Index Caspase CARD/DED/BIR Bcl-2  DD TNF/TNFR Kinases ILs Viral Lipid Engulf TF RING Toll Other Apop Other NFkB Alphabet

 
IL/FGF/IFN/GH familes
(for STATs, see here)
family name apoptosis
NF-kB
AP1 KO gene Structure 3D locus TFs regulators target memo
IL1 superfamily
IL-1a (human , mouse , rat , house , dog, sheep, bovine, pig, rabbit) inhibit/enhance
activate
activate L 1 IL1 1 2q14 AIRE IL1, IL8, IL18, TNFa, RANKL, CD8/28, CD43, IFNg, GCSF, M-CSF, IL10, C3b/C4b, XNA, PMA, serum, EGF, LPS, BLP ,MDP, b-glucan, flagellinCpG, Bm, Hp, Hf, Pg, St, Ye, MVA, tax, AmB, Erks, RA, cantharidin list

IL-1b (human, mouse, rat, house, sheep, bovine, rabbit, dog, cat, pig, chicken, frog, r.trout 1,2, carp 1, 2) inhibit/enhance/(-)
activate
activate L 1 (TM)/IL1 1 2q14 NF-kB, NF-IL6, PU.1, Sp1, HSF1, IRF2, Gfi1, EWS/FLI-1, PPARg, PDX1, twist2 LPS, BLP, MDP, b-glucan, hsp65, Bm, Cp, Ct, Ec, Ft, Ld, Lm, Hi, Ma, Mt, Sa, St, Tg, flagellin, BCG, dsRNA, CpG, EBV, HHV8, Tax, CMV IE2, VLP, IL1, IL5, IL16, IL18, IFNa, IFNb, IFNg, FVIIa, CD8/28, XNA, PMA/IoCD43, MHC, TNFa, Fas, RANKL, CD40, Wnt3a, C3b/C4b, bradykinin,C5a, SCF, histamine, CRH, DEX, D3, PGE2, UVB, HSF1, RANTES, CXCL5, IL2, IL10, AgII, TGFb1, PAF, lactoferrin, Rac2, FADD, JNKs, AmB, mechanically, List, SAA casp 1

IL-1Ra (human,mouse)
inhibit,(-)
inhibit
inhibit L 1 IL1 1, R 2q14.2 NF-kB, STAT3, STAT6, PU.1 IL-4, IL10, IL13, CD3/28/TCR, XNA, TNFa, GM-CSF, SCFPTH, LPS, PGN, MDP, SpMVA, hypoxia, Raf-1, p38, HCMV IE1, leptin, BMP2, BMPs; ATP/P2X7
INAP , TNFa,

IL-18, IGIF(human, mouse, rat, Ap, chick)
enhance
activate
activate L 1 (TM)/IL1
11q22.2-q22.3 AP-1, Elf-1, IRF1, ICSBP, Bcl6 IFNa, IFNg, ACTH, TSH, TRH, PMA, LPS, Cp, Hf, Pg, Sd, VLP, estrogen, androgen, RON/MSP, TRIF, M-CSF, IL10
IFNg, FasL casp 1

FIL1d, IL1RP3, IL1HY1, IL1F5 (human)



1 IL1
2q14.2




FIL1e, IL1e, IL1F6 (human)  
induce
induce
1 IL1
2q12-q14.1




FIL1zeta(human), IL1H(L,S), IL-1X, IL1F7



1 IL1
2q12-q14.1
PMA
binds IL18R, IL18BP

FIL1eta, FIL1, IL1F8 (human)  
induce
induce
1 IL1
2q12-q14.1




IL-1H1, IL1RP2, IL1F9 (human)  
induce
induce

IL1
2q12.1
ALA



IL1F10 (human)




IL1
2q14.1




FGF1/acidic FGF(human, mouse, pig)
inhibit
activate

1
IL1 L 5q31 IRF3
IL2, actins, FR17, estrogen


FGF2/basic FGF(human, mouse, sheep, frog)
inhibit


L
IL1, FGF family L 4q26-q27 E2F1, p53, AP1, Egr1, HOXB7 OSM, IL1, TNFa, PMA, serum, hypoxia, AgII, Ye, heat, density, PTH, FSH, cAMP, NAcR, I3C, ribavirin, list, actins, NGFR, a1, osteocalcin, elastin, LDL-R, D-cyclin, PGHS-2, FGFR1, integrin, IGF-IR, b-amyloid, i.collagenase anti-BMP4 function

