Recent Reviews

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Barnett, P. Henk F. Tabak & Hettema E. H. Nuclear receptors arose from pre-existing protein modules during evolution, Trends in Biochemical Sciences, Volume 25, Issue 5, 1 May 2000, 227-228

de Kloet,  R. Onno, E. Meijer, C. Vreugdenhil, E &  JoŽls, M. The Yin and Yang of Nuclear Receptors: Symposium on Nuclear Receptors in Brain, Oegstgeest, The Netherlands, 13Į14 April 2000, Trends in Endocrinology and Metabolism, Volume 11, Issue 6, 1 August 2000, 245-248.

 

Egea, P.F. Klaholz, B.P. & Moras, D. Ligand-protein interactions in nuclear receptors of hormones, FEBS Letters, Volume 476, Issues 1-2, 30 June 2000, 62-67.

Fransoijs C.J.J.; Klomp J.P.G.; & Knegtel R.M.A. Sequence annotation of nuclear receptor ligand-binding domains by automated homology modeling, Protein Engineering, Volume 13, Issue 6, 2000, 391-394.

Giguere V. Orphan nuclear receptors: From gene to function, Endocrine Reviews, Volume 20, Issue 5, 1999, 689-725.

 

Klaholz B.P.; Mitschler A.; & Moras D. Structural basis for isotype selectivity of the human retinoic acid nuclear receptor, Journal of Molecular Biology, Volume 302, Issue 1, 8 September 2000, 155-170.

 

Kumar, R. & Thompson, B. The structure of the nuclear hormone receptors, Steroids, Volume 64, Issue 5, May, 1999, 310-319.

 

Martinez E.; Moore D.D.; Keller E.; Pearce D.; Vanden Heuvel J.P.; Robinson V.; Gottlieb B.; MacDonald P.; Simons S. Jr.; Sanchez E.; & Danielsen M. The Nuclear Receptor Resource: A growing family, Nucleic Acids Research, Volume 26, Issue 1, 1998, 239-241.

McKenna N.J.; Lanz R.B.; &  O'Malley B.W. Nuclear receptor coregulators: Cellular and molecular biology, Endocrine Reviews, Volume 20, Issue 3, 1999, 321-344.

 

Moras D.; Gronemeyer H. The nuclear receptor ligand-binding domain: Structure and function, Current Opinion in Cell Biology, Volume 10, Issue 3, 1998, 384-391.  

Poujol N.; Wurtz J.-M.; Tahiri B.; Lumbroso S.; Nicolas J.C.; Moras D.; & Sultan C. Specific recognition of androgens by their nuclear receptor: A structure-function study, Journal of Biological Chemistry, Volume 275, Issue 31, 4 August 2000, 24022-24031.

 

Weatherman R.V.; Fletterick R.J.; & Scanlan T.S. Nuclear-receptor ligands and ligand-binding domains, Annual Review of Biochemistry, Volume 68, 1999, 559-581.

 

Wurtz, J-M. & Gronemeyer, H. . A canonical structure for the ligand-binding domain of nuclear receptors, Nature Structural Biology, Volume 3, Issue 1, January,1996, 87-94. (Figure Correction, February, 1996, 206).

 

Receptor Specific Articles

 

Bourguet, W. Ruff, M. Chambon, P. Gronemeyer, H.  & Moras, D.. Crystal structure of the ligand-binding domain of human nuclear receptor RXR-alpha, Nature, Volume 375, 1 June, 1995, 377-382.

 

Brzozowksi, A.M. Pike, A.C. Dauter, Z. Hubbard, R. Bonn, T. Ennstrom, O. Ohman, L. Greene, G. Gustafasson, J-A, . & Calquist, M. Molecular basis of agonism and antagonism in the oestrogen receptor, Nature, Volume 389, 16 October, 1997, 753-758.

 

Fagart, J. Wurtz, J-M, Souque, A. Hellal-Levy, C. Moras, D. &  Raffestin-Oblin, M-E. Antagonism in the human mineralocorticoid receptor, The EMBO Journal, Volume 17, Issue 12, 1998, 3317ó3325.

 

Renaud, J-P. Rochel, N. Ruff, M. Vivat, V. Chambon, P. Gronemeyer, H. & Moras, D.. Crystal structure of the RAR-gamma ligand-binding domain bound to the all-trans retinoic acid, Nature, Volume 378,14 December, 1995, 681689.

Williams, S.P.  & Sigler, P.B. Atomic structure of progesterone complexed with its receptor, Nature, Volume 393, 28 May, 1998, 392-396.

 

Mueller-Fahrnow, A. &  Egner, U. Ligand-binding domain of estrogen receptors, Current Opinion in Biotechnology, Volume 10, 1999, 550-556.

 

Tanenbaum, D.M. Wang, Y. Williams, S.P. & Sigler, P. Crystallographic comparison of the estrogen and progesterone receptorís ligand binding domains, Proceedings of the National Academy of Sciences (US), Volume 95, Issue 11, 26 May, 1998, 5998-6003

 

Wurtz, J-M. & Gronemeyer, H. Three-Dimensional Models of Estrogen Receptor Ligand-Binding Domain Complexes, Based on Related Crystal Structures and Mutational and Structure-Activity Relationship Data, Journal of Medicinal Chemistry, , Volume 41 1998,  1803-1914.

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