Index List of Apoptosis Regulator All-in-One Seq Analyzer
Inohara, Naohiro, PhD
猪原直弘Research Associate Professor
Department of Pathology, University of Michigan Medical School
Address
1500 E. Medical Center Dr., Ann Arbor, MI 48109
MSRBII C574E-mail address: ino@umich.edu
Born in Japan on 1963.
Educated in Shizuoka University (1982-1986) and Osaka University (1986-1991), PhD
Jichi Medical School (1991-1994), Nippon Medical School (1995-1996)
Postdoctoral fellow (1996-1998) and Research fellow (1998) in G. Nunez lab. of University of Michigan (UM)
Assistant Research Scientist (1998-2004) in UM
Research Associate Professor (2004-present) in UM (Department of Pathology)
Professor (2007-2008) in University of Yamanashi (Department of Biochemistry II)
(Alternative List
also available in NCBI)
(*, The authors contributed equally to the work)
Dowds TA, Masumoto J, Zhu L, Inohara N, Nunez G
Cryopyrin induced IL-1neta secretion in monocytic cells: Enhanced activity of disease-associated mutants and requirement for ASC
J Biol Chem. 2004 279: 21924-21928.
Imaizumi K, Benito A, Kiryu-Seo S, Gonzalez V, Inohara N, Leiberman AP, Kiyama H, Nunez G.
Critical role for DP5/Harakiri, a Bcl-2 homology domain 3-only Bcl-2 family member, in axotomy-induced neuronal cell death.
J Neurosci. 2004 Apr 14;24(15):3721-5.
Tanabe T, Chamaillard M, Ogura Y, Zhu L, Qiu S, Masumoto J, Ghosh P, Moran A, Predergast MM, Tromp G, Williams CJ, Inohara N**, Nunez G**.
Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition.
EMBO J. 2004 Apr 7;23(7):1587-1597.
Tang ED, Inohara N, Wang CY, Nunez G, Guan KL.
Roles for homotypic interactions and transautophosphorylation in IKKbeta activation.
J Biol Chem. 2003 278(40):38566-38570.Chamaillard M, Hashimoto M, Horie Y, Masumoto J, Qiu S, Saab L, Ogura Y, Kawasaki A, Fukase K, Kusumoto S, Valvano MA, Foster SJ, Mak TW, Nunez G, Inohara N.
An Essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid.
Nat Immunol. 2003 Jul;4(7):702-707.Ogura Y, Saab L, Chen FF, Benito A, Inohara N, Nunez G.
Genetic variation and activity of mouse Nod2, a susceptibility gene for Crohn's disease small star, filled.
Genomics. 2003 Apr;81(4):369-77.Masumoto J, Dowds TA, Schaner P, Chen FF, Ogura Y, Li M, Zhu L, Katsuyama T, Sagara J, Tanigichi S, Gumucio DL, Nunez G, Inohara N.
ASC is an activating adaptor for NF-kappaB and caspase-8-dependent apoptosis.
Biochem Biopys Res Com 303, 69-73 (2003)Dowds TA, Masumoto J, Chen FF, Ogura Y, Inohara N**, Nunez G**.
Regulation of cryopyrin/Pypaf1 signaling by pyrin, the familial Mediterranean fever gene product
Biochem Biophys Res Com 302, 575-580 (2003).Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S, Kusumoto S, Hashimoto M, Foster SJ, Moran AP, Fernandez-Luna JL, Nunez G.
Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn's disease
J Biol Chem. 2003 Feb 21;278(8):5509-5512.Jimbo A, Fujita E, Kouroku Y, Ohnishi J, Inohara N, Kuida K, Sakamaki K, Yonehara S, Momoi T.
ER stress induces caspase-8 activation, stimulating cytochrome c release and caspase-9 activation.
Exp Cell Res 2003 Feb 15;283(2):156-66Masumoto J, Zhou W, Chen FF, Su F, Kuwada JY, Hidaka E, Katsuyama T, Sagara J, Taniguchi S, Ngo-Hazelett P, Postlethwait JH, Nunez G, Inohara N.
Caspy: A Zebrafish caspase activated by ASC oligomerization required for pharyngeal Arch development.
J Biol Chem 2003 Feb 7;278(6):4268-76Bonen DK, Ogura Y, Nicolae DL, Inohara N, Saab L, Tanabe T, Chen FF, Foster SJ, Duerr RH, Brant SR, Cho JH, Nunez G.
Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan.
Gastroenterology 2003 Jan;124(1):140-146
Wang X, Kuivaniemi H, Bonavita G, Mutkus L, Mau U, Blau E, Inohara N, Nunez G, Tromp G, Williams CJ.
