Interventions
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Review papers
Submitted papers

Miller Home Page

Murakami, S., A. Salmon, and R. A. Miller.  2003.  Multiplex stress resistance in cells from long-lived dwarf mice.  FASEB Journal express article 10.1096/fj.02-1092fje.  FASEB Journal 17: 1565-1566.  [PubMed]

Salmon, A. B., S. Murakami, A. Bartke, J. Kopchick, K. Yasumura, and R. A. Miller.  2005.  Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress.  American Journal of Physiology: Endocrinology and Metabolism 289:E23-E29.  [PubMed]

Maynard, S. P., and R. A. Miller.  2006.  Fibroblasts from long-lived Snell dwarf mice are resistant to oxygen-induced cell growth arrest in vitro.  Aging Cell 5: 89 – 96.  [PubMed]

(*) Leiser,  S. F., (*) A. B. Salmon, and R. A. Miller.  2006.  Correlated resistance to glucose deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf mice.  (*) joint first authors.  Mechanisms of Ageing and Development 127:821 - 829.  [PubMed]

Harper, J. M., A. B. Salmon, Y. Chang, M. Bonkowski, A. Bartke and R. A. Miller.  2006.  Stress resistance and aging: Influence of genes and nutrition.  Mech. Ageing Dev. 127:687 – 694.   [PubMed]

Harper, J. M., A. B. Salmon, S. F. Leiser, A. T. Galecki, and R. A. Miller.  2007.  Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone.  Aging Cell 6:1-13.  [PubMed]

Eisenbraun, M. D., A. Tamir, and R. A. Miller. 2000. Altered composition of the immunological synapse in an anergic, age-dependent memory T cell subset. J. Immunology 164:6105-6112.  [PubMed]

Tamir, A., M. D. Eisenbraun, G. G. Garcia, and R. A. Miller. 2000. Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interaction. J. Immunol. 165:1243-1251.  [PubMed]

Garcia, G. G., and R. A. Miller. 2001. Single-cell analyses reveal two defects in peptide-specific activation of naïve T cells from aged mice. J. Immunol. 166:3151-3157.  [PubMed]

Garcia, G. G., and R. A. Miller. 2002. Age-dependent defects in TCR-triggered cytoskeletal rearrangement in CD4+ T cells. J. Immunol. 169:5021-5027. [PubMed]

Garcia, G. G., and R. A. Miller.  2003.  Age-related defects in CD4+ T cell activation reversed by glycoprotein endopeptidase.  European Journal of Immunology 33:3464 - 3472.  [PubMed]

Garcia, G. G., S. B. Berger, A. A. Sadighi Akha, and R. A. Miller.  2005.  Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cells.  Eur. J. Immunol. 35: 622-631. [PubMed]

[Review] Miller, R. A., S. B. Berger, D. T. Burke, A. Galecki, G. G. Garcia, J. M. Harper, and A. A. Sadighi-Akha.  2005.  T cells in aging mice: genetic, developmental and biochemical analyses.  Immunological Reviews 205: 94 – 103.  [PubMed]

[Review] Sadighi Akha, A., and R. A. Miller.  2005.  Signal transduction in the aging immune system.  Current Opinion in Immunology 17:486 - 491..  [PubMed]

Sadighi Akha, A. A., S. B. Berger, R. A. Miller.  2006.  Enhancement of CD8 T cell function through modifying surface glycoproteins in young and old mice.  Immunology 119: 187 - 194.  [PubMed]

Berger, S. B., A. A. Sadighi Akha, R. A. Miller, and G. G. Garcia.  2006.  CD43-independent augmentation of mouse T cell function by glycoprotein cleaving enzymes.  Immunology 119: 178 - 186.  [PubMed]

Garcia, G. G., A. A. Sadighi Akha, and R. A. Miller.   2007.  Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells.  J. Immunol. 179: 6403-6409.  [PubMed]

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Miller, R. A., D. E. Harrison, C. M. Astle, R. A. Floyd, K. Flurkey, K. L. Hensley, M. A. Javors, C. Leeuwenburgh, J. F. Nelson, E. Ongini, N. L. Nadon, H. R. Warner, R. Strong.  2007. An aging interventions testing program: study design and interim report.  Aging Cell 6: 565 - 575.  [PubMed]

Papers about biomarkers of aging:

