Data from a 2x2 crossover trial on cerebrovascular deficiency adapted from Jones and Kenward (1989, p.90), where treatment A and treatment B are active drug and placebo, respectively. The outcome indicates if an electrocardiogram was judged abnormal (0) or normal (1). ## Responses Period ----------------------- --------- Group (1,1) (0,1) (1,0) (0,0) Total 1 2 ------------------------------------------------- AB 22 0 6 6 34 28 22 BA 18 4 2 9 33 20 22 -------------------------------------------------