Immunofluorescence
double-labeling for myelin oligodendrocyte glycoprotein (MOG,
red, expressed by oligodendrocytes)
and doublecortin (DCx, green, expressed
by immature neurons) shows stroke-induced neurogenesis after
transient middle cerebral artery occlusion in an adult rat.
In the hemisphere opposite the stroke (left panel), DCx expression
is confined to the striatal subventricular zone (SVZ, asterisk),
a region of persistent neurogenesis in the adult.
No DCx immunoreactivity is present in the striatum (Stm). In the infarcted hemisphere (right panel), DCx expression is
increased in the SVZ and many DCx-immunoreactive cells are seen
in the Stm adjacent to the infarct.
LV, lateral ventricle.
MOG antibody courtesy of Claude Bernard, Melbourne, Australia. |