Publications
Click on reference
number for direct link to PubMed!
1.
Johnston, L.J., A.J. Thulin, W.C. Weldon, O.A. MacDougald,
and E.R. Miller. 1988. Carbadox-Pyrantel Tartrate Combination
and Elevated Dietary Protein: Effects on Pig Performance
and Body Composition. Nutrition Reports International. 38:
799 - 804.
2.
MacDougald, O.A., A.J. Thulin, W.C. Weldon, J.J. Pestka,
and R.L. Fogwell. 1990. Effects of Immunizing Gilts Against
Zearalenone on Height of Vaginal Epithelium and Urinary
Excretion of Zearalenone. Journal of Animal Science. 68:
3713 - 3718.
3.
MacDougald, O.A., A.J. Thulin, and J.J. Pestka. 1990. Determination
of Zearalenone and Related Metabolites in Porcine Urine
by Modified Enzyme-Linked Immunosorbent Assay. Journal of
the Association of Official Analytical Chemists. 73: 65
- 68.
4.
Weldon, W.C., A.J. Thulin, O.A. MacDougald, L.J. Johnston,
E.R. Miller, and H.A. Tucker. 1991. Effects of Elevated
Energy and Protein during Late Gestation on Mammary Development
in Gilts. Journal of Animal Science. 69: 194 - 200.
5.
MacDougald, O.A. and D.B. Jump. 1991. Identification of
Functional Cis-Acting Elements Within the Rat Liver S14
Promoter. Biochemical Journal. 280: 761 - 767.
6.
MacDougald, O.A., S.D. Clarke, and D.B. Jump. 1992. Tissue-Specificity
of S14 and Fatty Acid Synthase In Vitro Transcription. Biochemical
and Biophysical Research Communications. 182: 631 - 637.
7.
MacDougald, O.A. and D.B. Jump. 1992. Localization of an
Adipocyte-Specific Retinoic Acid Response Domain Controlling
S14 Gene Transcription. Biochemical and Biophysical Research
Communications. 188: 470 - 476.
8.
Jump, D.B. and O.A. MacDougald. 1993. Hormonal Regulation
of Gene Expression in Cultured Adipocytes. Journal of Animal
Science. 71(Suppl. 2): 56-64.
9.
Jump, D.B., S.D. Clarke, O.A. MacDougald, and A. Thelen.
1993. Polyunsaturated Fatty Acids Inhibit S14 Gene Transcription
in Rat Liver and Cultured Hepatocytes. Proceedings of the
National Academy of Sciences, USA. 90: 8454 - 8458.
10.
Lin, F-T., O. A. MacDougald, A.M. Diehl, and M.D. Lane.
1993. A 30-kDa Alternative Translation Product of the CCAAT/Enhancer
Binding Proteina message: Transcriptional Activator lacking
Antimitotic Activity. Proceedings of the National Academy
of Sciences, USA. 90: 9606-9610.
11.
Landschulz, K.T., D.B Jump, O.A. MacDougald, and M.D. Lane.
1994. Transcriptional Control of the Stearoyl-CoA Desaturase-1
Gene by Polyunsaturated Fatty Acids. Biochemical Biophysical
Research Communications. 200: 763-768.
12.
MacDougald, O.A., P. Cornelius, F.-T. Lin, S.S. Chen, and
M.D. Lane. 1994. Glucocorticoids Reciprocally Regulate Expression
of the CCAAT/Enhancer-binding Protein a and d Genes in 3T3-L1
Adipocytes and White Adipose Tissue. Journal of Biological
Chemistry. 269: 19041-19047.
13.
MacDougald, O.A., P. Cornelius, and M.D. Lane. 1995. Insulin
Regulates Transcription of the CCAAT/Enhancer Binding Protein
(C/EBP) a, b and d Genes in Fully-Differentiated 3T3-L1
Adipocytes. Journal of Biological Chemistry. 270: 647-654.
14.
Potter, J.J., O.A. MacDougald, and E. Mezey. 1995. Regulation
of Rat Alcohol Dehydrogenase by Cyclic AMP in Primary Hepatocyte
Culture. Archives of Biochemistry and Biophysics. 321: 329-335.
15.
