MYBPC3
human 11p11.2


IGx6/FN3x2/IG/FN3/IG

heart

MYBPC2, fast
human 19q13.33


IGx5/FN3x2/IG/FN3/IG

heart, tongue


MYBPC1, slow
human 12q23.3


IGx5/FN3x2/IG/FN3/IG

skeletal muscle, tongue

contactin 1, CNTN1
human, mouse, rat, bovine, chicken,zebrafish 12q11-q12 1
tenascin, Fyn, RPTPbeta, CasprNF155, Na+ channel IGx6/FN3x4
St PhoP brain

contactin 2, CNTN2, TAX1, TAG1, axonin 1
human, rat, chicken, zebrafish 1q32.1 1

IGx6/FN3x4

brain

neurofascin, NFASC
human, rat, 1q32.1

contactin, Na+ channelNr-CAM, syntenin-1, ankyrin
IGx6/FN3x3/TM



IGSF9, Nrt1
human 1q22-q23


IGx4/FN3x2/TM



L1CAM, MIC5, MASA, SPG1, HSAS1, N-CAML1 CAML1, CD171

human, mouse, rat,
Xq28 1

IGx6/FN3x4/TM Pax6
brain

contactin 5, NB2, CNTN5
human, rat 11q21-q22.2







contactin 3, CNTN3, NIG1, PANG
human, mouse, rat 3p26







contactin 4, BIG2, CNTN4, Axcam
human, mouse, rat, 3p26-p25


IGx6/FN3x4



contactin 6, NB3, CNTN6
human, mouse, rat 3p26-p25


IGx6/FN3



CALL, L1CAM2, CHL1
mediate?
human 3p26.1


IGx6/FN3x4/TM

brain

ROBO1, roundabout 1
human 3p12


IGx5/FN3x2 TNFa


ROBO4
human 11q24.2


IGx2/FN3x2



BOC
human 3q13.2


IGx4/FN3x3/TM



JAM3
human, mouse 11q25







JAM2, VEJAM
human, mouse 21q21.2







DSCAM, CHD2-42, CHD2-52

human 21q22.2


IGx9/FN3x2/IG/FN2/TM



NCAM2
human 21q21.1


IGx5/FN3x2/TM
EV71

NCAM1, CD56
human, mouse, rat, bovine, chicken, Xl, zebrafish 11q23.1 L 1 prion IGx5/FN3x2/TM NF-kB, Phox2, HOXC6, Hoxc8, Alx4, LEF-1, PLZF, OTX2, Cux-2?, Barx1, p73 TGFb, BMP2, AMPA-R, D2R NK

CDON, CDO, ORCAM
human 11q23-q24


IGx5/FN3x3/TM



DSCAML1, KIAA1132
human 11q23


IGx9/FN3x4/IG/FNx2/TM



SDK2, sidekick 2
human 17q25.2


IGx3/FN3x5/TM



DCC, CRC18, CRCR1
induce
human 18q21.3 1

IGx4/FNx6/TM



VCAM1, CD106
inhibit
human, mouse, rat, pig 1p32-p31 1 L integrins, CD29 IGx6/TM NF-kB, Egr1, AP-1, IRF1, IRF2, GATAs, Sp1,PPARa, IL1, TNFa, LTa,dsRNA, IFNs,AngII, IL4, IL5, IL18, PKR, LDL, thrombin, C5a, Resistin, NO, RA, estrogens, glucocorticoids, UTP, LPS, BLP, Ct, Hp, Mt, Pc, ApoE, tax, osmolarity, P2Y2, p38, BMP2, IL10, ALA


ICAM1, CD54 inhibit/(-)/mediate human, mouse, rat, pig, sheep, bovine 19p13.3-p13.2 L L LFA-1, rhinoviruses, CD11, CD43, MIR IGx5/TM NF-kB, p53, c-Myc, EGR1, DLX-7, HOXD10, PDX1
IL1, IL5, IL6, IL18, TNFa, LTa, TRAIL, Fas, IFNaPMA, CD3/28, BCR, C4BP, histamine, C5a, ML-1, LPS, BLP, LTA, MDP, OX-CA, LeIF, hsp65, Bm, Cp, Ct, Ld, Lm, Ma, Mt, Pc, St, Tg, CMV(IE2, pp70), MV, HHV8, oxidative stress, irrrad, hypoxia, IFNg, RA, glucocorticoid, p38, PKCd, Src, Nef, IL1b/TNFa, heat shock, PGE2., IL10

ICAM3, CD50
mediate
human, bovine 19p13.3-p13.2

LFA-1, CD11, CD209 IGx4/TM
IFNa B, T, APCs

ICAM4
human 19p13.2-cen

LFA-1 IGx2/TM



ICAM5, TLCN, TLN
human, mouse 19p13.2


IGx7/TM



PECAM1, CD31
inhibit
human, mouse, bovine, pig, 17q23 L
CD38, Fyn, Lyn, Src, Yes, Hck, SHP1, SHP2, alphavbeta3 integrin, IGx5/TM/ITIM NF-kB, Egr1 TNFa, Fas, IFNa, IFNg, PMA, camptothecin APCs

ICAM2, CD102
inhibit
human, mouse 17q23-q25 1 1 LFA1, CD11b/CD18, CD209 IGx2/TM GATA2, TNFa, IL1, VEGF, Cp, Yp, ALK1

TCAM1
mouse, rat






testis

CMRF35
human 17q22-q24


IG/TM
Fas, camptothecin monocyte

CMRF35H9, IRC1
human 17q22-q24


IG/TM

NK, APCs

TREM4, LOC146894
human 17q21.31


IG/TM



NKIR
human 17q25.2


IG/TM



TACTILE
human 3q13.2


IGx3/TM

T, NK

LAMP, LSAMP
human 3q13.2-q21


IGx3/TM



IGSF10,  CMF608, FLJ25972
human 3q25.1


IGx7



MAdCAM1
human, mouse, rat 19p13.3
L CD29 IG NKX2.3 Hp, b-catenin


CEA, CEACAM5, CD66e
inhibit
human 19q13.2


IG x7 c-Myc, PPARg LPS,cisplatin

CD66a, BGP, CEACAM1
(-)/induce
human 19q13.2
1 Src, SHP1, SHP2, galectin-3 IGx3/TM/ITIM Hoxd10 RA, VEGF

CGM1, CD66d, CEACAM3
induce
human 19q13.2


IG/TM



CEAL, NCA, CD66c, CEACAM6
inhibit
human 19q13.2


IG x7
estrogen, As2O3 lung, bm

CEACAM7, CGM2
human 19q13.2


IGx2
RA

CD66b, CD67, CGM6, NLA95, CEACAM8
human 19q13.2

galectin-3 IGx3
hemin, PACAP

PSG3
human 19q13.2


IGx4

placenta

PSG8
human 19q13.2





placenta

PSG10
human 19q13.2





placenta

PSG1
human 19q13.2





placenta

PSG6
human 19q13.2





placenta

PSG7
human 19q13.2





placenta

PSG11
human 19q13.2





placenta

PSG2
human 19q13.2





placenta

PSG5
human 19q13.2



Sp1

placenta

PSG4
human 19q13.2





placenta

PSG9
human 19q13.2





placenta

TSLL2
human 19q13.32


IGx3/TM/4.1m



SIGLEC7
human 19q13.3
1
sialic aciddisialogangliosides, sialosides IGx3/TM
Fas, camptothecin NK, APCs

SIGLEC8, SAF2
human 19q13.33-q13.41

sialosides IGx3/TM



SIGLEC9
human 19q13.41

sialosides




SIGLEC10
human 19q13.3


IGx4/TM

B, NK

SIGLEC11
human 19q13.33


IGx4/TM

adrenal gland

SIGLECL1
human 19q13.4


IGx4/TM



OSCAR
human 19q13.42


IGx2/TM PU.1


PVR, PVS, CD155
mediate
human 19q13.2-q13.3 mt
PV, vitronectin, Tctex-1
NRF1, GLI1, GLI3 Shh, CMV


basigin, BSG, TCSF, EMMPRIN, CD147

human, mouse, rat, chicken, zebrafish
19p13.3 L
basigin, MCT1, MCT4
IGx2/TM Stat4b TSH
bm

SDFR1, gp65, gp55
human 15q22


IGx2/TM

brain

embigin, gp70IC
human, mouse, rat 5q11.2


IGx2/TM

bm

MGC71745

human
5q11.2



IGx2/TM

NK, B, T,  APCs

sialoadhesin, SN, CD169, SIGLEC1

human 20p13
L
sialic acid, sialosides IGx17/TM
IL-4, IFNb, IFNg, LPS
bm

NEPH1, KIRREL

human
1q21-q25



IGx4/TM



NEPH2, Kirre, SST4
human 11q24


IGx5/TM



MCAM, MUC18, CD146
human 11q23.3


IGx5/TM AP2 TNFa, IL1, hCG, PMA, cAMP

SYNCAM, TSLC1, BL2, ST17, IGSF4
human 11q23.2


IGx3/TM/4.1m



HVEC, PVRR1, PRR, nectin 1, PVRL1
human 11q23-q24 1
afadin, HSV IGx3/TM
Ma, Fas, camptothecin

nectin 2, Pvrl2, CD112, HVEB, PVR, PVS
human, mouse 19q13.2-q13.4 1

IGx3/TM



PVRL3, PPR3, PRR3, PVRR3, nectin-3,

human
3q13


afadin


placenta

CD47, IAP
mediate
human, mouse, rat, bovine, viruses 3q13.1-q13.2 L
SIRPs, alpha v beta 3 vitronectin, Rh, SHPS1 IG/TMx5
Yp, MVA, EV71, TNF, IL1, GM-CSF, NIP3, SDF1


