Methods: Edentate patients with (n=46) or without (n=36) type 2 diabetes undergoing surgical placement of 2 mandibular implants were assessed for healing complications 1 week post-operatively. Clinical assessments of complications were made of healing by a single masked examiner, and of inflammation by 3 independent examiners using standardized photographs. Clinical evaluations were based on a 4-point scale (0=none; 1=mild; 2=moderate; 3=severe) for erythema, edema, exudate, flap closure, infection and hematoma. Pain was rated using a visual analog scale (VAS) and self-reported days of pain. Assessment of the severity of post-operative healing complications and inflammation were comparatively assessed based on diabetes status and on levels of glycemic control at baseline (HbA1c ranged from 5.2% to 9.8%).
Results: All mean scores for clinical complications were <1 (mild), mean days of pain were 3.5, and VAS_pain was 35.2 out of 100. Mean complication scores (p=0.775), mean inflammation scores (p=0.786), VAS_pain (p=0.14), and days of pain (p=0.94) taken 1 week following implant surgery were not significantly correlated with either diabetes status or level of glycemic control. No patients had significant clinical complications requiring additional therapy at the 1 week post-operative visit.
Conclusions: This study failed to identify a relationship between diabetes status and glycemic control with post-operative complications, suggesting that patients with type 2 diabetes within this range of glycemic control may not be as susceptible to compromised oral wound healing as thought. Study supported by NIDCR (DE018902).
Keywords: Diabetes, Epithelium/epithelial, Human, Implants and Wound healing