MacDougald, O.A., Hwang, C. Fan, H. and M.D. Lane. 1995.
Regulated Expression of the obese Gene Product (Leptin)
in White Adipose Tissue and 3T3-L1 Adipocytes. Proceedings
of the National Academy of Sciences, USA. 92: 9034-9037.
16.
Hwang, C.S., Mandrup, S., MacDougald, O.A., Geiman, D.E.
and M.D. Lane. 1996. Transcriptional Activation of the Obese
Gene by CCAAT/Enhancer Binding Protein a. Proceedings of
the National Academy of Sciences. USA. 93: 873-877.
17.
Mandrup, S., T. Loftus, O.A. MacDougald, F. Kuhajda, and
M.D. Lane. 1997. Obese Gene Expression at In Vivo Levels
by Fat Pads Derived from s.c. Implanted 3T3-F442A Preadipocytes.
Proceedings of the National Academy of Sciences. U.S.A.
94: 4300-4305.
18.
Hemati, N., S.E. Ross, R.L. Erickson, G.E. Groblewski, and
O.A. MacDougald. 1997. Signaling Pathways through which
Insulin regulates CCAAT/Enhancer Binding Protein a (C/EBPa)
Phosphorylation and Gene Expression in 3T3-L1 Adipocytes:
Correlation with GLUT4 Gene Expression. Journal of Biological
Chemistry. 272: 25913-25919.
19.
Hemati, N., R.L. Erickson, S.E. Ross, R. Liu, and O.A. MacDougald.
1998. Regulation of CCAAT/Enhancer Binding Protein a (C/EBPa)
Gene Expression by Thiazolidinediones in 3T3-L1 Adipocytes.
Biochemical Biophysical Research Communications. 244: 20-25.
20.
Becker, D.J. and O.A. MacDougald. 1999. Transfection of
3T3-L1 Adipocytes by Gene Gun-Mediated Transfer. BioTechniques.
26: 660-668.
21.
Liao, J., G. Piwien de Pilipuk, S.E. Ross, C. L. Hodge,
L. Seally, O.A. MacDougald, and J. Schwartz. 1999. C/EBPb
Contributes to GH-Regulated Transcription of c-Fos. Journal
of Biological Chemistry. 274: 31597-31604.
22.
Ross, S.E., R.L. Erickson, N. Hemati, and O.A. MacDougald.
1999. Glycogen Synthase Kinase 3 is an Insulin-Regulated
C/EBPa Kinase. Molecular and Cellular Biology 19: 8433-8441.
23.
Hajra, A.K., A.K. Das, L.K. Larkins, N. Hemati, R.L. Erickson,
and O.A. MacDougald. 2000. Induction of the Peroxisomal
Glycerolipid-synthesizing Enzymes during Differentiation
of 3T3-L1 Adipocytes: Role in Triacylglycerol Synthesis.
Journal of Biological Chemistry. 275: 9441-9446.
24.
Ross, S.E., N. Hemati, K.A. Longo, C. Bennet, P. Lucas,
and R.L. Erickson, O.A. MacDougald. 2000. Inhibition of
Adipogenesis by Wnt Signaling. Science 289: 950-953.
25.
Erickson, R.L., N Hemati, S.E. Ross, and O. A. MacDougald.
2001. p300 Coactivates the Adipogenic Transcription Factor
C/EBPa. Journal of Biological Chemistry. 276: 16348-16355.
26.
Piwien-Pilipuk, G., D. van Mater, S.E. Ross, O.A. MacDougald,
and J. Schwartz. 2001. Growth Hormone Regulates Phosphorylation
and Function of C/EBPb. Mediation of Growth Hormone-Promoted
Dephosphorylation of C/EBPb by Akt and Glycogen Synthase
Kinase-3. Journal of Biological Chemistry. 276: 19664-19671.
27.
Schaufele, F., J.F. Enwright, III, X. Wang, C. Teoh, R.
Srihari, R. Erickson, O.A. MacDougald, and R.N. Day. 2001.
CCAAT/enhancer binding protein a assembles essential cooperating
factors in common subnuclear domains. Molecular Endocrinology
15: 1665-1676.
