REG4

General Information

Full gene name:regenerating islet-derived family, member 4 Entrez Gene ID:83998 Location:1p13.1-p12 Synonyms:GISP, RELP, REG-IV Type:protein-coding

User SNPs

SNPs given by the user that are near or inside this gene:

SNP	Distance (bp)	Direction
rs10923931	163756	upstream

NCBI Summary

None available.

OMIM

OMIM ID:`OMIM ID 609846 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• extracellular region
• carbohydrate binding

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• Overexpression of REGIV mRNA is assessed with peritoneal recurrence in gastric adenocarcinoma. [PMID 21780125]
• REG4 may play an important role in the development and progression of colorectal cancer, as well as in intestinal morphogenesis and epithelium restitution [PMID 20126989]
• Increased expression of Reg IV is associated wirh hormone refractory metastatic prostate cancer [PMID 15788672]
• The solution structure of hRegIV-P91S was determined, showing that it adopts a typical fold of C-type lectin. Based on the chemical shift perturbations of amide resonances, two calcium-independent mannan-binding sites were proposed [PMID 20692269]
• Reg IV expression experienced up-regulation in gastric intestinal metaplasia and adenoma and then down-regulation with malignant transformation of gastric epithelial cells. [PMID 19740514]
• Reg IV staining can aid in diagnosis of gastrointestinal signet ring cell carcinoma. [PMID 18580680]
• REG4 is expressed in pancreatic cancer, and serum levels of REG4 offer a useful indicator for distinguishing between patients with pancreatic cancer and healthy subjects [PMID 19789838]
• REG4 may be a prognostic indicator and a better serum marker than carcinoembryonic antigen and carbohydrate antigen 19-9 for early diagnosis of gastric cancer. [PMID 21419474]
• Reg IV is a potent activator of the EGF receptor/Akt/AP-1 signaling pathway in colorectal carcinoma [PMID 16401477]
• Reg IV might accelerate cell growth and disease progression of adenoid cystic carcinomas . [PMID 19076683]
• RegIV expression was markedly higher in gastric cancer patients with peritoneal metastases compared to those without; level of RegIV mRNA in gastric cancer patients was related to the extent of wall penetration [PMID 18505053]
• Reg IV might accelerate peritoneal metastasis in gastric cancer. Reg IV in lavage fluids might be a good marker for peritoneal metastasis [PMID 19143768]
• Data demonstrated in vitro and in vivo that REG4 protein overexpression was associated with an unfavorable response to preoperative chemoradiotherapy. [PMID 19546835]
• Knockdown of Reg IV impacted the ability of insulin and EGF to stimulate downstream tyrosine phosphorylation. [PMID 21445968]
• Local Reg IV expression may be influenced by the growth factors basic fibroblast growth factor and somatotropin and dtheri receptors [PMID 19924642]
• reg4 is amplified in the early stages of pancreatic cancer development [PMID 19834624]
• RELP serves as a marker for appendiceal mucinous cystadenomas and pseudomyxoma peritonei and may contribute to the pathogenesis of these disorders. [PMID 16323007]
• overexpression of Reg IV may be an early event in colorectal carcinogenesis. [PMID 14550954]
• RegIV is expressed in the gastrointestinal tract and in digestive tract neuroendocrine tumor [PMID 20349522]
• RegIV enhances LoVo cell migration and invasion, and its CRD domain is critical for these effects. [PMID 20417867]
• REG IV overexpression may be an early event in colorectal carcinoma carcinogenesis. [PMID 20183800]
• Reg IV as an important modulator of gastrointestinal cell susceptibility to irradiation; hence, it is a potential target for adjunctive treatments for human colorectal cancer and other gastrointestinal malignancies. [PMID 19900450]
• These results suggest that Reg IV expression is an independent prognostic indicator of relapse after radical prostatectomy. [PMID 18754868]
• REG4, BIRC5 and NEIL2 genes might have a role in the sensitivity of cancer patients to radiotherapy [PMID 22199273]
• Reg IV is involved in gallbladder carcinoma carcinogenesis through intestinal metaplasia and is associated with relatively favorable prognosis in patients after surgery [PMID 19716164]
• Overexpression of REG4 is associated with pancreatic cancer [PMID 16918991]
• among major urologic cancers, Reg IV is expressed frequently in prostate cancer, and that serum Reg IV represents a novel biomarker for prostate cancer [PMID 19082448]
• Expression of REG Ialpha but not REG IV was an independent predictor of poor outcome in patients with gastric cancer. [PMID 19329938]
• serum Reg IV concentration may predict metastatic recurrence of colorectal cancer in the liver.Reg IV protein expression induced by growth factors may function as a growth-promoting and/or an antiapoptotic factor in the peritumoral mucosa of CRC. [PMID 18187959]
• Results suggest that RELP might be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. [PMID 12819006]
• REG4 is involved in the ‘intestinal’ pathway of carcinogenesis in intraductal papillary mucinous neoplasms of the pancreas [PMID 19136934]
• GLI1 promotes RegIV transcription by binding to the RegIV gene promoter in pancreatic cancer. [PMID 21494603]