FGF3/INT2/(human, mouse, frog, zebrafish)


L
FGF family
11q13
RA, cAMP
inner ear, skeletal

FGF4/HSTF1/HST/KFGF(human, mouse, bovine, chicken, frog II)
inhibit


L
FGF family
11q13 NF-Y, Sp1
progesterone, b-catenin FGFRs, prolactin inner cell mass, anti-BMP4 function

FGF5 (human, mouse)


L
FGF family
4q21
SCF, FSH
hair growth

FGF6/HST2(human)


1
FGF family
12p13
MDP, cisplatin


FGF7/KGF(human, mouse, sheep, dog)
inhibit


L
FGF family 1 15q15-q21.1
estrogen, SCF, Subst.P, LPS, Pg



FGF8/AIGF(human)
regulate


L
FGF family
10q24
androgen
limb formation, gastrulation

FGF9(human, mouse, rat, frog)
inhibit


L
FGF family
13q11-q12 HOX11
MDP, Subst.P, LPS, MVA
lung branch, sex

FGF10 (human, mouse, rat)
inhibit

induce
L
FGF family
5p13-p12 Tbx4
TGFb

multiorgan

FGF11, FHF3(human, mouse)




FGF family
17p13.1




FGF12, FHF1(human)




FGF family
3q28 CREB



FGF12B(human, mouse, rat)




FGF family
3




FGF13 (human, mouse)




FGF family
Xq26.3 Brn3a



FGF14/FHF4(human, mouse)


1
FGF family
13q34
LPS


FGF15 (mouse, rat)




FGF family


Subst.P


FGF16(human, mouse)




FGF family
8p21.3




FGF17(human, mouse)


1
FGF family
8p21
ARNT2
cerebella

FGF18(human, mouse, rat)


L
FGF family
5q34




FGF19(human, mouse)




FGF family
11q13.1
ALA



FGF20(human, mouse, rat)




FGF family
8p22-p21.3




FGF21(human, mouse, rat)




FGF family
19q13.1-qter




FGF22(human, mouse)




FGF family
19p13.3




FGF23(human, mouse, rat)


1
FGF family
12p13.3



beta c
IL-3 (human, mouse, rat, bovine, sheep)
inhibit/(-)
initiate

L 1

5q31.1 NF-kB, Oct1, E4BP4, NF-AT, YY1, ASRF, Egr2, Egr3, DB1 CCR3, JNK, Ma, b-glucan (activates Jak2,Stat5) T
GM-CSF, CSF2 (human, mouse, rat, sheep, pig, bovine, horse, dog, cat, )
inhibit


L

1 5q31.1 NF-kB, AP1, Elf1AML1, Ets1, Ets2, EWS/FLI-1, NF-ATp, PEBP2, PU.1, C/EBPa, HMG-I, D3R, IL1, IL2, IL7, TNFa, TWEAK, GMF, TCR/CD3/28, PMA, FceRI, CD43, TREM1, LPS, MDP, CpG, CSD, UVB, hypoxia, tax, FK506, rapamycin, lactoferrin, IFNa, IFNg, CsA, glucocorticoids, targets
gamma c
IL-2, TCGF (human, mouse, rat, cat, dog, sheep, bovine, chicken)
inhibit/(induce)/(-)
activate,*
(-) L 1 IL2 1 4q26-q27 NF-kB, AP1, CREM, AP3, ILF1, c-Myc, OCT1, NF-AT, NF-IL6, IRF4, PPARg, Elf1, PU.1, YY1, (review) TNFa, IL1, IL4, IL7, IL12, IL15, IL17, IL18, LFA-1, TCR/CD3/28/PMA, CD80, CD86, PD-1, B7H4Notch, TRH, 4-1BB, TGFb1, FGF1, MCP1, HRF, Sd, Sm, Mt, DEX, PGE2, cAMP, oxLDLs, FK506,/CsA, NAC, Monochloramine, cannabinoid, Tax, CD2, CD69, CD101, EphB6, ATP, CB1, PKCtheta, Tat, Tpl-2, Akt, Itk, TRAF5, IRAK, JNK, MEKK2, Ras, GILZ, HuR, Pim-1, SSA, Shc (activates Jak1/3,Stat1/3/5)
targets, Bcl2,NF-kB, M-CSF, c-fos