28. Douglas, K.R., M.L. Brinkmeier, J.A. Kennell, P.
Eswara, T.A. Harrison, A.I. Patrianakos, B.S. Sprecher,
M.A. Potok, R.H. Lyons, Jr., O.A. MacDougald, and S.A. Camper.
2001. Identification of Members of the Wnt Signaling Pathway
in the Embryonic Pituitary Gland. Mammalian Genome 12: 843-851.
29. You, Z., Z. Zhang, D. Saims, S.
Chen, A.M. Brown, K.-L. Guan, O.A. MacDougald, G.Evans,
J. Kitajewski, and C.-Y. Wang. 2002. Transcriptional Control
of Apoptosis by Wnt Signaling: Induction of Cox-2 and WISP-1
to Suppress c-myc-mediated Apoptosis. Journal of Cell Biology
157: 429-440.
30. Piwien-Pilipuk, G., O.A. MacDougald, and J. Schwartz.
2002. Growth hormone regulates MAPK-dependent phosphorylation
of C/EBP . Journal of Biological Chemistry 277: 44557-44565.
31. Ross, S.E., R.L. Erickson, I. Gerin, P.M. DeRose,
L. Bajnok, K.A. Longo, D.E. Misek, R. Kuick, S.M. Hanash,
K.B. Atkins, S. Mahle, H.I. Nebb, L. Madsen, K. Kristiansen,
and O.A. MacDougald. 2002. Microarray analyses during adipogenesis:
understanding the effects of Wnt-signaling on adipogenesis
and the roles of LXR in adipocyte metabolism. Molecular
and Cellular Biology 22: 5989-5999.
32. Bennett, C.N., S.E. Ross, K.A. Longo, L. Bajnok,
N. Hemati, K.W. Johnson, S.D. Harrison, and O.A. MacDougald.
2002. Regulation of Wnt signaling during adipogenesis. Journal
of Biological Chemistry (in press).
33. Longo, K.A., J.A. Kennell, M.J. Ochocinska, S.E.
Ross, W.S. Wright, and O.A. MacDougald. 2002. Wnt signaling
protects 3T3-L1 preadipocytes from apoptosis through induction
of insulin-like growth factors. Journal of Biological Chemistry
(submitted).
34. Bennett, C.N., C. Hodge, O.A. MacDougald, and J. Schwartz.
2003. Role of Wnt10b and C/EBPa in Spontaneous Adipogenesis
of 243 Cells. Biochemical and Biophysical Research Communications
302: 12-16.
35. Kennell, J.A., E.E. O’Leary, B.M. Gummow, Gary D.
Hammer, and O.A. MacDougald. 2003. TCF-4N, a novel isoform
of mouse TCF-4, synergizes with b-catenin to coactivate
C/EBPa and SF-1 transcription factors. Molecular and Cellular
Biology 23: 5366-5375.
36. Ross, S.E., H.S. Radomska, F. Schaufele, P. Zhang,
J.N. Winnay, L. Bajnok, W.S. Wright, D.G. Tenen and O.A.
MacDougald. 2004. Phosphorylation of C/EBP inhibits granulopoiesis.
Molecular and Cellular Biology 24:675-686 .
37. Longo, K.A., W.S. Wright, S. Kang, I. Gerin, S.-H.
Chiang, P.C. Lucas, M.R. Opp, and O.A. MacDougald. 2004.
Wnt10b Inhibits Development of White and Brown Adipose Tissues.
Journal of Biological Chemistry 279: 35503-35509.
38. Vertino, A.M., J.M. Taylor-Jones, K.A. Longo, E.D. Bearden, T.F. Lane, R.E. McGehee, Jr., O.A. MacDougald, and C.A. Peterson. 2005 Wnt10b deficiency promotes coexpression of myogenic and adipogenic programs in myoblasts. Molecular Biology of the Cell. 16: 2039-2048.
39. Kang, S., L. Bajnok, K.A. Longo, R.K. Petersen, J.B. Hansen, K. Kristiansen, O.A. MacDougald. 2005. Effects of Wnt signaling on brown adipocyte differentiation and metabolism mediated by PGC-1a. Molecular and Cellular Biology 25: 1272-1282.
