by Larry P. Taylor, Ph. D.
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FGF Site: FGF Intro Nomenclature Notes References FGFR Sequences
This page: FGF Alignments Tree Sub-Families ( FGF 8 FGF 15 FGF 3 FGF 1 FGF 11 FGF 9 )
Human FGF Sequence Alignments
The amino acid sequences for human FGF (except FGF 15 which is from the mouse) were aligned with Clustal X. An explanation of Clustal X Colors and Symbols is at the bottom of the page.
Sub-Families ( FGF 8 FGF 15 FGF 3 FGF 1 FGF 11 FGF 9 )
The Clustal X sequence alignment for human FGF 1-23 (except FGF 15, which is only found in the mouse) is shown below:
FGF Alignments Sub-Families ( FGF 8 FGF 15 FGF 3 FGF 1 FGF 11 FGF 9 )
Tree View, based on the above sequence alignment, provides an evolutionary tree that attempts to trace each protein to a common ancestor protein. This tends to group the 23 FGF proteins into sub-families. Sub-family members, compared to the entire group, share higher sequence identity and structural characteristics.. This tree is shown below: Since these proteins converge to a single hypothetical evolutionary ancestor, these FGF proteins are homologous.
FGF Sub-Family Sequence Alignments
The sub-family alignments are presented in the order of the evolutionary tree:
FGF Alignments Tree Sub-Families ( FGF 15 FGF 3 FGF 1 FGF 11 FGF 9 )
FGF Alignments Tree Sub-Families ( FGF 8 FGF 3 FGF 1 FGF 11 FGF 9 )
FGF Alignments Tree Sub-Families ( FGF 8 FGF 15 FGF 1 FGF 11 FGF 9 )
FGF Alignments Tree Sub-Families ( FGF 8 FGF 15 FGF 3 FGF 11 FGF 9 )
FGF Alignments Tree Sub-Families ( FGF 8 FGF 15 FGF 3 FGF 1 FGF 9 )
FGF Alignments Tree Sub-Families ( FGF 8 FGF 15 FGF 3 FGF 1 FGF 11)
Clustal X does a consensus analysis for each column in the alignment. Underneath the alignment is a plot for the quality of conservation; the higher this plot, the better than conservation. In addition, above each column is a symbol denoting conservation type. The symbols are:
* indicates positions which have a single, fully conserved
residue.
: indicates that one of the following 'strong' groups is
fully conserved: STA, NEQK, NHQK, NDEQ, QHRK, MILV, MILF, HY, FYW.
. indicates that one of the following 'weaker' groups is
fully conserved: CSA, ATV, SAG, STNK, STPA, SGND, SNDEQK, NDEQHK, NEQHRK, FVLIM,
HFY.
The coloring scheme for the amino acid residues is
Cyan = A, F, I, L, M, V, W (small, and/or hydrophobic)
Gray = H, Y
Green = N, Q, S, T (neutral & polar)
Magenta = D, E, R
Orange = G
Red = C, K
Yellow = P
This page: FGF Alignments Tree Sub-Families ( FGF 8 FGF 15 FGF 3 FGF 1 FGF 11 FGF 9 )
FGF Site: FGF Intro Nomenclature Notes References FGFR Sequences
My University Home Harris Links Chemistry / Modeling Links
Copyright 2005-2020 by Larry P. Taylor
Molecular &
Behavioral Neuroscience Institute
University of Michigan
All Rights Reserved
Supported by the Pritzker Neuropsychiatric Disorders Research Consortium, and by NIH Grant 5 P01 MH42251, Conte Center Grant #L99MH60398, RO1 DA13386 and the Office of Naval Research (ONR) N00014-02-1-0879 to Huda Akil & Stanley J. Watson. at the Molecular & Behavioral Neuroscience Institute.