MIR139
SNPs given by the user that are near or inside this gene:
| SNP |
Distance (bp) |
Direction |
|---|
| rs1552224 |
106924 |
upstream |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
No OMIM data available for this gene.
No phenotypes found linked to this gene.
No GO terms found linked to this gene.
No pathways found linked to this gene.
- Observational study of gene-disease association. (HuGE Navigator) [PMID 20889907]
- miR-139-3p, pmiR-675, and miR-335 allowed separation of adrenocortical adenomas from adrenocortical carcinomas [PMID 21471143]
- Expression of miR-139 is reduced in human metastatic hepatocellular carcinoma samples and correlates with prognosis. The microRNA miR-139 interacts with ROCK2 and reduces its expression in hepatocellular carcinoma. [PMID 20951699]
- HER2 interaction with CD44 up-regulates CXCR4 by inhibiting expression of miR-139, at the epigenetic level, in gastric cancer cells. [PMID 21925125]
Recent articles:
- Bao W et al. “HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric cancer cells.” Gastroenterology. 2011 Dec;141(6):2076-2087.e6. PMID 21925125
- Schmitz KJ et al. “Differential expression of microRNA-675, microRNA-139-3p and microRNA-335 in benign and malignant adrenocortical tumours.” J Clin Pathol. 2011 Jun;64(6):529-35. PMID 21471143
- Hu Z et al. “Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival.” Am J Respir Crit Care Med. 2011 Mar 1;183(5):641-8. PMID 20889907
- Wong CC et al. “The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2.” Gastroenterology. 2011 Jan;140(1):322-31. PMID 20951699
- Shen J et al. “Novel genetic variants in miR-191 gene and familial ovarian cancer.” BMC Cancer. 2010 Feb 18;10:47. PMID 20167074
- Landgraf P et al. “A mammalian microRNA expression atlas based on small RNA library sequencing.” Cell. 2007 Jun 29;129(7):1401-14. PMID 17604727
- Griffiths-Jones S et al. “miRBase: microRNA sequences, targets and gene nomenclature.” Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4. PMID 16381832
- Lagos-Quintana M et al. “Identification of tissue-specific microRNAs from mouse.” Curr Biol. 2002 Apr 30;12(9):735-9. PMID 12007417