runsim.r = R code that will run one simulated trial for a 5x5 combination trial; for a different RxC number of combinations, some editing is required in sections "Make matrix of true DLT rates for each combination" & "Assign prior means and variances to each parameter" subroutines.r = additional R code that is loaded by runsim.r jags model.txt = text file containing WinBUGS syntax for Bayesian modeling of 5x5 combination trial; for a different RxC number of combinations, the number of d variables (d1, d2, ....) must be edited, along with the dimension of alpha The MCMC calculations in runsim.r are facilitated with the R library rjags, which can be downloaded at http://cran.r-project.org/web/packages/rjags/index.html.