Publications

1: Barmada SJ, Ju S, Arjun A, Batarse A, Archbold HC, Peisach D, Li X, Zhang Y, Tank EMH, Qiu H, Huang EJ, Ringe D, Petsko G, Finkbeiner S. Amelioration of toxicity in neuronal models of amyotrophic lateral sclerosis by hUPF1. Proc Natl Acad Sci U S A. 2015 Jun 8. pii: 201509744. [Epub ahead of print] PMID: 26056265

2: Barmada SJ. Linking RNA dysregulation and neurodegeneration in amyotrophic lateral sclerosis. Neurotherapeutics. 2015 Feb 18. PMID: 25689976

3: Barmada SJ, Serio A, Arjun A, Bilican B, Daub A, Ando DM, Tsvetkov A, Pleiss M, Li X, Peisach D, Shaw C, Chandran S, Finkbeiner S. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models. Nat Chem Biol. 2014 Aug;10(8):677-85. doi: 10.1038/nchembio.1563. Epub 2014 Jun 29. PubMed PMID: 24974230.

4: Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, Roberson ED, Tourtellotte WG, Chen B, Tsai LH, Huang EJ. ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. J Clin Invest. 2014 Mar 3;124(3):981-99. doi: 10.1172/JCI72723. Epub 2014 Feb 10. PubMed PMID: 24509083; PubMed Central PMCID: PMC3938263.

5: Tsvetkov AS, Arrasate M, Barmada S, Ando DM, Sharma P, Shaby BA, Finkbeiner S. Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration. Nat Chem Biol. 2013 Sep;9(9):586-92. doi: 10.1038/nchembio.1308. Epub 2013 Jul 21. PubMed PMID: 23873212; PubMed Central PMCID: PMC3900497.

6: Serio A, Bilican B, Barmada SJ, Ando DM, Zhao C, Siller R, Burr K, Haghi G, Story D, Nishimura AL, Carrasco MA, Phatnani HP, Shum C, Wilmut I, Maniatis T, Shaw CE, Finkbeiner S, Chandran S. Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4697-702. doi: 10.1073/pnas.1300398110. Epub 2013 Feb 11. PubMed PMID: 23401527; PubMed Central PMCID: PMC3607024.

7: Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV Jr, Gitler AD. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nat Genet. 2012 Dec;44(12):1302-9. doi: 10.1038/ng.2434. Epub 2012 Oct 28. PubMed PMID: 23104007; PubMed Central PMCID: PMC3510335.

8: Martens LH, Zhang J, Barmada SJ, Zhou P, Kamiya S, Sun B, Min SW, Gan L, Finkbeiner S, Huang EJ, Farese RV Jr. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury. J Clin Invest. 2012 Nov 1;122(11):3955-9. doi: 10.1172/JCI63113. Epub 2012 Oct 8. PubMed PMID: 23041626; PubMed Central PMCID: PMC3484443.

9: Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, Wilmut I, Finkbeiner S, Maniatis T, Shaw CE, Chandran S. Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5803-8. doi: 10.1073/pnas.1202922109. Epub 2012 Mar 26. PubMed PMID: 22451909; PubMed Central PMCID: PMC3326463.

10: Barmada SJ, Finkbeiner S. Pathogenic TARDBP mutations in amyotrophic lateral sclerosis and frontotemporal dementia: disease-associated pathways. Rev Neurosci. 2010;21(4):251-72. Review. PubMed PMID: 21086759.

11: Barmada SJ, Skibinski G, Korb E, Rao EJ, Wu JY, Finkbeiner S. Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis. J Neurosci. 2010 Jan 13;30(2):639-49. doi: 10.1523/JNEUROSCI.4988-09.2010. PubMed PMID: 20071528; PubMed Central PMCID: PMC2821110.