IL-15 (human, mouse, rat, dog, sheep, bovine, pig, chicken) inhibit, (-, NK)

L 1 IL2
4q31 NF-kB, AIRE tax, IL1, IL16, IFNs, GM-CSF, PD1, dsRNA, B-DNA, LPS, sBLP, MVA, RON/MSP, ribavirin, TRIF, estrogen, androgen (activates Jak1/3,Stat3/5)
targets, IL8, Bcl-xL

IL-21 (human, mouse)
inhibit/ induce




IL2
4q26-q27

(activates Jak1/3,Stat1/3/5)
IL4 (Th2)

IL-4/BSF1 (human, mouse, rat, cat, dog, sheep, bovine)
inhibit/enhance
inhibit

L 1 IL4 1 5q31.1 NF-AT, NFATx, c-Maf, NIP45, NF-Y, HMG-I, STAT6, GATA3, IRF1, IRF2, IRF4, CIITA, AP1JunB, AIRE, NF-kB, C/EBPgamma IL25, IL16, CD40, TCR, PMA, CD28, CD86, B7H2, IFNg, Jak1, Vav, PKCtheta, cAMP, Nef, EBVMDP, Sm, VLP, CsA, D3, androgen (activates Jak1/3,Stat6)
targets, Bcl2, IL6,
B act.

IL-13 (human, mouse, rat, bovine)
inhibit
inhibit
inhibit L 1 IL4 1 5q31 GATA3, IRF4, c-Myc, NF-ATs
IL25, IL12, CD3/28, PMA, Hi, Sm, nicotine, UVB, CNAIP, TSH, TGFb, HRF, TIMP1 (activates Jak1/2/3/Tyk2,Stat6)
targets

IL-5, EDF (human, mouse, rat, cat, bovine)
inhibit/enhance


L 1 IL4 1 5q31.1 GATA3, AP1, NF-AT, NFATx, Bcl6, ARNT2
IL25, RANKL, SCF, CD3/28/TCR, CD86, IL10, cAMP, PKA, PMA, flu v, CsA, OX-CA (activates Jak2,Stat5)
targets
eosinophil trafficking
gp130








IL-6 (human, mouse, rat, bovine, house, sheep, chicken, fugu)
inhibit/induce

(-) L 1 IL6 1 7p21 NF-kB, AP1, JunB, NF-IL6, CREB, EGR1, C/EBPg, C/EBPd, IRF2, CBF1, STAT3, p53, PDX1, HSF1
LIF, Fas/FasL, TNF, TRAIL, 4-1BB, CD40, IL1, IL4, IL10, IL16, IL17, IL17D, IL18, IL19, IL26, GM-CSF, IFNa, OsM, AgII,  CD8/CD28, XNA, IgE, CD43, PMA, ML-1, histamine, LTB4, Subst.P, ET-1, SST, bradykinin, SHIP, PTH, TRH, PTHrP, Thrombin, IGF2, C5a, lactoferrin, E1A, HBx, radiation, LPS, MDP, BLP, CpG, b-glucan, dsRNA, PGN, R848, MALP2, TBhsp70, BCGhsp65, Bm, Ct, Ec, Hp, Ma, Mt, Pg, St, Sa, Lm, Mt, Tg, Ye, LTA, RSV, AdV, HHV8, MVA, VLPhypoxia, heat shock, UVB, TGFb, FLT3L, microcrystals, vFLIP, CD101, cAMP, PGE2, NAC, MAIL, DEX, D3, IKKs, MAL, TRIF, RICK, Erk1/2, M2, p38, JNKs, p21, camptothecin (activates Jak1/2,Stat1/3)
Bcl2, Bax, Bcl-xL, PAF, SAA

G-CSF, CSF3 (human, mouse, cat, bovine, pig, sheep), MGF(chicken)
inhibit

activate L 1 IL6
17q11.2-q12 NF-kB IL1, IL17, LPS, MDPBLP, CpG, Ec, St, Sa, Lm, Mt, Pg, BCG, VLP, IL17F, Thrombin, Subst.P, calcineurin, tax, IL10 targets, A1
oncostatin M, OSM (human)
inhibit




