SSR4

General Information

Full gene name:signal sequence receptor, delta Entrez Gene ID:6748 Location:Xq28 Synonyms:TRAPD Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs3020789	166643	upstream

NCBI Summary

This gene encodes the delta subunit of the translocon-associated protein complex which is involved in translocating proteins across the endoplasmic reticulum membrane. The encoded protein is located in the Xq28 region and is arranged in a compact head-to-head manner with the isocitrate dehydrogenase 3 (NAD+) gamma gene and both genes are driven by a CpG-embedded bidirectional promoter. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2011]

OMIM

OMIM ID:`OMIM ID 300090 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• calcium ion binding
• cellular protein metabolic process
• Sec61 translocon complex
• SRP-dependent cotranslational protein targeting to membrane
• integral to membrane
• translation
• intracellular protein transport
• gene expression

KEGG Pathways

• Protein processing in endoplasmic reticulum

GeneRIFs

• Affinity Capture-MS [PMID 17314511]
• results of this study implicate TRAPD as a candidate gene with potential functions that might be associated with ultraviolet-induced melanomagenesis and metastasis [PMID 15057039]
• Affinity Capture-MS [PMID 17353931]
• Affinity Capture-MS [PMID 17353931]
• Affinity Capture-MS [PMID 17353931]
• Affinity Capture-MS [PMID 17353931]
• Affinity Capture-MS [PMID 17342744]
• Affinity Capture-Western [PMID 14684739]
• Affinity Capture-Western [PMID 14684739]
• Affinity Capture-MS [PMID 21987572]

PubMed Articles

Recent articles:

• Lee KA et al. “Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.” J Biol Chem. 2011 Dec 2;286(48):41530-8. PMID 21987572
• Kim W et al. “Systematic and quantitative assessment of the ubiquitin-modified proteome.” Mol Cell. 2011 Oct 21;44(2):325-40. PMID 21906983
• Wagner SA et al. “A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.” Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. PMID 21890473
• Shi Y et al. “A data set of human endogenous protein ubiquitination sites.” Mol Cell Proteomics. 2011 May;10(5):M110.002089. PMID 20972266
• Danielsen JM et al. “Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.” Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. PMID 21139048
• Xu G et al. “Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.” Nat Biotechnol. 2010 Aug;28(8):868-73. PMID 20639865
• Meierhofer D et al. “Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry.” J Proteome Res. 2008 Oct;7(10):4566-76. PMID 18781797
• Dall’Era MA et al. “HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells.” Prostate. 2007 May 15;67(7):714-21. PMID 17342744
• Ewing RM et al. “Large-scale mapping of human protein-protein interactions by mass spectrometry.” Mol Syst Biol. 2007;3:89. PMID 17353931
• Koch HB et al. “Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.” Cell Cycle. 2007 Jan 15;6(2):205-17. PMID 17314511

Top Pubmed articles linked to gene SSR4 matching any search term:

• Dodson G et al. “The role of assembly in insulin’s biosynthesis.” Curr Opin Struct Biol. 1998 Apr;8(2):189-94. PMID 9631292