Miller, R. A. 1997. Age-related changes in T cell surface markers: a longitudinal analysis in genetically heterogeneous mice. Mechanisms of Ageing and Development 96:181-196.  [PubMed]

Miller, R. A., C. Chrisp, and A. Galecki. 1997. CD4 memory T cell levels predict lifespan in genetically heterogeneous mice. FASEB Journal 11:775-783.  [PubMed]

Miller, R. A. 2001. Biomarkers of aging: prediction of longevity using age-sensitive T cell subset determinations in a middle-aged, genetically heterogeneous mouse population. J. Gerontol. Biol. Sci. 56A:B180-B186.  [PubMed]

Miller, R. A. and C. Chrisp.  2002.  T cell subset patterns that predict resistance to spontaneous lymphoma, mammary adenocarcinoma, and fibrosarcoma in mice. J. Immunol. 169:1619-1625.  [PubMed]

Miller, R. A., J. M. Harper, A. Galecki, and D. T. Burke. 2002.  Big mice die young: early-life body weight predicts longevity in genetically heterogeneous mice. Aging Cell 1:22 - 29.  [PubMed]

Harper, J. M., N. Wolf, A. T. Galecki, S. L. Pinkosky, and R. A. Miller.  2003.  Hormone levels and cataract scores as sex-specific, mid-life predictors of longevity in genetically heterogeneous mice.  Mech. Ageing and Development 124:801-810.  [PubMed]

Harper, J. M., A. T. Galecki, D. T. Burke, and R. A. Miller.  2004.  Body weight, hormones and T-cell subsets as predictors of lifespan in genetically heterogeneous mice.  Mechanisms of Ageing and Development 125:381-390. [PubMed]

Jackson, A. U., A. Fornés, A. Galecki, R. A. Miller, and D. T. Burke. 1999. Multiple trait QTL analysis using a large mouse sibship. Genetics 151:785-795.  [PubMed]

[Review] Miller, R. A. 1999. Kleemeier Award Lecture: Are There Genes for Aging? J. Gerontology: Biological Sciences 54A:B297-B307.  [PubMed]

Jackson, A. U., A. T. Galecki, D. T. Burke, and R. A. Miller.  2003.  Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets.  Genes and Immunity 4:30-39. [PubMed]

Volkman, S. K. A.T. Galecki, D. T. Burke, M. R. Paczas, M. R. Moalli, R. A. Miller, and S. A. Goldstein.  2003.  Quantitative trait loci for femoral size and shape in a genetically heterogeneous mouse population.  Journal of Bone and Mineral Research 18:1497 -1505.  [PubMed]

Harper, J. M., A. T. Galecki, D. T. Burke, S. L. Pinkosky, and R. A. Miller.  2003.  Quantitative trait loci for insulin-like growth factor-I, leptin, thyroxine, and corticosterone in genetically heterogeneous mice.  Physiological Genomics 15:44-51.  [PubMed]

Volkman, S. K., A. T. Galecki, D. T. Burke, R. A. Miller, and S. A. Goldstein.  2004.  Quantitative trait loci that modulate femoral mechanical properties in a genetically heterogeneous mouse population.  J. Bone and Mineral Research 19:1497 - 1505. [PubMed]

Wolf, N., A. Galecki, R. Lipman, S. Chen, M. Smith-Wheelock, D. Burke, and R. Miller.  2004.  Quantitative trait locus mapping for age-related cataract severity and synechia prevalence using four-way cross mice.  Invest. Ophthalmology and Visual Science 45:1922-1929.  [PubMed]

Wisser, K. C., J. A. Schauerte, D. T. Burke, A. Galecki, S. Chen, R. A. Miller, and A. Gafni.  2004.  Mapping tissue-specific genes correlated with age-dependent changes in protein stability and function.  Archives of Biochemistry and Biophysics 432:58-70. [PubMed]

Lipman, R., A. Galecki, D. T. Burke and R. A. Miller.  2004.  Genetic loci that influence cause of death in a heterogeneous mouse stock.  J. Gerontol. Biol. Sci. 59A: 977 – 983.  [PubMed]

Hanlon, P., A. Lorenz, Z. Shao, J. Harper, A. T. Galecki, R. A. Miller, and D. T. Burke.  2006.  Three-locus and four-locus QTL interactions influence mouse insulin-like growth factor-I.  Physiological Genomics 26:46 – 54.  [PubMed]

