Papers about anti-aging drugs:
Miller, R. A., D. E. Harrison, C. M. Astle, R. A. Floyd, K. Flurkey, K. L. Hensley, M. A. Javors, C. Leeuwenburgh, J. F. Nelson, E. Ongini, N. L. Nadon, H. R. Warner, R. Strong. 2007. An aging interventions testing program: study design and interim report. Aging Cell 6: 565 - 575. [PMC: 17578509] [PubMed]
Strong, R., R. A. Miller, C. M. Astle, R. A. Floyd, K. Flurkey, K. L. Hensley, M. A. Javors, C. Leeuwenburgh, J. F. Nelson, Ennio Ongini, N. L. Nadon, H. R. Warner, D. E. Harrison. 2008. Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 7:641 - 650. [PubMed]
Harrison, D. E., R. Strong, Z. D. Sharp, J. F. Nelson, C. M. Astle, K. Flurkey, N. L. Nadon, J. E. Wilkinson, K. Frenkel, C. S. Carter, M. Pahor, M. Javors, E. Fernandez, and R. A. Miller. 2009. Rapamycin fed from 20 months of age extends lifespan in genetically heterogeneous mice. Nature 460: 392 - 395. [PubMed]
Miller, R. A., D. Harrison, C. M. Astle, J. A. Baur, A. R. Boyd, R. de Cabo, E. Fernandez, K. Flurkey, M. A. Javors, J. F. Nelson, C. J. Orihuela, S. Pletcher, Z. D. Sharp, D. Sinclair, J. W. Starnes, J. E. Wilkinson, N. L. Nadon, and R. Strong. 2011. Rapamycin, but not resveratrol or simvastatin, extends lifespan of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 66: 191-201. [PubMed]
Papers about slow-aging mice:
[Older papers on this topic]
Flurkey, K., J. Papaconstantinou, R. A. Miller, and D. E. Harrison. 2001. Life span extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl. Acad. Sci. USA 98:6736-6741. [PubMed]
Miller, R. A., J. M. Harper, R. C. Dysko, S. J. Durkee, and S. N. Austad. 2002. Longer life spans and delayed maturation in wild-derived mice. Experimental Biology and Medicine 227:500-508. [PubMed]
Miller, R. A., G. Buehner, Y. Chang, J. M. Harper, R. Sigler, and M. Smith-Wheelock. 2005. Methionine-deficient diet extends mouse life span, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4:199-125. [PubMed]
Sun, L., A. A. Sadighi Akha, R. A. Miller, and J. M. Harper. 2009. Life span extension in mice by pre-weaning food restriction and by methionine restriction in middle age. J. Gerontol. Biol. Sci. Med. Sci. 64A: 711 - 722. [PubMed]
Harper, J. M., J. E. Wilkinson, and R. A. Miller. 2010. Macrophage migration inhibitory factor knockout mice are long-lived and respond to caloric restriction. FASEB Journal 24: 2435-2442. [PubMed]
Panici, J. A., J. M. Harper, R. A Miller, A. Bartke, A. Spong, and M. M. Masternak. 2010. Early life growth hormone treatment shortened the longevity and decreased cellular stress resistance in long-living mice. FASEB Journal 24: 5073 - 5079. [PubMed]
Papers about comparative biology of aging:
Harper, J. M., A. B. Salmon, S. F. Leiser, A. T. Galecki, and R. A. Miller. 2007. Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone. Aging Cell 6:1-13. [PubMed]
Salmon, A. B., A. A. Sadighi Akha, R. Buffenstein and R. A. Miller. 2008. Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress. J. Gerontol. Biol. Sci. 63: 232 - 241.
