Methods: A total of eighty (80) qualified subjects were enrolled on baseline visit, they were randomized into one of 2 treatments, all eighty subjects completed the research and were evaluable at all visits. Test products included a stannous containing fluoride dentifrice (experimental dentifrice) and a negative control dentifrice (Colgate® Super value). At Baseline, Efficacy assessments including tactile (Yeaple probe score) and thermal (Schiff air index and VAS Scale on thermal stimuli) measurements were conducted. Subjects were randomly assigned to one of two treatments and used the product twice daily for 3 days following the manufacture usage instruction. Thermal examination (Schiff air index and VAS Scale) was conducted after the 1st time product usage, tactile and thermal measurements were conducted at Day 3. Analysis of covariance was used to analyze data. All comparisons were two-sided with a significance level of 0.05.
Results: After only once product usage, the stannous containing fluoride dentifrice group showed significant lower Thermal Schiff Air acore and VAS score relative to negative control with p value 0.0025, 0.0124, respectively. After 3 days product usage, the stannous containing fluoride dentifrice group showed significant lower Thermal Schiff Air acore and VAS score relative to negative control, significant higher yeaple probe score relative to the negative control, all p values <0.001.
Conclusions: The study demonstrated the instant and rapid sensitivity relief efficacy of the stannous containing sodium fluoride dentifrice.
Keywords: Clinical trials and Dentifrices