LIF subfamily
22q12.2 STAT5 IL2, IL3, EPO, Fas, PMA, Hp, camptothecin (activates Jak1/2,Tyk2, Stat1/3)
LIF (human,mouse, rat, pig, sheep, dog, bovine)
enhance/inhibit


L
LIF subfamily 1 22q12.2 NF-kB TNFa, IL1, IL2, IL7, IL12, IL15, PMA, CD3/28, TGFb, LPS, Ct, Lm, Ma, St, Sd, Ye, HHV8, irrad, UVB, FVIIa, CsA, IKKs (activates Jak1/2,Tyk2, Stat1/3)
targets

IL-11, AGIF(human, mouse, rat, fugu)
inhibit
inhibit


1 IL6  subfamily
19q13.3-q13.4 AP-1, NF-kB, EWS/FLI-1 TGFb, IL1, TNFa, insulin, DEX, heparin, Mt, M-CSF, SCF, TPA, IKKs (activates Jak1,Stat1/3)

IL-12 (hIL-30uman alpha/p35, beta/p40)
inhibit/(-)/promote

induce


L a a(IL6), L IL12A (3p12-q13.2 NF-kB, AP1, AIRE, Ets2, C/EBP, EKLF, IRF1, IRF2,IRF8, Sp1, STAT4, STAT6 IFNg, IFNb, IFNk, CD40, TNFa, RANK, vitamin D3, IL4, IL6, IL10, IL13, MCP1, VIP, LPS, b-glucan, Hp, Sm, (Tg), LeIF, CD154, B7-DC, bradykinin, IL4R1, C1q, MAST205, Vpr, TRIF, curcumin, S-27609, parthenolide (activates Jak2,Tyk2, Stat4)
targets
T, NK>INFg byPBMC

L b b(FN3)
IL12B (5q31.1-q33.1) NF-kB, IRF1, ICSBP, C/EBP, STAT3, NFAT, c-Maf IL1, IL4, IL10, IFNb, IFNg, RON/MSP, LPS, CpG, Ba, Ec, Re, Pg, St, Sa, Sm, Lm, Mt, TBhsp70, VapA, HIV1, HCV core, MgHV68, BCG, CD154, DEX, apoptotic cells
IL-23 p19, SGRF(human, mouse, pig)
(inhibit)


L
IL6
+IL12b(see above)

12q13.13
IFNg, LPS, TLR4, TRIF (activates Stat4)
IL-31 (human, mouse)




1
IL6

12




IL-27, IL-30, p28 (human)




IL6
16p11

(activates Jak1/2,Tyk2, Stat1/3/4/5)
t-Bet

EBI3, IL-30 (human)




FN3
19p13.3
EBV, IFNb, TIMP1


CNTF (human, mouse, rat, rabbit, pig, chick)
inhibit


L
IL6 1 11q12.2
IL1, IL6, RA, levobetaxolol

gamma c
IL-7 (human, mouse, rat, bovine, sheep)
inhibit/(-)/induce
activate
activate L 1

8q12-q13 p53, p73 IFNg, LPS, PD1,UV, Hp, Pg, MVA, VLP, TIMP1 (activates Jak1/3,Stat3/5)
targets, IL2, Bcl2


IL-9/p40(human, mouse)
inhibit
inhibit

L 1 secreted
5q31.1 NF-kB, AP-1, CD3/CD28, Ma, b-glucan, AIRE
(activates Jak1/3,Stat1/3/5)
Bcl3
support h-T(2-/4-)
CXCL IL-8, SCYB8, NAP1, GCP1(human)
inhibit/(-)



1
1 4q12-q13 NF-kB, AP-1, NF-IL6, TCF4, TEF1, CREB, CRE-BPa, EWS/FLI-1, MEF, XBP1, NR2F2, C/EBPs, p300, TORC TNFa, IL1, Fas/FasL, TRAIL, LTb, TWEAK, 4-1BB, CD40L, BCR, XNA, CD8/28, PMA, CD43, IL5, IL12, IL13, IL17, IL17D, IL17F, IL18, IL26, GM-CSF, GCSF, VEGF, IFNg, neurotensin, VIP, histamine, LTB4, fumagillin, gastrin, lactoferrin, Ox- stress, irrad, UV, hypoxia, , NO, stretch, FVIIa, LPS, BLP, MDP, KF1B, CpG, LTA, b-glucan, Bm, Cp, Ec, Hp, Ld, Lm, Ma, Mt, Sa, Sd, Sp, St, Sp,Tg, Ye, TBhsp70, BCGhsp65, flagellin, dsRNA, BCG, EBV, HHV8, MVA, EV71, SARS, RANTES, b-catenin, estragen, DEX, RA, doxorubicin, glucose, OmpA-likeCannabinoid, CsAMEK1, MLK3, Erk1/2DRR1, p38, RICK, PKCd, PKK, ZIPK, TNFR1, TRAF6cFLIP,ACT1, CDC42, Rac1, p114, p115, C16orf15, Tid1, fibonectinHuR, PGE2, Gln, Ni3S2, AmB TNFa, Raf chemokine

