Summary of our work
Download pdf summary of Hsp70 related work
Download pdf summary of Dynamics-related work
Download pdf summary of other
work
|
Binding of DnaJ (white) to Hsp70 in solution and in the crystal (orange) Ahmad A, Bhattacharya A, McDonald RA, Cordes M, Ellington
B, Bertelsen EB, Zuiderweg ER. Heat shock protein 70 kDa chaperone/DnaJ cochaperone
complex employs an unusual dynamic interface. Proc Natl Acad Sci U S A., 108; 18966-18971 (2011) |
|
Structures of Hsp70 proteins in solution (yellow and blue) vs crystal strucures (red and green) Bertelsen, E.B., Chang, L.,
Gestwicki, J.E. and Zuiderweg, E.R.P. ÒSolution conformation of E.coli Hsp70
complexed with ADP and substrateÓ.
Proc. Natl. Acad. Sci. 106, 8471-8476 (2009) Revington, M., Zhang, Yip, G.N.B., Kurochkin, A.V. and Zuiderweg, E.R.P. NMR investigations of allosteric processes in a two-domain Thermus Thermophilus Hsp70 molecular chaperone, J. Mol. Biol. 349, 163-183 (2005) |
|
|
ATP/ADP conformational change in Hsp70 in the crystal (left) and in solution (right) Bhattacharya, A., Kurochkin,
A.V., Yip, G.N.B., Zhang, Y., Bertelsen, E.B. and Zuiderweg. E.R.P. Allostery in the Hsp70 chaperones is
transduced by subdomain rotations. J. Mol. Biol. 388, 475-90, 2009 |
|
Binding site of the anti-cancer drug MKT-077 (cyan) to Hsp70 Rousaki A, Miyata Y, Jinwal UK, Dickey CA, Gestwicki JE,
Zuiderweg ER. Allosteric drugs: the interaction of antitumor compound
MKT-077 with human Hsp70 chaperones. J Mol Biol., 411, 614-632. (2011) |