Method: Intermittent PTH (80μg/kg) or vehicle was injected to young mice (6-7 weeks old male C57BL/6) once a day for fourteen days. Gene expression of chondrocyte maturation markers, proliferation, condylar cartilage thickness and micro-CT analysis was evaluated in the mandibular condyle from both treatment groups.
Result: In young growing mice, intermittent PTH therapy caused a significant increase in the mandibular condylar cartilage thickness and VEGF expression compared to vehicle treated controls. Further PTH treatment caused a significant decrease in OPG expression. And in the subchondral bone, PTH treatment caused a significant decrease in bone volume compared to vehicle treated group.
Conclusion: Intermittent PTH treatment (80μg/kg/day) caused increased condylar cartilage thickness but a decrease in mandibular condylar bone density in young growing mice.
Keywords: Oral biology, TMJ and masticatory muscles and Temporomandibular joint