CARD15 mutations in familial granulomatosis syndromes: A study of the original Blau syndrome kindred and other families with large-vessel arteritis and cranial neuropathy.
Arthritis Rheum 2002 Nov;46(11):3041-5Gutierrez O, Pipaon C, Inohara N, Fontalba A, Ogura Y, Prosper F, Nunez G, Fernandez-Luna JL.
Induction of Nod2 in myelomonocytic and intestinal Epithelial cellsvia nuclear factor-kB activation.
J Biol Chem. 2002 Nov 1;277(44):41701-5Muto A, Ruland J, McAllister-Lucas LM, Lucas PC, Lic Q, Verma PM, Yamaoka S, Chen FF, Mak TW, Nunez G and Inohara N
PKK mediates Bcl10-independent NF-kB Activation Induced by Phorbol Ester.
J Biol Chem 2002 Aug 30;277(35):31871-6Inoue N, Tamura K, Kinouchi Y, Fukuda Y, Takahashi S, Ogura Y, Inohara N, Nunez G, Kishi Y, Koike Y, Shimosegawa T, Shimoyama T, Hibi T (2002)
Lack of Common NOD2 Variants in Japanese Patients With Crohn's Disease
Gasteroenterology 123: 86-91 (2002)Kobayashi K, Inohara N, Hernandez LD, Galan JE, Nunez G, Janeway CA, Medzhitov R, Flavell RA (2002)
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
Nature 416, 194 - 199 (2002)
Nair RP, Stuart P, Ogura Y, Inohara N, Chia NVC, Young L, Henseler T, Jenisch S, Christophers E, Voorhees JJ, Nunez G, Elder JT (2001)
Lack of association between NOD2 3020InsC frameshift mutation and psoriasis.
J Invest Dematol 117, 1671-1672McAllister-Lucas LM*, Inohara N*, Lucas PC*, Ruland J, Li Q, Chen S, Chen FF, Yamaoka S, Verma IM, Mak TW, Nunez G. (2001)
Bimp1, a MAGUK family member linking PKC activation to Bcl10-mediated NF-kappaB induction.
J Biol Chem 276, 30589-30597Ogura Y, Bonen, DK, Inohara N, Nicolae DL, Chen F, Ramos R, Britton H, Moran T, Karaliuskas R, Duerr RH, Achkar JP, Brant SR, Bayless TM, Kirschner BS, Hanauer SB, Nunez G, Cho JH. (2001)
Susceptibility to Crohn's disease by a frameshift mutation in nod2, resulting in lipopolysaccharide hyporesponsiveness.
Nature 411, 603-606Lucas PC, Yonezumi M, Inohara N, McAllister-Lucas LM, Abazeed ME, Chen FF, Yamaoka S, Seto M, Nunez G. (2001)
Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma,cooperate in a novel NF-kappaB signaling pathway
J.Biol. Chem. 276,19012-19019Nickerson K*, Sisk TJ*, Inohara N*, Yee CSK, Kennell J, Cho M-C, Yannie PJ, Nunez G, Chang C-H (2000)
Dendritic cell specific CIITA contains a caspase-recruitment domain that confers potent transactivation activity.
J. Biol. Chem. 276, 19089-19093Ogura Y, Inohara N, Benito A, Chen, FF, Yamaoka S, Nunez G. (2001)
Nod2, a Nod1/Apaf-1 family member that is restincted to monocytes and activates NF-kappaB
J. Biol. Chem. 276: 4812-4818Inohara N, Ogura Y, Chen FF, Muto A, Nunez G. (2001)
Human Nod1 Confers Responsiveness to Bacterial Lipopolysaccharides.
J. Biol. Chem. 276, 2551-2554
Inohara N, Koseki T, Lin J, del Peso L, Lucas PC, Chen FF, Ogura Y, Nunez G.
An induced proximity model for NF-kappaB activation in the Nod1/RICK and RIP signaling pathways
J Biol Chem. 2000 275:27823-27831del Peso,L., Gonzalez, V.M., Inohara, N., Ellis, R.E., Nunez, G. (2000)
Disruption of the CED-9/CED-4 Complex by EGL-1 is a Critical Step for Programmed Cell Death in C. elegans
J. Biol. Chem. 2000 275: 27205-27211Odajima J, Matsumura I, Sonoyama J, Daino H, Kawasaki A, Tanaka H, Inohara N, Kitamura T, Downward J, Nakajima K, Hirano T, Kanakura Y (2000)
Full Oncogenic Activities of v-Src are Mediated by Multiple Signaling Pathways; Ras as an Essential Mediator for Cell Survival.