For other chemokines, see IL8 family



IL-10











IL-10, CSIF (human, mouse, rat, cat, dog, bovine, sheep, pig, house)
induce/inhibit
potentiate/inhibit induce L m IL10 homodimer 1 1q31-q32 NF-kB, AP1, STAT3, GATA-3, C/EBPs, IRF1, IRF4, c-Maf, SMAD3, Gfi1 TNFa, IL1, BAFF, CD46, IL2, CD3, B7H2, PMA, TREM1IL1b/IFNg, IFNa, IFNk, IL10, FLT3L, lactoferrin, CIS3, Subst.P, LPS, BLP, , b-glucan, Ct, Ma, Py, Sm, HCV NS3, VLP, LeIF, hsp90b, TNFR2MDP/Nod2, CsA, cAMP, apoptotic cells (activates Jak1,Tyk2, Stat3)
targets, IFNg, IL2, IL3, IL12, GM-CSF, TNFa
enhance Th2
IL-19, MDA1, NG.1, ZMDA1, IL-10C (human, mouse 19A, 19B, rat)
induce




IL10  1 1q32
LPS STAT targets
IL-20 (human,mouse)




IL10 
1q32

D3, LPS
STAT3 targets
IL-22/IL-TIF(human)



1 IL10 
12q15
IL-9, LPS (activates Stat1/3/5)
STAT, SAA, a1-1-antichymotrypsin, Hpa1

IL-24, MDA-7, ST16, mob-5, C49a (human, mouse, rat)
induce
induce
induce


IL10
1q32 AP-1, C/EBP RET
STAT targets
IL-26, AK155, ML-1 (human)




IL10 
12q15

IL6, IL8
IL-28A (human)




IL10 
19q13.13
IFNa, viruses
(activates Stat2/3)
IL-28B (human)




IL10 
19q13.13

(activates Stat2/3)
IL-29 (human)




IL10 
19q13.13
IFNa, viruses (activates Stat2/3)
BCRF1(EBV), vIL-10(CMV, HPV, YDV)



1 IL10 homodimer w/sIL10R1


inhibit IFNg ind.
IFN alpha (1: human, zebrafish) inhibit/ sensitize activate


IL10 
9p22
E2F1, ARNT2
IL25, IFNa, LPS, MDP(-), dsRNA, viruses, VLP, hsp65, BDCA2, TLR7, RA, D3, androgen (activates Jak1,Tyk2, Stat1/2)
targets

IFN beta (2: human)
promote


L
IL10
9p21 AP1, NF-kB TRAIL, RANKLIL1, IL10, IFNa, BDCA2, LPS, Lm, TGFbdsRNA, viruses, VLP, NO, estrogen, hypoxia, IKKi, TBK1, TRIF, ribavirin (activates Jak1,Tyk2, Stat1/2)
targets

IFN kappa (human)




IL10 
9p21.2
dsRNA, IFNa, IFNb

IFNg IFN gamma (human, mouse, rat, rabbit, dog, horse, bovine, sheep,chicken)
induce


L


12q14 IRFs, AP1, STAT3, STAT4, t-Bet, Hlx, GATA-3, IRF2, NFATx virus, VLPs, IL1, IL2, IL4, IL10, IL12, IL15, IL18(-), IL21, IL27, TGFb, IFNa, IFNb, TGFb, LPS, dsRNA, Cp, Hp, Mt, Pf, Py, BCG, MgHV68, VLP, CD40, TCR/CD3/CD28, B7s, LFA3, TNF, Fas, TL1A, MHC, Ly49D, CD69, CD82, CD84, CD244, jagged-1, Notch, TSH, FLT3L, PF4, RON/MSP, KIR2DL4, hypoxia, ATP, A2A, Akt, Ly49, Txk, Tyk2, SOCS1, flu v, morphine, HIVp17 (activates Jak1/2, Stat1/5)
targets
Th1
Eph IL-14 (human)