CD200R, OX2R, MOX2R
human 3q13.2

CD200 IGx2/TM



CD200, OX2, MOX2
human 3q12-q13 1
CD200R IGx2/TM


CAM(IG) SNS, CG33141
Dm, Ag



IGx9/FN3/TM



CG8964
Dm







Tandem gene information:
19q13.2- 19q13.31; CEACAM1, CEACAM8, PSG3, PSG1, PSG6, PSG7, PSG11, PSG2, PSG5, PSG4, PSG9, PSG5, PSG4
 
Group Protein apoptosis Species
locus
KO 3D binding partner structure TFs upstream regulators memo
CD2 CD48
inhibit
human, mouse, rat 1q21.3-q22

heparan sulfate, CD2, 2B4, Lck, CD2BP1, Lyn, Fyn IG/TM PLZF Yp, EBV, G-CSF, IL13, TRAF2/TRAF5
B, T, NK, APCs

BY55, CD160
human 1q21.1

MHC-I IG/GDI
TCR
NK

IGSF4B, NECL1, TSLL1
human 1q21.2-q22


IGx2/TM/4.1m

brain

LFA3, CD58
inhibit
human 1p13
1 CD2 IG/TM p53 IL2, LPS, RA, DEX

AD026
human 1p12


IG



CD2
induce
human, hourse, 1p13.1 1
L CD48, CD2BP1, CIN85, CMS IGx2/TM
Ma, PTH, Notch T, NK

CD84
human 1q24

CD2 family members,
SHP2, SAP
IGx2/TM
D3 T

SLAM, CD150
human, mouse 1q22-q23

SAP IGx2/TM GR, STAT3 IL1, IL10, PMA,BCR, LPS, Hp Thy

Ly9, CD229
human, mouse 1q21.3-q22

SAP, CD48, AP-2 IGx2/TM AIRE
T, DC

2B4, CD244, Nmrk
human, mouse,rat 1q23.1 1

CD48 IGx2/TM
Rac2, TCR
NK

BLAME
human 1q22


IGx2/TM



SLAMF6, NTBA, KALI
human 1q22

SHP1, SHP2, SAP IGx2/TM/(TxYxxV/I)x2/ITIM



LNIR, PRR4, PVRL4
human 1q22-q23.2


IGx3/TM



SLAMF7, 19A24, CRACC, CD1
human 1q23-q24


IG/TM

DC, NK

SLAMF9, CD84-H1
human 1q22


IG/TM



F11R, JAM1, PAM-1
human, mouse, rat, bovine 1q21.2-q21.3
1 LFA1 IGx2/TM
IL5 epithelial

FGFRL1
human, mouse
4p16


IGx3/TM



IGSF4D, NECL3
human, mouse
3p12.2


IGx3/TM/4.1m

brain
CD83 CD83
human, mouse, rat 6p23 1
sialic acid
IG/TM NF-kB TNFa, CD40L, IFNg, CD38, IL4, PA, LPS, KF1B, Hp, Ld, Lm, Mt, Sm, Tg, Ye, LMP1, PMA, D3, Blimp1, TIMP1 B, APCs
TIM HAVCR, TIM1
human, mouse 5q33.2

HAV IG/Muc/TM



TIM2, Timd2
mouse


SEMA4A IG/Muc/TM
blastcysts


HAVCR2, TIM3
human, mouse 5q33.3 1

IG/Muc/TM

NK, Th1

TIM4, LOC91937
human, mouse 5q33.3


IG/Muc/TM


other pIgR
human, mouse, rat, rabbit, bovine 1q31-q41 1
IgA, CbpA, CaM, IGx5/TM IRF1, NF-kB, STAT6 IFNg, IL4, TNFa, androgen trtachea, IgA transport

FKSG87, Fcalpha/muR
human 1q31.3

IgA, IgM IG/?
IL1

Toso
inhibit
human, mouse, rat 1q31.3

FADD
IG/TM
IL2, TCR, Hp B, T, NK

kilon, MGC46680
human 1p31.1


IGx3



myopalladin, MYPN

human 10q22.1


IGx5



CNAIP, NFAM1
human, mouse 22q13.2


IG/TM/ITAM

kidney

MDGA1
human 6p21


IGx6/FN3/MAM/GPI



Thy-1, CD90
induce
human 11q23.3

Mac1
IG
Yp brain

neurotrimin, HNT
human 11q25


IGx3/GPI



OBCAM, OPCML
human 11q25


IGx3

(brain)

DKFZp566D234
human 4q32.3


KAZAL/EF/IGx2



palladin, CGI151
human 4q32.3

ezrin (FPPPP)/IGx5



myotilin, TTID
human 5q31


?/IGx2

skeltal muscle, tongue

FLJ20674
human 12q24.23


IGx3/TM



SIRPa1, SHPS1, MYD1, MFR, PTPNS1
(promote)
human 20p13

SHP1 UGx2/TM/ITIM



IGSF1, IGDC1
human Xq25


IGx5/TMx2/IGx6

pituitary

WFIKKNRP
human 17q21.33


WAP/KAZAL/IG/KUx2/C345C



perlecan,  HSPG2, PLC, SJA, SJS, SJS1

human, mouse 1p36.1-p35


SEA/LDLax4/IG/LamB/EGFx3/LamB/EGFx4/LamB/EGFx3/IGx21/LamG/EGFx2/LamG/EGFx2/LamG
TGFb, NO adipocyte, s.muscle, cardiac

hemicentin, fibulin 6, FIBL-6
human 1q25.3


WVA/IGx3/TSP1x6/G2F/EGFx8



hemicentin-2
human 9q34.2







titin
human 2q24.3


huge!

skeletal muscle
LRR/IG LRIG2, KIAA0806
human 1p13.1


LRRs/IGx3/TM



GAC1, LRRN2
human, mouse, rat, 1q32.1


LRRs/IG/TM

brain

LRRN3, NLRR3
human 7q31.1


LRRs/IG/TM
IL12, TGFb T, brain

FLJ31810
human, mouse, rat 9p21.1-p13.3



LRRs/IG/TM

brain

LERN1, UNQ201,, FLJ14594
human, mouse, rat, 15q24.1



LRRs/IG

(brain)

LRRN1
human, mouse, frog 3p26.2


LRR/IG/FN3/TM

T

LRRN3
human, mouse, rat 7q21.12


LRR/IG/FN3/TM

T, brain

LIG1, LRIG1
human 3p14


LRRs/IGx3/TM



FLJ90440
human 12q13.2


LRRs/IGx4/TM



PAL
human 10q23


LRRs/IG/FN3/TM



adlican
human Xp22.33


LRRs/IGx2/?/IGx10

adrenal
Group Protein apoptosis Species
locus
KO 3D binding partner structure TFs upstream regulators memo
SRCR CD6
inhibit
human, mouse, rat 11q13

CD166 SR x3/TM
PMA, Yp, D3 T

CD5, Leu1, Ly1
mediate
human, mouse, rat, sheep, chicken, 11q13 1
CD72 SR x3/TM/ITIM NFATs, E47, Ets1 TNFa, TCR, PMA, IgM, IFNa, Yp, PKCs, androgen T

DMBT1, gp340
human 10q25.3-q26.1

SFTPD SRx13/CUB/SR/CUB/ZP

trachea

see also CD160, M160





SRs


cadherin BR-cadherin, N-cadherin 2, CDH12
human, mouse 5p14-p13





B

K-cadherin, CDH6
human, mouse, rat, chicken, Xl 5p15.1-p14







cadherin 18, CDH18 (formerly CDH14)
human, rat 5p15.2-p15.1





brain

LI-cadherin, CDH17
human, mouse, rat 8q22.1


Cad.R x6/TM Cdx2
Sd, Sp pancreas

E-cadherin, cadherin-1, CDH1 inhibit/promote human, mouse, chicken, zebrafish 16q22.1 L L cytoskeletal proteins Cad.R. x5/Cad/TM/Cad-C  Snail, WT1, E12/E47, SIP1, Rb, c-Myc, AP-2, TGFb, DNA methylase, PS1, ET-1, LMP1, PMA

OB-cadherin, CDH11
human, mouse, chicken 16q22.1




PDGF s.muscle, cardiac, adipocyte

P-cadherin, cadherin-3, CDH3
human, bovine, pig 16q22.1 L
cytoskeletal proteins Cad.R. x5/ Cad/ TM/ Cad-C
ErbB2, ARNT2