J Biol Chem 2000 275(31):24096-24105Inohara, N., Nunuez, G. (2000)
Genes with homology to mammalian apoptosis regulators identified in zebrafish.
Cell Death and Differ. 7, 509-510 [direct link]Sanz, C., Benito, A., Inohara, N., Ekhterae, D., Nunez, G., Fernandez-Luna, J.L. (2000)
Specific and rapid induction of the proapoptotic protein Hrk after growth factor withdrawal in hematopoietic progenitor cells
Blood 95, 2742-2747.Benedict, MA, Hu, Y, Inohara, N, Nunez,G (2000)
Expression and functional analysis of Apaf-1 isoforms. Extra WD-40 repeat is required for cytochrome c binding and regulated activation of procaspase-9.
J. Biol. Chem. 275, 8461-8468Igaki, T., Kanuka, H., Inohara, N., Sawamoto, K., Nunez, G., Okano, H., Miura, M. (2000)
Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death.
Proc. Natl. Acad. Sci. USA. 97, 662-667.
Kanuka, H., Sawamoto, K., Inohara, N., Matsuno, K., Okano, H., & Miura, M.
Control of the Cell Death Pathway by Dapaf-1, a Drosophila Apaf-1/CED-4-Related Caspase Activator
Mol. Cell 1999 4:757-769. [direct link]Inohara, N. & Nunez, G.
Genes with homology to DFF/CIDEs found in Drosophila melanogaster
Cell Death Differ. 1999 6(9):711-721. [direct link]Inohara, N., Koseki, T., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, Liu, D., Ni, J. & Nunez, G.
Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-{kappa}B
J. Biol. Chem. 1999 May 21 274(21). 14560-14568Koseki, T., Inohara, N., Chen, S., Carrio, R., Merino, J., Hottiger, M.O., Nabel, G.J., & Nunez, G.
CIPER, a novel NF-{kappa}B-activating protein containing a caspase recruitment domain with homology to Herpesvirus-2 protein E10
J. Biol. Chem. 1999 Apr 9 274(15). 9955-9962Inohara, N., Koseki,T., Chen, S., Benedict, MA, & Nunez, G.
Identification of regulatory and catalytic domains in the apoptosis nuclease DFF40/CAD
J. Biol. Chem. 1999 Jan 1 274(1). 270-274
Inohara, N., Gourley, T.S., Carrio, R., Muniz, M., Merino, J., Garcia, I., Koseki, T., Hu, Y., Chen, S., & Nunez, G.
Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death.
J. Biol. Chem. 1998 Dec 4 273(49). 32479-32486Inohara, N., del Peso, L., Koseki, T., Chen, S., & Nunez, G.
RICK, a Novel Protein Kinase Containing a Caspase Recruitment Domain, Interacts with CLARP and Regulates CD95-mediated Apoptosis.
J Biol Chem 1998 May 15;273(20):12296-12300Inohara, N., Koseki, T., Chen, S., Wu, X., & Nunez, G.
CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor.
EMBO J 1998 May 1;17(9):2526-2533Koseki, T., Inohara, N., Chen, S., & Nunez, G.
ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases.
Proc Natl Acad Sci U S A 1998 Apr 28;95(9):5156-5160Hu, Y., Benedict, M.A., Wu, D., Inohara, N., & Nunez, G.
Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation.
Proc Natl Acad Sci U S A 1998 Apr 14;95(8):4386-4391Inohara, N., Ekhterae, D., Garcia, I., Carrio, R., Merino, J., Merry, A., Chen, S., & Nunez, G.
Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL.
J Biol Chem 1998 Apr 10;273(15):8705-8710
Aritomi, M., Kunishima, N., Inohara, N., Ishibashi, Y., Ohta, S., & Morikawa, K.
Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family.
J Biol Chem 1997 Oct 31;272(44):27886-27892Inohara N, Koseki T, Hu Y, Chen S, & Nunez G
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis.
Proc Natl Acad Sci U S A 1997 Sep 30;94(20):10717-10722Wu D, Wallen HD, Inohara N, & Nunez G
Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9.
J Biol Chem 1997 Aug 22;272(34):21449-21454Grillot DA, Gonzalez-Garcia M, Ekhterae D, Duan L, Inohara N, Ohta S, Seldin MF, & Nunez G.
Genomic organization, promoter region analysis, and chromosome localization
of the mouse bcl-x gene.
J Immunol 1997 May 15;158(10):4750-4757Inohara N, Ding L, Chen S, Nunez G
harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L).