1 Signal/Eph/TM
9



IL16 IL-16/LCF (human, mouse)
inhibit






15q26.3 GABPalpha, p300 TNFa, IL1, IL4, IFNa, caspase-3 IL-2, CtT, CsA/FK506, FceRI, BRCA1,
IL17




IL-17 (human, mouse)
activate
activate L ? cystine knot 1 2q31 NF-ATs
IL1, IL6, IL8, IL15, OX40, LPS, Sd, Hp, TRAF6, TLR4, IL23 IL1b, TNFa, IL23, GCSF, ICAM1, IkBa, RANTES, C3, FB, CD3&IL2
IL-17B/CX1/NERF (human, mouse)




cystine knot
5q32-34

TNFa, IL1b
IL-17C/CX2 (human)




cystine knot
16q24

TNFa, IL1b
IL-17D, IL27 (human)






13q12.11



IL-25, IL-17E(human)
activate


1 cystine knot
14q11.2

IL8, IL6, IL4, IL5, IL13, IFNa, TARC, Eotaxin, LIX EVI27/IL-17BR
IL-17F/ML-1(human)



1 cystine knot 1 6p12.1-21.1

IL8, GCSF, IL23, IL6, IFNg,
EPO Epo, erythropoietin(human, mouse, rat, cat, dog, bovine, sheep)
inhibit
activate
activate
1,2 EPO L 7q21 HIF1, HNF4, GATA1, GATA2, Sart-1,EAR3, NF-kB hypoxia, RA, TNFa, IL1, IL5, AgII, estrogen Bcl-xL, GATA-2, Hrk

Tpo, thrombopoietin, MKCSF, MGDF (human, mouse,rat, )
inhibit

activate 1 1 EPO
3q26.3-q27 E4TF1 estrogen, Subst.P, LPS


SF20/IL25=IL27(human, mouse)






19p13.3



M-CSF M-CSF, CSF1, MCSF (human)
mediate


op


1p21-p13
IL2, IL4, IL7, IL15, PMA, IGF1, UVB, LPS, TNF, RA, VLP
targets
leptin leptin, Ob (human)
induce/ inhibit


ob


7q31.3 PPARg, C/EBPa, HIF1, SREBP1 hypoxia, insulin, glucose
diabetes II
Somatotropin growth hormone, GH1 (human)
inhibit






17q24.2




prolactin, PRL (human)
induce/ inhibit






6p22.2-p21.3



HRF HRF, TPT1 (human, mouse, zebrafish,tabacco, yeast)






13q12-q14

IL2, IL13
tandem gene information:
human IL1 locus 2q13 [IL1a><IL1b,IL1F7>IL1F9>IL1F6>, <IL1F8, IL1F5> IL1F10> IL1RN>]
human IL10 locus 1q32.1 [IL10<IL19>IL20>IL24>]
human IL4 locus 5q25.3 [<IL5, (RAD50>), IL13>IL4]
human IFN locus 9p21.3 [b1<w1<a21<a4<A14<a7<a10<a5<a6<a13<a2<a8<a1]
 

IL/FGF/IFN/GH Receptors and Binding Factors.

(For impacts of each receptor on apoptosis , please see the top table.)
cat. protein name KO gene Structure 3D locus Binding partner upstream regulators memo
IL1R IL1R1, CD121a (human, mouse) L 1 IGx3/TM/TIR Ra 2q12 IL1apha, beta, ra shear stress, IL6, IL8, IL13, CD3/CD28/PMACSBG, c-Myc, ALK1, ALK5, MKK7, progesterone, androgen, D3, TGFb

IL1R2, CD121b (human)
1 IGx3/TM
2q12-q22 IL1 Hoxc8, AIRE, CD43, IL8, IL13, Dex, MDP, Ct, RA, D3, androgen,TGFb scavenging

LI1RAcP, IL1RAP (human,mouse,rat) 1 1 IGx3/TM/TIR
3q28
CD3/CD28, MDP, Hp, IL15

IL18R1, IL1Rrp(human,mouse) 1 1 IGx3/TM/TIR
2q12-22 IL-18, IL1zeta STAT3, HNF4a, IL2, IL15, IL21, Fas, C5a, TCR DC, NK