VE-cadherin, CDH5, CD144
inhibit
human, mouse, pig 16q22.1 1
b-catenin, p120CAS Cad.R. x5/ Cad/ TM/ Cad-C Sp1, Sp3, Erg, Ets1, Egr1, RANKL lung, placenta

cadherin 8, CDH8
human, mouse, rat 16q21-q22.1







KSP-cadherin, CDH16
human 16q22.1





kidney

M-cadherin, cadherin-15, CDH15
human, mouse 16q24.3




MVA, Pg


T-cadherin, cadherin 13, CDH13
human, mouse, rat, chicken 16q24.2-q24.3


Cad.R x5 NF-kB TNFa, IKKs, irrad

T1-cadherin, CDH9
human 5p14







T2-cadherin, CDH10
human, chicken 5p14-p13





brain

BH-cadherin, PCDH7, BHPCDH
human, chicken 4p15

PP1a Cad.R x7/TM NF-kB TNFa, IL1, IKKs

R-cadherin, cadherin-4, CDH4
human, mouse, rat 20q13.3





brain

PB-cadherin, CDH22
human, mouse, rat 20q13.1




PTH brain

VR20, CDH26
human 20q13.2-q13.33





epithelium

N-cadherin, cadherin-2, CDH2
inhibit
human, mouse, bovine, chicken, zebrafish 18q11.2 L L cytoskeletal proteins Cad.R. x5/ Cad/ TM /Cad-C MyoD Rac2 s. muscle, cardiac

cadherin 7, CDH7
human, chicken 18q22-q23







cadherin 19, CDH19 (formerly CDH7)
human 18q22-q23





DRG


cadherin 20, CDH20
human, mouse 18q22-q23







desmocollin 1, DSC1
human, mouse 18q12.1 1


Cadx5/TM NF-IL6
skin, desmosome

desmocollin 2, DSC2
human, mouse 18q12.1





tongue, epithelium

desmocollin 3, DSC3
human, mouse, bovine 18q12.1




TNFa epithelium, tongue, skin

desmoglein 1, DSG1
human, bovine 18q12.1


Cadx5/CAD-C

skin, tongue

desmoglein 2, DSG2
human, mouse 18q12.1





epithelium

desmoglein 3, PVA, DSG3
human, mouse 18q12.1-q12.2 1




epithelium, tongue, tonsil

desmoglein 4, DSG4
human 18q12.1







PCDH10
human 4q28.3





brain

PCDH15
human 10q21.1 av






PCDH18
human 4

Disabled-1


adipocyte

FAT
human 4q34-q35


Cadx34/EGF/LamininG/EGFx4/TM

epithelium

FAT2, MEGF1
human, rat 5q32-q33





cerebellum

otocadherin, CDH23
human, mouse,rat 10q21-q22 mt






 
group name apoptosis species locus KO 3D binding partner structure TFs upstream regulators memo
protocadherin alpha 1, PCDHA1
human 5q31





brain

PCDHA2
human 5q31





brain

PCDHA3
human 5q31





brain


PCDHA4
human 5q31





brain

PCDHA5
human 5q31





brain

PCDHA6
human 5q31





brain

PCDHA7
human 5q31





brain

PCDHA8
human 5q31





brain

PCDHA9
human 5q31




IL1
brain

PCDHA10
human 5q31





brain

PCDHA11
human 5q31





brain

PCDHA12
human 5q31





brain

PCDHA13
human 5q31




TNFa
brain

PCDHB1
human 5q31







PCDHB2
human 5q31







PCDHB3
human, mouse 5q31







PCDHB4
human, mouse 5q31







PCDHB5
human, mouse 5q31







PCDHB6
human, mouse 5q31







PCDHB7
human, mouse 5q31







PCDHB8
human 5q31







PCDHB9
human 5q31







PCDHB10
human 5q31







PCDHB11
human 5q31







PCDHB12
human 5q31







PCDHB13
human, mouse 5q31







PCDHB14
human, mouse 5q31







PCDHB15
human, mouse 5q31







PCDHB16
human, mouse 5q31







Pcdhb22
mouse








protocadherin gamma A1, PCDHGA1
human, mouse 5q31





brain

PCDHGA3
human, mouse 5q31





brain


PCDHGA4
human 5q31





brain

PCDHGA5
human 5q31





brain

PCDHGA6
human 5q31





brain

PCDHGA7
human 5q31





brain

PCDHGA8
human, mouse 5q31





brain

PCDHGA9
human, mouse 5q31





brain

PCDHGA10
human 5q31





brain

PCDHGA11
human 5q31





brain

PCDHGA12
human 5q31





brain

protocadherin gamma B1, PCDHGB1
human, mouse 5q31





brain

PCDHGB2
human, mouse 5q31





brain

PCDHGB3
human 5q31





brain

PCDHGB4
human 5q31


Cadx5/TM

brain

PCDHGB5
human 5q31





brain

PCDHGB6
human 5q31





brain

PCDHGB7
human, mouse 5q31





brain

Pcdhgb8
mouse 5q31







protocadherin gamma C3, PCDHGC3
human 5q31





brain

PCDHGC4
human, mouse 5q31





brain

PCDHGC5
human 5q31





brain

PCDH12
human 5q31





brain

PCDH1
human 5q32-q33







PCDH19
human Xq13.3





brain

PCDH11X
human Xq21.3







PCDH11Y, protocadherin-PC
affect?
human Yp11.2







protocadherin 15, PCHD15
human, mouse 10q21-q22 US

Cadx11/TM



protocadherin  16, PCDH16 
human 11p15.4







PCDH8, PAPC
human 13q14.3-q21.1




Mesp2 brain, epithelium boundary

PCDH9
human 13q14.3-q21.1





brain

PCDH17
human 13q14.3




IL1
brain

PCDH20
human 13q21





brain

CDH24, FLJ25193
human 14q11.2


Cadx4



also see flamingo subfamily of 7TM









tandem gene information:
5p31; PCDHA1-13 (common C-terminas), PCDHB1, 2,3,4,5,....15, PCDHGA1-A12/B1-B7 (common C termimus)
 
group name apoptosis species locus KO 3D binding partner structure TFs upstream regulators memo
integrin alpha 1, CD49a, ITGA1
human, mouse, rat, 5q11.1 1

FG-GAP/VWA/FG-GAPx4
Sd, Ct

alpha 2, CD49b, ITGA2
inhibit
human, mouse, bovine 5q23-31


FG-GAP/VWA/FG-GAPx4/TM/Int_A Sp1, Osf PMA, PDGF, SCF, IFNa, Lm, PKCzeta, Erb-B2, v-Ras, hypoxia, HHV8

alpha 2b integrin, CD41,

human, mouse 17q21.32


FG-GAPx5/TM/Int_A C/EBP
bm

alpha 3, CD49c, ITGA3
inhibit
human, mouse 17q23.3

TM4SFs FG-GAPx5/TM
Ma, irrrad, RANKL epithelium

alpha 4 , CD49d, ITGA4
inhibit
human, mouse 2q31-q32 1
TM4SFs

IL-2RIF, IL6, LPS, Pg, TIMP1
B, T, NK, APCs

alpha 5 , CD49e, ITGA5
inhibit
human, mouse, Xl 12q11-q13 1
TM4SFs, ADAM17
Sp1, Sp3, Smad4, C/EBP, Ets LPS, OX-CA, CtTNFa, RANKL, IL10, TGFb1, IGFBP2, IGF1



alpha 6 , CD49f, ITGA6
human, mouse, chicken 2q31.1

TM4SFs
c-Myc CD3, insulin, IGF1, insulin, FSH, TGFb1, Tprim, RA, hypoxia, MA3Ks, IGFBP2, LPS, Sm
epithelium

alpha 7, ITGA7
human, mouse 12q13



Stat4 b-glucan, Ma, BMP2, BMPs, HIV Vpr heart, adipocyte

alpha 8, Itga8
human 10p12.32 1



cisplatin, phenytoin

alpha 9, ITGA9
human, mouse 3p21.3




estrogen

alpha 11, ITGA10
human 1q21







alpha 11, ITGA11
human 15q22.3-q23







alpha E integrin, CD103
human, mouse, rat E1, 17p13

E-cadherin, beta 7 integrin

TGFb, Ct, Pg, ALK1, ALK5, PMA, cisplatin, estrogen

alpha L, CD11a, LFA-1a, ITGAL
human, mouse 16p11.2 1



MDP, Cp, Ma, EV71, RANKL, IFNa
T, NK

alpha M, CD11b, MAC1A, MO1A, ITGAM, CR3A
mediate
human, mouse, rat 16p11.2 1


Sp3 SCF, TNFa, LTa, IL2, IL4, hemin, PACAP, Am80, MDP, Ma bm, NK,
induce NF-kB

alpha V integrin, CD51, ITGAV
mediate/ inhibit
human, mouse, chicken 2q31-q32

ADAM15, alphaV, ntin
GATA1 TNFa, PMA

alpha X integrin, CD11c, ITGAX
human, mouse, rat 16p11.2



Sp1, Sp3, AP1, Ets,Oct2, c-Myc, GABP, Pur alpha, PU.1 GM-CSF,TNFa,LTa, IL2, IL4, PMA, Hp, Ma, CSBG, SB, PKCzeta,,fibronectin, SDF1 NK, DC

alpha D, CD11d, ITGAD
human 16p13.1-p11



Sp1, Sp3


beta 1, CD29, ITGB1
inhibit
human, mouse, rat, bovine, Xl 10p11.2 L
VCAM1, MAdCAM1, TM4SFs, ADAM17 PSI/VWA/TM c-Myc, N-Myc, NF-kB, HOXD10, Pax6, SCF, TNFa, GM-CSF, PMA, LPS, MDP, Ma, HCV, hypoxia, cisplatin, TIMP1


beta2 , CD18
inhibit/ mediate
human, mouse, 21q22.3 L

PSI/VWA/TM PU.1, NRF2, GABPs TNFa, LTa, IL2, IL4, SCF, MDP, Hp, Ma, Mt, Tc, HCV, MVA
induce NF-kB

beta3 , CD61, GP3A, ITGB3
mediate/ inhibit
human, mouse, rat 17q21.32 1
ADAM15, alphaV, osteopontin
HOXA10, Stat6, ARNT2
b-glucan, D3, IL4
calpain

beta 4 , CD104, ITGB4
inhibit
human, rat 12q13.13

laminins, alpha 6 integrin
GABPs TGFb1, SCF, HIV Vpr, SDF1


beta 5, ITGB5
human, mouse, bovine 3q21.3

betaig-h3
Sp1, Sp3, PU.1 GM-CSF, PMA, TGFR1, RA, insulin, IGF-II


beta 6, ITGB6
human, mouse, bovine 2q24.2 L



CD3, hypoxia

beta 7 , ITGB7
human, mouse 12q13.13




IL-2RIF, TGFb1, UVB, cisplatin B, T, NK, DC

beta 8, ITGB8
human 7p21.3




Fas, LPS, Ma, cisplatin

Tenascin-C, TNC, cytotactin, HXB
human, mouse, pig, chicken 9q33 1

EGFx14/FN3x15/FBG
TNFa, D3, HPV16 epithelium, adipocyte
LINK CD44
inhibit
human, mouse, rat, bovine 11p13 L
hyaluronan, aggrecan, collagen, IpaB LINK/TM Egr1, AP1, HMG-I, TEL, EWS/FLI-1, Hoxd10 EGF, TNFa, RANKL, IL1b, IL2, IL5, IL10, M-CSF, GM-CSF, OPN, LPS, MDP, Ct, Ma, Ld, Lm, Mt, Tg, PMA, dsRNA,irrad, PKCs, Ca, BMP2, TIMP1, ROK, VDR, A2aR, estrogen, P2Y2

