TRPM5

General Information

Full gene name:transient receptor potential cation channel, subfamily M, member 5 Entrez Gene ID:29850 Location:11p15.5 Synonyms:LTRPC5, MTR1 Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs231362	247196	upstream

NCBI Summary

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]

OMIM

OMIM ID:`OMIM ID 604600 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• voltage-gated ion channel activity
• ion channel activity
• potassium channel activity
• calcium activated cation channel activity
• integral to membrane
• sodium channel activity
• plasma membrane

KEGG Pathways

• Taste transduction

GeneRIFs

• understanding the structural basis for TRPM5 function will ultimately allow the design of pharmaceuticals to enhance or interfere with taste sensations–{REVIEW} [PMID 17217064]
• common TRPM5 variants are likely to be associated with prediabetic phenotypes; and this may in turn contribute to the development of type 2 diabetes mellitus [PMID 21489577]
• regulation of TRPM5 by Ca2+ mediates sensory activation in the taste system [PMID 14657398]
• results suggest TRPM5 may play a role in upregulating endogenous expression of TRPA1, that TRPA1 activation may be an additional trigger for co-expressed calcium-dependent ion channels such as TRPM5, and that TRPM5 may amplify responses to TRPA1 ligands [PMID 21133676]
• TRPM5 gene is imprinted, with preferential expression from the paternal allele. [PMID 10607831]
• data show that extracellular acidification acts through specific residues on transient receptor potential cation channel, subfamily M(TRPM5) to block conduction through two distinct but related mechanisms [PMID 15731110]
• TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i [PMID 14634208]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 20660057]

PubMed Articles

Recent articles:

• Ketterer C et al. “Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes.” Metabolism. 2011 Sep;60(9):1325-33. PMID 21489577
• Buber MT et al. “Overexpression of human transient receptor potential M5 upregulates endogenous human transient receptor potential A1 in a stable HEK cell line.” Assay Drug Dev Technol. 2010 Dec;8(6):695-702. PMID 21133676
• Fushan AA et al. “Association between common variation in genes encoding sweet taste signaling components and human sucrose perception.” Chem Senses. 2010 Sep;35(7):579-92. PMID 20660057
• Hosgood HD 3rd et al. “Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.” Occup Environ Med. 2009 Dec;66(12):848-53. PMID 19773279
• Liman ER et al. “TRPM5 and taste transduction.” Handb Exp Pharmacol. 2007;(179):287-98. PMID 17217064
• Clapham DE et al. “International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.” Pharmacol Rev. 2005 Dec;57(4):427-50. PMID 16382100
• Liu D et al. “Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domains.” J Biol Chem. 2005 May 27;280(21):20691-9. PMID 15731110
• Prawitt D et al. “TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i.” Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15166-71. PMID 14634208
• Liu D et al. “Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5.” Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15160-5. PMID 14657398
• Strausberg RL et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. PMID 12477932

Top Pubmed articles linked to gene TRPM5 matching any search term:

• Glendinning JI et al. “The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice.” Physiol Behav. 2012 Aug 20;107(1):50-8. PMID 22683548
• Tóth B et al. “Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents.” Proc Natl Acad Sci U S A. 2012 Jul 30;. PMID 22847436
• Kyriazis GA et al. “Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion.” Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E524-32. PMID 22315413
• Ketterer C et al. “Genetic variation within the TRPM5 locus associates with prediabetic phenotypes in subjects at increased risk for type 2 diabetes.” Metabolism. 2011 Sep;60(9):1325-33. PMID 21489577
• Uchida K et al. “The role of thermosensitive TRP (transient receptor potential) channels in insulin secretion.” Endocr J. 2011;58(12):1021-8. PMID 21785227
• Colsoul B et al. “Transient receptor potential cation channels in pancreatic β cells.” Rev Physiol Biochem Pharmacol. 2011;161:87-110. PMID 21744203
• Guinamard R et al. “The non-selective monovalent cationic channels TRPM4 and TRPM5.” Adv Exp Med Biol. 2011;704:147-71. PMID 21290294
• Islam MS et al. “TRP channels of islets.” Adv Exp Med Biol. 2011;704:811-30. PMID 21290328
• Palmer RK et al. “Triphenylphosphine oxide is a potent and selective inhibitor of the transient receptor potential melastatin-5 ion channel.” Assay Drug Dev Technol. 2010 Dec;8(6):703-13. PMID 21158685
• Enklaar T et al. “Adding efficiency: the role of the CAN ion channels TRPM4 and TRPM5 in pancreatic islets.” Islets. 2010 Sep-Oct;2(5):337-8. PMID 21099334