IL18BP (human, mosue)
1 IG
11q13 IL18, IL1zeta IRF1, C/EBPb, PPARg1, IFNg, IL12, IL18, GM-CSF, LPS, TRIF, SOCS1


ST2L, ST2, IL1RL1,Fit-1M (human, mouse)(rat)
1 IGx3/TM/TIR
19p13.2
AP-1, Raf, estrogen

IL18R2, IL18R.ac.p.l., IL18RAP (human, mouse)
1 IGx3/TM/TIR
2q12
IL-12, TGFb NK

oligophrenin-4/TIGIRR-2/IL1R8/IL1RAPL1(human)
1 IGx3/TM/TIR
Xp21.3

brain

TIGIRR-1/IL1R9/IL1RAPL2(human)
1 IGx3/TM/TIR
Xq22.2-q22.3


IL6R IL6R, CD126 (human)

IG/TM
1q21
ARNT2, Tprim, MDP, Ma, TIMP1 APCs

IL11Ra (human)

IG/TM
9p13
SCF, c-Myc, IL5, Hf, D3
T, heart
CR1-B IL3Ralpha, IL3RA, CD123(human)
1 CR1-B/TM
Xp22.3
LPS, b-glucan, Hi, IGF-1, PMA, IL5, IL13, NF-IL6, VLP DC
IL3R IL3/GM-CSF/IL5/Rbeta, CD131(human) 1 1 FN3 x2/TM
22q12.2-q13.1 IL3, IL5, GM-CSF PMA, TCDD, LPS, Sm APCs

IL2,4,7,9,15Rgamma, CD132, IL2RG  (human) L 1 FN3/TM
Xq13.1
IFNg, LPS, Hi, Ma, HCV,TCR/CD3/28, IL15, Fas, sIL6R, SCF, ribavirin B, T, NK, APCs

IL2/IL15 Rbeta, CD122 (human) L 1 FN3/TM
22q11.2-q13
Egr1,p53, Cdx2, Dex, CD3&IL2, PPARa T

IL4Ralpha, CD124 (human) L 1 FN3/TM/ITIM
16p11.2-12.1 IL4, SHP1 IL1b, IL2, IL4, IGF-1, IL10, TNFa, LPS, CSBG, Sp, HHV8, BCR, PMA, ALK1, IKKg, PTEN, STAT3, p73, D3
B

IL7Ralpha, CD127(human) L 1 FN3/TM
5p13 IL7 IL1, IL2, IL15, TNFa, CD40, GM-CSF, TCR/ CD3/CD28, Nur77, LPS, MDP, LTA/(-), Hf, Lm, Ma, BRCA1, Dex T

oncostatin M R, OSMR, OSMRB (human)

FN3x2/TM
5p13.2 OsM, IL31
AIRE, TRRAP, FSH

LIFR (human)

FN3/TM
5p13-p12 LIF, gp130 ARNT2, Hi


prolactin receptor, PRLR (human) 1
FN3x2/TM/?
5p14-p13 prolactin


growth hormone receptor, GHR (human)



5p13-p12 GH1


IL9R (human)
1 FN3/TM
Xq28 IL9 IL2,PMA, Hi, RA

IL12Rbeta 1 (human) L 1 FN3/TM
19p13.1
TCR, IL12, VLP


IL12Rbeta 2 (human) L
FN3/TM
1p31.3-p31.2
NF-ATc2, STAT3, t-Bet,IL15, IL21, IRF2, VLP


IL13Ralpha (human 1, 2) 1,2 1,2 FN3/TM
a(X), b(Xq24)
HNF4a,, IL1b/TNFa, IL27, IFNg, Gab2, LPS, progesterone APCs

EpoR(human) L 1 FN3/TM
19p13.3-p13.2
GATA-1, Sp1, IFNg, Fas, SCF, RAALK1, TGFR1 erythroid

c-MPL, TpoR (human) 1
FN3x2/TM
1p34
, Subst.P bm

GCSFR, CSF3R (human) 1
FN3x2/TM
1p35-p34.3
RANKL, IFNa bm

GM-CSF Ra, CSF2R, CD116, CSF2RA & CSF2RY (human)

