Index Caspase CARD/DED/BIR Bcl-2  DD TNF/TNFR Kinases ILs Viral Lipid Engulf TF RING Toll Other Apop Other NFkB Alphabet

Death Domain (DD) containing proteins
group name apoptosis NF-kB activation interacting protein KO gene Locus Ligand 3D regulators
DD-receptor see Death Receptors of TNFR family

Mediator FADD (see DED proteins)

RAIDD (see CARD proteins)


TRADD (human, mouse, zebrafish) induce induce TNFRI, p75NTR, TRAF2,RIP,FADD, TRAF2, Stat1, keratin 8/18, HIPK2, Akt 1 1 16q22
N/TRAF2,N PTEN, CD3, UVC, PG-A2, heat shock, Hi, Ld, Lm, Mt, Tg, RA

unknown, 9130005N23Rik (mouse)

MYD88 & Tube  (see Innate Immunity)

PLAIDD, NRADD (rat, mouse) induce



Imd, BG5(D.m.) induce induce dFADD 1

kinase RIP, DAP kiasen, IRAK family (see kinases or Toll-associated)

other Ankyrin, Unc-44

Band 4.2, NaKATPase,GP85,Fodrin etc

Unc5(C.e.), human (a,b,c), Rcm(mouse), rat(h1, h2) induce
Netrins, NRAGE 1,2 1 4q21-q23

p53, KCl

ZUD (human, rat) enhance inhibit NF-kBs


p84N5(human, mouse, Dm, Ce, Ag, At, Dd), Sp) induce induce Rb
1 18p11.32

LRDD/Pidd(human,mouse) induce



MALT1 (see caspases & related proteins)


for NF-kB, click here

Incorrectly Reported MADD

Review of Death Recptors by Ashkenazi & Dixit (Science 1998)

Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. by Holler et al. (Nat Immunol 2000)

Copyright by Naohiro Inohara, Department of Pathology, University of of Michigan Medical School
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