Child-Neuro:

Research Protocols Seeking Patients

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• Cerebral Palsy
  • Hyperbaric oxygen (Lacey, Dayton; listed 8/06)

• Cerebrovascular disease

  • Study of abnormal blood clotting in children with stroke (Lynch, NINDS; listed 7/06)
  • Database for stroke in infants and children (deVeber, Toronto; Lynch, NINDS, listed 7/06)

• Epilepsy

  • Pyridoxine-dependent seizures (Gospe; University of Washington; listed 8/06) 
  • Genetics of Rolandic epilepsy (Pal; Columbia Univ. School of Public Health; listed 8/06)
  • Attention impairment and childhood absence epilepsy (Blumenfeld; Yale; listed 1/07)
  • Randomized, Controlled Trial of Ganaxolone in Patients With Infantile Spasms (Multicenter; Mitchell, Children's Hospital of Los Angeles and other sites; listed 5/07)
  • Clobazam in Patients With Lennox-Gastaut Syndrome (Multicenter; Mitchell, Children's Hospital of Los Angeles and other sites; listed 11/07)
  • Diazepam Injection (Vanquix-TM) for Acute Repetitive Seizures (Multicenter;Mintz, Clinical Research Center of New Jersey; listed 11/07)

• Headaches

  • Atkins Diet for chronic daily headaches (Kassoff, Hopkins; listed 8/06)
  • Long-Term Safety of Trexima (combination naproxen sodium and
    sumatriptan succinate) for Migraine in Adolescents (Multicenter; Mintz, Clinical Research Center of New Jersey; listed 11/07)

• Infectious diseases

• Malformations

  • Holoprosencephaly (Carter Centers; listed 7/06)
  • Migrational defects (Walsh; Harvard; listed 7/06)
  • Agenesis of the corpus callosum (Sherr; UCSF; list 8/06)

• Metabolic, genetic, and miscellaneous

  • Neurodegeneration with brain iron accumulation (NBIA), including pantothenate kinase-associated neurodegeneration (PKAN) and infantile neuroaxonal dystrophy (INAD) (Hayflick; Oregon; listed 7/06)
  • Rett syndrome pathogenesis (Naidu, Hopkins; listed 10/06)
  • Rett syndrome olfactory receptor neuron model (Naidu, Hopkins; listed 10/06)
  • Rett syndrome dextromethorphan trial (Naidu, Hopkins; listed 10/06)
  • Gene expression and genetic mental retardation (Kaufmann, Hopkins; listed 11/06)
  • Clinical and immunological investigation of subtypes of autism (Swedo, NIH; listed 2/07)
  • Minocycline to treat childhood regressive autism (Neville and Swedo, NIH; listed 2/07)

• Movement disorders

• Multiple sclerosis and related disorders

  • Pediatrics Multiple Sclerosis Centers (listed 7/06)
  • Iranian childhood multiple sclerosis study (Rad, Iran; listed 7/06)

• Neurocutaneous

  • Tuberous sclerosis twin study (Kwiatkowski, Harvard; listed 7/06)
  • Atkins Diet for SturgeWeber syndrome (Kassoff, Hopkins; listed 8/06)

• Neuromuscular

  • Families with siblings discordant for systemic rheumatic disorders (including myositis) (Rider, NIH; listed 7/06)
  • Extraocular muscle research (Engle; Harvard; listed 7/06)
  • Fukutin-related protein (FKRP) muscular dystrophy (Matthews, Iowa; listed 8/06)
  • Rituximab in the Treatment of Myositis (RIM) (Multicenter; Oddis, Pittsburgh, and Reed, Mayo; listed 5/07)

• Tumors

   

  To have your study listed here, send a description along with the primary investigator's name, address, phone #, fax, and email address to Steve Leber at Leber at med.umich.edu. We ask that all posted studies involving patients have approval from their local Institutional Review Boards, but we have not asked for confirmation.

  The initial listings here were taken from the brief descriptions included on the monthly Child-Neuro listserv mailing. If you'd like to send a longer description, I'd be happy to include it.

  See also:
  

• ClinicalTrials.gov, the NIH's official clinical trials list, provides regularly updated information about federally and privately supported clinical research in human volunteers.
• CenterWatch Clinical Trials Listing Service A searchable international listing of clinical research trials. Presents drug therapies newly approved by the Food and Drug Administration.

• The journal Neurology's Clinical Trials Recruiting Page

• OncoLink Clinical Trials from the National Cancer Institute and University of Pennsylvania, including brain tumor protocols.

Last revised 01-May-2008 by Steven Leber