Method: Orthodontic patients are currently being recruiting and classified into two research groups (~80/group): hypodontia patients and controls. DNA is being collected from patient saliva along with information outlining cancer and dental family histories. RUNX2 SNPs (rs545289, rs1406846, and rs6930053) will be genotyped using Taqman®-based methodology. A Chi-square analysis will be used to access Hardy-Weinberg equilibrium in the control population and to test for association of each SNP with the two groups (significance at p<0.05).
Result: DNA has been collected from 9 patients with hypodontia and 15 controls. Within this population, hypodontia of maxillary lateral incisors is observed most frequently followed by mandibular 2nd molars, maxillary 1st premolars and maxillary 2nd premolars. Two hypodontia patients also exhibited one or more pegged-shaped lateral incisors.
Conclusion: The teeth affected by hypodontia in this population are consistent with those previously reported at UK. Statistical conclusions will be summarized following completion of genotyping.
Keywords: Genetics and hypodontia