Our research is at the intersection of Chemistry, Physics and Biology. We ask questions that will help us to learn the basic design and functional principles behind the structure and function of biological molecules and chemical reactions. Ultimately we would like to know why nature has chosen to shape her structures the way she has. "Why" questions, however, are very difficult to address, so we will begin by investigating how proteins work, how they interact with their surroundings, and how they interact with other proteins. This understanding would put us in a very powerful position to design, alter and manipulate chemical structure and reactivity in a rational way. Embedded within a broader context of structural biology, we might see the day where drug design and bioengineering are truly based on microscopic molecular foundations.