get.mtc.r = R code that will identify the optimal combination for the next patient to be enrolled based upon the data collected on enrolled patients run.onesim.r = R code that will run one simulated trial jags model.txt = text file containing hierarchical model description in WinBUGS syntax Actual Trial.r = R code to find dose combination to assign to fourth subject in a hypothetical trial Simulation Study.r = sample R code to run a simulation study comprised of 1000 simulations The MCMC calculations in both run.onesim.r and get.mtc.r are facilitated with the R library rjags, which can be downloaded at http://cran.r-project.org/web/packages/rjags/index.html.