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Prolonged
seizures increase subventricular zone-olfactory bulb neurogenesis
in the adult rat. This
confocal image of a parasagittal section through the distal rostral
migratory stream (dense red band)
and olfactory bulb (far right) shows green
fluorescent protein (GFP)-labeled neuroblasts migrating to the
olfactory bulb. Proliferating cells were labeled 11 days
earlier (and 2 days before chemoconvulsant seizure induction)
by injection of retrovirus carrying a GFP reporter in the striatal
subventricular zone. Propidium iodide counterstain. Chemoconvulsant-induced status epilepticus
increases the numbers of immature neurons that migrate to the
olfactory bulb, and also induces ectopic neuroblast migration
into other forebrain structures.
Retroviral-GFP reporter courtesy of T. Palmer (Stanford
University) and F. Gage (Salk Institute). |
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Contact:
parent@umich.edu
Department
of Neurology, University
of Michigan, Ann Arbor, MI
© 2003
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