Miller, R. A., J. B. Williams, V. Kiklevich, S. Austad, and J. M. Harper. 2011. Comparative cellular biogerontology: primer and prospectus. Ageing Research Reviews 10:181-190. [PubMed]
Harper, J. M., M. Wang, A. T. Galecki, J. Ro, J. B. Williams and R.A. Miller. 2011. Fibroblasts from long-lived bird species are resistant to multiple forms of stress. J. Experimental Biology 214:1902 - 1910. [PubMed]
Papers about cell stress resistance and aging:
Murakami, S., A. Salmon, and R. A. Miller. 2003. Multiplex stress resistance in cells from long-lived dwarf mice. FASEB Journal express article 10.1096/fj.02-1092fje. FASEB Journal 17: 1565-1566. [PubMed]
Salmon, A. B., S. Murakami, A. Bartke, J. Kopchick, K. Yasumura, and R. A. Miller. 2005. Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. American Journal of Physiology: Endocrinology and Metabolism 289:E23-E29. [PubMed]
Swindell, W. R., M. M. Masternak, J. J. Kopchick, C. A. Conover, A. Bartke, and R. A. Miller. 2009. Endocrine regulation of heat shock protein mRNA levels in long-lived dwarf mice. Mechanisms of Aging and Development 130:393-400. [PubMed]
Sun, L. Y., M. J. Steinbaugh, M. M. Masternak , A. Bartke and R. A. Miller. 2009. Fibroblasts from long-lived mutant mice show diminished ERK phosphorylation but exaggerated induction of immediate early genes. Free Radicals Biol. Med. 47:1753-61. [PubMed]
Leiser, S. F., and R. A. Miller. 2010. Nrf2 Signaling: a mechanism for cellular stress resistance in long-lived mice. Molecular and Cellular Biology 30:871-884. [PubMed]
Sun, L. Y., A. F. Bokov, A. Richardson, and R. A. Miller. 2011. Hepatic response to oxidative injury: qualitative differences in long-lived Ames dwarf mice. FASEB Journal 25:398-408. [PubMed]
Miller, R. A., D. Dolan, M. Han, W. Kohler, and J. Schacht. 2011. Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice. Aging Cell 10:362-363. [PubMed]
Sadighi Akha, A. A., J. M. Harper, A. B. Salmon, B. A. Schroeder, D. T. Rutkowski and R. A. Miller. 2011. Heightened induction of pro-apoptotic signals in response to ER stress in primary fibroblasts from a mouse model of longevity. J. Biol. Chem. 286:30344-30351. [PubMed]
Garcia, G. G., and R. A. Miller. 2003. Age-related defects in CD4+ T cell activation reversed by glycoprotein endopeptidase. European Journal of Immunology 33:3464 - 3472. [PubMed]
Garcia, G. G., A. A. Sadighi Akha, and R. A. Miller. 2007. Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells. J. Immunol. 179: 6403-6409. [PubMed]
Garcia, G. G. and R. A. Miller. 2009. Age-related changes in Lck-Vav signaling pathways in mouse CD4 T cells. Cellular Immunology 259:100 - 104. [PubMed]
Garcia, G. G. and R. A. Miller. 2011. Age-related defects in the cytoskeleton signaling pathways of CD4 T cells. Ageing Research Reviews 10:26-34. [PubMed]
Garcia, G. G., and R. A. Miller. 2011. Ex vivo enzymatic treatment of aged CD4 T cells restores antigen-driven CD69 expression and proliferation in mice. Immunobiology. 216: 66-71. [PubMed]
Miller, R. A. and C. Chrisp. 2002. T cell subset patterns that predict resistance to spontaneous lymphoma, mammary adenocarcinoma, and fibrosarcoma in mice. J. Immunol. 169:1619-1625. [PubMed]
Harper, J. M., A. T. Galecki, D. T. Burke, and R. A. Miller. 2004. Body weight, hormones and T-cell subsets as predictors of lifespan in genetically heterogeneous mice. Mechanisms of Ageing and Development 125:381-390. [PubMed]
Swindell, W. R., J. M. Harper and R. A. Miller. 2008. How long will my mouse live? Machine learning approaches for prediction of mouse lifespan. J. Gerontol. Biol. Sci. 63A: 895 - 906. [PubMed]
Miller, R. A., J. Kreider, A. Galecki, and S. A. Goldstein. 2011. Preservation of femoral bone thickness in middle age predicts survival in genetically heterogeneous mice. Aging Cell 10: 383 - 391. [PubMed]
Papers about gene mapping [link]:
Papers about gene expression screening [link]:
Miller, R. A. 1991. Gerontology as oncology: research on aging as the key to the understanding of cancer. Cancer 68: 2496-2501.
