|YANG RESEARCH GROUP MEMBERS - Hee Sun Chung|
Hee Sun Chung
Phone: (734) 647-9708
Inorganic Chemistry, University of Oklahoma, 1997
Despite its effectiveness, the use of ASNase is not without problems. Due to its bacterial origin, namely E. coli and Erwinia carotovora, ASNase causes immunogenic response in patients and requires administration in hospital setting. The problem is compounded by the fact that ASNase has short half-life which in turn necessitates frequent injection.
In order to overcome the problems of short plasma-half life and immunogenicity of L-ASNase, we plan to encapsulate the enzyme into red blood cells (RBC). Encapsulation into RBCs can help ASNase dodge the detection of the host immune system and at the same time protect the enzyme from proteolytic degradation, thereby increasing half-life.
Upjohn Fellowship in Pharmaceutical Sciences
''Synthesis and Characterization of Osmium Nitrosyl Porphyrins Containing Organo, Halogeno and mu-Oxo Ligands, and Extensions to the First Organometallic Thionitrosyl Porphyrins.'' Cheng, L.; Chen, L.; Chung, H.-S.; Khan, M. A.; Richter-Addo, G. B.; Young, V. G., Jr. Organometallics, 1998, 17(18), 3853-3864.
Hee Sun Chung, Young Min Kwon, Victor C. Yang*, ''Protein Transduction Domain Mediated Uptake of L-Asparaginase into Red Blood Cells'', 2006 AAPS Annual Meeting and Exposition, San Antonio, TX, Oct. 31, 2006.
Although Hee Sun currently calls Seattle home where her family is, she also enjoys life in Ann Arbor where fireflies abound in summer and snow in winter time. When not in lab, she can be found at an unspecified location on Franklin St. Some day she would like to learn to sail and travel to northeast to see fall foliage.