Reeves, G. M., B. R. McCreadie, S. Chen, A. T. Galecki, D. T. Burke, R. A. Miller, and S. A. Goldstein.  2007.  Quantitative trait loci modulate vertebral morphology and mechanical properties in a genetically heterogeneous mouse population.  Bone 40:433-443.  [PubMed]

[Review] Miller, R. A., S. Austad, D. Burke, C. Chrisp, R. Dysko, A. Galecki, A. Jackson, and V. Monnier. 1999. Exotic mice as models for aging research: polemic and prospectus. Neurobiology of Aging 20:217-231.  [PubMed]

Miller, R. A. and S. Austad. 1999. Large animals in the fast lane (letter). Science 285:199.

Miller, R. A., R. Dysko, C. Chrisp, R. Seguin, L. Linsalata, G. Buehner, J. M. Harper and S. Austad. 2000. Mouse stocks derived from tropical islands: new models for genetic analysis of life history traits. J. Zoology 250:95-104.

Miller, R. A., C. Chrisp, and W. Atchley. 2000. Differential longevity in mouse stocks selected for early life growth trajectory. J. Gerontol. Biol. Sci. 55A:B455-B461.  [PubMed]

Flurkey, K., J. Papaconstantinou, R. A. Miller, and D. E. Harrison. 2001. Life span extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc. Natl. Acad. Sci. USA 98:6736-6741.  [PubMed]

Bartke, A., J. C. Wright, J. A. Mattison, D. K. Ingram, R. A. Miller, and G. S. Roth. Extending the lifepan of long-lived mice. 2001. Nature 414: 412.  [PubMed]

[Review] Miller, R. A. Genetics of increased longevity and retarded aging in mice. 2001. Handbook of the Biology of Aging, 5th Edition; E. J. Masoro and S. N. Austad, editors; Academic Press, NY. Chapter 14, pp. 369 – 395.

Miller, R. A., J. M. Harper, R. C. Dysko, S. J. Durkee, and S. N. Austad. 2002. Longer life spans and delayed maturation in wild-derived mice. Experimental Biology and Medicine 227:500-508. [PubMed]

Bartke, A. J. C. Wright, J. A. Mattison, D. K. Ingram, R. A. Miller, and G. S. Roth. Letter: Dietary restriction and life span. 2002. Science 296: 2141 – 2142.  [PubMed]

Vergara, M., M. Smith-Wheelock, J. M. Harper, R. Sigler, and R. A. Miller.  2004.  Hormone-treated Snell dwarf mice regain fertility but remain long-lived and disease resistant.  J. Gerontol. Biol. Sci. 59:1244-1250. [PubMed]

Harper, J. M., S. J. Durkee, M. Smith-Wheelock and R. A. Miller.  2005.  Hyperglycemia, impaired glucose tolerance and elevated glycated hemoglobin levels in a long-lived mouse stock.  Experimental Gerontology 40: 303- 314.  [PubMed]

Miller, R. A., G. Buehner, Y. Chang, J. M. Harper, R. Sigler, and M. Smith-Wheelock.  2005.  Methionine-deficient diet extends mouse life span, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance.  Aging Cell 4:199-125.  [PubMed]

Hulbert, A. J., S. C. Faulks, J. M. Harper, R. A. Miller, R. Buffenstein. 2006.  Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes.  Mechanisms of Ageing and Development 127:653 – 657.  [PubMed]

Harper, J. M., S. J. Durkee, R. C. Dysko, S. N. Austad and R. A. Miller.  2006.  Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice. J. Gerontol. A Biol. Sci. Med. Sci. 61: 1019 - 1029.  [PubMed]

Papers about gene expression screening:

Dozmorov, I., A. Bartke, and R. A. Miller. 2001. Array-based expression analysis of mouse liver genes:effect of age and of the longevity mutant Prop1^df. J. Gerontol. Biol. Sci., 56A: B72-B80.  [PubMed]

Miller, R. A., A. Galecki, and R. J. Shmookler-Reis. 2001. Interpretation, design and analysis of gene array expression experiments. J. Gerontol. Biol. Sci. 56A: B52-B57.  [PubMed]

Miller, R. A., A. Galecki, and R. J. Shmookler-Reis. 2001. Letter to the editor on "Interpretation, Design, and Analysis of Gene Array Expression Experiments." J. Gerontol. Biol. Sci. 56A:B329 – B330.