12: Waung MW, Grossman AW, Barmada SJ, Josephson SA, Dillon WP, Ralph JW. Pearls & oy-sters: the use of CT venography in Hirayama disease. Neurology. 2012 Jul 31;79(5):e38-40. doi: 10.1212/WNL.0b013e3182616fe8. PubMed PMID: 22851722; PubMed Central PMCID: PMC3405252.

13: Barmada S, Finkbeiner S. Bringing SOD1 into the fold. Nat Neurosci. 2010 Nov;13(11):1303-4. doi: 10.1038/nn1110-1303. PubMed PMID: 20975748.

14: Jeffrey M, Goodsir C, McGovern G, Barmada SJ, Medrano AZ, Harris DA. Prion protein with an insertional mutation accumulates on axonal and dendritic plasmalemma and is associated with distinctive ultrastructural changes. Am J Pathol. 2009 Sep;175(3):1208-17. doi: 10.2353/ajpath.2009.090125. Epub 2009 Aug 21. PubMed PMID: 19700753; PubMed Central PMCID: PMC2731139.

15: Medrano AZ, Barmada SJ, Biasini E, Harris DA. GFP-tagged mutant prion protein forms intra-axonal aggregates in transgenic mice. Neurobiol Dis. 2008 Jul;31(1):20-32. doi: 10.1016/j.nbd.2008.03.006. Epub 2008 Apr 7. PubMed PMID: 18514536; PubMed Central PMCID: PMC2536573.

16: Li A, Piccardo P, Barmada SJ, Ghetti B, Harris DA. Prion protein with an octapeptide insertion has impaired neuroprotective activity in transgenic mice. EMBO J. 2007 Jun 6;26(11):2777-85. Epub 2007 May 17. PubMed PMID: 17510630; PubMed Central PMCID: PMC1888682.

17: Szewczyk NJ, Peterson BK, Barmada SJ, Parkinson LP, Jacobson LA. Opposed growth factor signals control protein degradation in muscles of Caenorhabditis elegans. EMBO J. 2007 Feb 21;26(4):935-43. Epub 2007 Feb 8. PubMed PMID: 17290229; PubMed Central PMCID: PMC1852841.

18: Li A, Barmada SJ, Roth KA, Harris DA. N-terminally deleted forms of the prion protein activate both Bax-dependent and Bax-independent neurotoxic pathways. J Neurosci. 2007 Jan 24;27(4):852-9. PubMed PMID: 17251426.

19: Barmada SJ, Harris DA. Visualization of prion infection in transgenic mice expressing green fluorescent protein-tagged prion protein. J Neurosci. 2005 Jun 15;25(24):5824-32. PubMed PMID: 15958749.

20: Barmada S, Piccardo P, Yamaguchi K, Ghetti B, Harris DA. GFP-tagged prion protein is correctly localized and functionally active in the brains of transgenic mice. Neurobiol Dis. 2004 Aug;16(3):527-37. PubMed PMID: 15262264.

21: Ivanova L, Barmada S, Kummer T, Harris DA. Mutant prion proteins are partially retained in the endoplasmic reticulum. J Biol Chem. 2001 Nov 9;276(45):42409-21. Epub 2001 Aug 29. PubMed PMID: 11527974.

22: Szewczyk NJ, Hartman JJ, Barmada SJ, Jacobson LA. Genetic defects in acetylcholine signalling promote protein degradation in muscle cells of Caenorhabditis elegans. J Cell Sci. 2000 Jun;113 ( Pt 11):2003-10. PubMed PMID: 10806111.

23: Zdinak LA, Greenberg IB, Szewczyk NJ, Barmada SJ, Cardamone-Rayner M, Hartman JJ, Jacobson LA. Transgene-coded chimeric proteins as reporters of intracellular proteolysis: starvation-induced catabolism of a lacZ fusion protein in muscle cells of Caenorhabditis elegans. J Cell Biochem. 1997 Oct 1;67(1):143-53. PubMed PMID: 9328848.

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