Miller, R. A. 1996. The aging immune system: primer and prospectus. Science 273:70-74. [PubMed]
Miller, R. A. 1997. When Will the Biology of Aging Become Useful? Future Landmarks in Biomedical Gerontology. J. American Geriatrics Soc. 45:1258-1267. [PubMed]
Miller, R. A. 1999. Aging and Immune Function. In: Fundamental Immunology, Fourth Edition, W. E. Paul, Editor, Lippincott-Raven, Philadelphia. Chapter 28, pages 947 - 966.
Miller, R. A. and N. Nadon. 2000. Principles of animal use for gerontological research. Journal of Gerontology: Biological Sciences 55A:B117 - 124. [PubMed]
Miller, R. A. 2002. Extending life: scientific prospects and political obstacles. Milbank Quarterly 80:155 - 174.
Miller, R. A. 2004. "Accelerated Aging": A Primrose Path to Insight? Aging Cell 3:47-51. [PubMed]
Miller, R. A. 2005. The anti-aging sweepstakes: catalase runs for the ROSes. Science 308:1875-1876. [PubMed]
Miller, R. A., and S. N. Austad. 2006. Growth and aging: why do big dogs die young? Handbook of the Biology of Aging, 6th Edition. E. J. Masoro and S. N. Austad, Eds. Academic Press, NY. Chapter 19, pages 512 - 533.
Warner, H., J. Anderson, S. Austad, E. Bergamini, D. Bredesen, R. Butler, B. A. Carnes, B. F. C. Clark, V. Cristofalo, J. Faulkner, L. Guarente, D. Harrison, T. Kirkwood, G. Lithgow, G. Martin, E. Masoro, S. Melov, R. A. Miller, S. J. Olshansky, L. Partridge, O. Pereira-Smith, T. Perls, A. Richardson, J. Smith, T. von Zglinicki, E. Wang, J. Y. Wei, and T. F. Williams. 2005. Science fact and the SENS agenda: What can we reasonably expect from ageing research? EMBO Reports 6:1006-1008. [PubMed]
Miller, R. A. 2007. Of aging mice and men. Science 318: 390. [PubMed]
Butler, R. N., R. A. Miller, D. Perry, B. A. Carnes, T. F. Williams, C. Cassel, J. Brody, M. A. Bernard, L. Partridge, T. Kirkwood, G. M. Martin, S. J. Olshansky. 2008. New model of health promotion and disease prevention for the 21st century. British Medical Journal 337: 149 - 150. [PubMed]
Lithgow, G. J. and R. A. Miller. 2008. The determination of aging rate by coordinated resistance to multiple forms of stress. In: The Molecular Biology of Aging, L.Guarente, L. Partridge, and D. Wallace, eds. Cold Spring Harbor Press, NY.
Miller, R. A. 2009. Cell stress and aging: new emphasis on multiplex resistance mechanisms. J Gerontol A Biol Sci Med Sci. 64:179-82. [PubMed]
Miller, R. A. 2009. "Dividends" from research on aging - can biogerontologists, at long last, find something useful to do? J Gerontol A Biol Sci Med Sci. 64:157-160. [PubMed]
Schacht, J., R. Altschuler, D. T. Burke, S. Chen, D, Dolan, A. T. Galecki, D. Kohrman, and R. A. Miller. Alleles that modulate late life hearing in genetically heterogeneous mice.
Moorad, J. A., D. E. L. Promislow, N. Flesness, and R.A. Miller. A comparative assessment of univariate longevity measures using zoological animal records.