Supplementary Table for Harper, Galecki, Burke, Pinkosky, and Miller, "Quantitative Trait Loci for Insulin-like Growth Factor-I, Leptin, Thyroxine, and Corticosterone in Genetically Heterogeneous Mice," submitted to Physiological Genomics
Supplementary Table 1: Suggestive Gene/Trait Associations (Experimentwise 0.05 < P <0.20)
|
Marker |
Position (Kbp) |
Position (cM) |
Inheritance |
Hormone (Age mo) |
N |
Effect (SE) |
Nominal p-value |
Experimentwise p-value |
Comparison |
|
D8Mit51 |
88132 |
41.0 |
Mat |
IGF-I (4) |
929 |
39 (12) |
<0.001 |
0.14 |
B6 > C |
D15Mit63 |
65693 |
29.2 |
Mat |
IGF-I (15) |
895 |
44 (13) |
<0.01 |
0.14 |
C > B6 |
|
D2Mit58 |
109197 |
51.4 |
Mat |
Leptin (15) |
778 |
1.3 (0.4) |
<0.001 |
0.11 |
B6 > C |
|
D11Mit289 |
95634 |
55.0 |
Pat |
Leptin (15) |
780 |
1.3 (0.4) |
<0.01 |
0.08 |
C3 > D2 |
|
D13Mit64 |
44655 |
30.0 |
Mat |
Leptin (15) |
765 |
1.3 (0.4) |
<0.001 |
0.09 |
C > B6 |
|
D6Mit268 |
34192 |
15.6 |
Mat |
T4 (4) |
958 |
0.4 (0.1) |
<0.001 |
0.13 |
C > B6 |
|
D15Mit100 |
51347 |
21.0 |
Mat |
T4 (4) |
957 |
0.4 (0.1) |
<0.01 |
0.17 |
C3 > D2 |
|
D7Mit25 |
27386 |
16.0 |
Mat |
927 |
0.3 (0.1) |
<0.01 |
0.11 |
C > B6 |
|
|
D15Mit63 |
65693 |
29.2 |
Pat |
T4 (15) |
918 |
0.3 (0.1) |
<0.001 |
0.19 |
C3 > D2 |
Notes: Inheritance indicates whether the allele was either maternally (Mat) or paternally (Pat) derived. The estimated effect of each marker is the absolute difference between mean levels of the indicated trait in the two groups of mice differing at the indicated locus. Comparison indicates which allele results in the larger value of a particular trait. When the genome scan showed two or more closely linked markers with significant associations to the same hormone, only the one with the stronger association is listed in the table. Abbreviations: C57BL/6J (B6), BALB/cJ (C), C3H/HeJ (C3), DBA/2J (D2), not available (NA).