Objective: To compare the bone-crest change in a group of patients with elevated Dpd/CrU, versus a control group with normal DpdU/CrU, after the placement of upper maxillary dental implants.
Method: After being granted IRB approval, 20 controls with normal DpdU/CrU (2.3-5.4 females; 3.0-7.4 males) and 20 patients with high DpdU/CrU were enrolled from all individuals undergoing placement of upper maxillary dental implants, at the Center for Dental Studies and Research in Bogotá, Colombia. The DpdU/CrU ratio was measured, using a solid-phase chemo-luminescent immunoassay technique. The height of the bone crest was radiographically measured at baseline and two months after the implant procedure.
Distributional and homocedastic assumptions were tested with Shapiro-Wilk’s and Fisher’s test, respectively. Mean differences for continuous variables were tested with Student’s T test. In all cases α=0.05.
Results: The mean loss of bone-crest height was statistically larger (p=6.0x10-4) in patients with high DpdU/CrU (0.402mm), versus controls with normal DpdU/CrU (0.013mm).
Conclusions: Due to the statistically significant difference in bone-crest change between patients with a high DpdU/CrU ratio versus controls with a normal DpdU/CrU ratio, this study adds evidence to support the potential usefulness of this measurement to predict the degree of bone-reabsoprtion after the placement of dental implants. Further confirmatory studies are needed to confirm and expand these findings, including more stringent clinical endpoints.
Keywords: Bone, Demineralization, Molecular biology and Oral implantology
See more of: Implantology Research