IL34

General Information

Full gene name:interleukin 34 Entrez Gene ID:146433 Location:16q22.1 Synonyms:IL-34, C16orf77 Type:protein-coding

eQTLs

This gene is a target of the following eQTL associations:

eQTL	Gene	Tissue	Population	Organism	P-value	Source
rs7957197	C16orf77	LCL	YRI	Homo sapiens	3e-06	SCAN

NCBI Summary

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

OMIM

OMIM ID:`OMIM ID 612081 `_

NCBI Phenotypes

No phenotypes found linked to this gene.

Gene Ontology

• innate immune response
• extracellular space
• inflammatory response
• cytokine activity
• positive regulation of protein phosphorylation
• positive regulation of cell proliferation
• macrophage colony-stimulating factor receptor binding
• growth factor activity

KEGG Pathways

No pathways found linked to this gene.

GeneRIFs

• study identifies IL-34 expression in the synovial tissue of patients with arthritis; this cytokine, as a downstream effector of TNFalpha and IL-1beta, may contribute to inflammation and bone erosions in rheumatoid arthritis [PMID 22039170]
• The different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues. [PMID 20504948]
• Discovered IL-34 and its receptor CSF1 by functional screening of the extracellular proteome. [PMID 18467591]

PubMed Articles

Recent articles:

• Chemel M et al. “Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients.” Ann Rheum Dis. 2012 Jan;71(1):150-4. PMID 22039170
• Wei S et al. “Functional overlap but differential expression of CSF-1 and IL-34 in their CSF-1 receptor-mediated regulation of myeloid cells.” J Leukoc Biol. 2010 Sep;88(3):495-505. PMID 20504948
• Lin H et al. “Discovery of a cytokine and its receptor by functional screening of the extracellular proteome.” Science. 2008 May 9;320(5877):807-11. PMID 18467591
• Lim J et al. “A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.” Cell. 2006 May 19;125(4):801-14. PMID 16713569
• Strausberg RL et al. “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.” Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. PMID 12477932

Top Pubmed articles linked to gene IL34 matching any search term:

• Below JE et al. “Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.” Diabetologia. 2011 Aug;54(8):2047-55. PMID 21647700