40. Gerin, I., V.W. Dolinsky, J.G. Shackman, R.T. Kennedy, S.-H. Chiang, C.F. Burant, K. Steffensen, J-Ä.Gustafsson, and O.A. MacDougald. 2005. LXRb is required for adipocyte growth, glucose homeostasis and b cell function in aged mice. Journal of Biological Chemistry 280: 23024-23031.
41. Bennett, C.N., K.A. Longo, W.S. Wright, L.J. Suva, T.F. Lane, K.D. Hankenson and O.A. MacDougald. 2005. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proceedings of the National Academy of Sciences 102: 3324-3329.
42. Kennell, J.A. and O.A. MacDougald. 2005. Wnt signaling inhibits adipogenesis through beta-catenin-dependent and -independent mechanisms. Journal of Biological Chemistry 25: 24004-24010.
43. Xu, Y., Y.L. Zhou, D.K Ann, O.A. MacDougald, L. Shum, M.L. and Snead. 2006. Transcription factor sumoylation and factor YY1 serve to modulate mouse amelogenin gene expression. European Journal of Oral Sciences 114: 201-202.
44. Xu, Y., Y.L. Zhou, W. Luo, Q.S Zhu, D. Levy, O.A. MacDougald, and M.L. Snead. 2006. NF-Y and CCAAT/enhancer-binding protein alpha synergistically activate the mouse amelogenin gene. The Journal of Biological Chemistry 281: 16090-16098.
45. Inoki, K. , H. Ouyang, T. Zhu, C. Lindvall, Y. Wang, X. Zhang, Q. Yang, C. Bennett, Y. Harada, K. Stankunas, C.Y. Wang, X. He, O.A. MacDougald, M. You, B.O. Williams, and K.L. Guan. 2006. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126: 955-968.
46. Qiao, L., O.A. MacDougald, and J. Shao. 2006. CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase. The Journal of Biological Chemistry 281: 24390-24397.
47. Wright, W.S., K.A. Longo, V.W. Dolinsky, I. Gerin, S. Kang, C.N. Bennett, S.H. Chiang, T.C. Prestwich, C. Gress, C.F. Burant, V.S. Susulic, and O.A. MacDougald. 2007. Wnt10b inhibits obesity in ob/ob and agouti mice. Diabetes 56: 295-303.
48. Xu, Y. Y.L. Zhou, O.A. MacDougald, and M.L. Snead. 2007. Physical dissection of the CCAAT/enhancer-binding protein a in regulating the mouse amelogenin gene. Biochemical and Biophysical Research Communications 354:56-61.
49. Datta, J. S. Majumder, H. Kutay, W. Frankel, R. Costa, H.C. Cha, O.A. MacDougald, S.T. Jacob, and K. Ghoshal. 2007. Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of C/EBPa by phosphatidyl inositol 3 kinase signaling cascade. Cancer Research 67: 2736-46.
50. Kang, S., C.N. Bennett, I. Gerin, L.A. Rapp, K.D. Hankenson, and O.A. MacDougald. 2007. Wnt Signaling Stimulates Osteoblastogenesis of Mesenchymal Precursors by Suppressing CCAAT/Enhancer-binding Protein {alpha} and Peroxisome Proliferator-activated Receptor {gamma}. The Journal of Biological Chemistry 282: 14515-14524.
51. Palpant, N.J., S.-I. Yasuda, O.A. MacDougald, and J.M. Metzger. 2007. Stromal vascular cells from mouse adipose tissue differentiate structurally and functionally into spontaneously beating myocytes containing developmental cardiac sarcomeric markers. Journal of Molecular and Cellular Cardiology (in press).
52. Aslanidi, G., G. Philipsberg, V. Kroutov, K. Lamb, E. Kohlbrenner, M. Campbell-Thompson, G. Walter, S. Kourenov, J.I. Aguirre, P. Keller, K.D. Hankenson, O.A. MacDougald, and S. Zolotukhin. 2007. Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats. American Journal of Physiology (in press).
53. Bommer, G.T., I. Gerin, Y. Feng, A.J. Kaczorowski, R. Kuick, R.E. Love, Y. Zhai, T.J. Giordano, Z.S. Qin, B.B. Moore, O.A. MacDougald, K.R. Cho, E.R. Fearon. p53-Mediated activation of miRNA34 candidate tumor suppressor genes. Current Biology (in press).