EMBO J 1997 Apr 1;16(7):1686-1694
Shiraiwa N, Inohara N, Okada S, Yuzaki M, Shoji S, Ohta S
An additional form of rat Bcl-x, Bcl-xbeta, generated by an unspliced RNA, promotes apoptosis in promyeloid cells.
J Biol Chem 1996 May 31;271(22):13258-13265Uenaka R, Kuwajima M, Ono A, Matsuzawa Y, Hayakawa J, Inohara N, Kagawa Y, Ohta S
Increased expression of carnitine palmitoyltransferase I gene is repressed by administering L-carnitine in the hearts of carnitine-deficient juvenile visceral steatosis mice.
J Biochem (Tokyo) 1996 Mar;119(3):533-540
Koike T*, Inohara N*, Sato I, Tamada T, Kagawa Y, Ohta S
Transcription of the MRP RNA gene in frog stage I oocytes requires a novel cis-element.
Biochem Biophys Res Commun 1994 Jul 15;202(1):225-233Akiyama S, Endo H, Inohara N, Ohta S, Kagawa Y
Gene structure and cell type-specific expression of the human ATP synthase alpha subunit.
Biochim Biophys Acta 1994 Sep 13;1219(1):129-140
Shimomura S, Liu W, Inohara N, Watanabe S, Futai M
Structure of the gene for an auxin-binding protein and a gene for 7SL RNA from Arabidopsis thaliana.
Plant Cell Physiol 1993 Jun;34(4):633-637Inohara N, Iwamoto A, Moriyama Y, Shimomura S, Maeda M, Futai M
Two genes, atpC1 and atpC2, for the gamma subunit of Arabidopsis thaliana chloroplast ATP synthase.
J Biol Chem 1991 Apr 25;266(12):7333-7338Inohara, N., Shimomura, S., Fukui, T., Futai, M.
Auxin-binding protein located in the endoplasmic reticulum of maize shoots: molecular cloning and complete primary structure.
Proc Natl Acad Sci U S A 1989 May;86(10):3564-3568Shimomura S., Inohara N., Fukui, T., Futai, M. Different properties of two types of auxin-binding sites in membranes from coleoptiles.
Planta. 1988 157, 558-566
Yamada, S., Fujii, J., Inohara, N. Characterization of basic ATPase of fragmented sercoplasmic reticulum isolated from rabbit skeltal muscle.
Reports of Faculty of Science, Shizuoka University 1987 21, 89-99
Review
McDonald C, Inohara N, Nunez G.
Peptidoglycan Signaling in Innate Immunity and Inflammatory Disease.
J Biol Chem. 2005 May 27;280(21):20177-80
Inohara N, Chamaillard M, McDonald C, Nunez G.
NOD-LRR Proteins: Role in Host-Microbial Interactions and Inflammatory Disease.
Annu Rev Biochem. 2005;74:355-83
Chamaillard M, Inohara N, Nunez G.
Battling enteroinvasive bacteria: Nod1 comes to the rescue.
Trends Microbiol. 2004 Dec;12(12):529-32.
Inohara N, Nunez G.
NODS: Intracellar proteins involved in inflammation and apoptosis.
Nat Rev Immunol 3, 371-382Inohara N, Ogura Y, Nunez G.
Nods: a family of cytosolic proteins that regulate the host response to pathogens.
Curr Opin Microbiol. 2002 5, 76-80.
Inohara N, Nunez G.
ML- a conserved domain involved in innate immunity and lipid metabolism
Trends Biochem Sci 2002 27, 219-221Inohara N, Nunez G.
The NOD: a signaling module that regulates apoptosis and host defense against pathogens.
Oncogene 2001 Oct 1;20(44):6473-81Nunez, G., Benedict, M.A., Hu, Y., Inohara, N.
Caspases: The proteases of the apoptotic pathway.
Oncogene 1998 Dec 24;17(25):3237-45
Japanese
Review
Inohara, N. Stimulation of immunity from bacteria without infection and human related diseases.
感染を伴わない細菌からの免疫刺激と私たちの病気. 山梨大学学会誌
Inohara, N. Tale of Nod2
Nod2発見物語 分子消化器病
Masumoto J, Hasegawa M, Inohara, N (2006) The molecular mechanism of the autoinflammatory disease.
NOD蛋白質の機能から考える.『自己炎症疾患』発症の分子メカニズム
臨 床免疫. 2007 Apr;30(2):68-77.
Inohara, N, Hasegawa M (2006) Host immune responses mediated by Nod proteins.