LYVE-1
human, mouse 11p15

hyaluronan LINK/CUB
Prox1, VEGF-C lung, placenta

TSG6, TNFAIP6
human, mouse 2q23.3 1 1 hyaluronan

IL1, TNFa, G-CSF, LPS, MDP, LTA, Bm, Ld, Lm, Mt, Tg, AmB neutrophil migration

stabilin 1, STAB1

human, mouse 3p21.31

hyaluronan EGFx6/FAS1x2/EGFx5/FAS1x2/EGFx6/FAS1x2/EGFx5/LINK/FAS1/TM

bm, monocyte

FELL,  stabilin-2
human, mouse 12q23.1

hyaluronan EGFx6/FAS1x2/EGFx5/FAS1x2/EGFx6/FAS1x2/EGFx5/LINK/FAS1/TM



aggrecan 1, AGC1
inhibit
human, mouse 15q26.1 m
CD44 IG/LINKx2/(SGXXSG)xn/CLECT scleraxis, SOX9; ADAMTS5



BEHAB, brevican, BCAN
human, mouse, Xl 1q31 1

hyaluronan IG/LINKx2/EGF/CLECT/CCP
brain


chondroitin sulfate proteoglycan 2, versican, CSPG2
human, mouse 5q14.3


IG/LINKx2/EGFx2/CLECT/CCP Rb, bm, monocyte, Wnt-3A, D3, irrad

neurocan, CSPG3
human, mouse 19p12 1
CD56, tenascin-C, Ng-CAM, ,  IG/LINKx2/EGFx2/CLECT/CCP
brain


BRAL1
human, mouse 1q21.2


IG/LINKx2
spinal cord, brain


CRTL1
human, mouse, chick 5q14.3




cardiac


 
group name apoptosis species locus KO 3D binding partner structure TFs upstream regulators memo
Tetraspanin (TM4) CD9
induce
human, mouse, rat, cat, bovine, pig, chicken, zebrafish, trout, salmon 12p13 L
CD63, CD81, CD82, PCG17, HLA-DR, -DM, DO, PKC Tetraspanin
St PhoP, PMA, VEGF, UVB, D3, TCR, calcineurin targets

IgE Fc R b, CD20, MS4A1 mediate/inhibit human, mouse 11q13


Tetraspanin
irrrad B

ROM1, ROSP1

human
11q13


Tetraspanin



TM4-B

human
19p13.2



Tetraspanin



CD37
human, mouse 19p13-q13.4 L
CD53, CD81, CD82, MHC-II, PKC Tetraspanin
D3, androgen, OX40, IL3, IL13
B

CD53
inhibit
human, mouse, rat 1p13

VLA4, HLA-DR, PKC, CD49d/CD29, Tetraspanin
GnRH, IL3, Tg, Hp, Sp, PMA, androgencamptothecin, cisplatin, staurosporine, paclitaxel, LiCl B, T, NK, APCs

CD63
(?)
human, mouse, rat, rabbit, bovine, Xl 12q12-q13

VLA3, 6, HLA-DR, CD9, CD49d, CD29, CD81, CD82, AP3 Tetraspanin c-Myc LPS, PACAP, IL5

LOC90139

human
11p11.2








CD82, kangai 1, KAI1, SAR2, ST6 
induce
human, mouse 11p11.2

CD4, CD63, HLA-DR, VLA 3,6, CD49d/CD29, PKC, HIV1 gp Tetraspanin p53, NF-kB irrrad, BMP2

CD81, TAPA1
regulate
human, mouse, rat, Ca, So, zebrafish 11p15.5

Leu13/CD19/CD21, HLA-DR, CD49d/CD29,CD4 Tetraspanin
HIV Vpr liver, lung

CD151, PETA-3
human, monkey, mouse, rat 11p15.5 1

a3b1, a4b1, a5b1, a6b1, a6b4, aIIbb3, integrins, PI4K, PKC Tetraspanin
Ret


PHEMX, TSSC6

human
11p15.5



Tetraspanin

T, NK

TSPAN-1, tetraspan 1, NET-1
human, mouse 1p34.1


Tetraspanin p73
epithelium

TSPAN-2, tetraspan 2, TM4SF
human, mouse, rat, 1p13.1


Tetraspanin
TGFb
bladder

NET-2, TM4SF12

human, mouse 7q31.31





thyroid

tetraspan 3, TM4SF8, TSPAN-3
human, mouse 15q24.1


Tetraspanin
TNFa, RA, B-DNA


TSPAN-5, tetraspan 5, NET-4, TM4SF9

human, mouse 4q23


Tetraspanin

CD71+

DC-TM4F2

human
10q23.1



Tetraspanin



CO-029, TM4SF3
human, mouse, rat 12q14.1-q21.1


Tetraspanin
HOX11

NET-5
human, mouse, rat 12p13.33


Tetraspanin



SAS
human, mouse, Xl, zebrafish 12q13.3


Tetraspanin
Ma

NET-6, TM4SF13

human, mouse, rat 7p21.3


Tetraspanin
IL12 DC

MGC50844

human
7q32.3



Tetraspanin

B, kidney

NET-7
human 10q22.1


Tetraspanin



EMP2
human, mouse, Xl 16p13.2


Tetraspanin

lung

UPK1A, uroplakin 1A, UPIA, UPKA

human
19q13.13



Tetraspanin



UPK1B, uroplakin 1B

human
3q13.3-q21



Tetraspanin

trachea

LOC116441, BC014339
human 3q24


Tetraspanin



ILTMP, TM4SF4
human, mouse 3q25

b1 Tetraspanin

liver

LOC116211, BC013113
human 3q29


Tetraspanin



L6H, TM4SF5
human, mouse, rat 17p13.3


Tetraspanin

liver

OCSP, oculospanin

human
17q25.3



Tetraspanin



CD231, TM4SF2, MXS1, A15
human, mouse Xq11.4


Tetraspanin
FSH brain

TM4SF6
human, mouse Xq22


Tetraspanin



tetraspanin 4,NAg2, TM4SF7
human, mouse 11p15.5


Tetraspanin



TM4SF1, M3S1, TAAL6
human, mouse 3q21-q25


Tetraspanin NF-IL6, EWS/FLI-1 TNFa, Ld, Lm, Mt

SB134, FBX23, MGC14859
human, mouse 5q35.3


Tetraspanin



RDS, RP7, AVMD, PRPH, AOFMD, PRPH2

human
6p21.2-p12.3



Tetraspanin


PMP22 (TM4) PERP, PIGPC1, KCP1 induce human, mouse, rat 6q24 1



p53 epithelium

BCMP1, TM4SF10
human, mouse, frog Xp11.4





brain, spinal cord, adipocyte

LIM2, MP19
human 19q13.4






podocalyxin
CD34
human, mouse, goat, pig, bovine, dog, cat 1q32

L-Selectin, CrkL podocalyxin/TM c-Myb, Ets2,NF-Y, Sp1, MZF1, NC-3A, TGFb1, TGFR1, VEGF, UVB, ALK1, TNFa
bm
podocalyxin 1, PCLP, Gp200, GCTM2, PODXL

human
7q32-q33
1

L-selectin, ezrin, NHERF2
podocalyxin/TM WT1, p53

kidney
endoglycan, PODLX2

human
15






brain
mucin mucin 1, MUC1
inhibit
human, mouse 1q21 L
CD169 simple repeats/SEA/TM c-Myc IFNg, TNFa, IL7, PMA, TACE, estrogen lung

mucin 2, MUC2
human, mouse 11p15.5 L


Smad3/4, Stat4, NF-kB, Sp1, Sp3, GATA5
TGFb, TNFa, IL1, IL9, EGF, PMA, RA, Hi, adenosine, VitA

MUC3A
human 7q22



GATA5 IL4, IL6, EGF, PMA


MUC3B
human 7q22







MUC4
human 3q29


VWD Smad2/7, PEA3, GATA5
ErbB2, TACE, smoke
trachea

mucin 5AC, MUC5AC
human 11p15

H. pylori,

CREB, Sp1
TNFa, IL1, IL4/(-), IL6, IL9/(-), IL13/(-)IL17, TGFbEGF, PAF, LPS, Pa, RSV, Rhinoviruschymase, smoke, DEX, PGE2, azithromycin; TACE
trachea

mucin 5B, MUC5B
human, mouse 11p15



c-Myc IL6, IL17 trachea

MUC6

human
11p15.5-p15.4


VWD/ZnF/VWD//TILx2/extensin/CT


TGFb


mucin 8, MUC8
human 12q24.3




TNFa, IL1

VWF
human, mouse 12p13.3 1




lung
sialophorin sialophorin, SPN, leukosialin, CD43
inhibit
human, mouse, rat 16p11.2 L
ICAM1, moesin, ezrin ?/TM
Pur alpha, estrogen, Ma, Tc targets
sialomucin CD164
human 6q21




AraC DC, placenta
MIC2 MIC2, E2, CD99
human Xpter-p22.32, Ypter-p11.2


?/TM
ribavirin
lysosomal/ plasma membrane shuttling, scavenger
CD68
human, mouse 17p13


