Relevant Publications:

1. Braunstein, E.M., Qiao, T., Madison, B., Pinson, K. Dunbar, L., and Gumucio, D.L. Villin: a marker for development of the epithelial pyloric border. Dev. Dyn. 224:90-102, 2002.
2. Madison, B., Qiao, T., Braunstein, E., Dunbar, L., and Gumucio, D.L Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem. 277:33275-33283, 2002.
3. Rieder, G., Tessier, A.J., Qiao, X.T., Madison, B., Gumucio, D. and Merchant, J.L.: Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin. J Biol Chem, 280:4906-12, 2005.
4. Rieder, G., Tessier, A.J., Qiao, X.T., Madison, B., Gumucio, D. and Merchant, J.L.: Helicobacter-induced intestinal metaplasia in the stomach correlates with Elk-1 and serum response factor induction of villin. J. Biol. Chem., 280:4906-12, 2005.
5. Madison, B., Braunstein, K., Qiao, X., Kuizon, E., and Gumucio, D.: Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development 132:279-89, 2005.
6. Jones, R.G., Li, X., Gray, P.D., Kuang, J., Clayton, F., Samowitz, W.S., Madison, B.B., Gumucio, D.L. and Kuwada, S. K.: Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia and early postnatal lethality. In Press, J. Cell Biol. 2006.

This work is supported by:

NIH P01 DK062041 (PI – J. Merchant) Regulation of intestinal cell identity (7/1/02-6/30/07). Project #1 (PI-Gumucio)

NIH R01 DK065850. “Cell:cell interactions during intestinal development” (3/1/05-2/28/010).

NIH R21 CA124589 “A cellular key to the gastric inflammation-metaplasia-carcinoma sequence?” (1/1/07-12/31/08).

T32 HD007505 “Training Program in Organogenesis” (Pre-doctoral fellowship award to William Zacharias)

The University of Michigan Center for Computational Medicine and Biology, Pilot grant award.