PubMed Articles

Recent articles:

• Vanderlaag K et al. “Regenerating islet-derived family member, 4 modulates multiple receptor tyrosine kinases and mediators of drug resistance in cancer.” Int J Cancer. 2012 Mar 15;130(6):1251-63. PMID 21445968
• Moon JH et al. “REGIV as a potential biomarker for peritoneal dissemination in gastric adenocarcinoma.” J Surg Oncol. 2012 Feb;105(2):189-94. PMID 21780125
• Kobunai T et al. “REG4, NEIL2, and BIRC5 gene expression correlates with gamma-radiation sensitivity in patients with rectal cancer receiving radiotherapy.” Anticancer Res. 2011 Dec;31(12):4147-53. PMID 22199273
• Tao HQ et al. “Evaluation of REG4 for early diagnosis and prognosis of gastric cancer.” Hum Pathol. 2011 Oct;42(10):1401-9. PMID 21419474
• Wang F et al. “Identification of RegIV as a novel GLI1 target gene in human pancreatic cancer.” PLoS One. 2011 Apr 11;6(4):e18434. PMID 21494603
• Ho MR et al. “Human RegIV protein adopts a typical C-type lectin fold but binds mannan with two calcium-independent sites.” J Mol Biol. 2010 Oct 1;402(4):682-95. PMID 20692269
• Guo Y et al. “RegIV potentiates colorectal carcinoma cell migration and invasion via its CRD domain.” Cancer Genet Cytogenet. 2010 May;199(1):38-44. PMID 20417867
• Li FY et al. “RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor.” J Zhejiang Univ Sci B. 2010 Apr;11(4):258-66. PMID 20349522
• Li XH et al. “REG IV overexpression in an early stage of colorectal carcinogenesis: an immunohistochemical study.” Histol Histopathol. 2010 Apr;25(4):473-84. PMID 20183800
• Rafa L et al. “REG4 acts as a mitogenic, motility and pro-invasive factor for colon cancer cells.” Int J Oncol. 2010 Mar;36(3):689-98. PMID 20126989

Top Pubmed articles linked to gene REG4 matching any search term:

• Vanderlaag K et al. “Regenerating islet-derived family member, 4 modulates multiple receptor tyrosine kinases and mediators of drug resistance in cancer.” Int J Cancer. 2012 Mar 15;130(6):1251-63. PMID 21445968
• Iglesias-García J et al. “[Pancreatic tumors].” Gastroenterol Hepatol. 2008 Oct;31 Suppl 4:83-92. PMID 19434873
• Oue N et al. “Expression and localization of Reg IV in human neoplastic and non-neoplastic tissues: Reg IV expression is associated with intestinal and neuroendocrine differentiation in gastric adenocarcinoma.” J Pathol. 2005 Oct;207(2):185-98. PMID 16086444
• Zhang YW et al. “Reg gene family and human diseases.” World J Gastroenterol. 2003 Dec;9(12):2635-41. PMID 14669303