Lamp/TM Elf1, PU.1, IRFs, AIRE GnRH, Ct, Sp, HCV, EV71, Blimp1


LAMP1
human










LAMP2
human
Xq24 1



calcineurin


LAMP, DCLAMP, TSC403, DC-LAMP, LAMP3
human
3q26.3-q27


LAMP/TM

LPS, TNFa, Fas, CD40L

Syndecan Syndecan 1, CD138
inhibit
human, mouse, rat, frog, Dm 2p24.1 1

Syndecan
WT1 RANKL, thrombin, FGF2, PDGF-BB, TGFb1, IL1b, RA, D3 epithelium, placenta, liver,
shadding by Pa

Syndecan 2, SDC2, SYND2, HSPG, HSPG1, fibroglycan
human 8q22-q23




TRRAP thyroid, liver, adipocyte

Syndecan  4, amphiglycan, ryudocan, SDC4
human 20q12 1


NF-kB TNFa, IL1, PTH, VEGF, A2aR, Ye

Syndecan 6   human





RANKL

PSGL1, CD162, SELPLG
human 12q24

P-selectin, E-selectin Syndecan/TM
G-CSF
CD24 CD24
induce
human, mouse, rat 6q21 L
CD24
AIRE Sp, Sm, EV71, aa stavation, estrogen, androgen, PMX2, La(NO3)3
thyroid, B, epithelium
ECM1
ECM1 (human)


1q21






activate NF-kB
LAB LAB, WBSCR5
human, mouse, rat, 7q11.23

Grb2, PLCg1, PLCg2


B, NK, monocyte, bm

 
group name apoptosis species locus KO 3D binding partner structure TFs upstream regulators memo
selectin L-selectin, LAM, LEU8, CD62L, SELL (inhibit) human, mouse 1q23-q25 L
carbohydrate ligands; GlyCAM-1, CD15su, CD34, PCLP, PSGL1, ELAM, nucleolin, CD162R CLECT/EGF/Sushi x2/TM STAT1, STAT3 IL2, IL3, OX40, Cp, Ct, Ma, tax, CsA/FK506, staurosporine
B, T, NK, APCs

E-selectin, ELAM, CD62E, Sele
human, mouse 1q22-q25 L L carbohydrate ligands; ESL1,CD44, CD15s, PSGL1, CD65, LAM CLECT/EGF/Sushi x6/TM NF-kB, ATF2, ATF3, c-Jun,NFAT,A20, STAT6, Smads, IL1, LPS, BLP,dsRNA, TNFa, LTa, TRAIL, radiation, IL4, IL1Ra, C5a, glucocorticoid, IFNg, TGFb, JNK, MEKK1, TMSUVB, NO, flavonoids, cAMP, PPAR, PMA, tat

P-selectin, GRMP, CD62P, Selp
human, mouse 1q23-q25 L L PSGL-1, CD15, CD15u, CD24, CD162 CLECT/EGF/Sushi x9/TM NF-kB, Bcl-3,STAT6, TNFa, Fas, LPS, trauma,IL4, MCP1
siglec, other  CD23, low aff. IgE RII, FCER2
human 19p13.3 L
IgE, CD21, CD11b, CD11c cc/CLECT CBF1 BAFF, IL4, Notch2, EBNA2, CD72, Blimp1 B

DC-SIGN, CD209
human, mouse 19p13

high Man, Mt, CMV, EbolaV, SIV, HIV gp120, ICAM2, ICAM3 CLECT
IL13 lymph. DC

LSIGN, DCSIGNR, CD209L
human 19p13
1 high Man, EbolaV TM/CLECT

lymph. DC

SCGF
human 19q13.3


CLECT TNFa bm


CD72, Lyb2
inhibit
human 9p11.2 1
CD5, SHP1, CD100 ITIM/TM/cc/CLECT PU.1
B

CD69, Leu23
induce
human, mouse, rat, pig, bovine, 12p13-p12 L 1 G,Ha-Ras TM/CLECT AP1 TNFa, IL2, IL7, IL12, IL15, TCR/CD5/CD28, PMA, IFNab, IFNg, GM-CSF, Thrombin, CpG, dsRNA, estrogen, PKC, IL4, LPS, Raf1,Vav2, Ha-Ras B, T, NK

MAFA, KLRG1
human, mouse, rat, 12p12-p13

SHIP, Dok, Fc e RI, Man ITIM/TM/CLECT
MHC-I, Tg mast cell, CD8+

NKG2-(A, B), KLRC1, CD159a
human A,B 12p13

CD94, HLA-E, SHP1,2 ITIM/TM/CLECT

NK

NKG2-C, KLRC2
human, mouse 12p13.2-p12.3

DAP12 ITAM/TM/CLECT

NK

KLRC4, NKG2-(D, F), KLR
human D, F, mouse, rat(NKR-P2), pig, 12p13.2-p12.3

MICs, DAP10, DAP12, UL16 ITAM/TM/CLECT L IL2, IL4, IL5 NK, T

NKG2H, KLRC3
human E, H 12p13


?/TM/CLECT

NK

Ly-49A, KLRA1, LY49L
human, mouse 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 ,13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23 12p13-p12


/TM/CLECT TCF1 B-DNA

LLT1
human 12p13


TM/CLECT

T

KLRD1, CD94
induce
human 12p13

HLA-E(MHC-I), CD159a, DAP12 CLECT
IL2, IL12, IL15, IL21, TCR, androgen NK

NKR-P1A, CD161, KLRB1
human 12p13-p12

CD1d, FcRgamma TM/CLECT
IL2, IL12, IL21, TCR NK, T

dectin-1, CLECSF12
human 12p13.2-p12.3

b-glucan TM/CLECT
GM-CSF, IL4, IL10, IL13 APCs, anti-Candida

OLR1
human 12p13-p12

Ox-LDL cc/CLECT
Ye

AICL, CLECSF2
human 12p13-p12


TM/CLECT
IFNa/b, PMA NK, APCs

mincle, CLECSF9
human, mouse 12p13.32


CLECT NF-IL6 LPS, TNFa, IL6, IL13, IFNg, hsp65 ganglion

CLL1
human 12p13.2


TM/CLECT



DLEC, BDCA2, CLECSF11
human 12p13.2-p12.3


CLECT



KLRF1, NKp80
human 12p12.3-13.2


ITIMx2/TM/CLECT

NK

CLEC1
human 12p13.2


TM/cc/CLECT



CLECSF1
human 16q23


CLECT



MDL1, CLECSF5
human 7q33

DAP12 ITIM/TM/CLECT

myeloid

CLEC6, CLECSF8

human, mouse 12p13.32


TM/CLECT
NRF2

DCIR, LLIR, CLECSF6
human 12p13


ITIM/TM/CLECT
IL13 APCs

CLEC6A, CLECSF10

human
12p13





LPS, Sm

CLEC2
human 12p13


CLECT FKHR Akt

langerin/CD207
human, mouse 2p13


TM/cc/CLECT
GM-CSF, TGFb1, IL4

REG1A, PSPS
human, mouse 2p12





pancreas

REGL, PSPS2, REG I beta
human 2p12


CLECT

pancreas

REG-IV
human 1q12-q21


CLECT

pancreas

tetranectin, TNA
human, mouse 3p22-p21.3 1
sulfated PS CLECT

lung

HML2, CLECSF13
human 17p13.2

Gal/GlcNAc TM/cc/CLEST/YENF



ASGR1
human, mouse 17p13.2

asialoglycoprotein TM/CLECT

liver, preDC

ASGR2
human, rat 17p13.1

asialoglycoprotein TM/CLECT

liver, preDC

BIMLEC
human 2q24.2


CLECT/TM

APCs

chondrolectin, MT75, PRED12, CHODL
human, mouse, rat 21q11.2


CLECT/TM

testis germ cell
ManR MRC1
human, mouse 10p13


RICIN/FN2/CLECTx8/TM PPARg IL13, HCV, D3

ENDO180, MRC2 
human, mouse 17q22

N-GlcNAc, MMP13 RICIN/FN2/CLECTx8/TM



DEC205, Ly75
human, mouse 2q24


RICIN/FN2/CLECTx10/TM
Fas, camptothecin
, LPS, hsp65, D3
Thy

PLA2R1
human 2q23-q24

PLA2 RICIN/FN2/CLECTx8/TM



MBL2, MBP1,
human 10q11.2-q21
L mannose CLECT TNFa, KF1B


PRG2
human 11q12


CLECT

s. muscle

PRG3, MBPH
human 11q12


CLECT
IL5
bm
anchor thrombomodulin, THBD

human, mouse, rat, rabbit, bovine, 20p11.2 1
thrombin CLECT/EGFx6/TM 1 RA, estrogen,cAMP

C1QR, C1QR1

human, mouse 20p11.21

C1q CLECT/EGFx6/TM
EV71, camptothecin

TEM1, endocialin
human, mouse 11q13


CLECT/EGFx3/TM

adipocyte
collectin PSAP, SFTP1, SPA1, SFTPA1
inhibit/ *
human, mouse 10q22.2-q23.1 1
TLR2 Collagen/CLECT
NF-kB, IL-1, TTF1, DEX, cAMP, CBP/p300, SRC1

SPA2, SFTPA2
human 10q22-q23


Collagen/CLECT



CL-L1, COLEC10
human 8q23-q24.1


Collagen/CLECT



MGC3279
human 2p25.3


Collagen/CLECT



SP-D, PSP-D, SFTP4, SFTPD
human 10q22.2-q23.1 1
LPS-O, LTA, PGN Collagenx2/cc/CLECT
TTF1, NF-ATs

scavenger SRCL, CL-P1, COLEC12
human 18pter-p11.3


TM/ccx3/Collagenx2/CLECT


attractin attractin, MGCA
human 20p13 zi

EGF/CUB/EGF/Kelchx4/PSIx3/CLECTPSIx2/EGF/TM
MVA
DGCR2 DGCR2
human 22q11.21


LDL/CLECT/VWC/TM


Dm CG9134, G12111, CG15358, CG7763, CG9978, CG2839, CG15818, CG9095, Lectin-galC1-P1, Gal-lectin, lectin-21Ca, lectin-24A, lectin-24Db, lectin-28C,
Dm







