Jeffrey Sean Huo

e-mail (primary): jeffshuo@umich.edu
e-mail (alternate/permanent): jeffshuo@alumni.northwestern.edu



Current Work

I am currently a resident in Pediatrics at Washington University in St. Louis School of Medicine.

I will be beginning a fellowship in Pediatric Hematology/Oncology in 2010 at Johns Hopkins / NIH - National Cancer Institute.

I did my PhD work at the University of Michigan Medical School Medical Scientist Training Program (MD/PhD). My thesis research explored the molecular mechanisms by which growth hormone regulates age-associated changes in gene expression with work in the laboratories of Jessica Schwartz, Ph.D. and Kotoku Kurachi, Ph.D..

Previous research work was with Dr. David Mogul, Ph.D., Biomedical Engineering Department, Northwestern University, exploring hippocampal electrophysiology.

I spent a year on the Pediatric Hematology/Oncology clinic of Laurence A Boxer , M.D..



Education

University of Michigan, Ann Arbor, MI
M.D. With Distinction in Research; With Distinction in Service, Medical School, 2007
Ph.D., Cellular and Molecular Biology Program, 2005

Northwestern University, Evanston, IL
B.S. (Magna Cum Laude), Biomedical Engineering, 1997




Publications
• Chen, Y. Lin, G. Huo, JS. Barney, D. Wang, Z. Livshiz, T. States, DJ. Qin, ZS. Schwartz, J. Computational and functional analysis of growth hormone-regulated genes identifies the transcriptional repressor Bcl6 as a participant in GH-regulated transcription. Endocrinology, accepted for publication. 2009.

• Kurachi, S. Huo, JS. Ameri, A. Zhang, K. Yoshizawa, AC. Kurachi, K. An age related homeostasis mechanism is essential for spontaneous amelioration of hemophilia B Leyden. PNAS, accepted for publication. 2009.

• Chen L, Maures TJ, Jin H, Huo JS, Rabbani SA, Schwartz J, Carter-Su C. SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10. Mol Endocrinol. 22(2) 454-76. 2008.

  Huo JS, McEachin RC, Cui TX, Duggal NK, Hai T, States DJ, Schwartz J. Profiles of growth hormone (GH)-regulated genes reveal time-dependent responses and identify a mechanism for regulation of activating transcription factor 3 by GH. JBC 281(7):4132-41. 2006.

• Schwartz, J. Huo, JS. Piwien-Pilipuk, G. Growth Hormone Regulated Gene Expression. Minerva Endocrinol. 4:231-41. 2002.

• Kurachi, K. Zhang, K. Huo, J. Ameri, A. Kuwahara, M. Fontaine, JM. Yamamoto, K. Kurachi, S. Age-related Regulation of Genes: Slow Homeostatic Changes and Age-Dimension Technology. Physica A. 315:1-5-113. 2002.

• Piwien-Pilipuk, G. Huo, JS. Schwartz, J. Growth Hormone Signal Transduction. J. Pediatric Endocrinology Metabolism 15:771-86. 2002.

• Kurachi, S. Ameri, A. Huo, J. Hoff, J. Atoda, H. Kurachi, K. Specific gene expression switches are responsible for puberty-onset amelioration of transgenic mouse Leyden: construction of transgenic mouse models and role of growth hormone. Blood 96: (11) 2107, Part 1. 2000. (Abstract)

• Kurachi, K. Zhang KZ. Ameri, A. Huo, J. Atoda, H. Kurachi, S. IUBUMB Life 49(3):189-196.
  

• Kurachi, S. Ameri, A. Huo, J. Pantazatos, D. Hoff, J. Kurachi, K. Blood 94(10):455A Part 1. Suppl 1.
  

• Acknowledgment in Kurachi, S. Deyashiki, Y. Takeshita, L. Kurachi, K. Science 285(5428):739-743.
  


Fellowships and Scholarships (selected)
• Winner, 2001 NSF Graduate Research Fellowship
• Winner, 2001 National Defense Science and Engineering Graduate Fellowship
• Alternate, 2001 Howard Hughes Medical Institute Pre-doctoral Fellowship
• Winner, 1999 Howard Hughes Medical Institute Medical Student Research Training Fellowship
• University of Michigan Medical School Merit Scholarship, 1997

Honors and Awards (selected)
• U. Michigan Cardiovascular Research Symposium Poster Award (2 / 20+ presenters), 2000
• Departmental Honors (Biomedical Engineering), 1997
• Tau Beta Pi National Engineering Honor Society, 1997
• Mortar Board National Honor Society, 1996
• Golden Key National Honor Society, 1996
• Dean's List, Northwestern University (6/9 quarters, one with high honors)


Supplemental information available in a full CV here.


Personal Information
I was born in Royal Oak, Michigan, and previously lived in the suburbs of Detroit and Rochester, NY before my family was transferred to Japan by my father's corporation, General Motors. My family has since returned to Michigan and now live near a lake near Fenton, MI.

My personal home page can be found here.





May 15th, 2009