PUBLICATIONS – Reviews, Book chapters, New & Views, and Symposium Proceedings
1. Jump, D.B., G.J. Lepar, and O.A. MacDougald. 1992. Retinoic Acid Regulation of Gene Expression in Adipocytes. In: Nutrient Control of Gene Expression, (Eds. Berdiener, C. and J.L. Hargrove), CRC Press, Boca Raton, FL, pp 431-454.
2. Cornelius, P., O.A. MacDougald, and M.D. Lane. 1994. Regulation of Adipocyte Development. Annual Reviews of Nutrition. 14: 99-129.
3. MacDougald, O.A. and M.D. Lane. 1995. Transcriptional Regulation of Gene Expression During Adipocyte Differentiation. Annual Reviews of Biochemistry. 64: 345-373.
4. MacDougald, O.A. and M.D. Lane. 1995. When Precursors are also Regulators. Current Biology. 5: 618-621.
5. Lane, M.D., F.-T. Lin, O.A. MacDougald, and M.Vasseur-Cognet. 1996. Control of Adipocyte Differentiation by CCAAT/Enhancer Binding Proteina (C/EBPa). International Journal of Obesity and Related Metabolic Disorders. 20: S91-6 (Suppl. 3).
6. Darlington, G., S.E. Ross, and O.A. MacDougald. 1998. The Role of C/EBP Genes in Adipose Differentiation. Journal of Biological Chemistry. 273: 30057-30060.
7. Erickson, R.L., S.E. Ross, K.A. Longo, N. Hemati, and O.A. MacDougald. 2000. Structure and Function of C/EBPa. In Adipocyte Biology and Hormone Signaling (J.M. Ntambi; Ed.) IOS Press. pg. 79-90.
8. MacDougald, O.A. 2001. Signaling Pathway Puts the Break on Fat Cell Formation. TheScientificWorld. 1: 188-189.
9. MacDougald, O.A. and S. Mandrup. 2002. Adipogenesis: Forces that Tip the Scales. Trends in Endocrinology and Metabolism 13: 5-11.
10. Longo, K.A. and O.A. MacDougald. 2003. Wnt signaling in regulation of adipogenesis. In: Progress in Obesity Research: 9. Edited by G. Medeiros-Neto, A. Halpern and C. Bouchard. pp. 157-160.
11. Chiang, S.-H. and O.A. MacDougald. 2003. Will fatty worms help cure human obesity? Trends in Genetics 19: 523-525.
12. MacDougald, O.A. and C.F. Burant. 2005. News and Views: Fickle Factor Foils Fat Fate. Nature Cell Biology 7: 543-545.
13. MacDougald, O.A. and C.F. Burant. 2005. Commentary: Obesity and metabolic perturbations following loss of aquaporin 7, the adipose glycerol transporter. Proceedings of the National Academy of Sciences 102: 10759-10760.
14. Hall, C.L., S. Kang, O.A. MacDougald, and E.T. Keller. 2006. The role of Wnts in bone metastasis. J. Cellular Biochemistry 97: 661-672.
15. Gerin, I., H.C. Cha, and O.A. MacDougald. 2006. Regulation of adipocyte differentiation and metabolism by Wnt signaling and C/EBP transcription factors. In: New Transcription factors and their Roles in Diabetes and its Therapy. (J.E. Friedman, ed.), Advances in Molecular and Cellular Endocrinology 5:155-174. Elsevier, San Diego, CA.
16. Venkatesh, J., H.U. Bryant, and O.A. MacDougald. 2006. Regulation of bone mass by Wnt signaling. Journal of Clinical Investigation 116: 1202-1209.
17. E.D Rosen and MacDougald, O.A. 2006. Adipocyte differentiation from the inside out. Nature Reviews - Molecular and Cellular Biology 7: 885-896.
18. Kang, S., V. Dolinksy, and O.A. MacDougald. 2007. Will fatty worms or flies help discover the mechanism of human obesity? In: Genetics of Obesity. Ed. K. Clement and T. Sorensen. pp 143-156.
19. Prestwich, T.C., and O.A. MacDougald. 2007. Wnt/b-catenin signaling in adipogenesis and metabolism. Current Opinion in Cell Biology (in press).
