CTs showing calcifications in the periventricular and callosal, as well as in areas adjacent to the white matter abnormalities.
Coronal T2 MRI showing white matter changes and presumed Wallerian degeneration in the right corticospinal tract.
Axial FLAIR MRI showing predominantly posterior abnormalities. There is no enhancing rim (not shown). There are patchy areas of increased callosal signal, but these do not show up well in this scan.
The sister's CTs look almost identical. The MRI changes are milder with more symmetric and predominantly periventricular abnormalities.