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Prolonged seizures increase subventricular zone-olfactory bulb neurogenesis in the adult rat. This confocal image of a parasagittal section through the distal rostral migratory stream (dense red band) and olfactory bulb (far right) shows green fluorescent protein (GFP)-labeled neuroblasts migrating to the olfactory bulb.  Proliferating cells were labeled 11 days earlier (and 2 days before chemoconvulsant seizure induction) by injection of retrovirus carrying a GFP reporter in the striatal subventricular zone.  Propidium iodide counterstain.  Chemoconvulsant-induced status epilepticus increases the numbers of immature neurons that migrate to the olfactory bulb, and also induces ectopic neuroblast migration into other forebrain structures.  Retroviral-GFP reporter courtesy of T. Palmer (Stanford University) and F. Gage (Salk Institute).

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Department of Neurology, University of Michigan, Ann Arbor, MI

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