Ce ZK1193.2, T03F1.10, F40G9.10,B0218.8.p, W04E12.8, W04E12.6, K02F3.5, C14A6.1, B0218.6, T19E7.1, F47C12.2, F52E1.2, C54C8.7, E03H4.10
Ce







lectin MR60, ERGIC53, LMAN1
human, mouse, rat 18q21.3-q22


lectin/cc/TM
Sp
galectin galectin 1, LGALS1
induce
human, mouse, rat, bovine, sheep, chicken, Xl, zebrafish, Dm, Ce 22q13.1
L
galectin
ErbB2, Mt, estrogen, TIMP1 epithelial, activate NF-kB

galectin 2, LGALS2, MAC2
human, mouse, rat, 22q13.1

LTa
galectin AIRE IFNa/b APCs

galectin 3, LGALS3
inhibit
human, mouse, rat, rabbit, 14q21-q22 1

galectin Ets1 TNFa, HCV, TRAF2/TRAF5, TIMP1 CD71+, APCs

galectin 4, LGALS4
human, mouse 19q13.13


galectin

liver

galectin 6, Lgals6
mouse




Hoxd10
intestine

galectin 7, LGALS7
human, mouse, rat 19q13.13


galectin
Brn3a
epithelium, skin, tongue

galectin 8, PCTA1, LGALS8
human, mouse, rat 1q42-q43


galectin
CREB, AP1, LPS
APCs, B, T, NK

ecalectin, galectin 9, LGALS9
human, mouse, rat, 17q11.1


galectin
IFNa/b, IL3, IL12, HCV, staurosporine
APCs, bm,
activate NF-kB

galectin 12, LGALS12
human, mouse 11q13


galectin

adipocyte

galectin-13, PP13, PLAC8
human 19q13.1


galectin STAT4
IL12 placenta

Grifin
mouse, rat



galectin

eye
fibrinogen-related ficolin 1, FCN1
human, mouse, rat 9q34


collagen/FBG

APCs

ficolin 2, p35, L-ficolin, FCN2
human, mouse, rat 9q34

GlcNAc collagen/FBG

liver

ficolin 3, H-ficolin, Hakata antigen, FCN3
human 1p35.3

GalNAc, GlcNAc FBG

liver, lung

Saccharide Transferases
group name apoptosis species locus KO 3D structure upstream regulators memo
glycosyltransferases a(1,2), FUT1, Hh
human, mouse, rat, bovine 19q13.3 1
glycosyltransferases c-Myc endothelium, CD71+

a(1,3), FUT2, Se
human 19q13.3 L
glycosyltransferases


FUT3, Les
human 19p13.3

glycosyltransferases


a(1,3), FUT4, CD15
human, mouse, rat, bovine 11q21

glycosyltransferases
granulocytes, bm

a(1,3), FUT5
human, bovine 19q13.3

glycosyltransferases
heart

a(1,3), FUT6
human 19p13.3

glycosyltransferases
kidney

a(1,3), FUT7
human, mouse, 9q34.3

glycosyltransferases
DC

a(1,6), FUT8
human 14q24.3

glycosyltransferases


a(1,3), FUT9
human, mouse, rat, bovine 6q16

glycosyltransferases


a(1,3), FUT10
human, bovine 8p12

glycosyltransferases


MGC33202
human, mouse, rat 10q22.3




galactosyltransferase B4GALT1 enhance human, mouse, Dm, Ce 9p13 L 1 galactosyltransferases TNFa, FAK, cycloheximide

B4GALT2
human, mouse, bovine 1p34-p33





B4GALT3
human, mouse 1q21-q23



DC

B4GALT4
human, mouse 3q13.3



NK

B4GALT5
human, mouse 20q13.1-q13.2





B4GALT6
human, mouse, rat 18q11



(brain)

B4GALT7
human, mouse 5q35.2-q35.3





chondroitin synthase 1, CHSY1
human, 15q26.3



placenta

chondroitin synthase 2, CHSY2
human, 5q31.1





chondroitin beta1,4 N-acetylgalactosaminyltransferase, ChGn
human 8p21.3



thyroid

GALNACT-2
human 10q11.21





FLJ25045
human 11p15.5





FLJ40362, B4GalNac-T3

human 12p13.33




Complement and Related Proteins
 
group name apoptosis species KO locus structure binding partners 3D gene regulators memo
C1q C1q alpha
promote
human, mouse 1 1p36.3-p34.1 Collagen/C1q IG,C1q,  C1s, C1r, fibronectin, PTX3
NRF2, CSV-B3, Tc heart, lung

C1q beta
human, mouse, rat
1p36.3-p34.1 Collagen/C1q

Tc heart, lung

C1q gamma
human, mouse
1p36.11 Collagen/C1q


heart, lung

C1QTNF1, GIP, CTRP1, ZSIG37
human, mouse
17q25.3 Collagen/C1q


s. muscle

C1QTNF2, CTRP2, zacrp2
human
5q33.3 Collagen/C1q




C1QTNF3, CTRP3, CORS26,
human
5p13-p12





C1QTNF4
human
11q11



brain

C1QTNF5, CTRP5
human, mouse
11q23.3



lung

C1QTNF6, CTRP6, ZACRP6
human
22q13.1





C1QTNF7, CTRP7, ZACRP7
human, mouse
4p16-p15





C1ql
mouse





brain

adiponectin, APM1, ACRP30, GBP28
human, mouse, rat
3q27 Collagen/C1q

ADD1, SREBP1c, PPARg, IL6
adipocyte
C1r C1r
human, mouse
12p13 CUB/EGF/CUB/Sushix2/Trypsin
1 NRF2, IFNa, FSH, HCV, camptothecin, ribavirin liver, adipocyte

C1s
human, mouse (& B) 1 12p13 CUB/EGF /CUB/Sushix2/Trypsin
1 TNFa, IFNg, VEGF, LPS liver, adipocyte,
cleave C2, C4

MASP1, MASP, RaRF, CRARF, PRSS5, CRARF1

human, mouse, rat 1 3q27-q28 CUB/EGF /CUB/Sushix2/Trypsin MBL

liver

MASP2
human, mouse 1 1p36.3-p36.2 CUB/EGF /CUB/Sushix2/Trypsin MBL

liver, cleave C2, C4

C1RL, C1r-like, C1rlp, LOC51279
human, mouse
12p13.31 CUB/Tripsin

STAT3, STAT5B, NF-IL6, Smads, IL1, IL6, TNFb, DEX, liver, PBL

haptoglobin, HP
human
16q22.1 CUB/Tripsin hemoglobin

liver
C2 C2
human, mouse, rat, 1 6p21.3 Sushix3/VWA/Trypsin

CD3/CD28, IL1, IFNa, IFNg liver

Factor B, BF
human, mouse, frog, zebrafish
6p21.3



liver
C3 C3
human L, 19p13.3-p13.2 A2M/ANATO/A2M/NTR factor B, (CR1, CR2) 3d NF-kB, EWS/FLI-1, TNFa, IL1, IL13, RA, LPS, hsp65, Pg, Hp, HCV, HOXD3, GCSF, IL10, Stat4, calcineurin liver

C4a
human L 6p21.3 A2M/ANATO/A2M/NTR

p53, EV71 liver

C4b
human
6p21.3 A2M/ANATO/A2M/NTR

NF-kB, PMA, Ct liver

C5
(-)
human L 9q32-q34 A2M/ANATO/A2M/NTR
5a,
liver, targets
C6 C6
human, mouse, rat, Xl L 5p13 TSP1x2/LDLa/MACPF/TSP1/Sushix2/FIMACx2


liver

C9
human, mouse, rat, rabbit, fugu
5p13 TSP1/LDLa/MACPF/TSP1/Sushix2/FIMACx2 CD59
MDP liver

C7
human, pig
5p13 /LDLa/MACPF/TSP1/Sushix2/FIMACx2


adrenal, ovary, lymph.

