Jeffrey Sean Huo MD PhD

    e-mail (primary):
    e-mail (alternate/permanent):

    Current Work

    Research and Professional Interests


    Board Certification

      General Pediatrics, American Board of Pediatrics, 2011
      Pediatric Hematology/Oncology, American Board of Pediatrics, 2015


    • Roca, H. Pande, M. Huo, JS. Hernandez, J. Cavalcoli, JD. Pienta, KJ. McEachin, RC. A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial - mesenchymal cell reprogramming and cancer progression. BMC Systems Biology. In press.

    • Park, TS. Bhutto, I. Zimmerlin, L. Huo, JS. Nagaria P. Miller, D. Rufaihah, AJ. Talbot, C. Aguilar, J. Grebe, R. Merges, C. Reijo-Pera, R. Feldman, RA. Rassool, F. Cooke, J. Lutty, G. Zambidis, ET. Vascular Progenitors from Cord Blood-Derived iPSC Possess Augmented Capacity for Regenerating Ischemic Retinal Vasculature. Circulation. 129(3):359-72. 2014. PMCID 24163065.

    • Huo, JS. Zambidis, ET. Pivots of pluripotency: The roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells. Biochimica Biophysica Acta. 1830(2):2385-94. 2013. PMCID 23104383.

    • Park, TS. Huo, JS. Peters, A. Talbot, CC. Verma, K. Zimmerlin, L. Kaplan, IM. Zambidis, ET. Growth factor-activated stem cell circuits and stromal signals cooperatively accelerate non-integrated iPSC reprogramming of human myeloid progenitors. PLoS One. 7(8):e42838. 2012. PMCID 22905176.

    • Kurachi, S. Huo, JS. Ameri, A. Zhang, K. Yoshizawa, A. Kurachi, K. An age-related homeostasis mechanism is essential spontaneous amelioration of hemophilia B Leyden. Proc Natl Acad Sci U S A. 106(19):7921-6. 2009. PMCID 19416882.

    • Chen Y, Lin G, Huo, JS. Barney D, Wang Z, Livshiz T, States DJ, Qin ZS, Schwartz J. Computational and functional analysis of growth hormone-regulated genes identifies the transcriptional repressor Bcl6 as a participant in GH-regulated transcription. Endocrinology. 150(8):3645-54. 2009. PMCID 19406940.

    • Watkins, MG. Dejkhamron, P. Huo, J. Vazquez, DM. Menon, RK. Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. Endocr Pract. 14(4): 479-83. 2008. PMCID 18558604.

    • Chen, L. Maures, TJ. Jin, H. Huo, JS. Rabbani, SA. Schwartz, J. Carter-Su, C. SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10. Mol Endocrinol. 22(2): 454-76. 2008. PMCID 17947375.

    • Huo, JS. McEachin, RC. Duggal, NK. Hai, T. States, DJ. Schwartz, J. Profiles of Growth Hormone-Regulated Genes Identify a Role for C/EBPb in Expression of ATF3. J. Biological Chemistry 281: 4132-4141, 2006. PMCID 16326703.

    • Cui, TX. Piwien-Pilipuk, G. Huo, JS. Kaplani, JI. Kwok R. Schwartz, J. Endogenous C/EBPb and p300 are Dynamically Regulated by Growth Hormone. Mol. Endocrinol. 19:2175-86. 2005. PMCID 15860545.

    • Schwartz, J. Huo, JS. Piwien-Pilipuk, G. Growth Hormone Regulated Gene Expression. Minerva Endocrinol. 4:231-41. 2002.

    • Kurachi, K. Zhang, K. Huo, J. Ameri, A. Kuwahara, M. Fontaine, JM. Yamamoto, K. Kurachi, S. Age-related Regulation of Genes: Slow Homeostatic Changes and Age-Dimension Technology. Physica A. 315:1-5-113. 2002.

    • Piwien-Pilipuk, G. Huo, JS. Schwartz, J. Growth Hormone Signal Transduction. J. Pediatric Endocrinology Metabolism 15:771-86. 2002.

    • Kurachi, S. Ameri, A. Huo, J. Hoff, J. Atoda, H. Kurachi, K. Specific gene expression switches are responsible for puberty-onset amelioration of transgenic mouse Leyden: construction of transgenic mouse models and role of growth hormone. Blood 96: (11) 2107, Part 1. 2000. (Abstract)

    • Kurachi, K. Zhang KZ. Ameri, A. Huo, J. Atoda, H. Kurachi, S. IUBUMB Life 49(3):189-196.

    • Kurachi, S. Ameri, A. Huo, J. Pantazatos, D. Hoff, J. Kurachi, K. Blood 94(10):455A Part 1. Suppl 1.

    • Acknowledgment in Kurachi, S. Deyashiki, Y. Takeshita, L. Kurachi, K. Science 285(5428):739-743.

    Fellowships and Scholarships (selected)

    Honors and Awards (selected)

    • NIH Pediatric Oncology Branch Research Day - Poster Award (4 / 40+ presenters), 2013
    • U. Michigan Medical Center Alumni Society 3rd Year Student Service Award ( 1 / class), 2006
    • U. Michigan Cardiovascular Research Symposium Poster Award (2 / 20+ presenters), 2000
    • Departmental Honors (Biomedical Engineering), 1997
    • Tau Beta Pi National Engineering Honor Society, 1997
    • Mortar Board National Honor Society, 1996
    • Golden Key National Honor Society, 1996
    • Dean's List, Northwestern University (6/9 quarters, one with high honors)

    Personal Information

      I was born in Royal Oak, Michigan, and previously lived in the suburbs of Detroit and Rochester, NY before my family was transferred to Japan by my father's corporation, General Motors. My family has since returned to Michigan and now live near a lake near Fenton, MI.

      My personal home page can be found here.

    May 12th, 2015

All materials copyright Jeffrey Huo, 2003