Nodタンパク質を介した細菌に対する生体防御機構 細胞工学 2006 7, 744-750
Hasegawa M, Inohara, N (2006) Novel therapeutic strategies predicted from studies of IBD susceptibility genes.
IBD 疾患感受性遺伝子からみた治療戦略は可能か 分子消化器病 (2006) 6, 38-48
Hasegawa M, Inohara, N (2006) Nod2
分子細胞治療 2006年1月号
Inohara N. (2004) Bacteria/host interaction mediated by Nod proteins
日 本細菌学雑誌 59, 483-496 (2004)
Tanabe T, Inohara N. (2004) Functional analysis of Nod2 deficiency. Molecular Gasteroenterology.
Nod2分子の機能とその異常をさぐる 分子消化器病 1, 118-127,Masumoto J, Inohara N. (2004) Nod proteins and associated diseases. Inflammation and Immunity
Nodタンパク質とその関連疾患 炎症と免疫 12, 148-186Masumoto J, Inohara N. (2003) Crohn's disease and Nod2.
クローン病とNod2 分子細胞治療 2,616-624
Inohara, N. (2003) Signaling mechanism of programmed cell death.
計画細胞死のシグナル伝達 機構 臨床検査 47: 419-427Inohara, N. (2002) Inflammatory bowel diseases and Nod family members.
炎 症性腸疾患とNodファミリー 39 (9), Molecular MedicineInohara, N. (2002) Nod family proteins and related diseases.
Nod ファミリータンパク質と関連疾患 39 (6), Molecular Medicine 652-659Ogura Y, Inohara, N. (2002) Genes for susceptibility of inflammatory bowel diseases. BIO Clinica 17 (1) 23-27.
BIO Clinica 炎症性腸疾患と遺伝子異常Inohara, N. Molecular Mechanism of Apoptosis, An Overview from Structure Analyses of Apoptosis. Jikken Igaku
実験医学 アポトーシス実行・調節因子の構造からみたアポトーシスの分子機構 (2001) 19(13) 1615-1621Inohara, N. Functions of Bcl-2 family members.
Meneki Immunology Frontier 2001 April; 12(4): 6-22
免疫Immunology Frontier Bcl-2ファミリーの機能Inohara, N., Koseki, T. Pathways and Principles of Caspase Activation. Saibokogaku (Cell technology).
細胞工学 Caspase活性化の機構 NF-kB活性化との類似(1999) 12月号 18, 1781-1785.
Inohara, N. What we can get from technology for regulation of cell life and death. Seibutu-kogaku Kaishi (JFB)
生物工学会誌 細胞の生死を制御する技術で 得られるもの (1998) 76, 511Inohara, N. Regulation of apoptosis by CIDE/DFF family members. Jikken-igaku (Experimental Medicine)
実験医学 CIDE/DFFファミリーによるアポトーシスの制御 10月号カレントトピックス (1998) 16, 1924-1927Inohara, N., Koseki, T. Structures and functions of apoptosis regulators. Saibokogaku(Cell technology)
細胞工学 アポトーシス調節蛋白質の構造と機能(1998) 17, 875-880Inohara, N. Informatics of apoptosis. Saibokogaku(Cell technology)
細胞工学 アポトーシスにおける情報(1998) 17, 866-867Inohara, N. Bcl-2 and harakiri.
Meneki Immunology Frontier 1998 Jan;8(1):34-36
Bcl-2とハラキリ 免疫Immunology FrontierOhta S, Inohara N
Molecular mechanism of regulation of apoptosis and related diseases.
Nippon Ika Daigaku Zasshi (J. Nippon Med. Sch) 1996 Apr;63(2):95-105
アポトーシス調節機構と関連疾病 日本医科大学雑誌Inohara N, Shimomura, S. Seibutu to Kagaku(Life and Science) Structure and functions of the auxin-binding protein: Does the glycoprotein located on membrane medicate transduction of auxin-response?" Kagaku To Seibutsu (Chemistry and Life) 28, 71-73 (1990)
オーキシン結合タンパク質の構造と機能:膜に局在する糖タンパク質. オーキシン情報伝達に関与するか 化学と生物
Other Publications
Patents (US
and non-US, including proposed ones)
"Gene therapy approaches to target cell death for Cancer treatment: compositions and methods"human ARC
mouse Bimp1
mouse Bimp2
mouse CIDE-A
human CIDE-A
mouse CIDE-B
mouse CIPER
human CIPER
human CLARP
human Harakiri
mouse Mtd
mouse Diva
human Nod1
human Nod2 20020127673, 20020197616, 20020127673
human RICK
