High-Speed Air-Liquid Two-Phase Flow Systems for Cytometry

Develop disposable fluorescence-activated cell sorters (FACS) that uses high-speed air-liquid two-phase microfluidics systems to produce a focused high-speed stream of cells, and electrowetting-assisted non-linear flow pattern changes to perform high-speed cell sorting.
Biomed. Microdev
. 2002,4, 141-149; J. Am. Chem. Soc. 2003, 125, 14678-14679.

Featured in: Michigan Engineering Magazine

 


Towards an Animal-on-a-Chip/Mini-Human

Biomimetic microfluidic circulatory support systems. 

 Lab Chip 2003, 3, 318-323; Adv. Mater. 2004, 16, 1320-1323; Analyst 2004,129, 1026-1031; PNAS 2004, 101, 15861-15866; Anal Chem 2005, 77, 3993-3999.

Featured in: Scientific American, Nature, Science News, MIT Technology Review, Undergraduate Winner at Collegiate Inventors Competition, ….

spermsorter 


Microfluidics for Assisted Reproductive Technologies

An integrated microfluidic device to sort motile sperm from non-motile ones.
Anal. Chem. 2003, 75, 1671-1675; Reproduc. Biomed. Online. 2003, 7, 75-81;

Hum. Reprod. Update 2003, 9, 451-461.

Featured in: Nature Materials, Nature Science Update, Small Time Magazine, Science News, Whitaker Foundation News, WNBC channel 4, ....

 


Subcellular Signaling Studies

Use of PARTCELL to study subcellular EGF signaling.  
Nature, 2001, 411, 1016;  Dev. Cell, 2002, 3, 245-257; Chem. Biol., 2003, 10, 123-130

Featured in: J. Cell Biol, Chemical & Engineering News, Lab Chip, Associated Cell Graphics, New York Times Science Times, Mol. Cell, ...

 microenvironomics


 Microenvironomics

Systematic study of how micro- and nanoscale environments affect cell function.
Curr. Top. Med. Chem. 2003, 3, 687-703.

 

 Nanotechnology

 

Cracking fabrication of reconfigurable protein matrices and nanostructures.
Nat. Mater. 2005, 4, 403-406.