Dozmorov, I., A. Galecki, Y. Chang, R. Krzesicki, M. Vergara and R. A. Miller. 2002.  Gene expression profile of long-lived Snell dwarf mice. J. Gerontol. Biol. Sci., 57A:B99-B108. [PubMed]

Miller, R. A., Y. Chang, A. T. Galecki, K. Al-Regaiey, J. J. Kopchick, and A. Bartke. 2002.  Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice. Molecular Endocrinology 16:2657 - 2666. [PubMed]

Review papers and miscellaneous:

Miller, R. A. 1991. Gerontology as oncology: research on aging as the key to the understanding of cancer. Cancer 68: 2496-2501.

Miller, R. A. 1996. The aging immune system: primer and prospectus. Science 273:70-74.  [PubMed]

Miller, R. A. 1997. When Will the Biology of Aging Become Useful? Future Landmarks in Biomedical Gerontology. J. American Geriatrics Soc. 45:1258-1267.  [PubMed]

Miller, R. A. 1999. Aging and Immune Function. In: Fundamental Immunology, Fourth Edition, W. E. Paul, Editor, Lippincott-Raven, Philadelphia. Chapter 28, pages 947 – 966.

Miller, R. A. and N. Nadon. 2000. Principles of animal use for gerontological research. Journal of Gerontology: Biological Sciences 55A:B117 – 124.  [PubMed]

Miller, R. A. 2002. Extending life: scientific prospects and political obstacles. Milbank Quarterly 80:155 – 174.

Miller, R. A.  2003.  The biology of aging and longevity.  In: Principles of Geriatric Medicine and Gerontology, 5th Edition, W. R. Hazzard et al., eds., McGraw-Hill, Inc., NY, Chapter 1, pp 3 – 15.

Miller, R. A.  2004.   "Accelerated Aging": A Primrose Path to Insight?  Aging Cell 3:47-51.  [PubMed]

Miller, R. A.  2004.  Rebuttal to Hasty and Vijg, "Accelerated aging by mouse reverse genetics: a rational approach to understand longevity."  Aging Cell 3:53-54.  [PubMed]

Miller, R. A.  2005.  The anti-aging sweepstakes: catalase runs for the ROSes.  Science 308:1875-1876.  [PubMed]

Miller, R. A., and S. N. Austad.  2006.  Growth and aging: why do big dogs die young?  Handbook of the Biology of Aging, 6^th Edition.  E. J. Masoro and S. N. Austad, Eds.  Academic Press, NY.  Chapter 19, pages 512 – 533.

Warner, H., J. Anderson, S. Austad, E. Bergamini, D. Bredesen, R. Butler, B. A. Carnes, B. F. C. Clark, V. Cristofalo, J. Faulkner, L. Guarente, D. Harrison, T. Kirkwood, G. Lithgow, G. Martin, E. Masoro, S. Melov, R. A. Miller, S. J. Olshansky, L. Partridge, O. Pereira-Smith, T. Perls, A. Richardson, J. Smith, T. von Zglinicki, E. Wang, J. Y. Wei, and T. F. Williams.  2005.  Science fact and the SENS agenda: What can we reasonably expect from ageing research?  EMBO Reports 6:1006-1008.  [PubMed]

Miller, R. A.  2007.  Of aging mice and men.  Science 318: 390. [PubMed]

Lithgow, G. J. and R. A. Miller.  2008.  The determination of aging rate by coordinated resistance to multiple forms of stress.   In: The Molecular Biology of Aging, L.Guarente, L. Partridge, and D. Wallace, eds.  Cold Spring Harbor Press, NY. 

Submitted papers (update: Dec, 2007):

Salmon, A. B., M. Ljungman, and R. A. Miller.  Cells from long-lived mutant mice exhibit enhanced repair of UV lesions.  

Salmon, A. B., A. A. Sadighi Akha, R. Buffenstein and R. A. Miller.  Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, UV light, and ER stress. 

Swindell, W. R., J. M. Harper and R. A. Miller.   How long will my mouse live? Machine learning approaches for prediction of mouse lifespan.  .

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