Microarray Data
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Wnt signaling maintains preadipocytes in an undifferentiated
state. When Wnt signaling is enforced, 3T3-L1 preadipocytes
no longer undergo adipocyte conversion in response
to adipogenic medium. Here we used microarray analyses
to identify subsets of genes whose expression is
aberrant when differentiation is blocked
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through enforced Wnt signaling. Furthermore, we
used the microarray data to identify potentially
important adipocyte genes and chose one of these,
the liver X receptor alpha (LXRalpha), for further
analyses.
read more
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In The News
Inhibiting Fat
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Genetically engineered mice,
created at the
UM Medical School, are living every dieter's
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| dream. They
eat unlimited amounts of high-fat mouse chow, but
have about 50 percent less body fat than normal
mice on a low-fat diet. And they show no signs of
diabetes or other metabolic disorders, which are
common in animals with too little fat. read more > |
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