FN3/TM
Xp22.32/ Yp11.3
GM-CSF, RANKL, LPS, Hp, PMA APCs

IL30R (formerly IL27Ra), WSX1, TCCR (human) L
FN3x3/TM
19p13.11 IL30


IL6ST, IL6Rbeta, gp130, CD130 (human) 1
FN3x2/TM 1 5q11 OsM, IL6, LIF, CNTF, vIL6, LIFR, Btk, Tec
Tc

IL31R, NR10, GLMR, GLM-R, GPL, CRL3 (human, mouse

CBDx2, FN3x2/TM
5q11.2 IL31



leptin receptor, LEPR, OBR (human) db
FN3x4/TM/?
1p31 leptin
bm
secreted CLF1, NR6, CRLF1 (human) 1
FN3x2
19p12

adipocyte
CNTFR CNTFRalpha, CNTFR (human) L
IG/FN3
9p13 CLF, CLC, CNTF TR3, TR4,RA
IL8 R, CCR see more CCRs







IL5Ra IL5Ralpha, CD125 (human) 1 1

3p26-p24
LPS, VLP, Subst.P
B
Sushi IL2Ralpha(list), CD25 1 1 2x Sushi(also in DAF, CR2)
10p15-p14
NF-kB, SRF, NRF2, TNFa, CD40, OX40, PMA, TCR/CD3/28, BCR, Notch, LPS, CpG, dsRNA, b-glucan, Ma, VapA, IL1, IL2, IL4, IL7, IL15, IL21, EphB6, CsA,Tax, THC, Dex, D3

IL15Ralpha(list) L 1 Sushi
10p15-p14
IL1, TCR/CD3/CD28, TNFa, IFNa,IFNg, LPS, Bm, Ld,Lm, Mt, Tg, Sp, cisplatin, TRIF
IL17R IL17R(human) 1
IL17R/TM
22q11.1
Ma, Fas, camptothecin APCs

Evi27/IL17BR/(IL17ER)(human)

IL17R/TM
3p21.1
IL4, IL10, IL13, Fc e RI


 
group name KO gene locus upstream regulators structure memo
IL-10R IL10Ralpha(human)
1 11q23.3 IFNa, IFNg, IL4, M-CSF, Fas, FSH, Hp, Tc, EV71, Stat4, androgen, camptothecin FN3x2/TM APCs, B, T, NK

IL10Rbeta/CRF2-4(human)
1 21q22.11 CD3/CD28, Tc FN3x2/TM IL-10, IL-26
IL-20R IL-20Ra (human)

6q23
FN3x2/TM IL20, IL-26
IL-22R IL22Ra1(human, soluble)

1 MVA FN3/TM pancreas
IL-23R IL23R (human)

1p32.1-p31.2
FN3/TM
IL28R IL28Ra, CRF2, 12 (human)

1p36.11


IFNR IFNabR1, AVP, IFNAR1(human, mouse) L
21q22.11 NF-kB, TNFa, Cp, Hp, Sp, SDF1, Tyr2, IKKs, YopP, PPARa, Blimp1, TIMP1 FN3x4/TM

IFNAR2 (human)


21q22.1
Hf


IFNgR1, CD119(human, mouse) 1
6q23-q24 IFNg, LPS, HBx, TNFa, IL13, flagellin, Hp, Lm, St, MVAPTH, PPARa FN3x2/TM APCs

IFNgR2/IFNGT1(human)

21q22.11 IFNg, TRAIL, IL1b, TNFa, Tprim, Subst.P, LPS, flagellin, Lm, SDF1,HBx, PTEN, TIMP1
FN3x2/TM APCs, B

On-line References

IL1R antagonist by Arend et al. (Annu. Rev. Immunol. 1998)
IL-10 by Pestka et al. (Annu Rev Immunol 2004), by Moore et al. (Annu. Rev. Immunol  2001)
IL-12 by Gately et al. (Annu. Rev. Immunol 1998)
IL-13 by Wynn (Annu Rev Immunol 2003)
IL-18 by Nakanishi et al. (Annu. Rev. Immunol  2001)
Interferon signaling by Katze et al. (Nat Rev Immunol 2002)


[Links]

Cytokines Online Pathfinder Encyclopaedia
The Cytokines Web
Cytokine Family Database (dbCFC)
Microarray analysis of Listeria-responsible genes including cytokines (Cohen et al. JBC 2000)

Copyright by Naohiro Inohara, Department of Pathology, University of of Michigan Medical School
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