Method: In the present study, we aimed to fine map 14q24.3 in an expanded population data set of 72 families from the Philippines. This locus had suggestive linkage results (recessive single-point LOD score of 2.06) with high caries susceptibility on the studied population. We selected 97 single nucleotide polymorphism markers spanning the candidate region. Those markers were chosen based on allele frequencies, gene structure, and patterns of linkage disequilibrium and haplotype blocks. Genotypes are in Hardy-Weinberg equilibrium. Family-Based Association test (FBAT) was used to determine the presence of possible overtransmission of alleles under a recessive model. P-values lower than 0.05 are considered statistically significant.
Result: The results suggest that seven markers in ESRRB (estrogen-related receptor beta; rs745011, p=0.0003; rs1077430, p=0.03; rs2860216, p=0.0001; rs4903399, p=0.001; rs4903419, p=0.003; rs6574293, p=0.005; and rs10132091, p= 0.005) at 14q24.3 are associated with high caries experience.
These results suggest that we identified a new candidate gene for caries, which is likely involved in the development of salivary glands, specifically the parotid gland.
Keywords: Caries, Cariology and Genetics
See more of: Cariology Research - Detection, Risk Assessment and Others