Liver inflammation

Role of inflammation in lipoatrophy-induced diabetes: Subsequent to the studies we performed related to blood clot formation in fatless mice, we became interested in what caused the severe alterations in liver size and composition (ie. fatty liver) in the lipoatrophic mice that we bred.

We identified a pathway which appears involved in the progression of fatty liver and insulin resistance. We are now continuing these studies to better define the downstream actions of the pathway in our mouse model of lipoatrophy and diabetes.

Yang SJ, IglayReger HB, Kadouh HC, Bodary PF. Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy. Diabetologia. 2009 May;52(5):972-81.

http://www.ncbi.nlm.nih.gov/pubmed/19277603


There are human diseases which are similar to this mouse model we study. One such disease is called congenital generalized lipoatrophy. There are very interesting pictures and a summary of lipoatrophic and lipodystrophic syndromes at the following website:

http://www.ajronline.org/cgi/content/full/178/2/311

 

For more information please contact Dr. Bodary.