C8 alpha
human, rabbit
1p32 TSP1/LDLa/MACPF/TSP1 CD59

liver

C8 beta
human, mouse
1p32 TSP1/LDLa/MACPF


liver
C8g C8 gamma
human
9q34.3 Lipocalin


liver
perforin perforin, cytolysin
human, mouse, rat L 10q22 MACPF/C2 C5a,
IL2, IL4, 4-1BBL, CD30, Notch, Sd, RA, Progesterone, PKC, STATs, Ets, Sp1, CsA/FK506
C1qBP C1qBP, HABP1
human
17p13.3 MAM33 C1q,SF2

preB
7TM C3aR
human, mouse, rat 1 12pter-p13.31 7TMx2 C3a
GCSF, LPS, EV71, IL13
NK, preDC

C5R1, C5a ligand, CD88 enhance human, mouse, rat 1 19q13.3-q13.4 7TM
1 RANTES, LPS, IL6, IFNg preDC, targets
Sushi MCP, CD46
human, mouse 1 1q32 Sushix4/TM C3b, C4b, measles virusHHV-6 gH 1
Tr1

CD35, CR1
human L 1q32 Sushix30/TM CD3b, C4b, IgG, IgD, IL2, malaria 1 IL2, IL4, IL8, TNFa, LTa, BAFF, AML1, hypoxemia, D3  induce NF-kB

DAF, CR, CD55
human 1
1q32 Sushix4 CD97, echovirus 7, EV70, CB3, LPS
FKHRL1, PMA, EV71 B, myeloid

CR2, CD21 inhibit human L 1q32 Sushix15 C3d, CD23, CD19/CD81
NF-kB, c-Myc, BAFF, Hp, Mt, Sp, Sp1, USF1 tonsil, lymphnode, B

C4BPalpha
human
1q32 Sushix8 Protein S, CD40
HNF1, androgen, NF-kB, TNFa, IL1, IL6,Galectin-7 liver, lung

C4BPbeta, C4BPB

human
1q32 Sushix3

HNF-3, NF-I, ErbB2 liver

Factor H, HF1
human
1q32 Sushix20 C3 convertases L IL10/LPS liver

FHR1, CFHL, HFL1

human
1q31-q32.1 Sushix5


liver

FHR2, HFL3
human
1q31-q32.1 Sushix4


liver

FHR3
human
1q31-q32.1 Sushix5


liver

FHR4
human
1q31-q32.1 Sushix5


liver

FHR5
human
1q22-q23 Sushix8


liver
Factor I Factor I, IF

human
4q25 KAZAL/SR/LDLax2/Trypsin


liver
LU CD59, protectin, MIC11
human, mouse, rat, rabbit, viruses L 11p13 LU CD2, C8alpha, C9, Hp L p53, TNFa, CREBSTRA13, androgen, PMA, Tprim., IFNa,PDGF,

ARS, component B


8q24.3 LU


tongue

E48, LY6D

human
8q24-qter LU

Hoxc8Hp
, D3
tongue

PSCA
human
8q24.2 LU

PMA prostate

G6C
human
6 LU




G6E
human
6p21.3 LU




SLURP-2, LYNX1
human
8q24.3 LU



Antibacterial peptides (partial list)
group name species locus KO gene 3D gene regulators memo
a defensin a1/HNP-1, DEFA1
human 8p23.2-p23.1


C/EBP, c-Myb,Nef, TCR/CD3/CD28, IL15, RA, Nod2
neutrophil, processed by matrilysin

a3/HNP-3, DEFA3 human, 8pter-p23.3


IFNa neutrophil

a4/Def.4,,DEFA4 human 8p23


IFNa
neutrophil

a5/Def.5, HD-5, DEFA5
human 8pter-p21



neutrophil

a6/Def. 6, DEFA6 human 8pter-p21



neutrophil
b defensin b1, DEFB1
human 8p23.2-p23.1



kidney, liver, prostate, salivary gland, constitutive

b2, hBD-2, DEFB4, SAP1, DEFB102 human 8p23.1-p22
1 L bacteria, Hp, LPS, FliC,NF-kB,IL-1, IL17, TNFa salibarygland, kidney, tongue

DEFB103A, HBD3, HBP3, DEFB3, HBD-3, HBP-3, human 8p23


corticosteroids

DEFB104, DEFB4, DEFB-4
human
8p23






DEFB105, BD-5, DEFB-5
human
8






DEFB106, BD-6, DEFB-6
human
8p23-p22






DEFB107, DefB-7
human 8p23-p22






DEFB108, DefB-8
human 8p23-p22






SPAG11, EP2, HE2, EP2C, EP2D human 8p23-p22





DEFQ1, Def-theta1
human
8p23.1




bone marrow, lymph node, thyroid

DEFB118, ESC42, DEFB-18
human
20q11.1-q11.22




testis

DEFB119, DEFB-19, DEFB-20, DEFB120
human
20q11.1




testis

DEFB123, DefB-23
human
20q11.1





DEFB124
human
20q11.1




testis

DEFB125
human
20p13






DEFB126
human
20p13




testis

DEFB127
human
20p13






DEFB129
human
20p13






UNQ827, KFLL827, DEFB32
human
20p13





cathelicidin cathelicidin, FALL39, CAP18, CAMP
human,mouse 3p21.3

1 St, LPS, IFNa, IL5, IL-6, RA bone marrow, PMN, processed by proteinase-3
hepcidin hepcidin, HAMP, LEAP1 human, mouse 19q13 1
1 iron, C/EBPa, USF2, hypoxia liver
Tandem gene information; 6p21[b110-114] 20p13[b125>b26(ESP13)>b127>b129] [], 8p23 [b1<a6<a4<a1<T1<SPAG11<b104<b106<BD5], 20p13[b125>b26(ESP13)>b127>b129], 20q11.1[b118><b119<b122, b123><b124]
 

One-line review of

Antimicrobial peptides of vertebrates by Yang et al. (Annu Rev Immunol 2004), by Ganz & Lehrer (Curr Opin Immunol 1998)


IL8 Family Chemokines and Their Receptors
 
group proposed name ligand/receptor apoptosis species gene locus KO 3D gene regulators memo
CC SCYA1 I309, CCL1
CCR8
human, mouse
17p13.2
1 TCR, IL12, IFNa, IL31


CCL2 MCP1, MCAF, SCYA2 CCR2
inhibit
human, mouse, rat, bovine, rabbit,pig,dog, 1 17q11.2-q21.1 L 1 NF-kB, Sp1, C/EBPs, AP1, EGR1, Bcl6PDX1Hoxc8, NRF2, EWS/FLI-1, TNFa, LTa, TRAIL, Fas, RANKL, IL1, IL4, IL13, IL17, IFNa, IFNg, GM-CSF, IL1b/IFNg,IFNk, PDGF-BB, RA, PMA, AgII, C5aEP4, VIP, PACAP, insulin, Resistin, estrogens, Wnt1, Akt/PKB, IKKs, p38, PLC, LPS, BLP, LTA, PGN, KF1B, MDPOX-CA, Bm, Ec, St, Sa, Lm, Mt, Pg, Tc, TBhsp70, BCGhsp65, flagellin, BCG, Cp,Hp, Pa, Tg, dsRNA, HCV, RSV, AdV, HHV8, UVB, shear stress, RANTES, SCF, VEGF, plasmin, p38, Cannabinoid, doxorubicin, Alprazolam, Bmp6, Bmp7, estrogen, PGE2, Gab2, EP4, BMP2, IL10, AgII, IKKs, SOCS1


CCL3 MIP1a, LD78, SCYA3 CCR1, 5 inhibit/promote human, mosue, rat, chicken
17q11-q21 L 1 NF-kB, C/EBPs, Ets2, p53, PPARg, IL3, IL2, IL6, IL15, GM-CSF, Ets, serum, TNF, FasL, Fas, RANKL, CD40, IFNk, XNA,VIP, PACAP, LPS, PGN, MDP, TBhsp70, LTAb-glucan, BCGhsp65, BCG, Ec, Ld, Lm, Ma, Mt, Sa, Sm, St, g-irrad, NO., PMA, FceRI, CD3/28, BCR, CD43,Nef, CD3&IL2, Bcl6, RANTES, RA, D3, PGE2, Rac2, AmB, camptothecin, ribavirin

CCL3L1 LD78-beta

human
17q11.2

PMA

CCL4 MIP1b, ACT2, LAG1, SCYA4 CCR5
promote
human, mouse, rat, rabbit
17q21
L CREB, LPS, CD40, TNF, RANKL, FasL, IL1, IL3, IL10, IL2, IL12, IL15, IL31, GM-CSF TCR/CD3/CD8/CD28, BCR, XNA, PMA, CD43, MIP3, Subst.P, CD3&IL2, MDP, flagellinb-glucan, BLP, Bm,,Hi, Ld, Lm, Ma, Mt, Sa, Sp, g-irrad., HCV, Nef, dsRNA, CpG, OX-CA, Cannabinoid, CsA, estrogen, RANTES, SCF, D3, PGE2, AmB, ribavirin

CCL4L1
LAG1, LAG-1, SCYA4L, AT744.2


human

17q12





CCL5 RANTES, SCYA5 CCR1,3,5 inhibit/promote human, mouse,rat, bovine 1 17q11.2-q12 1 L NF-kB, IRF1, IRF3, IRF7, AP1, AIRE, RFLAT1, HSF1, IL1, IL2, IL17, TNF, CD40, CD8/28, LTa, RANKL, IFNs, IL12, TCR, M-CSF, GM-CSF, VIP, PACAP, LPS, PGN, MDP, LTA, Bm, Hp, Ld, Lm, Mt, Tg, Ct, Ma, Mt, Pg, Yp, dsRNA, EV71, VLP, CD28, BCR, IFNg, IL17, SCF, EP4, BRCA1, PMA, RSV, IKKs, IKKi, TBK1, TAK1, JNK, CFTR, DEX, estrogen, androgen, D3, EP4, IKKs targets

CCL6 c10, MRP-1, SCYA6

mouse



Hf ,Sm

CCL7 MCP3, SCYA7 CCR1,2,3
human, mouse,rat
17q11.2-q12
L NF-kB, Hoxc8, b1-integrin, b-catenin, TRAIL, IL1, IL17, TNFa, RANKL, VEGF, PMA, Bcl6, insulin, NO, BLP, Bm, Ld,, Lm, Mt, Pg, Sp, Tg, VLP, DEX, BMP2, IL10, IKKs, camptothecin, cantharidin, ALA, SOCS1


CCL8 MCP2, SCYA8 CCR3
human,mouse, pig,bovine
17q11.2
1 IFNg, IL1, RANKL, LPS, PGN, Lm, Mt, Tg, VLP


CCL9 MIP-1 gamma, SCYA9

mouse



NF-kB, NRF2, PPARg, AIRE, TNF, RANKL, IL1, LPS, D3


CCL11 eotaxin 1, AI1, SCYA11 CCR3
human, mouse, rat, pig, house,bovine
17q21.1-q21.2 L L NF-kB, STAT6, IL13, TNFa, IL1b, IFNg, IL4IL9, IL25, LPS, PGN, LTA, Lm, Mt, VLP, glucocorticoid, TGFb1, estrogen, HuR, A2aR

