SYN2

General Information

Full gene name:synapsin II Entrez Gene ID:6854 Location:3p25 Synonyms:SYNIIb, SYNII, SYNIIa Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs1801282	159593	downstream

NCBI Summary

This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. The TIMP4 gene is located within an intron of this gene and is transcribed in the opposite direction. Mutations in this gene may be associated with abnormal presynaptic function and schizophrenia. Alternative splicing of this gene results in two transcripts. [provided by RefSeq, Jul 2008]

OMIM

OMIM ID:`OMIM ID 600755 `_

NCBI Phenotypes

• Gene Reviews
• Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
• OMIM
• Schizophrenia
• GTR
• NHGRI GWA Catalog

Gene Ontology

• catalytic activity
• synaptic transmission
• ATP binding
• neurotransmitter secretion
• synaptic vesicle
• cell junction

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• A case-control study with synapsin II was conducted in 506 bipolar disorder patients and 507 healthy individuals from the Han Chinese population. No association was found in this study. [PMID 19665806]
• Affinity Capture-Western [PMID 11032911]
• Reconstituted Complex [PMID 11867766]
• Affinity Capture-Western [PMID 10358015]
• Two-hybrid [PMID 10358015]
• Two-hybrid [PMID 10358015]
• Two-hybrid [PMID 10358015]
• Affinity Capture-Western; Reconstituted Complex; Two-hybrid [PMID 10358015]
• Syn2 is likely to be involved in the etiology or pathogenesis of schizophrenia. [PMID 17766091]
• Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) [PMID 20628086]
• Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) [PMID 20379614]
• SYN2 rs3773364 A>G polymorphism is not a risk factor for susceptibility to epilepsy in this case-control study and meta-analysis. [PMID 21465568]
• This study suggests a positive association between synapsin II and schizophrenia, implying that synapsin II is involved in the etiology of schizophrenia. [PMID 15271586]
• Meta-analysis of gene-disease association. (HuGE Navigator) [PMID 17913586]
• Affinity Capture-Western [PMID 10820264]
• Observational study of gene-disease association. (HuGE Navigator) [PMID 19913121]
• Affinity Capture-MS [PMID 21906983]
• Results from our study indicate the involvement of SYN2 gene polymorphism in conferring risk to epilepsy; however, the genetic variant does not seem to modulate drug-response in epilepsy pharmacotherapy. [PMID 20034013]
• synapsin II variants are associated with susceptibility to schizophrenia. [PMID 15449241]

PubMed Articles

Recent articles:

• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Haerian BS et al. “Lack of association between synapsin II (SYN2) gene polymorphism and susceptibility epilepsy: a case-control study and meta-analysis.” Synapse. 2011 Oct;65(10):1073-9. PMID 21465568
• Bailey SD et al. “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.” Diabetes Care. 2010 Oct;33(10):2250-3. PMID 20628086
• Lakhan R et al. “Association of intronic polymorphism rs3773364 A>G in synapsin-2 gene with idiopathic epilepsy.” Synapse. 2010 May;64(5):403-8. PMID 20034013
• Rose JE et al. “Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.” Mol Med. 2010 Jul-Aug;16(7-8):247-53. PMID 20379614
• Talmud PJ et al. “Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.” Am J Hum Genet. 2009 Nov;85(5):628-42. PMID 19913121
• Wang Y et al. “No association between bipolar disorder and syngr1 or synapsin II polymorphisms in the Han Chinese population.” Psychiatry Res. 2009 Sep 30;169(2):167-8. PMID 19665806
• Zeggini E et al. “Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.” Nat Genet. 2008 May;40(5):638-45. PMID 18372903
• Saviouk V et al. “Association of synapsin 2 with schizophrenia in families of Northern European ancestry.” Schizophr Res. 2007 Nov;96(1-3):100-11. PMID 17766091
• Cavalleri GL et al. “Multicentre search for genetic susceptibility loci in sporadic epilepsy syndrome and seizure types: a case-control study.” Lancet Neurol. 2007 Nov;6(11):970-80. PMID 17913586

Top Pubmed articles linked to gene SYN2 matching any search term:

• Sharma NK et al. “Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects.” J Clin Endocrinol Metab. 2011 Feb;96(2):E394-403. PMID 21084393
• Bailey SD et al. “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.” Diabetes Care. 2010 Oct;33(10):2250-3. PMID 20628086
• Zeggini E et al. “Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.” Nat Genet. 2008 May;40(5):638-45. PMID 18372903