CCL12 MCP5, eae7, TCA-3, SCYA12

mouse



LPS, CpG, Lm, IFNabR1, TRIF

CCL13 MCP4, NCC1, SCYA13 CCR2,3
human
17q11.2

TNFa,TRAIL, IFNg, IL4, PGN, glucocorticoid, RA

CCL14 NCC2, SCYA14 CCR1
human
17q11.2
1 IFNa, TNFa, c-Myc, IL1,ALK1, TGFR1

CCL15 MIP1d, NCC3, leukotactin, MIP5, SCYA15 CCR1,3
human
17q11.2

ALA

CCL16 NCC4, SCYA16 CCR1
human
17q11.2

SCF

CCL17 TARC, SCYA17 CCR4
human, mouse
16q13

TNFa, IFNg, IL10, IL25, IL31, SCF,LPS, Lm, Mt, Tg, BMP2

CCL18 PARC, AMAC1, DC-CK1, SCYA18

human
17q11.2

IL10, D3, TCR/CD3, LPS, Ca,Mt, Sa, influenza v, TNFa, CD40L,IFNg,

CCL19 MIP3b, exodus-3, CCL19, ELC, SCYA19 CCR7
human, mouse
9p13

IL31, Ma, LPS


CCL20 MIP3a, exodus-1, CCL20, Larc, SCYA20 CCR8
human, mouse, rat
2q33-q37

NF-kB, Sp1, ESE1, EWS/FLI-1, IL1, TNFa, LTb, PMA, LPS, PGN, Bm, Ld, Lm, Mt, Tg, Ye, flagellin, UVB, hypoxia, D3, MEK1, camptothecin, ALA


CCL21 SLC, exodus-2, SCYA21 CCR7
inhibit
human, mouse(a,b,c)
9p13

SCF, Prox1, PMA

CCL22 MDC, STCP-1, SCYA22 CCR4
human, mouse
16q13

IL1b, SCF, IL12, IL13, IL31

CCL23 MPIF1, Ckb-8, SCYA23 CCR1
human
17p13.2
1 IL31, Mt, LPS

CCL24 eotaxin 2, MPIF2, SCYA24 CCR3
human, mouse
7q11.23
L LPS, IL-4

CCL25 Teck, SCYA25 CCR9
inhibit
human, mouse
19p13.2

VDR, Egr1, AIRE

CCL26 eotaxin 3, SCYA26 CCR3
human
7q11.2

STAT6,IL4, IL13, TGFb


CCL27 CTACK, ILC, ALP, Eskine CCR10
human, mouse
9p13

TNFa, NRF2, PMA

CCL28 CCL28 CCR3, CCR10
human, mouse
5



CXC CXCL1 Groa, Gro1, MGSA, SCYB1, KC
CXCR2
human, mouse
4q12-q13
1 NF-kB, NF-IL6, Sp1, HMG-I, C/EBP, PPARg, EWS/FLI-1, TRAIL, TNFa, IL1IL17, IL31, XNA, VEGF, insulin, LPS, PGN, KF1B, MDP, BLP, LTA, Ec, Ld, Lm, LLO, Mt, Pg, St, Sa, Tg, Ye, hsp70, hsp65, flagellin, BCG, AdV, UVB, HHV8, VLP, BMP2, IL10, Wnt3a,

CXCL2 MIP2, MIP2a, Grob, Gro2, SCYB2 CXCR2
human, mouse
4q12-q13
1 NF-kB, c-Myc, PPARg, EWS/FLI-1, IL1, IL17, TNFa, FasL, RANKL, XNA, PMA, C5a, GM-CSF, LPS, BLP, PGN, KF1B, MDP, LTA, R848, Bm, Cd, Ct, Ec, Hp, Ma, Mt, Ld, Lm, Pg, Sa, Sd, St, Tg, Ye, flagellin, HCV, RSVdsRNA, VLP, FVIIa, DEX, NO, hypoxia, Subst.P, VIP, PACAP, UVB, estrogen

CXCL3 MIP2b, Grog, SCYB3 CXCR2
human
4q21

IL1, TNFa, LPS, PGN, MDP, LTA, Bm, Hp, Ld, Lm, Mt, St, Tg, Ye, flagellin, HHV8, UVB, DEX, D3

CXCL4 PF4, SCYB4
inhibit human, mouse

4q12-q13

Ets1, GATA1, PDX1, IL6

PF4V1
PF4A, CXCL4V1, PF4-ALT, SCYB4V1


human

4q12-q21





CXCL5 ENA78, SCYB5, LIX
CXCR2
human, mouse

4q12-q13

AIRE, GCSF, IL1, IL17, TNF, BMP2, LPS, hsp65, Hp, Hf, Mt, Pg, VLP
induces NF-kB

CXCL6 GCP2, SCYB6 CXCR1,2
human
4q12-q13

EWS/FLI-1, IL1, TNFa, BAFF, IFNg, PGN, DEX

CXCL7 proPBP, CXCL7, (CTAP3, TGb, NAP2, TC1, TC2), SCYB7, PPBP CXCR2
human, mouse

4q12-q13

PU.1, IL1b/TNFa, Pg


CXCL8 IL8, see ILs CXCR1, 2





PGN, IL1


CXCL9 MIG, SCYB9 CXCR3
human, mouse

4q21

STAT1, NF-kB, CBP, IFNg, B-DNA, PPARg, TNF, EP4, IL12, IL10, Hf, Hp, Lm, Mt, Pg, Tc, Tg

CXCL10, SCYB10 IP10, INP10, Mob1 CXCR3
(-)
human, mouse
4q21 L
NF-kB, Hoxc8, IL1, TNF, LTa, Fas, IFNa, IFNb, IFNg, IL4, VEGF, Subst.P, EP4, cholecystokinin, CpG, LPS, BLP, Ec, Pg, St, Sa, Lm, Mt, Tg, TBhsp70, BCGhsp65, BCG, dsRNA, HCV, MV, AdV, HHV8, VLP, PGE2, estrogen, STAT1, PPARg1, IFNabR1, TRIF, MyD88

CXCL11 IP9, ITAC, CXCL11, SCYB11 CXCR3
human
4q21.2

TNFa, IFNa/b, IFNg, PPARg, LPS, B-DNA, Mt, Tg, TRIF

CXCL12 SDF1, pre-B, CXCL12, SCYB12 CXCR4 induce/inhibit human
10q11.1 L L NF-kB, TNFa, CD8/28, Wnt1, Hf, Hi, VLP, IL3, ERPTEN, IKKs, estrogen targets

CXCL13 BLC, BCA1, CXCL13, SCYB13 CXCR5
human
4q21 L
A2aRLPS, Hp, IL10


CXCL14 BRAK, SCYB14

human, mouse
5q31

AIRE, HCV, estrogen


CXCL15 Lungkine

mouse

1




CXCL16 SRPSOX CXCR6
human, mouse
17p13

PGN, IFNg, TNFa, Pg
induce NFkB

XCL1,  SCYC1 XCL1, SCM1, SCM1a, lymphotactin XCR1 promote human, mouse
1q21-q25

CsA/FK506, CD3&IL2, PMA, VLP, Pg, androgen

XCL2, SCYC2 XCL2, SCM1b XCR1
human
1q23



CX3CL
CX3CL1, SCYD1 Fractalkine, Neurotactin (NTN) CX3CR1
human, mouse, rat
16q13

NF-kB, NRF2, PDX1, IL1, IFNg, TNFa, SCF, FSH, St, flagellin, EP4, IKKs, androgen
CCR (7TM) CCR1 CKR1, HM145, CMKBR1 CCL3, 5, 7, 14, 15 ,16 ,23
human, mouse
3p21 L
NF-kB, ARNT2, TNFa, RANKL, IFNa/b, IFNg, IL-2, IL5, IL6, IL8, PMA, IL15, LPSb-glucan, Lm, CD3/28, RANTES, IL10, D3, ErbB4 APCs
(G-coupled) CCR2 CKR2, CMKBR2 CCL2(MCP1), 12,13,
(inhibit)
human, mouse
3p21 L
IL2, IL15, IFNa, RANKL, Lm, TcNF-kB, PMA,GCSF, SCF, estrogen, D3
APCs

CCR3 CKR3, CMKBR3 CCL5(RANTES), 6, 8, 11, 13, 15, 24, 26
human, mouse
3p21.3 1
IFNg, IL2, IL3, IL4, IL25, estrogen eosinophil

CCR4 CKR4, CMKBR4 CCL17, 22(Tarc, MDC)
human, mouse
3p24 L
BCR, IL18, G-CSF


CCR5 CCCKR5, CKR5, CD195 CCL3, 4, 5 (MCP2, MIP1a, MIP1b)
mediate
human,mouse
3p21 L
NRF2, TNFa, IL6, IL12, TCR, PMA, BCR, Lyn, IFNg, M-CSF, Tc, EV71, IL10, D3, Rac2, rapamycin
APCs/T,  HIV-1 coreceptor

CCR6 CKRL3/GPR29/GPRCY4/STRL22/CMKBR6 CCL20(MIP3a,)
human, mouse
6q27 1
AIRE, IL10, IL4, IFNg, LPS, MDP, hypoxia/CD3 B, Sd

CCR7 EBI1, CMKBR7, CD197 CCL21 inhibit
human, mouse
17q12-q21.2 L
NF-kB, IL18Notch, LPS, Bm, Ld, Lm, Mt, Tg, VLP, PMA, DAP12, TREM2, estrogen, D3
B/T

CCR8 CKRL1/CMKBR8/CMKBRL2 CCL22 (T